Faculty Brochure
Transcription
Faculty Brochure
SCHOOL OF MATERIALS SCIENCE 2014 National University Corporation Japan Advanced Institute of Science and Technology School of Materials Science Exploring atomic and molecular science using cutting-edge technology, we design functional materials, organize these materials to fabricate advanced devices to be used for the good of society. Materials Characterization and Device Fabrication Physics labs From exploration of new materials to development of next generation electronics and photonics New Materials Design and Synthesis Open Frontier Fields and achieve breakthroughs based on materials science Biofunction and Organization Chemistry labs Biology labs Development of nanostructured materials with novel functions and high performance Bio-guided materials science and harmonization of materials with biofunctions Contents Message from the Dean of the School of Materials Science P1 Admissions and Expenses P2 Financial Support P3 Material Voice P4-6 Materials Characterization and Device Fabrication (Physics) P7-13 New Materials Design and Synthesis (Chemistry) P14-18 Biofunction and Organization (Biology) P19-23 Center for Nano Materials and Technology P24 Green Device Research Center P24 Research Center for Highly Environmental and Recyclable Polymers P25 Research Center for Bio-Architecture P25 Research Center for Simulation Science P25 Cutting-edge Facilities P26-29 Features of the Educational System P30 Support System for International Students P31 Facilities for Students P32 Location P33 Message from the Dean of the School of Materials Science Create Scientific and Technical Innovations by Creating Innovative Materials! The creation of innovative materials is expected to lead to breakthroughs in solving the problems of modern society, such as energy problems, stagnant growth, increase of chronic medical problems, etc. Like the roles that steel and semiconductors served in the past, innovative materials could energize many industries and positively affect a wide range of fields; these materials are connected to realizing scientific and technical innovations. Our School of Materials Science maintains advanced research facilities, such as class 10 super-clean rooms, 800 MHz high resolution superconducting NMR, and aberration-corrected super high resolution analysis TEM. Here, every day top professors from around the world work with a sense of mission to create new science and technology, and to train superior scientists and engineers who can support the technology-based development of Japan. Dean of the Our School of Materials Science applies a tiered, systematic, and detailed School of Materials Science curriculum in education from the basics, and education for people changing Professor to new fields. We have also introduced a multiple-instructor system in which Toshifumi Tsukahara several teachers are assigned as advisors to each student. This system enables us to accept students from various backgrounds, and to provide an environment where each student can fully realize his or her ability. In addition, making use of our international characteristics, we provide training in communicative competence and power of expression to address globalization and career education. Furthermore, we have an original scholarship system, and various systems to economically support students in studying abroad, as well as internships in domestic and foreign companies. The School of Materials Science at Japan Advanced Institute of Science and Technology (JAIST) hopes to provide you with a place for new growth and rapid progress. We hope you can become a scientist or engineer who will show society the great possibilities of materials science, and return the results of our work to society. Your Path Through the Two Years Topic examples for major research START April in the 1st year Admission to JAIST Tentative assignment to a laboratory During this period, focus on taking courses. July in the 1st year Assignment to a laboratory Begin your research study (major and minor researches) for a degree after your final lab assignment. ・Electronic devices made from functional liquids ・DNA manipulation by light and fabrication of DNA computer ・Plastic made from plants ・A new type of solar cells ・Creation of highly-functionalized nano-particles etc. Minor research An opportunity to expand your horizons by working on a research topic different from your main one. GOAL Feb. in the 2nd year Submission and Presentation of the dissertation for the master's degree March in the 2nd year Conferment of a master's degree Career options ・Manufacturers of electronic components and devices ・Companies related to the chemical industry ・Technical engineers in the government and other public organizations etc. 1 Admissions and Expenses Admissions In considering applicants for admission, emphasis is placed on applicants' motivation, their intellectual capabilities, and their skills in conducting research. JAIST admits students from Japan and abroad, including both recent college graduates and persons who are currently employed. For more information, please visit the website at http://www.jaist.ac.jp/english/admission/index.html How to be a JAIST student There are many programs, courses, and scholarships in JAIST. You may become confused and be unable to on a suitable program for yourself. Please read the section entitled “List of Research Groups” carefully, and find a suitable professor or a professor you are interested in, and then send an e-mail to introduce yourself including your financial situation. All the faculty members are seeking excellent students, so they will give you advice on how to become a JAIST student and obtain a scholarship. Financial Aid for International Students In order to provide financially secure graduate school life, JAIST has prepared a variety of original support systems including benefit type scholarships (grants). Please refer to following website. http://www.jaist.ac.jp/english/i_students/scholar.html Cost of Living in JAIST The cost of living at JAIST varies according to each individual's life style. However, most foreign students in JAIST usually spend 50,000 to 70,000 JPY per month, including their accommodations. Entrance Fee/Tuition Fee Divison Master’s Program Screening Fee Entrance Fee 30,000 JPY 282,000 JPY Doctoral Program Tuition Fee 267,900 JPY (semester) 535,800 JPY (year) Entrance Fee Reduction Those who find it difficult to pay the entrance fee because of their financial situation, and are approved as high-achieving students, may be granted a reduction in entrance fees. There is also an entrance fee deferment system. Tuition Fee Reduction Those who find it difficult to pay the tuition fee because of their financial situation, and are approved as high-achieving students, may be granted a reduction in tuition fees. Exemption or Reduction System in case of Disasters Students who find it difficult to pay fees due to emergencies or disasters which occur after their application and/or entrance to JAIST, especially emergencies involving their parents, may also be granted an exemption or reduction in entrance fees or tuition fees. 2 Financial Support Doctoral Research Fellowship (DRF) The purpose of the Doctoral Research Fellowship is to admit outstanding and highly motivated students pursuing a doctoral degree and develop their ability to carry out research as a young researcher by engaging in research activities. The DRF program is open for applications as follows. Students who wish to apply should bring in or mail (express registered mail) the DRF application form to the Admissions Section by Application Deadline stated. 1 Number of Recipients ・Company sponsored applicants ・MEXT scholarship students (including prospective students) ・Foreign government scholarship students (including prospective students) ・Students who will receive a scholarship equivalent to tuition fee from JAIST after entering the doctoral program through the internal entrance exam. ・5D program scholarship students (students who are selected for both the 5D program scholarship and the DRF must select only one of them before enrolling in the doctoral program) Special Type: approx. 15% of all successful applicants for the doctoral program Normal Type: approx. 20% of all successful applicants for the doctoral program 2 Financial Support The Doctoral Research Fellows receive a payment equivalent to entrance fee (only for newly-enrolled student) and tuition fee, and moreover a prescribed salary by engaging in research activities (employment) for a maximum of 3 years after enrolling in the doctoral program. (It is paid as a benefit for the last 6 months.) The hourly wage is 1,600 JPY/hour (tax included). Special Type: 44 hours/month work, approx.70,000 JPY/month (approx. 1,370,000 JPY/year including tuition) Normal Type:19 hours/month work, approx. 30,000 JPY/month (approx. 890,000 JPY/year including tuition) 1. In addition to the above, an equivalent amount of entrance fee is paid to newly-enrolled student. 2. There is a possibility of change in the working hours if the hourly wage is revised. 3. Salary is paid based on actual hours worked. 4. Interim report, results report, and participation in business may be requested by JAIST. 3 4 Application Deadline Please refer to the following website. http://www.jaist.ac.jp/english/i_students/scholar.html 5 Application Documents The DRF application form (prescribed) *Please download the application form the following website. http://www.jaist.ac.jp/english/i_students/scholar.html 6 Selection Process Selection is made based on the admission documents and the DRF application form. The DRF types (special or normal) will be determined during the selection process. 7 Eligibility Requirements Announcement of Results The results for the DRF will be announced with the admission results in writing. Applicants of general admissions,examination for admission on recommendation for overseas residents, and internal doctoral program admissions EXCEPT the following: ・Applicants of examinations for working professionals 8 Contact Student Welfare Section, Japan Advanced Institute of Science and Technology E-mail: [email protected] Japanese Government (MEXT:Monbukagakusho) Scholarship Students are accepted as "research students", and allowed the scholarship as follows: *Tuition: Exemption of examination, entrance and tuition fees (If the grantee moves on to higher education as a nonregular student or fails the entrance examinations, he/she will pay for entrance examinations.) *Transportation: A round trip air ticket (1 round trip only) *Scholarship Research student Monthly 143,000 JPY (2 years maximum) (As of FY2014) Master’s program Monthly 144,000 JPY (The standard course term) Doctoral program Monthly 145,000 JPY (The standard course term) There are two types of selection processes for this scholarship 1 Embassy Recommendation Japanese embassies select and recommend a student for the scholarship. All detailed inquiries should be addressed to the relevant Japanese government office in your country. 2 University Recommendation Generally students eligible for this type of scholarship should be currently enrolled in institutions that are in partnership with JAIST under an agreement on academic exchanges, or in institutions that have research cooperation or faculty exchanges with JAIST. JAIST recommends a student to Monbukagakusho for a scholarship on condition that the institution where a student is currently enrolled recommends him/her and JAIST has consented to accept the student. Application Deadline: Mid January Selection: April – June * Application Deadline and selection period listed above are standard dates and may be subject to change according to the schedule of Monbukagakusho. Scholarships Students Can Apply for After Entering JAIST While most scholarships from local governments or private foundations require students to obtain recommendation from JAIST and submit an application form via JAIST, there are some scholarships that students can apply for themselves. Recently international students have been increasing and it is becoming very difficult to win scholarships after entering Japanese institutes. Therefore, it is very important to secure enough financial funds to pursue your studies. 3 Material Voice Dao Thi Ngoc Anh Maenosono Laboratory Yamaguchi Laboratory My first impression about JAIST is the access to scientific supplies. I have everything I need for my research, from well-equipped laboratories with innovative technical instruments for material synthesis and characterization, to thousands of reference books, hundreds of free-access scientific journals and the valuable advice of outstanding professors. We can always follow the developments in science around the world through JAIST’s well-developed information network. In addition, JAIST gives students chances to join great conferences in other countries. We can present our research, listen to all the comments and advice, discuss and exchange our experiences, learn and enjoy culture. With these excellent conditions, all I have to do is to enjoy research and do my best. This area is especially quiet and peaceful with the beauty of four seasons, which is helpful to us to focus on research and study. If you want to relax after studying hard, it just takes 30 minutes to go downtown and enjoy the city atmosphere of Kanazawa. I’m interested in nature more, so I usually choose to head west to the beach or head east to spectacular Mt. Hakusan. Life in JAIST is very comfortable. We have nice, convenient student housing, various activities and interesting clubs such as dance club, football club, flower arrangement group, tea ceremony, etc. One more special thing I must mention is international friendship of Japanese and foreign students. That’s the most interesting and exciting experience I have. By learning in an international environment, I’ve gained a truly global network of peers who are also working hard to advance their own research. Studying in Japan has been one of the best decisions I’ve ever made in my life. I am one of the first group of students to enroll in the Joint-PhD. Dual Education program. I am so proud to be one of the members of Prof. Yamaguchi’s laboratory, in which the research projects focus on fundamental study of polymer processing operations, considering industrial applications. I researched the material design of high-performance polypropylene based on precise control of molecular orientation, and the final targets of the polymeric materials are to be used for automobile applications. During my stay here, I’ve gotten many opportunities from my advisor to attend both domestic and international conferences. Through these opportunities, I received two awards; one is the Best Poster Presentation of Asian Workshop on Polymer Processing 2010 in Hanoi, Vietnam, and the other is ANTEC 2012 Graduate Student Poster Competition, Ken J. Braney International Award 2012 in Orlando, Florida, USA. Every day as a student in JAIST, I learn not only research using technologically advanced facilities, but also knowledge-sharing in such a multicultural environment. This has enhanced my knowledge of other countries and cultures, and I have met people from all over the world. It is a good chance to grow up independently and widen my horizons, making it not only a beautiful experience but also a useful one. So I have to say that the two and half years I have spent studying here have exceeded my expectations. Finally, I strongly encourage people of all ages to come to study in JAIST, the experience is truly worth it!! Saumya Dabral 4 Panitha Phulkerd Shafiul Alam Ebitani Laboratory Tsukahara Laboratory I am a Dual Degree master’s student from Delhi University, carrying out a one-year research project at JAIST. The reason I decided to come to JAIST was the positive response and praises given to JAIST by previous students from Delhi, for its state-of-the-art research facilities and equipments which help develop a researcher’s mind. Here at JAIST we have access to a variety of analytical instruments, which makes research a lot easier and more fun. JAIST has a large number of international students, so we have a very interesting multicultural environment. Also, it provides us ample opportunities for interacting with different people and learning about various cultures. In our lab itself we have students from Japan, India, China, Thailand and Vietnam, and this makes working in the lab very enjoyable. Living at JAIST has been a great experience both in terms of research and extracurricular activities. JAIST is surrounded by splendid natural beauty, which inspires us to explore the nearby surrounding areas. We usually borrow bicycles from the school itself (since JAIST has a large number of bicycles for students), and during the weekend we all go together to explore the surroundings of JAIST. Also, the JAIST shuttle bus links us to various stations, so we can easily travel to different regions of Japan and enjoy sightseeing. Overall, coming to JAIST has been a very pleasant experience for me. It not only helped me mature as a researcher, but also helped me learn about different cultures. If given a chance, I would like to come here again for a doctoral degree. I am a doctoral student in Tsukahara Lab. on Molecular Biology which gives me an opportunity to explore the chemistry of life and the medical sciences. There were multiple factors that guided me to decide to become a proud member of the JAIST family. Most importantly, JAIST offers a friendly but serious atmosphere for high quality research, which meets my expectations for depth and breadth of education and life quality. JAIST is a hub of multiple cultures. Approximately 25% of students are foreign students. After coming here, I found multiple cultures are living together in a highly harmonic manner, which gives me the sense of globalization of cultures. Coming from a Muslim culture, I did not find any difficulties to follow my culture. This gives me mental satisfaction, and helps me to concentrate on my research. My professor is very kind, and careful in choosing foods for a lab party or any other occasions. Moreover, in JAIST, we have a cultural organization, the JAIST Muslim Circle, JMC in which, being a member, anyone can learn the depth of Muslim culture along with other different cultures. JAIST, research, faculty, and the students have surpassed all my expectations. I expected new friends, but now I have immense feelings of satisfaction, that I have achieved a new family. I expected excellence in research, and am consistently impressed both with the enthusiasm and energy of my professor to nurture me, and with the state-of the art lab facilities. I have noticed that JAIST has a progressive attitude and constant desire to improve. Patrick Degenaar, Ph.D. Reader in Biomedical Electronics School of Electrical and Electronic Engineering University of Newcastle upon Tyne Greetings to all at JAIST from the UK. I am Dr. Patrick Degenaar, a Reader (Associate Prof.) in Biomedical Electronics. Between 1997 and 2001 I was a Monbusho scholar and PhD student in the School of Materials Science at JAIST, studying under Prof. Tamiya. I researched into artificial neuron networks. My interest in coming to JAIST was to access the high tech facilities which allowed my PhD to be a success. My professor was very supportive and built a collaborative environment within his lab. This allowed me to do joint research projects with Tokyo University, eventually leading to my patent and key research papers. Prior to my PhD, I was also able to learn the Japanese language through a 6 month language program at Kanazawa University organised by the Monbusho scheme. Though after ten years, I’m beginning to forget, it is nice to have a basic conversation with Japanese researchers at conferences. Antonio Caraballo, Ph.D. Technical Specialist Pipelines Integrity Management Unit, Saudi Aramco I was one of five students from Colombia selected by the Japanese Government for a Monbukagakusho scholarship. I decided to carry out my graduate studies at JAIST, not only because of the reputation of the school and its ranking, but also because of the high quality of the faculty, its international atmosphere, and the support offered to its international research students. I carried out graduate studies under the guidance of Professor Kawakami, who since then has become a life mentor and a very close friend. After graduating from JAIST, I moved to the United Kingdom and worked in different engineering positions for several companies within the Oil and Gas industry, including operators and consultancy houses. In my current position, I am a Pipeline Technical Specialist for Saudi Aramco, the world’s biggest oil producer. I am certain that JAIST provided me with the vital skills to achieve my career and personal goals, as well as the On a personal level, I have some fond memories of skiing in Ichirino, camping on Mount Hakusan, and cycling over the mountains to Gifu and Toyama, and attending the various matsuri festivals around the prefectures. In Ishikawa, each season is pronounced and allows it’ s own special activities. Kanazawa city is very beautiful and I’ m keen to return one day to visit with my family. Perhaps even climb Hakusan once more with my son. When I returned to Europe, I found there was a great respect for having studied my PhD in Japan. It allowed me to get a post-doctoral position, and later a lectureship position, at Imperial College in London. However, I learned to really appreciate the countryside at JAIST and decided to move from London. I now have my own large laboratory in Newcastle, UK, where I bring together optoelectronics and neuroscience research (http://research.ncl.ac.uk/neuroprosthesis/) and lead a European project (www.optoneuro.eu) on retinal prosthesis. adaptability and abilities to work as part of a team with people from different cultures and backgrounds. At JAIST I experienced on a daily basis the values that have made Japan a success around the world, values such as hard work, discipline, determination, perseverance, integrity and partnership. During my time as a graduate student in Japan, I joined in traditional activities such as Aikido and Karate. I also travelled extensively through the country, and explored the beautiful contrasts between the coastal and mountainous areas. JAIST provided me with an enriching environment in which I could integrate, and learn about Japan’s history, culture and values. All in all, I believe that the education and the personal experiences I acquired as a postgraduate student at JAIST have instilled in me the qualities required to develop an international career, and to improve my cross-cultural skills, which are critical in the global business environment, but which are often overlooked. 5 Material Voice Anis Haque, Ph.D. Associate Director of Students Department of Electrical and Computer Engineering University of Calgary I received my doctoral degree in Materials Science from JAIST in 2002, and currently I am a faculty member with the Electrical and Computer Engineering Department at the University of Calgary in Canada. I love teaching and enjoy doing research. My dream to do research in magnetoelectronics was seeded while I was studying at the University of Cambridge in England. This bloomed at JAIST under Professor Hidenobu Hori’s tutelage. The School of Materials Science at JAIST has outstanding research facilities, including a world-class cleanroom with nanoscale device fabrication and in-situ characterization facilities. I did not know Japanese language before going to JAIST in 1998, but I had no difficulties in my study. Higher-level courses were offered in English. The students in the lab were so friendly that everyone was willing to help me make a smooth transition to a new system and culture, Hak Soo Choi, Ph.D. Assistant Professor of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School I am a faculty member of the Beth Israel Deaconess Medical Center and Harvard Medical School. I am a graduate of the Polymer-Nano Science Program at Chonbuk National University, South Korea and earned my Ph.D. degree in biomaterials and drug delivery systems from JAIST. In 2005, I extended my research into molecular imaging and tumor targeting, and joined the Center for Molecular Imaging at Beth Israel Deaconess Medical Center in Boston, Massachusetts. I was promoted to Instructor in Medicine in 2008, and Assistant Professor of Medicine in 2011 at Harvard Medical School. My laboratory focuses on the development of new diagnostic agents to solve important problems in oncology and clinical medicine, with an emphasis on in vivo imaging and tumor-specific contrast agent development. A theme of study over the last five years has been the interaction of nanoparticles with the body, and the establishment of design parameters to achieve adequate biodistribution and clearance for tumor imaging. 6 and the institute provided me a fulltime tutor for this. After completing my two-year postdoctoral research at Osaka University, I left Japan in 2004. Some of my best Japanese friends at JAIST came to Osaka and had a farewell party for me. JAIST is located in the Mount Hakusan area, and within 20 minutes drive from the Japan Sea. I loved the spectacular scenic beauty of Hakusan. The mountain is a paradise for hiking, skiing, fishing, camping, gliding, and so on. The people in the community around JAIST are very friendly to the foreign students, and they are respectful to foreign culture and religion. I regularly participated in various cultural and social events in the community. The School of Materials Science at JAIST is a perfect place for postgraduate study and I feel proud that I had this opportunity. I still miss JAIST, and I wish I could go back. My research is focused on the development of novel agents for cancer diagnosis, staging, and treatment. Targeted nanoparticles, which are capable of carrying a large “payload” that can be used for disease diagnosis and treatment, are especially important Our recent studies have focused on defining the chemical and physiological properties required for nanoparticles to be cleared effectively. Along a similar theme, we have been systematically probing the relationships among diagnostic agent h y d r o d y n a m i c d i a m e t e r, s h a p e , c h a r g e , a n d hydrophobicity on in vivo biodistribution and clearance. Armed with the ability to a priori engineer small molecules, my final area of interest is the discovery of lead compounds that bind specifically to living cancer cells. I have supervised the Robotic Chemistry Group at the BIDMC Center for Molecular Imaging, which is capable of quickly screening thousands of small molecules against dozens of types of living cancer cells. CMI Retreat 2010, Beth Israel Deaconess Medical Center, Harvard Medical School Mizutani Group Tomitori Group Professor Goro Mizutani Assistant Professor Hien Thi Thu Khuat Professor Masahiko Tomitori Assistant Professor Akira Sasahara E-mail: [email protected] E-mail: [email protected] Symmetry-Sensitive Nonlinear Optical Microscopy Nanoscale Surface Science Nanoprobe Technology Outline: Outline: What images do you expect, if you can map the information of molecular shapes? Such imaging can be done by detecting optical sum frequency generation (SFG) or second harmonic generation (SHG) from materials. We develop SFG and SHG microscopes for detecting non-centrosymmetric species in biomaterials and on surfaces. In figures (a) and (b) below, you see visible and SHG images of a part of a water plant, respectively. Starch is judged to be localized only in the future seed in image (b) and the relevant polysaccharide structures can be analyzed in the SFG images resonant with molecular vibrations. SFG microscopy has also been shown to be the only method to visualize non-destructively the hydrogen distribution on a silicon surface. We aim at the new frontier of surface science at the nanoscale through development of novel instrumentation based on scanning probe microscopy/spectroscopy (SPM/SPS) techniques. SPM can depict images of sample surfaces at atomic resolution using a sharpened tip, which scans the surfaces while maintaining constant tunneling current or force between the tip and the surfaces. Quantum mechanical behaviors can be interestingly revealed by these methods. Our targets include exotic materials such as semiconductors and oxides. We measure the properties of materials, including various reactions and interactions, in order to describe them accurately for future usage in nanomechanical electronic devices. Ge dots on a Si tip Recent selected publications: Recent selected publications: “Absolute second order nonlinear susceptibility of Pt nanowire arrays on MgO faceted substrates with various cross-sectional shapes”, Yoichi Ogata and Goro Mizutani, Applied Physics Letters 103(9), 093107/1-4 (2013) “Selective observation of local carrier dynamics at step bunches on vicinal TiO2 (110) by time-resolved pump-probe second harmonic generation method”, H. Takahashi, Y. Miyauchi, and G. Mizutani, Physical Review B86(4), 045447/1-13 (2012). “Optical second harmonic generation from Pt nanowires with boomerang-like cross-sectional shapes”, Y. Ogata, N. A. Tuan, Y. Miyauchi, and G. Mizutani, Jounal of Applied Physics 110(4), 044301 (2011). “Discovery of deep and shallow trap states from step structures of rutile TiO2 vicinal surfaces by second harmonic and sum frequency generation spectroscopy”, H. Takahashi, R. Watanabe, Y. Miyauchi, and G. Mizutani, Journal of Chemical Physics 134(15), 154704/1-13 (2011). “Optical second harmonic generation at heterojunction interfaces of a molybdenum trioxide layer and an organic layer”, A. B. El Basaty, Y. Miyauchi, G. Mizutani, T. Matsushima, and H. Murata, , Applied Physics Letters 97, 193302 (2010). “XPS and STM Study of Nb-doped TiO2 (110)-(1×1) surfaces”, A. Sasahara and M. Tomitori, J. Phys. Chem. C 117 (2013) 17680. “Lateral distribution of Li atoms at the initial stage of adsorption on TiO2(110) surface”, H. Tatsumi, A. Sasahara and M. Tomitori, J. Phys. Chem. C 116 (2012) 13688. “Local interaction imaging by SiGe quantum dot probe”, Y. Jeong, M. Hirade, R. Kokawa, H. Yamada, K. Kobayashi, N. Oyabu, T. Arai, A. Sasahara and M. Tomitori, Current Appl. Phys. 12 (2012) 581. “Atomic scale analysis of ultrathin SiO2 films prepared on TiO2(100) surfaces”, A. Sasahara, C.L. Pang and M. Tomitori, J. Phys. Chem. C 114 (2010) 20189. “Adsorption state of 4,4”-diamino-p-terphenyl through an amino group bound to Si(111)-7x7 surface examined by X-ray photoelectron spectroscopy and scanning tunneling microscopy”, T. Nishimura, A. Itabashi, A. Sasahara, H. Murata, T. Arai and M. Tomitori, J. Phys. Chem. C 114 (2010) 11109. Recent research funds Recent research funds The Ogasawara Foundation for Research and Development, 2004, G. Mizutani, 200,000 JPY The Ogasawara Foundation for Research and Development, 2005, G. Mizutani, 100,000 JPY JST, CREST, 2006-2010, G. Mizutani, 187,387,000 JPY Grant-in-Aid for Scientific Research (C), MEXT, 2011-2014, G. Mizutani, 7,000,000 JPY The Ogasawara Foundation for Research and Development, 2012, G Mizutani, 170,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2014-2016, M.Tomitori, 3,900,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2014-2015, A. Sasahara, 3,900,000 JPY Grant-in-Aid for Scientific Research (A), MEXT, 2012-2015, M. Tomitori, 44,980,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2010-2012, M.Tomitori, 3,770,000 JPY Grant-in-Aid for Scientific Research (A), MEXT, 2008-2011, M. Tomitori, 49,270,000 JPY Grand-in-Aid for Young Scientists (A), MEXT, 2009-2011, A. Sasahara, 26,780,000 JPY 7 Takamura (Yukiko) Group Suzuki Group Associate Professor Yukiko Yamada-Takamura Assistant Professor Antoine Fleurence Professor Toshi-kazu Suzuki E-mail: [email protected] E-mail: [email protected] Development of Nanomaterials Based on the Understanding of Surfaces and Interfaces Compound Semiconductor Materials and Devices for Ultra-high-speed Electronics Outline: Outline: Modern industry is founded on thin film materials technologies, ranging from protective coatings to electronic devices, and in order to improve their performance, controlling film-substrate interfaces is critical. The surfaces and interfaces become even more important in the growth of nanomaterials and their properties, since the bulk part is reduced and the surfaces and interfaces become dominant. Our aim is to develop new nanomaterials based on the atomistic understanding of surfaces and interfaces, with the support of advanced microscopies, such as scanning tunneling microscopy and transmission electron microscopy. The hottest topic in our group, right now, is the study of Si-version graphene, "silicene" , which is an ultimate Si-made nanomaterial with single-atom thickness. We found this new two-dimensional material while trying to understand the surface structure of diboride thin films grown on Si wafers. "Silicene" is the fruit of successful collaboration with the photoelectron spectroscopy group and the first-principles calculation group in JAIST. For further progress in future ultra-high-speed electronics, including optoelectronics, development of new compound semiconductor devices is important. In our laboratory, we study compound semiconductor materials and their device physics for new electronics, based on narrow-gap semiconductors such as InAs, and also widegap semiconductors such as GaN. In particular, we investigate the heterogeneous integration technologies of these compound semiconductor devices in combination with different materials, which will open up superior or novel functionalities in electronics, leading to "More than Moore" technological diversification. Recent selected publications: “Microscopic origin of the π states in epitaxial silicene”, A. Fleurence, Y. Yoshida, C.-C. Lee, T. Ozaki, Y. Yamada-Takamura, and Y. Hasegawa, Appl. Phys. Lett. 104 (2014) 021605. “First-principles study on competing phases of silicene: Effect of substrate and strain”, C.-C. Lee, A. Fleurence, R. Friedlein, Y. Yamada-Takamura, and T. Ozaki, Phys. Rev. B 88 (2013) 165404. “Mechanisms of parasitic crystallites formation in ZrB2(0001) buffer layer grown on Si(111)”, A. Fleurence, W. Zhang, C. Hubault, and Y. Yamada-Takamura, Appl. Surf. Sci. 284 (2013) 432-437. “Tuning of silicene-substrate interactions with potassium adsorption”, R. Friedlein, A. Fleurence, J. T. Sadowski, and Y. Yamada-Takamura, Appl. Phys. Lett. 102 (2013) 221603. “Experimental evidence for epitaxial silicene on diboride thin films”, A. Fleurence, R. Friedlein, T. Ozaki, H. Kawai, Y. Wang, and Y. Yamada-Takamura, Phys. Rev. Lett. 108 (2012) 245501. “Surface electronic structure of ZrB2 buffer layers for GaN growth on Si wafers”, Y. Yamada-Takamura, F. Bussolotti, A. Fleurence, S. Bera, and R. Friedlein, Appl. Phys. Lett. 97 (2010) 073109. Recent selected publications: “AlGaN-GaN metal-insulator-semiconductor high- electron-mobility transistors with very high-k oxynitride TaOxNy gate dielectric”, T. Sato, J. Okayasu, M. Takikawa, and T. Suzuki, IEEE Electron Dev. Lett. 34 (2013) 375. “Fabrication and characterization of BN/AlGaN/GaN metal-insulatorsemiconductor heterojunction field-effect transistors with sputtering-deposited BN gate dielectric”,T. Q. Nguyen, H.-A. Shih, M. Kudo, and T. Suzuki,Phys. Status Solidi C 10 (2013) 1401. “Analysis of AlN/AlGaN/GaN metal-insulator- semiconductor structure by using capacitance- frequency-temperature mapping”, H.-A. Shih, M. Kudo, and T. Suzuki, Appl. Phys. Lett. 101 (2012) 043501. “Electron distribution and scattering in InAs films on low-k flexible substrates”, C. T. Nguyen, H.-A. Shih, M. Akabori, and T. Suzuki, Appl. Phys. Lett. 100 (2012) 232103. “Carrier recombination lifetime in InAs thin films bonded on low-k flexible substrates”, T. Suzuki, H. Takita, C. T. Nguyen, and K. Iiyama, AIP Advances 2 (2012) 042105. Recent research funds Recent research funds Grant-in-Aid for Scientific Research (A), JSPS, 2014-2017, “Interface control of epitaxial silicene”, Y. Yamada-Takamura, 40,820,000 JPY Grant-in-Aid for Young Scientists (B), JSPS, 2014-2015, “Formation mechanism of epitaxial silicene”, A. Fleurence, 4,160,000 JPY Funding Program for Next Generation World-Leading Researchers, JSPS, 2010-2013, “Surface and interface studies of epitaxial diboride thin films for integration with nitride semiconductors”, Y. Yamada-Takamura, 145,600,000 JPY Grant-in-Aid for Scientific Research (A), MEXT, 2014-2016, T. Suzuki (partial), 10,600,000 JPY. Joint Research with Sony Corporation, 2011-2012, Research on characterization of GaAs MISHEMTs, T. Suzuki, 4,000,000 JPY. Joint Research with Advantest Laboratories Limited, 2010-2013, Research on characterization of compound semiconductors, T. Suzuki, 4,800,000 JPY. Joint Research with Horiba Limited, 2007-2011, Research on device applications of latticemismatched growth, T. Suzuki, 4,400,000 JPY. 8 Mizuta Group Horita Group Professor Hiroshi Mizuta Assistant Professor Manoharan Muruganathan Associate Professor Susumu Horita E-mail: [email protected] E-mail: [email protected] Hybrid Nanoelectronics and Atomic-scale Devices - Emerging Nanotechnologies for ‘More-than-Moore’ and ‘Beyond CMOS’ Era Science and Technology of Low-temperature Thin Film Growth for Electron Devices Outline: Outline: Atomscale materials such as graphene (single carbon layer) and ultrathin SOI (silicon-on-insulator) are used to fabricate ultrasmall transistors, single-molecular sensors and NEMS, and the extreme characteristics of these materials are unveiled. Novel hybrid functional devices - abrupt switch, nonvolatile memory and nanosensor are developed by co-integrating NEMS and conventional devices such as MOSFET and single-electron transistors. Single-electron spin-based quantum information technology is also developed by integrating multiple quantum dots, a nano magnet, a nano electron-spin-resonance (EMR) device and a readout on Si and graphene platform with a long spin decoherence time. Our group researches low-temperature crystallization of Si film on a glass or plastic substrate, and low-temperature formation of an Si oxide (SiO2) film for thin-film transistors. These techniques for lowtemperature film growth are desirable for energy saving, resource conservation, and preventing global warming in the future. We try to make Si films crystallize on glass substrates at less than 300 ºC by using a seed layer of polycrystalline YSZ (yttria-stabilized zirconia). SiO2 films are deposited by thermal reaction between environmentally-safe silicone oil and ozone gas at 200 ºC. We investigate and discuss film growth and material properties scientifically, which will answer your research questions. Fig. 1. TEM image around interface between crystallized Si film and YSZ layer. The Si film o was deposited at 430 C by vacuum evaporation. Now, we are trying tolower Si Crystallization Temperature. Fig. 2. SEM image of SiO 2 film deposited o by silicone oil and ozone gas at 200 C. The film covers the whole trench structures with 200-nm-width and 1300-nm-depth. Recent selected publications: Recent selected publications: “Low pull-in voltage graphene electromechanical switch fabricated with a polymer sacrificial layer “, J. Sun, W. Wang, Manoharan M. and H. Mizuta, in press for Appl. Phys. Lett. (2014) “Raman study of damage extent in graphene nanostructures carved by high energy ion beam“, S. Hang, Z. Moktadir and H. Mizuta, Carbon 72, 233-241 (2014) “Point defect induced transport bandgap widening in the downscaled armchair graphene nanoribbon device” , Manoharan M. and H. Mizuta, Carbon 64, 416 (2013) “VLSI Compatible parallel fabrication of scalable few electron Silicon Quantum Dots “, Y. P. Lin, J. I. Perez-Barraza, M. K. Husain, F. M. Alkhalil, N. Lambert, D. A. Williams, A. J. Ferguson, H. M. H. Chong and H. Mizuta, IEEE Trans. Nanotechnology 12, 897 (2013) “Magnetoresistance in inhomogeneous graphene/meral hybrids “, Z. Moktadir and H. Mizuta, J. Appl. Phys. 113, 083907 (2013) “Electron-tunneling operation of single-donor-atom transistors at elevated temperatures “, E. Hamid, D. Moraru, Y. Kuzuya, T. Mizuno, Le The Anh, H. Mizuta, and M. Tabe, Phys. Rev. B 87, 085420 (2013) “Effect of Crystallization-Induction Layer of Yttria-Stabilized Zirconia on Solid State Crystallization of an Amorphous Si Film” , S. Horita and T. Akahori, J. Appl. Phys. 53 (2014) 030303. “Raman Spectra Analysis of Si Films Solid-Phase-Crystallized on Glass Substrates by Pulse Laser with Crystallization-Induction Layers of Yttria-Stabilized Zirconia” , M. T. K. Lien and S. Horita, Jpn. J. Appl. Phys. 53 (2014) 03CB01. “Low-temperature crystallization of silicon films directly deposited on glass substrates covered with yttria-stabilized zirconia layers” , S. Horita and H. Sukreen, Jpn. J. Appl. Phys. 49 (2010) 105801. “Disturb-free writing operation for ferroelectric gate field-effect transistor memories with intermediate electrodes” , S. Horita and B. N. Q. Trinh, IEEE Trans. Electron Devices 56 (2009) 3090. “Low temperature deposition and crystallization of silicon film on an HF-etched polycrystalline yttria-stabilized zirconia layer rinsed with ethanol solution“, S. Horita and H. Sukreen, Appl. Phys. Express 2 (2009) 04120. “Low-temperature deposition of silicon oxide film from the reaction of silicone oil vapor and ozone gas” , S. Horita, K. Toriyabe, and K. Nishioka, Jpn. J. Appl. Phys. 48 (2009) 035501. Recent research funds Recent research funds Grant-in-Aid for Scientific Research(S), 2013-2018, Development of graphene NEMS hybrid functional devices for autonomous and ultrasensitive integrated sensors, Hiroshi Mizuta, 124,800,000 JPY Grant-in-Aid for Scientific Research(S), 2011-2016, Development of dopant atom devices based on silicon nanostructures, Michiharu Tabe (Shizuoka Univ.), 18,980,000 JPY Grant-in-Aid for Scientific Research(B), 2010-2013, Atom-scale design and characterization technique for single-dopant controlled silicon nanoelectronics, Hiroshi Mizuta, 19,500,000 JPY The Mitani Foundation for Research and Development, 2014, S. Horita, 1.000,000 JPY Grant-in-Aid for Scientific Research (C), JSPS, 2009-2011, S. Horita, 4,680,000 JPY JST, Research Seeds Growth, 2006, S. Horita, 2,000,000 JPY JST, Research Seeds Growth, 2005, S. Horita, 2,000,000 JPY 9 Tokumitsu Group Shimoda Group Professor Eisuke Tokumitsu Professor Tatsuya Shimoda Assistant Professor Takashi Masuda E-mail: [email protected] E-mail: [email protected] Functional Oxide Devices and Their Fabrication Technologies Direct Formation of Electronic Devices Using Functional Solutions Outline: Outline: Since metal oxides have a variety of electrical properties, we can fabricate various components including electrodes and insulators, using oxides and ferroelectric and resistive switching materials. In our group, novel functional electron devices using oxides and their fabrication technologies have been investigated. We have pointed out that the ferroelectric gate insulator can control large charge density and nonvolatile memory function, and we have developed transparent and flexible ferroelectric-gate transistors (FGTs) using oxide channels. In addition, we have successfully fabricated all layers of the FGT, electrodes, gate insulator and channel, using the solution deposition process. We have been investigating solution processes for applications in electronic devices, such as thin film transistors, solar cells, etcetera. Several classes of functional liquid materials are used, which include organic materials, metal oxides, liquid silicon (including its derivatives) and metal nano-particles dispersed in solvent. As for the fabrication process, ink-jet, nano-imprint and self-assembling methods are used both separately and in combination. To control the solution process for making a good device, it is important to study wettability, spreading and micro-patterning behaviors, phenomena during solvent evaporation and so on. Therefore, understanding the intermolecular and surface forces in a specified geometry and material condition is the essential part of our scientific activity. Recent selected publications: Recent selected publications: “Unipolar behavior in grapheme-channel field-effect-transistors with n-type doped SiC source/drain regions”, Y. Nagahisa, Y. Harada, and E. Tokumitsu, Appl. Phys. Lett., 103, (2013) 223503. “A 60 nm channel length ferroelectric-gate field-effect transistor capable of fast switching and multilevel programming”, Y. Kaneko, Y. Nishitani, M. Ueda, E. Tokumitsu, and E. Fujii, Appl. Phys. Lett. 99 (2011) 182902. “Multiagent strategic interaction based on a game theoretical approach to polarization reversal in ferroelectric capacitors”, D. Ricinschi and E. Tokumitsu, J. Adv. Comput. Intell. Informat. 7 (2011) 806. “Low-voltage operation of ferroelectric gate thin film transistors using indium gallium zinc oxide-channel and ferroelectric polymer poly(vinylidene fluoridetrifluoroethylene)”, Gwang-Geun Lee, Y. Fujisaki, H. Ishiwara, and E. Tokumitsu, Appl. Phys. Exp. 4 (2011) 091103. “The flexible non-volatile memory devices using oxide semiconductors and ferroelectric polymer poly(vinylidene fluoride-trifluoroethylene)”, G.-G. Lee, E. Tokumitsu, S.-M. Yoon, Y. Fujisaki, J.-W. Yoon, and H. Ishiwara, Appl. Phys. Lett. 99 (2011) 012901. “Rheology printing for metal-oxide patterns and devices“, T. Kaneda, D. Hirose, T. Miyasako, P. T. Tue, Y. Murakami, S. Kohara, J. Li, T. Mitani, E. Tokumitsu, and T. Shimoda, J. Mater. Chem. C 2 (2014) 40. “Liquid silicon and its application for electronics“, T. Shimoda, and T. Masuda, Jpn. J. Appl. Phys. 53 (2014) 02BA01. “Amorphous Silicon Carbide Films Prepared Using Vaporized Silicon Ink“, T. Masuda, Z. Shen, H. Takagishi, K. Ohdaira, and T. Shimoda, Jpn. J. Appl. Phys. 53 (2014) 031304. “Fabrication of a Solution-Processed Hydrogenated Amorphous Silicon SingleJunction Solar Cell”, T. Masuda, N. Sotani, H. Hamada, Y. Matsuki, and T. Shimoda, Appl. Phys. Lett. 100 (2012) 253908. “Selected Deposition of High-Quality Aluminum Film by Liquid Process”, Z. Shen, Y. Matsuki and T. Shimoda, J. Am. Chem. Soc. 2012, 134, 8034−8037. “Spectral parameters and Hamaker constants of silicon hydride compounds and organic solvents”, T. Masuda, Y. Matsuki, and T. Shimoda, J. Colloid Interface. Sci. 340 (2009) 298. Recent research funds Recent research funds Grant-in-Aid for Scientific Research (B), JSPS, 2012-2014, E. Tokumitsu, 14,000,000 JPY Grant-in-Aid for Exploratory Research, JSPS, 2012-2013, E. Tokumitsu, 3,100,000 JPY Grant-in-Aid for Scientific Research (B), JSPS, 2009-2011, E. Tokumitsu, 13,600,000 JPY Grant-in-Aid for Exploratory Research, JSPS, 2005-2006, E. Tokumitsu, 2,700,000 JPY Grant-in-Aid for Exploratory Research, JSPS, 2004, E. Tokumitsu, 3,600,000 JPY 10 JST-ERATO (Shimoda Nano-Liquid Process Project), JST, 2006-2011, T. Shimoda, 1,780,000,000 JPY JST-ERATO (Shimoda Nano-Liquid Process Project, extended), JST, 2012-2014, T. Shimoda, 294,000,000 JPY JST-Advanced Low Carbon Technology Research and Development Program, 2011-2013, Thin film solar cell by solution process, T. Shimoda, 260,000,000 JPY Iwasaki Group Murata Group Professor Hideo Iwasaki Professor Hideyuki Murata Assistant Professor Heisuke Sakai E-mail: [email protected] E-mail: [email protected] 1mm Creation and Physical Properties of Functional Materials Organic Electronic Devices - An Interdisciplinary Research Field that Integrates Chemistry and Physics Outline: Outline: Preservation of energy source and natural environment are the world wide serious problems. We focus on superconductivity and thermoelectricity. Especially, we have completed the development of special equipment related to evaluation of the thermoelectric figure of merit, ZT which is based on the voltage measurements in thermally isolated condition of the sample. This was successfully applied to the evaluation in microscopic thermoelectric devices. Right now, we are interested in nanoscopic thermoelectricity because of its high thermoelectric performance, where the equipment with high measurement accuracy mentioned above would be inevitably required in new material creation. Research on the properties of organic materials is one of the fields in which Japan has been leading the world. Organic electroluminescent (EL) displays have been commercialized in Japan, and the implications and significance of our success in organic electronic devices have been widely recognized. At Murata Laboratory we are developing organic electronic devices, which are expected to play an important role in the future. Our research interests involve synthesis of new materials and development of novel organic devices such as organic light-emitting diodes (OLEDs), organic solar cells (OSCs) and organic memory transistors (OMTs). Evaluation of the figure of merit, ZT by the voltage measurements Equivalent Laboratory made equipment Vac : ac voltage Vdc : dc voltage Recent selected publications: Recent selected publications: “Thermoelectric Properties of (Bi1-xSbx)2S3 with Orthormbic Structure”, Y Kawamoto and H. Iwasaki, J. Electronic Materials (2014) DOI: 10/s 11664 -013-2742-5. “Development of a Measurement System for the Figure of Merit in the HighTemperature Region, H. Iwasaki, T. Yamamoto, H. Kim and G. Nakamoto”, J. Electronic Materials 42 1840 (2013). “Phase Transition of Josephson Vortices Under High Magnetic Fields up to 30T in Heavily Overdoped YBa 2 Cu 3 O 7−δ Single Crystals”, T. Naito, H. Iwasaki, T. Nishizaki and N. Kobayasi, J. Low Temp. Phys. 159 168 (2010) “Thermal Conductivity and Seebeck Coefficient of 12Cao7Al2O3 Electride with a Cage Structure”, S. W. Kim, R. Tarumi, H. Iwasaki, H. Ohta, M. Hirano, and H. Hosono, Rhys. Rev. B80 075201-1 (2009) “Nanostructured Poly(3- hexylthiophene-2,5-diyl) Films with Tunable Dimensions through Self-Assembly with Polystyrene,V. Vohra, O. Notoya, T. Huang, M. Yamaguchi, H. Murata, Polymer, 55, 2213-2219 (2014) “Uniaxial macroscopic alignment of conjugated polymer systems by directional crystallization during blade coating “B. Dörling, V. Vohra, T. T. Dao, M. Garriga, H. Murata and M. Campoy-Quiles, J. Mater. Chem.C, 2, 3303- 3310 (2014). “Horizontally oriented molecular thin films for application in organic solar cells’, T. Matsushima, H. Matsuo, T. Yamamoto, A. Nakao, H. Murata, Sol. Energy Mater. Sol. Cells, 123, 81-91 (2014). “Controllable threshold voltage of a pentacene field-effect transistor based on a double-dielectric Structure”, T. T. Dao, T. Matsushima, R. Friedlein, H. Murata, Org. Electron., 14, 2007-2013 (2013) “Improved initial drop in operational lifetime of blue phosphorescent organic light emitting device fabricated under ultra high vacuum condition”, H. Yamamoto, J. Brooks, M. S. Weaver and J. J. Brown, T. Murakami and H. Murata, Appl. Phys. Lett., 99, 033301 (2011). Recent research funds Recent research funds Research Fund with Quantum Design Japan Ltd., 2012, H. Iwasaki 1,500,000 JPY Joint Research Fund with Komatsu Ltd. 2011, H. Iwasaki 750,000 JPY Joint Research Fund with Komatsu Ltd. 2010, H. Iwasaki 750,000 JPY CEREBA, NEDO, 2013-2014, H. Murata, 4,000,000 JPY JSPS-FIRST (OPERA), 2009-2013, H. Murata, 50,000,000 JPY Grants-in-Aid for Scientific Research on Innovative Areas, JSPS, 2008-2012, H. Murata, 24,200,000 JPY Grants-in-Aid for Scientific Research (A), JSPS, 2008-2011, H. Murata, 38,856,000 JPY Green IT Project, NEDO, 2008-2009, H. Murata, 45,151,000 JPY 11 Ohdaira Group Koyano Group Associate Professor Keisuke Ohdaira Associate Professor Mikio Koyano E-mail: [email protected] E-mail: [email protected] Development of Si-based Next-generation Solar Cells Through Novel Process Technologies Thermoelectric Conversion and Condensed-Matter Physics Outline: Outline: Solar cells fabricated using silicon (Si), which is abundant on earth, occupy a high share of the present world market, and will also be the mainstream of photovoltaic technology in the future. However, further cost reduction and efficiency improvement are required for our Si-based solar cells, and we need another technological breakthrough. In this lab, we focus our attention on recent process technologies, such as flash lamp annealing (FLA) for the rapid formation of polycrystalline Si films, and catalytic chemical vapor deposition (Cat- CVD) for excellent surface passivation on crystalline silicon. Also, in cooperation with Prof. Shimoda, we are using liquid Si for very cost-effective production of amorphous Si files for use in solar cells. Thermoelectric conversion technology has been attracting a great deal of attention as a means to solve current energy problems. This technology enables direct alternating conversion between poor quality thermal energy and high-quality electric energy. We are identifying various properties of thermoelectric materials and their relevant compounds, and developing new nano-composites using advanced equipment and innovative methods. Especially, our laboratory has developed new high-temperature Pb&Te-free thermoelectric materials with complex structures. We have recently been conducting further research on these materials, and developing Bi-Sb-based low-temperature thermoelectric materials. Thermoelectric cooling Thermoelectric generation Recent selected publications: Recent selected publications: “A Method to evaluate explosive crystallization velocity of amorphous silicon films during flash lamp annealing”, K. Ohdaira, Can. J. Phys. 92 (2014) 718. “Deposition of moisture barrier films by Cat-CVD using hexamethyldisilazane”, K. Ohdaira and H. Matsumura, Jpn. J. Appl. Phys. 53 (2014) 05FM03. “Effect of annealing and hydrogen radical treatment on the structure of solutionprocessed hydrogenated amorphous silicon films”, Y. Sakuma, K. Ohdaira, T. Masuda, H. Takagishi, Z. Shen, and T. Shimoda, Jpn. J. Appl. Phys. 53 (2014) 04ER07. “Passivation quality of a stoichiometric SiNx single passivation layer on crystalline silicon prepared by Cat-CVD and successive annealing”, Trinh Cham Thi, K. Koyama, K. Ohdaira, and H. Matsumura, Jpn. J. Appl. Phys. 53 (2014) 022301. “Liquid-phase explosive crystallization of electron-beam-evaporated a-Si films induced by flash lamp annealing”, K. Ohdaira and H. Matsumura, J. Cryst. Growth 362 (2013) 149. “Flash-lamp-induced explosive crystallization of amorphous germanium films leaving behind periodic microstructures”, K. Ohdaira and H. Matsumura, Thin Solid Films 524 (2012) 161. “Development of thermal conductivity measurement system using the 3ω method and application to thermoelectric particles”, S. Nishino, K. Suekuni, K. Ohdaira, and M. Koyano , J. Electronic Materials (2014) DOI: 10.1007/s11664-014-2993-9. “Structural and thermoelectric properties" of Cu6Fe4Sn12Se32 single crystal”, K. Suekuni, K. Tsuruta, H. Fukuoka, and M. Koyano, J. Alloys and Compounds, 564 (2013) 91. “Thermoelectric Properties of Mineral Tetrahedrites Cu 10 Tr 2 Sb 4 S 13 with Low Thermal Conductivity”, K. Suekuni, K. Tsuruta, T. Ariga, M. Koyano, Applied Physics Express, 5 (2012) 051201. “Single crystal growth of Bi-Sb-Te thermoelectric materials by halide chemical vapor transport technique”, M. Koyano, J. Tanaka, K. Suekuni and T. Ariga, J. Electronic Materials, 41 (2012) 1317. “Measurement of Local Peltier Constant at a Micro Contact”, M. Koyano, and N. Akashi, J. Electronic Materials, 37 (2009) 1037. Recent research funds Recent research funds Adaptable & Seamless Technology Transfer Program through Target-driven R&D (A-STEP), JST, 2012-2013, Development of the high-productive technology of polycrystalline silicon films for solar cells, K. Ohdaira, 1,300,000 JPY Strategic Basic Research Programs PRESTO, 2009-2013, JST, Formation of high-quality polycrystalline silicon films on glass substrates by flash-lamp-induced crystallization, K. Ohdaira, 40,000,000 JPY Grant-in-Aid for Scientific Research (C), 2010-2012, M. Koyano, 3,400,000 JPY 12 Akabori Group Oshima Group Associate Professor Masashi Akabori Associate Professor Yoshifumi Oshima E-mail: [email protected] E-mail: [email protected] Spintronics in Semiconductor Nanowires Nanomaterial Science by transmission electron microscope Outline: Outline: Spintronics involves controlling not only electric charge but also spin direction for future information technology. The most typical spintronics device using a semiconductor is a spin field-effect transistor (spin-FET), which consists of a semiconductor channel having large spin-orbit coupling (InAs, InGaAs, InSb, InGaSb etc.) and ferromagnetic metal (FM) electrodes. From now, we plan to use semiconductor nanowire (NW) as the channel, and spin relaxation (caused by the spin-orbit coupling and elastic scattering) is expected to be suppressed in the spin-FET. Therefore, we investigate NW-FM hybrid structures for future spintronics applications. We have developed an experimental system of combining a scanning tunneling microscope (STM) with ultra-high vacuum transmission electron microscope (TEM) and directly obtained relationship between atomic structure and electrical conductance of nanoscaled material. For example, quantization phenomena of gold contacts have been clarified. We will devise such unique experimental systems based on TEM and clarify relationship between atomic structure and physical and/or chemical properties of frontier materials. Our final goal is discovery of frontier materials, which is based on understanding physical and/or chemical properties at an atomic scale. Recent selected publications: Recent selected publications: “Magneto-transport properties of InAs nanowires laterally-grown by selective area molecular beam epitaxy on GaAs (110) masked substrates”, M. Akabori and S. Yamada, AIP Conf. Proc., Vol. 1566, pp. 219-220 (2013). “High-efficient long spin coherence electrical spin injection in CoFe/InGaAs two-dimensional electron gas lateral spin-valve devices”, S. Hidaka, M. Akabori, and S. Yamada, Appl. Phys. Express, Vol. 5, pp. 113001-1-3 (2012). “Selective area molecular beam epitaxy of InAs on GaAs (110) masked substrates for direct fabrication of planar nanowire field-effect transistors”, M. Akabori, T. Murakami, and S. Yamada, J. Crystal Growth, Vol. 345, pp. 22-26 (2012). “Spin-orbit coupling and phase coherence in InAs nanowires”, S. Estévez Hernández, M. Akabori, K. Sladek, Ch. Volk, S. Alagha, H. Hardtdegen, M. G. Pala, N. Demarina, D. Grützmacher, and Th. Schäpers, Phys. Rev. B, Vol. 82, pp. 235303-1-7 (2010). “Influence of growth temperature on the selective area MOVPE of InAs nanowires on GaAs (111) B using N2 carrier gas”, M. Akabori, K. Sladek, H. Hardtdegen, Th. Schäpers, and D. Grützmacher, J. Crystal Growth, Vol. 311, pp. 3813-3816 (2009). “Reversible Contrast in Focus Series of Annular Bright Field Images of a Crystalline LiMn2O4 Nanowire”, S. Lee, Y. Oshima, et al., Ultramicroscopy 125 (2013) 43-48. “In situ TEM observation of controlled gold contact failure under electric bias”, Y. Oshima and Y. Kurui, Phys. Rev. B 87(R) (2013) 081404 “Quantitative Annular Dark Field STEM Image of Silicon Crystal using a Large Convergent Electron Probe with a 300-kV Cold Field Emission Gun”, S. Kim, Y. Oshima, et al., J. Elect. Micro. 60 (2011) 109-116. “One-by-One Introduction of Single Lattice Planes in a Bottlenecked Gold Contact during Stretching”, Y. Oshima, Y. Kurui and K. Takayanagi J. Phys. Soc. Jpn. 79 (2010) 054702. Editor’s Choice “Direct Imaging of Lithium Atoms in LiV2O4 by a Spherical Aberration Corrected Electron Microscope”, Y. Oshima, et al. J. Elect. Micro. 59 (2010) 457. “Detection of arsenic dopant atoms in a silicon crystal using a spherical aberration corrected scanning transmission electron microscope”, Y. Oshima, Y. Hashimoto, et al., Phys. Rev. B 81 (2010) 035317. Recent research funds Recent research funds Grant-in-Aid for Scientific Research (C), JSPS, 2012-2014, M. Akabori, 4,100,000 JPY. Grant-in-Aid for Young Scientists (B), JSPS, 2010-2011, M. Akabori, 3,200,000 JPY. Grant-in-aid for Scientific Research C, 2010-2012 Y. Oshima, 3,500,000 JPY JST-PRESTO, 2008-2011, Y. Oshima, 40,000,000 JPY Research Grant, Renesas Electronics, 2011-2013, Y. Oshima, 3,000,000 JPY JST-CREST, 2011-2014, K. Takayanagi, 200,000,000 JPY JST-CREST, 2004-2010, K. Takayanagi, 500,000,000 JPY 13 Matsumi Group Nagao Group Professor Noriyoshi Matsumi Assistant Professor Raman Vedarajan Associate Professor Yuki Nagao E-mail: [email protected] E-mail: [email protected] Design of Energy Materials using Hetero Atom Chemistry Nanoprotonics – Creation of Emergent Chemical Devices – Outline: Outline: Today, lithium secondary batteries are attracting much attention, not only for use in various mobile devices but also in automobiles, solar energy storage systems and so forth. However, common electrolytes generally show limited selectivity for lithium transport. Therefore, we are developing various electrolytes, mainly with anion receptor or with highly-dissociable lithium salt structure, making the most of heteroatom chemistry. At the same time, since the most important matter is safety problem, we are conducting studies for creation of flame-retardant electrolytes for a new class of batteries. Fuel cells, which generate electricity through the reaction of hydrogen with oxygen to produce water, are ideal power sources for use by future generations. They are suitable for use by a low-carbon society. Protonics is based on integrated sciences and technologies using hydrogen. However, more research is necessary for application to the development of the Pt-free electrocatalysts and fuel cells. We design and create fuel cells using the concepts of "nanoprotonics" and "chemical devices" to create nanoprotonics fuel cells. Furthermore, we are developing technologies for future use in the energy research area, and also for many related research areas that can benefit from these concepts. Recent selected publications: Recent selected publications: “π-Conjugated polycarbazole-boron complex as calorimetric fluoride ion sensor” , R. Vedarajan, Y. Hosono, N. Matsumi, Solid State Ionics, 262 (2014) 795. “Design of organic-Inorganic hybrid electrolytes composed of borosilicate and allylimidazolium type ionic liquids” , K. S. Smaran, R. Vedarajan, N. Matsumi, Int. J. Hydrogen Energy, 39 (2014) 2936. “Synthesis of imidazolium salt-terminated poly(amidoamine)-typed POSS-core dendrimers and their solution and bulk properties” , K. Naka, R. Shinke, M. Yamada, F. D. Belkada, Y. Aijo, Y. Irie, S. R. Shankar, K. S. Smaran, N. Matsumi, S. Tomita, S. Sakurai, Polym. J, 46 (2014), 42. “Synthesis of boric ester type ion-gels by dehydrocoupling of cellulose with hydroboranes in ionic liquid” , N. Matsumi, N. Yoshioka, K. Aoi, Solid State Ionics, 226 (2012) 37. “Ionic liquid pillar[5]arene:Its ionic conductivity and solvent-free complexation with a guest” , T. Ogoshi, N. Ueshima, T. Yamagishi, Y. Toyoda, N. Matsumi, Chem. Commun., 48 (2012) 3536. N. Matsumi, SPSJ Award for the Outstanding Paper in Polymer Journal Sponsored by ZEON (2009) “Proton conductivity enhancement in oriented, sulfonated polyimide thin films”, K. Krishnan, H. Iwatsuki, M. Hara, S. Nagano, Y. Nagao, J. Mater. Chem. A 2 (2014) 6895. “Effects of Nafion impregnation using inkjet printing for membrane electrode assemblies in polymer electrolyte membrane fuel cells”, Z. Wang, Y. Nagao, Electrochim. Acta 129 (2014) 343. “Surface proton transport of fully protonated poly(aspartic acid) thin films on quartz substrates”,Y. Nagao, T. Kubo, Appl. Surf. Sci., accepted.DOI: 10.1016/j.apsusc.2014.06.085. “Influence of Confined Polymer Structure on Proton Transport Property in Sulfonated Polyimide Thin Films”, K. Krishnan, T. Yamada, H. Iwatsuki, M. Hara, S. Nagano, K. Otsubo, O. Sakata, A. Fujiwara, H. Kitagawa, Y. Nagao, Electrochemistry, accepted. “Enhancement of Proton Transport in an Oriented Polypeptide Thin Film”, Y. Nagao, J. Matsui, T. Abe, H. Hiramatsu, H. Yamamoto, T. Miyashita, N. Sata, H. Yugami, Langmuir, 29 (2013) 6798. “Highly Oriented Sulfonic Acid Groups in a Nafion Thin Film on Si Substrate”, Y. Nagao, J. Phys. Chem. C 117 (2013) 3294. Recent research funds Recent research funds NEDO Grant for Industrial Technology Research, 2009-2013, Design of Organic-Inorganic Hybrid Type Ion-gels, N. Matsumi, 40,000,000 JPY TOYOTA Advanced Technology Collaborative Foundation, 2013-2014, N. Matsumi (Title and amount are not in public.) The Ogasawara Foundation for the Promotion of Science & Engineering, 2014 – 2015, 2,500,000 JPY The Kyoto Technoscience Center, 2014, 1,000,000 JPY NEXT Program, JSPS, 2011-2014, Y. Nagao, 66,000,000 JPY PRESTO, JST, 2010-2011, Y. Nagao, 15,138,000 JPY The Foundation Hattori-Hokokai, 2010-2011, Y. Nagao, 1,000,000 JPY TEPCO Memorial Foundation, 2010, Y. Nagao, 830,000 JPY 14 Ebitani Group Maenosono Group Professor Kohki Ebitani Assistant Professor Shun Nishimura Professor Shinya Maenosono Assistant Professor Derrick M. Mott E-mail: [email protected] E-mail: [email protected] Nano-Structured Heterogeneous Catalysts for Biomass-Derived Material Conversion into Valuable Chemicals Nanoparticle Science and Technology From Synthesis to Applications Outline: Outline: Problems concerning energy, resources, and health will be solved by converting inexpensive materials into highly valuable compounds with high atom efficiency and low E-factor of the chemical reaction. Our lab is, therefore, focusing on development of nano-structured heterogeneous catalysts for efficient transformations of biomassderived materials into value-added chemicals. Using a one-pot sequential reaction system consisting of solid acid and base catalysts, various sugars can be converted into furfurals, which are further oxidized to the corresponding carboxylic acids in water with molecular oxygen. Fine structure of the catalytically-active sites has been determined by XAFS using synchrotron radiation facility. Nanoparticles (NPs) have intermediate properties between atoms (molecules) and bulk crystals. We explore the frontiers of synthesis, higher-order structuring, and functionalization of NPs. In addition, we aim to develop practical applications of NPs in collaboration with industry. Our research in JAIST has focused on two main areas of interest in the field of materials chemistry and nanotechnology. The first area involves wet chemical synthesis of semiconductor NPs with controlled size, shape and composition for optoelectronic and thermoelectric device applications. The second area is focused on the synthesis and biological application development of monometallic and alloyed multimetallic NPs. Recent selected publications: Recent selected publications: “Base-free chemoselective transfer hydrogenation of nitroarenes to anilines with formic acid as hydrogen source by reusable heterogeneous Pd/ZrP catalyst”, J. Tuteja, S. Nishimura, and K. Ebitani, RSC Adv. in press. “Synthesis of high-value organic acids from sugars promoted by hydrothermally loaded Cu oxide species on magnesia”, H. Choudhary, S. Nishimura, and K. Ebitani, Appl. Catal. B: Environ. 162 (2015) 1. “Effect of stabilizing polymers on catalysis of hydrotalcite-supported platinum nanoparticles for aerobic oxidation of 1,2-propanediol in aqueous solution at room temperature”, D. Tongsakul, S. Nishimura, and K. Ebitani, J. Phys. Chem. C 118 (2014) 11723. “Production of γ–valerolactone from biomass-derived compounds using formic acid as a hydrogen source over supported metal catalysts in water solvent”, P. A. Son, S. Nishimura, and K. Ebitani, RSC Adv. 4 (2014) 10525. “Direct synthesis of 1,6-hexanediol from HMF over a heterogeneous Pd/ZrP catalyst using formic acid as hydrogen source”, J. Tuteja, H. Choudhary, S. Nishimura, and K. Ebitani, ChemSusChem 7 (2014) 96. “Multicore magnetic FePt nanoparticles: controlled formation and properties”, L. A. W. Green, T. T. Trinh, D. Mott, S. Maenosono, and T. T. K. Nguyen, RSC Adv. 4 (2014) 1039. “Gold core wüstite shell nanoparticles: suppression of iron oxidation via the electron transfer phenomenon”, P. Singh, D. Mott, and S. Maenosono, ChemPhysChem 14 (2013) 3278. “Chemical synthesis of blue-emitting metallic zinc nano-hexagons”, M. T. Nguyen, T. T. Trinh, D. Mott, and S. Maenosono, CrystEngComm 15 (2013) 6606. “Electronic transfer as a route to increase the chemical stability in gold and silver core-shell nanoparticles”, D. M. Mott, A. T. N. Dao, P. Singh, C. Shankar, and S. Maenosono, Adv. Colloid Interface Sci. 185-186 (2012) 14. “Manipulation of the electronic properties of gold and silver core−shell nanoparticles”, D. Mott and S. Maenosono, Functional Nanoparticles for Bioanalysis, Nanomedicine, and Bioelectronic Devices Volume 1 (ACS Symposium Series), Edited by Maria Hepel and Chuan-Jian Zhong, Chapter 13, pp.327-358, American Chemical Society (2012) Recent research funds Recent research funds Grant-in-Aid for Scientific Research (C), MEXT, 2009-2011, K. Ebitani, 3,600,000 JPY Intellectual Property Promotion Highway, JST, 2012, S. Nishimura, 3,000,000 JPY Grant-in-Aid for Scientific Research (C), MEXT, 2010-2012, S. Maenosono, 3,630,000 JPY Research Grant, The Mitani Foundation for Research and Development, 2012, S. Maenosono, 1,000,000 JPY Research Grant, The Kazuchika Okura Memorial Foundation, 2012, S. Maenosono, 1,000,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2014-2016, S. Maenosono, 3,900,000 JPY 15 Terano Group Shinohara Group Professor Minoru Terano Associate Professor Ken-ichi Shinohara E-mail: [email protected] E-mail: [email protected] Development of Next-generation Highly Functional Polyolefin Materials Single-Molecules Imaging of Polymers Outline: Outline: Polyolefin is still the most important synthetic polymer, which provides full material advantages and allows state-of-the-art technologies. We have explored the potential of polyolefin materials through rational understanding and advanced material design. For providing next-generation materials for the coming sustainable society, we especially focus on the combination of three key technologies: molecularly-tailored olefin polymerization catalysts, polyolefin with exceptional stability over decades, and highly strong & functional nanocomposite materials. We welcome your participation in our group, to become a future leader in the fast-growing and amazing polyolefin society in your country. Polymers are very useful materials that display many excellent properties. However, it is difficult to discuss the correlation between their molecular structures and functions, since these are diverse, dynamic and can be very complex. If the structure and functions of a polymer are directly observed at the molecular level, then the relationships between polymer structures and functions can be clarified. Recently, we have succeeded in the molecular imaging of a longchain branch structure in low-density polyethylene (LDPE) for the first time in the world, using a high-speed (fastscanning) polymerAFM. Furthermore, by synthesis and single-molecules imaging, we have developed a flexible "live" nanomachine with a macromolecular motor utilizing thermal fluctuation. Recent selected publications: Recent selected publications: “Coadsorption model for first-principle description of roles of donors in heterogeneous Ziegler-Natta propylene polymerization”, T. Taniike and M. Terano, J. Catal. 293 (2012) 39. “Vanadium–modified novel bimetallic phillips catalyst with high branching ability for ethylene polymerization”, A. Matta, Y. Zeng, T. Taniike, and M. Terano, Macromol. React. Eng. 6 (2012) 346. “Structure-performance relationship in Ziegler-Natta olefin polymerization with novel core-shell MgO/MgCl2/TiCl4 catalysts”, T. Taniike, P. Chammingkwan, and M. Terano, Catal. Commun. 27 (2012) 13. “Influences of polypropylene grafted to SiO2 nanoparticles on the crystallization behavior and mechanical properties of polypropylene/SiO2 nanocomposites”, M. Umemori, T. Taniike, and M. Terano, Polym. Bull. 68 (2012) 1093. “Kinetic elucidation of comonomer-induced chemical and physical activation in heterogeneous Ziegler-Natta propylene polymerization”, T. Taniike, B. T. Nguyen, S. Takahashi, T. Q. Vu, M. Ikeya, and M. Terano, J. Polym. Sci. A: Polym. Chem. 49 (2011) 4005. “Origin of broad molecular weight distribution of polyethylene produced by Phillips-type silica-supported chromium catalyst”, K. Tonosaki, T. Taniike, and M. Terano, J. Mol. Catal. A: Chem. 340 (2011) 33. K. Shinohara, PCT/JP2013/ 84818 (2014). “Structural Analysis of Polymer Chains by Scanning Probe Microscope”, K. Shinohara, New Development of Surface Treatments for Polymers pp 115-124, CMC Publishing (Tokyo, Japan), ISBN-978-4-7813-0595-0 (2012). “High-Speed Scanning Probe Microscope”, K. Shinohara, JP-A-2012-032389 (2012). “Single-Molecule Imaging of Photodegradation Reaction in a Chiral Helical π-Conjugated Polymer Chain”, K. Shinohara, N. Kodera, T. Oohashi, J. Polym. Sci. Part A: Polym. Chem. 48, 4103–4107 (2010). “Single-Molecule Imaging of a Micro-Brownian Motion of a Chiral Helical π-Conjugated Polymer as a Molecular Spring Driven by Thermal Fluctuations”, K. Shinohara, N. Kodera, T. Ando, Chem. Lett. 38, 690-691 (2009). Recent research funds Recent research funds Dutch Polymer Institute Research Proposals on Polyolefins, 2012-2016, M. Terano, T. Taniike, 300,000 EUR Grant-in-Aid for Young Scientists (B), MEXT, 2012-2013, T. Taniike, 4,290,000 JPY Dutch Polymer Institute Research Proposals on Polyolefins, 2009-2012, M. Terano, T. Taniike, 276,000 EUR Collaboration projects with leading chemical companies (Japan Polychem, Mitsui Chemical, Samsung-Total Petrochemicals, Sumitomo chemicals, Toho Titanium, etc.) Grant-in-Aid for challenging Exploratory Research, MEXT, 2013-2014, “Single-Molecules Imaging of a Movement of a Short Chain along a Long Polymer Chain”, K. Shinohara, 4,160,000 JPY. The System Development Program for Advanced Measurement and Analysis (SENTAN) from the Japan Science and Technology Agency (JST), 2004-2009, “Development of 3-D High Resolution Microscope for Dynamic Structural Analysis of Bio-molecules”, K. Shinohara, 51,100,000 JPY. 16 Yamaguchi Group Kaneko Group Professor Masayuki Yamaguchi Assistant Professor Shogo Nobukawa Associate Professor Tatsuo Kaneko Research Lecturer Seiji Tateyama E-mail: [email protected] E-mail: [email protected] Design of Advanced Polymeric Materials by Rheological Approach Biomolecule Materialization Based on Multifunctional Polymers Outline: Outline: Rheology - the new science of deformation and flow for a material showing complicated mechanical responses - is necessary in order to develop advanced polymeric materials. Our laboratory is carrying out material design of functional, high-performance polymers based on the rheological approach to create novel displays, nextgeneration automobile parts, self-repairing polymers, ecofriendly materials including biomass-based plastics, and so on. Moreover, innovative polymer processing is also studied with our industrial partners, considering trouble-shooting of actual processing operations. Carbon in the earth's atmosphere is stored by photosynthetic activity and stocked as biomass molecules. In Kaneko laboratory, biomass molecules are used to develop environmentally-fiendly materials using cutting-edge science. In particular, we focus on aromatic molecules with a lot of functions mediated by π-electrons, and induce high-performance in polymeric materials. By this strategy, we have developed environmentally-friendly materials with the highest heat-resistance and mechanical strength from biomass molecules. Photofunctionality, liquid crystallinity, and water-related properties in these materials are also our research targets. Recent selected publications: Recent selected publications: “Wavelength Dispersion of Orientation Birefringence for Cellulose Esters Containing Tricresyl Phosphate”, A. M. Mohd Edeerozey, M. Tsuji, Y. Shiroyama, M. Yamaguchi, Macromolecules, 44 (10), 3942-3949 (2011). “Autonomic Healing and Welding by Interdiffusion of Dangling Chains in Weak Gel”, M. Yamaguchi, R. Maeda, R. Kobayashi, T. Wada, S. Ono, S. Nobukawa, Polymer International, 61 (1) 9-16 (2012). “Effect of Thermal Modification on Rheological Properties of Polyethylene Blends”, M. Siriprumpoonthum, S. Nobukawa, Y. Satoh, H. Sasaki, M. Yamaguchi, J. Rheology, 58 (2), 449-466 (2014). “Extraordinary wavelength dispersion of birefringence in cellulose triacetate film with anisotropic nanopores”, S. Nobukawa, H. Shimada, Y. Aoki, A. Miyagawa, V. A. Doan, H. Yoshimura, Y. Tachikawa, M. Yamaguchi, Polymer, 55 (15), 3247-3253 (2014). “Crystallization Behavior and Dynamic Mechanical Properties of Poly(L-Lactic Acid) with Poly(Ethylene Glycol) Terminated by Benzoate”, T. Huang, M. Miura, S. Nobukawa, M. Yamaguchi, J. Polym. Environment, 22 (2), 183-189 (2014). “Bio-based polyimides from 4-aminocinnamic acid photodimer”, P. Suvannasara, S. Tateyama, A. Miyasato, K. Matsumura, T. Shimoda, N. Takaya, T. Kaneko, et al. Macromolecules, 47 (2014) 1586. “ Ionic state and chain conformation for aqueous solutions of supergiant cyanobacterial polysaccharide”, T. Mitsumata, T. Miura, N. Takahashi, M. Kawai, M. Okajima, and T. Kaneko, Phys. Rev. E, 87 (2013) 042607. “Hyperbranching Polycoumarates with Photofunctional Multiple Shape-Memory”, S. Wang, D. Kaneko, M. Okajima, K. Yasaki, S. Tateyama, and T. Kaneko, Angew. Chem. Int. Ed. 52 (2013) 11143. “Hydrotalcites catalyze the acidolysis polymerization of phenolic acid to create highly heat-resistant bioplastics”, M. Chauzar, S. Tateyama, K. Ebitani, T. Kaneko, et al. Adv. Funct. Mater. 22 (2012) 3438. “Environmentally-Degradable, High-performance Plastics from Phenolic Phytomonomers”, T. Kaneko, et al. Nature Mater. 5 (2006) 966. Recent research funds Recent research funds JST, Regional Research and Development Resources Utilization Program, 2008-2012, Material design of extraordinary wavelength dispersion film, M. Yamaguchi, S. Nobukawa, 169,990,000 JPY Grant-in-Aid for Scientific Research (B), 2010-2013, Localization of carbon nanotube in a polymeric multi-components system, M. Yamaguchi, 11,500,000 JPY Research Grant from Suzuki Foundation, 2010-2012, M. Yamaguchi, 9,300,000 JPY Advanced Low Carbon Technology Research and Development Program (ALCA), JST Strategic Basic Research Program, 2011-2015, T. Kaneko, 300,000,000 JPY Core Research for Evolutionary Science and Technology (CREST), JST Strategic Basic Research Program, 2013-2018, T. Kaneko, 100,000,000 JPY Grant for Industrial Technology Research, NEDO, 2007-2011, T. Kaneko, 65,000,000 JPY Creation of Regional Innovation Science and Technology Incubation Program in Advanced Regions “Practical Application Research”, JST, 2007-2010, T. Kaneko, 72,000,000 JPY 17 Matsumura Group Taniike Group Associate Professor Kazuaki Matsumura Associate Professor Toshiaki Taniike E-mail: [email protected] E-mail: [email protected] Functional Polymeric Biomaterials for Controlling the Functions of Living Systems Advanced Material Design based on Synergetic Exploration, Learning, and Prediction Outline: Outline: The creation of functional polymers is a widely-studied process for applications in biomaterials and tissue engineering materials. Polyampholytes are polymers that have both positive and negative ions in 1 molecule. Our results have revealed that several kinds of polyampholytes have a cryoprotective effect on cells in solution. We will investigate and develop membrane-protective materials that can control cell functions, by clarifying the mechanisms underlying such cryoprotective effects. We also perform basic and applied research on materials well-matched to living systems; this research is aimed toward the regeneration of functions in tissue engineering. Under urgent pressure for a shift to a sustainable society, conceptual and technical maturation of materials science makes it increasingly difficult to find truly new materials. The mission of Taniike Laboratory is to renovate materials science by establishing a new material design scheme based on synergetic combination of high-throughput experimentation (exploration), multivariate analysis for quantitative clarification of structure-property relationships (learning), and quantum chemical calculation (prediction). We deliver twofold outputs: serendipitous catalytic and polymeric materials in response to the needs of the times, and next-generation material scientists who have become familiar with this acquire the unique material design scheme. Recent selected publications: Recent selected publications: “Self-degradation of tissue adhesive based on oxidized dextran and poly-L-lysine”, K. Matsumura, N. Nakajima, H. Sugai, and SH. Hyon, Carbohydr. Polym. (2014) in press. “Protein cytoplasmic delivery using polyampholyte nanoparticles and freeze concentration”, S. Ahmed, F. Hayashi, T. Nagashima, and K. Matsumura, Biomaterials 36 (2014) 6508. “Hydrogelation of dextran-based polyampholytes with cryoprotective properties via click chemistry”, M. Jain, R. Rajan, SH. Hyon, and K. Matsumura, Biomater. Sci. 2 (2014) 308. “Cryoprotective properties of completely synthetic polyampholytes via reversible addition-fragmentation chain transfer (RAFT) polymerization and the effects of hydrophobicity”, R. Rajan, M. Jain, and K. Matsumura, J. Biomater. Sci. Polym. Ed. 24 (2013) 1767. “Long-term cryopreservation of human mesenchymal stem cells using carboxylated poly-L-lysine without the addition of proteins or dimethyl sulfoxide”, K. Matsumura, F. Hayashi, T. Nagashima, and SH. Hyon, J. Biomater. Sci. Polym. Ed. 24 (2013) 1484. “Sol-gel synthesis of nano-sized silica in confined amorphous space of polypropylene: impact of nano-level structures of silica on physical properties of resultant nanocomposites”, K. Takeuchi, M. Terano, and T. Taniike, Polymer 55 (2014) 1940. “Polypropylene-grafted nanoparticles as a promising strategy for boosting physical properties of polypropylene-based nanocomposites”, T. Taniike, M. Toyonaga, and M. Terano, Polymer 55 (2014) 1012. “Multilateral characterization for industrial Ziegler–Natta catalysts toward elucidation of structure–performance relationship”, T. Taniike, T. Funako, and M. Terano, J. Catal. 311 (2014) 33. “The use of donors to increase the isotacticity of polypropylene”, T. Taniike, and M. Terano, Adv. Polym. Sci. 257 (2013) 81. “Coadsorption model for first-principle description of roles of donors in heterogeneous Ziegler-Natta propylene polymerization”, T. Taniike, and M. Terano, J. Catal. 293 (2012) 39. Recent research funds Recent research funds Grant-in-Aid for Young Scientists (B), MEXT, 2013-2014, K. Matsumura, 3,120,000 JPY Grant from Collaborative Research Project organized by the Interuniversity Bio-Backup Project (IBBP), 2013-2014, K. Matsumura, 5,250,000 JPY Grant from the Canon Foundation, 2012-2013, K. Matsumura, 13,000,000 JPY A-STEP Feasibility Study, JST 2011, K. Matsumura, 1,700,000 JPY Grant-in-Aid for Young Scientists (B), 2012-2013, T Taniike, 4,290,000 JPY Grant-in-Aid for Young Scientists (B), 2009-2011, T Taniike, 3,120,000 JPY Dutch Polymer Institute Research Proposals on Polyolefins, 2012-2016, T Taniike et al., 300,000 EUR Dutch Polymer Institute Research Proposals on Polyolefins, 2009-2012, T Taniike et al., 276,000 EUR *Collaboration with companies: IRPC Public, Japan Polychem, Sumitomo Chemials, etc. 18 Takamura Group Hiratsuka Group Professor Yuzuru Takamura Associate Professor Yuichi Hiratsuka E-mail: [email protected] E-mail: [email protected] Microfluidic Devices and Sensors for Biochemical and Medical Applications Micro-Mechanical Devices Powered by Motor Proteins Outline: Outline: We are studying next generation biochip techniques for various biomedical and environmental applications, employing semiconductor technology, nanomaterials / biomolecules, micro / nanofluidics, and lab-on-a-chip techniques. Our interests extend to a wide range of topics in the fusion of nanotechnology and biotechnology, to understanding of phenomena at the nano & micro scale, and to practical applications such as highly-sensitive point-of-care biosensors, manipulation of liquids on chip, analysis of single cells and single molecules, LEP-AES ultra-compact elemental analyzer, and various bio/chemical processing units. Living organisms have developed diverse functions through evolution over a long period of time. Some functions are related to mobility, including muscle contraction, bacteria' s swimming and cell division. Nanometer proteins called motor proteins are integrated into motion assemblies with dimensions ranging from the micrometer-scale (bacteria) to the meter-scale (muscle). A motor protein is a molecular machine that converts chemical energy into dynamic force with great efficiency. This is an excellent property that conventional artificial motors do not have. In our laboratory, we are developing biohybrid micromachines using organic motors and micro-fabrication technology. Recent selected publications: Recent selected publications: “High sensitive elemental analysis for Cd and Pb by liquid electrode plasma atomic emission spectrometry with quartz glass chip and sample flow”, A. Kitano, A. Iiduka, T. Yamamoto, Y. Ukita, E. Tamiya, and Y. Takamura, Anal. Chem. 83 (2011) 9424. “Trapping probability analysis of a DNA trap using electric and hydrodrag force fields in tapered microchanels”, Y. Tomizawa, E. Tamiya, and Y. Takamura, Phys. Rev. E 79 (2009) 051902. “Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors,” K. Maehashi, T. Katsura, K. Matsumoto, K. Kerman, Y. Takamura, and E. Tamiya, Anal. Chem. 79 (2007) 782. “Separation of long DNA molecules by quartz nanopillar chips under a direct current electric field”, N. Kaji, Y. Tezuka, Y. Takamura, M. Ueda, T. Nishimoto, H. Nakanishi, Y. Horiike, Y. Baba, Anal. Chem. 76 (2004) 15. “Low-voltage electroosmosis pump for stand-alone microfluidics devices”, Y. Takamura, H. Onoda, H. Inokuchi, S. Adachi, A. Oki, and Y. Horiike, Electrophoresis 24 (2003) 185. "Self-organized optical device driven by motor proteins", Susumu Aoyama, Masahiko Shimoike, and Yuichi Hiratsuka, Proc. Nati. Acad. Sci. vol. 110 no. 41, 16408-16413 (2013) “Utilization of myosin and actin bundles for the transport of molecular cargo “, H. Takatsuki, K. M. Rice, S. Asano, B. S. Day, M. Hino, K. Oiwa, R. Ishikawa, Y. Hiratsuka, T. Q. P. Uyeda, K. Kohama, and E. R. Blough, Small 6 (2010) 452. “Loading and unloading of molecular cargo by DNA-conjugated microtubule” , S. Taira, Y. Z. Du, Y. Hiratsuka, T. Q. P. Uyeda, N. Yumoto, and M. Kodaka, Biotech. Bioeng. 99 (2008) 734. “Bacteria powered microrotary motor “, Y. Hiratsuka, Bionics 26 (2007) 68. “Three approaches to assembling nano-bio-machines using molecular motors “, Y. Hiratsuka, T. Kamei, N. Yumoto, and T. Q. P. Uyeda, NanoBiotechnol. 2 (2006) 101. “Toward a microrotary motor driven by motor Proteins “, Y. Hiratsuka and S. Takeuchi, MEMS2007 (2007) 695. “Micro-rotary motor powered by bacteria. “, Y. Hiratsuaka, M. Miyata, T. Tada and T. Q. P. Uyeda, Proc. Nat. Acad. Sci. 103 (2006) 13618. Recent research funds Recent research funds Knowledge Cluster Initiative, MEXT, 2007-2013, Y. Takamura, 66,500,000 JPY A-STEP Feasibility Study, JST, 2009-2010, Y. Takamura, 5,000,000 JPY Grant-in-Aid for Scientific Research (B), MEXT, 2007-2011, Y. Takamura, 14,400,000 JPY Grant-in-Aid for Scientific Research in Priority Areas, MEXT, 2007-2009, Y. Takamura, 4,600,000 JPY Strategic Support Industry Project for Key Tech, METI, 2011-2011, Y. Takamura, 3,355,000 JPY PRESTO, JST, 2003-2007, Y. Takamura, 41,950,000 JPY Dev. Univ. Venture, JST, 2004-2007, Y. Takamura, 108,550,000JPY PRESTO, JST, 2006-2010, Y. Hiratsuka, 40,000,000 JPY Grant-in-Aid for Scientific Research, MEXT, 2008-2010, Y. Hiratsuka, 3,500,000 JPY Grant-in-Aid for Scientific Research(B), MEXT, 2010-2013, Y. Hiratsuka, 14,400,000 JPY Grant-in-Aid for Scientific Research, MEXT, 2012-2014, Y. Hiratsuka, 4,050,000 JPY Grant-in-Aid for Scientific Research on Innovation Area, 2012.4-2018.3, “Molecular robotics”, Yuichi Hiratsuka, 24,000,000 JPY 19 Hohsaka Group Fujimoto Group Professor Takahiro Hohsaka Assistant Professor Takayoshi Watanabe Professor Kenzo Fujimoto Assistant Professor Takashi Sakamoto E-mail: [email protected] E-mail: [email protected] Protein Engineering with Nonnatural Amino Acids Challenge for Bio-science and Bio-innovation from Chemistry Outline: Outline: Proteins are made up of only 20 types of amino acids. Incorporation of nonnatural amino acids into proteins greatly expands the possibilities of protein engineering. We have developed a novel technology allowing us to introduce nonnatural amino acids into specific positions in proteins using expanded genetic codes such as four-base codons and amber stop codon. Applying this technology, we are developing nonnatural proteins exhibiting various artificial functions as well as novel tools for analysis of protein structures and functions. In addition, industrial applications of this technology are now in development through collaboration with bio-venture companies. Our laboratory has been involved in the development of systems to facilitate the integration of chemistry, biology and physics. On of our research achievement is the development of an optical control method for linking and cutting DNA chains, which is quite different from conventional DNA control using enzymes. Based on our optical control method, we successfully developed a DNA computing system that conducts logic operations by binalization if a specific DNA is present. We are working toward applying the system for quick and precise prediction of susceptibility to certain disease caused by multiple abnormal DNA. Recent selected publications: Recent selected publications: “Incorporation of fluorescent nonnatural amino acid into sialic acid-binding lectin for fluorescence detection of ligand-binding”, Y. Ito, T. Hohsaka, Bull. Chem. Soc. Jpn., 86, 729-735 (2013). “Synthesis of novel BRET/FRET protein probes containing light-emitting proteins and fluorescent nonnatural amino acids”, A. Yamaguchi, T. Hohsaka, Bull. Chem. Soc. Jpn., 85, 576-583 (2012). “Amber codon-mediated expanded saturation mutagenesis of proteins using a cell-free translation system”, N. Shozen, T. Watanabe, T. Hohsaka, J. Biosci. Bioeng., 113, 704–709 (2012). “’Quenchbodies’: Quench-based antibody probes that show antigen-dependent fluorescence”, R. Abe, H. Ohashi, I. Iijima, M. Ihara, H. Takagi, T. Hohsaka, H. Ueda, J. Am. Chem. Soc., 133, 17386-17394 (2011). “Position-specific incorporation of fluorescent non-natural amino acids into maltose-binding protein for detection of ligand binding by FRET and fluorescence quenching”, I. Iijima, T. Hohsaka, ChemBioChem, 10, 999-1006 (2009). "Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides", Takashi Sakamoto, Atsuo Shigeno, Yuichi Ohtaki and Kenzo Fujimoto, Biomaterials Science, 2, 1154–1157 (2014). “Details of the ultra-fast DNA photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside; Cis-trans isomeric effect and the application for SNP based genotyping”, K. Fujimoto, A. Yamada, Y. Yoshimura, T. Tsukaguchi and T. Sakamoto, J. Am. Chem. Soc. 135(43), 16161-16167 (2013). “Quick Regulation of mRNA Functions by a Few Seconds of Photoirradiation”, A. Shigeno, T. Sakamoto, Y. Yoshinaga and K. Fujimoto, Organic & Biomolecular Chemistry 10(38), 7820-7825 (2012). “Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole”, K. Fujimoto, K. H. Hiratsuka, T. Sakamoto, and Y. Yoshimura, Molecular BioSystems 8, 491-494 (2012). “Site-Specific Photochemical RNA Editing”, K. Fujimoto, T. Sakamoto, K. H. Hiratsuka and Y. Yoshimura, Chem. Commun. 46, 7545-7549 (2010). Recent research funds Recent research funds Grant-in-Aid for Scientific Research on Innovative Areas, 2013-2017, Development of chemically expanded biomolecular systems with dynamic ordering function, Takahiro Hohsaka, 93,340,000 JPY Grant-in-Aid for Scientific Research on Innovative Areas, 2008-2012, Study of protein fluctuations by introducing nonnatural amino acids, Takahiro Hohsaka, 93,080,000 JPY Grant-in-Aid for Scientific Research (B), 2007-2009, FRET analysis of protein conformational changes through position-specific incorporation of fluorescent amino acids, Takahiro Hohsaka, 18,590,000 JPY Grant-in-Aid for Scientific Research (B), MEXT, 2014-2017, K. Fujimoto, 16,500,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2014-2016, K. Fujimoto, 4,250,000 JPY Grant-in-Aid for Scientific Research on Innovative Areas, MEXT, 2012-2016 “Development of Molecular Robots equipped with sensors and intelligence” 、K. Fujimoto、44,000,000 JPY Grant-in-Aid for Scientific Research (B), MEXT, 2011-2014, K. Fujimoto, 15,500,000 JPY Grant-in-Aid for Challenging Exploratory Research, MEXT, 2012-2014, K. Fujimoto, 4,160,000 JPY 20 Takagi Group Hamada Group Professor Masahiro Takagi Assistant Professor Naofumi Shimokawa Associate Professor Tsutomu Hamada Assistant Professor Ken Nagai E-mail: [email protected] E-mail: [email protected] Membrane Dynamics and Cellular Signal Transduction Soft Matter Physics Approach to Cell-Mimicking Systems Outline: Outline: It is important to understand the physical mechanisms that govern the dynamic motions and properties of cell plasma membranes. Liposomes are self-assembled colloidal particles that occur naturally, and they can be prepared artificially. Liposomes resemble cell membranes in their structure and composition. Conventional liposomes are very small (<100 nm) but we are using giant vesicles with a diameter on the order of 10 μm, which are large enough to allow direct and real-time microscopic observations of membrane dynamics at the level of single vesicles. We are performing many experimental studies using both giant vesicles and actual living cells. We use a soft matter physics approach to cell-mimicking systems so that we can understand the physical principles of biological systems. Living cells are a form of self-assembled soft matter. Lipid bilayer membranes are essential components of living organisms. We i) construct artificial lipid vesicles which produce cellular dynamics, such as endocytosis and autophagy, ii) elucidate the association of biological and nonbiological nano-materials on membrane surfaces, and iii) conduct quantitative analyses based on condensed soft matter physics. Recent selected publications: Recent selected publications: “The effect of oxysterols on the interaction of Alzheimer's amyloid beta with model membranes.” , H. T. T. Phan, T. Hata, M. Morita, T. Yoda, T. Hamada, M. C. Vestergaard, M. Takagi, BBA-Biomembrane, 1828,2487-2495 (2013). “Ion permeation by a folded multiblock amphiphilic oligomer achieved by hierarchical construction of self-assembled nanopores.” , T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K. Tabata, H. Noji, K. Kinbara, J. Am. Chem. Soc., 134, 19788–19794 (2012). “Size-dependent partitioning of nano/micro-particles mediated by membrane lateral heterogeneity.” , T. Hamada, M. Morita, M. Miyakawa, R. Sugimoto, M. Vestergaard, M. Takagi, J. Am. Chem. Soc.,134,13990−13996 (2012). “Photochemical control of membrane raft organization.” , T. Hamada, R. Sugimoto, T. Nagasaki, M. Takagi, Soft Matter, 7, 220-224 (2011). “Membrane disk and sphere: controllable mesoscopic structures for the capture and release of a targeted object” , T. Hamada, R. Sugimoto, M. Vestergaard, T. Nagasaki, M. Takagi, J. Am. Chem. Soc., 132, 10528-10532 (2010). "Dynamical formation of lipid bilayer vesicles from lipid-coated droplets across a planar monolayer at an oil/water interface" H. Ito, T. Yamanaka, S. Kato, T. Hamada, M. Takagi, M. Ichikawa, K. Yoshikawa, Soft Matter, 9, 9539-9547 (2013). “Size-dependent partitioning of nano/micro-particles mediated by membrane lateral heterogeneity” T. Hamada, M. Morita, M. Miyakawa, R. Sugimoto, M. C. Vestergaard, M. Takagi, J. Am. Chem. Soc., 134, 13990−13996 (2012). “Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells” T. Hamada, K. Yoshikawa, Materials, 5, 2292-2305 (2012). "Lateral phase separation in tense membranes" T. Hamada, Y. Kishimoto, T. Nagasaki, M. Takagi, Soft Matter, 7, 9061-9068 (2011). “Membrane disk and sphere: controllable mesoscopic structures for the capture and release of a targeted object” T. Hamada, R. Sugimoto, M. Vestergaard, T. Nagasaki, M. Takagi, J. Am. Chem. Soc., 132, 10528-10532 (2010). "Rhythmic pore dynamics in a shrinking lipid vesicle" T. Hamada, Y. Hirabayashi, T. Ohta, M. Takagi, Phys. Rev. E Stat. Nonlin. Soft Matter Phys., 80, 051921 (2009). Recent research funds Recent research funds A Grant-in-Aid for Scientific Research (B) 2014-2016 “Analyses, design and control of 2D and 3D dynamics of cell-mimetic membrane.” Masahiro Takagi 14,130,000 JPY A Grant-in-Aid for Challenging Exploratory Research 2013-2014 “Alternatives to animal testing based on membrane dynamics.” Masahiro Takagi 3,900,000 JPY A Grant-in-Aid for Scientific Research (B) 2011-2013 “Analysis and control of membrane raft dynamics.” Masahiro Takagi 13,700,000 JPY Grant-in-aid for Scientific Research Innovative Areas, MEXT, 2014-2015, T. Hamada, 5,200,000 JPY Grant-in-aid for Scientific Research Innovative Areas, MEXT, 2013-2014, T. Hamada, 4,900,000 JPY Grant-in-aid for Scientific Research Innovative Areas, MEXT, 2012-2013, T. Hamada, 5,700,000 JPY Grant-in-aid for Scientific Research Young Scientist (B), JSPS, 2011-2013, T. Hamada, 3,300,000 JPY Grant-in-aid for Scientific Research Specific Area Research, MEXT, 2009-2010, T. Hamada, 6,600,000 JPY 21 Tsukahara Group Ohki Group Professor Toshifumi Tsukahara Assistant Professor Hitoshi Suzuki Professor Shinya Ohki Assistant Professor Yoshitaka Umetsu E-mail: [email protected] E-mail: [email protected] Development of Innovative Medical Technology Based on RNA Research NMR-based Structural and Functional Biology: From Basics to Applications of Proteins Outline: Outline: All living organisms including human beings have "genes" , which are basically composed of the same compounds. Gene expressions are indicated by quantities and species of RNA molecules, which are informational materials. We are working on RNA research toward biomedical applications. mRNAs provide the blueprints of proteins, the functional molecules, in a cell. Therefore, we can understand the physical or pathological state in vivo through the information of mRNA molecules. Our laboratory aims to clarify the features of RNAs, including their expression profiles and mechanisms of alternative splicing. We hope this research will contribute to the development of novel genetic tests and nucleic acid drugs. Proteins are functional materials to regulate numerous biological events in living bodies. Studying their structures and functions is essential to understand what life is. In our group, an 800MHz-NMR machine is employed to explore protein conformations, dynamics, and interactions. Recent research interest is focused on plant science, especially on proteins related to photosynthesis. We are also interested in developing new methods for NMR sample preparation. Our results will provide key information for a deeper understanding of functional mechanisms of biomolecules as well as clarify ways to design new drugs and chemicals to control various biological signaling pathways. Recent selected publications: “A View of Pre-mRNA Splicing from RNase R Resistant RNAs“. H. Suzuki and T. Tsukahara, Int. J. Mol. Sci. 15, (2014), 9331-9342; doi:10.3390/ijms15069331 “Nested introns in an intron: Evidence of multi-step splicing of a large intron in the human dystrophin pre-mRNA” . H. Suzukia, T. Kameyama, K. Ohe, T. Tsukahara, A. Mayeda, FEBS Letters. (2013) doi: 10.1016/j.febslet.2013.01.057 “Alternative splicing produces structural and functional changes in CUGBP2” , H. Suzuki, M. Takeuchi, A. Sugiyama, A. H. M. K. Alam, T. L. Vu, Y. Sekiyama, C. H. Dam, S. Ohki, and T. Tsukahara, BMC Biochem. 13 (2012) 6. “Functional gene expression analysis of tissue-specific isoforms of Mef2c” , Y. Sekiyama, H. Suzuki, and T. Tsukahara, Cell. Mol. Neurobiol. 32 (2012) 129. “Comprehensive analysis of alternative splicing and functionality in neuronal differentiation of P19 cells” , H. Suzuki, K. Osaki, K. Sano, A. H. M. K. Alam, Y. Nakamura, Y. Ishigaki, K. Kawahara, and T. Tsukahara, PLoS ONE 6 (2011) e16880. Recent selected publications: “Central Cell-Derived Peptides Regulate Early Embryo Patterning in Flowering Plants” L.M. Costa, E. Marshall, M. Teshaye, K.A.T. Silverstein, M. Mori, Y. Umetsu, S.L. Otterbach, R. Papareddy, H.G. Dickinson, K. Boutiller, K.A. VandenBosch, S. Ohki and J.F. Gutierrez-Marcos. Science 344 (2014) 168-172. “Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function” S. Zhu, S. Peigneur, B. Gao, Y. Umetsu, S. Ohki and J. Tytgat. Mol. Biol. Evol. 31 (2014) 546-559. “Evolutionary Relationship and Structural Characterization of the EPF/EPFL Gene Family” N. Takata, K. Yokota, S. Ohki, M. Mori, T. Taniguchi and M. Kurita. PLOS ONE (2013) DOI:10.1371/journal.pone.0065183. “Structural Characterization of a Trapped Folding Intermediate of Pyrrolidone Carboxyl Peptidase from a Hyperthermophile” M. Mizuguchi, M. Takeuchi, S. Ohki, Y. Nabeshima, T. Kouno, T. Aizawa, M. Demura, K. Kawano and K. Yutani. Biochemistry 51 (2012) 6089-6096. “The NMR Structure of Stomagen Reveals the Basis of Stomatal Density Regulation by Plant Peptide Hormones” S. Ohki, M. Takeuchi and M. Mori. Nat. Commun. 2 (2011) 512. Recent research funds Recent research funds Grant-in-Aid for Neurological and Psychiatric Diseases, MHLW, 2009-2014, H. Suzuki, 10,300,000 JPY Grant-in-Aid for Scientific Research (B), JSPS, 2013-2015, T. Tsukahara, 14,200,000 JPY Grant-in-Aid for Exploratory Research, JSPS, 2014-2015, T. Tsukahara, 3,400,000 JPY Grant-in-Aid for Scientific Research (C), MEXT, 2008-2011, S. Ohki, 4,200,000 JPY Seeds Research, JST Innovation Plaza Ishikawa, 2009, S. Ohki, 2,000,000 JPY SENTAN, JST, 2008-2012, S. Ohki, 45,100,000 JPY Grant-in-Aid for Scientific Research (C), MEXT, 2013-2016, S. Ohki, 4,500,000 JPY 22 Tsutsui Group Associate Professor Hidekazu Tsutsui E-mail: [email protected] Molecular Sensors For Bioelectrical Signals Outline: Not only the artificial devices but living organisms also use electric signals to process information outside and within. Seeking to obtain insights for principles underlying the signal processing, we investigate molecular sensors for bioelectrical signals. Our research focus on the three main topics: 1) Electrophysiological and spectroscopic approaches to reveal molecular mechanisms of natural membrane protein sensors. 2) Fabrication of artificial molecular sensors and nano-scale devices for the detection of spatiotemporal regulations of cellular electrical activities. 3) Biomedical applications of the sensor technologies, including the development of an efficient drug screen platform. Recent selected publications: “Rapid evaluation of a protein-based voltage probe using a field-induced membrane potential change. “, Tsutsui, H., Y. Jinno, A. Tomita, Y. Okamura, Biochimica et Biophysica Acta – Biomembranes, in press (2014). “Improved detection of electrical activity with a voltage probe based on a voltagesensing phosphatase.” , Tsutsui, H., Y. Jinno, A. Tomita, Y. Niino, Y. Yamada, K. Mikoshiba, A. Miyawaki, Y. Okamura, J. Physiol., 591, 4427- 4437 (2013). “Optically Detected Structural Change in the N-Terminal Region of the VoltageSensor Domain.” , Tsutsui, H., Y. Jinno, A. Tomita, Y. Okamura, Biophys. J., 105, 108-15 (2013). “Optical action potential screening on adult ventricular myocytes as an alternative QT-screen.” , Tian, Q., M. Oberhofer, S. Ruppenthal, A. Scholz, V. Buschmann, H. Tsutsui, A. Miyawaki, A. Zeug, P. Lipp, and L. Kaestner, Cell. Physiol. Biochem., 27, 281-90 (2011). “Visualizing voltage dynam- ics in zebrafish heart.” , Tsutsui, H., S. Higashijima, A. Miyawaki, and Y. Okamura, J. Physiol. 588, 2017-21 (2010). “The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins.” , Tsutsui, H., H. Shimizu, H. Mizuno, N. Nukina, T. Furuta, and A. Miyawaki, Chem. Biol, 16, 1140-1147 (2009). Recent research funds JST PRESTO, 2009-2014, Next generation technology for spatiotemporal measurement of membrane electrical signals, Hidekazu Tsutsui, 76,100,000 JPY JSPS, Grant-in-Aid for Scientific Research on Innovative Areas, 2011-2012 , Detection and control of spatiotemporal dynamics of cell membrane voltage, Hidekazu Tsutsui, 6,890,000 JPY JSPS, Grant-in-Aid for Scientific Research on Innovative Areas, 2009-2010 , Precise functional mapping of cellular electrical activities in vivo, Hidekazu Tsutsui, 6,500,000 JPY 23 Center for Nano Materials and Technology The Center for Nano Materials and Technology (CNMT) started in 2002 as a renewal of the former Center for New Materials, and is devoted to advanced research and education on nanotechnology. The Center promotes the Nanotechnology Education Program. It also supports joint projects in basic research and development of nanotechnology. Those projects are driven by domestic as well as foreign research groups at the highest level, for which the Center provides its state-of-the-art facilities. Research Facilities and Instruments The Center has special facilities and a variety of state-of-the-art instruments dedicated to basic research and development of nanomaterials. The special facilities include clean rooms and a helium gas liquefaction system. Research instruments include an 800 MHz NMR, mass spectrometers, SQUIDs, STMs, TEMs, SEMs, an RBS system and MBE systems. Director Goro Mizutani Professor Nano Material Technology Program Academic Field Nonlinear optical spectroscopy and microscopy Since 2002, the Center has been promoting a systematic education program, the Nano Material Technology Program, to provide students and company engineers with a wide variety of knowledge and techniques regarding current advanced nanoscience and nanotechnology. This program includes lectures and training programs on nano-device fabrication, nano-biotechnology and nano-molecular analysis. 800 MHz NMR Scanning Transmission Electron Microscope Green Device Research Center The objective of the center is creation of innovative technologies for the realization of a sustainable society. Newly-developed nano-size printing using unique solution materials will make sustainability possible. Outline and Objective The Green Device Research Center (GD-RC) was established to create new technologies which embody FACTOR 10 by concentrating state-of-the-art technologies and science assets possessed by the laboratories in the School of Materials Science in JAIST. FACTOR 10 is a challenging target, to develop a sustainable society, by enhancing properties and efficiencies of products, processes, etcetera, more than 10 times compared to conventional technologies. Director Tatsuya Shimoda Professor Academic Field Magnetic Material, Electronics Devices 24 Research and Development Activities For sustainability, so-called printable electronics technology is very attractive to explore. Creating new printing technology and researching novel solution materials are essential aspects of our activities. As for printing technology, we have just succeeded in creating a new process named "nano-Rheology Printing (n-RP)" method, which uses metal-oxide materials in gel form for printing tiny devices as small as tens of nano-meters. Now, we have already started to develop transistor arrays for an active matrix back-plane of a display. Other n-RP related research programs, such as MEMS devices, optical parts and stacked capacitors, will commence soon. Satoshi Inoue Jinwang Li Manish Biyani Research Professor Research Associate Professor Research Associate Professor Research Center for Highly Environmental and Recyclable Polymers To cope with global warming and environmental pollution, polymer technologies will play a great role in developing a sustainable society. This center aims to develop technologies for a new generation of environmentally-friendly and recyclable polymers, and also to facilitate their industrialization, through active collaboration with domestic and foreign industrial and research groups. Research Projects Underway This center is mainly composed of six research groups that are actively conducting research and education in their respective fields. The research activities of this center cover these essential fields, such as 1) catalytic monomer synthesis, 2) polymer synthesis, 3) polymer physics, and 4) functionalization of polymers. Director Masayuki Yamaguchi Professor Academic Field Polymer Rheology, Polymer processing The following research is being carried out at the center. ・Material design of novel eco-friendly polymers based on applied rheology ・Design of nano-structured catalysts for utilization of biomass-derived materials ・Development of high-performance carbon-minus materials using renewable giant macromolecules ・Development of bio-based functional polymers for energy devices. ・Development of functional polymer biomaterials ・Development of novel polymer nanocomposites Research Center for Bio-Architecture The Center was founded in April 2011, aiming at synthesis and organization of innovative artificial biomolecules and at development of artificial biosystems. Synthesis of Artificial Biomolecules and their Organization Director Takahiro Hohsaka Professor Academic Field Extended Genetic Engineering, Biomolecular Engineering Recent progress in life science has revealed detailed mechanisms of biosystems at a molecular level. This progress allows us to investigate "Bio-architecture research" which aims to develop biosystems using biomolecules such as nucleic acids, proteins, and biomembranes. In the School of Materials Science at JAIST, we have achieved creation of artificially-modified nucleic acids, proteins, and membranes showing specific functions. Based on these achievements, the Research Center for Bio-Architecture was founded, aiming at synthesis and organization of innovative artificial biomolecules and at development of artificial biosystems. The center also aims at application of achievements in scientific research to actual medical developments, such as novel therapeutic and diagnostic drugs. Research Center for Simulation Science Development of simulation science and construction of new perspectives Director Teruo Matsuzawa SGI Altix UV1000 This research center aims to develop simulation science and high-level specialists in the field, and construct new perspectives by tightly integrating information science, computational science, and data science. The frontier of simulation science, such as elucidation of complicated phenomena and computer-aided material design, will be established by a close collaboration between computer science such architecture, high performance computing, database, formal theory, and data mining, and computational science focusing on materials and life sciences. The construction of a new paradigm is also pursued by bridging between fundamental theories, such as data mining, data assimilation, and formal theory, and more practical physical and chemical problems. 25 Cutting-edge Facilities The Most Advanced Experimental Equipment JAIST professors and technical staff cooperate to maintain a variety of advanced equipment, which students and researchers are encouraged to use freely in their work. By simply attending a brief course on operating techniques, JAIST researchers (including students) can obtain permission to use the specialized equipment necessary for research and discovery at the frontiers of today’ s technology. That is to say, any student at JAIST has complete access to all of our most advanced equipment, a truly ideal environment for this stage of your career. JAIST has a variety of advanced equipment, listed below, to support research in nano-technology and other fast-growing fields. FT-ICR-MS EPMA FIB Research Infrastructure and Equipment 200kV Scanning Transmission Electron Microscope (STEM) JEM-ARM200F, JEOL 100kV Transmission Electron Microscope (TEM) H-7100 and H-7650, Hitachi 300kV Transmission Electron Microscope (TEM) H-9000NAR, Hitachi Scanning Electron Microscope (SEM) S-4100, S-4500 and S-5200, Hitachi 400MHz Nuclear Magnetic Resonance Spectrometer (NMR) AVANCE III 400, Bruker BioSpin 500MHz Nuclear Magnetic Resonance Spectrometer (NMR) AVANCE III 500, Bruker BioSpin 800MHz Nuclear Magnetic Resonance Spectrometer (NMR) AVANCE III 800, Bruker BioSpin Electron Spin Resonance Spectrometer (ESR) JES-RE3X, JEOL X-ray Diffractometer (XRD) RINT2100, RINT2500 and SmartLab, Rigaku 4-axis X-ray Diffractometer (XRD) RASA-7A, Rigaku Thin Film X-ray Diffractometer (XRD) X’Pert PRO MRD, PANalytical Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR-MS) 26 Solarix-JA, Bruker Daltonics Rutherford Backscattering Spectrometer (RBS) NT-1700H, NHV Corp. X-ray Photoelectron Spectrometer (XPS) AXIS-ULTRA DLD, Shimadzu/Kratos Electron Probe Microanalyzer (EPMA) JXA-8900L, JEOL Raman Spectrometer T64000, HORIBA-JY Physical Property Measurement System: Thermal Transport Option PPMS-TTO, Quantum Design Superconducting Quantum Interference Device Magnetometer(SQUID) MPMS-5T and MPMS-7T, Quantum Design Focused Ion Beam System (FIB) SMI3050, SII NanoTechnology Nuclear Magnetic Resonance Spectrometer: NMR 800MHz Bruker BioSpin, Avance III 800 The NMR (Nuclear Magnetic Resonance) machine detects FID (free induction decay), which is the response to RF (radio frequency) pulses applied to the nuclear spins set in the strong magnetic field. NMR spectra obtained by fourier-transformation of FID data give information about molecular structures and dynamics at atomic resolution. The NMR machine with higher magnetic field can provide better sensitivity and higher resolution. This is one of the ultra-high field NMR machines, on which 1H resonance frequency is 800 MHz, installed at several universities in Japan, and it is a very valuable instrument. The strong magnetic field enables a wide variety of advanced research. JAIST also has other NMR machines which can be used by many professors and students for their own research. (top) Two dimensional NMR (NOESY) spectrum of stomagen. (bottom) 1H-15N HSQC of stomagen, a peptide hormone to increase stomatal density. Shinya Ohki, et al. Nat. Commun. (2011) 2, 51 1 H NMR spectrum focusing on the acetyl groups of poly(DHCA-co-4HCA) Siqian Wang, et al. Ploym. Degrad. Stab. (2011) 96, 2048 27 Cutting-edge Facilities Scanning Transmission Electron Microscope (Atomic Resolution): STEM, JEOL, JEM-ARM200F The TEM is an apparatus used to observe and analyze microstructures of materials. The ARM200F, incorporating a spherical aberration corrector for electron optic system as standard and the maximum level of electrical and mechanical stability, has achieved a scanning transmission image (STEM-HAADF) resolution of 0.08 nm, the highest in the world among commercial transmission electron microscopes. The electron probe, after its aberrations are corrected, features a current density level higher by an order of magnitude than c o n v e n t i o n a l t r a n s m i s s i o n e l e c t ro n microscopes. With this probe finely focused, the ARM200F is capable of atomic level analysis, substantially reducing measurement time and improving throughput. JAIST also has other TEMs which can be used by many professors and students for their own research. TEM image of ([email protected])@Au double shell NPs Dao Thi Ngoc Anh, et al. Appl. Phys. Lett. (2011) 99, 073107 28 EDS element mapping and plots of sulfur counts along the cross section of devices Varun Vohra, et al. J. Phys. Chem. Lett. (2012) 3, 1820 Cleanroom The Center for Nano Materials and Technology includes 6 Cleanrooms, which are equipped with a vertical flow air-filtering system to remove particles. These cleanrooms, located on the 1st floor of the C e n t e r, o f f e r c o n t r o l f u n c t i o n s f o r temperature and humidity as well. Rooms 1-4 are Class 1000, Room 5 is Class 100, and Room 6 is Class 10; only qualified researchers are permitted to enter these rooms, and special protective clothing is available. The slightly higher air pressure in the cleanrooms prevents possible contamination from particles entering the rooms. T h e s e c l e a n ro o m s c o n t a i n v e r s a t i l e equipment for semiconductor process research, to support university research in the fields of microelectronics, electronic m a t e r i a l s , n a n o t e c h n o l o g y, M E M S , lithography, optics, and other areas requiring a particle-free environment. The special lighting in the rooms is suited for precise work with sensitive materials, and large windows provide a comfortable, safe, and convenient working environment. Electron distribution and scattering in InAs films on low-k flexible substrates Cong Thanh Nguyen, et al. Appl. Phys. Lett. (2012) 100, 232103 Tatsuya Shimoda, Japanese Patent Application 2009-112455. 29 Features of the Educational System Education Programs for a Variety of Study Objectives In the rapidly evolving global work environment, JAIST offers a flexible education system so that you can achieve your career goals. JAIST offers an educational program that can be tailored to fit your personal goals and objectives, allowing a personalized education that will completely prepare you for your chosen career. JAIST also offers a flexible registration system in support of students entering from the workforce, giving true flexibility to your research and studies. 5 years D Program S Type 5D Program E Type 3D Program M Program M Program S Type 5D (5-year Doctoral) program is designed for those who intend to pursue a doctoral degree from the outset of their education. This is an integrated education program from the master’s level through the doctoral level. The completion of this program requires five years. E Type Possible to enter the doctoral program Career type (5D and 3D Program) S (Scientist) Type : Those who wish to become creative scientists E (Engineer) Type : Those who wish to become highly professional engineers 3D (3-year Doctoral) Program is a conventional doctoral level education program with a special emphasis on enhancing students’ practical and technical skills. The completion of this program requires three years. M (Master’s) Program is a conventional master’s level education program with a special emphasis on enhancing students’ technical skills. The completion of this program requires two years. Supervisory System At JAIST, students are guided through the education process using a unique supervisory system. Each student is assigned three advisors consisting of a supervisor, a second supervisor, and an advisor for the minor research project. This structure provides guidance and advice on the full range of education and research. In addition, JAIST offers a career advisor system to give students guidance and advice on general learning activities. Student Supervisor Second Supervisor Advisor for the Minor Research Project / Internship Study Materials Science in English As a globally focused institute, one of the advantages of attending JAIST is that all of the doctoral courses are taught in English. JAIST also offers the opportunity to obtain a master’s degree just by taking courses taught in English. Both the master’s and the doctoral students are encouraged to prepare and present their thesis in English. Polish Your Communication Skills / Critical Thinking Skills We offer both English and Japanese language courses from introductory level to business level taught by native speakers. JAIST offers courses to develop key transferable skills such as critical thinking and communication skills. These key strengths allow JAIST graduates to pursue a truly global career. 30 Support System for International Students International Student Section JAIST is proud to offer a fully staffed International Student Section at the Student Affairs Department. Support staff are not only friendly, but are also fully fluent in English. Our staff is happy to answer questions and support students’ everyday life. Check out the bilingual pamphlets published by the staff full of tips for your daily life in Japan. We also organize Japanese cultural excursions, 3 times per year, and you can enjoy, for example, tea ceremony in Kanazawa, together with Japanese students. They are also organizing a field trip for international students, once per year, which is a one-day tour to a city such as Kyoto, Hida-Takayama, or Ise, where you can enjoy traditional aspects of Japan. Tutorial Service Tutoring service is available for international students who have lived in Japan for less than a year. Tutors, who are Japanese students in most cases, will accompany you and help you with your everyday life, such as starting gas in the Student Housing, opens a bank account, or seeing medical doctors. Career Counseling Supports The Career Service Center in JAIST offers special support for international students who are seeking a job in Japan. The Center provides job-related information about job postings, corporate seminars, and internships for companies which are interested in hiring international students. Traveling expenses for going to internship or job interviews in the Hokuriku region will be supported. Half of the examination fee for the Japanese-Language Proficiency Test, the Business Japanese Proficiency Test, and the TOEIC test will be supported as well. International Exchange Associations You can also connect with the local community through organizations such as the Nomi International Friendship Association. These organizations provide international people with a wide variety of information and opportunities for getting to know each other. 31 Facilities for Students Student Housing Eight five-story Student Housing are located on campus. International students receive priority to live in Student Housing. Facilities: Single room: Kitchenette and toilet, Double and Family room: Kitchen, toilet, bathroom and laundry room. PC can be connected to the campus LAN. Library The library at JAIST is administered based on the three principles of “Open 24 hours a day“, “Research library“ and “Electronic library“. We are confident that the quality of our library is appropriate for a graduate school in terms of accessibility and the contents of its collection. ■Open 24 hours a day Books and other materials can be viewed freely whenever it is necessary. ■Research library Our collection is focused on academic materials that are highly professional and advanced. ■Electronic library We are promoting a digital system of academic materials. J-BEANS “J-BEANS” is the Learning Commons and a place where students, faculty and staff can study together and exchange academic ideas. The room could be used for a group learning or for a presentation, etc. Health Care Center The Health Care Center located on campus provides general health care services, including health examinations, first aid, health consultations and counseling, so that students and staff members can stay healthy in mind and body. Regular check ups are provided for all students in April every year. Also, people who work with X-rays can be specially examined, if necessary. The Health Care Center is furnished with beds, massage chair, sphygmomanometer, scales etc. for use. It also provides the theater room equipped with high quality sound and visual system. Students can use the room for self enjoyment. All these servises are free! Facilities for Campus Life Cafeteria and Cafe A wide variety of dishes are available in a comfortable and relaxed atmosphere. You can see the seasonal changes of nature through the windows. Convenience Store: New Yamazaki Daily Store Store hours Lines of business Monday-Friday 8:00AM-10:00PM. Saturday, Sunday, Holidays 9:30AM-5:00PM. Groceries, stationery supplies, magazines, home-delivery service, dry-cleaning agent, etc. Other Facilities *International phone calls can be made from the public telephones. *An ATM connected to major city banks on-line is located in the building. 32 Location JAIST is in the center of the Ishikawa Science Park located on a hill in the city of Nomi in Ishikawa Prefecture. The campus site enjoys scenic beauty, overlooking nearby counties and the city of Kanazawa to the north, the Sea of Japan to the west, forests and pastures to the south, and the spectacular Mt.Hakusan to the east. The area provides us with a variety of recreational facilities for every season, including several nearby ski resorts, beaches and seaside parks, golf courses, hot springs and athletic and recreational parks. With a population density far below that of the Pacific side of the island of Honshu, the area affords easy access to wilderness and outdoor recreation. Within 20km of JAIST is the historic city of Kanazawa, often referred to as the hidden gem of Japan, which hosts numerous cultural events all year round. CHITOSE Air : 1 hour 35 minutes SENDAI Air : 1 hour KANAZAWA Air: 1 hour 5 minutes Train : 2 hour 40 minutes Train : 2 hours 20 minutes FUKUOKA Air : 1 hour 20 minutes Train Air Train JR Komatsu Station Komatsu Airport JAIST Shuttle(Komatsu Airport Line, Komatsu Station Line) JAIST Komatsu Airport ー JAIST 40 minutes Komatsu Station ー JAIST 35 minutes ※If visitors will use the Shuttle(Komatsu Airport Line, JR Komatsu Station Line), reservations should be arranged for them by the JAIST faculty or the departments with whom they are visiting. JAIST Shuttle Hokuriku Railroad JR Hokuriku Railroad (Tsurugi Line) Local Train JR Nishi- Walk Train Ishikawa Line Kanazawa Kanazawa Ishikawa Line 5 minutes 11 minutes Station 4 minute Shin Nishi-Kanazawa 25 minutes Tsurugi Station Station Station (190 yen) (450 yen) (Free) JAIST We operate the JAIST Shuttle Service free of charge to provide transportation connecting JAIST with Komatsu International Airport, Japan Railway Komatsu Station and Hokuriku Railroad Tsurugi Station. 33 National University Corporation Japan Advanced Institute of Science and Technology School of Materials Science 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan Phone: +81-761-51-1111 E-mail: [email protected] http://www.jaist.ac.jp/ms/ [ YouTube ] http://www.youtube.com/JAISTClips [ Facebook ] https://www.facebook.com/MaterialsScienceJAIST [ Twitter ] https://twitter.com/jaist_ms_news [ Flickr ] https://www.flickr.com/photos/jaist_ms_news/