Gut-Brain Regeneration
Transcription
Gut-Brain Regeneration
Gut-Brain Regeneration: The microbiome as a new avenue for therapeutic management Zach Bush, MD Internal Medicine, Endocrinology and Metabolism Founder, Director of Clinical Affairs Revolution Health Center Scottsville, VA Founder, CEO Biomic Sciences USA Ranks 49th in health outcomes 1st World Epidemics • • • • • • • • • Autism 1:68 Attention Deficit 1:10 (70% medicated) Asthma 1:10 Allergy 1:4 Diabetes 1:4 Obesity 1:3 Major Depression 1:2 Cancer 1:2 Dementia 1:1 Root Cause of Aging and Disease Root Cause of disease? Inflammation is the root of all chronic disorder and disease Autism Oxidative Stress • Acute inflammation can save our lives – Injury Repair – Infection control • Chronic inflammation – oxidative stress = positive charge/acid – Shutdown/overwhelm of the antioxidant system chronic inflammation = loss of communication What is the RootRoot Cause of Aging and Disease Cause of Inflammation? Ecosystem News • Bacterial population patterns in the human gut predict occurrence of chronic inflammatory disease – – – – – – Obesity/Diabetes Asthma Autoimmunity Cancers Dementia Autism The GALT • Gastrointesinal Associated Lymphatic Tissue GALT: 80% of the antibodies in your body are made here Gut Inflammation Food Sensitivity Asthma/Eczema Allergy Autoimmune Intercellular Tight Junctions Firewalls of Defense Gut/Brain Axis • Gut injury: Gluten, Glyphosate, Lipopolysaccharides • Zonulin goes systemic • Tight junction injury – Gut – Blood/brain barrier – Vascular system – Kidney tubules Gut/Brain Axis • Leaky Brain – Interleukin inflammatory cytokines – Neuro transmitter dysregulation – Neuro-hormonal stress A catastrophic vulnerability Bacteria Unprotected Membranes Tight Junction Toxins Bacteria Bacterial metabolites: Carbon-based Redox system • Each bacterial species (30,000 species) creates a unique subset of carbon metabolites during the digestive process Carbon Redox • These function as an interspecies molecular communication network that allows for coordinated cell protection, injury response, and repair www.restore4life.com What are your bacteria saying? • Dysbiosis: broken ecosystem – Monoculture Antibiotics, pesticides, chemicals, processed foods • Weeds grow up: E.Coli, Klebsiela, Psudomonas, Candida Probiotics – 3 - 24 species, $30 Billion monoculture Monoculture = limited vocabulary = limited defense • Optimal bowel ecology = 20,000 species Biodiversity = fluid communication = strong defenes Leaky Gut/Brain Leak Gut GLYPHOSATE BACTERIAL/YEAST OVERGROWTH GLUTEN Toxic Peptides CXCR3 Enzymes ENZ Chronic Inflammation Inflammation Leaky Gut TJ breakdown ZONULIN Vagal Nerve Stimulation and CNS inflammation Functional Gut Barrier www.restore4life.com Leaky Gut in real time CONTROL Gluten in 1 slice of pizza www.restore4life.com Bacterial Communication Frontlines of Defense TIGHT JUNCTIONS TEER ohms/cm2 Bacterial communication impacts tight junction function www.restore4life.com CONTROL GLUTEN and RESTORE www.restore4life.com RESTORE GLUTEN What’s in Restore? • Carbon-based redox molecules extracted from fossil soil in the South West United States • Trace micronutrients – minerals and amino acids with concentration profiles similar to that of a sweet potato skin • Unprecedented results in cellular safety studies – Gold-standard Renal Tubule Toxicity studies – No LD50, extends life of cell lines at every concentration – Even at 100% concentrations Restore Logistics • 1 tsp to 1 TBL three times daily before or with meals • For very sensitive kids: – 2-5 drops by mouth – plain or with non-chlorinated water/juice – Slowly increase to 1 tsp three times daily • Once on restore you can stop probiotics and digestive enzymes to speed recovery of natural gut biome diversity and healthy digestive processes • No drug-drug interactions References 1. Centers for Disease Control and Prevention (CDC), Key Findings: Trends in the Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for ADHD: United States, 2003-2011 the National Survey of Children's Health (NSCH) 2. Ellwood P, Williams H, Aït-Khaled N, Björkstén B, Robertson C, ISAAC Phase III Study Group. Translation of questions: The International Study of Asthma and Allergies in Childhood (ISAAC) experience. Int J Tuberc Lung Dis. September 2009; 13(9): 1174-1182 3. Massey JT, Moore TF, Parsons VL, Tadros W. Design and estimation for the National Health Interview Survey, 1985–1994. National Center for Health Statistics. Vital Health Stat 1989;2(110) 4. Botman SL, Moore TF, Moriarity CL, Parsons VL. Design and estimation for the National Health Interview Survey, 1995–2004. National Center for Health Statistics. Vital Health Stat 2000;2(130) 5. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014 References 6. Janeway, CA Jr.; et al. (2001). "The mucosal immune system". Immunobiology. New York: Garland Science. 10-13 7. Salminen S, Bouley C, Boutron-Ruault MC, et al. (1998). "Functional food science and gastrointestinal physiology and function". British Journal of Nutrition 80 (S1): S147–S171 8. Moriame G; et al. Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of HIV Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection Journal of Virology, August 2006, p. 8236-8247, Vol. 80, No. 16 9. Abbas A.B.; Lichtman A.H. (2009). "Ch.2 Innate Immunity". In Saunders (Elsevier). Basic Immunology. Functions and disorders of the immune system (3rd ed.) 10. Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). "Inflammation in wound repair: molecular and cellular mechanisms". Journal of Investigative Dermatology 127 (3): 514–525 11. Van Dorpe, S; et al. (2012). "Brainpeps: The blood–brain barrier peptide database". Brain structure & function 217 (3): 687–718 12. Schneider, Stefan W.; et al. (March 2004). "Glioblastoma cells release factors that disrupt blood–brain barrier features". Acta Neuropathologica 107 (3): 272–276 References 13. H Chen; EE Konofagou. Journal of Cerebral Blood Flow & Metabolism (2014) 34, 1197–1204 14. H Matsui ; et al. (2011). The pathophysiology of non-steroidal antiinflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine J Clin Biochem Nutr. 2011 Mar; 48(2): 107–111 15. Eadon MT; et al. Endotoxemia alters tight junction gene and protein expression in the kidney (2012). Am J Physiol Renal Physiol. 2012 Sep 15; 303(6): F821–F830