Lower Uterine Segment Fibroid Complicating
Transcription
Lower Uterine Segment Fibroid Complicating
Case Report Lower Uterine Segment Fibroid Complicating Pregnancy: A Case Report C Jothikala1, Jamila Hameed2, S Radhika2, S Haseena3, Mouhamed Nazar4 1 Post-graduate, Department of Obstetrics and Gynaecology, Vinayaka Mission’s Medical College and Hospitals, Karaikal, Puducherry, India, 2Professor, Department of Obstetrics and Gynaecology, Vinayaka Mission’s Medical College and Hospitals, Karaikal, Puducherry, India, 3Assistant Professor, Department of Obstetrics and Gynaecology, Vinayaka Mission’s Medical College and Hospitals, Karaikal, Puducherry, India, 4Intern, Department of Obstetrics and Gynaecology, Vinayaka Mission’s Medical College and Hospitals, Karaikal, Puducherry, India The uterine fibroids are very common in the reproductive age group. During pregnancy, it may undergo rapid growth and red degeneration. It may get infected during puerperium. Most of the fibroids are asymptomatic. Women with fibroids may have infertility, a tendency for miscarriage, pre-term labor, placental abruption, placenta previa, fetal growth restrictions, fetal anomalies, postpartum hemorrhage, uterine dystocia, malpresentations and increased risk of caesarean. Here, we present 26-year-old primigravida who was admitted with 9 months of amenorrhea and anterior lower uterine segment intramural fibroid of size 7.2 cm × 7.1 cm on the right side. She conceived immediately after marriage. All Investigations were normal. She was delivered by a cesarean section. An alive female baby of 2.5 kg with good Apgar score. The indication was lower uterine segment fibroid. The liquor was meconium stained. There was no sign of intrauterine growth restriction of the baby. The Doppler study, cardio-topography was normal before section. The post-operative period was uneventful. The patient was discharged and came for follow-up after a month and was found to be alright. Keywords: Caesarean section, Leiomyoma, Pregnancy complications INTRODUCTION Leiomyoma is the most common estrogen dependent benign tumor of the uterus occurring in the reproductive age. Asymptomatic myomas can be present in 50% of cases.1 During pregnancy, fibroid may grow in size due to hormones and undergo red degeneration. Growth of leiomyoma is dependent on estrogen production, growth factors and clonal expansion.2 The tumor thrives during the period of greatest ovarian activity. Continuous estrogen secretion, especially when uninterrupted by pregnancy and lactation are thought to be the most important risk factor in the development of myoma. It causes mainly menstrual problems such as menorrhagia, metrorrhagia, dysmenorrhea, and also infertility. Incidence of women suffering infertility is 12-25%.3 In spite of several complications of fibroid in pregnancy, this case had come out successfully with a live baby. CASE REPORT A 26-year-old primigravida, a booked case, got admi ed for safe confinement. She has been a ending ante-natal clinics from the first trimester. She had a dating ultrasound scan done. She had repeated admissions for pain, impending pre-term labor during her antenatal visits. At term, she got admi ed. On clinical examination, nil abnormality was found out, except transverse lie. Medical and surgical history was not significant. Ultrasonography was done. The impression was that of an “anterior lower segment uterine myoma” of size 7.2 cm × 7.1 cm on the right side. Patient was not anemic. Blood pressure was normal. The uterus was term on palpation. It was a transverse lie, fetal heart rate was good. The liquor was diminished (oligohydramnios, amniotic fluid index - 4 cm). The routine blood investigations were normal. Patient was taken up for elective lower segment caesarean section (LSCS) and delivered an alive female baby weighing 2.5 kg and there was huge intramural fibroid 7 cm × 7 cm on the right side of lower segment of the uterus (Figure 1). The uterine cavity closed in two layers without disturbing the intramural fibroid (Figure 2). Patient went in for mild postpartum hemorrhage and managed with uterotonics and blood. Post-operative period was uneventful. She was discharged home on the 8th post-operative day. She came for review with her baby. DISCUSSION Fibroids are usually estrogen dependent benign tumors found in women of reproductive age group, which cause symptoms likes infertility, menstrual problems, pressure symptoms, pain, recurrent miscarriages. Complications in pregnancy are red degeneration, sudden increase in Corresponding Author: Dr. Jamila Hameed, Vinayaka Mission’s Medical College & Hospitals, Karaikal, Puducherry, India. Phone: +91-9444611107. E-mail: [email protected] 18 IJSS Case Reports & Reviews | November 2014 | Vol 1 | Issue 6 Jothikala, et al.: Lower Uterine Fibroid in women with fibroids.8 According to a study in contrast to the usual fact, it shows that women with leiomyomas are at no longer at risk for obstetric complications when compared with women without fibroids.9 Sometimes a huge fibroid in early pregnancy with complication may require myomectomy.10 CONCLUSION Figure 1: Huge intramural fibroid 7 cm × 7 cm on the right side of lower segment of the uterus This lady with the fibroid complicating pregnancy in spite of repeated admissions for threatened abortion, pain, and impending preterm delivery was treated with tocolytics. LSCS was done and had a good fetal outcome. This encourages the obstetrician and gives hope for the patient in an ordinary set up in developing countries. With the discovery of the myomas in the antenatal period, need not alarm the obstetrician and does not usually appear to have an adverse impact on the outcome of the pregnancy. REFERENCES 1. Figure 2: Closing of uterine cavity in two layers without disturbing the intramural fibroid growth, malpresentation, premature labour, premature rupture of membranes, intra-uterine growth restriction, abruption of placenta, placenta previa, retained placenta, postpartum haemorrhage, sub-involution of uterus, decreased perinatal outcome and increased caesarean section rate. Asymptomatic fibroids constitute around 50%. The magnetic resonance imaging, computed tomography and ultrasound are helpful in diagnosis. The submucous fibroids are outlined by hysterosalpingogram. Hysteroscopy and laparoscopy are additional tools in diagnosis in non-pregnant uterus. Fibroid in pregnancy, when the dating scan is done if the fibroid is more than 4 cm and more in number and also the location namely the lower body intramural myoma causes more complications in pregnancy. The rate of spontaneous pregnancy loss is double in fibroid complicating pregnancy, especially is higher with multiple fibroids than single fibroid. Cesarean section rate is also higher in patients with fibroid. 4 Especially when the fibroids are >5 cm is a contraindication for trial labour.5 Sub mucous fibroid are associated with maximum pregnancy loss. 6 The position of the fibroid plays an important role in fertility, especially the submucous and the intramural. Hence, a myomectomy in these cases improves the chance of fertility and maintenance of pregnancy.7 The complications during ante-partum, intrapartum and postpartum are increased IJSS Case Reports & Reviews | November 2014 | Vol 1 | Issue 6 Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol 1990;94:435-8. 2. Levy G, Hill MJ, Beall S, Zarek SM, Segars JH, Catherino WH. Leiomyoma: Genetics, assisted reproduction, pregnancy and therapeutic advances. J Assist Reprod Genet 2012;29:703-12. 3. Jayakrishnan K, Menon V, Nambiar D. Submucous fibroids and infertility: Effect of hysteroscopic myomectomy and factors influencing outcome. J Hum Reprod Sci 2013;6:35-9. 4. Benson CB, Chow JS, Chang-Lee W, Hill JA rd, Doubilet PM. Outcome of pregnancies in women with uterine leiomyomas identified by sonography in the first trimester. J Clin Ultrasound 2001;29:261-4. 5. Klatsky PC, Tran ND, Caughey AB, Fujimoto VY. Fibroids and reproductive outcomes: A systematic literature review from conception to delivery. Am J Obstet Gynecol 2008;198:357-66. 6. Casini ML, Rossi F, Agostini R, Unfer V. Effects of the position of fibroids on fertility. Gynecol Endocrinol 2006;22:106-9. 7. Morgan Ortiz F, Piña Romero B, Elorriaga García E, Báez Barraza J, Quevedo Castro E, Peraza Garay Fde J. Uterine leiomyomas during pregnancy and its impact on obstetric outcome. Ginecol Obstet Mex 2011;79:467-73. 8. Stout MJ, Odibo AO, Graseck AS, Macones GA, Crane JP, Cahill AG. Leiomyomas at routine second-trimester ultrasound examination and adverse obstetric outcomes. Obstet Gynecol 2010;116:1056-63. 9. Azhiken ME, Osemwenkha AP, Orhue AA, Afinotan LU, Osughe OM, Irihogbe I, et al. Huge uterine fibroid complicating early pregnancy: Myomectomy and live birth at term. Pak J Med Sci 2008;24:753-6. 10. Vergani P, Locatelli A, Ghidini A, Andreani M, Sala F, Pezzullo JC. Large uterine leiomyomata and risk of cesarean delivery. Obstet Gynecol 2007;109:410-4. How to cite this article: Jothikala, Hameed J, Radhika, Haseena S, Nazar M. Lower uterine segment fibroid complicating pregnancy: A case report. IJSS Case Reports & Reviews 2014;1(6):18-19. Source of Support: Nil. Conflict of Interest: None declared. 19