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V O L U M E TEN I S S U E THREE THE HEART OF THE MATTER SPRING FALL2009 2009 A newsletter from the California Heart Center Foundation Studies Affirm Value of Healthy Lifestyle by Ed Edelson, HealthDay Reporter Those who ate right, exercised lowered chances of cardiovascular trouble All that heart-healthy advice about eating the right foods, exercising and losing weight pay off in real life for both men and women, two new studies show. The reports, both originating at Brigham and Women's Hospital in Boston and published in the July 22/29 issue of the Journal of the American Medical Association, focused on different aspects of cardiovascular risk in two large groups: the 83,882 women in the second Nurses' Health Study, and the 20,900 men in the Physicians' Health Study I. Both arrived at the same conclusion: Do the right things, and you get measurable benefits. Simultaneous appearance of the two reports was more or less a coincidence, said Dr. Luc Djousse, an associate epidemiologist at Brigham and Women's at Harvard Medical School, who led the men's study. The study in men looked at the relationship between the lifetime risk of heart failure and six lifestyle factors: obesity, exercise, smoking, alcohol intake, consumption of breakfast cereals, and consumption of fruits and vegetables. "Previous studies have shown benefit from individual lifestyle factors," Djousse said. "We looked at all of these factors together." That look found a straight-line relationship between adherence to healthy lifestyle factors and the risk of heart failure, the progressive loss of ability to pump blood that is often a prelude to death. The lifetime risk of heart failure in the 22-year study was about one in five in men who ignored the advice about all beneficial lifestyle factors and one in 10 for those who adhered to four or more of the factors. "The one with a huge difference was adiposity," Djousse said. "The risk of heart failure was 17 percent in men who were overweight or obese, and about 11 percent in those of normal weight." Exercise was the next most important. Heart failure occurred in 11 percent of the men who exercised five or more times a week and in 14 percent of those who did not exercise, Djousse said. Smoking played a surprisingly small role, probably because its incidence was not high among the participants. "These were all physicians, so you would expect a smaller amount of smoking," Djousse said. The women's study looked at the association between high blood pressure -- a significant risk factor for heart disease, stroke and other cardiovascular problems -- and six lifestyle factors: obesity, exercise, alcohol intake, use of non-narcotic painkillers, adherence to a diet designed to prevent high blood pressure and intake of supplemental folic acid. All six were found to be associated with the risk of developing high blood pressure in the 14-year study, and the association was cumulative. Women who followed advice on all six factors -just 0.3 percent of those in the group -- had an 80 percent lower incidence of high blood pressure than those who followed none of the rules. The incidence was 72 percent lower for the 0.8 percent of the women who followed five lifestyle rules, 58 percent lower for the 1.6 percent of the women following four rules and 53 percent lower for the 3.1 percent of the women who followed I N T HIS I SSUE : PAGE ONE: RESEARCH NEWS: Studies Affirm Value of Healthy Lifetyle PAGE TWO: Team Up For Better Health PAGE FOUR: Community Shows Support for 5K Event three rules. As in the male group, obesity was the most important risk factor. While the clear message of both studies is that "a healthy lifestyle prevents a number of illnesses," what is often overlooked is that the choice of a healthy lifestyle is not a purely individual decision, said Dr. Veronique L. Roger, a professor of medicine and epidemiology at the Mayo Clinic, who wrote an accompanying editorial. "There is a shared responsibility between the individual and the community," said Roger, who read off a dictionary definition of lifestyle as "a typical way of life of an individual, group or culture." "The reality is that society has engineered physical activity out of our lives," Roger said. "And it is difficult for me to tell someone in Nebraska to follow the Mediterranean diet, which is anchored in the culture of that society." Government interventions, such as the decision of New York and other communities, to bar smoking in restaurants and bars, can help more people achieve the healthy lifestyles described in the two reports, she said. SOURCES: Luc Djousse, M.D., Sc.D, associate epidemiologist, Brigham and Women's Hospital, and associate professor, medicine, Harvard Medical School, Boston; Veronique L. Roger, M.D., professor, medicine, Mayo Clinic, Rochester, Minn.; July 22/29, 2009, Journal of the American Medical Association Copyright © 2009 ScoutNews, LLC. All rights reserved. Reprinted with permission. Questions or comments can be directed to: California Heart Center Foundation (310) 825-8900 phone (310) 267-0019 fax WWW.CALIFORNIAHEARTCENTER.ORG Team Up for Better Health Want more protection against skin cancer? Drink coffee before a workout. Trying to build muscle? Stretch between sets. Hoping to reduce your risk of stroke? Squeeze a little lemon into your green tea. Though seemingly random, these unusual combinations highlight the latest findings from the emerging practice that we call "synergistic medicine," which pairs health-boosting strategies from fields as divergent as kinesiology, neuroscience, and dermatology-with truly outstanding results. We have rounded up the best dynamic duos for knocking out memory loss, fatigue, disease, weight gain, and more. Talk about power couples! 1. Protect Your Heart: Green Tea + Lemon In a study of more than 40,500 Japanese men and women, those who drank five or more cups of green tea every day had the lowest risk of dying of heart disease and stroke. Researchers attribute the protective effect to catechins, powerful antioxidants. Trouble is, less than 20% of these relatively unstable compounds survive digestion. To get more out of every cup, squeeze in some lemon juice. The vitamin C in lemons helps your body absorb 13 times more catechins than it can obtain from plain tea alone, according to a Purdue University study. Sip to your heart's content: With the catechin boost from vitamin C, you can help your heart by drinking just one or two cups daily. If lemons make you pucker, squeeze in some orange, lime, or grapefruit juice; they increase antioxidant absorption, too, though to a lesser extent. Just skip the milk-it actually interferes with absorption--and stick to freshly brewed tea, hot or iced. The catechins in ready-to-drink bottles are ineffective. 2. Boost Brainpower: Exercise + Music Twenty-one minutes of exercise is all it took to lift the moods of cardiac rehabilitation patients in an Ohio State University pilot study. But when participants listened to Antonio Vivaldi's Four Seasons on headphones, they performed significantly better on a verbal fluency test afterward. Researchers believe exercise boosts cognitive performance by stimulating the central nervous system, and the addition of music may help organize thoughts. Move and groove: Though researchers haven't explored whether these findings can be generalized to apply to healthy adults, it can't hurt to exercise with your MP3 player. Stick to the same routine the study participants followed--gradually increase the slope and speed on your treadmill every 10 minutes until you can speak only in short sentences (walk for a minimum of 21 minutes). And listen to the music of your choice; any genre should work just as effectively as classical. 3. Rev Immunity: Pot Roast + Carrots This popular comfort food makes you feel good for a reason. Carrots are chock-full of vitamin A, a retinol that plays a key role in preventing and fighting off infections. But without the zinc in the beef, your body wouldn't be able to use it. Vitamin A can travel through the blood only when it's bound to a protein. "And zinc is required to make that retinol-binding protein," says Roberta L. Duyff, RD, author of American Dietetic Association Complete Food and Nutrition Guide. "So if you don't have enough zinc, vitamin A is not going to move from the liver to the tissues, where it does its job." Germ-fighting combos: Dark orange, yellow, red, and green fruits and vegetables are good sources of vitamin A. For a little lighter fare, pair them with zinc-rich proteins: Slice fresh mango into lowfat yogurt, eat a small sweet potato with your fish, or stuff your chicken with spinach, Florentine-style. 4. Flush Fat: Burger + Frozen Yogurt The next time you eat a food high in saturated fat, follow it with a low-fat, calcium-rich dessert. Calcium binds to fatty acids in the digestive tract, blocking their absorption. In one study, participants who ate 1,735 mg of calcium from low-fat dairy products (about as much as in five 8-ounce glasses of fat-free milk) blocked the equivalent of 85 calories a day. Beef up calcium: Researchers haven't determined exactly how much calcium you should consume with each high-fat meal, says Cynthia Heiss, PhD, RD. "But by including a glass of fat-free or soy milk or a fortified juice with a fatty meal, you may get a boost if you're trying to lose weight," she says. 5. Ward Off Heart Disease: PLAC test + HSCRP test These tests measure Lp-PLA2 and CRP levels, two important markers of the kind of inflammation caused by the accumulation of plaque in your arteries--a big predictor of heart disease. When doctors added the results of these screenings to their usual assessment of risk factors (blood pressure, cholesterol, etc.), they ended up reclassifying 39% of intermediate-risk patients-including 11% who were in need of more serious treatment-reports a new study published in the journal Stroke. Many of these patients may now be candidates for statins. Get the tests if: You're middle-aged and your cholesterol is normal but you smoke, have gained weight, have a family history of heart disease, or have borderline hypertension, says Christie M. Ballantyne, MD, study coauthor and director of the Center for Cardiovascular Disease Prevention at Methodist DeBakey Heart and Vascular Center in Houston. If you do get put into a higher-risk category, statins aren't the only treatment. Lp-PLA2 and CRP levels both respond well to diet and exercise. 6. Save Your Eyesight: Salad + Avocado Spinach may be good for your eyes, but avocado makes it even more effective. Researchers at The Ohio State University found that when adults ate a lettuce, spinach, and carrot salad with or without 3 tablespoons of avocado, the avocado eaters absorbed 8.3 times more alpha-carotene, 13.6 times more beta-carotene, and 4.3 times more lutein than the others. Researchers believe the healthy fats in avocado increase the absorption of these fat-soluble carotenoids, which are associated with a decreased risk of macular degeneration and cataracts. Go green: In the study, 3 tablespoons of avocado was nearly as effective as 6, so spare yourself the extra calories. Use a Hass avocado if possible--it has a higher monounsaturated fat content--or try swapping in another healthy fat source, such as safflower oil, nuts, or olives. 7. Build Muscle: Strength Train + Stretch Weight-training builds strength by causing tiny tears in the muscle, which then quickly repairs itself, ending up bigger and stronger. Fast-track your strength gains by adding static stretching--in which you hold a stretch for 10 to 30 seconds--to your routine. Three studies led by Prevention advisor Wayne L. Westcott, PhD, found that adults who stretched either between or immediately after strength-training exercises developed about 20% more strength than those who only lifted weights. Lift and Reach: Rest at least a minute between sets and use that time to stretch the muscle you've just worked. For instance, if you just did leg extensions, stretch your quadriceps by pulling your right ankle toward your butt while standing on your left leg. Hold each stretch for 20 seconds 8. Avoid Metabolic Syndrome: The Mediterranean Diet + Nuts A Mediterranean-style diet, rich in fruits, vegetables, beans, fish, olive oil, and grains, is associated with everything from weight loss to a reduced risk of Parkinson's and heart disease. Now, new research shows that people with metabolic syndrome--a condition characterized by high cholesterol, blood pressure, and blood sugar and excess belly fat--can reduce these symptoms by adding an extra serving of mixed nuts to the healthful regimen. In a large study, Spanish researchers instructed people at high risk of heart disease to follow the diet with slight variations. Among the group that added 30 g of nuts, the incidence of metabolic syndrome decreased about 14% within a year (as opposed to, say, a 6.7% decline in those who added a little more olive oil). Researchers believe the fiber, potassium, magnesium, calcium, and omega-3 fatty acids in the nuts helped regulate insulin, blood pressure, and inflammation. Healthy snack attack: Participants in the study ate about five walnuts, five hazelnuts, and five almonds daily. Kathy McManus, RD, director of the department of nutrition at Brigham and Women's Hospital in Boston, recommends eating the same amount (approximately 1 ounce) to take the edge off lateafternoon hunger. Sprinkle the mixture over Mediterranean diet-friendly yogurt, hot oatmeal, or a small salad. 9. Fight Fatigue: Eggs + Orange Juice If you don't eat much meat, you may be feeling sluggish because you're not getting enough iron. Reason: Your body can readily absorb iron from meat (heme iron), but only 2 to 20% of the nonheme iron found in veggies, beans, and eggs makes it into your bloodstream. An effective booster: vitamin C. "It's the most potent promoter of nonheme iron absorption," says Elaine Magee, MPH, RD, author of Food Synergy. Vitamin C keeps the iron up to 6 times more soluble--meaning your body can now use 100% of the nonheme iron you eat and stave off fatigue-causing anemia. "C" that you get more iron: Wash down your morning omelet with a glass of C-rich orange juice. Or toss iron-rich tofu and C-dense broccoli into your salad. Keep the cooking to a minimum (or at low temperatures) and cut your produce into thick chunks. Vitamin C is easily destroyed by light, heat, and air. 10. Sidestep Skin Cancer: Caffeine + Cardio Research shows that caffeine and exercise both have anticancer properties. Combined, they offer powerful protection against skin cancer. In research on animals exposed to UVB radiation, Rutgers University scientists learned the pairing increased the animals' ability to destroy skin cancer cells by up to 4 times. Allan H. Conney, PhD, the director of the laboratory for cancer research at the Ernest Mario School of Pharmacy at Rutgers, suspects that caffeine inhibits ATR-1, a genetic pathway that prevents damaged cells from selfdestructing. Both caffeine and exercise also decrease tissue fat, which research shows helps cells deconstruct. Have a cup, then walk: Drink a strong cup of coffee an hour before exercise, recommends Monique Ryan, RD, a registered dietitian and author of Sports Nutrition for Endurance Athletes. (If your blood pressure is elevated, skip the caffeine.) Caffeine can also increase endurance and delay fatigue--helping you walk longer and stronger. Just don't forget the sunscreen. Used with permission of Prevention Copyright© 2009. All rights reserved. Visit our website at: www.californiaheartcenter.org COMMUNITY SHOWS SUPPORT FOR 5K EVENT The first annual Heart & Sole 5K Run/Walk was held on July 19, 2009 in Westwood Village. With over three hundred participants, the event helped to raise needed funds to support the California Heart Center Foundation’s research, education and patient programs. The event also helped to raise awareness about the importance of a heart healthy lifestyle. CHC’s Chief Scientific Officer, Dr. Jon Kobashigawa, thanks supporters. Featuring Tricia Takasugi of KTTV Fox 11 News as Master of Ceremonies, the event also included a special Tribute Circle comprised of heart transplant recipients walking in honor of their organ donors. Heart patients Kim Coleman and Julie Alberti celebrate as they cross the finish line. 100 UCLA Medical Plaza, Suite 600 Los Angeles, CA 90024 Eric Marton, CHC President & CEO, expresses appreciation for MC Tricia Takasugi of KTTV Fox 11 News. Heart transplant recipient Terry Harrington pays a musical tribute to organ donors. 5K Race participants enjoy the Health & Fitness Expo. NON-PROFIT ORG U.S. POSTAGE PAID LOS ANGELES CA PERMIT NO. 639