Print this article - International Journal of History and Philosophy of
Transcription
Print this article - International Journal of History and Philosophy of
International Journal of History and Philosophy of Medicine 2015; 5: 10504 © Rhazes, LLC. www.ijhpm.org doi: 10.18550/ijhpm.072115.0504 FULL ARTICLE Female Anatomists and Their Biographical Sketches Artineh Hayrapetian, M.D.,1 Peter Oakes, B.A.,1 Fred Bertino, M.D.,2 Mohammdali M. Shoja, M.D.,1,3 Margaret Wood Balch, M.L.I.S., M.A.,4 Anthony D’Antoni, Ph.D.,5 Marios Loukas, M.D., Ph.D.,2 R. Shane Tubbs, M.Sc., P.A.-C., Ph.D.1,2,6 1Pediatric Neurosurgery, Children’s of Alabama, Birmingham, AL, USA 2Department of Anatomical Sciences, St. George’s University, Grenada 3Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 4UAB Historical Collections, Lister Hill Library, University of Alabama at Birmingham, Birmingham, AL, USA 5Department of Pathobiology, City University of New York, New York, New York, USA 6Centre of Anatomy and Human Identification, University of Dundee, UK The rich history of anatomical sciences has been maledominated for various reasons. However, substantial contributions from female anatomists have bolstered this field. Herein, we present a list of 11 selected female anatomists from Europe and North America who are important in the annals of morphological study. Such women have worked alongside their male counterparts to advance the study of the human form. Key words: Anatomy, Europe, History, United States, Women Submitted 18 April 2015; Revision received 15 July 2015; Accepted for publication 21 July 2015; Published online 2 August 2015 “I hope my studies may be an encouragement to other women, especially to young women, to devote their lives to the larger interests of the mind. It matters little whether men Address correspondence to Mohammadali M. Shoja, MD, 1600 7th Avenue South ACC 400, Birmingham, AL 35233, USA. Phone: 2057670575. Fax: 2059399972. E-mail: [email protected] or women have the more brains; all we women need to do to exert our proper influence is just to use all the brains we have.” Florence Rena Sabin (1871–1953) INTRODUCTION Until the eighteenth century, it was unheard of for female students to attend universities,1,2 so there was no opportunity for them to be present in the anatomy theater. In fact, many anatomists of this period believed that dissection was disgusting, and women were reluctant to take part in it.1 Were women truly reluctant or was this simply a convenient excuse for not letting them participate? This raises the question of whether their lack of participation was due to prohibition stemming from an effort to maintain the androcentric culture of anatomical science. Usually, only men could be present during dissection. There is little information about most female anatomists; therefore, it is the aim of this paper to understand the careers and contributions of a select few female anatomists as we know of them today. The history of following women anatomists have been included in the present review: Alessandra Giliani (1307–1326) of Italy Laura Maria Caterina Bassi (1711–1778) of Italy Angelique du Coudray (c.1714 –1794) of France Anna Morandi Manzolini (1716 –1774) of Italy Marie Marguerite Biheron (1719 –1795) of France Maria Magdalena Pettracini (1759 –1791) of Ferrara, Italy Augusta Dejerine-Klumpke (1859 –1927) of the USA Florence Rena Sabin (1871–1953) of the USA Margaret Adaline Reed Lewis (1881–1970) of the USA Elisabeth Caroline Crosby (1888 –1983) of the USA Lucja Frey-Gottesman (1889–1942) of the Austro-Hungarian Empire (presently known as Austria–Hungary) 1. Alessandra Giliani Alessandra Giliani (1307–1326) was probably the first female anatomist in the Western Hemisphere. She was born in San Giovanni in Persiceto, Italy, in 1307. Although it was very uncommon for women to be educated at higher levels during that time, Giliani attended the University of Bologna around 1323.3–7 We know nothing concerning the circumstances of her admission to the University of Bologna. Interested in anatomy, she had to study philosophy as a prerequisite. Mondino de Liuzzi, an anatomist and physician, was one of her instructors at the University of Bologna (Figure 1). Mondino de Liuzzi believed that to have a complete medical 1 Hayrapetian et al. 20 she had knowledge of anatomy, natural history, chemistry, algebra, hydraulics, mechanics, logic, geometry, philosophy, Italian, Greek, Latin, and French.13,14 Bassi earned a doctoral degree in philosophy from Bologna, and, in 1732, at the age of 21, she was invited to become a professor of anatomy at the School of Medicine, University of Bologna.2,3,6,14 Carnival anatomy was an important social event at the university; it was the public dissection that attracted many visitors. Bassi was among the people who attended these events.1 She also held many private classes at her home. In 1738, she married Giovanni Giuseppe Veratti, a lecturer and fellow academic at the University of Bologna, with whom she had 8 children (some sources suggest 12).6,3,13,14,17 The support she received from the church and political officials such as Flaminio Scarselli and Filippo Aldrovandi of the Roman Senate helped her maintain her place at the University. Cardinal Prospero Lambertini (became Pope Benedict XIV in 1740), who had witnessed her doctoral thesis defense at Bologna years earlier, continued to support her. As the head of the church, Pope Benedict XIV founded the Benedettini Academics (a scientific society), and, in 1745, he appointed Bassi as a member of the society.6,17 Bassi died in 1778 and was buried at Bologna’s Corpus Domini.3,6 Figure 1: Mondino de Liuzzi, seated on a chair with a book in his hand, instructing Alessandra Giliani, the first woman anatomist recorded in history (Image courtesy of Wellcome Library, London). The assumption that the long-haired prosector is Alessandra Giliani was made by Garrison (1929).16 education, his students should know the human body by means of dissection.4,5,7,8 Alessandra became his assistant and prepared de Liuzzi’s cadavers for study. She developed a method for draining blood from vessels and replacing it with a colored dye, facilitating the observation of cardiovascular structures.3–5,7,9,10–15 Very little is known about Giliani’s life, but we know that she never married and died in 1326 from an infection. A plaque commemorating her work was placed on the wall of a hospital church in Santa Maria del Mareto in Florence; the image on the plaque depicts a woman busy with prosection as de Liuzzi supervises from his chair and delivers an anatomical lesson.3–5,7,8,11–15 2. Laura Maria Catalina Bassi Laura Bassi (Figure 2) was born in Bologna in 1711.6,12,13,17 Her father was a wealthy lawyer, which afforded her the opportunity to connect with the city’s most affluent people. When Bassi was 13, she was tutored by Gaetano Tacconi, a professor of biology, natural history, and medicine. By age 2 Figure 2: Laura Maria Caterina Bassi (1711–1778) of Italy (Image courtesy of Wellcome Library, London). International Journal of History and Philosophy of Medicine 2015; 5: 10504 Female Anatomists was designed from pink cloth; fabric; and, initially, leather, with real pelvic bones. In later years, she replaced the cadaveric pelvic bones with wicker.18,21–23 In the new flexible models, students could see and feel the baby’s descent and engagement within the birth canal. Sponges were used inside the model to release colored or clear liquids simulating the blood and amniotic fluid, respectively, observed during actual delivery.18,22,23 The machine was engineered to be anatomically correct and included a uterus, a fetal model with fontanelles, intact limbs, and an open mouth with a tongue. This last design allowed the fingers of the accoucheur to enter the orifice up to 5 cm in order to make adjustments to Figure 3: Angelique du Coudray (from Delacoux A. Biographie des sages-femmes célèbres anciennes, moderns et contemporaines. Paris: Trinquart, 1834). 3. Angélique Marguerite Le Boursier du Coudray Angélique Marguerite Le Boursier du Coudray (Figure 3) was prominent during the dawn of modern medicine, expanding the knowledge of midwifery and the practice of obstetrics.15 She was born in Clermont-Ferrand around 1714. In 1740, she finished a three-year course of education under Anne Bairsin and Philibet Magin at the École de Chirurgie and thereafter moved to Paris, where she became the head midwife at Hôtel-Dieu de Paris.3,15 She revised and expanded a textbook of midwifery published in 1667, and published her own Abrégé de l’art des accouchements (Abridgment of the Art of Delivery; Figure 4) in 1759.15,18–22 This textbook contained color plates with 26 anatomical and surgical illustrations for illiterate students studying midwifery.18 Among her extensive obstetrical illustrations, du Coudray also included methods detailing postnatal care of infants, such as the practice of warm-water submersion to prevent hypothermia.19 Angélique du Coudray’s scientific contributions resulted in an overall decrease in the period’s infant mortality rate. At the suggestion of Louis XV, she began educating midwives in rural France in 1759.3,18–22 Between 1760 and 1783, du Coudray brought her knowledge of surgical obstetrics, midwifery, maternal–fetal medicine, and reproductive and fertility medicine to nearly all of France.21 She lectured on anatomy and physiology, surgical techniques, and bioethical principles and detailed the maternal–fetal circulation within the umbilical cord.22 In order to demonstrate the process of childbirth, du Coudray made an obstetrical mannequin.19–23 This life-sized model Figure 4: Title page from Abrégé de l’art des accouchements by Angelique Marguerite Le Boursier du Coudray, 1714 or 5-1794, Delaguette, veuve. A Paris: Chez la veuve Delaguette, imprimeurlibraire, 1759 (Image courtesy of Reynolds Historical Library, the University of Alabama at Birmingham). International Journal of History and Philosophy of Medicine 2015; 5: 10504 3 Hayrapetian et al. sory organs.25 By performing dissections, she discovered the termination of the oblique muscle of the eye.13 Morandi’s reputation extended to England and even Russia,14,25 where Catherine the Great, Empress of all Russia, began to show interest in her work.2,26 Joseph II of Austria also took notice of her and her work.12 She became a member of the Italian Royal Society, the Russian Royal Scientific Association, and the British Royal Society; the University of Milan offered her the chair of anatomy, but she declined the position and decided to remain in Bologna.3,4,13–15,24 She died in 1774 and was buried in the Saint Proculus Church in Bologna, close to Giovanni. After her death, the Medical Institute of Bologna collected all of her models, which are now displayed at the Institute of Science in Bologna.4,11,15,24 Morandi had made a self-portrait and a portrait of her husband from wax; there is also a bust of her at The Pantheon in Rome and at the University Museum.3,12,14,28 5. Mademoiselle Marie-Catherine Biheron (1719 –1795) Mademoiselle Biheron was a French anatomist born in 1719.2,3,12,14 In order to carry out anatomical studies, she hired people to steal cadavers for dissection.1,14 Her teacher, Basseporte, encouraged her to start making anatomical models.2 She considered making artificial models with wool, feather, thread, and waxed paper. In 1759, she was invited by the surgeon Jean Morand to display some of her models to the Academie Royale des Sciences and the Academie de Chirurgie in Figure 5: Anna Morandi Manzolini (1716 –1774) of Italy (Image courtesy of Wellcome Library, London). aid the delivery of a child’s head.22 Angélique du Coudray died in 1794 at the age of 79.21 4. Anna Morandi Manzolini One of the most notable female anatomists in history is Anna Morandi Manzolini (1716 –1774) (Figure 5). She was born in 1716 in Bologna, Italy. Morandi was a sculptor and a wax modeler in Bologna. Her husband was a professor of anatomy at the University of Bologna, where they began to fabricate wax anatomical models.1,3,4,12–15,24,25 Initially, they collaborated with Ercole Lelli for the University of Bologna’s Anatomy Museum. Morandi and her husband then decided to perform all dissections at home where they could also make wax models.24,25 Gradually, they began using unclaimed bodies from the hospital for their dissections.25 Their models (Figure 6) were very accurate and beautiful and were admired by both domestic and foreign visitors. The couple began using these models for teaching anatomy classes.4,25 In her wax models, Morandi included many of the finer parts of the body, such as capillaries and nerves, and the stages of fetal development.4,24 When her husband died in 1755, Morandi replaced him as the professor of anatomy at the University of Bologna, and, in 1756, she received the title of Professor of Anatomy.2–4,12–15,24–27 She specialized in the anatomy of the skeleton, female and male reproductive systems, and sen4 Figure 6: A wax model of Manzolini (Image courtesy of Wellcome Library, London). International Journal of History and Philosophy of Medicine 2015; 5: 10504 Female Anatomists Figure 7: Klumpke and her husband, Professor Joseph Jules Dejerine, looking at a microscopic sample (Image courtesy of Wellcome Library, London). Paris.1,2,14 Biheron became one of the pioneering wax modelers of her day.2,22 She published an advertisement “artificial anatomy” in Paris in 1761.1 The flyer stated that artificial anatomy was the trunk of the body without limbs, with the relationships among parts exactly represented. Her gallery was at her residence on the Vielle Estrapade.1 In 1770, Biheron was invited again to demonstrate a pregnant woman model with movable parts and fetuses. In 1771, she presented her models for the third time to Gustavus, the visiting Crown Prince of Sweden.3,13,15 Biheron lived by teaching and selling her models. As women were not allowed to teach in France, she moved to England. Many students, including Scottish surgeon John Hunter, were influenced by her work.2,12–15,26 ment initially in London, but her family were not happy with the care they received there, so they traveled to Paris and then Germany. They stayed 18 months in Berlin while Anna underwent treatment. In 1868, they returned to the USA. Klumpke’s parents separated in 1871, and she, along with her mother and five siblings, moved permanently to Europe, first to Germany and then to Geneva.30,32,33 Klumpke studied chemistry and natural sciences at an academy of Lausanne.32 In 1875, hearing that a woman named Madeleine Brès has become the first medical doctor in France, she was encouraged to go to Paris.30,32,33 She was admitted to a medical school in Paris in 1877.32 Her anatomy professor during her second year encouraged her to attend a selective externship program in Parisian hospitals, a requirement for graduation.33 Klumpke became one of the first women externs in a Paris hospital. During her externship years, she discovered a paper by Professor Wilhelm Erb concerning superior brachial plexus palsy as a result of trauma, known today as Erb’s palsy.32,33 This ignited her interest in injuries to the brachial plexus. She later identified a case of total brachial plexus radicular paralysis with oculopupillary involvement (Horner’s syndrome).30,33 This observation became the basis for her thesis.30 Her work was published in 1885 in the Revue de Médecine and was awarded the Godard Prize by the 6. Maria Magdalena Petraccini (or Pettracini) Maria Magdalena Petraccini was an Italian anatomist and physician, and a strong advocate of women’s involvement in medical education. Born in 1759 in Florence, Tuscany,3 she studied at the University of Ferrara and majored in surgery. Her husband, Francesco Ferretti (a popular physician in Bagnacavallo), had ties with the university, which allowed his wife the opportunity to study surgery and obstetrics.28,29 Her commissioned work, “Memoria per servire alla fisica educazione dei bambini,” co-authored with her husband, detailed the practice and experience she had accumulated in managing the lives of children and newborns. Maria and her daughter, Zaffira Peretti, were anatomy instructors at the University of Ferrara and University of Bologna, respectively. 7. Augusta Dejerine-Klumpke Augusta Dejerine-Klumpke (Figure 7), a neurologist, neuroanatomist, and pathologist, was the first American female student to intern in a Parisian hospital. She was born in San Francisco on October 15, 1859.30–33 Her sister, Anna, suffered from a femoral fracture that resulted in osteomyelitis, forcing them to seek treatment in Europe.32 Anna received treat- Figure 8: Florence Rena Sabin’s bronze statue by Joy Buba (Image courtesy of Architect of the Capitol). International Journal of History and Philosophy of Medicine 2015; 5: 10504 5 Hayrapetian et al. Figure 9: An intriguing depiction of the dorsal surface of the brainstem in Sabin’s atlas (from An Atlas of the Medulla and Midbrain: a Laboratory Manual, by Florence R. Sabin; Friedenwald Co. Baltimore, Md.: Friedenwald Company, 1901; Image courtesy of Reynolds Historical Library, the University of Alabama at Birmingham). The illustration was created by Max Brödel. 6 International Journal of History and Philosophy of Medicine 2015; 5: 10504 Female Anatomists French Academy of Medicine in 1886; the inferior brachial plexus palsy she described was named Klumpke’s palsy.30–33 In 1880, Klumpke met her future husband, Joseph Jules Dejerine, at the Charité Hospital. With him, she wrote a book on the anatomy of the central nervous system.31–33 She continued her work in neurology, studying secondary degeneration following lesions of the cerebral cortex, connections of Reil’s ribbon (lemnisci), aberrant fibers of the pyramidal tract, the red nucleus, and fibers in the corpus callosum.31 She was one of the first physicians to perform rehabilitation therapy for spinal cord diseases.31 She helped found the French Neurological Society in 1914 and became its first female president.31–33 Klumpke published more than 56 papers on neuroanatomy and neurology, and wrote an autobiography that was translated into English by Bogousslavsky30; she died in 1927 and was buried in the Père Lachaise churchyard next to her husband.32,33 8. Florence Rena Sabin Florence Rena Sabin (Figure 8) was an anatomist, a pioneering medical researcher, a writer, and a physician. She was born in 1871 in Central City, Colorado, and studied zoology at Smith College where she earned her bachelor’s degree in 1893.3–5,7,13,15,24,34–36 Sabin entered The Johns Hopkins University School of Medicine in 1896. Here, Franklin Paine Mall, a renowned anatomy professor and embryologist, became her mentor and role model. One project suggested by Mall was to create a three-dimensional pattern of a newborn baby’s brainstem. This was one of the most important sections of Sabin’s Atlas of the Medulla and Midbrain, published in 1901 (Figure 9). Another of her research interests was the embryology of the lymphatic system. She received her medical degree in 1900, and, in 1902, she became the first female faculty member at Johns Hopkins. She also studied hematopoiesis and angiogenesis in developing organisms and developed methods for studying the origin of the fetal heartbeat. She became the first female president of the American Association of Anatomists in 1924. In 1923, Simon Flexner, director of the Rockefeller Institute for Medical Research, invited her to work with him at the Cellular Studies Department; she started her work there in 1925 and became the first full female member of the Rockefeller Institute.3–5,7,13–15,24,34–37 Sabin retired from the Rockefeller Institute in 1938 and went back to Colorado. In Denver, she was involved in community health and became chair of the Health Committee of Colorado’s Post-War Planning Committee in 1944.4,5,13,35–37 She influenced several reform bills, named “The Sabin Health Laws”,3,7 the goal of which was to protect the residents of Colorado from preventable diseases.15,24 She improved the sewage system and prohibited the import of unpasteurized milk to the city.7 Subsequently, she became chair of the Interim Board of Health and Hospitals of Denver and then Manager of the Denver Department of Health and Charities until 1951.3,13,35,36 In 1925, she became the first woman elected to the National Academy of Science in the USA.3,4,24 When Marie Curie vis- Figure 10: Margaret Adaline Reed Lewis (Image courtesy of Smithsonian Institution Archives, image # SIA2008-5298). ited the USA, Sabin welcomed her as a representative of American women scientists.3,24 In 1931, a Good Housekeeping poll rated her one of the 12 most eminent American women. During her life, she authored over 100 scientific papers and two books. She died on October 3, 1953; Sabin’s statue was erected by the state of Colorado in the National Statuary Hall in Washington D.C.3–5,7,13,14,24,35–38 9. Margaret Adaline Reed Lewis Margaret Adaline Reed Lewis (Figure 10) was an anatomist and physiologist born in 1881 in Kittanning, Pennsylvania.3,5,7,14,39,40 She studied biology and zoology at Bryn Mawr in Pennsylvania (1902–1903 and 1908 –1909), Columbia University (1903–1906), Zurich (1906), and various other universities in Paris and Berlin (1908). She never received a postgraduate degree. From 1904 to 1907, Lewis worked at the New York Medical College for Women as an instructor in physiology, and simultaneously at Barnard College as a lecturer in zoology and at Columbia University as a lecturer in biology. In 1915, she moved to the Department of Embryology at the Carnegie Institution of Washington in Baltimore as a collaborator and then a research associate until 1946, whereupon she became a member of that Institute. She retired in 1958 but continued her membership until 1964.3–5,7,14,40 One of Lewis’s first projects was on the regeneration of crayfish and amphibian embryology. She cultured cells in vitro, a new biological technique at the time. In 1908, in International Journal of History and Philosophy of Medicine 2015; 5: 10504 7 Hayrapetian et al. 10. Elizabeth Caroline Crosby Figure 11: Elizabeth Caroline Crosby at a young age (© UAB Archives, University of Alabama at Birmingham; reproduced with written permission). Berlin, she worked with Rhoda Erdmann and cultured guinea pig spleen cells and bone marrow in salt solution, performing the first mammalian tissue culture.7,14 In her later studies, she focused on oncology and immunology and the genetics of malignant cells. She discovered that abnormal chromosomes were not the basis of cancer etiology; cancer cells sometimes had normal chromosomes. Her work also led to the discovery of cytotoxic therapies that decreased tumor size. During her life, Lewis published 150 papers. She died in July 1970.3–5,7,14,40 Elizabeth Caroline Crosby (Figure 11) was born in October 1888 in Petersburg, Michigan.3,14 She graduated from Petersburg Union High School in 1907 and from Adrian College with a Bachelor of Science in mathematics in 1910. She entered the University of Chicago and began training in neuroanatomy. In 1915, she received a Ph.D. in anatomy.3,4,7,14,41 Her dissertation concerned the forebrain of the American alligator, Alligator mississippiensis. In 1918, she published A Laboratory Outline of Neurology, which described brain dissection with precise instructions.14,35 In 1923, after her father’s death, she left to study at the University of London and at the Central Institute for Brain Research in Amsterdam.14 During 1939 and 1940, she traveled to the Marischal College of the University of Aberdeen, Scotland, to organize their courses in histology and neuroanatomy.4,14,39 She received honorary doctorates from Adrian College. In 1936, she co-authored The Comparative Anatomy of the Nervous System of Vertebrates. She edited the Journal of Comparative Neurology (Figure 12). In 1955, she cooperated with Edgar A. Kahn, Richard C. Schneider, and James A. Taren on a textbook entitled Correlative Neurosurgery.14,41 In 1962, she co-authored a neuroanatomy textbook with Edward Lauer and Tryphena Humphrey entitled Correlative Anatomy of the Nervous System.3,7,35,41 She retired from the University of Michigan in 1958 to become the first Professor Emerita in this school’s history. In 1963, one of her graduate students, Humphrey, received a position in the anatomy department of the University of Alabama, and Crosby would later teach there Figure 12: Elizabeth Crosby with other active editorial board members of the Journal of Comparative Neurology, 1948 (© UAB Archives, University of Alabama at Birmingham; reproduced with written permission). 8 International Journal of History and Philosophy of Medicine 2015; 5: 10504 Female Anatomists as well. Between 1920 and 1958, she taught neuroanatomy to 8,500 students, prepared 38 –39 students for Ph.D., and instructed 30 postgraduate students. Fifteen of these became heads of various departments at the University of Michigan.4,7,14,41 In 1980, at the age of 91, she received the National Medal of Science from President Jimmy Carter for comparative and human neuroanatomy.4,14 In 1982, she published her final book, entitled Comparative Correlative Neuroanatomy of the Vertebrate Telencephalon, which she co-edited with H.N. Schnitzlein of the University of South Florida. During her career, Crosby received 10 honorary doctorates, including an honorary medical degree from the University of Groningen in The Netherlands.41 In 1950, she received the Achievement Award of the American Association of University Women. She was the first non-neurosurgeon to become an honorary member of the American Association of Neurological Surgeons.14,41 Crosby died on July 28, 1983, at the age of 94. 11. Lucja Frey-Gottesman Lucja Frey-Gottesman (Figure 13) was born in November 1889 in Lwów, Eastern Poland, then a part of the AustroHungarian Empire.42 She studied philosophy and mathematics at Lwów University. In 1917, she began medical studies in Lwów, but owing to the Polish–Ukrainian War, she had to stop studying in 1918 and went to work in the neuropsychiatric department of the Lwów State Hospital under the supervision and tutelage of Kazimierz Orzechowski, who became head of the neurology clinic in Warsaw in 1920.38,42–46 Frey then moved to Warsaw for her medical education and graduated in 1923.38,42,46–48 In 1923, she published a paper on auriculotemporal nerve syndrome, now referred to as Frey’s syndrome.44–46 Frey noticed that many post-parotidectomy patients had skin flushing and sweating when they ate. She authored other papers concerning spinal cord degeneration, brain topography, anatomical problems surrounding a Charcot joint, brain cysts and tumors, and amyotrophic lateral sclerosis. During her career, she wrote approximately 43 articles; she was deported to Belzec extermination camp in 1942, and, in the late summer of that year, she was killed by the Nazis during the mass extermination of the ghetto.38,42–44,46–48 CONCLUSIONS Throughout history, little recognition has been given to the brilliant women behind some of the most influential discoveries and contributions to modern anatomical science. Although this review merely scratches the surface of the efforts of these scientists, no accurate history of medical achievement would be complete without the recognition these women deserve. In detailing their work, we hope that future medical and anatomical historians will actively search to expand our knowledge of the women who have influenced anatomical science so that they will be remembered and respected. We hope these unsung heroines will influence a new generation of female anatomists. CONFLICT OF INTEREST STATEMENT The author has no conflict of interest to disclose. SOURCE OF SUPPORT There is no funding source to report for this manuscript. REFERENCES Figure 13: Lucja Frey (from Maciejewska et al. © 2007 Wiley-Liss, Inc.)47 1. Cunningham A. The Anatomist Anatomis’d: An Experimental Discipline in Enlightenment Europe. Burlington, Ashgate Publishing Company, 2010: pp 142–147. 2. Schiebinger L. The Mind Has No Sex? Women in the Origins of Modern Science. Boston, Harvard University Press, 1991: pp 14 – 16, 17–29, 252. 3. Harvey J, Ogilvie M. The Biographical Dictionary of Women in Science: Pioneering Lives from Ancient Times to the Mid-20th Century. New York, Routledge, 2000: pp 88 –89, 126, 305–306, 381, 785–786, 503, 841, 1013, 1140 –1142. 4. Oakes EH. International Encyclopedia of Women Scientists. New York, Facts on File, 2002: pp 78 –79, 133–134, 220 –221, 239, 316 –317. 5. Oakes EH. Encyclopedia of World Scientists. New York, Infobase Publishing, 2007: pp 452, 273–274. 6. Shearer BF, Shearer BS. Notable Women in the Physical Sciences: A Biographical Dictionary. Westport, Greenwood Press, 1997: pp 4–8. 7. Shearer BF, Shearer BS. Notable Women in the Life Sciences: A Biographical Dictionary. Westport, Greenwood Press, 1996: pp 91–97, 145–146, 259 –263, 344 –351. 8. Windsor LL. Women in Medicine. Santa Barbara, ABC-CLIO, 2002: p 85. 9. Stange MZ, Oyster CK, Sloan JE. Encyclopedia of Women in Today’s World, Volume 1. Sage, Thousand Oaks, 2011: p 152. International Journal of History and Philosophy of Medicine 2015; 5: 10504 9 Hayrapetian et al. 10. Carlino A. Books of the Body: Anatomical Ritual and Renaissance Learning. Chicago, University of Chicago Press, 1999: p 172. 11. Huntley T. Women in the Renaissance. New York, Crabtree Publishing Company, 2009: p 13. 12. Hurd-Mead KC. A History of Women in Medicine: From the Earliest of Times to the Beginning of the Nineteenth Century. 1st Ed. Haddam, The Haddam Press, 1938: pp 225, 277, 492, 499–500, 508–510. 13. Ogilvie MB. Women in Science: Antiquity through the Nineteenth Century. Boston, MIT Press, 1986: pp 92, 37, 38, 125, 153–156. 14. Proffitt PA. Notable Women Scientists. Gale Group Inc, 1999: pp 30, 39 – 40, 116 –118, 201, 329 –330, 357, 509 –512. 15. Stanley A. Mothers and Daughters of Invention. New Brunswick, Rutgers University Press, 1995: pp 103–106, 152, 562. 16. Garrison FH. An Introduction to History of Medicine. 4th Edition. Philadelphia, W.B. Saunders Company, 1929. 17. Olsen R. Biographical Encyclopedia of Scientists, Volume 1. Tarrytown, Marshal Cavendish, 1998: pp 109 –111. 18. Gelbart NR. The monarchy’s midwife who left no memoirs. Fr Hist Stud 1996; 19: 9971023. 19. Beal J. Madame Angelique le Boursier du Coudray: a midwife of enlightenment France. Midwifery Today Int Midwife 2013; 105: 29. 20. Cody L. Sex, civility, and the self: Du Coudray, d’Eon, and eighteenth-century conceptions of gendered, national, and psychological identity. Fr Hist Stud 2001; 24: 379 –407. 21. Gelbart NR. The King’s Midwife: A History and Mystery of Madame du Coudray. Berkeley, University of California Press, 1998. 22. Moran ME. Enlightenment via simulation: ”crone-ology’s” first woman. J Endourol 2010; 24: 5–8. 23. Riskin J. Eighteenth Century Wetware. Representations 2003; 83: 97–125. 24. Louise S. Grinstein, Carol A. Biermann, Rose K. Women in the Biological Sciences: A Biobibliographic Sourcebook. Westport, Greenwood Press, 1997: pp 307–309, 458 – 462. 25. Messbarger R. The Lady Anatomist: The Life and Work of Anna Morandi Manzolini. Chicago, University of Chicago Press, 2010. 26. Aldersey-Williams H. Anatomies: A Cultural History of the Human Body. New York, W.W. Norton & Company, 2013: p 81. 27. Keen WW. A Sketch of the Early History of Practical Anatomy. Philadelphia, J.B. Lippincott & CO., 1874: p 8. 28. Petraccini Ferretti Maria Maddalena. Available from: URL: http://scienzaa2voci.unibo.it/biografie/74-petraccini-ferretti-mariamaddalena. Accessed July 20, 2015. 29. Fachini C. ProspettoBiograficoDelle Donne ItalianeRinomatein Letteratura, dal SecoloXIV finoa’ Giorninostril, con unaRispostaa Lady Morgan RiguardanteAlcune Accuse da leiDate alle Donne Italiane Nella sua Opera “L’Italie”. Venezia, DallaTipografia di Alvisopoli 1824; pp 203–204. 10 30. Bogousslavsky J. The Klumpke family–memories by Doctor Déjerine, born Augusta Klumpke. Eur Neurol 2005; 53: 113–120. 31. Schurch B, Dollfus P. The ‘Dejerines’: an historical review and homage to two pioneers in the field of neurology and their contribution to the understanding of spinal cord pathology. Spinal Cord 1998; 36: 78 –86. 32. Shoja MM, Tubbs RS. Augusta Déjerine-Klumpke: the first female neuroanatomist. Clin Anat 2007; 20: 585–587. 33. Ulgen BO, Brumblay H, Yang LJ, Doyle SM, Chung KC. Augusta Déjerine-Klumpke, M.D. (1859 –1927): a historical perspective on Klumpke’s palsy. Neurosurgery 2008; 6: 359 –366. 34. Kaufman M, Galishoff S, Savitt TL. Dictionary of American Medical Biography, Volume II. Westport, Greenwood Press, 1984: p 659. 35. Narine B. Notable Scientists from 1900 to the Present, Volume 4. Farmington Hills, The Gale Group, 2001; pp 1953–1956. 36. Olson R, Smith R. Biographical Encyclopedia of Scientists, Volume 4. Tarrytown, Marshal Cavendish, 1998: pp 1132–1134. 37. Oaks EH. Encyclopedia of World Scientists. New York, Facts on File, New 2001: pp 333–334. 38. Wooley CF. Florence Rena Sabin (1871–1953), William Osler (1849 –1919) and tuberculosis. J Med Biogr 2005; 13: 162–169. 39. Bailey MJ. American Women in Science. Santa Barbara, ABCCLIO, 1998: p 486. 40. Wayne TK. American Women of Science Since 1900. Santa Barbara, Greenwood Publishing Group, 2011: pp 620 –621. 41. Narine B. Notable Scientists from 1900 to the Present, Volume 1. Farmington Hills, The Gale Group, 2001: pp 492–493. 42. Grzybowski A, Sak J. Lucja Frey (1889 –1942): life destroyed by the Holocaust– on the 70th anniversary of her death. Clin Dermatol 2012; 30: 355–359. 43. Burton MJ, Brochwicz-Lewinski M. Lucja Frey and the auriculotemporal nerve syndrome. J R Soc Med 1991: 84: 619 –620. 44. Jacobsen N, Hopkins C. The bullet that hit a nerve: the history of Lucja Frey and her syndrome. J Laryngol Otol 2006; 120: 178 –180. 45. Ibrahim LF, Brenner C, McMenamin J, Webb D. Frey syndrome in neurofibromatosis 1. BMJ Case Rep 2011: bcr0920092286. 46. O’Neill JP, Condron C, Curran A, Walsh A. Lucja Freyhistorical relevance and syndrome review. Surgeon 2008: 6: 178 –181. 47. Maciejewska I, Dziewiatkowski J, Spodnik E. Lucja Frey: a pioneering physician in tragic times. Clin Anat 2007; 20: 588 – 590. 48. Moltrecht M, Michel O. The Woman Behind Frey’s Syndrome: the tragic life of Lucja Frey. Laryngoscope 2004; 114: 2205–2209. International Journal of History and Philosophy of Medicine 2015; 5: 10504