insearchoflastingsolu tionstohiv / aids
Transcription
insearchoflastingsolu tionstohiv / aids
2 0 0 7 A N N U A L R E P O R T I N S E A R C H S O L U T I O N S T H E F O R F O U N D A T I O N A I D S R E S E A R C H O F T O L A S T I N G H I V / A I D S a m f A R , f o r T h e A ID S R e s e ar c h , d e d i c at e d g l o b a l F o u n d at i o n t o A ID S t h r o u g h i s e n d i n g t h e e p i d e m i c i n n o v at i v e r e s e ar c h . Cover photos (from top): TREAT Asia Community Programs Manager Jennifer I-Ching Ho holds an HIV-positive child (photo: Karl Grobl); Dr. Nolwenn Jouvenet, Aaron Diamond AIDS Research Center (photo: Dr. Rowena Johnston); Shan Grant, Miguel Rivera, and Robert Green (photo: Winnie McCroy). FROM THE CHAIRMAN A Global Force Against a Global Epidemic FROM THE CHIEF EXECUTIVE OFFICER Good Research Drives Good Policy 02 03 PEOPLE LIVING WITH HIV/AIDS 04 MAJOR ACCOMPLISHMENTS 06 RESEARCH 08 GLOBAL INITIATIVES 15 PUBLIC POLICY 22 EDUCATION AND INFORMATION GIVING Individual Giving Institutional Giving In-Kind Contributions Planned Giving Volunteer Support Workplace Giving FINANCIAL SUMMARY From the Treasurer and the Chair of the Finance and Budget Committee Statement of Activities and Changes in Net Assets Statement of Financial Position LEADERSHIP AND ADVISORY COMMITTEES ACKNOWLEDGMENTS 26 30 44 46 f r o m t h e C h a i r m a n A Global Force Against a Global EPIDEMIC Of the 33 million people living with HIV/AIDS, more than 90 percent are in the developing world. For most of its 23 years at the leading edge of the fight against AIDS, amfAR has brought AIDS research, prevention, and education to countries hard hit by the epidemic. A global health threat demands nothing less than a global response. A couple of years ago, we changed our name from the American Foundation for AIDS Research to The Foundation for AIDS Research to reflect the increasingly international scope of both the epidemic and amfAR’s work. The TREAT Asia Network that amfAR formed in 2001 is now a highly regarded model of regional collaboration on HIV/AIDS research, education, and training across Asia and the Pacific. In 2007 we launched an important new international venture: the MSM amfAR Annual Report 2007 02 Initiative. The first round of community awards that form the core of this initiative will support front-line organizations working to combat the rapid and deadly spread of HIV among men who have sex with men (MSM) in Africa, the Caribbean, and Southeast Asia. In 2008, additional awards will be made for innovative programs in Latin America and Asia and the Pacific. Here in the U.S., some of our own cities have rates of infection that rival parts of the developing world. In Washington, D.C., one in 20 residents is HIV positive. So we continue to fight for evidence-based policies that are essential to reducing infection rates and for adequate levels of government funding for HIV/AIDS research, treatment, and From the Chairman prevention. The international growth of amfAR’s programs has been matched by a corresponding expansion in the fundraising arena. For many years, our successful Cinema Against AIDS series has raised funds and brought AIDS awareness to a global audience during the Cannes International Film Festival. In 2007 we were invited to bring the event to the Rome and Dubai film festivals. These new venues enable us to teach new audiences about the vital importance of AIDS research and to combat HIV-related stigma. Our fundraising efforts will be greatly assisted by the passion and dedication of Sharon Stone, who has taken on the role of global fundraising chairman. On the staff side, we are pleased that Kevin Frost, who ably served for many years as vice president for global initiatives, has accepted the position of chief executive officer. Kevin’s experience, energy, and vision will help guide and drive amfAR as we expand our international initiatives while maintaining our fundamental commitment to AIDS research. As we embrace the challenges that confront us, we recognize that our work and accomplishments would not be possible without the continued support of generous individuals and organizations. Your ongoing commitment inspires us and enables us to quicken the pace of our efforts to end this deadly epidemic. Kenneth Cole Chairman of the Board f r o m t h e C h IEF E X E C U TI V E OFFI C ER Good R esearch D rives Good P olicy I like to think that amfAR has the mind of a scientist and the soul of an activist. For 23 years, we have pushed at the frontiers of AIDS research, investing in unexplored areas that have yielded new treatments, improved prevention methods, and vital clues to HIV eradication. And we have pushed for AIDS-related policies rooted in science, compassion, and common sense. Both advocacy and research require patience and persistence, and can take years to bear fruit. Studies that amfAR funded in 1995, for example, pointed the way to the to patients developing resistance to currently available treatments. While past amfAR grants and fellowships continue to influence the discoveries of today, we launched a new initiative in 2007 that will help shore up the future of AIDS research. Young scientists are often those with the most ingenious ideas, but increasingly fierce competition for funds threatens to drive them away from research on AIDS. Our Mathilde Krim Fellowships in Basic Biomedical Research provide a critical source of funds that will help nurture these AIDS research leaders of tomorrow. While substantial resources are quite rightly being invested in the delivery of treatment to those who need it, there is a growing consensus that insufficient attention is being paid to research. That consensus was enshrined in the Sydney Declaration of 2007, which recommends that 10 percent of all HIV/AIDS funding be devoted to research. amfAR was among almost 2,000 signatories of the Declaration, which stressed that the necessary research should extend well beyond the laboratory. Basic science is essential, of course, but above all, research is about people, communities, and human behavior. As the Sydney Declaration states, “good research drives good policy.” We couldn’t agree more, since it is good policy that delivers the benefits of research to people. As scientists and activists, we shall continue to support the best AIDS research and the smartest AIDS policies until we bring this deadly epidemic to an end. Kevin Robert Frost Chief Executive Officer 03 From the Chief Executive Officer drugs. These so-called CCR5 blockers bring an important new option—and new hope— amfAR Annual Report 2007 development and approval in 2007 of the first medication in a brand new class of AIDS PEOPLE LIVING WITH HIV/AIDS, 2007 amfAR Annual Report 2007 North America 1.3 million (480,000–1.9 million) 04 People Living With HIV/AIDS Caribbean 230,000 (210,000–270,000) World at a Glance • 33.2 million people were living with HIV/AIDS in 2007. • 2.1 million of them were under the age of 15. • 2.5 million people were estimated to be infected with HIV in 2007. • 420,000 were under the age of 15. • 6,800 people contract HIV every day—283 every hour. • 2.1 million people died from AIDS in 2007. • 290,000 of them were under the age of 15. Source: Source: UNAIDS UNAIDS/World Health Organization Latin America 1.6 million (1.4–1.9 million) Global Total: 33.2 million Western & Central Europe 760,000 Eastern Europe & Central Asia 1.6 million (1.2–2.1 million) (600,000–1.1 million) East Asia 800,000 (620,000–960,000) (3.3–5.1 million) (270,000–500,000) Sub-Saharan Africa 22.5 million (20.9–24.3 million) Oceania 75,000 (53,000–120,000) The numbers indicated in parentheses define the boundaries within which the actual numbers lie, based on the best available information. 05 People Living With HIV/AIDS North Africa & Middle East 380,000 South & Southeast Asia 4 million amfAR Annual Report 2007 (30.6–36.1 million) M a j o r A C C OM P L I S HMENT S , 2 0 0 7 Securing the Future of AIDS Research Advocacy Efforts Pay Off Funding sources for promising young scientists have become amfAR has been a leading advocate of the increased federal increasingly difficult to secure, yet these same young research- funding for AIDS research that is necessary to continue U.S. ers are often those with the most innovative ideas. To support leadership in cutting-edge discoveries related to the preven- these future leaders of AIDS research and to advance their tion, care, and treatment of HIV/AIDS. The Foundation’s efforts promising studies, in 2007 amfAR launched the Mathilde Krim contributed to a $619.5 million increase in the FY 2007 budget Fellowships in Basic Biomedical Research. Named for amfAR’s of the National Institutes of Health and an additional $330 founding chairman, the amfAR Annual Report 2007 Krim Fellowships moved from concept to funding in 06 million increase in FY 2008. Syringe Exchange Funding Ban Overturned Major Accomplishments less than a year. In Washington, D.C., where one in 20 residents is living with New HIV/AIDS Drug Class Gains Approval local taxpayer dollars to fund syringe exchange programs— In August, the Food and exchange in the District and has been vocal and persistent in Drug Administration its opposition to the ban. In 2007, both the House and Senate approved maraviroc, the finally removed the restrictive legislative language, an advocacy first in a new class of anti- triumph that was a decade in the making. HIV, the federal government long banned the city from using a proven approach to HIV prevention. Since the ban was imposed, amfAR has provided grants to support syringe HIV drugs called CCR5blockers. amfAR played a major role in spurring Stemming the Tide of AIDS Among Men Who Have Sex with Men the early development of maraviroc through initial research Recent studies show surging rates of HIV infection among men by amfAR grantee Dr. Nathaniel Landau, who first described who have sex the vital role of CCR5 in HIV infection and the likelihood that with men (MSM) blocking it would not be detrimental to human health. A study in resource-limited showed that by simply adding maraviroc to existing combina- countries, where tion antiretroviral therapy, patients are twice as likely to attain discrimination undetectable virus levels. and denial of male-male sex Cutting-Edge Grants and Fellowships continue to fuel In 2007, amfAR awarded 18 research grants and fellowships the epidemic. in two cycles totaling more than $2.1 million. One round of In an effort to awards supported a range of projects aimed at increasing bolster prevention and treatment efforts and to combat stigma, understanding and prevention of rectal HIV transmission; the amfAR launched the MSM Initiative. The cornerstone of the second focused on research that would increase understanding Initiative is a community awards program that will funnel of the social and biological factors that influence, or undermine, urgently needed resources to grassroots groups in developing the effective treatment of HIV/AIDS. countries in support of their innovative HIV/AIDS programs that build on and extend the benefits of current research. Saving the Lives of Children in Asia funded investigators were published in leading peer-reviewed Close to 200,000 children are living with HIV/AIDS in Asia journals. These reports and their dissemination among the and it is estimated that only 20 percent of them are receiv- scientific community are essential for researchers to fit together ing the treatment and care they so desperately need. To help the pieces of the intricate AIDS puzzle. Educating Healthcare Providers amfAR’s TREAT Asia amfAR is one of a small group of AIDS organizations accredited Network launched a to provide continuing medical education to physicians and pediatrics initiative in other healthcare providers. In 2007, the Foundation presented 2006. The initiative a continuing medical education series in 10 U.S. cities address- involves 22 pediatric ing the needs of treatment-experienced patients. The series clinics, hospitals, and reached more than 550 health- research centers across care professionals, primarily Asia that are working nurse practitioners and physician collaboratively on HIV assistants with heavy HIV case treatment and clinical loads. Two community forums research. A pediatric on antiretroviral therapy were HIV observational also conducted, along with eight database, established think tanks that examined gaps in 2007, is now pooling patient information that will help in HIV/AIDS education in the U.S. researchers find urgently needed answers to the optimal treat- and ways to fill them. ment of pediatric HIV. Giant Steps for MSM in Asia Charting the Worldwide Course of AIDS HIV infection rates are disproportionately high among MSM in In an effort to create a global database large enough to many parts of Asia. To fight collectively for regional HIV preven- address detailed questions about the worldwide course of HIV/ tion and treatment services for this long-ignored population, a AIDS, U.S. health authorities established an ambitious interna- consortium of more than 80 grassroots HIV organizations has tional collaboration known as the International Epidemiologic come together as the Purple Sky Network. Its activities across Databases to Evaluate AIDS. TREAT Asia was selected to a large swath of Southeast Asia are coordinated by TREAT Asia. manage the Asia/Pacific section of this project, which began its Thanks in part to the efforts of the Purple Sky Network, five out first year of operation in 2006. of the six countries in the Mekong region have adopted specific plans that address the HIV/AIDS needs of MSM. Tracking the Spread of Drug-Resistant HIV HIV drug resistance is perhaps the single greatest factor Expanding the HIV Knowledge Base influencing the long-term success of treatment scale-up efforts amfAR-funded research continues to generate a steady stream in Asia. In 2007, TREAT Asia began enrolling clinical studies of important new knowledge about HIV/AIDS. In 2007, more to monitor the development of HIV drug resistance in Asia. than 40 scientific papers authored or co-authored by amfAR- These studies will help to develop capacity for monitoring and surveillance of the spread of drug-resistant HIV in developing countries. 07 Major Accomplishments life for these children, amfAR Annual Report 2007 improve and extend M RE S EAR C H illions of people with HIV/AIDS are living longer, healthier lives as a direct result of AIDS research. The powerful anti-HIV drugs that are increasingly finding their way to even the most far-flung populations all had their genesis in the laboratory. Three of the AIDS drug classes in use today have their origins in amfAR-funded research. Similarly, AIDS research has helped prevent countless new HIV infections. In many parts of the developed world, for example, mother-to-child transmission of HIV has been all but eliminated. This is in large part due to the use of antiretroviral drugs to block mother-to-child transmission, a concept pioneered by amfAR-supported research in the early days of the epidemic. Today, amfAR continues to support pioneering studies in areas that are not being adequately investigated by others. the timing of their establishment, in order to understand how potential cures must work. Working on the frontiers of AIDS research, amfAR-funded scientists are attacking HIV from numerous angles. amfAR’s New AIDS Drug Has Roots in amfAR Research research strategy can be divided into three objectives: In 2007, the first in a new class of anti-HIV drugs became available to patients who are not responding to other AIDS • Ensuring that all people living with HIV reap the benefits of medications. Approved by the FDA in August, maraviroc acts by blocking HIV’s access to the CCR5 protein on the surface of susceptible cells. A study of more than 600 patients showed that adding maraviroc to combination antiretroviral therapy • Searching for lasting solutions leading to an AIDS-free was twice as likely to result in undetectable virus levels. It was amfAR grantee Dr. Nathaniel Landau and others who, in the future. Spreading the Benefits of AIDS Research: Optimizing Treatment Not everyone has benefited equally from the enormous advances in HIV/AIDS treatment of recent years. Biological factors can influence responses to treatment, while social circumstances can hinder access to HIV testing and medical care. In June 2007, amfAR granted nearly $1.2 million for 10 studies aimed at gaining a better understanding of these impediments to optimal HIV treatment and care. Grantee Dr. Jennifer Sayles of the University of California, Los Angeles, is studying the validity of a new measure of HIV- 1990s, identified the key role of CCR5 in HIV infection and illuminated a path to developing a new drug class. amfAR grantee Dr. Nancy Shulman of Stanford University and Palo Alto V.A. Medical Center has explored whether maraviroc can also decrease the activation of the immune system, which may also help prevent disease. She said of her research, “If maraviroc can decrease HIV disease both by blocking HIV entry into cells as well as decreasing immune activation, this could have implications for broadening the use of maraviroc— even in patients who might otherwise seem to be unsuitable candidates for the drug.” related stigma in women, with the long-term goal of identifying factors that might guide future interventions to improve the quality of women’s healthcare. The number of women living with HIV is increasing, and around the world, women face stigma and even violence because of their HIV status. The U.S. is no exception, according to a survey conducted by Harris Interactive for amfAR in 2007 (see page 29). Reducing stigma would dismantle a pervasive barrier to HIV testing, treatment, and care. Three of the new studies will assess the implications of changes in HIV testing recommendations adopted by the Centers for Disease Control and Prevention (CDC) in 2007. In the face of stubbornly high infection rates in the U.S., the CDC now advises healthcare professionals to perform routine HIV screening of adults, adolescents, and pregnant women. Other researchers will examine the influence of biologi- cal factors on treatment patterns. Dr. Stephen Kent of the University of Melbourne, Australia, is studying HIV reservoirs, where the virus persists beyond the reach of the immune system or antiretroviral therapy. He is examining the nature of the virus strains that become part of these reservoirs, as well as “Twenty-five years after the first identification of AIDS, the taboos that surround an open discussion of sexual behavior are still haunting us in our efforts to contain this pandemic. It is time for us to take an honest and unflinching look at how HIV is spread and how to minimize the risks.” amfAR Annual Report 2007 particularly in the area of HIV prevention; and 09 Research past research accomplishments; • Addressing the current needs of vulnerable populations, The Krim Fellowships are a fitting tribute to the vision and unwavering commitment to research of amfAR Founding Chairman Dr. Mathilde Krim. amfAR Annual Report 2007 10 Research I Rejuvenating the Field of AIDS Research “The Krim Fellowships are an excellent example of how amfAR facilitates the entry of young scientists into the field of AIDS research. They’ll be the leaders of tomorrow.” n January 2007, amfAR launched a new research initiative in honor of its founding chairman: The Mathilde Krim Fellowships in Basic Biomedical Research. The aim was to confront an urgent problem. At a time when HIV/AIDS kills more than 2 million people each year, it has become increasingly difficult for bright young scientists to secure funding for their innovative research projects. The proportion of funding awarded to scientists aged 35 or younger has declined steadily from 23 percent in 1980 to below four percent in 2001, according to a study by the National Institutes of Health. Meanwhile, the share of grants going to older scientists has increased sharply. The result is that young scientists, looking for support for original ideas, are increasingly forced to leave academia. Addressing this gap and moving from concept to funding in less than a year, the Krim Fellowships are designed to support bright young scientists’ biomedical research aimed at treating, preventing, and eradicating HIV/AIDS. The program funds two years of postdoctoral research, with the possibility of one additional year of research support during the first year in a tenure-track position. The first round of applications for the Krim Fellowships was reviewed in the fall of 2007. “We received many applications of extraordinarily high caliber from leading laboratories around the world,” said Dr. Rowena Johnston, amfAR’s vice president of research. “The overwhelming response to this program underscores the pressing funding needs of new researchers as support has dried up from other sources.” “The Krim Fellowships are an excellent example of how amfAR facilitates the entry of young scientists into the field of AIDS research,” said Dr. Paul Bieniasz of the Aaron Diamond AIDS Research Center in New York. “They’ll be the leaders of tomorrow.” Understanding Rectal HIV Transmission “Twenty-five years after the first identification of AIDS, the taboos that surround an open discussion of sexual behavior are still haunting us in our efforts to contain this pandemic,” said Dr. Rowena Johnston, amfAR’s vice president for research. “It is time for us to take an honest and unflinching look at how HIV is spread and how to minimize the risks.” Up until now, there have been few studies of the extent to which HIV is spread by anal intercourse—a gap in knowledge that has left both men and women vulnerable to infection. Increased understanding of rectal transmission will play an important role in developing strategies to reach people who have previously been overlooked in HIV prevention. In January 2007, amfAR awarded eight grants and fellowships totaling nearly $1 million for research that tackles both the biological and social aspects of rectal transmission in order to remove the barriers to understanding and preventing this widespread mode of transmission. Toward a Cure The development of highly active antiretroviral therapy (HAART), which has extended and improved the lives of many people living with HIV, has been “elite controllers” may provide insight into slowing or even hailed as one of the great scientific achievements of the last stopping viral reproduction. Expanding the HIV Knowledge Base the burden of taking medications—which can cause debilitat- An important indicator of the caliber and productivity of ing side effects—for the rest of their lives. amfAR-supported researchers is the quantity of studies published in peer-reviewed journals. In fiscal year 2007, more amfAR-funded scientists are rising to the challenge. A number of researchers who received grants under amfAR’s viral than 40 papers by amfAR grantees and fellows appeared in eradication initiative continued their important work in 2007, the scientific press, contributing a wealth of important new exploring potential methods of flushing out latent virus that is knowledge about HIV that can be exploited by the broader hidden beyond the reach of current antiretroviral therapy. research community. • amfAR fellow Dr. Fedde Groot is studying the ways in which Defining Drug Targets HIV targets uninfected cells in the gastrointestinal (GI) tract Dr. Jacqueline Reeves of Monogram Biosciences and Dr. Oliver and how virus spread can be controlled by drugs or antibodies. Hartley of the University of Geneva studied the process of Since the degree of cell loss in the gastrointestinal tract may mutation by which HIV is able to evade containment by current largely determine the course of the disease, Dr. Groot’s findings drug therapies. There are two varieties of co-receptor that HIV may guide future efforts to reduce or prevent cell loss. uses to bind to a cell: CCR5 and CXCR4. CCR5 is the portal • In a similar vein, Dr. Martin Markowitz and his team at the that HIV uses in nearly all cases of initial HIV infection. But Aaron Diamond AIDS Research Center are exploring potential over time, particularly in the absence of anti-HIV treatment, the viral reservoirs in the GI tract, and have found that T-cell levels virus often evolves into a form that can use CXCR4. And this in the intestinal tract remained below normal despite treat- mutated version usually signals a much more virulent disease. ment. These study results will help guide interventions aimed at Drs. Reeves, Hartley, and colleagues identified the intermediate preventing the loss of, or replenishing, immune cells in the GI steps the virus progresses through in the switch from using tract, which are killed early in infection. CCR5 to CXCR4. Their research, published in the Journal of • Dr. Steven Deeks of the University of California, San Fran- Virology, will help determine both the potential and the limita- cisco, is examining HIV-positive people whose immune systems tions of anti-HIV drugs that target the CCR5 co-receptor. have controlled the virus without treatment. Studying these Another amfAR grantee, Dr. Pantelis Poumbourios of the Working with a group of amfAR-funded researchers in Australia, Dr. Ya-Lin Chiu identified a new group of immune cells that harbor HIV. 11 Research virus from the body completely, and to free HIV patients from amfAR Annual Report 2007 25 years. But the ultimate goal is to find ways to eradicate the Burnet Institute in Victoria, Australia, described in the Journal of capitalize on recent research findings and emerging areas of Biological Chemistry his exploration of HIV-cell fusion, a process study. In addition to one-year grants for senior researchers, targeted by one of the newest anti-HIV drugs, Fuzeon the Foundation funds two-year fellowships for postdoctoral (enfuvirtide). The new knowledge gained by Dr. Poumbourios scientists working with an established mentor. The Founda- and his research group may facilitate the discovery of new tion’s support of early-stage and sometimes high-risk projects drugs to block the fusion process, and thus the formation of is a proven investment: for every dollar scientists receive from infectious virus. amfAR, they receive an average of $12 in subsequent funding from other sources. Identifying Roadblocks to a Cure Melbourne, Australia, worked with amfAR fellows Dr. Ya-Lin A Relentless Pursuit of Prevention, Treatment, and Cure Chiu and Dr. Secondo Sonza to identify a new group of immune In the months and years ahead, amfAR will continue to make cells that harbor HIV. They found that, in addition to CD4+ judicious investments in the research that is essential for the amfAR Annual Report 2007 cells, a small subset of immune cells known as monocytes also ultimate conquest of AIDS. Preventing all new HIV infections harbor HIV during HAART. The group found that these cells calls for contributions from every area of HIV/AIDS research. may represent a continuing source of viral persistence, even Progress towards designing an AIDS vaccine or microbicide, in individuals with viral loads suppressed below detectable for example, is being made by biomedical researchers, while limits for prolonged periods of time, and could therefore limit social and behavioral scientists seek to understand the social the potential for a cure. Their findings, which appeared in the and psychological factors that can affect the adoption of HIV Journal of Immunology, support the necessity of pursuing all prevention and risk reduction behaviors. Unlike other funders 12 possible concepts for curing HIV/AIDS, for people at all stages of HIV/AIDS research, amfAR aims to integrate these facets of of the disease. research in the drive to ensure not only that new prevention amfAR grantee Dr. Suzanne Crowe of the Burnet Institute in Research and treatment interventions are discovered but also that they Minor HIV Genes are successfully put into practice. The amfAR-funded lab of Dr. Nathaniel Landau and amfAR- supported fellow Dr. Lei Fang researched two accessory or the inexorable spread of drug-resistant strains of HIV demand “minor” genes of HIV, Vif and Vpr. Writing in Virology and the continual pursuit of new treatments. amfAR-funded Proceedings of the National Academy of Sciences, the research team scientists will continue to search for new angles from which described their work, which could point the way to new targets to attack the virus. Our brightest hope for the future, however, for anti-HIV drug development. lies in understanding the mechanisms by which HIV evades not The often debilitating side effects of current AIDS drugs and only the vigorous immune response mounted by those who HIV and the Brain amfAR-funded scientist Dr. Beau Ances studied the changes in mental function associated with HIV infection and the impact of HAART on cognitive function. Despite a decline in the incidence of HIV-related dementia due to increased use of HAART, it appears that some patients still experience cognitive problems. Writing in Archives of Neurology, Dr. Ances and his team described the new, more sensitive test they created to measure HIV’s effects on the brain. Securing the Future of AIDS Research With the help of its Scientific Advisory Committee and other independent HIV/AIDS experts who volunteer to take part in the peer-review selection process, amfAR moves quickly to are infected, but also the very potent drugs that constitute the current arsenal of anti-HIV therapy. A clearer understanding of these mechanisms will help create the roadmap to a cure. October 1, 2006, to September 30, 2007. Grants funded during fiscal year 2007 but awarded in previous years are shown with the year of the award in parentheses. Research Grants Preventing HIV Transmission Development of a standard rectal microbicide delivery device Alex Carballo-Diéguez, Ph.D. Research Foundation for Mental Hygiene, Inc. New York, NY $119,992 Colorectal explants to study HIV transmission and microbicides Charlene Dezzutti, Ph.D. Magee-Womens Research Institute and Foundation Pittsburgh, PA $120,000 HIV-1 infection of mucosal lymphocytes and tissue explants Benjamin K. Chen, M.D., Ph.D. Mount Sinai School of Medicine New York, NY $90,000 (2006) Interaction of HIV with the macaque female genital tract Thomas J. Hope, Ph.D. Northwestern University Chicago, IL $90,000 (2006) Viral transmission and replicative fitness Dale McPhee, Ph.D. St Vincent’s Institute Fitzroy, Australia $90,000 (2006) Epithelial injury and HIV penetration after simulated ejaculation Craig Hendrix, M.D. Johns Hopkins University School of Medicine Baltimore, MD $120,000 Female genital ulcer as a portal of HIV entry Eva Rakasz, Ph.D. University of Wisconsin–Madison Madison, WI $90,000 (2006) Mediation effect of network function on HIV risk behavior among Chinese Hongjie Liu, Ph.D. School of Medicine, Virginia Commonwealth University Richmond, VA $119,988 Understanding the properties of transmitted HIV-1 variants Manish Sagar, M.D. Brigham and Women’s Hospital/ Harvard Medical School Boston, MA $90,000 (2006) Anal sex practices in high-risk South African women and men Joanne Mantell, Ph.D. Research Foundation for Mental Hygiene, Inc. New York, NY $119,946 Amphibian derived microbicides that inhibit HIV infection Derya Unutmaz, M.D. Vanderbilt University Medical School Nashville, TN $90,000 (2005) Rectal transmission of HIV-1 in a novel mouse model Roberto Speck, M.D. Division of Infectious Diseases, Department of Internal Medicine, University Hospital of Zurich Zurich, Switzerland $119,822 Optimizing HIV Treatment Recent changes in HIV testing recommendations: impact on youth at risk Marya Gwadz, Ph.D. NDRI USA, Inc. New York, NY $119,598 Vif:APOBEC3G: assay and structure Nathaniel Landau, Ph.D. Salk Institute for Biological Studies La Jolla, CA $90,000 (2004) Antibody mimetic inhibitors of HIV fusion Richard Roberts, Ph.D. California Institute of Technology Pasadena, CA $86,302 (2004) Establishment of the HIV reservoir during acute infection Stephen Kent, M.D. University of Melbourne Melbourne, Australia $120,000 Pursuing HIV Eradication How to test: policy and practice after the CDC recommendations Lori Leonard, Sc.D. Johns Hopkins School of Public Health Baltimore, MD $120,000 Genetic screens for inhibitors of HIV latency Paul Bieniasz, Ph.D. Aaron Diamond AIDS Research Center New York, NY $120,000 (2006) CDC HIV testing guidelines: unresolved ethical concerns Roland Merchant, M.D., Sc.D. Rhode Island Hospital Providence, RI $120,000 HIV controllers: a potential model for HIV eradication Steven Deeks, M.D. University of California, San Francisco San Francisco, CA $120,000 (2006) AHI awareness and entry into care among high risk populations Robert Remien, Ph.D. Research Foundation for Mental Hygiene, Inc. New York, NY $119,654 The role of CCR7 ligands and dendritic cells in latent HIV infection Sharon Lewin, F.R.A.C.P., Ph.D. Monash University Melbourne, Australia $120,000 (2006) The impact of stigma on access to HIV treatment and care Jennifer Sayles, M.D. University of California, Los Angeles, David Geffen School of Medicine Los Angeles, CA $120,000 Immunologic benefits of CCR5 inhibitor intensification Nancy Shulman, M.D. Palo Alto Veterans Administration Medical Center and Stanford University Palo Alto, California $107,644 Evolutionary screen to identify novel TRIM restriction factors Harmit Malik, Ph.D. Fred Hutchinson Cancer Research Center Seattle, WA $90,000 (2005) Reservoirs of SIV in long-term nonprogressors in rhesus macaques Binhua Ling, M.D., Ph.D. Tulane National Primate Research Center Covington, LA $120,000 (2006) The GI tract may be a reservoir of ongoing viral replication during HAART Martin Markowitz, M.D. Aaron Diamond AIDS Research Center New York, NY $120,000 (2006) Role of lymph node dendritic cells in HIV infection David McDonald, Ph.D. Case Western Reserve University Cleveland, OH $120,000 (2006) Identifying the major tissue reservoirs in SIV/SHIV infected macaques Bapi Pahar, Ph.D. Tulane National Primate Research Center Covington, LA $120,000 (2006) amfAR Annual Report 2007 All projects listed below were supported by amfAR during the period Impact of PD-1 on the establishment and maintenance of the HIV-1 reservoir Elias Haddad, Ph.D. Université de Montréal, Centre de Recherche du CHUM Montréal, Canada $107,568 13 Research 2007 RESEARCH GRANTS AND AWARDS Effects of valproic acid therapy on gut mucosal HIV reservoirs Jean-Pierre Routy, M.D. McGill University Health Centre Montréal, Canada $119,827 (2006) Viral persistance in the MGT of RTSHIV infected macaques on HAART Miranda Xhilaga, Ph.D. Mentor: Sharon Lewin, F.R.A.C.P., Ph.D. Monash University Melbourne, Australia $125,000 Research Fellowships Molecular mechanisms of the HIV-1 coreceptor CCR5 function Gabriel Birrane, Ph.D. Mentor: John Ladias, M.D. Beth Israel Deaconess Medical Center Boston, MA $99,000 (2006) Preventing HIV Transmission amfAR Annual Report 2007 14 Colorectal responses to HIV-1 and modulation by microbicides Carolina Herrera, Ph.D. Mentor: Robin Shattock, Ph.D. St George’s University of London London, United Kingdom $125,000 Anal intercourse, STIs and HIV among STD clinic clients Marjan Javanbakht, Ph.D. Mentor: Peter Anton, M.D. University of California, Los Angeles Los Angeles, CA $112,193 Research HIV mucosal transmission in humanized mice model Liguo Zhang, Ph.D. Mentor: Lishan Su, Ph.D. University of North Carolina at Chapel Hill Chapel Hill, NC $99,000 (2006) Harnessing RNA interference as an HIV microbicide Deborah Palliser, Ph.D. Mentor: Judy Lieberman, M.D., Ph.D. CBR Institute for Biomedical Research Boston, MA $99,000 (2005) Structure based design of gp41 analogs for HIV1 vaccines Florence Brunel, Ph.D. Mentor: Philip Dawson, Ph.D. Scripps Research Institute La Jolla, CA $99,000 (2004) Optimizing HIV Treatment Impulsivity, drug abuse, and HIV medication adherence: An fMRI study Christina Meade, Ph.D. Mentor: Steven Safren, Ph.D. Harvard Medical School–McLean Hospital/Massachusetts General Hospital Belmont, MA $124,000 Designing inducible Pol II systems for RNA interference of HIV-1 Hoshang Unwalla, Ph.D. Mentor: John Rossi, Ph.D. Beckman Research Institute of the City of Hope Duarte, CA $99,000 (2006) The APOBEC3G-Vif interaction as a new HIV therapeutic target Hendrik Huthoff, Ph.D. Mentor: Michael Malim, D.Phil. King’s College London London, United Kingdom $99,000 (2005) Mechanistic study of retroviral entry and restriction in vitro Virginie Sandrin, Ph.D. Mentor: Wesley Sundquist, Ph.D. University of Utah Salt Lake City, UT $99,000 (2005) Mechanism of postentry restriction of HIV-1 by TRIM5alpha Chisu Song, Ph.D. Mentor: Christopher Aiken, Ph.D. Vanderbilt University School of Medicine Nashville, TN $99,000 (2005) Negative regulation of HIV-1 cellular co-factor P-TEFb Matjaz Barboric, Ph.D. Mentor: Matija Peterlin, M.D. University of California, San Francisco San Francisco, CA $99,000 (2004) HIV-1 envelope-gag interactions and assembly in lipid rafts Jayanta Bhattacharya, Ph.D. Mentor: Ramesh Paranjape, Ph.D. National AIDS Research Institute Pune, India $9,000 (2004) Relative fitness of early and late variants of SIV in vitro Yegor Voronin, Ph.D. Mentor: Michael Emermann, Ph.D. Fred Hutchinson Cancer Research Center Seattle, WA $99,000 (2004) Pursuing HIV Eradication Quantitative fMRI of CNS-T ART on HIV brain reservoirs Beau Ances, M.D., Ph.D. Mentor: Ronald Ellis, M.D., Ph.D. University of California San Diego San Diego, CA $125,000 (2006) HIV-1 cell-cell spread in viral dissemination and persistence Fedde Groot, M.Sc. Mentor: Quentin Sattentau, Ph.D. The Sir William Dunn School of Pathology, University of Oxford Oxford, United Kingdom $124,882 (2006) Virologic correlates of subtype-A HIV transmission Richard Haaland, Ph.D. Mentor: Eric Hunter, Ph.D. Emory University Atlanta, GA $99,000 (2006) Role of Tat methylation in HIV latency Sara Pagans, Ph.D. Mentor: Melanie Ott, M.D. The J. David Gladstone Institutes San Francisco, CA $125,000 (2006) Macrophage matrix metalloproteinases role in persistence of HIV-1 in CNS Nicole Webster, Ph.D. Mentor: Suzanne Crowe, M.D. Macfarlane Burnet Institute for Medical Research and Public Health Melbourne, Australia $125,000 (2006) HIV reservoir in central memory T cells Nicolas Chomont, Ph.D. Mentor: Rafick-Pierre Sekaly, Ph.D. Université de Montréal Centre de Recherches du CHUM Montréal, Canada $83,100 (2005) Identification of novel host factors for HIV replication Lei Fang, M.D., Ph.D. Mentor: Nathaniel Landau, Ph.D. The Salk Institute for Biological Studies La Jolla, CA $99,000 (2005) Characterization of HIV env variants that persist during HAART Patrick Harrington, Ph.D. Mentor: Ronald Swanstrom, Ph.D. University of North Carolina at Chapel Hill Chapel Hill, NC $99,000 (2005) Kinetics of HIV reactivation in latently infected T cells Young Kyeung Kim, Ph.D. Mentor: Jonathan Karn, Ph.D. Case Western Reserve University Cleveland, OH $99,000 (2005) Human cellular factors that restrict HIV infection Susana Valente, Ph.D. Mentor: Stephen Goff, Ph.D. Columbia University in the City of New York New York, NY $99,000 (2005) Research Awards New York HIV research centers consortium meeting Sherry Deren, Ph.D. National Development and Research Institutions, Inc New York, NY $5,000 2008 Rectal Microbicide Satellite Meeting Ian McGowan, M.D., Ph.D. Magee-Womens Research Institute and Foundation Pittsburgh, PA $25,000 T G L O B A L INITIATI V E S he widespread availability of antiretroviral drugs has transformed HIV/AIDS for many into a manageable condition—at least in the developed world. But in resource-limited regions, economic constraints, limited healthcare infrastructure, stigma, discrimination, and gender inequality combine to fuel the spread of the epidemic and prevent people with HIV/AIDS from getting the help they need. More than 90 percent of the 33.2 million people with HIV/AIDS live in developing countries, and most do not know they are infected. Over the past two decades, amfAR has steadily expanded its international reach through carefully targeted research, prevention, education, and training initiatives in resourcelimited countries. The MSM Initiative works in partnership with activists such as Dr. Steave Nemande (left), president of AlternativesamfAR Annual Report 2007 16 Cameroun, an organization working on MSM and HIV/AIDS issues in Douala, Cameroon, and Dr. Paul Semugoma (right), a physician in Kampala, Uganda. Global Initiatives The MSM Initiative • To advocate for effective policies and increased funding for Around the world, men who have sex with men (MSM) suffer HIV programs for MSM. that fewer than one in 20 MSM has access to HIV prevention, The cornerstone of the MSM Initiative is a community treatment, care, and services. “MSM have been largely ignored awards program through which amfAR supports the efforts by both social and public health structures in many countries of grassroots groups in developing countries to provide HIV for too long,” stated a recently published study in the journal prevention, treatment, care, and support services to MSM. PLoS Medicine. Looking at HIV prevalence rates in 38 low- and Targeting MSM organizations and networks in Africa, the middle-income countries, the study found that on average Caribbean, and Southeast Asia, an initial request for proposals MSM had a 19.3 times greater chance of being infected than elicited more than 120 applications—85 from Africa alone— the general population. and underscored the enormity of the unmet need. A second disproportionately high rates of HIV infection. It is estimated Laws against male-male sex exist in 85 countries around request for proposals will target groups working in Central and the world. Even in countries without legal prohibitions against South America and in Asia and the Pacific, and awards will be same-sex behavior, pervasive stigma often prevents MSM announced in 2008. from accessing HIV/AIDS prevention services or care. Without appropriate health messages and support, many MSM in these activities, which aim to increase levels of support from govern- countries unknowingly engage in behavior that increases ments and nongovernmental institutions for prevention, treat- their risk of HIV infection. It is small wonder, then, that HIV ment, and support services for MSM. They will also advance prevalence among MSM is as high as 40 percent in Kenya, 27 domestic and international policy efforts to end the stigma, percent in Ukraine, and 21 percent in Uruguay. discrimination, and violence that threaten the lives of MSM and fuel the spread of HIV/AIDS. It is against this backdrop that amfAR launched the MSM Initiative in 2007. The Initiative has three primary goals: The community awards are complemented by advocacy amfAR’s partners in the MSM Initiative are the United Na- tions Joint Programme on HIV/AIDS (UNAIDS) and the Global • To support and empower grassroots MSM organizations; Forum on MSM and HIV. The Initiative is supported by generous • To build understanding and awareness of HIV epidemics grants from the Elizabeth Taylor AIDS Foundation, the Elton among MSM; and • TREAT Asia In the Asia-Pacific region, approximately 4.8 million people are living with HIV and 432,000 became newly infected in 2007. In anticipation of escalating rates of infection and a potentially devastating epidemic, in 2001 amfAR launched Therapeutics Research, Education, and AIDS Training in Asia—TREAT Asia. This network of F Fighting Pediatric AIDS: It Takes a Village or almost 200,000 children living with HIV/AIDS in Asia, survival depends on much more than medication. Family and community support are as important as sophisticated medical care, and without access to education, nutrition, transportation, and other necessities, the prognosis for HIV-positive children remains dire. Dr. Pagakrong Lumbiganon has been treating HIV-positive children at Thailand’s Srinagarind Hospital, a TREAT Asia site, for more than a decade and every day she sees the limits of what doctors can achieve. “As physicians,” she says, “we can only provide maybe 20 percent of what children hospitals, clinics, and research institutions now need. With children, HIV infection is not treated just by pills. Children need the care includes 20 adult and 22 pediatric sites in 14 of family, they have to have friends, they have to go to school. It’s not just medical countries. TREAT Asia works with civil society to care.” ensure the safe and effective delivery of HIV treat- The importance of a network of care is an article of faith among HIV/AIDS ment across the Asia-Pacific region, to provide pediatricians. As TREAT Asia steering committee member Dr. Annette Sohn stated at treatment and prevention education to healthcare the network’s September 2007 meeting, “The quality of the collaborative relation- providers and the HIV/AIDS community, and to ship between the caretaker and the child will determine the success of treatment.” conduct clinical research specific to patient populations in the region. Across Asia, government funding for HIV/AIDS pediatric treatment rarely covers support services of any kind. But some TREAT Asia-affiliated pediatric programs have been able to contrive a variety of innovative strategies to help them offer a Improving Treatment and Care for Children Close to 200,000 children are living with HIV/ broader range of services. Dr. Pagakrong’s pediatric HIV/AIDS team at Srinagarind Hospital has looked out- AIDS in Asia and it is estimated that only 20 side its own walls for help, gradually establishing relationships with multiple NGOs, percent of them are receiving the treatment and each of which supports a different aspect of social and family services. care they so desperately need. Since most clinical research has focused on the treatment of adults, But in spite of her successes, Dr. Pagakrong worries about what will happen to her young patients as they come into adulthood. Shaking her head firmly, she says, “We have to do more.” “The pediatrics network is unique in that it is made up of clinicians who are on the front lines of pediatric HIV treatment and clinical research in Asia.” The pediatric HIV/AIDS team at Srinagarind Hospital in Thailand has been able to contrive innovative strategies to help them offer a broader range of services for HIV-positive children. amfAR Annual Report 2007 Action programme, and the M A C AIDS Fund. • 17 Global Initiatives John AIDS Foundation, GlaxoSmithKline’s Positive little is known about the proper treatment of children with HIV. generated a range of useful information for researchers and Pediatricians must grapple with complex questions, such as physicians across Asia. In 2007 alone, seven reports on treat- when to initiate treatment, which drugs to use and at which ment patterns and co-infections were published in prestigious dosages, and when to switch regimens to avoid side effects peer-reviewed journals including The Journal of Acquired Immune or treatment failure. Children face their own psychosocial Deficiency Syndrome, HIV Medicine, and Clinical Infectious Diseases. issues, and require care that extends well beyond antiretroviral An important component of the pediatrics initiative is a therapy. pediatric HIV observational database that was established in To help improve treatment, care, and quality of life for 2007 and is now pooling vital information on the epidemiol- children living with HIV/AIDS across Asia, a pediatrics initiative ogy of pediatric HIV in Asia, disease patterns, and treatment was launched alongside the TREAT Asia network in 2006. The outcomes. The information gathered and analyzed will help initiative’s goals are to: researchers find urgently needed answers to the optimal treatment of pediatric HIV. amfAR Annual Report 2007 18 • Conduct research that is specific and responsive to the TREAT Asia also manages the Asia-Pacific section of the International Epidemiologic Databases to Evaluate AIDS needs of HIV-positive children in the region; • Educate and train healthcare professionals in pediatric (IeDEA), a collaboration established by the U.S. National Insti- tute of Allergy and Infectious Diseases that began its first year treatment and care; • Undertake communications and policy activities that ad- of operation in 2006. The aim of this ambitious initiative is to create a global database large enough for detailed study of dress issues surrounding pediatric treatment and care; and • Strengthen civil society’s understanding of pediatric HIV/ the spread of HIV infection worldwide and to identify trends in AIDS and its capacity for the safe and effective treatment of the use and efficacy of treatments in different regions. TREAT children with the virus. Asia is contributing anonymous data to IeDEA from more than 6,000 patients at 44 clinical centers in the Asia-Pacific region, Global Initiatives The pediatrics initiative coordinates the efforts and pools including Australia. the resources of healthcare professionals and researchers at Drug resistance represents a significant long-term threat to 22 sites in Australia, Cambodia, China, India, Indonesia, Laos, the efficacy of antiretroviral therapy. The TREAT Asia Studies Malaysia, Thailand, and Vietnam. The network represents a to Evaluate Resistance (TASER) are a collaborative effort by combined caseload of more than 4,300 children with HIV. TREAT Asia and the PharmAccess Foundation of the Nether- lands to monitor the emergence and transmission of HIV drug “The pediatrics network is unique in that it is made up of clinicians who are on the front lines of pediatric HIV treat- resistance in Asia and Africa. ment and clinical research in Asia,” said Dr. Annette Sohn, a representative of the pediatrics initiative on the TREAT Asia Help for MSM Steering Committee. “Some of us have had years of experi- TREAT Asia lies at the center of efforts to stem the rising tide ence with antiretroviral treatment, while others lack access to of HIV among men who have sex with men in Southeast Asia. these drugs, but all of us are committed to providing care and In 2006 it was selected as regional coordination secretariat for treatment to children with HIV. By coming together, we have Purple Sky, a network of more than 80 organizations working an opportunity to develop our regional capacity to conduct to improve prevention, treatment, and care for MSM in the multinational research and share clinical expertise.” Greater Mekong Sub-Region, which encompasses Cambodia, China’s Yunnan and Guangxi provinces, Laos, Myanmar, Tracking the Epidemic Thailand, and Vietnam. Collecting accurate data on patterns of HIV disease, demo- Purple Sky was organized in 2006, and by the fall of graphics, modes of transmission, and treatment outcomes is 2007 its advocacy efforts had already made a difference. The essential to developing and implementing effective treatment network was instrumental in convincing the governments of and prevention strategies for the region. The TREAT Asia HIV Cambodia, China, and Laos to add MSM-specific interventions Observational Database (TAHOD), the region’s first such to their national strategic plans on HIV/AIDS. database for HIV/AIDS, houses anonymous data from more “This is a huge change,” said Clif Cortez, a member of the than 3,800 patients at 17 sites. The database has already Purple Sky Network’s advisory board and USAID’s Bangkok regional senior advisor. “Prior to the work of the Purple Sky Inspiring Young Activists Network, none of the national governments in this region were The Asian Community for AIDS Treatment and Advocacy anywhere near being at the table as partners on MSM and (ACATA) is a TREAT Asia mentoring program initiated in HIV.” 2005 with support from GlaxoSmithKline’s Positive Action programme. ACATA has brought young treatment advocates Education and Training together from around the region to increase their knowledge Providing education and training for physicians and other of HIV/AIDS, build their advocacy skills, share experiences, and healthcare professionals is essential to improving HIV treat- connect them to the medical and scientific communities. Most ment and care. Since its inception, TREAT Asia has sponsored ACATA members have reached the end of their three-year and conducted workshops and training sessions in many training cycle and are considering future projects they may countries in the region. undertake together. In Cambodia, TREAT Asia supports several components of the National HIV Care Training program. It provides training Responding to an Epidemic Without Borders for new opportunistic infection/antiretroviral therapy teams at As the world grows smaller through increased travel and district hospitals, support and mentoring visits to new and migration, preventing the spread of infectious diseases such existing teams, regional workshops for the teams, and an as HIV/AIDS becomes ever more urgent. A successful global annual national symposium on care and treatment. response to the pandemic must respond to the needs of people During 2007, TREAT Asia also supported a range of com- at the local level, strengthen national treatment and preven- munity education and training programs, notably in Cambodia, tion efforts, and foster regional cooperation. Such a response China, Thailand, and Vietnam. In addition to establishing Red involves listening to many voices, including national govern- Ribbon Centers through local partnerships in China, which ments, the medical and scientific communities, grassroots provide highly effective treatment support and education for organizations, and individuals in marginalized groups such people affected by HIV/AIDS, TREAT Asia implemented a treat- as sex workers, injection drug users, and MSM. Through its ment literacy training program for women in Cambodia, helped international initiatives and collaborations, amfAR will continue create treatment literature with the Thai AIDS Treatment Action to invest in carefully targeted programs with the greatest Group, and initiated training for peer treatment educators in potential for extending and improving lives among the world’s 10 Vietnamese provinces. It also co-facilitated workshops on most vulnerable populations. antiretroviral treatment for Cambodian women. amfAR Annual Report 2007 holds an HIV-positive child during a site visit in China. 19 Global Initiatives Jennifer I-Ching Ho, manager of TREAT Asia’s community programs, 2007 GLOBAL INITIATIVES GRANTS AND AWARDS All projects listed below were supported by amfAR during the period October 1, 2006, to September 30, 2007. Grants funded during fiscal year 2007 but awarded in previous years are shown with the year of the award in parentheses. Asia Pacific HIV Observational Database amfAR Annual Report 2007 20 Matthew G. Law, Ph.D. National Centre in HIV Epidemiology and Clinical Research University of New South Wales Sydney, Australia $157,465 (2006–Year 1 Subaward) $19,904 (2006–Bridge Funding Grant) $239,069 (Year 2 Subaward) TREAT Asia HIV Observational Database Global Initiatives Vonthanak Saphonn, M.D., Ph.D. National Center for HIV/AIDS, Dermatology & STDs / Cambodia National Institute of Public Health Phnom Penh, Cambodia $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Yi-Ming Chen, M.D., Sc.D. National Yang-Ming University Taipei, China $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Fujie Zhang, M.D. Beijing Ditan Hospital Beijing, China $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Patrick Li, M.B.B.S. Queen Elizabeth Hospital Hong Kong, China $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Nagalingeswaran Kumarasamy, M.D., M.B.B.S., Ph.D. YRG Centre for AIDS Research and Education,VHS Chennai, India $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Sanjay Pujari, M.D. Institute of Infectious Diseases Pune, India $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Tuti Parwati Merati, M.D. Udayana University School of Medicine Denpasar, Indonesia $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Shinichi Oka, M.D. International Medical Center of Japan Shinjuku-ku, Japan $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Adeeba Kamarulzaman, M.B.B.S., F.R.A.C.P. University of Malaya Kuala Lumpur, Malaysia $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Thira Sirisanthana, M.D. Chiang Mai University Chiang Mai, Thailand $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Somnuek Sungkanuparph, M.D. Ramathibodi Hospital Mahidol University Bangkok, Thailand $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Jun Yong Choi, M.D., Ph.D. Yonsei University College of Medicine Seoul, South Korea $15,000 (Year 2 Subaward) TREAT Asia Pediatric HIV Observational Database Matthew G. Law, Ph.D. National Centre in HIV Epidemiology and Clinical Research University of New South Wales Sydney, Australia $172,800 Australia HIV Observational Database Debra Allen, M.B.Ch.B., Dip Med Northern Sydney Central Coast Area Health Services, Holden Street Clinic Gosford, Australia $2,925 (Year 1 Subaward) $1,725 (Year 2 Subaward) Dr. Jonathan Anderson Carlton Clinic Carlton, Australia $7,500 (Year 1 Program Technical Support Agreement) $7,500 (Year 2 Program Technical Support Agreement) David Baker, B.H.B. 407 Doctors Pty., Ltd. Sydney, Australia $7,500 (Year 1 Program Technical Support Agreement) $7,500 (Year 2 Program Technical Support Agreement) Mark Bloch, M.D. Holdsworth House Medical Practice Sydney, Australia $7,500 (Year 1 Program Technical Support Agreement) $7,500 (Year 2 Program Technical Support Agreement) Christopher Lee, M.B.B.S., M.R.C.P. Sungai Buloh Hospital Sungai Buloh, Malaysia $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Nagalingeswaran Kumarasamy, M.D., M.B.B.S., Ph.D. YRG Center for AIDS Research and Education, VHS Chennai, India $15,000 Goa Tau, Master Medicine Port Moresby General Hospital Port Moresby, Papua New Guinea $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Pagakrong Lumbiganon, M.D. Khon Kaen University Khon Kaen, Thailand $15,000 Dr. Katherine Brown South East Sydney Illawarra Area Health Service Wollongong, Australia $1,050 (Year 1 Subaward) $1,725 (Year 2 Subaward) Thanyawee Puthanakit, M.D. HIV-NAT/Thai Red Cross AIDS Research Centre Bangkok, Thailand $7,500 Andrew Carr, M.D. St. Vincent’s Hospital Sydney, Ltd. Darlinghurst, Australia $7,500 (Year 1 Subaward) $7,500 (Year 2 Subaward) Virat Sirisanthana, M.D. Chiang Mai University Research Institute for Health Sciences Chiang Mai, Thailand $15,000 John Chuah, M.B.B.S., B.Sc. Gold Coast Health Service District Miami, Australia $7,500 (Year 1 Subaward) $7,500 (Year 2 Subaward) Kulkanya Chokephaibulkit, M.D. Siriraj Hospital Mahidol Univeristy Bangkok, Thailand $15,000 Basil Donavon, M.B.B.S. Sydney Sexual Health Centre Sydney Hospital Sydney, Australia $5,025 (Year 1 Subaward) $3,525 (Year 2 Subaward) Rossana Ditangco, M.D. Research Institute for Tropical Medicine Muntinlupa City, Philippines $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Poh-Lian Lim, M.D., M.P.H. Tan Tock Seng Hospital Singapore $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) Praphan Phanupak, M.D., Ph.D. HIV-NAT/Thai Red Cross Research Center Bangkok, Thailand $15,000 (Year 1 Subaward) $15,000 (Year 2 Subaward) William Donohue, M.B.B.S. University of Adelaide Care and Prevention Program Adelaide, Australia $2,250 (Year 1 Subaward) $2,175 (Year 2 Subaward) Robert Finlayson, M.B.B.S., Dip Ven Taylor Square Private Clinic Darlinghurst, Australia $450 (Year 1 Program Technical Support Agreement) $6,300 (Year 2 Program Technical Support Agreement) David Orth, M.B.B.S., Dip Ven Gladstone Road Medical Centre Highgate Hill, Australia $6,525 (Year 1 Program Technical Support Agreement) $3,000 (Year 2 Program Technical Support Agreement) Jennifer Hoy, M.B.B.S. Victorian HIV Service, Infectious Diseases Department, Alfred Hospital Melbourne, Australia $7,500 (Year 2 Subaward) Dr. Tim Read Melbourne Sexual Health Centre Carlton, Australia $7,500 (Year 1 Subaward) $6,300 (Year 2 Subaward) Dr. Eva Jackson Blue Mountains Sexual Health and HIV Clinic Katoomba, Australia $3,600 (Year 1 Subaward) $1,725 (Year 2 Subaward) Norman Roth, M.B.B.S., F.A.Ch.S.H.M. Prahran Market Clinic Pty., Ltd. South Yarra, Australia $7,500 (Year 1 Subaward) $7,125 (Year 2 Subaward) Mark Kelly, M.B.B.S. The Prince Charles Hospital AIDS Medical Unit Brisbane, Australia $7,500 (Year 1 Subaward) $7,500 (Year 2 Subaward) Dr. Anuja Kulatunga Northern Territory Dept of Health & Community Services, Sexual Health & Blood Borne Virus Program, Clinic 34 Darwin, Australia $900 (Year 1 Subaward) $975 (Year 2 Subaward) Mun Tong Liang, F.A.Ch.S.H.M. Nepean Sexual Health Clinic Sydney, Australia $1,875 (Year 1 Subaward) $1,350 (Year 2 Subaward) Simon Mallal, M.D. Royal Perth Hospital/Department of Clinical Immunology and Immunogenetics Perth, Australia $7,500 (Year 1 Subaward) $7,500 (Year 2 Subaward) Anne Mijch, M.B.B.S. Victorian HIV Service, Infectious Diseases Department, Alfred Hospital Melbourne, Australia $7,500 (Year 1 Subaward) Darren Russell, Medicine Cairns Sexual Health Service Cairns, Australia $5,925 (Year 1 Subaward) $7,600 (Year 2 Subaward) Dr. David Smith Sexual Health and AIDS Services Lismore, Australia $7,500 (Year 1 Subaward) $5,775 (Year 2 Subaward) David Sowden, M.B.B.S. Nambour General Hospital Nambour, Australia $7,500 (Year 1 Subaward) $7,500 (Year 2 Subaward) Sharon Taylor, C.N.C. Hunter New England Health, Bligh Street Clinic, Tamworth Sexual Health Service Tamworth, Australia $900 (Year 1 Subaward) $675 (Year 2 Subaward) Ian Woolley, M.B.B.S., F.R.A.C.P. Monash Medical Centre, Clayton Melbourne, Australia $3,450 (Year 1 Subaward) $4125 (Year 2 Subaward) TREAT Asia Quality Assurance Scheme Matthew G. Law, Ph.D. National Centre in HIV Epidemiology and Clinical Research University of New South Wales Sydney, Australia $161,468 $119,623 (2006) TREAT Asia Studies to Evaluate Resistance Matthew G. Law, Ph.D. National Centre in HIV Epidemiology and Clinical Research University of New South Wales Sydney, Australia $165,530 $156,297 (2006) Nagalingeswaran Kumarasamy, M.D., M.B.B.S., Ph.D. YRG Centre for AIDS Research and Education, VHS Chennai, India $50,000 Sanjay Pujari, M.D. Institute of Infectious Diseases Pune, India $50,000 Adeeba Kamarulzaman, M.B.B.S., F.R.A.C.P. University of Malaya Clinical Investigation Center Kuala Lumpur, Malaysia $50,000 Christopher Lee, M.B.B.S., M.R.C.P. Sungai Buloh Hospital Sungai Buloh, Malaysia $50,000 Thira Sirisanthana, M.D. Chiang Mai University Chiang Mai, Thailand $50,000 Somnuek Sungkanuparph, M.D. Ramathibodi Hospital Mahidol University Bangkok, Thailand $50,000 Praphan Phanuphak, M.D., Ph.D. Thai Red Cross Research Center Bangkok, Thailand $50,000 TREAT Asia Awards Treatment literacy project Pharozin Pheng Cambodian People Living with HIV/ AIDS Network (CPN+) Phnom Penh, Cambodia $10,388 Tenth Bangkok Symposium on HIV Medicine Prapahan Phanuphak, M.D., Ph.D. HIV Netherlands, Australia, Thailand Research Collaboration (HIV-NAT) Bangkok, Thailand $20,000 Support for special analyses of epidemiological and clinical HIV research Preeyaporn Srasuebkul, M.S. University of New South Wales Sydney, Australia $48,345 Global Initiatives Awards Promotion of early CMV retinitis detection: A definitive teaching tool David Heiden, M.D. Pacific Vision Foundation San Francisco, CA $8,200 Emergency operating support Felix Mwanza Treatment Advocacy and Literacy Campaign Lusaka, Zambia $2,000 amfAR Annual Report 2007 Catherine O’Connor, M.B.B.S., F.A.Ch.S.H.M. Livingstone Road Sexual Health Centre Marrickville, Australia $1,575 (Year 1 Subaward) $750 (Year 2 Subaward) 21 Global Initiatives David Ellis, M.B.B.S. D.A. Ellis Pty, Ltd. Crofts Harbour, Australia $1,500 (Year 1 Program Technical Support Agreement) $1,050 (Year 2 Program Technical Support Agreement) E P U B L I C P O L I C Y arly on in the AIDS epidemic, amfAR established itself as both an effective proponent of comprehensive research, treatment, and prevention programs and a vigorous opponent of HIV-related stigma and discrimination. Working with partners in the AIDS community and allies in Congress, the Foundation was instrumental in securing the passage of key legislation, including the Hope Act of 1988, the Ryan White CARE Act of 1990, and the Americans with Disabilities Act of 1990. To this day, that legislation forms the bedrock of the national response to HIV/AIDS. HIV/AIDS, including 1.2 million Americans, much work remains to be done to shape domestic and international policies that adequately address HIV research, treatment, prevention, and the protection of the rights of people living with HIV/AIDS. Informed by thorough research and analysis, amfAR is a highly respected advocate of evidence-based and compassionate HIV/AIDS-related public policy. amfAR’s current advocacy priorities include: • Securing necessary increases in funding for AIDS research, prevention, treatment, and care; • Advancing a research and policy agenda that addresses the social, structural, and economic factors that contribute to the HIV/AIDS epidemic; “At least a quarter of people in the U.S. living with HIV are quite unaware of their infection. And people who are unaware of their infection are likely to transmit HIV to others.” At the briefing, actress Gloria Reuben, who played an HIV- • Advocating appropriate federal funding for the U.S. positive physician assistant on the television drama E.R. and is now an AIDS activist, called for increased awareness and dis- government’s global HIV/AIDS programs; • Implementing an evidence-based, national HIV prevention cussion of HIV. “The thing that disturbs me most is to witness HIV become pandemic in the black community,” Reuben said. strategy; • Repealing the current ban on federal funding for syringe “AIDS is the number one killer of black women aged 25–34. How could this be?” exchange programs; • Expanding access to treatment and care; and In February 2007, amfAR co-sponsored a conference in Los • Safeguarding legal protections for people with HIV/AIDS. Angeles, It’s All About M.E.E. (Motivation, Education, Empowerment), which was organized by the Black AIDS Institute to address the HIV and Vulnerable Populations spread of HIV among African-American women. Women make up nearly half of all HIV infections worldwide, according to the Joint United Nations Programme on HIV/AIDS Harm Reduction and Prevention (UNAIDS). In the U.S., the number of new infections among Numerous scientific studies—including many supported by women has increased steadily since the mid-1980s. Women amfAR—have shown conclusively that the distribution of of color have borne the brunt of this increase, with African- sterile syringes is effective in preventing the transmission of American women accounting for two-thirds of new AIDS HIV and other infections among injection drug users, without cases among women in 2005. Young women are increasingly increasing drug use. Despite the evidence, the U.S. persists vulnerable: by 2005, girls represented 43 percent of teenage in banning the use of federal funds for syringe exchange and infections. other harm reduction measures. To commemorate World AIDS Day on December 1, 2006, Although the federal ban remains firmly in place, advocates amfAR co-sponsored a congressional briefing titled HIV/AIDS in achieved a major victory in 2007 in Washington, D.C., where the U.S.: Focusing on the Needs of African-American Women. Panel- one in 20 residents is living with HIV. In 1998, the federal ists presented scientific and epidemiological updates and policy government banned the District of Columbia from using local recommendations, while testimonials from African-American taxpayer dollars to fund its own syringe exchange programs. women and young people illustrated the profound impact that Since the ban was imposed, amfAR has provided grants to HIV has on daily life for so many American families. The briefing support syringe exchange in Washington, D.C., and has been was co-sponsored by the Sexuality Information and Education vocal in its opposition to the ban. In 2007, both the House and Council of the United States (SIECUS) and AIDS Alliance for Senate finally removed the restrictive legislative language, an Children, Youth, and Families. advocacy triumph that was a decade in the making. amfAR Annual Report 2007 With more than 33 million people worldwide living with 23 Public Policy A Rethinking the Ground Rules for HIV Testing “ t least a quarter of people in the U.S. living with HIV are quite unaware of their infection,” said Dr. Kenneth Mayer, an HIV specialist who serves on amfAR’s program board. “And people unaware of their infection are likely to transmit HIV to others.” In the hope of getting more people to be tested for HIV and thereby reducing rates of transmission, in the fall of 2007 amfAR announced its support for making HIV testing a part of routine healthcare. The move followed a shift by the Centers for Disease Control and Prevention, which abandoned previous guidelines that had called for HIV testing to be amfAR Annual Report 2007 24 performed only in tandem with counseling. Debates have surrounded HIV testing for many years, remembered Peter Staley, an amfAR program board member. In the 1990s, “we were still living in a time of HIV exceptionalism,” he said. “HIV was not treated like other conditions or other sexually transmitted infections because of the stigma involved and the shock associated with getting a positive reading from an HIV test.” “But after the advent of highly active antiretroviral therapy, society came a long way in its perception of HIV,” Staley explained. “One of the things that dawned on the medical establishment and activists was that HIV exceptionalism Public Policy in itself says stigma. Why shouldn’t this be like a hepatitis test, or cystic fibrosis? There aren’t all these restrictions on how to diagnose cystic fibrosis, nor should there be for HIV.” In his own practice, Dr. Mayer encountered the problems presented by restrictions on HIV testing. “By creating a special system of having to get explicit and informed consent and having to mandate specific kinds of counseling and testing, impediments were being created for healthcare workers,” he explained. In recent years, concerns about patient confidentiality have been assuaged by broad new federal laws. After a careful review of the evidence, amfAR’s Public Policy committee and staff reached a decision in early 2007. “We felt that it would lead to broader testing to uncouple the medical process—the blood test—from the social process— counseling,” said Staley. “Ultimately that would lead to saving more lives.” This amfAR-supported mobile unit in New York City provides HIV testing, syringe exchange, and other harm reduction resources to those who most need them. In November 2006, amfAR sponsored the 6th Annual Harm Reduction Coalition Conference, titled Drug User Health: The Politics and the Personal, in Oakland, California. In February 2007 and in collaboration with the Community HIV/AIDS Mobilization Project (CHAMP), amfAR co-sponsored and participated in the planning of an HIV prevention research advocacy workshop in Los Angeles to educate community advocates about the latest research and the need for improved prevention strategies and technologies. amfAR also organized a congressional briefing in March 2007 to educate legislators and their staffs about the calamitous influence of injection drug use on the spread of HIV throughout Asia and Eastern Europe. Entitled Drug Use Fueling Epidemics in the East, the briefing featured a panel of international experts who identified increased injection drug use and a lack of harm reduction programs as drivers of the epidemic in those regions. Duong Truong Thuy of Vietnam, a member of TREAT Asia’s Asian Community for AIDS Treatment and Advocacy (see page 19), submitted a written statement to the briefing. Thuy, who was unable to attend in person because of U.S. policy restricting visas for people with HIV, described his experiences as a former injection drug user and the need for outreach for drug users in Vietnam. “A lot of people think ‘harm reduction’ sounds criminal,” he wrote. “But isn’t it more criminal when you know how to save people’s lives and you don’t do anything about it?” amfAR continues to support the only annual national survey of syringe exchange programs in the U.S., which is published in the CDC’s Morbidity and Mortality Weekly Report. And through a contract with the New York State Department of Health’s AIDS Institute, the Foundation administers the distribution of harm reduction supplies to the state’s 17 authorized syringe exchange programs. These programs, which also provide counseling, prevention education, and medical and addiction treatment referrals, have served more than 121,000 participants. Candace Webb, Danielle Warren-Diaz, and actress Gloria Reuben. Protecting Scientific Integrity Relief, which has brought treatment to millions in developing amfAR’s Public Policy program is guided by the need to countries, has solid bipartisan support. amfAR will continue to espouse and enact AIDS policies that are firmly rooted in support these measures and other evidence-based policies that scientific evidence rather than politics and ideology. The effectively address the treatment and prevention of HIV in the Foundation is a founding member of the Caucus for Evidence- U.S. and around the world. Based Prevention, a group of more than 60 U.S.-based NGOs and their international partners dedicated to the promotion of evidence-based policies for HIV prevention in the United States and internationally. amfAR is also a member of the Integrity of Science Working Group, which is spearheaded by the Union gies Project, and the Coalition to Protect Research, a group 2007 PUBLIC POLICY GRANTS AND AWARDS of scientific, medical, and health organizations dedicated to All projects listed below were supported by amfAR promoting public health through research, including sexual during the period October 1, 2006, to September health research. 30, 2007. of Concerned Scientists and the Reproductive Health Technolo- A Shifting Landscape? There are encouraging signs that the political climate is shifting in favor of more progressive HIV/AIDS policies. For the first time in a decade, Washington, D.C., will be able to use its own funds to support syringe exchange and other harm reduction programs. Some members of Congress are also pressing for increases in biomedical research, as well as an end to travel restrictions that hinder the entry of HIV-positive foreigners into the U.S. Additionally, the President’s Emergency Plan for AIDS National Black Women and HIV/AIDS Conference Phill Wilson Black AIDS Institute Los Angeles, CA $50,000 Research Advocacy for HIV Prevention: Skills & Challenges for Activists Julie Davids Community HIV/AIDS Mobilization Project (CHAMP) Providence, RI $3,000 Syringe Exchange in the US: State of the Art and State of Public Support Don Des Jarlais, Ph.D. Beth Israel Medical Center New York, New York $75,000 amfAR Annual Report 2007 HIV’s impact on black women and families. Panelists included (left to right) 25 Public Poliicy amfAR co-sponsored a World AIDS Day congressional briefing examining T E D U C ATION AN D INFORMATION he dissemination of new knowledge gained from AIDS research is integral to all of amfAR’s programs. But keeping AIDS in the public consciousness and keeping healthcare professionals abreast of continually evolving HIV treatment and care strategies requires an ongoing commitment to education and the distribution of information. Through its Education and Information program, amfAR provides updates on the latest research and treatment advances to physicians and other healthcare providers, and helps the public stay informed through the media, public awareness campaigns, the Internet, and a range of publications. “It is important for us to remember that we’re whole people, that we’re not just a virus.” Continuing Medical Education Each new development in HIV treatment alters the complex calculations that physicians must grapple with in their daily decision making. amfAR is one of only a handful of nonprofit organizations accredited by the Accreditation Council for Continuing Medical Education to provide HIV education credits to physicians. amfAR’s professional education courses benefit physicians, nurses, nurse practitioners, physician assistants, and others involved in caring for people with HIV. But the ultimate benefit resides in improved care for patients who must contend the power of exercise, of just trying to live your whole life as a with drug side effects, and lifelong monitoring and adherence whole human being.” to treatment. amfAR co-sponsored the 2nd National Conference on Methamphet- patients is drug resistance. Over time, a patient’s virus will amine, HIV, and Hepatitis in Salt Lake City in February 2007. The inevitably mutate and evade the effects of one or more of meeting brought together public health officials, physicians, the drugs in a given regimen. However, new drug classes and advocates, researchers, and law enforcement personnel to find evolving treatment strategies offer hope for patients who have ways to diminish the influence of crystal meth use on HIV and exhausted other treatment options. From June to September hepatitis incidence. CME credits were provided to participating 2007, amfAR presented a series of educational programs for physicians. physician assistants and nurse practitioners entitled Improving HIV Treatment Outcomes and Care for the Treatment-Experienced Think Tanks and Symposia Patient. Attended by more than 550 participants and featuring The long-term success of HIV prevention and treatment is case-based interactive presentations integrated with study inextricably linked with educational programs that meet data, the CME series was held in Raleigh-Durham, North current and future needs. To identify and plug education gaps, Carolina; Albany, New York; San Diego; Los Angeles; Denver; amfAR organized a series of eight think tanks in 2007 that Atlanta; Indianapolis; Portland, Oregon; Kansas City, Missouri; brought together health experts, community members, and care and Boston. providers from around the country to share best practices and develop strategies and goals. Separate sessions for clinicians amfAR also conducted community forums on drug resis- tance in 2007—one in Seattle in January and a second in Las and community members were held in San Francisco, New York, Vegas in May—titled Understanding Antiretroviral Therapy: Lessons Chicago, and Miami. for the Treatment-Experienced Patient. Each forum was attended by nearly 100 participants, including treatment-experienced partnered with Columbia University’s Mailman School of Public individuals, caregivers, social workers, educators, nurses, and Health to organize a symposium entitled HIV Prevention Among other healthcare providers. Support for the meetings was Men Who Have Sex with Men. The symposium, which took place in provided by Boehringer Ingelheim and Gilead Sciences. late November, featured an international panel of experts who discussed the epidemiology of HIV among men who have sex At the Seattle community forum, panelists discussed new In commemoration of World AIDS Day 2006, amfAR treatment strategies, recently approved drugs, and the with men (MSM), as well as prevention methods, prevention importance and difficulties of adherence—but they also challenges among African-American MSM, and healthcare for emphasized that treatment is only one aspect of living with HIV. MSM in the developing world. “It is important for us to remember that we’re whole people, that we’re not just a virus,” said patient advocate Pat Migliore. Spreading Knowledge, Raising Awareness “We have to be really responsible as patients to make sure that In recent years, efforts to institute abstinence-only sex educa- we round out the rest of our lives. I’ve heard it again and again tion in schools across the U.S. have led to a dangerous lack of in here tonight—the power of prayer, the power of spirituality, knowledge among many young people about HIV transmission amfAR Annual Report 2007 With drug use continuing to exacerbate HIV infection rates, 27 Education and Information One of the most serious challenges for longtime HIV S Sharing Expertise on Treatment-Experienced Patients treatment, which have helped to extend the lives eattle internist Dr. Peter Shalit sees hundreds of patients in his of people with the virus, have fueled a widening medical practice, about half of them living with HIV. Over the belief that HIV/AIDS is no longer a serious illness. course of his career as an HIV specialist, Dr. Shalit has worked These developments highlight the ongoing need to keep his patients healthy, but his choices get much more for accurate, science-based public information on complicated when they develop resistance to one or more of HIV/AIDS. their drugs. amfAR’s print and electronic publications, “It used to be until a couple of years ago that we couldn’t really do anything for people [with drug resistance] except to which are distributed in the U.S. and around the world, help to fill this information gap by providing say, ‘stay on what you’re on or we’ll give you a cocktail that doesn’t make you sick, up-to-date news on research developments, HIV/ and hopefully things will kind of stay stable for a while’,” Dr. Shalit said. AIDS policy, the social and economic impact of Today, more than 20 anti-HIV drugs are available, but Dr. Shalit and others who amfAR Annual Report 2007 28 and prevention. In addition, recent advances in HIV the epidemic, and HIV prevention. amfAR News is care for treatment-experienced patients still confront a daunting challenge. “The published twice a year and distributed to 70,000 folks who have resistant viruses are not a majority,” he explained, “but treatment people. A monthly email newsletter reaches more for them is more sophisticated.” than 40,000. The TREAT Asia Report, which includes Along with a small group of HIV experts, Dr. Shalit (son of film critic Gene Shalit) news on the Asian epidemic and updates on Education and Information served on amfAR’s planning committee for the Continuing Medical Education amfAR’s TREAT Asia program, is a quarterly (CME) series entitled Improving HIV Treatment Outcomes and Care for the Treatment- newsletter that reaches an international audience Experienced Patient (see page 27), and took a leadership role in creating the commu- of 15,000. nity education portion of the program. He also assisted with content development The Foundation’s website, www.amfar.org, and spoke at the physician and community forums that addressed the topic. “This receives an average of 55,000 visitors each month. is an issue a lot of providers are unaware of,” he said. “I try to educate them. It is Updated daily, the site explains AIDS research and easy to harm someone by giving them a new regimen and having it fail. policy developments, and disseminates a wealth of “This virus is very crafty. It takes advantage of any little opening that a person information on HIV prevention, testing, epidemiol- will give it,” Dr. Shalit said. “But my personal feeling is that with proper treatment, ogy, and amfAR’s programs and activities. amfAR someone with HIV should have the same life expectancy as someone without HIV.” also develops and distributes reports, fact sheets, and issue briefs on a wide range of HIV/AIDS research and policy issues. In addition to treating hundreds of HIV-positive men in his Seattle practice, Dr. Peter Shalit educates healthcare professionals on the latest strategies for treatment-experienced patients through amfAR’s Continuing Medical Education programs. “With proper treatment, someone with HIV should have the same life expectancy as someone without HIV.” amfAR Annual Report 2007 Health Commissioner Dr. Thomas R. Frieden help launch the NYC Condoms program. In spring 2007, amfAR sponsored a national survey to Post, the International Herald Tribune, the San Francisco Chronicle, assess public perceptions of women living with HIV/AIDS. The New Yorker, The Advocate, Reuters, the Associated Press, The results showed pervasive negative views of HIV-positive CNN.com, LATimes.com and Forbes.com. women and a high level of discomfort in interacting with On World AIDS Day 2006, amfAR chairman Kenneth Cole them. Many of the responses displayed a lack of knowledge appeared on the Discovery Health television network in public of how HIV is transmitted and misplaced fear of contracting service announcements about HIV/AIDS. He also participated the virus that indicate a pressing need to scale up prevention in exclusive video and audio interviews on the network’s web- education efforts. Conducted by Harris Interactive for amfAR, site and in an iTunes podcast. Also for World AIDS Day, amfAR the survey questioned nearly 5,000 respondents aged 18–44 CEO Kevin Robert Frost appeared on New York’s WCBS TV and covered HIV risk and responsibility, the impact of gender- news to speak about the urgency of addressing the epidemic. based violence, and women’s access to healthcare and health amfAR’s ability to make its voice heard internationally is information, as well as attitudes towards HIV-positive women. considerably enhanced by the active participation of public The survey was made possible by grants from Broadway Cares/ figures. Celebrities from the fields of music, film, fashion, and Equity Fights AIDS and the M•A•C AIDS Fund. fine arts generously donate their time, talents, and resources to advance amfAR’s mission and raise funds in support of Beating the Drum it. amfAR is especially indebted to Dame Elizabeth Taylor In an era of short attention spans and furious competition for and Sharon Stone for their innumerable contributions to the the media spotlight, keeping AIDS on the public radar screen Foundation and the cause of AIDS research. Others who gen- requires continual outreach to the media. As a prominent voice erously lent their voices and support in 2007 include Woody on HIV/AIDS for more than 20 years, amfAR is sought after by Allen and Soon-Yi Previn, Tracy Chapman, Richard Gere, Paris the media for expert commentary on AIDS research and policy Hilton, Cheyenne Jackson, Eve Jeffers, Milla Jovovich, Beyoncé issues. In 2007, amfAR was repeatedly called on to provide Knowles, Liza Minnelli, Kylie Minogue, Natasha Richardson, expert commentary on the latest research findings. Outlets that Julian Schnabel, Liz Smith, Stanley Tucci, Dita Von Teese, featured amfAR and its researchers included The Washington Harvey Weinstein, and Michelle Yeoh. 29 Education and Information amfAR Chairman Kenneth Cole and New York City G I V IN G amfAR’s accomplishments in the fight against AIDS would not be possible without generous support from individual and institutional amfAR Annual Report 2007 30 donors. There are many ways you can join us in our efforts to end the global AIDS epidemic. Donate online at www.amfar.org Write a personal check. Giving Make a gift in honor or memory of a loved one. Include amfAR in your will or other estate plans. Join the “Friends of amfAR” monthly giving program. Ask your employer to match your gift. Designate amfAR in your workplace giving program. Give a “Partners for the Cure” gift of $1,000 or more. Consider a gift of stock or other assets. Attend or sponsor an amfAR benefit event. Donate goods or services. For more information, call us at (212) 806-1600 or e-mail [email protected] Individual Giving Generous support from individual donors forms the backbone of amfAR’s efforts to control and eradicate HIV/AIDS. The following individuals and families contributed or raised $1,000 or more between October 1, 2006, and September 30, 2007. amfAR acknowledges with gratitude the thousands of other donors whose generous contributions, tribute gifts, and benefit event ticket Lee and Penny Anderson Gabriel and Ann BarbierMueller Angela Barrett Yannis Bilquez Jaka Bizilj David C. Bohnett and Tom Gregory Jean R. Boulle Hermann Bühlbecker Tim Byrne Luigi Caiola and Sean McGill Donald A. Capoccia Roberto Cavalli Fabrizio Cerina R. Martin Chavez, Ph.D. Robert and Suzanne Chute Giuseppe Cipriani Kenneth and Maria Cole Ugo Colombo Kenneth and Patricia Crews Rex Cumming Sindika Dokolo Vladislav Doronin Umar Dzhabrailov John and Jennifer Eagle Amir and Maria Ecker Walter and Laura Elcock $10,000–24,999 Frank Aldridge, III and Brooke Aldridge Omar Amanat Louis Andy Paul Arata and Scott Foster Nicholas Augustinos and Curt Kirschner Steven and Carrie Becker Christian J. Beherman Jeff Berg Christina Bloom Carla Bruni Vincent Calcagno David M. Carrillo and Lisa Sardegna Tracy Chapman Vikram Chatwal and Priya Sachdev Steven and Alexandra Cohen Dennis and Janette Mohammed Y. El-Khereiji Jeff and Regen Fearon Glenn R. Fuhrman Gladwin Gill, M.D. Kenneth Goss and George Michael Timothy G. Hanlon Michael Hirtenstein Marguerite S. Hoffman James C. Hormel Anita M. Jaffe Bob and Susan Kaminski Maurice Kanbar Donna Karan George and Karen Kollitides Mathilde Krim, Ph.D. John and Carol Levy Michel Litvak Sheila W. 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Blakemore Kurt and Margot Bloch Daniel and Laura Boeckman Joseph Boerjes William and Clare Bohnett Brian R. Bolke George and Eleanor Bollag Paul and Maxine Bradley Peter Bradley and David R. Krimm Scott Brady Brent Brake Philip D. Brandt Stephen Brauer Zev and Mayling Braun Arthur L. Brown Brent Brown Constance A. Brown David S. Brown Gavin Brown Lloyd R. Brown Robert Bryan and Julie A. Jensen Todd Buchanan Laurie Burns James and Debbie Burrows Judd Burstein Barbara F. Buzzell Molly Byrne Renee Cafiero Walter M. Cain Karen Campbell Jonathan S. Canno Sherman R. Card Stephen P. Carlino and Dennis R. Fee Frank Carucci Robert and Dolores Cathcart Tracy B. Cather Satjiv S. Chahil 31 Giving $25,000+ amfAR Annual Report 2007 purchases have helped bring us closer to our goal of a world without AIDS. amfAR Annual Report 2007 32 Giving Matthew Chang Martin Samuel Checov Cameron A. Clarke Robert W. Clausen, M.D. Michael P. Clifford and Robert Levy Anthony and Catherine Clifton Stewart and Kimberley E. Cohen Kim Colby Eric Coleman Scott Coleman Michael and Linda Connelly Patrick and Ginger Connolly Albert B. Connor Alfred and Alvina Contarino Frank P. Conway Joseph H. Cook Andrew and Wendy Cookler Nancy and Bruce Cooper Richard and Fara Copell Michael Corman George B. Cotkin Tom Crane and Richard Louie Christopher Crowley William L. Cruise Graham and Kimberly Culp Mimi F. Cummings J. Patrick Curry Timothy and Denise Curry Michelle Curtis Allen and Mason Custard Steven Czekala, D.D.S. Don and Barbara Daseke Joan C. Davidow Sean Davis Lori and Richard Day Juliet de Baubigny Michael and Deborah Dean Glynn and Sonia Decoteau Alan S. Dejarnette Salvatore Delorenzo David and Sylvia Dennison Craig Deodede Victoria A. Derdivanis Traci Des Jardins John Desmarteau, M.D. and Alvin E. Thompson Henry Detering William and Heidi Dillon Michael J. Dion Salvatore E. Dirschberger D. 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Kourlas Ronya and George Kozmetsky Michael and Shelley Krall Ella Krasner Peter and Lisa Kraus Robert W. Krause, M.D. Daniele Kucera and Jeffrey M. Khaner Mark J. Kulkis Frances E. Kumashiro Jeff and Terry Kurz William Kwan Chal and Chuok Kwon Brian and Rachel Ladin Jonathan Lamensdorf William and Mary Lamont Maree B. Larson Mark H. Laughlin Frank and Kathleen Lauinger Jeff Leatham Sonia Lee and Alan M. Grumet Lois A. Lenahan Edward C. Lenhart Carl Levine Dominique Levy Jay and Sharon Levy Scott and Allison Levy F. Bruce and Diana Lewis Erica Lieberman Richard Linebaugh John S. Lipsey and John E. Alexander Steven Lisker Michael P. Liskowycz Jeff Little William E. Little, Jr. and Helen Little Ming S. Liu William and Michelle Lockhart Arthur L. Loeb John Lomibao George M. Lorenzo Joseph and Susan Losak Jesse and Patricia Lovejoy Mr. and Mrs. Lawrence Ludgus Francis A. Luttmer Ruth Luttmer 2007. More than 20 amfAR supporters took a ten-day trek through the Namib Desert of Namibia and learned firsthand about the AIDS crisis in sub-Saharan Africa. Trekkers raised $251,000 for amfAR’s programs, led by Peter McManus of Los Angeles who generated $40,000. Helena Buzzeo Sushama Cisson Derek Cordier Rainer Facklam Julie Gilhart Patti Gomes Glenn Isaacson Rowena Johnston Natalie Kates Harry Kubetz Maura Lee Peter McManus Brandon Palacio Dexter Phillip Ramneek Rikhy Sandra Roy Danielle Schofs John Tarro Albert Vaccari Michael Walsh Trekkers rest at an abandoned farmstead. Bobby B. Lyle Frank and Joan Macero Thomas S. Magaraci Todd J. Maldonado Irving and Harriet Malitson Eric C. Malley Carey C. Maloney and Hermes Mallea Michael D. Manshel Claire P. Mansur and John P. Ryan Steven Mao Robert Marc Norman Marks Bruce and Gloria Martindale Patricia J. Matson William M. Matthes Christine Mattsson McHale and John McHale David J. Maue and Dave Gaudette T. Kirk May, Jr. Douglas G. Mayberry Kenneth H. Mayer, M.D. Mario and Luciana Mazzola Alexander McAfee Thomas McArdle Timothy F. McCabe Mark N. McConnaughay William and Patty McCormack Andrew McFadden Cappy and Janie McGarr James J. McInerney and Gary R. Fafard Gordon N. McLeod and Melanie Grisanti Casey and Megan McManemin Jay McNamara Suzanne R. McPhee Rochelle McReynolds David R. McShane Victoria L. Meakin Kathryn D. Meister Bill Melamed, Jr. Jeffrey D. Meleski Ron and Wendy Meltsner Alvaro R. Menendez Richard and Ronay Menschel Manuel R. Merjil Julie Mesa Frank L. Miceli Janet G. Michaels Neli P. Mihalkova Frank and Maryann Mihalopoulos amfAR Annual Report 2007 amfAR staged its third physical challenge fund-raising event, Trek amfAR in Africa, in May Morton Milder Howard J. Miller Fred and Susan Miller William and Patrica Miller Judith R. Minor Ronald P. Minutella Presley Mock, M.D. and Lynn Mock Ronald and Kerry Moelis Warren Moen Cynthia Molstad Elena J. Mondini Robert Montagnese Susan B. Montgomery Alona Moore David E. Morales, M.D. Michael D. Morgan Bruce and Donna Morse Jenny S. Morton and Mike Wilson John Motondo Jenny Mullen Don Mullins John and Marilyn Murbach Jerry Nahay Edward Tyler Nahem Marty Nealon and Richard Aellen Robert O. Newbury Mark E. Newell and Jo Ann L. Newell Adina M. Newman Paul Newman and Joanne Woodward David and Antigoni Newton Connie Ngai Mark Niquist Paula A. North Rosie O’Donnell David J. Olesker Joe Olivo and Jeff Wiggins Jay W. Oppenheimer Tom Osborne Mary A. Ostrom M. Chris Overby, M.D. David T. Owsley Robert K. Ozanne Jay and Ruthie Pack Susan L. Page Sonia G. Palacio Maxwell G. Paley and Gregory J. Corrales Daniel and Amy Palladino Alvin L. Park John and Diana Park Joan Parker Gary and Pamela Patsley C. Sprague Paynter Nivia Pedroza Thomas E. Pedulla David N. Pennington Roberta Perez Christopher A. Perrault Robert Perri and John J. Mini 33 amfAR Donors Giving Trek amfAR amfAR Annual Report 2007 34 Giving Jack M. Perry, Esq. Richard and Lisa Perry Marjorie L. Pflaum Kevin P. Philbin Eric A. Pike David N. Pincus Alden Pinnell Michael C. Pinson James C. Pirius Barry and Penny Platnick Gloria Polastri Richard and Karen Pollock Daniel J. Ponder Patricia Pope Adrianna M. Pope Sullivan Fern Portnoy Kevin M. Poulos Joe Powell Nani B. Powers Randy M. Presuhn and Timothy Nguyen Aleksey Pryadko Jach Pursel Kelli and Allen Questrom Robin O. Quivers Seth D. Radwell Jerome and Karen Radwin William and Marcia Rafkin John A. Ramelli, III Jeanne G. Rand Allison Rao Karl and Carolyn Rathjen Jordan H. Rednor Peter S. Reichertz Brian Reid and Brett Brenner Jose R. Reyes Anthony J. Richardson Temple S. Richardson Walter Rieman in Memory of Tom Stoddard Leonard and Peggy Riggs Timothy A. Robert Bonnie G. Robins James E. Rocco David Rockefeller Howard Roffman and Duane Waters Leila A. Rogalsky Gregory and Lysa Rohan George Rosenfield and Christopher Hoover Brian Roth Naomi Rothschild Sandra A. Roy Iris R. Rubinfield Frances E. Ruddell Peter and Sally Rudoy Lawrence Ruff James Saakvitne and Chi Yuen Chow Mitchell Salaway Steven S. Saleh Dorian P. Sarris Mitchell and Bonnie Sassower Tony M. Scelza Robert Schaffer Dennis J. Schank Leonard J. Schaustal, Jr. Roger E. Schechter and Craig P. Ziskin Steven V. Schmitz Ronald I. Schnur Harry Schoening Danielle Schofs Katie Schwab Armond and Cynthia Schwartz Carol S. Schwartz Daniel and Barbara Schwartz John Schwartz Sherwood and Mildred Schwartz Steven T. Schwarz and Miles Kahler Gerald J. Seibel James R. Seitz, Jr. Neil L. Selinger and Rima Grad Kristen Sellgren and David J. Ennis Dennis Senovich Leslie Serchuck, M.D. David M. Serna Adam Shankman Lionel Shaw Jesse B. Shelmire, IV and Michelle Shelmire Rodney Sher and Mary Tobin William F. Sheridan Allan P. Sherman Timothy and Beth Shields James Shimizu James C. Shingle Gresham Jay Shinn, Jr. and Tim Hurst Tina Shone Stephen and Wendy Siegel Douglas Sills and Todd Murray Cameron Silver Albert and Kimberly Silvera Mervyn and Deborah Silverman Lee Simerman, M.D. Robert G. Simon and Gilles DeVoe John and Betsy Simons Patricia J. S. Simpson Rosalyn Sinoway Catherine H. Skove Eric and Susan Smidt Frank C. Smith Mark D. Smith and John O’Keefe Joseph Sokolosky Nira Soomekh Murat H. Sor, M.D. James E. Southworth Stan Sroka Christina and Sean St. Clair Peter Staley and Gary Schwartz Kathryn and Timothy Statton Sue E. Stedman Alan and Cathy Steel Tom and Blake Stephenson Andrew T. Stewart Kristin K. Stitz and J. Scott Coleman Paul and Gayle Stoffel Stephen Straty Steve and Emily Summers Greg M. Swalwell Richard F. Swenson Dale and Denice Swift Lucille Swindoll Carol Tacker Robert F. Tannenhauser Pamela Tarro Jason and Leigh Taylor Jim Taylor and Anthony Luongo Julie Taymor Rick and Sandy Thomas Paul Thompson Shirley Thompson Regine Thorre Andrew P. Tobias Gregory A. Tosko Christopher D. Tower John Traina Garry Trudeau and Jane Pauley Ivana Trump Brian C. Trust Stanley Tucci Douglas H. Tucker Richard and Adrienne Tufeld Matthew D. Tumminello Sheldon G. Turley, Jr. Alexander J. Turner Heather L. Turner Richard F. Turner Robert L. Turner Kathleen E. Tyrrell Robert D. Uher Kenneth W. Usher Mandana Vahabzadeh James Vergara Dale E. Verlinger Tom Vinci David and Karen Wacker Gerald and Ellen Wacker Thomas M. Wade Stephen Wagner and Simon Beachley Barry C. Waldorf Darren Walker L. Joseph and Karen Walker Richard and Jennifer Walsh William E. Walsh, Jr., M.D. If you or your organization has been inadvertently omitted from these lists or listed incorrectly, please accept our apologies and contact amfAR at (212) 806-1732 so that we can adjust our records accordingly. Neal Ward Robert L. Warner, M.D. and Larry Bobel Marshall Watson and Paul S. Sparks Steven G. Wedge Edward and Betty Weisberger Don Weiss Marco and Joan Weiss Warren Weitman, Jr. Doris K. Wells John Wendell Mona L. Westhaver Gary and Nina Wexler Francis W. White Hall F. Willkie and Thomas Craveiro Richard A. Wilpon Diane B. Wilsey Aubin E. Wilson Brian Wilson Susan A. Winchell, M.D. John and Barbara Winkelman William T. Winters, Jr. and Adriana Winters Andrew Wise C.R. Wishner Jack and Lynda Withiam, Jr. Myron Wojtowycz, M.D. Derik Woods Sum Wu Timothy Wu Rick Wulff Gordon Youngman Ryan Zanin Larry Zerner and Graciela Renee Edberg David Zippel and Mike Johnson Anonymous (13) Institutional Giving amfAR is grateful to the many institutions large and small that support the fight against AIDS through grants, event sponsorship, cause-related marketing activities, and in-kind contributions. Major corporate support comes from business sectors ranging from film, fashion, and fine arts to financial services and pharmaceuticals. Additional generous support is provided by corporate and Alberta Ferretti SpA Avanti Balenciaga David Bohnett Foundation Bold Films, Inc. Broadway Cares/Equity Fights AIDS, Inc. Cartier, Inc. Chi Eta Phi Sorority, Inc. Chanel, Inc. Chopard Christian Dior Couture Chubb Concerned Parents for AIDS Research The Copley Press, Inc. de Grisogono USA, Inc. Denise Rich Music, LLC Diamond Information Center Diesel, SpA Dubai International Film Festival Dutch Ministry of Foreign Affairs The Eisner Foundation Estee Lauder, Inc. Family Health International Fashion Accessories Benefit Ball Federated Department Stores Foundation Bill & Melinda Gates Foundation GlaxoSmithKline Richard and Rhoda Goldman Fund The Halcyon Company Harry Winston, Inc. Hewlett-Packard Company JG Events Elton John AIDS Foundation Kenneth Cole Productions Krehbiel Family Foundation M•A•C AIDS Fund Merck & Co., Inc. Moët Hennessy The Ambrose Monell Foundation MTV Networks Mymetics Corporation Namakwa Diamonds Limited Nassiri Music Omega Diamonds Parfums Christian Dior The Picower Foundation Plaza Motors of Brooklyn Ltd. Quintessentially Red Pillar Realty LLC Red Ribbon Foundation May Ellen & Gerald Ritter Foundation Roberto Cavalli SpA Rock & Republic Sergio Rossi Skyy Spirits, LLC Sotheby’s Swarovski America Ltd. The Elizabeth Taylor AIDS Foundation Tibotec Therapeutics Time Inc. Trade Associates Group Ltd. Verein AIDS Life Warner Home Video, Inc. Wasserman Foundation The Weinstein Company Wells Fargo Yves Saint Laurent The Ruth/Allen Ziegler Foundation Anonymous (4) $10,000–24,999 The Aliquot Foundation AMC, Inc. Bloomberg Cousins Brett D & DF Foundation DaimlerChrysler Corporation Fund Dallas Market Center Disney Worldwide Services, Inc. Entendre Limited Frechette Family Foundation Gap Inc. Jean Paul Gaultier Gilead Sciences, Inc. The Hagedorn Fund The Helene Foundation Initial Entertainment Group The Karma Foundation Laurie Kayden Foundation John & Maria Laffin Trust Leibowitz and Greenway Family Charitable Foundation Carol Anne Levy Foundation Liz Claiborne, Inc. Louis Vuitton Merchandise Mart Properties, Inc. The Non Nobis Solum Foundation, Inc. Park Place Motorcars Adolph and Ruth Schnurmacher Foundation, Inc. Walter H. & Phyllis J. Shorenstein Foundation Star Entertainment Stephen Friedman Fine Art StepUp Commerce, Inc. Talcott Communications Corporation The Tides Foundation Title Associates Torii Pharmaceutical Company Waldman Bros. Theodore & Renee Weiler Foundation, Inc. Williams-Sonoma, Inc. Anonymous $1,000–9,999 2c design Abbey Properties, LLC The Active Network Adelson Family Foundation The AEG Family Foundation American Express Foundation Fred & Catalina Aranas Family Foundation Astec Power AT&T California Avrum Katz Foundation Azzaro Bay Area Physicians for Human Rights BCM USA, LLC Bennack-Polan Foundation Bergman, Walls & Associates, Ltd. Bernhardt Showroom BJ’s Home Accents, Inc. BlackRock Financial Management, Inc. Blue Mountain Arts Boehringer Ingelheim Pharmaceuticals Brian E. Boyle Charitable Foundation Bridges/Larson Foundation Bulgari UK Bungalow, LLC Cable Positive, Inc. Carbon de Luxe Cars4Charities Charity Folks Chelsea Eye Associates CHIS, Inc. Christian Dior Chubb & Son, Inc. Citibank Private Bank Cloud 9 of St. Stephen’s Church Colorscope Columbia University Common Cents New York, Inc. Community Foundation of New Jersey Craig Nealy Architects LLP Crawford Communications, Inc. CRR Ventures, LLC David Kleinberg Design Associates The Irene Diamond Fund Diesel U.S.A., Inc. Discovery Communications Douglas Foundation Duro Dyne National Corporation Edgell Communications, Inc. Edward Sulzberger Foundation, Inc. Thomas and Jeanne Elmezzi Foundation Elmwood Country Club Nora Ephron and Nicholas Pileggi Foundation Equinox Foundation, Inc. Estilo, Inc. Extraordinary Investors, Ltd. Feldman Family 1995 Charitable Lead Trust Fine Lines Co. FJC Flamm Family Foundation Flaxman Family Charitable Trust Fragments Collection, Inc. Fred B. Bearden, III & Associates, Inc. Freeman Decorating Company The Abraham Fuchsberg Family Foundation, Inc. The Leo & Eva Gans Foundation, Inc. Ganz Inc. Garibaldis on Presidio, Inc. Gay Men’s Health Crisis, Inc. General Maritime Corporation George Little Management, Inc. GES Exposition Services 35 Giving $25,000+ amfAR Annual Report 2007 family foundations and by a wide range of civic associations, social clubs, cooperatives, schools, and churches. A Global Cause, A Global Company M ajor corporations routinely support charitable causes, but it takes the dedication of individuals such as HewlettPackard’s Satjiv S. Chahil to champion particular causes, such as AIDS research. Chahil, senior vice president of global marketing for HP, has been a driving force behind HP’s generous support of amfAR at its San Francisco Fall Gala and Cinema Against AIDS Cannes benefit events. “It’s a global cause, and HP is a global company,” said Chahil. But for Chahil, personal experience lies at the root of his commitment. In the 1980s, when HIV/AIDS was “still a whisper; people weren’t saying it publicly,” a key member of Chahil’s team at a previous job “withered away because of AIDS.” amfAR Annual Report 2007 36 “We all experienced that firsthand; a whole group of contributors to our industry had been affected with that one experience,” said Chahil. “When something happens so close to you, it always has a more profound impact, and unless you are totally unfeeling, you need to do something about it.” Satjiv S. Chahil, vice As a member of an industry that relies on innovative technology, Chahil was quick to see the president of global market- value of supporting amfAR’s innovative research. His dedication to raising funds for HIV/AIDS ing for Hewlett-Packard’s research was further influenced “by the passion of the people driving the cause,” notably Sharon Personal Systems Group, Stone and Dame Elizabeth Taylor. “When the activities are done by people with so much commit- supports amfAR’s ment and sense of purpose, it inspires others to be for the cause,” he said. Giving innovative research through corporate giving. Additionally, Chahil considers it good business to support a cause that is so important to HP’s key customers, ranging from the entertainment industry to the healthcare and pharmaceutical industries. At times he has reached into his own pocket in order to bolster a particular charitable venture. Chahil believes that if you are passionate about supporting worthwhile causes, the act of corporate philanthropy becomes much more than just a business transaction. This philosophy would surely be embraced by founder Dave Packard, who 40 years ago said that simply writing a check does not end one’s responsibility to a cause. “If you do something as part of your job, it is nine to five,” said Chahil. “But if you do it as part of a cause, you never once look at the clock.” “If you do something as part of your job, it is nine to five. But if you do it as part of a cause, you never once look at the clock.” Medco Health Mediavast Medical Management Solutions, LLC Mellon Bank, N.A. Merchandise Mart Properties, Inc. Mill Management, Inc. Mission Fish Missoni USA Moda Dora Gift and Home Ltd. The Morris Foundation, Inc. The Morse Family Foundation, Inc. NARS Cosmetics, Inc. National Society of Collegiate Scholars at the University of Wisconsin– Madison NATIXIS NCH Corporation New Prospect Foundation Adina Marta Newman Fund Newmark & Company Old South Lighting OneCoast Network O’Neil Industries, Inc. Plasmanet, Inc. The Playboy Foundation Premiere Radio Networks The Louis and Harold Price Foundation The Richard and Ann J. Prouty Foundation R. Brant Design Reed Business Information Reed Family Foundation Renaissance, Inc. Richmond American Homes River Watch Restaurant, Inc. Roche Roman, Inc. The Ronson Family Philanthropic Fund Roost Rosalie and Friends, Inc. The Rosenberg Group The Norman & Constance Sadek Foundation, Inc. Sales Producers, Inc. Samsara Foundation The Sawyer Family Fund George H. Scanlon Foundation Shimoda Design Group The Susan Stein Shiva Foundation Silver Lake Technology Management, LLC Sixt GmbH & Co. Edward C. Smith Charitable Annuity Trust The M & H Sommer Foundation Sony BMG Sorenson-Pearson Family Foundation, Inc. Sotheby’s International Realty Jean L. & Robert A. Stern Foundation Studios International Swartz Family Foundation Gertrude W. and Edward M. Swartz Trust The T. Rowe Price Program for Charitable Giving T101 Limited Tailored Benefits Taryn Rose International Toyota Motor Sales, U.S.A., Inc. Universal Studios, Inc. Urban Studio LLC The Veneman Group Vera Bradley Designs, Inc. Vera Wang Bridal House, Ltd. VEST & Associates Village Capital Inc. Vincini SpA Ellen M. Violett and Mary P.R. Thomas Foundation Washington Mutual Bank We All Have AIDS Western Exhibitors, Inc. William Morris Agency Winfield Foundation The Marilyn and William Young Charitable Foundation Youngblood Ltd. Zagwear, Inc. Zarathustra Music, Inc. Anonymous (2) amfAR Annual Report 2007 Jones Apparel Group USA, Inc. Kareli Authors, Inc. Kenneth Cole Productions Foundation Kenneth Ludwig Home Furnishings, Ltd. Key Foundation Kikkerland Design Inc. Klasse Company, Inc. Kline Family Foundation Klub Services, Inc. KPFF, LLC Krause Advertising Land America Larry L. Luing Family Foundation Legend Merchant Group, Inc. Lenore Hecht Foundation, Inc. Bernard Lewis Charitable Foundation L’Oreal USA, Inc. Lucasfilm Foundation Lynn Mitchell Group, Inc. Magna Carta Foundation The Robert Mapplethorpe Foundation and Studio Mark Krueger & Associates, Inc. The May Foundation The Stephanie and Carter McClelland Foundation The Eugene McDermott Foundation John L. McHugh Foundation, Inc. 37 Giving Gess Donor Fund of the Combined Jewish Philanthropies GFI Group GiftBeat Gilbert Displays, Inc. The Gill Foundation Global Health Strategies The Joseph Gluck Foundation Gochnauer Family Foundation Moe Greendale Family Foundation, Inc. The Niki and Joe Gregory Charitable Foundation Mimi & Peter Haas Fund Hamlin Capital Management Hermes of Paris, Inc. Samuel and Hannah Holzman Trust Home Box Office Hover Family Trust The Iacocca Family Foundation ICI Worldwide, Inc. Imtech Graphics Inc. Iron Mountain Film and Sound Archives J.C. Edward Corporation Margaret G. Jacobs Charitable Trust Carl Jacobs Foundation The Nathan P. Jacobs Foundation Jeffers Design Group Jenny Hammons/Company IN-KIND CONTRIBUTIONS In-kind contributions of goods and services—either donated or discounted—are a mainstay of amfAR’s highly successful benefit events. Ranging from small cocktail parties and store openings to art auctions and international galas, these events play a critical role in raising vital funds and building AIDS awareness. amfAR relies on generous contributions by individuals and organizations of in-kind gifts ranging from design and printing of invitations and other materials, catering and beverage services, to auction and gift bag items, floral arrangements, entertainment, and more. amfAR extends grateful thanks to Kenneth Cole Productions for its many in-kind contributions, including Kenneth Cole products for meetings and conferences, and to American Airlines for the generous donations of air transportation and related services that allow the Foundation to keep travel expenses to a minimum. Since the early days of the epidemic, the art community has supported the fight against AIDS with steadfast generosity. amfAR is especially grateful to the many artists, galleries, and museums that have contributed to the resounding success of Two by Two for amfAR Annual Report 2007 38 AIDS and Art, an annual dinner and auction of works by renowned contemporary artists that benefits amfAR and the Dallas Museum of Art. Graciously hosted each year by Howard and Cindy Rachofsky, Two by Two for AIDS and Art has raised a total of $17 million for amfAR and the Dallas Museum of Art since its inception in 1999. We thank the following donors for their charitable in-kind donations. Giving ART COMMUNITY IN-KIND 303 Gallery John Adelman Ameringer & Yohe Andrea Rosen Gallery Angstrom Gallery Anthony Meier Fine Arts Anton Kern Nobuyoshi Araki Estate of Diane Arbus Architectural Arts Company Hope Atherton Barry Whistler Gallery Marc Baseman Michael Bell-Smith Bellwether Andrew Bennett William Betts bitforms Bortolami Dayan Bradly Brown Jeff Burton James Lee Byars Kristin Calabrese Ingrid Calame Scott Calhoun Douglas Leon Cartmel Justin Carun Casey Kaplan John Chamberlain Charles Cowles Gallery Cheim and Read Theresa Chong Collage 20th Century Classics Phil Collins CRG Gallery Betty Cunningham Danese Christian Dell Nick Dine Tomory Dodge Doner Studio Michele Oka Doner Donzella Dune Dunn & Brown Contemporary David Dupuis Edward Tyler Nahem Fine Art Olafur Eliasson Elizabeth Dee Gallery Derek Eller Tracey Emin Emily Eveleth Brian Fahlstrom Patrick Faulhaber Mark Ferguson Thomas Flechtner Mark Flood Florence Lynch Gallery Fort Street Studio, Brad Davis, and Janis Provisor Foxy Production Fraenkel Gallery Fredericks & Freiser Stephen Friedman Tom Friedman Friedrich Petzel Gallery Galerie Eigen + Art Galerie Karsten Greve Galerie Lelong Tim Gardner Anna Gaskell Gavin Brown’s enterprise Gerald Peters Gallery Gladstone Gallery Goff + Rosenthal Gorham Manufacturing Company April Gornik Bob Gramsma Anthony and Linda Grant Greenberg van Doren Gallery Isca Greenfield-Sanders Theresa Hackett Trenton Doyle Hancock Mark Handforth Haswellediger & Co. Gallery David Hockney Nir Hod Holly Johnson Gallery Jenny Holzer Tony Horton Hosfelt Gallery Jacqueline Humphries Pierre Huyghe Warren Isensee Jack Shainman Gallery James Cohan Gallery Bill Jensen Jewelers’ Werk Galerie John Berggruen Gallery John Connelly Presents Mado Jolain Otis Jones Josee Bienvenu Oliver Kamm Seydou Keita Ted Kincaid Per Kirkeby Knoedler & Co. David Kordansky Uwe Kowski Barney Kulok Sean Landers Ricardo Lanzarini D’Nell Larson Darryl Lauster Barry Le Va Jody Lee Nikki S. Lee Lehmann Maupin Gallery Janaki Lennie José Lerma Leslie Tonkonow Artworks + Projects Arik Levy Miranda Lichtenstein Siobhan Liddell Justin Lieberman Luhring Augustine Eva Lundsager Magen H Gallery Marco Maggi Marc Foxx Marian Goodman Gallery Marianne Boesky Gallery Marty Walker Gallery Dan McCarthy Metro Pictures Gallery Michael Werner Gallery Jason Middlebrook moniquemeloche gallery Sarah Morris Moss Ted Muehling Mulcahy Modern Nicole Klagsbrun Gallery Nic Nicosia David Noonan Adam Ogilvie Olafur Eliasson, Werkstatt & Büro Jules Olitski Tom Orr PaceWildenstein Carolanne Patterson Philip Pearlstein Adam Pendleton Emilio Perez Perry Rubenstein Gallery Danica Phelps Monica Pierce John Pomara R 20th Century Robert Rauschenberg Jim Richard Road Agent Sergio Rodrigues Susie Rosmarin Johnnie Winona Ross Michal Rovner Runyon Fine Arts, Inc. Ed Ruscha Lisa Sanditz Sara Meltzer Gallery Derrick Saunders Christoph Schmidberger David Schnell Björn Schülke Jeff Scott Sean Kelly Gallery Marco Boggio Sella Richard Serra Cindy Sherman Gary Simmons General In-Kind A Gourmet’s Pantry Aaron Barak Abigail’s Adios Golf Club Aiden Gray Alba Interiors Alberta Ferretti Alessandro Dell’Acqua Joshua Alexander, CMT American Airlines Lee and Penny Anderson Ann Gish Area San Francisco Armani Casa Arte Italica Arteriors Home Aspen Azzaro Bag, Borrow, or Steal Bailey Street Barbara Cosgrove Lamps Barneys New York Bass/Chiarello Bayonne Golf Club Beatriz Ball Beauchamp Communications Bella Rose by Chateau Bentley Dallas Berkeley Hotel Bernardaud The Biltmore Hotel Bing Bang Black Pearl bliss Dallas art patrons Cindy and Howard Rachofsky have helped raise $8.5 million for amfAR through their generous support of the charity event Two by Two for AIDS and Art, which they have hosted since 1999. I On the Cutting Edge of AIDS and Art n 1999, amfAR began teaming up with the Dallas Museum of Art for a joint fundraiser called Two by Two for AIDS and Art, an event designed to rally contemporary art lovers to raise funds for both cutting-edge HIV/AIDS research and for the museum. When hedge fund investor and art collector Howard Rachofsky and his wife, Cindy, were asked to host the event at their Richard Meier-designed home, they were happy to oblige. Nearly a decade later, the black-tie dinner and art auction has evolved into one of the city’s premier social events and amfAR’s highest-grossing domestic fundraiser, generating $8.5 million for amfAR since its inception. “We were introduced to amfAR when we were asked to host the first event in 1999,” said Cindy. “We were obviously aware of amfAR’s mission, but over time have really come to understand its critical role in the fight against AIDS.” “Maybe we thought it would be a one-time event,” remembered Howard, “but when they asked if we would be willing to do it again, well, we thought it would be fabulous. The cause is good, the plan is cogent, and it’s a wonderful opportunity.” The Rachofskys generously volunteer their efforts in coordinating Two by Two’s local leadership, assembling a roster of in-kind donors, and, above all, procuring significant contemporary artwork for auction. Infused with their energy and passion, Two by Two has evolved from a one-night fundraiser to a week of events, including an exclusive Saturday night black-tie dinner and auction, after-party, and a Sunday awards brunch where amfAR presents its Award of Excellence for Artistic Contributions to the Fight Against AIDS. “It just made sense to support amfAR, and it quickly caught on,” said Cindy. “It certainly has opened the eyes of many people in our community.” amfAR Annual Report 2007 “Over time we have really come to understand amfAR’s critical role in the fight against AIDS.” 39 Giving Allison V. Smith John Holt Smith Ken Solomon Sonnabend John Sparagana Sperone Westwater Mart Stam Steuben Glass Zoe Strauss Donald Sultan Sarah Sze Taka Ishii Gallery Tanya Bonakdar Gallery Sam Taylor-Wood Juergen Teller Ryan Trecartin and Lizzie Fitch Richard Tuttle Lane Twitchell Lesley Vance Charline Von Heyl Michael Wetzel White Cube Rachel Whiteread Christopher Williams Grant Worth Yvon Lambert New York Zach Feuer Gallery Xiaoze Zie Andrzej Zielinski Jeff Zimmerman Zwirner + Wirth David Zwirner amfAR Annual Report 2007 40 Giving BMW Bold Films Bonnie Fratis & Associates Boor Bridges Architecture Boucheron Bougainvillea Boulevard BR Guest Restaurants Bradford Renaissance Portraits Stephen Brady Brick Restaurant Romero Britto Brooklyn Style Foundation Brooks & Ian BRP Todd Buchanan Bulgari Bungalow Bungalow 8 Burj Al Arab Calvin Klein Candle Stick Carbon De Luxe Cartier SA Casa del Bianco Casa Tua DJ Cassidy Chaiken Chanel The Chef’s Table Chelsea Eye & Cosmetic Surgery Associates Chez Panisse Restaurant and Café Chopard & Cie SA Chopra Spa Christian Dior Giuseppe Cipriani Clayton Brothers Coach The Colbert Report Mary Colhoun Collections West Company C Compass Home Completely Bare Spa The Container Store Corona Décor Crabtree & Evelyn Currey Cyan Design Dallas Market Center Daniel Perry Studios Daniel Stuart Danube Restaurant The Davenport Roadhouse at The Cash Store Dean Decorize Delfina Restaurant DEMDACO Department 56 Sales, Inc. Diane Von Furstenberg Diesel The Dining Room at the Ritz-Carlton, San Francisco diPietro Todd Salon Dolce & Gabbana Domain Home Fashions Donna Karan Jason Dorn Dubai Duty Free Duran Duran Bob Egan Eileen Fisher El Raigon Argentine Asado Elie Saab Emanuel Ungaro Emirates Airlines Molly and Gregg Engles Enid Alvarez Photography and Design Etro and Echo Design Group Excalibur Facestation Michael and Barbara Faure Fendi Feraud Sarah Ferguson, Duchess of York Fine Art Lamps Fine Lines Co. Floreal, Inc. Fosters Point Four Hands Four Seasons Hotel, San Francisco Fragments Frédéric Fekkai Fresh @ Ruby Skye Frette Fusion Z Gallery Designs Holly Getty Gianfranco Ferre Gianni Versace SpA Givenchy GoGo Gear Grey Gardens Gucci Hal Boyer The Halcyon Company Rich Hamilton Hammons Hampton Pet Carriers Pamela Hanson Harry Winston Hayden Harnett Tim Headington Hedges Hen-Feathers Hermes Hewlett-Packard Company Homestead General Store Hotel (The Mercer) Hotel Bel-Air Hotel Villa d’Este Hugo Boss The Huntington Hotel and Nob Hill Spa IMAX IMG Indian Springs Resort and Spa The Institute for Culinary Education Jardinière Jean Paul Gaultier Jeanine Payer Jeffrey Atlanta New York Joanne & Company John Dellaria Salon John Kane John Varvatos Enterprises Jovovich-Hawk JP Morgan Chase Private Bank Judith Leiber Jumeirah Jane Kaplowitz Kauri Cliffs Lodge and Golf Course, Kerikeri, New Zealand Kiehl’s Since 1851 Kenneth Cole Productions Kiton Kramer Photography La Dolce Vita Ladybug Lafayette 148 New York LAFCO New York LALIQUE Landor Associates Laso Group Alberto and Consuelo Lataliste The Late Show with David Letterman Lauren Merkin L’Ermitage Leslie Street Ed Libby Tom Lieber LightenUp Designs William E. Little, Jr. Livia Dumoulin Lois Lane Travel Loloi Rugs Longchamp USA Louis Vuitton Luca Luca M∙A∙C Cosmetics Magnolia Casual Mainly Baskets Manolo Blahnik Marc Jacobs Marchesa Marco Polo Designs Mariana David McShane Mecca Men’s Youth Skincare Mexico Boutique Hotels Michael Kors MiMa by Eurofly Liza Minnelli Kylie Minogue Missoni Moët Hennessy Morgans Hotel Group Morton’s Steakhouse MTV Networks The Myriad Restaurant Group Napa Home & Garden National Golf Links of America Nautica NDI Neiman Marcus Lowell Nesbit New York Knicks Daniel Nicoletta Sarah Nix Nobu Fifty Seven Nobu Miami Beach Notre Monde NY Fitness Oakley Old World Designs Olivia Riegel Oracle Fountains Orla Kiely Orlandi Padmas Plantation Palecek Paper Rad Paul Smith Peninsula Humane Society Perilla Peter Som Pierre Olivier Deschamps Playboy Enterprises PlumpJack Postrio Pout Prada Handbag Pratesi Progress Project Runway The Rainbow Room Ralph Lauren Random Autograph Raquels Collection Brett Ratner Robert Rauschenberg Redtoenails Reinstein/Ross Hans Reiser, MD Richard Cohen, Inc. Riley James Pat Riley Rittenhouse The Ritz-Carlton, San Francisco Robert Marc Opticians Vincent A. Roberti Roberto Cavalli Rock & Republic Rodarte Rollins Jamaica Michele Rollins Sabine Römer Rob Rosenbluth and Carolyn Bernstein Rug Market Safari San Francisco Symphony Sand Castle Winery Sapa Saro Trading Company Savim USA/Fornasetti Julian Schnabel Seasonal Living Sebonic Golf Club Monica Seles Serendipity 3 Sergio Rossi Shear Bliss Sheila Kelley’s S Factor Hannah and Samuel Shipley Kimora Lee Simmons Smart Workout Smorgas Chef Restaurants Sony/BMG Music Entertainment South of France John Eric Sparacio Stella McCartney Mr. and Mrs. Spook Stream Style Paris stylicon Sunset Tower Hotel Superdeluxe TAG Mario Testino Michael Tilson Thomas Tinicum Civic Association Tivol Studios Todd Event Design Duane Tollison Tommy Toy’s Cuisine Chinoise Toss Designs Travel Planners Tres Agaves Mexican Kitchen & Tequila Lounge Trump International Golf Club TUMI Turner Sports Broadcasting Tzell Travel Until There’s A Cure Uttermost Valentino Vice Versa Victoria’s Secret Corporation Vietri Vikram Chatwal Hotels Village Divers Vintage Verandah Visual Comfort Walnut Street Theatre Gemma Ward Waterford William Wegman Janet Weiner The Weinstein Company Well Box Williams-Sonoma Home Steven Witkoff Frank Yamrus, Gregory Lind Gallery Yves Saint Laurent Zac Posen Durwood Zedd Zodax Zuni Café T A Landmark Bequest hose who knew philanthropist Ric Weiland well may not have been surprised to learn that his will included generous provisions for his favorite charitable causes. But few could have anticipated that, upon his tragic death in 2006, Weiland would leave $8 million to amfAR. The bequest will be paid out through install- ments over the course of the next eight years, providing a stable funding stream that allows amfAR to respond to emerging challenges in the HIV/ AIDS epidemic with speed and flexibility. company’s first five employees. He worked as a project leader, lead programmer, and developer for Microsoft’s BASIC and COBOL personal computing interfaces. He left Microsoft in 1988 and began to devote his energies to charitable work. Rather than start his own foundation, he chose instead to give tens of millions of dollars to various organizations. Weiland carefully reviewed the programs and finances of the charities he chose to support and resisted public acknowledgment of his generous giving. “For many years Ric Weiland was one of amfAR’s most generous and knowledgeable individual donors,” said amfAR’s CEO, Kevin Robert Frost. “His dedication and commitment to our work in ending the global AIDS epidemic was an inspiration to us all.” Weiland died in June 2006 at the age of 53, after a long battle with depression. The bulk of his estate went to establish the Weiland Designated Philanthropist Ric Weiland—one of Microsoft’s first five employees— bequeathed $65 million to national gay rights and HIV/AIDS organizations, including $8 million to amfAR. Fund, to be managed by the Seattle-based Pride Foundation, with $65 million allocated to a group of national gay rights and HIV/AIDS organizations. “Ric wanted to be sure that his contributions would be used effectively and efficiently to help improve and extend lives—in amfAR’s case, the lives of people living with HIV/AIDS,” said Frost. “As a donor to amfAR, Ric gave both with his head and with his heart.” “Ric wanted to be sure that his contributions would be used effectively and efficiently to help improve and extend lives—in amfAR’s case, the lives of people living with HIV/AIDS.” 41 Giving 1975—the year they founded Microsoft—and became one of the software amfAR Annual Report 2007 Weiland joined his high school classmates Bill Gates and Paul Allen in PLANNED GIVING Planned, or deferred, giving is a farsighted investment in the future. Generous bequests and other planned gifts help ensure that amfAR can sustain its support of innovative HIV/AIDS research programs over the long term. Between October 2006 and September 2007, the Foundation was the grateful beneficiary of the planned gifts listed below, including particularly generous legacies from Gertrude Horowitz, Marie Eliopoulos, Martin F. and Irene R. Murphy, and Lorraine E. Cantor. amfAR received gifts from the estates of amfAR Annual Report 2007 42 Maureen E. Bacchi Michael F. Bennett Mary G. Brakefield Mildred Burg Lorraine E. Cantor Herbert Chiltern Gladys Chinn Marilyn Joyce Colbert Frances M. Corrao Susan Ethel Cox Aileen Cramer John Perryman Davidson, III Wilfred W. and Ruth J. Davies Claire E. Dick Jean Eastman Marie Eliopoulos Lillian and Frank Fields Jill & Jayne D. Franklin Edith Hollander Goldberg Frank L. Gulizia Gertrude Horowitz Bertha M. Jacobson Steven D. Kaeser Gertrude Kartzmer Andrew Kott Olive M. Laubenthal Michael Le Clair Robert C. Lees Jerome H. Lever Ralph A. Ludlow David Edward MacArthur Galeb H. Maher Francisco Martin Donna M. Mellem Dorothy Merdian Michael Metzger Alice Ruth Meyer Margaret W. Midgett Joan Mills Miller May M. Moore Marice Murphy Martin F. & Irene R. Murphy Jannette Powell James Michael Rampe Peter P. Rossi Roberta Schecter Winifred E. Shaheen Joseph L. K. Snyder Freda Sobel Robert C. Tesch James Gordon Umberger Richard W. Weiland Thelma and Clyde West Roy Glenn Wood VOLUNTEER SUPPORT Giving amfAR’s Board of Trustees, Program Board, and Scientific Advisory Committee are composed entirely of individuals who generously volunteer their time, professional expertise, and financial resources to the Foundation’s benefit. These core volunteers span a range of backgrounds and areas of expertise and include scientists, physicians, academics, and business leaders. In some locales, notably Dallas, Philadelphia/Bucks County, and San Francisco, committed individuals have established volunteer steering committees and have organized benefit events that help attract new supporters and build awareness of amfAR’s work. In addition, amfAR is fortunate to enjoy the support of many celebrities from the fields of art, fashion, film, music, haute cuisine, publishing, and television who generously donate their time and talents to the Foundation’s benefit events. amfAR is especially grateful for the dedicated support of its founding international chairman, Dame Elizabeth Taylor, and Sharon Stone, global fundraising chairman, who remain highly visible and effective spokeswomen for the Foundation. For many years, amfAR has benefited enormously from the steadfast support of three unique volunteer organizations: Concerned Parents for AIDS Research (CPFA) was created in 1989 by a group of parents who, spurred by Alison Gertz’s public revelation that she had AIDS, realized that young people everywhere were at risk. CPFA seeks to secure an AIDS-free future by funding basic biomedical and clinical research to develop a preventive vaccine and a cure for HIV/AIDS, and by working to raise AIDS awareness and encouraging parents to become actively involved in finding a solution to this public health crisis. Since its inception, CPFA has raised $4 million for AIDS research. Gift for Life (GFL) is a nationwide group of volunteers from the gift, stationery, tabletop, and decorative accessories industries who raise funds for AIDS research and build awareness among friends and colleagues. Founded in 1992, GFL has generated more than $4 million in support of amfAR’s programs. The Bucks County Committee is part of the Greater Philadelphia community, which was among the first to respond to the AIDS crisis in this country. To date, these donors have contributed more than $4.5 million to amfAR, which the Foundation has used to GFL Board of Directors Arun Agarwaal John Amiri Tabitha Bowling Sheila Charton Mary Liz Curtin Cole Daugherty Sharon Davis Mike Dean Debra Gold Lisa Goodman Jenny Hammons Su Hilty Kathy Krassner Terence Morris David Moses Michael Ruddell Jill Sands John Saxtan Peter Schauben Gerry Seibel Warren Shoulberg Cathy Steel Paul Thompson Laura Van Zeyl Joyce Washnik Nancy Wolkow Bucks County Committee Randy Apgar Scott Bass Allen Black Bob Egan Sally and Richard Henriques Greg Kammerer David Lewis Jim McClelland David McShane Lynn Miller Doug and Betsy Rendall Renny Reynolds Kenneth G. Schaefer Sam and Happy Shipley Jack Staub David Topel Fred White Celebrity Volunteers Casey Affleck Ted Allen Woody Allen and Soon-Yi Previn Kevin Bacon Ellen Barkin Mischa Barton Naomi Campbell Tracy Chapman Don Cheadle George Clooney Sofia Coppola Matt Damon Rosario Dawson Harold Dieterle Thom Filicia Andy Garcia Richard Gere Whoopi Goldberg Elliott Gould Greg Grunberg Tim Gunn Jerry Hall Marcia Gay Harden Goldie Hawn Paris Hilton Dennis and Victoria Duffy Hopper Elizabeth Hurley Cheyenne Jackson Sir Elton John and David Furnish Eve Jeffers Milla Jovovich Nicole Kidman Beyoncé Knowles Julian Lennon Carey Lowell Diego Luna Elle Macpherson Sophie Marceau Jesse L. Martin Jack McBrayer Rose McGowan Eva Mendes Liza Minnelli Kylie Minogue Liam Neeson Petra Nemcova Cynthia Nixon Rosie O’Donnell Orfeh Aishwarya Rai Anthony Rapp Brett Ratner Natasha Richardson Robert Rodriguez Kurt Russell Claudia Schiffer Julian Schnabel Kyra Sedgwick Chloë Sevigny Garry Shandling Liz Smith Kevin Spacey Barbra Streisand Sharon Stone Dame Elizabeth Taylor Tracie Thoms Stanley Tucci Dita Von Teese Gemma Ward Kerry Washington Sigourney Weaver Harvey Weinstein Robin Williams Michelle Yeoh WORKPLACE GIVING Workplace giving programs allow donors to direct a percentage of each paycheck or a fixed dollar amount to amfAR. Among the many generous individuals who contribute in this way are federal employees and U.S. military personnel who make donations through the Combined Federal Campaign (CFC). amfAR is listed with the CFC as AIDS Research Foundation (amfAR), and our CFC designation number is 11996. amfAR is represented in the CFC by Community Health Charities, a federation of national health agencies. Other donors make their contributions through state and municipal employee campaigns, United Way “write-in” designations, and independent corporate workplace giving programs. amfAR is deeply grateful to the companies and agencies that allow it to participate in their campaigns and to the many individuals who direct their workplace contributions to the fight against AIDS. 43 Giving CPFA Executive Board of Directors Andrea Acker Roberta Bogen Ivy Duneier Marjorie Emden Carol Gertz Annie Gilbert Rosalind Glaser Dr. Andrew Lipschitz Eileen Mitzman Lois Nipon Tina Simner Rory Teitelbaum Wendy Wetchler amfAR Annual Report 2007 provide grants and fellowships to 80 Philadelphia-area researchers. FINAN C IA L S U MMAR Y FROM THE TREASURER AND THE CHAIR OF THE FINANCE AND BUDGET COMMITTEE The fiscal year ending September 30, 2007, was a period of solid growth and financial stability for amfAR, The Foundation for AIDS Research, and we are pleased to present a summary of the audited financial statements from this period. The Foundation was able to exceed its ambitious fundraising goal, generating a total of $23.8 million in public support and revenue—a 30 percent increase over the previous year. A low supporting services ratio—the ratio of fundraising and management expenses to total support and revenue—of 18.5 percent demonstrated a high degree of operating efficiency. Another key fiscal indicator, the program spending ratio, came in at a robust 76.9 percent—meaning that 76.9 cents out of every dollar spent was invested directly in vital program activities. The Foundation ended the year with an operating surplus of $4.8 million. This was largely the result of a resoundingly successful benefit events season, which generated an unanticipated 47 percent increase in revenues over the previous year. amfAR Annual Report 2007 That funding surplus allowed amfAR the flexibility to move quickly in establishing two important new initiatives. The Mathilde Krim Fellowships in Basic Biomedical Research provide a much-needed funding stream for bright young scientists seeking innovative solutions to HIV/AIDS. And the MSM Initiative seeks to address and reverse the alarmingly high rates of HIV infection among men who have sex with men (MSM) in resource-limited countries. Moving from concept to funding in less than a year, amfAR was able to scale up these programs on short notice, and announced initial grants for both just a few months after the close of the fiscal year. 44 In 2007, amfAR again met the stringent requirements of governance and financial accountability demanded by the Better Business Bureau’s Wise Giving Alliance and the federal government’s workplace fundraising program, the Combined Federal Campaign, as well as many state employee workplace giving campaigns. Financial Summary A copy of the complete audited financial statements, prepared in accordance with generally accepted accounting principles for not-for-profit organizations as established by the American Institute of Certified Public Accountants, is available upon request from amfAR at 120 Wall Street, 13th Floor, New York, NY 10005, and can be accessed online at www.amfar.org. Wallace Sheft, C.P.A. Michael J. Klingensmith Treasurer Chair, Finance and Budget Committee Public Support and Revenue Investment income and other revenue: Expenses Management and general: 8.9% 3.5% Government funding: 17.3% Fundraising: 14.2% Contributions 79.2% Program Services 76.9% 45 Financial Summary Total expenses $18,998,904 Change in net assets 4,797,520 Net assets, beginning of year 15,168,021 Net assets, end of year $19,965,541 STATEMENT OF FINANCIAL POSITION Assets Cash and investments $21,631,048 Pledges and receivables, net 1,624,941 Prepaid expenses and other assets 453,871 Merchandise inventory and donated assets 513,869 Furniture, equipment, and leasehold improvements, net 840,517 Total assets $25,064,246 Liabilities Accounts payable and accrued expenses $1,267,408 Grants and fellowships payable, net 1,835,159 Deferred support and refundable advances 1,429,967 Other long-term liabilities 566,171 Total liabilities $5,098,705 Net assets Unrestricted $14,848,535 Temporarily restricted 4,815,046 Permanently restricted 301,960 Total net assets $19,965,541 Total liabilities and net assets $25,064,246 amfAR Annual Report 2007 STATEMENT OF ACTIVITIES AND CHANGES IN NET ASSETS For the year ended September 30, 2007 Public Support and Revenue Public support $7,155,947 Special events 9,741,974 Planned giving 1,947,199 Government funding 4,105,703 Investment income and other revenue 845,601 Total public support and revenue $23,796,424 Expenses Research $7,577,791 Global initiatives 2,585,001 Public policy 1,081,867 Education and information 3,366,625 Total program services $14,611,284 Fundraising $2,691,494 Management and general 1,696,126 Total supporting services $4,387,620 For complete audited financial statements, visit www.amfar.org L e a d e r s h i p Board of Trustees 2007 Chairman of the Board Kenneth Cole Chairman and Chief Executive Officer Kenneth Cole Productions New York, NY amfAR Annual Report 2007 46 Vice Chairman Patricia J. Matson Senior Vice President, Communications (emerita) ABC, Inc. New York, NY Vice Chairman John C. Simons Managing Partner Corporate Fuel Partners, LLC New York, NY Leadership and Advisory Committees Treasurer Wallace Sheft, C.P.A. Partner Sheft & Co. Westbury, NY Secretary William D. Zabel, Esq. Senior Partner Schulte Roth & Zabel, LLP New York, NY Founding International Chairman Dame Elizabeth Taylor, D.B.E. Actress Bel Air, CA Founding Chairman Mathilde Krim, Ph.D. Adjunct Professor Mailman School of Public Health Columbia University New York, NY a n d Adv i s o r y TRUSTEES Arlen H. Andelson Andelson Properties Los Angeles, CA Harry Belafonte President Belafonte Enterprises, Inc. New York, NY David Bohnett Chairman David Bohnett Foundation Beverly Hills, CA Zev Braun President and Chief Executive Officer Braun Entertainment Group, Inc. Beverly Hills, CA Jonathan S. Canno New York, NY Donald A. Capoccia Managing Principal and Founder BFC Partners New York, NY Jane Breckenridge Eisner President The Eisner Foundation Bel Air, CA Arnold W. Klein, M.D. Professor of Medicine/Dermatology University of California, Los Angeles Beverly Hills, CA c o m m i t t e e s Edward L. Milstein Co-Chairman Milstein Brothers Capital Partners New York, NY Natasha Richardson Actress New York, NY Mario Stevenson, Ph.D. Director, Center for AIDS Research Professor, Program in Molecular Medicine University of Massachusetts Medical School Worcester, MA Vincent A. Roberti Chairman and Chief Executive Officer Palisades Media Corporation New York, NY HONORARY TRUSTEES Allan Rosenfield, M.D. Dean and DeLamar Professor of Public Health Mailman School of Public Health Columbia University New York, NY John F. Breglio, Esq. Paul, Weiss, Rifkind, Wharton & Garrison New York, NY Alan D. Schwartz President The Bear, Stearns Companies, Inc. New York, NY Mouna E. Ayoub Paris, France Robert L. Burkett The Carmen Group Washington, D.C. Michael Fuchs New York, NY Diana L. Taylor Managing Director Wolfensohn & Co. New York, NY Sandra Hernández, M.D. Chief Executive Officer The San Francisco Foundation San Francisco, CA Kevin Wendle Entrepreneur New York, NY; Paris, France Sherry Lansing Chief Executive Officer/Founder The Sherry Lansing Foundation Los Angeles, CA ADJUNCT TRUSTEES Jane F. Nathanson Psychologist Chair, Jane and Marc Nathanson Community Foundation Los Angeles, CA Michael J. Klingensmith Executive Vice President Time Inc. New York, NY David E. Bloom, Ph.D. Chair, Department of Population and International Health Harvard School of Public Health Boston, MA Michele V. McNeill, Pharm.D. Chairman McNeill Family Foundation Long Boat Key, FL R. Martin Chavez, Ph.D. Partner Goldman, Sachs & Co. New York, NY Richard H. Metzner Principal Metzner-Schneider Associates Dallas, TX Mervyn F. Silverman, M.D., M.P.H. President Mervyn F. Silverman Associates, Inc. Crockett, CA The Rev. Dr. Randolph Nugent General Secretary (ret.) General Board of Global Ministries United Methodist Church New York, NY Pauline Phillips Nationally Syndicated Columnist (ret.) Los Angeles, CA Joel D. Weisman, D.O. Physician Rancho Mirage, CA Chair, Public Policy Committee David E. Bloom, Ph.D. Chair, Dept. of Population and International Health Harvard School of Public Health Boston, MA IN MEMORIAM Sheldon W. Andelson, Esq. Mrs. Albert D. Lasker Jonathan M. Mann, M.D., M.P.H. Maxine Mesinger Peter Scott, Esq. Tom Stoddard Global Fundraising Chairman Sharon Stone amfAR AMBASSADORS Milla Jovovich Liza Minnelli Michelle Yeoh Program Board Chair Allan Rosenfield, M.D. Dean and DeLamar Professor of Public Health Mailman School of Public Health Columbia University New York, NY Chair, Global Initiatives Committee Mervyn F. Silverman, M.D., M.P.H. President Mervyn F. Silverman Associates, Inc. Crockett, CA Vice Chair, Public Policy Committee Margaret (Peggy) Hamburg, M.D. Vice President for Biological Programs Nuclear Threat Initiative Washington, D.C. Chair, Research Committee Mario Stevenson, Ph.D. Director, Center for AIDS Research Professor, Program in Molecular Medicine University of Massachusetts Medical School Worcester, MA Vice Chair, Research Committee Sherry Deren, Ph.D. Director Institute for AIDS Research Center for Drug Use and HIV Research National Development and Research Institutes, Inc. New York, NY Mathilde Krim, Ph.D., ex officio Adjunct Professor Mailman School of Public Health Columbia University New York, NY members Dawn Averitt Bridge Founder The Well Project Nellysford, VA Tim Brown, Ph.D. Senior Fellow, Population and Health Studies East-West Center Honolulu, HI Alex Carballo-Diéguez, Ph.D. Associate Professor and Research Scientist HIV Center for Clinical & Behavioral Studies New York State Psychiatric Institute New York, NY Willard (Ward) Cates, Jr., M.D., M.P.H. President, Research Family Health International Durham, NC R. Alta Charo, J.D. Warren P. Knowles Professor of Law & Bioethics University of Wisconsin Law School Madison, WI Grant N. Colfax, M.D. Director of HIV Prevention and Research San Francisco Department of Public Health San Francisco, CA Hoosen (Jerry) Coovadia, M.D. Victor Daitz Professor of HIV/AIDS Research Doris Duke Medical Research Institute Nelson Mandela School of Medicine University of KwaZulu Natal Congella South Africa Carl W. Dieffenbach, Ph.D. Director, Basic Sciences Program Division of AIDS, NIAID Bethesda, MD Wafaa El-Sadr, M.D., M.P.H. Chief, Division of Infectious Diseases Harlem Hospital Center Professor of Clinical Medicine and Epidemiology Columbia University New York, NY Sherry Glied, Ph.D. Professor and Chair Department of Health Policy and Management Mailman School of Public Health Columbia University New York, NY Jennifer Kates, M.A., M.P.A. Vice President and Director, HIV Policy Kaiser Family Foundation Washington, D.C. Patrick Chung-ki Li, M.B.B.S. Chief of Service Department of Medicine Queen Elizabeth Hospital Hong Kong SAR, China Kenneth H. Mayer, M.D. Professor of Medicine and Community Health Brown University/The Miriam Hospital Providence, RI William E. Paul, M.D. Chief, Laboratory of Immunology National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Bethesda, MD Peter R. Staley Founder & Editor AIDSmeds.com Brooklyn, NY David Vlahov, Ph.D. Director Center for Urban Epidemiological Studies New York Academy of Medicine New York, NY amfAR Annual Report 2007 Michael D. Shriver Co-Director, AIDS Policy Research Center AIDS Research Institute University of California, San Francisco San Francisco, CA Vice Chair, Global Initiatives Committee Adeeba Kamarulzaman, M.B.B.S., F.R.A.C.P. Professor Head of Infectious Diseases Unit Department of Medicine University of Malaya Kuala Lumpur Malaysia 47 Leadership and Advisory Committees Leonard Rabinowitz President Studio CL Los Angeles, CA BOARD COMMITTEES Executive Committee Kenneth Cole, Chair Donald A. Capoccia Michael J. Klingensmith Mathilde Krim, Ph.D. Patricia J. Matson Wallace Sheft, CPA John C. Simons Allan Rosenfield, M.D. William D. Zabel, Esq. Audit Committee Wallace Sheft, CPA, Chair R. Martin Chavez, Ph.D. John C. Simons amfAR Annual Report 2007 48 Board Development Committee William D. Zabel, Esq., Chair Zev Braun Jane B. Eisner Arnold W. Klein, M.D. Mathilde Krim, Ph.D. Patricia J. Matson Alan Schwartz Compensation & Organizational Development Committee John C. Simons, Chair Michael J. Klingensmith Richard H. Metzner Leadership and Advisory Committees Finance & Budget Committee Michael J. Klingensmith, Chair Vincent A. Roberti John C. Simons Fund Development Committee Donald A. Capoccia, Chair Jonathan S. Canno Edward L. Milstein Vincent A. Roberti William D. Zabel, Esq. Scientific advisory committee Mario Stevenson, Ph.D., Chair Sherry Deren, Ph.D., Vice Chair Rafi Ahmed, Ph.D. Angela Aidala, Ph.D. Jonathan S. Allan, D.V.M. Katheryn Anastos, M.D. Deborah Anderson, Ph.D. Warren A. Andiman, M.D. Peter S. Arno, Ph.D. Julia Arnsten, M.D., M.P.H. Larry O. Arthur, Ph.D. Marcel A. Baluda, Ph.D. Robert B. Belshe, M.D. Samuel A. Bozzette, M.D., Ph.D. Jason Brenchly, Ph.D. Dennis R. Burton, Ph.D. Salvatore T. Butera, D.V.M., Ph.D. Alex Carballo-Dieguez, Ph.D. David D. Celentano, Sc.D., M.H.S. Sarah H. Cheeseman, M.D. David B. Clifford, M.D. C. Budd Colby, Ph.D. Grant Colfax, M.D. Deborah Jean Cotton, M.D., M.P.H. Bryan Richard Cullen, Ph.D. Susanna Cunningham-Rundles, Ph.D. Richard Thomas D’Aquila, M.D. John Delos DeLamater, Ph.D. Roger Detels, M.D., M.S. Carl W. Dieffenbach, Ph.D. Daniel C. Douek, M.D., Ph.D. D. Peter Drotman, M.D., M.P.H. Frank Duff, M.D. Anke A. Ehrhardt, Ph.D. Homayoon Farzadegan, Ph.D. Dianne M. Finkelstein, Ph.D. Jacquelyn H. Flaskerud, Ph.D. Gerald Herbert Friedland, M.D. Richard Brian Gaynor, M.D. Howard E. Gendelman, M.D. Peter Ghazal, Ph.D Marya Gwadz, Ph.D. Nancy L. Haigwood, Ph.D. Dean Hamer, Ph.D. Polly Harrison, Ph.D. Sharon Hillier, Ph.D. Charles H. Hinkin, Ph.D. Martin S. Hirsch, M.D. David Ho, M.D. Gary Norman Holland, M.D. Thomas J. Hope, Ph.D. Shiu-Lok Hu, Ph.D. John Hylton, M.H.S., Ph.D. David E. Kanouse, Ph.D. Ronald C. Kennedy, Ph.D. Vineet KewalRamani, Ph.D. Robert Stephen Klein, M.D. Richard Kornbluth, M.D., Ph.D. Richard A. Koup, M.D. Joan Kreiss, M.D., M.S.P.H. Nathaniel R. Landau, Ph.D. Alan L. Landay, Ph.D. Amy Lansky, Ph.D. Jeffrey Laurence, M.D. Michael Lederman, M.D. Tun-Hou Lee, D.Sc. Michael J. Leibowitz, M.D., Ph.D. Carol Levine, M.A. Robert J. Levine, M.D. Judy Lieberman, M.D., Ph.D. H. Kim Lyerly, M.D. David M. Margolis, M.D. Martin H. Markowitz, M.D. Marta L. Marthas, Ph.D. Kenneth Hugh Mayer, M.D. Justin C. McArthur, M.B.B.S., M.P.H. Joseph M. McCune, M.D., Ph.D. Ian McGowan, M.D., Ph.D. Michael S. McGrath, M.D., Ph.D. A.D McNaghten, Ph.D. John Gordon McNeil, M.D., M.P.H. Peter Messeri, Ph.D. Donna Mildvan, M.D. Christopher Murrill, Ph.D., M.P.H. Jay A. Nelson, Ph.D. Valerie Len Ng, Ph.D., M.D. Nancy Padian, M.P.H., Ph.D. Savita Pahwa, M.D. Tristram G. Parslow, M.D., Ph.D. Jeremy Paul, Ph.D. Matija Peterlin, M.D. Anthony John Pinching, F.R.C.P., D.Phil William G. Powderly, M.D., F.R.A.C.P. Lynn Pulliam, Ph.D. Lee Ratner, M.D., Ph.D. Andrew Rice, Ph.D. Melissa Robbiani, Ph.D. Yvonne J. Rosenberg, Ph.D. Ruth M. Ruprecht, M.D., Ph.D. Travis Sanchez, D.V.M. Frederick A. Schmitt, Ph.D. Gerald Schochetman, Ph.D. Robert Turner Schooley, M.D. Ola A. Selnes, Ph.D. Ganes C. Sen, Ph.D. Frederick P. Siegal, M.D. Gail Skowron, M.D. Whaijen Soo, M.D., Ph.D. James L. Sorensen, Ph.D. Leonidas Stamatatos, Ph.D. Simon Swingler, Ph.D. Edward Elliot Telzak, M.D. Ernest F. Terwilliger, Ph.D. Gwen Van Servellen, R.N., Ph.D. Barbara Visscher, M.D., Dr.P.H. David Vlahov, Ph.D. David J. Volsky, Ph.D. Bruce D. Walker, M.D. J. Brice Weinberg, M.D. Darrell P. Wheeler, Ph.D., M.P.H. Steven S. Witkin, Ph.D. Peter R. Wolfe, M.D. Richard T. Wyatt, Ph.D. Management group Kevin Robert Frost Chief Executive Officer Susan J. Blumenthal, M.D., M.P.A. Senior Policy and Medical Advisor Deborah C. Hernan Assistant Treasurer and Vice President, Public Information Rowena Johnston, Ph.D. Vice President, Research Jeffrey Laurence, M.D. Senior Scientific Consultant John F. Logan, Esq. Assistant Secretary, Vice President, and General Counsel Bill Melamed Vice President, Development Scott Newman, M.B.A. Assistant Treasurer and Vice President, Finance and Administration Monica S. Ruiz, Ph.D., M.P.H. Acting Director, Public Policy A C K NO W LEDGMEN T S amfAR extends its grateful appreciation to William H. Byer, Variable Graphics LLC, for partial donation of the printing of this Annual Report. PHOTO CREDITS Page 2 Eric T. Michelson Page 3 Lawrence Switzer Page 6 Courtesy of Dr. Carolina Herrera; Piotr Bizior/SXC Page 7 Courtesy of Dr. Fong Siew Moy; Lawrence Switzer Page 8 © Les Cunliffe/Dreamstime.com Page 10 Jeff Vespa/WireImage Page 11 Courtesy of Dr. Ya-Lin Chiu Page 12 Courtesy of Dr. Robin Shattock Page 15 © Zol/Dreamstime.com Page 16 Sam Avrett Page 17 Courtesy of Dr. Pope Kosalaraksa Page 19 Karl Grobl Page 22 © Mike Rogal/Dreamstime.com; © Diadem Images/Dreamstime.com Page 24 Lawrence Switzer Page 25 Emily Byram Page 26 © Dmitriy Shironosov/Dreamstime.com Page 28 Courtesy of Dr. Peter Shalit Page 29 Kenneth Cole Productions Page 33 Dr. Rowena Johnston Page 36 Courtesy of Hewlett-Packard Page 39 Bruno amfAR, The Foundation for AIDS Research, is a New York State not-for-profit corporation and is exempt from federal income tax under Section 501(c)(3) of the United States Internal Revenue Code (“the code”) and corresponding New York Revenue and Taxation Code sections. Contributions to amfAR are tax-deductible in accordance with the code. amfAR meets the BBB Page 41 Courtesy of Stanford University Archives This Annual Report was produced by amfAR’s Public Information department: Andrew McInnes, Group Director, Public Information Raoul Norman, Creative Director Constance Herndon, Senior Staff Writer Carolyn Hanson, Staff Writer Winnie McCroy, Staff Writer Barbara Battle, Editorial Manager Yolande Hunter, Production Artist Natalie Jacobs, Assistant Coordinator Wise Giving Alliance’s Standards for Charity Accountability. AMERICAN AIRLINES is the official airline of amfAR. 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