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New Aeris™ Thermal Cycler
07 The
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Medical Website Launched
10 Esco
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Esco Medical Trainings
11 Read
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Esco Goes Gangnam Style
12 Read
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THE LATEST FROM ESCO’S
SUITE OF PRODUCTS
Aeris™ Thermal Cycler is an ideal multi-function PCR amplification
system, which provides real flexibility and reliability with
affordable price.
Key Benefits
Models Available
Saves time when programming with
the intuitive colour touch screen
5 Interchangeable Blocks
• Keeps latest operation records which can deliver the proven reliability of PCR results
AERIS-BG096
• Durable design to guarantee a longer life time of the instruments
AERIS-B4830 Aeris™
• Tm calculator for optimized primer temperature
Extensive applications for researchers to do ‘Long PCR’ and ‘Nested PCR’
AERIS-BG384 Aeris™
Aeris™ Thermal Cycler Gradient Block 96x0.2ml
Thermal Cycler Combined Block (48x0.2ml+30x0.5ml)
Thermal Cycler Gradient Block 384 wells
AERIS-BD048 Aeris™
• Hot lid temperature adjustment to secure the temperature control on the block and to prevent condensation and water evaporation on the hot lid itself.
Thermal Cycler Dual Block (48x0.2ml)
AERIS-B4076 Aeris™
Thermal Cycler 4 Slides In Situ
• Better performance on temperature accuracy
Esco Global Offices
Esco News | Jan 2013
Manama, Bahrain | Beijing, China | Chengdu, China | Guangzhou, China | Shanghai, China | Bangalore, India | Delhi, India
Mumbai, India | Indonesia | Osaka, Japan | Kuala Lumpur, Malaysia | Melaka, Malaysia | Manila, Philippines | Singapore
Seoul, South Korea | South Africa | Salisbury, UK | Philadelphia, PA, USA | Hanoi, Vietnam
CEO LETTER
Dear Partner:
The end of a year and the start of a new one are always an opportune time
for reflection.
2012 has been a year of investments for the Esco group. From new
products, new manufacturing facilities, to new Esco sales companies, we remain
dedicated to our Vision of providing enabling technologies for scientific
discoveries to make human lives healthier and safer.
On the growth front, almost all regions and product categories recorded
healthy growth, with special mention for our freezer product line, which is
now the fastest growing Esco product! Four new Esco sales companies were
established, not to mention the many alliances renewed with our distribution
partners, and footprint expansion in existing territories.
Lin Xiang Qian, CEO
On the manufacturing front, the mother factory in Bintan is now all under one roof in the expanded ETC site. This
has been realized with freezer manufacturing moving into a new factory wing in December 2012. We also congratulate our associates in Kaunas on the first shipments of the EU-made Multi-room incubators!
We can also look back on 2012 as a year of many new products, including a full line of ULT freezers, expanded
range of CO2 incubators and other thermostatics products, launch of a new touchscreen PCR thermal cycler, launch
of Esco Pharma isolation systems, and launch of Esco Medical division IVF equipment products.
Of course, all of the above would not be possible without the dedication of our Esco team members all around the
world, and the support of our supply chain and distribution partners. Thank you and we are looking forward to a
successful 2013 together! Happy new year!
Personal regards,
XQ Lin
Group President and CEO
3
Dr. Shinya Yamanaka Wins 2012 Nobel Prize
in Medicine
Dr. Shinya Yamanaka together with Dr. John Gurdon won last year’s Nobel Prize in Physiology or Medicine for their
groundbreaking work in cellular reprogramming. Their discovery led to great advances in the field of biology, from
cloning to treatment of diseases using a patient’s own cells.
Source: UCSF
Their experiments showed that mature cells taken from the body can be reprogrammed to resemble an embryonic
stem cell. The discovery is the biological equivalent of turning back time.
Their work has changed the belief that mature cells are forever committed to a specialized function. In 1962, Dr.
Gurdon performed a daring experiment in an effort to understand how simple undifferentiated cells become all
other cells in the body. He removed the nucleus of a frog egg and replaced it with a nucleus from a tadpole’s intestinal cell. The egg developed into a healthy tadpole which is a clone of the donor tadpole. His experiment was the
basis for the creation of Dolly the sheep in 1996. Now 79, Dr. Gurdon is a professor at the Gurdon Institute, part of
Cambridge University.
Dr. Yamanaka demonstrated that a mature cell can be turned back into its embryonic-like state just by adding four
genes which are now collectively known as the Yamanaka factors. He first did the experiment using mouse cells and
then human cells in 2007. He transformed the cells into heart, nerve and other human tissues in a lab.
Mature cells reprogrammed into embryonic-like cells can be further manipulated and turned into heart, nerve, muscle and virtually all other tissues types.
Many labs have modified how they do stem-cell research because of Dr. Yamanaka’s breakthrough.
Dr. Shinya Yamanaka serves as the Director and Professor of Kyoto University’s Center for iPS Cell Research and Application (CiRA) and Principal Investigator at the Institute for Integrated Cell-Material Sciences (WPI-iCeMS ), and we
are very much honored of the fact that Esco Biological Safety Cabinets are used in conducting cutting-edge research
and experiments in their laboratories.
Esco is proud to be part of CiRA, and we are honored to support those activities in the background by providing the
researchers around the world with reliable Biological Safety Cabinets.
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Frontier Duo Fume Hood, 5ft/1.5m and 6ft/1.8m
Now Independently Certified to ASHRAE110
Esco is pleased to announced that its Frontier Duo Fume
Hood, 5ft/1.5m and 6ft/1.8m have both been tested
and certified by Invent, UK to meet the requirements
of the ANSI/ASHRAE 110-1995 Standard. This adds to
the Frontier Duo Fume Hood 4ft/1.2m size previously
certified.
Esco Frontier Duo Fume Hood Overview
Esco Frontier Duo Fume hood offers a solution
representing design and engineering innovations
that are at the forefront of fume hood technology.
They are manufactured for the most demanding
laboratory applications providing superior containment
of noxious chemical fumes at a broad range of face
velocities while addressing workers’ comfort through
ergonomic design. Furthermore, all these hoods are
ASHRAE tested on the production line on a sampling
basis.
Esco BSCs at Genzyme, USA
Attesting to the superior quality of Esco BSCs, Sanofi recently purchased 47 units of Labculture®
Reliant Class II, Type A2 Biological Safety Cabinets. This
move is for the expansion of the Genzyme Center in
Cambridge, Massachusetts just outside Boston.
Genzyme is a leading biotech company that Sanofi
acquired back in 2011. Genzyme has been a pioneer in
the development and delivery of transformative therapies for over 30 years. From a tiny start-up with just a
handful of employees, Genzyme has evolved to become
one of the world’s leading biotech companies since it
was founded in 1981. Genzyme has long been known
in the class of rare genetic diseases known as lysosomal storage disorders (LSDs) but have also expanded to
other disease areas such as thyroid cancer and multiple sclerosis. Genzyme now benefits from the reach and resources of one of the world’s largest pharmaceutical companies.
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Esco Wins Order from Wistar Institute to Supply
Biological Safety Cabinets
Esco Technologies, Inc., a world leader in laboratory
equipment, has won orders from Wistar Institute to
supply a significant number of biological safety cabinets
to its newest vivarium and research facilities located in
West Philadelphia.
The Wistar Institute is America’s first independent institution devoted to medical research and training. The
Wistar Institute has evolved from its beginnings as an
anatomical teaching museum to its present-day status
as an international leader in basic biomedical research.
It adds to the prestigious list of customers that includes
the World Health Organization, MIT and Princeton University. The project will be delivered in the first quarter of 2013.
This facility will be equipped with Esco’s Labculture® Class II Type A2 biosafety cabinet which is also the world’s most
certified BSC. Its modern and ergonomic design help ensure a very high level of working comfort for the operators.
Some of the features include the 10 degree sloped front design, low noise levels, warm 5000K lighting and the
popular raised arm rest.
This project also profits from Esco’s close proximity to site. Esco has the ability to provide fast delivery, installation
and technical service support directly right from its Philadelphia head office which also houses its nationwide service
center and warehouse. The increased development of biotech research in the Philadelphia area is an extremely encouraging trend. It will continue to be an important focus area for Esco’s long-term growth.
Esco’s Global Repositioning
Esco may have always been associated with biological safety cabinets, laminar flow cabinets and fume hoods, but it is
now time to change this perception.
With more than over 30 years of experience in
controlling environments, Esco is now a global life
sciences tools provider with sales in over 100 countries.
The group is active in lab equipment (biosafety/laminar
flow cabinets, fume hoods, incubators, freezers and more)
pharma equipment (isolation systems) and medical devices
(IVF/ART equipment).
Manufacturing facilities are located in Asia and Europe.
R&D is conducted worldwide spanning the US, Europe and
Asia. Sales, service and marketing subsidiaries are located in
12 major markets including the US, UK, Singapore, Japan,
China and India. Regional distribution centers are located in
the US, UK, and Singapore.
6
Esco CO2 Incubators’ Worldwide Presence
Esco is proud to announce our growing number of CO2 Incubator customers worldwide ranging from universities,
hospitals, research centers, government institutions and private companies. Some of these organizations include
the prestigious Massachusetts Institute of Technology (MIT) in the US, M.P. Shah Cancer Hospital in India, Ingham
Health Research in Australia, ASTAR in Singapore and Pfizer Animal Health in Belgium, among others. Esco is
looking forward to helping more organizations in achieving their goals by providing quality laboratory equipment.
Esco Unveils the New Aeris™ Thermal Cycler
Esco has yet again come up with another innovation the new Aeris™ Thermal Cycler. The Aeris™ Thermal
Cycler is an ideal multi-function PCR amplification
system which provides real flexibility and reliability
with affordable price.
Polymerase chain reaction (PCR) enables researchers to
produce millions of copies of a specific DNA sequence.
PCR is now a common and often indispensable technique
used in medical and biological research labs for a variety of
applications. These include DNA cloning for sequencing,
DNA-based phylogeny, or functional analysis of genes;
the diagnosis of hereditary diseases; the identification
of genetic fingerprints (used in forensic sciences and
paternity testing); and the detection and diagnosis of
infectious diseases.
The method relies on thermal cycling consisting of cycles of repeated heating and cooling. That is why rapid
temperature ramping, precise temperature control,
block uniformity and flexible segment programming are
essential performance attributes of a thermal cycler.
7
Aeris™ boasts of the following technologies: AeonStar ™, IsoHeat™, SmartDrive™ and AerisLine™.AeonStar™
peltier is qualified to deliver outstanding and precise performance and unique IsoHeat™ temperature control technology which delivers high heating and cooling rates with excellent temperature accuracy and uniformity. SmartDrive™ automatic block recognition increases user convenience while AerisLine™ software enables the remote
control of up to 30 individual units via one PC. Temperature of the hot lid can be adjusted to secure the temperature
control on the block and to prevent condensation and water evaporation on the hot lid itself. Aeris™ offers 5 interchangeable blocks designed to meet critical requirements for different applications. The large memory can hold up
to 250 individual methods or unlimited if you use a USB flash drive or PC.
Compared with Esco’s 1st and 2nd generation PCR, the new Aeris™ is more efficient and user-friendly. It is capable
of self-testing which indicates more detailed information like different sensors and heating and cooling status. This
ensures reliable performance will be achieved before actual run in 3 minutes. One can also speed up the setting
time by storing regular programs on shortcuts. Aeris™ features an intuitive touch screen that helps save time when
programming. It keeps latest operation records which can deliver the proven reliability of PCR results. Its powerful
software meets a variety of experimental requirements, such as gradient PCR, Touchdown PCR, Time release PCR,
In Situ PCR and others.
With all these features and characteristics, there is no doubt that the new Aeris™ Thermal Cycler will soon be the
standard when it comes to DNA amplification.
US Fungal Meningitis Outbreak and the Role of
Esco in Drug Compounding
Drug or pharmaceutical compounding is a common practice wherein a particular pharmaceutical product is created to fit the unique needs of a patient especially for products which are not commercially available due to low
demand. Unfortunately, many tragic incidents causing injury and death due to contaminated or wrongly prepared
compounded drugs have been reported during the past three decades. These incidents spark great public concern
about the quality and safety of compounded drugs and the oversight of the pharmacies that compound them.
8
The latest reported incident is the meningitis outbreak in the US where 368 patients had fungal meningitis and 37
of these had died as of December 10, 2012.1 The outbreak was first reported in October and was traced to fungal
contamination in three lots of medication of preservative-free methylprednisolone acetate (MPA) used in epidural
steroid injections. The medication was packaged and distributed by the New England Compounding Center (NECC)
in Massachusetts. The predominant fungus found is the black mold Exserohilum rostratum. According to specialists in fungal diseases, cases of meningitis caused by black mold are rare making it harder for clinicians to treat the
disease.
At least 20 lawsuits were filed against the NECC. Victims of the outbreak may be entitled to compensation for medical expenses, lost wages, pain and suffering, and more. After launching an investigation, the Massachusetts Board
of Registration in Pharmacy decided to permanently revoke NECC’s license to operate in Massachusetts as well as
the licenses of the company’s three principal pharmacists to fill prescriptions in Massachusetts. All the products of
NECC were also recalled subject to investigation. Two more compounding pharmacies in Massachusetts were also
shut down over sterility concerns after a surprise inspection.
All these hassles and deaths could have been avoided if the responsible parties were stringent enough in following
proper procedures and industry best practices. In the preparation of compounded drugs, it is very important that
the drug preparations to be used are not exposed to any contaminant.
Many pharmacy-related organizations such as the United States Pharmacopeia (USP) have issued recommendations
for quality assurance in drug compounding to improve patient safety. Esco Isoclean® Pharmacy Isolators, premium
solutions for sterile drug compounding, are designed with strict compliance with USP 797 guidelines to provide
superior sterility and maximum operator protection during drug compounding. Isoclean® Isolators provide total
physical separation between the product and the outside environment compared with open front clean air devices
such as laminar flow clean benches and Class II biological safety cabinets. All Esco Isoclean® Pharmacy Isolators
utilize ULPA filters with a typical efficiency of 99.999% at 0.1 to 0.3 microns that provide superior ISO Class 3 air
cleanliness, 100 times better than competing products. The Isocide™ antimicrobial coating on all powder coated
surfaces eliminates 99.9% of surface bacteria within 24 hours of exposure. Isoclean® Isolators feature built-in digital
airflow and pressure displays. Esco offers a complete range of barrier isolators configured for various applications
and requirements.
1
Centers for Disease Control and Prevention (http://www.cdc.gov/hai/outbreaks/meningitis-map.html)
9
Esco Medical Launches Its
New Website
Esco Medical has finally launched its new website on
December 6, 2012. Esco Medical is one of the divisions
of the Esco Group of Companies, the other two being
the laboratory and pharmaceutical equipment divisions.
The launch of the website marks a new milestone in the
continuous growth of the medical division.
The vision of Esco Medical is to support Assisted Reproductive Technologies (ART), such as IVF, by developing
practical and state-of-the-art technological solutions for
improving clinical success rates and patient satisfaction.
Esco Medical is committed to providing world class ART,
worldwide.
The website features the current product offerings of Esco Medical, namely: Esco Miri®, Esco CelCulture® CO2
Incubators and the Labculture® IVF Workstation. All the latest news and events including product releases and
innovations can also be found on the website.
Check out the website at: http://medical.escoglobal.com/
Esco at the 1st International Conference in
Bangladesh on “Biosafety & Biosecurity in
Developing Countries”
Esco is one of the proud sponsors of the recently concluded 1st International Conference in Bangladesh on
“Biosafety & Biosecurity in Developing Countries” and
Pre-Conference Workshop held last December 6-8,
2012.
The pre-conference workshop on December 6 was held
at the Institute of Epidemiology Disease Control & Research (IEDCR) Auditorium and was attended by 80
participants. The first day of the conference proper was
held at the Dhaka University while the second and last
day was held at the Bangabandhu Sheikh Mujib Medical University (BSMMU). Delegates from around 30 different institutes/departments attended the conference.
The event was jointly organized by the BLRI, IEDCR, DU, BSMMU, NSU, DGHS, FAO & icddr,b. The program’s
aim was to generate an exchange of ideas regarding on the various conceptual understanding on biosafety and
biosecurity to develop a strategic road map for biosafety capability and capacity-building nationwide. The topics of
discussion covered laboratory facilities, infectious disease control, crops, livestock, poultry, and biosafety biosecurity
education for enhancing development to meet biosafety challenges at national and regional level.
10
“Indeed the support we have received from ESCO is
great. It was appreciated by the executive committee
and board of advisors,” said Dr. Asadulghani, president
of the Bangladesh Biosafety and Biosecurity Association
(BBBA). He added that the support given by Esco made
the conference “a great event that was first ever organized in Bangladesh”.
Professor Dr. Syed Modasser Ali, Cabinet Minister and
Honorable Adviser to the Honorable Prime Minister of
the People’s Republic of Bangladesh, led the inauguration of the event. Also present at the event as a special
guest is Professor Dr. Pran Gopal Datta, Vice Chancellor
of the Medical University BSMMU and Dr. John Huynh
of Esco. Diamed which is one of the distributors of Esco
also made its presence at the event.
Esco at the 1st Joint Conference of
PAP and the Societies of Pathologists
Esco participated in the 1st Joint Conference of the Pakistan Association of Pathologists (PAP) and the Societies of Pathologists held last December 7-9, 2012 at
the Armed Forces Institute of Pathology (AFIP) Convention Centre in Islamabad, Pakistan. Some of the Esco
products exhibited include the new Miri® Multi-room
Incubator and the CelCulture® CO2 Incubator. Other
associations such as the Pakistan Society of
Haematology and the Infectious Diseases Society of
Pakistan among others also participated in the event.
More than 2000 people participated in the conference.
Daily workshops promoting awareness about biosafety
cabinets and laminar flow hoods were conducted at the
Esco booth.
Esco Medical Products and
Service Trainings
5-7 November 2012
Esco Singapore Headquarters
13-14 December 2012
Holiday Inn London-Heathrow
In order to ensure that Esco’s distribution channels
are well-trained to install, calibrate, maintain, and
respond to technical inquiries pertaining to Esco’s
Medical Products, intensive trainings have been held in
Singapore and London, UK.
The Singapore training event was conducted at the Esco headquarters in the city state in November 2012. It was
attended mainly by representatives from Esco’s global offices as well as distributors from nearby Asian countries. The
training was spread over 3 days that included a factory tour at Esco’s factory in Bintan, where most Esco products
are manufactured.
11
Being a global company, the following training event was held in December almost at the opposite side of the
globe. The training event in London, UK was attended by Esco’s Great Britain office representative as well as
distributor partners from in and around Europe.
The Singapore and London trainings are merely the first of many more to come. As our distribution network
expands and as new and innovative products are launched, it can be expected that more training events will be held
in the coming months.
Esco Presentation with SST Planners
Last December 12, Esco Technologies, Inc. (ETI) conducted a presentation for some of the architects
of Strategic Science and Technology (SST) Planners
at the Esco office in Pennsylvania. SST Planners is a
specialized laboratory consulting design firm
providing laboratory programming and laboratory
planning services to the scientific and architectural
communities.a
The presentation started with Esco’s company profile
followed by a brief overview of all the products Esco
serves around the world, while giving SST Planners an
idea of how Esco manufactures its products and distributes globally. This provided SST Planners with a foundation and an understanding of who Esco is as a company and what the company focus is.
Discussed in detail are Esco’s laminar flow cabinets, fume hoods, and biological safety cabinets. This presentation
gave a more in-depth explanation on how these products work, and the differences between the various models
Esco sells. The pros and cons between the different models were explained in order to demonstrate how one unit
might better serve an end user over another, as well as to help the architects understand how to situate the units
and use them in tandem when planning a layout.
Overall, they were very impressed with both Esco and the presentations themselves.
a
Source: http://www.sstplanners.com/
Esco Goes Gangnam Style
To start the year, some of the staff of Esco Philippines, Inc. (EPI) made a music video of the hit song Gangnam Style.
It features Esco staff from offices in the UK, South Africa, Japan, Bintan and the Philippines. The video was created
to somehow give everyone a positive vibe to start the year. Let’s do GREAT this 2013!
12
Meet Esco at the following events:
5th International Conference of LASA India
Date of Event: 2013-02-07 Until 2013-02-09
Location: Hyderabad, A.P., India
ARABLAB The Expo 2013
Location: Dubai International Convention & Exhibition Centre
(Sheikh Saeed Halls 1, 2, & 3)
Analytic & Laboratory Equipment Expo & Conference
(China Lab 2013)
Location: Guangzhou Jihan Exhibition Center, China
9th International Symposium on Antimicrobial Agents and
Resistance
Location: Kuala Lumpur City Centre, Malaysia
PITTCON Conference & Expo
Location: Pennsylvania Convention Center, Philadelphia, PA, USA
CPhI/P-Mec South East Asia (Pharmaceutical Equipment)
Location: Indonesia
Analytica Vietnam
Location: Ho Chi Minh City, Vietnam
8TH APBA Biosafety Conference 2013
Location: Marriott, Putrajaya, Kuala Lumpur, Malaysia
Esco News is the online publication of Esco Micro
for Esco customer, partners, suppliers and team members.
Published By:
Esco Micro Pte. Ltd.
21 Changi South Street 1, Singapore 486777
Phone: +65 6542 0833
Fax:
+65 6542 6920
Email: [email protected]
Web: www.escoglobal.com
Editor / Writer:
Andrea Naguit
[email protected]
Layout Artist:
Lenbert Alcantara
[email protected]

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