Canadian Orthopaedic Association 67th Annual Meeting Westin
Transcription
Canadian Orthopaedic Association 67th Annual Meeting Westin
Canadian Orthopaedic Association 67th Annual Meeting Westin Hotel, Ottawa, Ontario June 8-10, 2012 Abstract Supplement 1: Acetabular Cartilage Delamination Flap Viability in CAM-Type Femoroacetabular Impingement (FAI) Brad G Meulenkamp, ON; Paul E Beaulé, ON; Denis Gravel, ON; Arturo Cardenas-Blanco, ON Purpose: Femoroacetabular impingement (FAI) is a spectrum of hip pathology that is becoming increasingly recognized as both a source of hip pain and a precursor of osteoarthritis in young adult patients. Cam-type FAI is characterized by abnormal proximal femoral anatomy, which may result in delamination of acetabular cartilage at the labralchondral junction. The purpose of this study was to determine the viability of these acetabular cartilage flaps. Method: We retrospectively reviewed 12 hips from 11 patients found to have acetabular cartilage delamination when undergoing surgical dislocation for symptomatic FAI. All surgeries were performed by the senior author in an academic institution. Demographic data was collected to determine age at date of surgery, height, weight, and BMI. Hips were given a Tonnis grade of osteoarthritis based on the most recent plain film x-rays, and alpha angles -rays. Cartilage flaps were excised at time of surgery and sent to a single musculoskeletal pathologist for hematoxylin and eosin (H&E) staining for cartilage viability and characterization. Results: The mean age at surgery was 30.1 years (range 21-42): one female and 12 male patients; mean BMI 26.38 (20.8-30.9). Average Tonnis Grade was 1.58 and alpha angle 67.9 (53.0-80.0). Eleven of 12 cartilage specimens demonstrated 90% viability or greater on H&E staining under light microscopy. One specimen showed 40% viability. Six of 12 specimens were characterized as predominantly hyaline cartilage, four were mixed hyaline and fibrocartilage, and two specimens predominantly fibrocartilage. Conclusion: Acetabular cartilage delamination is known to occur in association with cam-type FAI, and is often resected at time of surgery. Our histological analysis of these flaps has demonstrated that they contain a high percent of viable chondrocytes, raising the possibility of repair (i.e. reattachment versus resection). Further study is needed to direct optimal treatment of these lesions. 2: Bone Mineral Density Study of the Femoral Neck after MOM Hip Resurfacing: A Randomized Clinical Trial of Cemented vs. Cementless Femoral Component Fixation Andrew Tice, ON; Paul E Beaulé, ON; Paul R Kim, ON; Laurent Dinh, ON Purpose: Neck narrowing after metal on metal (MOM) hip resurfacing (HR) is a concern for fracture and loosening of the femoral component. Some series have reported incidences of up to 30% with cemented fixation which has also been associated with thermal necrosis of the reamed femoral head. The purpose of this study was to quantify bone mineral density of the femoral neck of a cemented versus cementless femoral component for MOM HR. Method: One-hundred twenty patients (60 per group: cemented-Conserve Plus and cementless-CORIN) were recruited: 105 males and 15 females; mean age of 49.4 yrs (20-67); mean BMI of 28.9(20.3-42.1). BMD was measured in six femoral neck zones on the operative side and five zones on the contralateral side. Analysis used total contralateral BMD values as a covariate. Functional scores as well as complications and reoperations were documented. Results: Compared to the cemented group, the cementless one had greater BMD in zones 1 (p=0.03), 2 (p=0.04), 4 (p<0.001), and 5 (p=0.02) at 6 months post surgery, and in zones 1 (p=0.03), 2 (p=0.01), and 4 (p<0.001) at 1 year. Within-group analyses showed that the cemented group had greater BMD in zone 1 at the 1-year interval (p=0.01). The cementless group showed increased BMD in zone 1 at the 6-month interval (p=0.04), and in zones 1 (p=0.01) and 4 (p=0.04) at the 1-year interval. All patients improved significantly from their baseline functional score (HHS, WOMAC, UCLA). There were no differences in outcome scores between the two groups. There was one revision in the cemented group (due to adverse tissue reaction) and none in the cementless group. There were 2 complications in the cemented group (1 peroneal nerve palsy, 1 acute cup spin out) and 2 in the cementless group (1 hematoma, 1 posterior column fracture). Conclusion: Compared with a cemented femoral component, patients receiving a cementless implant had higher BMD levels at 6 months and 1-year post-operatively. Both groups had increased BMD over the follow-up period, particularly in zones 1, 3, and 4. Long-term evaluation is necessary to determine the potential association between BMD and implant survivorship between component designs. 3: Corrosion at the Head-Neck Interface of large Head Metal-on-Metal Hip Replacements Urs Peter Wyss, MB; Clive P Duncan, BC; Richard MR Dyrkacz, MB; Donald S Garbuz, BC; Nelson V Greidanus, BC; Bas A Masri, BC; Thomas R Turgeon, MB; Rizhi Wang, BC Purpose: Hip heads larger than 40mm were implanted with increasing numbers in the last 1015 years to reduce the incidence of subluxations, and to increase the range of motion. Some large head metal-on-metal articulation designs have higher revision rates after only a few years than other successful hip replacements. The main reasons are cup loosening, cysts, and pseudotumors, which are often associated with moderate to severe pain. The purpose of this study was to evaluate the severity of the head-neck corrosion of large heads It is possible that this corrosion can also lead to similar adverse metal reactions as caused by excessive articulation wear. Method: Thirteen acetabular cups of one manufacturer were revised of which seven had pseudotumors and one had small cysts. The stems were still well fixed in all cases, and were not removed during revision surgery. Full data was available for seven retrieved cups (six pseudotumors and one with small cysts). The average in vivo time for the seven completely analyzed cups was 42.6 months. The 12/14 mm taper in the head that articulated with the neck of the stem was assessed for corrosion and fretting. The taper corrosion and fretting, as well as the affected area, was scored from zero to three in four quadrants, and in the superior and inferior regions. The severity and area scores in each section were multiplied resulting in eight scores for corrosion and eight scores for fretting, producing a possible maximum score for corrosion of 72 and for fretting of 72 as well. Results: Six of the seven tapers were corroded with an average corrosion score of 21.0, and an average fretting score of 2.4. The average corrosion score was about 20% larger in the inferior region than in the superior region, and the average fretting score was about five times larger in the inferior region as compared to the superior region. The corrosion rate for the large head cups is 0.49/month, which is about five times larger than the corrosion rate for a sample of 59 28 mm metal-on-PE 12/14 mm taper cups. The corresponding fretting rate of 0.06/month is about 20% larger for the large head cups. Conclusion: In summary, it appears that larger heads with otherwise the same 12/14 mm taper have higher corrosion and fretting rates than smaller heads. This is of some concern, as it is known that higher than normal articulation wear rates can lead to an increased release of metal particles and increased ion levels in blood. These are possible causes for hypersensitivity reactions, pseudotumors, and cyst formation. Therefore, it is possible that higher corrosion rates at the head-neck interface of large heads can also contribute to pseudotumors and cyst formation. 4: Does Head Size Affect The Rate Of Corrosion And Fretting Damage Along The HeadNeck Interface Of Artificial Hip Joints? Richard Michael Ryan Dyrkacz, MB; Jan M Brandt, MB; Olanrewaju Ojo, MB; Thomas R Turgeon, MB; Urs Peter Wyss, MB Purpose: Corrosion and fretting are problems associated with the head-neck interface of modular hip prostheses. The goal of this retrieval analysis was to determine if the rate of corrosion and fretting damage for the head-neck interface was affected by head size. We also investigated if there was a relationship between corrosion and fretting damage along the headneck interface. Method: The hip prostheses were obtained from a local implant retrieval database and consisted of 74 heads and 40 stems manufactured by two companies. We selected modular hip prostheses that were implanted for at least one month featuring a 28 mm or a 36 mm diameter head, a 12/14 mm Morse taper, and a metal-on-polyethylene articulation. The material of all the heads and stems was CoCr alloy. The neck of the stem and the bore of the head were separated into superior and inferior regions and also divided into four quadrants. This resulted in eight regions for each of the heads and necks. Each region received a score of zero to three to represent the severity of corrosion or fretting damage and another score for the area damaged. Once a region received scores for severity and area, these two scores were multiplied to form a regional score for corrosion or fretting. For any given head or neck, all of the regional scores were added together to determine separate corrosion and fretting scores that were independent of each other. The maximum score for either corrosion or fretting would be 72 for a head or neck component. Finally, the corrosion and fretting scores were divided by the implantation time to reveal the corrosion and fretting rate scores. Results: When examining the corrosion and fretting scores between the two head size groups, there seemed to be a negligible difference between the two groups. Additionally, there were no significant differences in the corrosion and fretting scores of the heads and necks from the two different manufacturing companies. Corrosion and fretting damage were moderately correlated with each other upon examining the heads (r = 0.706 for the 28 mm head group; r = 0.885 for the 36 mm head group) and the necks (r = 0.829 for 28 mm head group; r = 0.978 for 36 mm head group). However, the rate of corrosion and fretting attack was significantly greater in the 36 mm head group in comparison to the 28 mm head group. The rate of corrosion and fretting attack for the 28 mm head group ranged from 0.1 to 0.3 (corrosion/fretting score per month) whereas the rate ranged from 0.3 to 2.4 (corrosion/fretting sore per month) for the 36 mm head group. This may be attributed to a greater torque caused by a larger head size during activities of daily living. Conclusion: With the release of metal ions and corrosion products, this may elevate the concentrations of cobalt and chromium. By having an increase in the concentrations of cobalt and chromium, this could trigger hypersensitivity and the presence of pseudotumors, which is similar to what is being observed with metal-on-metal articulations. 5: Optimum position of the Acetabulum in Hip Resurfacing- A Finite Element Analysis study Ravindra Gudena, UK; Amin Komeili, AB; Behzad Vafaeian, AB; Jason Werle, AB; Samer Adeeb, AB; Elrich Marwan, AB; James Powell, AB Purpose: Metal on metal hip resurfacing arthroplasty is losing its popularity due to complications secondary to metal wear debris. Component alignment has an important role in reducing metal wear debris. We created a Finite Element Analysis model to investigate the effect of acetabular component position on the contact stresses across the bearing surfaces. The results obtained have identified the optimal position of the acetabular component with the least contact pressure across the metal on metal bearing. Method: Three D Finite Element Model (FEM) of the hip including the pelvis, the femoral head and the implant was developed. The raw 3D geometrical shapes of pelvis and femur were reconstructed from the Computed Tomography DICOM-files using the MIMICS (Materialise' Interactive Medical Image Control System) software. The model was then imported into Geomagic® to generate smooth analytical non-uniform rational b-spline surfaces. The 3D geometries of the prostheses were reconstructed using a laser scanning device. Assembly of the components was performed in SolidWorks®, meshed using HyperMesh® (Hyper Works Suite, ALTAIR), and then exported to ABAQUS Finite Element software. The boundary conditions of the model simulated single-leg stance with fixed sacroiliac joint and pubic symphysis and incorporated the active abductor muscle forces. Material properties were attributed to the cortical bone, cancellous bone, cement and to the implant. The coefficient of friction at the bearing surfaces was defined as 0.006. The femoral component position was fixed in five degrees of valgus. The acetabular component was placed in 35, 40, 45 and 50 degrees of inclination coupled with angles of 0, 5, 10, 15, 20, and 25 degrees of anteversion. Overall, 24 models were prepared to investigate the optimal position associated with the minimum contact stresses. Results: Models with smaller inclination and anteversion angles produced the lowest stresses within the hip resurfacing components. High inclination angles showed consistently higher von Mises stresses. While the model predicted lower stresses for anteversion angles using 0 and 5 degrees of anteversion angles, this might lead to instability with subluxation and dislocation. Thus, the optimum range of inclination angles was defined as 35-45 degrees and anteversion angles as 10-20 degrees. The recommended range of combined anteversion angles from our model was 22-32 degrees. Inclination angles of greater than 50 degrees and anteversion angles 25 degrees or greater caused increased contact stress and impingement. Conclusion: Malposition of the components is related to increased wear and pseudotumor formation in hip resurfacing arthroplasty. In this study we developed a numerical model which predicted the range of optimum positions of the acetabular component with the lowest contact stresses. This study sheds some light on the stresses developed and offers recommendations for the optimum position of the acetabular component in hip resurfacing. The aim should be to place the acetabular component in this recommended position thus reducing the risk of wear- related complications. Optimal implant position will allow hip resurfacing to be a viable option in young active adults with hip arthritis. 6: Comparison Of Alumina-Alumina To Metal-Polyethylene Bearing Surfaces In THA: A Randomized Study With 9 To 15 Years Follow-Up Charles Rivière, QC; Pascal-André Vendittoli, QC; Martin Lavigne, QC; Pauline Lavoie, QC; Nicolas Duval, QC Purpose: Achieving best long-term result, especially in active young patients, relies on multiple factors including surgical technique, implant design and optimal bearing surfaces. Revision secondary to high wear rate of Metal on Poly (MoP) put this choice on the bottom of the bearing surface choices when considering THR in young and active patient. Complications such as adverse reaction to metal debris (ARMD) render using Metal on Metal (MoM) bearing a concern full option. On the other hand Ceramic on Ceramic bearing surface with improved acetabular shell and stem design can be reliable alternative bearing surface with significantly lower complication rate as compare to other conventional or alternative bearing surfaces. There are no long-term results of randomised study comparing those bearing surfaces. We previously published a report with 4 to 9 years follow-up and updated it to present long-term results (9-15 years) of randomized clinical trial that compares MoP and CoC bearing surfaces. Method: Randomization of 140 patients with age less than 70 years was done for those going through THA between 1996 and 2001. Hybrid THA was implanted (ceraver osteal) in all patients. The bearing surfaces for one group (71 patients) was aluminia-aluminia and the second group (69 patients) was Metal-on-polyethylene. Clinical scores (WOMAC, UCLA and merle d’aubigné scales) and radiological evaluations (for osteolysis, loosening, wear rate using Imagica software) were recorded at the average of a maximum follow-up of 12.1 years (9 - 15). Results: At final follow up, 107 clinical scores was available (107 THR, 55 MoP and 52 CoC) and only 77 x-ray (39 MoP and 38 CoC) were available to review. Total of 9 patients had to be lately revised (8 of them was in the MoP group). The causes of revision in the MoP group were loosening with sever osteolysis (femoral 4 patients, acetabular 1 patient), and sever isolated liner wear (3 patients). The only revised case from the CoC group was secondary to stem loosening with sever Femoral osteolysis. Osteolysis were observed in 8 MoP THR compared to 1 CoC THR, and was significantly associated with wear and annual wear >0,2mm/y. The average rate of wear was estimated to be 0.19mm/y for the poly group and un-measurable for ceramic group. Increased cup abduction angle and decreased femoral offset in MoP group were significantly associated with higher wear rate. Long term functionnal results seems to be better in aluminia group with a Statistical significant deference concerning post-operative UCLA score and some items in the Womac one. Conclusion: The high revision rate in MoP group secondary to wear related complication was statistically significant if compared to the CoC group. The encouraging long-term result of alternative bearing surfaces using CoC with a zero incidence of fracture or squeaking can classify a well-designed CoC bearing on top of bearing surface options especially in young and active patients. 7: Imageless Navigation Improves Femoral Component Implantation Accuracy using Conventional Jig Instrumentation Zachary Morison, ON; Michael Olsen, ON; Emil H Schemitsch, ON Purpose: This study examines how imageless navigation improves the accuracy of femoral component implantation using conventional jig instrumentation. Method: Post-operative digital radiographs were used to assess the position of Birmingham Hip Resurfacing (BHR) components implanted using a manual jig prior to any experience with computer-assisted surgery (Cohort One) compared to a cohort of BHR components implanted with a manual jig after having used imageless navigation (Cohort Two). Cohort One consisted of 17 patients implanted with BHR components prior to the surgeon having any experience with imageless navigation, and Cohort Two included 9 patients implanted with BHR prostheses after the surgeon trained with 187 cases of imageless navigation. All hip resurfacings included in this study were performed by a single surgeon (EHS) using a conventional lateral pin jig. A single observer measured the component position in both the coronal and sagittal planes. Those values measured for the component position were then compared to the pre-operative planned position determined by the lead surgeon’s (EHS) surgical protocol. Descriptive statistics were used to calculate the differences between the final component placement and the target position. A two sample t-test was then used to compare the values from the two cohorts. Results: The mean deviation of the stem-shaft angle (SSA) from the target position was determined to be 5.6 degrees (SD, 4.3°, 95% CI, 3.6°, 7.6°) in Cohort One and 2.2 degrees (SD, 2.2°, 95% CI, 0.8°, 3.7°) for those in Cohort Two. This difference between the two groups was calculated to be statistically significant (p = 0.01). The variance of Cohort One was determined to be 17.6 degrees compared to only 4.9 degrees in Cohort Two. This shows that the number of outlying implant positions was greatly reduced. With respect to component version, the mean deviation from the target stem-neck angle (SNA) of Cohort One was 7.3 degrees (SD, 5.3°, 95% CI, 4.8°, 9.9°). Cohort Two had a mean difference of 4.0 degrees (SD, 2.2°, 95% CI, 2.6°, 5.4°), and this value is also significantly less than Cohort One (p =0.03). The range for the implant positions in Cohort One was -17.2 degrees to 5.8 degrees as compared to -8.2 degrees to 3.6 degrees. This demonstrated less extreme positioning in Cohort Two, as four of the 17 implants in Cohort One were considered to be retroverted (>10°). Conclusion: Our findings show that more accurate and precise implant placement was achieved after experience with computer-assisted surgery. This may suggest that surgeons learning the hip resurfacing procedure should undergo training with both the conventional lateral pin jig and imageless computer navigation in order to curtail surgical complications during the surgeons’ early cases. 8: Quantification of Rim Notches in Retrieved Acetabular Polyethylene Liners using Micro-Computed Tomography Matthew Teeter, ON; Nicholas Paterson, ON; Steven JM MacDonald, ON; Richard McCalden, ON; James L Howard, ON; Douglas Naudie, ON Purpose: Recent literature suggests that unsupported crosslinked acetabular liner designs may have increased susceptibility for crack initiation. Unsupported rims using an external linerlocking mechanism have demonstrated notching patterns, even at short implant durations, that may be a point of crack origin and rim failure. The purpose of this work was to examine whether (1) symmetrical notching patterns and rim cracks existed and demonstrated similar morphological properties in retrieved crosslinked and non-crosslinked liners, (2) microcomputed tomography (micro-CT) was able to quantify the dimensions of these notches and examine underlying subsurface changes; and (3) whether the dimensions of these notches correlated with their duration of implantation. Method: From 14 patients, we retrieved ten crosslinked and four non-crosslinked liners of the same design that had been in-vivo for an average of 2.03 years. Liners were microscopically examined to determine the presence of cracks and rim notches and then scanned using microCT to quantify notch dimensions and determine subsurface changes to the polyethylene. Results: All liners demonstrated identical notching patterns in the anti-rotational scallops of the unsupported rim. Micro-CT scans demonstrated no signs of crack initiation or rim failure, and were able to accurately quantify the notch dimensions. Of the three dimensions, only the length vs. implant duration regression in the non-crosslinked group was significantly different (r2 = 0.949, p = 0.026) from zero. Notches appeared early (< 1 month) and remained relatively stable in size even at midterm durations of implantation in both cohorts. Conclusion: The finding that notches exist in the anti-rotational scallop of this liner model has only recently been reported. Our intent was to confirm the etiology of these notches and their susceptibility to becoming cracks, which may in turn jeopardize the longevity of the implant. Our results suggest that the notching patterns caused by liner-cup micromotion may be more indicative of creep deformation than cracking, as they do not progress markedly over longer durations of implantation. Unsupported acetabular liner designs that use an external linerlocking mechanism may not be more susceptible to crack propagation and rim failure. We recognize that most implant manufacturers are moving away from uncaptured acetabular liner designs and towards a fully captured liner locking mechanism without external anti-rotation scallops. Nonetheless, the findings of this study remain relevant to those surgeons who have treated and continue to follow patients who have received this type of liner, and to all those involved in the design and manufacture of future implant designs. 9: Surface Damage Characteristics on Thirty-Five Retrieved Ceramic-on-Ceramic Hip Replacements Trevor C Gascoyne, MB; Thomas R Turgeon, MB; Jan M Brandt, MB Purpose: Ceramic-on-ceramic (C-C) total hip replacements (THRs) are an attractive option for young, active patients. However, more clinical data is necessary to establish the reasons of failure of contemporary C-C THRs in vivo. The objective of the present study was to assess the surface damage on retrieved C-C THRs and determine possible influential factors that may explain their in vivo performance. Method: Thirty-five C-C retrievals of material type Biolox® Forte (n=28) and Biolox® Delta (n=7) were collected after a mean of 3.7 ± 3.2 years in vivo. Semi-quantitative surface damage assessment and contact profilometry were performed on all retrievals to obtain both a damage score (DS) and microscopic assessment of the types of surface damage, such as metaltransfer and stripe-wear areas. Scanning electron microscope (SEM) images were obtained of two femoral heads displaying areas of typical surface damage. Results: All retrievals showed evidence of macroscopic surface damage. The implantation period correlated with the damage score (DS) of the femoral heads (r=0.573, p <0.001) and the acetabular cups (r= 0.565, p<0.001). However, the metal-transfer DS of the femoral heads did not correlate with implantation period (r=0.185, p=0.29). Patient age and body mass index (BMI) did not correlate with DS. Surface roughness of metal-transfer areas were positively skewed (additive metal transfer) while the stripe-wear areas were negatively skewed (grain removal), as evidenced by SEM analysis. Four patients reported squeaking in their C-C THRs; one of which was a 54 yr-old male patient who completed three full marathons with his implant. The DS for this retrieval was below average, with metal-transfer being the only damage feature. Fracture of the acetabular liner occurred in three patients, all of which had malpositioned components. Stripe-wear was seen on one Biolox® Delta C-C THR which had been implanted for 5 years in a 48 year-old female patient. Conclusion: The overall DS and the stripe-wear DS correlated with implantation period, whereas the DS for metal-transfer did not. This finding may indicate that metal-transfer, which can occur during primary surgery during open hip reduction, may have a relationship with stripe-wear. The presence of metal-transfer on the ceramic surface is believed to cause a local alteration of the implant tribology which may facilitate stripe-wear surface damage via an adhesive wear mechanism. Therefore, direct contact between the Ti-alloy acetabular shell and the ceramic femoral head should be avoided at primary surgery. Ceramic-on-ceramic THRs remain an attractive option for young, active patients, but care must be taken during implantation to appropriately position the acetabular cup and to avoid unwanted metal-transfer as such alteration at the bearing interface may change implant tribology. 10: A Comparison of Stereology, Structural Rigidity and a Novel Measure of 3D Bone Connectivity in the Assessment of Torsional Strength and Stiffness in a Mouse Tibia Fracture Model David Wright, ON; Diane Nam, ON; Yufa Wang, ON; Maarten Beek, ON; Cari M Whyne, ON Purpose: Although the majority of long bone fractures heal successfully, due to the high incidence of these injuries there exists a need for effective evaluation and treatment methods for the 5-10% that progress to non-union. Accurate methods to quantitatively assess fracture healing are important to understanding both normal and pathologic bone healing. Healing of a bone fracture is ultimately described by the mechanical stability of the fracture callus. The development of non-invasive quantitative tools to assess stability is important for both clinical applications and pre-clinical studies. The objective of this study was to develop a novel μCTbased measure of three-dimensional bone connectivity and to compare its ability to assess fracture callus mechanical stability to previously described measures. Method: Mid-shaft unilateral tibia fractures were produced via a diaphyseal osteotomy in 10 mice pre-stabilized with an intramedullary pin. At 28 days post fracture, μCT images were acquired of the harvested tibiae (8μm resolution) adjacent to calibration phantoms. Stereologic parameters were quantified based on 3D callus geometry and mineralization, including torsional rigidity calculated based on the axial μCT slices. Biomechanical torsion testing was conducted to determine maximum torque and torsional stiffness. Post failure μCT images acquired of the bone fragments were used to identify the failure surfaces. Connectivity and torsional rigidity were then evaluated based on these failure surfaces. Results: Stereologic measurements of the callus were found to be significantly correlated to torsional strength and stiffness (R2=0.601 and R2=0.787, respectively for bone volume), whereas no significant correlations were found between 2D minimum torsional rigidity and mechanical strength or stiffness in contrast to previous investigations. A moderate correlation was found for 2D average torsional rigidity and stiffness (R2=0.504). Bone connectivity parameters local to the failure surface, specifically the surface area and torsional rigidity of connected bone, were found to significantly correlate with mechanical stiffness, and proved superior to previously developed 2D measures of torsional rigidity (R2=0.615 to 0.663). Visualization of the failure surfaces demonstrated a consistent failure pattern indicative of the applied torsional loading, with locations of the failure surfaces involving the fracture callus at varying levels. Conclusion: The results of this proof of concept work indicate the potential utility of these novel connectivity and torsional rigidity analyses in non-invasive assessment of fracture callus stability based on identified failure surfaces. Pre-fracture identification of failure surfaces and the application of connectivity/rigidity analyses to other fracture models (healing stages, complexity of fracture, loading patterns) will determine the ultimate effectiveness of this new approach. 11: Effect Of Neonatal Mice Exposure To Diethystilbesterol On Intervertebral Disc In Male And Female Adult Progeny Subjected To Swimming Exercise Rahul Gawri, QC; Sora AlRowas, QC; Rahul Gawri, QC; Rami Haddad, QC; Lorraine Chalifour, QC; John Antoniou, QC; Fackson Mwale, QC Purpose: Neonatal exposure to Diethylstilbestrol (DES) has been shown to adversely affect a number of estrogen sensitive tissues, including bone. Effects of in utero DES exposure have also been shown to affect the third generation. Environmental exposure to estrogens was shown to be higher than anticipated. The aim of this study is to determine the effect of in utero exposure to DES on the intervertebral disc (IVD) of adult mice. Method: Pregnant C57/bl mice were injected with either vehicle (peanut oil) or one of three doses of DES (0.1, 1.0, and 10.0 µg/kg/day) at 11-14 days of gestation. A minimum of 3 dames was set for each group. Pups were then allowed to grow to adulthood without further intervention until three months of age. At this point mice were randomized into two groups; one with a once daily swimming regimen which started as five min. and was escalated to a maximum of 1 h. The second group were left to their normal activity level and considered sedentary. All animals were sacrificed at exactly 4 months of age. The lumbar segment of the spines was dissected from 3 animals per group for histological evaluation and were stained with 0.1% Safranin O and counter stained with 0.02% Fast Green. Three measurements of disc height were taken per disc and the means compared for control vs. DES exposed mice. Whole intervertebral discs were isolated, digested proteoglycan content was measured using the DMMB assay. Results: Parameters associated with IVD degeneration were found to have higher scores in DES exposed mice vs. Controls. Clefts in the NP were only significantly increased in the female swim group at 0.1 µg/kg/day whereas the female sedentary group showed significant increases at all three doses of. NP clefting was less evident in males, where the male swim group showed a significant increase at 0.1 and 1.0 µg/kg/day and the male sedentary group showed a significant increase at 10.0 µg/kg/day .Tears in the AF showed a similar pattern as NP clefting, where the female swim group was only affected at 0.1 µg/kg/day and the female sedentary group showed significant increases at all three doses. Swimming caused an overall worsening of scores in females. Males were less affected by swimming than females. Proteoglycan content in the intervertebral disc was significantly decreased at 0.1μg/kg/day and 1.0 μg/kg/day. A significant increase was noted at10.0 μg/kg/day as compared to control. Conclusion: The intervertebral disc was recently shown to be an estrogen-sensitive tissue. This had a clinical effect in obese postmenopausal women undergoing hormone replacement therapy.Our study shows that DES in utero exposure can cause nuclear extrusion and affect the intervertebral disc. The mechanisms of the effects of DES are however not well understood and further studies are necessary. This study might shed light on the possible increased risk of disc degeneration in the sons and daughters of mothers exposed during gestation, as well as their children. 12: Fracture Healing With Endothelial Progenitor Cells (EPCs) in a Bone Defect Model: A MicroCT and Biomechanical Comparison with Mesenchymal Stem Cells (MSCs) Aaron Nauth, ON; Ru Li, ON; Ravi Purushuttam, ON; Erion Qamirani, ON; Emil H Schemitsch, ON Purpose: The purpose of this study was to compare the effects of two types of stem/progenitor cells on the healing of critical sized bone defects in an animal model. Endothelial Progenitor Cells (EPCs), a novel cell type with previously demonstrated effects on angiogenesis, were compared to both a control group, and a treatment group of Mesenchymal Stem Cells (MSCs) using microCT, biomechanical testing, and Laser Doppler Imaging of blood flow at the fracture site. The hypothesis was that EPCs would demonstrate both superior bone healing and angiogenesis, when compared to the control group and MSC group. Method: EPCs and MSCs were isolated from the bone marrow of syngeneic rats by differential culture and grown ex vivo. Subsequently the cells were harvested, seeded on a gelfoam scaffold, and implanted into a 5mm segmental defect in a rat femur that had been stabilized with a plate and screws. Bone healing was assessed by microCT and biomechanical testing. The capacity of cell treatment for therapeutic angiogenesis was assessed by histology and physiologically, using laser doppler to assess blood flow at the fracture site. ANOVA was used to test for significant differences between the groups, and a p-value of <0.05 was considered statistically significant. Results: MicroCT comparison of the EPC group (n=14) versus the control (n=14) and MSC groups (n=14) showed significantly superior bone formation in the EPC group at the bone defect site for all parameters tested. Biomechanical testing demonstrated superior torsional strength and stiffness in the EPC group versus control and MSC groups. Laser Doppler assessment showed significantly more soft tissue and bone blood flow at 2 and 3 weeks in the EPC group versus the control and MSC groups. More blood vessel formation was observed in the EPC group versus controls on the basis of histology at 3 weeks. Conclusion: The results of this study demonstrate that EPCs are effective as cell-based therapy for healing critical sized bone defects in a rat model. In this model EPCs demonstrated superiority to MSCs with regards to angiogenesis and bone healing. These results strongly suggest that EPCs are effective for therapeutic angiogenesis and osteogenesis in fracture healing. There is a clinical need for effective strategies in the management of traumatic bone defects and non-unions. Investigation into the use of MSCs as an effective alternative to autologous bone grafting has failed to translate into clinical use. It is possible that EPCs are more effective at the regeneration of bone in segmental defects because of their synergistic effect on angiogenesis and osteogenesis. Further research into EPC based therapies for fracture healing is warranted. 13: HR-pQCT Measured Bone Microarchitecture and Estimated Bone Strength Can Classify Postmenopausal Women With and Without Previous Forearm Fractures Kyle K Nishiyama, AB; Heather M Macdonald, BC; David A Hanley, AB; Steven K Boyd, AB Purpose: Measures of bone microstructure and estimates of bone strength can be obtained with high-resolution pQCT (HR-pQCT); however, it is unclear if these parameters can be used to classify people with fractures. Our objective was to determine if HR-pQCT measurements and finite element (FE) estimates of bone strength could distinguish between women with and without low-trauma forearm fracture. Method: We studied postmenopausal women in the Calgary cohort of the Canadian Multicentre Osteoporosis Study (CaMos) for whom we had 10-year fracture data and HRpQCT (XtremeCT, Scanco Medical AG) scans at the completion of the study. During the follow-up, 14 women reported low trauma forearm fractures and were each randomly matched by age (+/- one year) to two women without fractures (Total N = 42, 72.9 ± 8.3 yrs.). In addition to standard HR-pQCT measurements (Boutroy et al. 2005), we measured cortical thickness, porosity (Buie et al. 2007; Nishiyama et al. 2010), finite element ultimate stress, and the portion of the load carried by the cortical and trabecular regions (MacNeil and Boyd 2007) in all subjects. We used DXA to measure femoral neck (FN) and lumbar spine (LS) areal BMD. Support vector machines (SVM; WEKA, University of Waikato) were used to classify women with and without fracture. A 10-fold cross validation scheme was used to gauge the accuracy and generalizability of the model. Results: The first model was based on all HR-pQCT and FE parameters, the second model used FE measurements alone, and the third model used DXA aBMD (LS and FN) alone. The SVM based on all parameters correctly classified 35 of the 42 subjects in the cross validation (Accuracy = 83.3%, Sensitivity = 73.3%, Specificity = 88.9%, Kappa = 0.63, ROC AUC = 0.84). Using only FE parameters, 34 subjects were correctly classified (Accuracy = 81.0%, Sensitivity = 66.7%, Specificity = 91.7%, Kappa = 0.60, ROC AUC = 0.81). Areal BMD was not able to distinguish the fracture cases resulting in 28 correct control subjects (Accuracy = 66.7%, Sensitivity = 66.7%, Specificity = 0.0%, Kappa = 0.00, ROC AUC = 0.50). Conclusion: Combined HR-pQCT and FE measurements and FE measurements alone had good accuracy classifying women with forearm fractures vs. age-matched controls, while FN and LS DXA measurements failed to classify subjects. HR-pQCT may help to predict individuals at risk of forearm fracture in a prospective study and form a basis to identify which parameters from HR-pQCT and FE analysis are critical for assessing fracture risk. 14: Mast Cells and Their Role in Bone Regeneration Michael H Wang, QC; Michael B Sullivan, QC; Xuejiao Li, QC; Janet E Henderson, QC; Paul A Martineau, QC Purpose: Tissue engineering through mast cell-induced bone regeneration has emerged as a novel idea that can offer the advantages of autologous bone graft transplantation for skeletal reconstruction without associated limitations of suitable donor sites and shortage of donor tissue. Recent technological advances in micro computed tomography (Micro CT) now allow bone micro architecture to be investigated in addition to standard histological methods. Previous research has not established the specific role of mast cells in bone regeneration and has not explored the timing of bone healing. Therefore, the current study has two objectives: 1) To demonstrate whether bone regeneration will be significantly disturbed in mast cell deficient mice; and 2) To establish the timing of bone healing in wildtype and mast cell deficient mice. Method: Femoral cortical window defect surgeries were performed on male and female C57Bl6/J strain mice, with ages ranging from 16-20 weeks, from both wildtype and mast cell deficient genotypes. As a model for bone regeneration, a cortical window defect with dimensions of 1mm x 3mm penetrating from bone cortex to bone marrow was generated bilaterally on mice femurs. After mice were euthanized at postoperative zero, two, and four weeks, femurs were scanned using Micro CT. Quantification of percentage bone volume was performed by analyzing bone volume fraction (BV/TV) on a region of interest within the window defect where bone healing occurred. A non-parametric Mann-Whitney U-test with a significance value of α=0.05 was used to evaluate the difference in bone healing between wildtype and mast cell deficient mice at each of the time points. Results: When genotypes were compared, wildtype mice started with the same bone volume fraction as mast cell deficient mice at baseline postoperative zero weeks (p=0.517). Wildtype mice showed significantly higher BV/TV compared to mast cell deficient mice at postoperative two weeks (p=0.042). Wildtype mice and mast cell deficient mice ultimately achieved similar bone volume fraction at postoperative four weeks (p=0.104). When time points were compared, both genotypes showed significantly higher BV/TV at postoperative two weeks and postoperative four weeks relative to the baseline postoperative zero weeks. Mast cell deficient mice showed significantly higher BV/TV at postoperative four weeks relative to postoperative two weeks (p=0.011), but this difference was absent in wildtype mice. Conclusion: Bone regeneration still proceeds in the absence of mast cells. However, there is a delay in the bone healing of mast cell deficient mice compared to wildtype mice. This delay in bone regeneration warrants histological investigation to further strengthen Micro CT data and possibly suggest a molecular explanation for this phenomenon, such as delayed osteoblast recruitment. 15: The Effect of Photodynamic Therapy (PDT) on Long Bone Fracture Healing Margarete K Akens, ON; David Wright, ON; Sadiya Yousef, ON; Diane Nam, ON; Albert JM Yee, ON; Brian C Wilson, ON; Cari M Whyne, ON Purpose: Comminuted fractures resulting from high impact trauma can result in delayed healing or non-union. Despite currently available treatments to reduce the risk of infection and/or enhance bone healing, such as the use of antibiotic-impregnated beads or bonemorphogenetic proteins, these fractures can take up to a year to fully heal. Photodynamic therapy (PDT) is a non-surgical, non-ionizing minimally invasive local treatment, which has been successfully applied to treat multiple types of cancer and skin diseases. Surprisingly, recent findings from studies aimed at understanding the impact of PDT on vertebral metastases have shown that PDT rapidly improved vertebral bone strength, stiffness and architecture. Based on these observations, the aim of this study was to explore the potential of PDT to enhance healing in traumatic long bone fractures. Method: A comminuted tibia fracture was generated under general anaesthesia in 11 adult female Sprague-Dawley rats. Prior to fracture generation a 0.8 mm Kirschner wire was placed inside the medullary canal. The unilateral fracture was generated in the mid-tibia with a custom drop weight impact apparatus (500g). The rats were randomly allocated to 3 groups: control (no treatment), PDT applied 1 day (1d) or 7 days (7d) post-fracture. PDT treatment was administered using the photosensitizer BPD-MA (1.0 mg/kg; Visudyne). Fifteen minutes later, laser-light (690nm; 75J) was administered to the fracture site. The rats were euthanized 4 weeks after fracture generation and their tibiae were harvested. μCT images at an isotropic 14 μm/voxel resolution (SkyScan 1172 High Resolution MicroCT System, Skyscan, Belgium) were acquired of the fracture site and callus for 3D architectural analysis (CTAn, Skyscan). Results: All rats recovered well from the fracture generation and PDT treatments. The total bone volume (TV), including callus formation, of the fracture site increased from 148±43mm^3 in the control group, to 157±59mm^3 in the PDT 1d group (6%) and to 175±25mm^3 in the PDT 7d group (18%). Similarly, the bone volume within the callus (BV) increased from 75±8mm^3 (control), to 78±19mm^3 (1d-PDT) and 85±11mm^3 (7d-PDT). Conclusion: PDT treatment of the fractured rat tibiae resulted in an increase of bone formation as compared to control untreated fractures, despite the high variability in the generation of the comminuted fractures. Further, the relative increases (compared to control) in both bone and callus volume in the 7d PDT group was found to be ~3 times higher than in the 1d PDT group. This suggests that the tissue response to PDT stimulation may be dependent on the fracture healing remodeling stage. If PDT is able to enhance fracture healing in complex fractures it may provide a cost-effective local minimally invasive treatment for long bone fractures at risk for impaired bone healing, even in situations where there is a delay in medical care. 16: The Effect of Radial Head Excision and Arthroplasty on Medial Collateral Ligament Tension Louis M Ferreira, ON; Katherine E Fay, ON; Emily A Lalone, ON; James A Johnson, ON; Graham JW King, ON Purpose: Displaced comminuted radial head (RH) fractures, primary and post-traumatic osteoarthritis, and rheumatoid arthritis are often treated with RH excision or arthroplasty. RH excision has been predicted by some biomechanical studies to increase tension in the medial collateral ligament (MCL). However, the effects of RH excision and arthroplasty on the loading characteristics of the MCL have not been quantified experimentally. The purpose of this in-vitro study was to determine the effect of RH excision and arthroplasty on the magnitude of MCL tension during elbow flexion. We hypothesized that tension in the MCL would increase with RH excision, and that RH arthroplasty would restore MCL tension levels similar to that of the native RH state. Method: Five cadaveric elbows underwent active flexion with the arm in the vertical and valgus orientations using a motion simulator, and with the forearm fixed in neutral rotation. Tension in the anterior bundle of the MCL was measured with a custom-built transducer interlaced with the MCL. Trials were performed for the native RH, RH excised, and RH arthroplasty conditions. Results: Increasing flexion angle tended to increase MCL tension for all trials. In the vertical orientation, average MCL tension over the whole flexion range was: native RH = 24.4±19.2 N, RH excised = 44.5±24.4 N, and RH arthroplasty = 29.9±24.8 N. Due to data acquisition difficulties, results were not collected for one specimen in the vertical orientation, and no significant effect of RH condition on MCL tension was detected (p = 0.06). In the valgus orientation, average MCL tension over the whole flexion range was: native RH = 79.7±29.0 N, RH excised = 97.3±27.2 N, and RH arthroplasty = 88.0±31.2 N. Tension was greater for RH excised than native RH (p=0.006). There was no difference in tension between the native RH and the RH arthroplasty (p=0.1). Conclusion: Tension in the MCL increased with elbow flexion, indicating that other structures are responsible for joint stability near full extension, and that the MCL is recruited at increased flexion angles. In other words, the MCL is an important valgus stabilizer in mid-flexion. This invitro study demonstrates that MCL tension increases following radial head excision, and is restored to native levels following radial head arthroplasty. Radial head arthroplasty decreases MCL tension levels compared to radial head excision and, therefore, may reduce the incidence of cubitus valgus deformities which have been reported following radial head excision. 17: Localized Correction Of Thin-Bone Geometry And X-Ray Intensity Information In Clinical CT Images Amirreza R Pakdel, ON; Normand Robert, ON; Jeffrey Fialkov, ON; Cari M Whyne, ON Purpose: The capability to construct patient-specific finite element (FE) models to simulate the in vivo biomechanical environment of the skeleton holds great promise for the design of effective treatments for traumatic injuries, deformities, and numerous pathological conditions. The most feasible means of constructing such FE models relies on segmentation of cortical and trabecular bone structures in x-ray computed tomography (CT) images. To date, accuracy of the constructed models has been limited by the resolution of clinical CT scanners, in particular with respect to delineation of thickness and intensity measurements in compact thinbone regions, such as those found in the pelvis and the craniofacial skeleton. This study presents an automated algorithm for localized correction of thin-bone geometry and x-ray intensity information in CT datasets. Method: A method is presented for estimating the true intensity profile of thin-bones (<1.0mm thickness), which exploits the x-ray attenuation and material density information inherent in clinical CT data sets. This implementation models the overall result of limited pixel size, partial volume, and other blurring effects of high contrast areas by convolution of an idealized rectangular function with a Gaussian function. Using local cortical bone intensity and the integral area of a line profile sampled normal to the bone surface as inputs, a Gaussian function is computed as the point-spread function (PSF). Deconvolution of the sampled profile with the PSF yields an approximated representation of the true thin-bone profile. Custom CT phantoms were first imaged (0.23x0.23x0.625 voxel size) to validate the method (GE Lightspeed VCT). A cadaveric head was then imaged (0.48x0.48x0.625 voxel size) and the deconvoultion method applied to the maxillary sinus. Micro-CT scans (Explore Locus, GE) were acquired of the excised maxillary sinus to serve as a gold standard for both intensity and geometry measures. Results: Based on the phantom and micro-CT data, the proposed method provides thickness estimates of cortical thin-bone features (0.25 - 0.8mm thick) to within 12% of their true thickness. This compares to >100% thickness overestimation and intensity underestimations errors observed for thin-bones by threshold segmentation of the original CT images. Conclusion: The presented method is a viable means of correcting for the typically observed thickness overestimation and intensity underestimations of sub-millimetre cortical thin-bone features. This provides a significant enhancement in resolution of CT values, which can be used to improve segmentation of clinical CT scans. Consequently, this will have a direct impact on the accuracy of CT based patient specific FE models containing thin-bones, such as the craniofacial skeleton, scapula and pelvis. Future work will extend this algorithm to improve accuracy in stratification of cortical shell/trabecular bone structures. 18: Comparison of Outcomes and Survivorship Between Patients of Different Age Groups Following Total Knee Arthroplasty Christopher E Robert, ON; James L Howard, ON; Douglas Naudie, ON; James P McAuley, ON; Richard McCalden, ON; Robert B Bourne, ON; Lyndsay Somerville, ON; Steven JM MacDonald, ON Purpose: Total knee arthroplasty is being performed with increasing frequency in younger patients. The literature has demonstrated that patient satisfaction correlates with clinical outcomes according to the KSS, WOMAC and SF-12. The purpose of this study was to evaluate and compare the survivorship (5 and 10 year) and clinical outcomes of patients of different age groups that underwent TKR at our institution. Method: A retrospective review based on a prospective database was performed on 6,708 consecutive patients that underwent primary TKA between January 1996 to December 2009. Patients were then divided into 3 groups based on their age: <55, 55-70 and >70 years. Clinical outcomes were assessed using the WOMAC, SF-12 and Knee Society Score (KSS). The outcome score change was determined by subtracting the preoperative score from the most recent available postoperative score. The outcome score change was then compared between the 3 age groups. Kaplan-Meier analysis was performed on each group of patients to calculate survivorship at 5 and 10yrs with revision for any reason being the endpoint. Results: Comparing the <55, 55-70 and >70 age groups respectively, there was a statistically significantly difference in the WOMAC total change score (32 vs 31 vs 26, p<0.0001). This pattern of change was also found when the WOMAC was broken down into its subscales including pain, stiffness and function. There was also a statistically significant difference in the change in Knee Society Score favoring the younger populations (<55rys: 78.9 vs 55-70yrs: 76.0 vs >70yrs: 69.0). The Kaplan-Meier survivorship for the <55, 55-70, and >70 years age groups at 5 years was 95.5%, 97.2% and 98.1% and at 10 years was 92.2%, 95.9% and 97.6% respectively. Revision secondary to infection was the most frequent cause for failure in all groups. Conclusion: This study has shown that younger patients experience better clinical outcomes following TKA according to the KSS, WOMAC and SF-12, but lower survivorship, when compared to older patient populations. TKA is an excellent treatment for arthritis of the knee even in younger patients. 19: Inconsistencies between Navigation Data and X-rays in Total Knee Arthroplasty are System Dependent. Alberto Carli, QC; Avishai Reuven, QC; Josue Yang, QC; Yaron Brin, QC; John Antoniou, QC; David Zukor, QC Purpose: Computer assisted Orthopaedic Surgery for Total Knee Arthroplasty (TKA) has been shown to improve limb alignment and implant position compared to conventional TKA. Positioning of implants during image free navigation surgery is guided by a digital model formulated from computer software tracking bony landmarks specified by the surgeon. Previous work by our group revealed that inconsistencies exist between intraoperative navigation alignment data and post-operative weight bearing x-rays. The purpose of the current study was to determine if such inconsistencies were software dependent and if utilizing an alternative image free navigation system changed the incidence of significant implant misalignment. Method: Two cohorts of consecutive patients underwent unilateral TKA by a single surgeon using intraoperative navigation. For each cohort, comprising of fifty-eight and thirty-one patients respectively, a different commercially available image-free computer assisted navigation system was utilized. Final intraoperative implant alignment data was collected prospectively and the following three parameters were retained for analysis: 1) the final mechanical axis of the operated extremity; 2) the coronal angle of the tibial implant; 3) the coronal angle of the femoral implant. This intraoperative data were then compared to the same three parameters retrospectively measured from full length lower extremity weight bearing xrays taken six-weeks following surgery. Values taken from digital x-rays in their native DICOM format were measured by two individuals who did not participate in the surgical procedures. Comparisons between navigation and x-ray measurements were made with paired T-tests. Significant misalignment was defined as greater than 3 degrees in at least one of the three measured parameters. Results: All patients underwent surgery and successfully completed their postoperative weight bearing x-rays. In the first cohort, a statistically significant difference was found in the coronal angle of the tibial component measured from intraoperative data compared to weight bearing x-rays (p = 0.04). No significant difference was found for the mechanical axis or the coronal angle of the femoral component. In the second cohort, utilizing a different navigation system, a significant difference was found versus x-rays for both the mechanical axis (p<0.01) and coronal tibial angle (p<0.01). Furthermore, more patients with measurements indicating significant misalignment were found in the second cohort (32%) compared to the first (24%). Conclusion: Deviations between intraoperative navigation data and postoperative weight bearing x-rays differ between different commercially available image-free navigation systems. Such deviations can affect the incidence of significant misalignment in the mechanical axis and coronal angle of the femoral implants and can potentially affect clinical outcome. 20: Long Term Survivorship of the AMK and Genesis II Total Knee Replacement With a Minimum 10 Year Follow-up: A Comparative Analysis Darryl Collings, ON; James L Howard, ON; James P McAuley, ON; Douglas Naudie, ON; Richard McCalden, ON; Steven JM MacDonald, ON; Robert B Bourne, ON Purpose: Since the first modern total knee arthroplasty (TKA) in 1972, there have been numerous implant designs. Two such implants, the AMK (Depuy, Warsaw, IN) and Genesis II (Smith and Nephew, Memphis, TN) have been used extensively in our institution. The purpose of this study was to compare the long-term survivorship of the AMK and Genesis II TKA. Method: Between 1988 and 2000, 709 Genesis II and 1074 (659 cemented) AMK primary total knee replacements (TKA) were performed on 604 and 843 patients respectively. Ethics approval was obtained and a retrospective chart and database review was performed. Demographics, TKA indication, KSCRS, SF-12, and WOMAC outcomes were collected. Revision rate, reason for revision, and KM survivorship curves were calculated using SPSS software. Mean pre-and post-operative KSCS, SF-12 and WOMAC were also compared, as well as the change in score for each group. Results: In the Genesis II group, pre-operative diagnosis was osteoarthritis in 665 (93.79%), inflammatory arthritis in 33 (4.65%), and other 11 (1.55%). At 10-15 years, 20 revisions (2.8%) were performed. The most common reason for revision was infection, at nine (1.3% overall, 45% of revisions). Excluding infections, Kaplan-Meier survivorship at five and 10 years was 99.1% (95% CI 98.7-99.5), and 98.3% (95% CI 97.8-98.8) respectively, with no revision performed beyond nine years. In the AMK group, pre-operative diagnosis was 590 (89.5%) osteoarthritis, 54 (8.2%) inflammatory arthritis, and 15 (2.3%) other. At 10-22 years, 50 (7.6%) revisions were performed in the cemented AMK group, p<0.001. The most common reason for revision was aseptic loosening (1.2% overall, 25% of revisions). Eight revisions were performed for infection (1.2%), p = 0.926. Kaplan-Meier survivorship at five and 10 years was 97.8% (95% CI 97.2-88.4), and 95.1% (95% CI 94.2-96.0) respectively, with no revision performed beyond 13.5 years. Overall Kaplan-Meier distribution was statistically different between the two groups, p<0.001. Conclusion: These results support the hypothesis that there is a lower overall revision rate and less component related failure with the Genesis II total knee arthroplasty implant compared to the AMK total knee arthroplasty implant. 21: Medial vs. Lateral High Tibial Osteotomy Converted to Total Knee Arthroplasty: A Comparison of Outcomes Stephen Preston, ON; James L Howard, ON; Douglas Naudie, ON; James P McAuley, ON; Richard McCalden, ON; Steven JM MacDonald, ON Purpose: High tibial osteotomy (HTO) has long been accepted as an effective treatment for unicompartmental osteoarthritis of the knee in young, active adults. Traditionally, HTOs were completed using a lateral closing wedge technique. However, in recent years medial opening wedge HTO have become more popular. Over time, some HTOs fail and require conversion to Total Knee Arthroplasty. The aim of this study was to compare the outcomes of total knee arthroplasty in patients having previously undergone either medial opening wedge or lateral closing wedge HTO. Method: A review of our institutional database was conducted to identify all patients having undergone a medial closing wedge HTO with subsequent conversion to total knee arthroplasty. A total of 76 converted medial opening wedge HTOs were identified with mean follow-up of 59 months. We then extracted a matched cohort of 76 lateral closing wedge HTOs converted to total knee arthroplasty with a mean follow-up of 71 months. The cohorts were matched for age and year of surgery. SF-12, WOMAC, Knee Society Scores and survivorship at five years were compared between the two groups. Statistical analysis was completed for each variable using Independent Samples T-tests. Results: No statistically significant difference was found in post-operative SF-12 scores between lateral closing wedge HTO and medial opening wedge HTO groups (p = 0.63 for Mental Component Scale and p = 0.93 for Physical Component Scale). Similarly, no statistically significant differences were found in WOMAC or Knee Society Scores between the two groups (p = 0.92 and p = 0.74 respectively). Finally, no statistically significant difference was found in survivorship between the two groups at 5 years. Conclusion: These results suggest that there is no difference in clinical outcomes of total knee arthroplasty in patients having previously undergone medial opening wedge or lateral closing wedge HTO. 22: Migration of hydroxyapatite-coated uncemented tibial components in a multi-center RSA study Elise Laende, NS; Allan Hennigar, NS; Glen Richardson, NS; Dermot Collopy, NS; Michael J Dunbar, NS Purpose: Uncemented total knee replacements have been purported to provide better longterm fixation in younger and more active patients. Surface coatings on uncemented tibial components are often employed with the aim to enhance fixation, but the evaluation of such interventions require in vivo testing. Evaluation with radiostereometric analysis (RSA) can assess implant fixation in a small sample of patients in a much shorter time period than conventional survivorship studies. The purpose of this multi-centre study was to use RSA to evaluate the fixation of uncemented tibial components with a surface coating of hydroxyapatite applied in a proprietary manner. Method: Thirty-one patients were recruited in a consecutive sample survey of patients undergoing total knee arthroplasty in Halifax, Canada (n=16) and Perth, Australia (n=15) using the same inclusion/exclusion criteria and receiving the same uncemented implants (Periapatite-coated Triathlon Total Knee, Stryker Orthopaedics) with the same surgical approach. During surgery, eight tantalum markers, one millimetre in diameter, were inserted into the proximal tibia. Using a calibration box, stereo RSA radiographs were taken postoperatively and then again at six weeks and three, six, 12 and 24 months following surgery. Health status and functional outcome measures, including accelerometric gait analysis, were recorded to quantify functional status of subjects before surgery and at each follow-up interval. Results: The patients recruited at the two centers were of the same age group (66±6.2 years) and weight (88±15 kg), but differed in height (Halifax: 168±9.2 cm, Perth: 178±8.3 cm; p value = 0.004), BMI (Halifax: 31±4.7 kg/ m2, Perth: 27±2.9 kg/m2; p value = 0.005), and tibial component size (Halifax: mean size 4, Perth: mean size 6). The Oxford Knee functional score differed for the two centers pre-operatively (Halifax: 41±7.7, Perth: 31±7.6; p value = 0.003). In Halifax there was one revision for aseptic loosening at 14 months. The migration of this implant was 12.5 mm at 1 year. Excluding the revised case, the migration results at one year, calculated as maximum total point motion (MTPM), were 1.31±1.25 mm for Halifax and 0.58±0.26 mm for Perth (p value =0.06). The clinical precision of the MTPM metric is 0.12 mm, calculated as the standard deviation of measurements made from double exams of all patients. Conclusion: The initial migrations in all but one patient are comparable with other uncemented designs suggest general good initial fixation, but long-term monitoring of migration will continue. The early revision in one patient suggests that the indications for uncemented fixation still need refinement. Multi-center recruitment is valuable for obtaining a diverse patient population and ensuring the success of an implant design across a more representative global group. 23: No difference in health and activity-related quality-of-life outcomes after mobile and fixed bearing medial unicompartmental knee replacement Bas A Masri, BC; David J Biau, BC; Nelson V Greidanus, BC; Donald S Garbuz, BC Purpose: Health and activity-related quality-of-life outcome differences between mobile and fixed-bearing unicompartmental knee replacement have been poorly studied. We propose a comparison of mobile versus fixed-bearing unicompartmental knee replacements. First we hypothesized that health or activity-related quality-of-life outcomes would be similar between both groups. Second, we sought for independent predictors of health or activity-related qualityof-life outcomes. Method: Patients who underwent a medial UKR were identified from a prospectively collected database. Demographic data, pre- and postoperative outcomes including the SF-12, WOMAC, Oxford, self-administered patient satisfaction scale, and UCLA activity level score. Outcomes were compared at baseline and last followup. Univariable and multivariable regression models were used to seek for independent predictors of these outcomes. Results: 104 knees (90 patients) with more than 2 year followup were identified, 37 with a mobile bearing and 67 with a fixed bearing. At baseline, patients were comparable for sex, height, and outcome measures. Patient in the mobile-bearing group were however significantly younger and heavier than those in the fixed-bearing group. There was no statistical difference at baseline between the mobile and fixed groups in the Oxford, WOMAC, and SF-12 (pcs and mcs). At minimum 2 years followup, the groups differed statistically only in the postoperative Oxford normalized score: the median Oxford-12 was 79 (Q1-Q3: 73-90) and 90 (Q1-Q3: 81-96) in the mobile-bearing and fixed-bearing group respectively (P = 0.049). There was no other statistically significant difference between both groups. The design of the component was significantly associated with the SF-12 pcs at last followup: patients with a fixed-bearing design had on average, after adjustment, a score 6 points inferior to those with a mobile-bearing (P = 0.024). There was no evidence of association between the design and the Oxford-12 (P = 0.43), the global WOMAC (P = 0.73), the SF-12 mcs (P = 0.95), the overall SAPSS (P = 0.47), or the UCLA (P = 0.4). Scores at baseline were always predictive of scores at last followup. Older patients were more likely to have lower SF-12 mcs (P<0.001) and UCLA (P<0.001); patients with higher BMI were more likely to have lower WOMAC (P = 0.024); and women were more likely to have lower UCLA (P = 0.0043). Conclusion: There is no evidence for a significant effect of the bearing design after medial unicompartmental knee replacement on health or activity-related quality-of-life outcomes. Other demographic variables and baseline score values have, however, a determinant effect. Given the absence of other proven long-term clinical benefits of the mobile-bearing design and the inherent technical difficulties associated with this design, we recommend using fixedbearing unicompartmental knee implant for the treatment of anteromedial osteoarthritis. 24: Oxford Phase 3 Medial Unicompartmental Knee Arthroplasty: Clinical and Radiographic Results of 463 knees at a Canadian Center Rajesh Nair, BC; R Stephen J Burnett, BC; Duncan Jacks, BC; Christine Hall, BC; Megan McAllister, BC Purpose: Unicompartmental knee arthroplasty (UKA) is frequently performed in the treatment of isolated medial compartment osteoarthritis (OA) in patients with anteromedial OA and an intact ACL with favourable results. The results of this implant and technique have been reported by the implant designers and by non-implant –design centers with different clinical outcomes in the literature utilizing similar indications and surgical technique. A retrospective study was undertaken at a Canadian center to assess the clinical and radiographic outcomes of 463 consecutive Oxford Phase 3 mobile bearing medial UKA. This study is the largest nonimplant designer cohort reported to date. Method: A retrospective review of 463 consecutive Oxford medial Phase 3 UKA’s (382 patients) was performed at a single Canadian tertiary care center over a 10-year period. Patients were followed clinically and radiographically and no patients were lost to follow-up. All patients were evaluated at most recent follow-up by an independent surgeon other than the treating surgeon. Outcome measures included: Knee Society Clinical Rating Score (KSCRS), Oxford Knee Score, WOMAC, SF-12, reasons for revision and reoperation, radiographs including mechanical axis alignment, and patient satisfaction. A comprehensive statistical analysis including predictors of failure and reoperation were performed by a statistician. Results: The mean age at surgery was 69 years (range, 38-88). There were 218 women (57%) and 164 men (43%). At a mean follow-up of 3.9 years (range, 0.1-8.3), the final WOMAC score was 82, SF-12 physical score was 47 and mental score was 51. The overall reoperation rate was 6.7% (31 knees). Twenty-three knees were revised to TKA at a mean of 35.6 months (range, 7-92) most commonly for progression to lateral compartment OA (10 knees). Eight knees were revised for tibial loosening, four for femoral loosening, and one for PCL failure. Five further knees were deemed a failure and are pending revision to TKA for an overall revision rate of 6.1% (28 knees). Three knees underwent polyethylene liner exchange for bearing dislocation and two knees had further arthroscopic procedures. Improvements in preoperative compared to postoperative scores for ROM KSCRS Pain and Function, and Oxford Knee Scores were significant (p<.05). Overall 92% of the patients were extremely or very satisfied with the outcome and 96% would have the procedure again. Conclusion: UKA surgery with the medial Oxford Phase 3 implant is associated with high patient satisfaction and a favourable revision rate at medium term. Progression to lateral compartment OA was the most common reason for revision. Predictors of failure included: over correction to a valgus mechanical axis, thickness of the polyethylene, and thickness of tibial bone resection. The results of this study are similar to those reported by the implant designers utilizing the same selection criteria and implant design. 25: The Addition of Antibiotics to Cement Does Not Appear to Lower the Risk of Early Revision in Knee Replacement Surgery Eric R Bohm, MB; Jing Gu, ON; Naisu Zhu, ON; Nicole De Guia, ON; Tammy Anderson, ON; Claire Marie Fortin, ON; Michael J Dunbar, NS Purpose: There exists considerable debate around the usefulness of adding antibiotics to cement for the fixation of total knee replacement (TKR) implants. While antibiotics offer the theoretical benefit of lowering the risk of early revision due to infection, no study has definitively determined if this is true. Conversely, the addition of antibiotics may have an unintended negative impact on the mechanical properties of the cement, and in fact result in a higher revision rate. We sought to answer this question by examining data from both the Canadian Joint Replacement Registry (CJRR), and the hospital morbidity database (HMDB) which contains detailed information on all hospital stays in Canada. Method: We identified 36 681 patients with the diagnosis of degenerative arthritis who had their cemented primary TKR appropriately recorded in both CJRR and the HMBD (linkage rate 77%). The HMBD was then queried to ascertain if a revision had been performed in the 2 years following the primary TKR. If a revision was identified, the CJRR was queried for further information on the exact reason for revision. In addition to the presence/absence of antibiotics in the cement, other variables considered in the analysis included age, gender, comorbidities (Charlson index), and the presence of diabetes. Results: 16 665 patients had their TKR inserted using antiobiotic containing cement, while 20 016 patients had their TKR inserted without antibiotics in the cement. Revision occurred in 532 patients, representing an overall 2 year revision rate of 1.45%. This reflected a revision rate in the antibiotic group of 1.51%, and in the non-antibiotic group of 1.40%, p=0.41. CJRR data on the exact reason for revision was available for 206 of these 532 patients (38.7%). Twice as many patients were recorded as being revised for aseptic loosening in the non antibiotic group than the antibiotic group (p=0.02), however reported rates of revision for infection or pain of unknown origin did not differ between the groups. When controlling for the presence of diabetes, comorbidity index, age and gender, the hazard ratio of revision in the antibiotic cement group was 1.066 [95% CI 0.90 – 1.27, p=0.46] compared to the non antibiotic group. Conclusion: It appears that the addition of antibiotics to cement for TKR has no clinically important effect on the risk of revision within 2 years of surgery. Longer follow up, as well as confirmation of these findings with other national registries is warranted. 26: The Fate of the Remaining Knee(s) or Hip(s) in Osteoarthritic Patients Undergoing a Primary TKR or THR Steven JM MacDonald, ON; Douglas Naudie, ON; Richard McCalden, ON; James P McAuley, ON; James L Howard, ON; Robert B Bourne, ON Purpose: The natural history of osteoarthritis remains unclear due to its multifactorial etiology. The long term influence of total joint replacement in one of the four large joints in lower limb to the remaining unreplaced three has seldom been fully evaluated in osteoarthritic patients. We seek to determine the incidence of a second total joint replacement after the initial THR or TKR in a large, long-term cohort of patients, the pattern and the influence factors of a second arthroplasty, and the yearly cumulative risk of undergoing a second replacement following the first THR or TKR. Method: A prospective total joint replacement database was employed to identify osteoarthritic patients who received a primary hip or knee replacement with more than ten years follow-up. This patient cohort was then followed to determine the information of a subsequent total knee or hip replacement. Results: Five thousand, three hundred and fifty two idiopathic osteoarthritic patients treated with a total hip or knee replacement were followed a mean 17.8 ± 5.7 years. Forty six percent (n=1341) of the 2917 initial total knee replacement patients underwent a contralateral procedure, it was 30.5% (743/2435) in the hip site. The time interval between two successive total joint replacements was shorter in the knee-to-knee group (3.05 ± 3.46 years) than in the hip-to-hip group (4.60 ± 4.74 years). After the first total joint replacement, the contralateral paired joint was the most likely joint to be replaced next, followed by the ipsilateral hip or knee joint, then the contralateral unpaired one. Multivariate analysis revealed risk factors for needing a second arthroplasty were higher body mass index and younger age in knees, and overweight status in hips. Hazard analysis showed higher yearly cumulative risk of having a second procedure following the first total knees as compared to total hips. 27: Two-stage revision total knee arthroplasty with an articulating spacer: Minimum five-year review Edward M Vasarhelyi, ON; James L Howard, ON; Douglas Naudie, ON; Richard McCalden, ON; Steven JM MacDonald, ON Purpose: The purpose of the current study is to review the minimum 5-year results of twostage revision total knee arthroplasty with articulating spacers for chronically infected total knee arthroplasty, and secondarily, compare these outcomes with those performed with nonarticulating spacers. Method: A total of 106 patients presenting to a tertiary care arthroplasty service with an infected total knee arthroplasty that was deemed most appropriately treated with a two-stage revision arthroplasty were prospectively enrolled. Patients were retrospectively reviewed based on the type of spacer used during their first-stage revision; 60 patients were treated with articulating spacers, while 46 were treated non-articulating spacers. Prospective data was collected on each patient including demographic information, KSS, WOMAC and SF-12 scores. The scores were obtained prior to revision surgery as well as annually as part of their standard follow up clinical review. In addition, data on need for subsequent surgery was collected on each patient. Results: The articulating and non-articulating spacer groups were well matched on age, BMI, gender and side of surgery. There were statistically significant improvements in all components of the KSS (p <0.001), WOMAC pain (p =0.02), stiffness (p=0.05) and function (p=0.001) when comparing post-operative to pre-operative scores. There were no differences in the SF-12 mental component score and was a trend towards significance on the physical component score. Survivorship of revision total knee arthroplasty that were initially treated with articulating spacers at 5 years for all causes and aseptic loosening was 88.1% and 91.3% respectively. When comparing articulating and static spacers, knees treated with articulating spacers obtained an average range of motion of 100 degrees in comparison to 84 degrees for the static spacers (p=0.009). Conclusion: Two-stage revision arthroplasty with articulating spacers for chronically infected total knee arthroplasty resulted in successful eradication of infection in 91.3% of patients at five years. There were statistically significant improvements in post-operative KSS and WOMAC scores with articulating spacers. The use of articulating spacers result in an improved range of motion when compared to two-stage revision arthroplasty performed with static antibiotic spacers. 28: Does Total Ankle Replacement Have an Affect on the Development of Peri-talar Joint Arthritis? 28 - 0900 Does Total Ankle Replacement Have an Effect on the Development of Peri-talar Joint Arthritis? Steven JM MacDonald, ON; Josh Mayich, ON; Walter Mak, ON; Timothy Daniels, ON Purpose: With the retained motion at the ankle in total ankle replacement (or TAR) it has been theorized that the subsequent development of degenerative arthritis in the subtalar and talonavicular joints would be significantly less than what is commonly seen post ankle fusion. Although this has been commonly quoted as an advantage of TAR over fusion, it has not been well substantiated. Furthermore, the method used to assess arthritis of the peritalar joints (or PTJ), the Kellgren & Lawrence scale (or KLS), has never been validated for the PTJs. The primary purpose of this study was to assess the progression of radiographic arthritis of the PTJs. The secondary purpose was to assess the usefulness of the KLS for the measurement of arthritis in the PTJs. Method: 60 TAR were performed from 2001 to 2006, and have had a minimum of 5 years of follow up. Pre-operative and post-operative radiographs of all patients were obtained. Of those 60 ankles, 43 did not have any ancillary surgery to fuse either of the PTJs at the time of the initial TAR surgery. These patients were followed a minimum of 5 years. Three independent reviewers analyzed all radiographs using the KLS for osteoarthritis. Interobserver analyses were performed to analyze the consistency of measurement between observers. Results: For the subtalar joint, mean pre-operative scores were 1.5+/- 0.5. Post-operatively scores were 1.8 +/- 0.6. This represented an average advancement of arthritis of 0.3 grades. For the talonavicular joint, the preoperative mean of 1.3 +/- 0.2 increased to 1.6 +/- 0.3 postoperatively. This represented an increase of 0.26 grades. Neither change represented a statistically significant difference. (p = 0.97, and 0.45; respectively) Unfortunately, the KLS showed very low inter-observer consistency. For the subtalar joint, a percentage agreement of 44% and K of 0.25 was shown. Somewhat more encouraging was the 78% agreement, and K of 0.7 for measurement of the talonavicular joints. Conclusion: The results of this preliminary research seem to show that in the post-TAR setting, there is no significant development of arthritis of the peri-talar joints at five years. The KLS; however, has been demonstrated to have questionable value in the measurement of PTJ, specifically the subtalar joint. 29: A Finite-element Analysis Study of the First Metatarsophalangeal Joint of the Hallux Rigidus Presenter: Robert Flavin, IE, David FitzPatrick, IE; Michael Stephens, IE Purpose: Hallux rigidus was first described in 1887. Many aetiological factors have been postulated, including tight Achilles Tendon, Metatarsus Primus Elevatus and articular surface mismatch, but none has been supported by scientific evidence. Method: We have examined the static and dynamic imbalances in the first metatarsophalangeal joint which we postulated could be the cause of this condition. We performed a finite-element analysis (ABAQUS) study on eight male subjects and calculated a mathematical model of the joint. Each model was defined in the elastic phase of the viscoelastic property of the model. Each model consisted of approximately 300,000 nodes and over 200,000 tetrahedral elements. The models were subjected to both normal and abnormal physiological loads, including increased tensions (1); in the medial band of the plantar fascia, (2); the long and short flexors and (3); simulated an articular surface mismatch. Results: The results gave statistically significant evidence for an increase in tension of the medial band of the plantar fascia as the cause of abnormal stress on the articular cartilage rather than mismatch of the articular surfaces or subclinical muscle contractures. The graphical representation of the stress on the metatarsal head showed over a 100% increase in the stress on the cartilage of the metatarsal head with the increased stress primarily located over the dorsal surface compared to physiological conditions, (7.3GPa vs 3.6GPa, p<0.05) The increased tension in the Flexor Hallicus Brevis and Longus showed approximately 25% increase in the stress on the cartilage of the metatarsal head however this increase was distributed evenly through the FROM, (4.4GPa vs 3.6GPa, p>0.05). The simulated articular surface mismatch demonstrated highly abnormal metatarsal head stresses on the first cycle which resulted in a fracture. Conclusion: Our study indicated a potential clinical cause of hallux rigidus and challenged the many aetiological theories. It could influence the choice of surgical procedure for the treatment of early grades of hallux rigidus. A postulated treatment is a cheilectomy with a dorsal Moberg osteotomy to indirectly simulate a medial band plantar fascia lengthening procedure. 30: Anatomic Reduction of the Sydesmosis: What Values Can we Trust? Jonah Hébert-Davies, QC; Marie-Lyne Nault, QC; G Yves Laflamme, QC; Stephane Leduc, QC; Dominique M Rouleau, QC Purpose: Anatomic reduction of the fibula with regards to the tibia has become the goal of treating syndesmotic injuries. Several studies have recently questioned our capacity to do so, implying that malreduction is much more common then originally thought. These studies focus on post-operative CT scans to show wide-ranging variation. Our hypothesis is that there exists a wide range of anatomical variation in the syndesmosis and this might lead to overly critical opinion of post-reduction CT scans. The purpose of this study is to first identify radiological measurements to evaluate the syndesmosis and establish normal values. Method: Ankle CT scans of 100 normal ankles were evaluated. These scans had been done to evaluate patients with foot trauma but without documented ankle trauma. A series of eight measurements was then devised with some based on previously published studies and modified by our group. These criteria measure both position of the fibula and rotation with regards to the tibia. Two independent reviewers evaluated all scans and all measurements were recorded initially and again at 6 weeks. Results: We found that the most useful and reproducible measurement was rotation index, as defined by the ratio of the posterior and anterior gaps between tibia and fibula. All results were reproducible with excellent intra and inter-observer reliability with interclass correlations between 0.8 and 0.99. On average we found that the fibula was 2mm (range 0-4mm) eccentric posteriorly on axial CT-Scan views. Also, on average the fibula was externally rotated 10 degrees (range 3-13.) Conclusion: Several studies have shown that reduction of the syndesmosis is essential to restore normal ankle mechanics and prevent secondary degenerative changes. Our results show that a significant amount of variability exists in the anatomical position of the syndesmosis. The evaluation criteria developed in the study can give the surgeon a guideline for evaluating post-operative reductions without having to scan a contralateral ankle. 31: COFAS Multicenter Study Comparing Total Ankle Arthroplasty and Ankle Arthrodesis: Mid-Term Results Timothy Daniels, ON; Mark A Glazebrook, NS; Alastair SE Younger, BC; Murray John Penner, BC; Kevin J Wing, BC; Hubert Wong, BC; Peter Dryden, BC; Trish Francis, NS; Biraj Bora, BC; Ellie Pinsker, ON Purpose: Summary: A prospective, multicenter study compared the outcomes of 242 total ankle arthroplasty (TAR) and 95 ankle arthrodesis (AA) patients at mean follow-up of 4.9 years. AOS and SF-36 PCS and MCS scores improved and were not significantly different across the TAR and AA groups at final follow-up. Twenty-two patients (19 TAR, 3 AA) underwent revision surgery. TAR is comparable to AA for the management of end-stage ankle arthritis, with a higher revision rate in the TAR group. To present the mid-term results of a prospective, multicenter total ankle arthroplasty and arthrodesis database. Method: Between November 2001 and July 2007, patients were recruited by 4 surgical centers across Canada and underwent either ankle arthroplasty (TAR) or ankle arthrodesis (AA). Patient characteristics collected included demographics, comorbidities, and diagnoses. Surgical data gathered included implant type, concurrent procedures, complications, and revisions. The primary outcome measure was the Ankle Osteoarthritis Scale (AOS). Secondary outcome measures were Short Form-36 (SF-36) scores and revision rates. Revision rates with exchange or extraction of components as endpoint were calculated for TAR patients. For AA patients, revision was defined as any surgery required to correct malunion, non-union, or persistent symptoms, and amputation events. Linear mixed effects models were used to compare the difference between the TAR and AA groups in AOS and SF-36 outcomes at final follow-up, with adjustment for baseline characteristics. Results: Of 372 patients enrolled in the study, complete records for 337 patients (90.5%) were available for analysis. These included 242 TARs and 95 AAs with a mean follow-up of 4.9 years. The two groups were similar for sex (TAR: 53.2% male; AA: 60.9% male), BMI and operated side. The TAR group was significantly older (62.8 ± 11.0 years; AA: 54.6 ± 11.6 years; p<0.001) and had a higher rate of inflammatory arthritis (p=0.001). Diabetes and smoking during the 12 months prior to surgery were more prevalent in the AA group (p=0.05 and p=0.01, respectively). AOS and SF-36 scores improved in TAR and AA patients following surgery (Table 1). Baseline AOS scores and SF-36 PCS scores were similar for the two groups. Baseline SF-36 MCS scores were slightly lower in the AA group (p=0.03). After adjustment for baseline characteristics and baseline AOS score, average AOS scores at final follow-up were not significantly different across the two groups (1.7 units higher in the TAR group; 95% CI: -4.6, 8.0). Similarly, after adjustment for baseline characteristics and baseline SF-36 scores, average SF-36 PCS and MCS scores at final follow-up were not significantly different across the TAR and AA cohorts (PCS: 1.1 units higher in the TAR group; 95% CI: 2.0, 4.3; MCS: .07 units lower in the TAR group; 95% -2.7, 2.6). Twenty-two patients underwent revision surgery. Three AA patients required revision, all within the first 2 years following surgery. A total of 19 TAR patients underwent revision, from 1 month to 7 years after surgery. Conclusion: This is the first longitudinal multi-centered clinical study comparing the intermediate results of TAR to AA. Validated outcome scores indicate that TAR is comparable to AA for the management of end-stage ankle arthritis with a higher revision rate in the TAR group. Further work is required to identify the advantages and disadvantages of each procedure. 32: Mechanical Adaptation and Density Distribution of the Subchondral Bone Plate After Supramalleolar Osteotomies for Asymmetric Ankle Osteoarthritis Christian Egloff, CH; Geert Pagenstert, CH; Victor Valderrabano, CH; Magdalena MüllerGerbl, CH Purpose: Increasing evidence suggest that subchondral bone mineralization changes are associated with progressive Osteoarthritis. Joint preserving surgery (JPS) revealed encouraging results in reducing pain and improving subjective and objective function of patients with asymmetric ankle degeneration. However, the biological effects and efficiency of unloading surgery on the subchondral bone plate was not studied on molecular level, based on density distribution. The purpose of this study was to evaluate and measure the density distribution and mechanical adaptations of the subchondral bone plate of the distal tibia and talus after supramalleolar osteotomies in patients with asymmetric ankle osteoarthritis using CT-Osteoabsorptiometry (CT-OAM). Method: We prospectively followed 14 consecutive patients between January 2006 and May 2008 with posttraumatic valgus ankle OA treated with supramalleolar osteotomy for JPS. We included only patients younger than 65 years and with a follow up time longer than 12 month. Of the remaining eight patients (six males, two females), all ankles (three right ankles, five left ankles) were examined by a single slide CT scanner before and after JPS. The average follow up time was 16 month, ranging from 13 to 24 months. The average age was 43 years, ranging from 19 to 65. By means of CT-Osteoabsorptiometry (CT-OAM), the distribution of mineralization on the subchondral bone plate of all distal tibiae and talus were analysed using a standardized coordinate system with 15x20 gridlines to localize maximums of bone density throughout the joint. All the left joint surfaces were point reflected so only right ankles were analysed. Subchondral bone pixels were segmented and assigned to 10 density value groups (Δ100 HU, range 200-1200 HU) using volume rendering technique (VRT). Results: The subchondral mineralization distribution revealed considerable topographic changes before and after JPS on the talar and less on the tibial articular surface. Areas of greatest density in valgus ankle OA were found in the peripheral zones predominantly on the lateral side. After JPS, regions of maximal density eased and a more evenly spared distribution was observed. Conclusion: Our results showed characteristic changes in mineralization distribution patterns of the subchondral bone plate before and after JPS of posttraumatic valgus OA. We believe these data can serve as a verification of the efficacy of JPS for patients with asymmetric ankle OA. 33: Peroneal Tendons Plasty for Lateral Instability of the Ankle: A New Surgical Technique Roberto Somellera, MX; Peter A Schulz, DE; Hector Cabrera Palacios, DE; Michael Maru, UK Purpose: The pronation and supination of the ankle joint gives the human a very unique weight bear. This is shown in the ability for walking on uneven surfaces, climbing and dexterity for performing sports. The stability of the ankle joint is not only provided by the anatomical configuration of the tibia, fibula and talus within the mortise but by the combined function of ligaments and muscles too. The chronic instability of the ankle precedes chronic pain, disability for daily living activities and leisure sports. This is a direct consequence of ligamentous injuries as well as elongation and dysfunction of the peroneal tendons. The main reason for surgical reconstruction is chronic instability. The objectives of this study were to analyse the clinical outcomes and complications of this new surgical technique and to compare the results with other procedures described in the literature. Method: We operated with this new technique in 83 patients, 15 were not included because were lost for follow up. We included 67 patients in this study, 47 males, 20 females; 44 on the right side and 23 on the left. The average age was 24 years ranging from 14 to 39.The average age of follow up was 3 years ranging from 7 months to 10 yearsWe operated with this new technique in 83 patients, 15 were not included because were lost for follow up. We included 67 patients in this study, 47 males, 20 females; 44 on the right side and 23 on the left. The average age was 24 years ranging from 14 to 39.The average age of follow up was 3 years ranging from 7 months to 10 years resultsWe operated with this new technique in 83 patients, 15 were not included because were lost for follow up. We included 67 patients in this study, 47 males, 20 females; 44 on the right side and 23 on the left. The average age was 24 years ranging from 14 to 39.The average age of follow up was 3 years ranging from 7 months to 10 years results.The surgical procedure starts with longitudinal incision of about 7 cms, starting 4 cms above the tip of the lateral malleolus. The peroneous brevis and longus tendons are identified. A incision over the tendinous part of bout tendons is performed at the same level and 1 cm is excised from the substance of both tendons. The tendons are sutured again with a Bunnel type suture. The wound is sutured by layers. Results: We found excellent results in 88% of the patients, good in 12% and 0% bad results according to the Sefton criteria (Sefton 1979). We had only one superficial infection and painful nodules over the surgical area of the tendon in 25% of the patients after surgery. These nodules disappeared after 6 months. Conclusion: With exellent results in 88% of the patients, good in 12% and low rate of complications this is a further surgical option for the treatment of lateral instability of the ankle joint. This new technique provides a easier surgical approach, preserves better ankle anatomy and biomechanics leading to a lower rate of complications. 34: The Importance of Plasma Sprayed Hydroxyapatite Coating on Titanium Plasma Spray in the Osseointegration of Total Ankle Arthroplasty Implants Presenter: Robert Flavin, IE; Mark Steeves, BC; Murray John Penner, BC; Alastair SE Younger, BC Purpose: The principle mode of failure of Total Ankle Arthroplasty (TAA) is aseptic loosening, or failure of the prosthesis to bond to bone. This may be reflected in bone cyst formation, subsidence, radiographic loosening, poor outcome scores secondary to pain, and revision for aseptic loosening. We hypothesize that the revision rates for a non Hydroxyapatite coated sintered titanium bead ingrowth prosthesis may be higher than a porous coated surface with plasma sprayed titanium and hydroxyapatite flat backed prostheses. Both were mobile bearing in design. In this study we endeavoured to determine if this was a chance observation, or whether a higher revision rate truly existed. Method: We performed a retrospective study comparing the early failure to osseointegrate rate of two popularly used Total Ankle Arthroplasty prostheses, Hintegra (Newdeal SA, Lyon, France) and the Mobility (Depuy International, Leeds, UK). Exclusion criteria were revisions due to infection. Tribological factors, for each patient, for aseptic loosening were standardized to isolate the effect of the different bone – implant geometries and surface coatings. Results: Between 2005 and 2007, thirty-three Mobility TAAs were performed and between 2007 and 2010 thirty-seven Hintegra TAAs were performed. The baseline demographics showed no statistical difference (p-value >0.05). This study demonstrated statistically significant higher revision rates (15.2% vs 2.7%; p-value=0.0477) component loosening rates (as diagnosed by comment at explanation at the revision surgery), clinically and radiographically by SPECT-CT (25.7% vs 5.4%; p-value=0.0095) and symptomatic impingement rates, as diagnosed clinically and radiographically on SPECT-CT (27.2% vs 8.1%; p-value=0.0275). Conclusion: In conclusion, by examining the early osseointegration failure rates of two popularly used Total Ankle Arthroplasty prostheses by isolating the effects of the different bone – implant geometries and surface coatings; we demonstrated a statistically significant failure to osseointegrate in the Mobility TAA group which may be due to either geometry or surface coating. 35: Is Valgus Deformity Greater than Ten Degrees at the Ankle Really a Contraindication to Total Ankle Arthroplasty? Timothy R Daniels, ON; Josh Mayich, ON; Ellie Pinsker, ON Purpose: Total ankle arthroplasty (or TAR) in the setting of coronal deformity is controversial. Historically, coronal deformity over 10 degrees was thought to be a contraindication; however, more recent literature has shown that acceptable outcomes can be achieved. Although varus deformity has been studied, clinical information on the outcomes associated with valgus deformity are lacking. The purpose of this prospective cohort study was to evaluate survivorship of TAR components in the setting of preoperative valgus coronal deformity. A matched cohort of TAR performed in ankles with no coronal deformity was used for comparison. Method: Between 2001 and 2009 consecutive patients with valgus deformity greater than 10 degrees who were willing to undergo TAR were enrolled. A minimum of two-year follow-up was required. A primary outcome of revision of the metal components was selected. Secondary outcomes including re-operation and patient outcome scores, as well as radiographic and clinical data were also collected. Results: 31 TAR in 29 patients met the inclusion criteria. The two-year failure or metal component revision rate was 12.90%. (95% confidence interval [CI] 3.63%–29.83%). The twoyear reoperation rate, which included any operation on the operated foot and ankle that was not a metal component revision, was 9.7% (95% confidence interval [CI] 2.56%–25.7%), with three patients requiring reoperation. This compared unfavourably to the control population. (Revision rate, reoperative rate) The AOS Pain Component decreased by an average of 27.7 ± 23.2 points in the valgus group and 34.7 ± 21.9 in the neutral group (p<0.01). There was no statistical difference in pain improvement between the two groups (p=0.793). The AOS Disability Component decreased by an average of 40.7 ± 18.6 points in the varus group and 38.0 ± 23.8 in the neutral group (p<0.01). There was no statistical difference in pain improvement between the two groups (p = 0.578). Conclusion: Although clinical results from TAR in the setting of valgus can be quite good, the failure rate of TAR in this setting is relatively high. Caution should be used when attempting TAR in valgus deformity, and patients should be counseled appropriately before proceeding. 36: Total Ankle Arthroplasty in the Diabetic Population - Results of a Matched Casecontrol Study using a Prospective Data-base Ines LH Reichert, UK; Ellie Pinsker, ON; Ryan Khan, ON; Timothy R Daniels, ON Purpose: Diabetes mellitus in patients with end-stage ankle arthritis does present the physician with the question if ankle replacement surgery in diabetic patients is associated with higher risk and worse outcome than in the non-diabetic population. Method: At our institution pre-and postoperative data for all patients who undergo ankle replacement is collected prospectively since 2002. We have retrieved the details of all patients with Diabetes Type 2 operated during this time period. Clinic notes and drug charts were examined for evidence of problems with post-operative wound healing, infection or revision and their prospective collected outcome data (AFOAS, SF36) was analysed. Each patient in this cohort was closely matched with a non-diabetic patient taking in account age, gender, type of ankle arthroplasty, aetiology of arthritis and severity of pre-operative ankle deformity (COFAS) and BMI. The ASA, blood sugar, medication and smoking habit were also noted. Results: There were 26 ankle replacements in each group, 24 diabetic (D) and 25 nondiabetic (ND) patients: mean age 65.6 (D), 64.2 (ND); mean BMI 29.4 (D), 30.0 (ND); aetiology of arthritis: RhA (3 D, 3 ND), post traumatic (14 D, 18 ND), OA (9 D, 5 ND); COFAS I (2 D, 2 ND), COFAS II (6 D, 8 ND), COFAS III (5 D, 3 ND), COFAS IV (13 D, 13 ND); type of prothesis STAR (9 D, 10 ND), Mobility (6 D, 6 ND), Hintegra (11 D, 10 ND). The mean follow-up was 3.8 years with a minimum of two years. In all diabetic patients significant peripheral neuropathy or vascular disease had been excluded pre-operatively. The records detailing post-operative clinic follow-up were complete. Five patients in the diabetic and nine patients in the nondiabetic group had wound healing problems, which ranged from mild erythema (2 D, 2 ND), minor stitch abscess (2 D, 1ND), partial dehiscence treated with repeated office debridement for 2-5 months (5 ND) to application of VAC pump (1 ND) and operative debridement (1 D). Re-operation: in the diabetic group two STAR protheses required revision / arthrodesis for catastrophic loosening, 1 Hintegra was revised for pain. One diabetic patient suffered from a chronic pain syndrome prior to surgery and a BKA was performed in spite of a stable prothesis. In the non-diabetic group 2 STAR and 1 Hintegra were revised for loosening and 1 Hintegra (ND) required arthrodesis for late deep infection at two years post surgery. The functional outcome data suggests significant improvement for the AOFAS score for pain and disability for the non-diabetic group but less improvement for the diabetic group. Conclusion: Our study does not confirm an increased risk of infection or revision for the diabetic patient undergoing ankle arthroplasty, when significant peripheral neuropathy has been excluded pre-operatively. However, our results might indicate less improvement in functional outcome for diabetic than for non-diabetic patients, matched for BMI and severity of ankle arthritis. More detailed analysis and larger studies are required. 37: Wound Complication and Infection Rate in Clean First-time Elective Foot and Ankle Surgery - A Retrospective Review Martin Wiewiorski, CH; Thomas Voellmy, CH; Victor Valderrabano, CH Purpose: The aim of this study was to evaluate the rate of wound complications and infection in patients undergoing clean elective first-time surgery of the foot and ankle joint. Method: A retrospective chart review of 298 patients who received elective foot and ankle surgeries between 2006 and 2010 at one hospital clinic was performed. Only those patients who were having elective foot or ankle surgery for the first time, were being followed up at the hospital’s outpatient clinic, had a nontraumatic cause for their surgery and no history of previous infection were included in this study. All surgeries were performed by the senior author. A wound complication was defined as a superficial dehiscence, edema, erythema, or stitch abscess. A wound was considered infected when purulent material from the wound sites was noted and an organism(s) was cultured. All patients received a preoperative antibiotic. Results: In 46 patients (15.4 %) a wound complications was noted. In four patients (1.3%) a wound complication was encountered. Chi square tests and logistic regression models were performed to determine if age, sex, length of stay, type of surgery, surgery time, tourniquet use, antibiotic application time, diabetes mellitus, rheumatoid arthritis and internal fixation were predictive of or associated with postoperative wound infection or complication. Of those factors only rheumatoid arthritis was significantly associated with wound infection (p=0.01, relative risk 20.08). After adjustment of the factors age, surgery time, diabetes and type of surgery only age and surgery time showed a significant association with wound complications (p≤0.001). Conclusion: The results suggest that higher age and prolonged surgery time are the major factors for wound complications in routine elective foot and ankle surgery. 38: A Retrieval Analysis of High Flexion Versus Posterior Stabilized Tibial Inserts Douglas Naudie, ON; Nicholas Paterson, ON; Matthew Teeter, ON; Steven JM MacDonald, ON; Richard McCalden, ON Purpose: High-flexion total knee replacements have recently been introduced to increase range of motion and patient satisfaction, but have not yet been studied in a retrieval analysis in comparison to standard posterior-stabilized tibial inserts. The purpose of the present study was to examine how the design changes between high-flexion and posterior-stabilized tibial inserts would affect their (1) overall damage profile and more specifically the damage on their (2) articular surface, (3) backside and (4) tibial post. Method: We matched 20 retrieved high-flexion inserts to a cohort of 20 posterior-stabilized inserts from the same manufacturer on the basis of duration of implantation, body mass index, and age. Inserts were divided into 16 zones and a microscopic analysis of surface damage was carried out. Several inserts were scanned using micro-CT to further quantify instances of severe post notching. Results: Significantly greater backside (p = 0.01) and post (p = 0.02) damage were found in the high-flexion group, with no significant difference in the articular surface (p = 0.70) or overall (p = 0.18) damage scores. Post notch depths in both high-flexion and posterior-stabilized groups ranged from 0.6 to 1.9 mm. Conclusion: Increased post damage in the high-flexion group suggests a potential susceptibility to post fracture, particularly at higher degrees of flexion where contact stresses are higher. The increased backside damage was unexpected as the two groups have the same tibial component, locking mechanism, and sterilization method. The introduction of a highly crosslinked high-flexion insert will require close scrutiny as a result of the increased strain and potential for post damage demonstrated in this series. 39: Biomechanical effect of Patellar Tendon Recession for Exposures in Knee Arthroplasty Milton Parai, ON; Hakim Louati, ON; Andrew Spiers, ON; Phillippe Poitras, ON; Hani Zamil, ON; Geoffrey Dervin, ON Purpose: Standard medial arthrotomy for total knee exposure may not provide adequate exposure in complex primary and revision surgeries. Release of a portion of the patellar tendon insertion has been compared to osteotomy of the tubercle with comparable results. Specific limits of release and how it affects exposure and strength compared to a native tendon have not yet been defined. Our purpose is to study the effect of partial recession of the patellar tendon and its effect on strength compared to control groups. Method: Paired fresh and single cycle freeze-thawed cadavers were obtained. The test knee was fixed at 90 degrees of flexion and exposed using a standard medial arthrotomy. The insertion of the patellar tendon was identified and 50% of its proximal width was recessed with a taper to an intact inferomedial apex. The knees underwent tensile cyclic loading and load to failure, using a biomechanical axial torsional testing system. Peak load (N) at load to failure was measured. Data was tabulated using a computer spreadsheet program. Results: Eight pairs were obtained to date. Two were unsuitable to test due major structural and degenerative changes. The average decrease in strength was 16% (+/-18%) with range 61-108%. Average load to failure was 3113 N (+/- 1055) in the recession group and 3038 N (+/- 1479) in the control. Median load to failure was 2936 N and 2968 N, respectively. Conclusion: The effect of lowering the insertion strength of the patellar tendon by partial recession was not consistently observed. Though it has been shown to be an acceptable alternative to osteotomy, our study suggests that some strength reduction may occur. This may be an acceptable risk compared to catastrophic failure due to excess tension. Other variables that may affect its strength include the quality of bone and the extent of degenerative disease. Judicious use of this technique could be an acceptable strategy to improve exposure while minimizing excessive and potentially hazardous retraction. 40: Prospective Study On Functional Outcome Of Arthroscopic Drilling Combined With Intra Articular Stem Cell- Hyaluronic Acid Injections Compared To Intra Articular Stem Cell- Hyaluronic Acid Injections Alone Without Arthroscopic Drilling For Treatment Of Ost Ahmed AbdulAmeer Alkhuzai, IQ Purpose: Background: Osteoarthritc knee patients’ grades 2, 3 with disadvantages from the treatments by Hyaluronic acid injection with oral glucosamine-chondroitin were treated by arthroscopic drilling combined with intraarticular injections of Stem Cell-Hyaluronic acid. Aim of study: We studied the effectiveness of combination arthroscopic drilling plus post operative intra articular injection of Stem cell- Hyaluronic acid with oral glucosamine-chondroitin sulfate compared to intra articular injection of Stem cell- Hyaluronic acid with oral glucosaminechondroitin alone without arthroscopic drilling in treatment of grade 2, 3 knee osteoarthritis. Method: In prospective comparative study 32 patients with knee osteoarthritis grade2, 3 disadvantages treated by intraarticular injections Hyaluronic acid plus oral glucosaminechondroitin were randomized according to inclusion exclusion criteria into two groups. Group A 16 patients were treated by arthroscopic drilling with intra-articular injections of stem cell (harvested from patients bone marrow then expanded the cell number), with Hyaluronic acid 25 mg plus oral combination of glucosamine-chondroitin sulfate, the injections done post operative. Compared to group B 16 patients were treated by intra-articular injection of stem cell-Hyaluronic acid 25 mg plus oral combination glucosamine-chondroitin alone without arthroscopic drilling, the patients were followed up for 24 months period. The primary outcome measurements were according to Modified Lequesne's and Modified WOMAC scores. Results: In both groups, A and B significant reduction in the mean of both Modified Lequesne's and Modified WOMAC scores from baseline were seen at all follow up visit for 12, 24 months. Also there were significant statistical differences and clinical improvements at 12, 24 months for both Modified Lequesne's and Modified WOMAC scores in group A superior to the group B (P-value < 0.0001). No severe adverse events related to these combinations were observed. Conclusion: We concluded that arthroscopic drilling with post operative intra-articular injections of stem cell-Hyaluronic acid plus oral combinations of glucosamine-chondroitin sulfate depending on Modified Lequesne's and Modified WOMAC scores for 2 years follow up are superior to intra-articular injections of Stem cell- Hyaluronic acid combined to oral glucosamine-chondroitin alone without arthroscopic drilling. 41: The Effect of Tibial Component Overhang on Medial Collateral Ligament Loads: An In Vitro Robotic Study Ravindra Gudena, UK; Mohammad Atarod, AB; Jason Werle, AB; Cyril Frank, AB; Nigel Shrive, AB Purpose: Tibial implant overhang has been identified as a possible problem in unicompartmental knee replacements (UKR) and to some degree in total knee replacements (TKR). Overhang on the medial side can cause irritation of soft tissues and medial collateral ligament (MCL) impingement. We conducted an in-vitro robotic study to assess the load changes in MCL during passive flexion-extension (PFE) with different amounts of overhang, to define a safe overhang limit. We also investigated the relationship between flexion angle and load changes in the MCL. Method: Six fresh frozen human cadaveric knees were used in this study. The PFE motion was applied to each joint and recorded using a kinematic linkage. The joint was then mounted on a unique 6-DOF parallel robot(R-2000, PRSCo, Hampton, NH, USA, 0.05 mm accuracy) and the previously-recorded PFE was reproduced. All tissues except MCL were removed and the PFE was repeated for 30 cycles while the loads in MCL were recorded simultaneously using a force-moment sensor. Using a coordinate measuring machine, 2mm, 4mm and 6mm overhang placements were marked and the tibial component was successively implanted in the respective positions. For each overhang, the PFE was repeated for 30 cycles and MCL loads recorded. A two-way ANOVA was performed to detect statistically significant effects of overhang and flexion angle on the MCL load. Results: There was no statistically significant load changes in the MCL with 2mm overhang (P=0.15). However, there were statistically significant differences in MCL loads with 4mm and 6mm overhang placements (P=0.036 and P=0.045, respectively). The loads were almost doubled from 2mm to 4mm of overhang. The peak baseline (no overhang) MCL loads found at 90 degrees of flexion in three joints, and in extension in the remaining three, depending on the PFE recorded for each specific joint. This trend was followed even with the overhang. There was no positive correlation between load changes in the MCL and joint flexion angle (P=0.262). Conclusion: Tibial components are available in incremental sizes. In all UKR and TKR systems, undersizing the tibial tray will transfer loads through weak cancellous bone rather than the stronger cortical bone. In this case, using larger implants with an overhang of less than 2mm will avoid the risk of tibial component subsidence. This is the first biomechanical study to investigate the relationship between tibial component overhang and corresponding MCL loads. Our study findings support the previously published retrospective clinical study that indicates no change in UKR outcome scores with tibial implant overhang less than 3mm. We recommend from our study that if the component overhang is greater than 2mm in a symptomatic patient, one should consider revision of the tibial component. Results of this study can also be attributed to the collateral ligaments impingement with osteophytes in an arthritic knee. 42: Two Year Migration in a Randomised Controlled Trial of Fixation with or without Screws for an Uncemented Tibial Base Plate Allan Hennigar, NS; Elise Laende, NS; Michael Gross, NS; Michael J Dunbar, NS Purpose: The option of screw fixation for the uncemented Advance BioFoam Knee Arthroplasty tibial components is available to surgeons, but it is unclear if this augmentation is necessary to achieve stable fixation. The foam metal backed tibial components utilize a porous titanium coating on the underside of the tibial baseplate, intended to promote bone in-growth and provide a more robust bone-implant interface without cement. The addition of up to four titanium screws is also possible. The purpose of this study was to employ radiostereometric analysis (RSA) to compare implant migration in a randomized controlled trial of this implant design with or without screw fixation over two years. Method: Fifty-one patients were randomized to receive a BioFoam total knee replacement (Wright Medical) with or without screw fixaiton. During surgery, eight tantalum markers, one millimetre in diameter, were inserted into the proximal tibia. RSA radiographs were taken postoperatively and at six weeks and three, six, 12 and 24 months following surgery using dual xray heads and an RSA calibration box. Health status and functional outcome measures were recorded to quantify functional status of subjects before surgery and at each follow-up interval. Results: The migration results at two years, calculated as maximum total point motion (MTPM), were 1.40±1.09 mm for with screw fixation and 1.28±0.84 mm without screw fixation (p value =0.821). The clinical precision of the MTPM metric is 0.33 mm, calculated as the standard deviation of measurements made from double exams of all patients. Conclusion: The migration results at two years indicate that the addition of screws does not significantly impact implant fixation and both designs are considered to display patterns of stable fixation. Although higher than the migration seen with cemented tibial components, the amount of migration is comparable to other uncemented designs. 43: Biomechanical and Neuromuscular Changes after Total Knee Arthroplasty are SexSpecific Janie L Astephen Wilson, NS; Cheryl L Hubley-Kozey, NS; Michael J Dunbar, NS Purpose: Females with moderate knee osteoarthritis (OA) walk with different movement and loading patterns than their male counterparts (McKean et al., 2007). Despite the recent emergence of gender-specific prostheses, there has been little research into the differences in the post-TKA response of the locomotor and neuromuscular systems between sexes. The objective of this study was to examine to the sex-associated differences in the patterns of knee kinematics, knee kinetics and neuromuscular control of knee muscles before and after TKA surgery. Method: Sixty-four (36 female, 28 male) individuals with end-stage knee OA underwent gait and electromyography (EMG) testing within a week prior to TKA and one year following surgery. 3D knee joint angles and net external moments were calculated over the gait cycle. EMG of 3 quadriceps, 2 gastrocnemius and 2 hamstrings muscles was recorded. Principal Component Analysis (PCA) was used to extract major patterns of the knee angles, moments and muscle groups. Three-factor ANOVA was used to test for differences in these patterns between sexes, visits (pre and post) and muscle (p < 0.10). Results: Post-TKA, females had a more constant knee adduction moment pattern during stance than males (PC2, p = 0.06). A sex by visit interaction in the knee flexion moment (p = 0.06) indicated that females shifted to a later peak extension moment in late stance and males to an earlier peak after TKA. The overall magnitude of knee adduction angles during gait reduced post-TKA for both groups (PC1, p = 0.05), but the effect was greater in females. The rotation angle in late stance became more internally rotated in females and more externally rotated in males post-TKA (PC3, p = 0.02). Female overall gastrocnemius EMG magnitudes became higher post-TKA, male magnitudes became lower (PC1, p = 0.036). Females also had later peak gastrocnemius activity in stance than males (PC2, p = 0.01). Females had higher overall magnitudes of quadriceps activity in stance (PC1, p = 0.013) and more continued activation of the quadriceps muscles during stance than males (PC3, p = 0.05). This continued activation of the quadriceps became more pronounced in females post-TKA and less so for males (p = 0.05). Conclusion: While patterns of knee and muscle function during gait have been shown to move toward asymptomatic patterns post-TKA (Hatfield et al., 2011; Hubley-Kozey et al., 2010), these results suggest that pattern changes are sex-specific, with male patterns seeming to move closer to more functional, asymptomatic patterns than females. This has implications for sex-specific surgical decision-making, implant design and post-TKA rehabilitation efforts. 44: Pre-Total Knee Arthroplasty Gait Analysis Predicts Post-Operative Changes in Function and Joint Loading Michael J Dunbar, NS; Gillian Hatfield Murdock, NS; Cheryl Hubley-Kozey, NS Purpose: The demand for total knee arthroplasty (TKA) surgery is increasing dramatically, but it is expected that the present human resources will be unable to keep up with the demand in the near future. Hence we need to develop objective models to determine who will benefit most from TKA in order to effectively manage waitlists. This study determined if changes in pain, function and joint loading could be predicted using pre-TKA biomechanics and muscle activation patterns during walking. Method: 57 participants with severe medial knee OA were tested within one week prior to TKA and approximately one year later. Participants completed the WOMAC questionnaire at each testing session (subjective measures of pain and function). Three-dimensional knee angles and moments and electromyograms from seven lower extremity muscles were recorded during gait. Gait data were analyzed using Principal Component Analysis (PCA). Self-selected gait speed and the overall knee adduction moment magnitude (PC1) were used as objective measures of function and medial compartment loading, respectively. Regression analysis determined what pre-TKA gait measures predicted the change in post-TKA subjective and objective outcome measures. Results: A phase shift in early stance activity (PC3) for the vastus medialis waveform explained 12.0% (p>0.05) and 13.7% (p<0.05) of the variance in the change post-TKA in WOMAC pain and function scores, respectively. Participants not displaying the phase shift had greater improvements in self-reported pain and function. Prolonged stance phase activity (PC2) for the lateral hamstrings explained 23.6% of the variance in the change in gait velocity (p<0.001). Participants with prolonged hamstrings activity pre-TKA had greater improvements in gait speed post-TKA. The pre-TKA score for the overall magnitude of the medial compartment load (PC1 for the knee adduction moment) was the best predictor for the change in this variable post-TKA. 62.7% of the variance was explained by the pre-TKA PC1 score (p<0.001), with an additional 4.8% of the variance being explained by the overall amplitude of activity (PC1) for rectus femoris (p<0.05). Higher pre-TKA knee adduction moment magnitude and rectus femoris activation were associated with greater post-TKA decreases in the knee adduction moment overall magnitude. Conclusion: While pre-TKA biomechanics and muscle activation patterns were poor predictors of changes in self-reported outcome measures, they did predict large proportions of variance in objective measures of function and loading. More altered muscle activation patterns and higher medial compartment loading pre-TKA, indicative of poorer pre-TKA gait patterns, were associated with greater improvements in gait speed and greater decreases in medial compartment loading. These findings have implications for managing TKA waitlists and illustrate the difference between subjective and objective outcomes. 45: The Association of Bone Microarchitecture with Total Knee Implant Stability Jen Hurry, NS; Allan Hennigar, NS; Elise Laende, NS; Michael J Dunbar, NS Purpose: Currently, orthopaedic surgeons have no method to detect or monitor arthroplasty component loosening, or predict which implants will fail. Radiostereometric Analysis (RSA) has proven sensitivity in determining relative movement between implants and underlying bone with high precision. The purpose of this pilot study is to determine if there is an association between bone mineral density (BMD) and bone microarchitecture in the proximal tibia and implant migration as measured with RSA. Method: Ten patients were followed prospectively for 1-2 years with RSA and with Dual-enery X-ray Absorptiometry (DXA) BMD scans using a GE Lunar Prodigy fan-beam densitometer. The BMD of five regions of interest in the proximal tibia were measured preoperatively, and at 1 and 2 years postoperatively. RSA exams were taken immediately postoperatively and at 1 and 2 years, with the same radiographs used for microarchitecture analysis. X-rays in these exams were captured with high-resolution Canon digital detectors (CXDI-55). Linear regression analysis was used to examine associations between BMD, microarchitecture and implant migration. Results: BMD change over time in the medial compartment has a moderately negative association with proximal translation (r squared = -0.57) and a positive association with maximum total point motion (r squared = 0.78). When adding a microarchitecture parameter from different regions of the periprosthetic tibia to the change in BMD, the amount of variation in proximal translation that is explained rises dramatically (r squared = 0.81 to 0.99). In one region of interest the microarchitecture parameter alone showed a significant relationship with internal rotation of the implant (r squared = 0.8) while no correlation with BMD was found. All p values were less than 0.05. Conclusion: Our results show that incorporating bone microarchitecture parameters in the quantitative analysis of high-resolution radiographs explains more of the variation in implant motion than can be explained when using BMD change alone. This pilot study reveals the potential of measures of bone microarchitecture for enhancing BMD assessment and as a potential surrogate indicator for implant stability. 46: The Effect of Total Knee Arthroplasty on Hip and Ankle Joint Mechanics Janie L Astephen Wilson, NS; Kathryn Young, NS; Cheryl L Hubley-Kozey, NS; Michael J Dunbar, NS Purpose: Abnormal knee function as a result of severe osteoarthritis has been well characterized. After total knee arthroplasty (TKA) surgery, comparison of knee mechanics to the pre-operative state is often used to assess surgical success. Less well acknowledged are the compensatory changes in hip and ankle joint mechanics that accompany severe knee osteoarthritis (Astephen et al, 2008), and post-TKA functional assessments rarely consider the surgery’s effect on the mechanics of these joints. The purpose of this study was to characterize the changes in joint angle patterns at the hip and ankle after TKA surgery. Method: Three-dimensional lower extremity kinematics were captured during gait for 60 asymptomatic subjects and 64 patients scheduled to receive a TKA surgery. Sagittal plane hip and ankle angles were represented as waveform patterns over the gait cycle. Principal component analysis (PCA) was applied to each angle (hip and ankle separately) to extract the major modes of variability in the data (Deluzio and Astephen, 2007). Paired t-tests were used to compare post-TKA angle patterns to the pre-TKA state and ANOVA was used to compare both to asymptomatics. Results: The first 3 principal components for hip and ankle sagittal plane flexion angles explained 92% and 87% of the variability cumulatively, respectively. The overall magnitude of hip flexion during gait (PC1) was lower than asymptomatic pre-TKA and remained lower postTKA, (P=0.037), indicating that hip flexion magnitude was not restored postoperatively. The relative difference (i.e. range) between late stance hip extension and swing phase flexion (PC2) increased from pre-TKA to post-TKA (P=0.001), yet still remained lower than asymptomatic values post-TKA (P<0.001). PC2 of ankle flexion captured the plantar/dorsiflexion range of motion throughout gait. There were no changes in PC2 from pre to post-TKA, and patients exhibited less angular range compared to the asymptomatic group (P<0.001). PC3 characterized later peak plantar and peak dorsiflexion angles in the gait cycle, and there were significant differences between pre and post-TKA (P=0.006), but no difference from asymptomatic post operatively (P=0.34). Conclusion: This study showed some improvements in sagittal plane hip and ankle angle patterns one year after-TKA surgery. However, some compensatory changes in hip and ankle mechanics that were associated with severe OA pre-TKA were maintained post-TKA. This suggests that while TKA surgery improves joint function in the lower extremity, some abnormal patterns persist that may be indicative of an unfavourable mechanical environment. Post-TKA outcome should therefore objectively assess entire lower extremity function, and implant/surgical design should aim to optimize entire lower extremity function. 47: A Murine Model of Early Onset Scoliosis Michael B Sullivan, QC; Ali Esmaeel, QC; Marco Kneifel, BC; Jean Ouellet, QC; Janet E Henderson, QC; Neil Saran, QC Purpose: Scoliosis can be infantile or juvenile in onset; however, it is more frequently identified in adolescent children, particularly girls as they enter puberty. Untreated scoliosis progresses with age and there are currently no effective nonoperative therapies to prevent this progression. Furthermore, current animal models are surgically induced and tend to use large animals: a characteristic that would preclude pre-clinical pharmaceutical therapeutic research. We have noticed that FGFR3-/- mice, in addition to severe kyphosis and other skeletal abnormalities, develop progressive scoliosis until end of life and may be a viable model of scoliosis. Method: Forty-seven FGFR3-/- and forty-four wildtype mice of a C3H background were radiographed between one and nine times with posterior-anterior and lateral views to measure kyphotic and scoliotic Cobb angles. Mice were euthanized at ages ranging from 4 to 25 weeks and processed for histology and high resolution micro-computed tomography (micro-CT) to compare parameters such as vertebral and inter-vertebral disc (IVD) morphology, micro architecture, vertebral rotation, and cellular activity. Knockout mice were paired with an age and gender matched wildtype counterpart for micro-CT and histological analysis to ensure that scoliotic apical vertebrae were compared to the equivalent wildtype vertebrae. Results: FGFR3-/- mice developed scoliosis by 8 weeks (p<0.05) and scoliosis progressed until the end of study, reaching a maximum of 40.9o±18.3 compared to wild-type counterpart of 5.1o±4.2. The present model has 98% incidence (≥10o) by skeletal maturity, though location and severity are varied. Micro-CT analysis of knockout vertebral body micro architecture revealed decreased Bone Volume Fraction (BV/TV) of the convex side and decreased IVD thickness on the concave side of the curve. Vertebral body height was greater on both concave and convex sides, with convex being comparatively greater. Histological analysis of bone mineralization and cartilage support micro-CT data, and indicates concave IVD compression and nucleus pulposus translation towards the convex side. Conclusion: FGFR3-/- mice developed a high incidence of progressive scoliosis prior to skeletal maturity. Results reveal that a characteristic scoliosis develops with respect to vertebral wedging, intervertebral disc wedging and osteopenia. Because the proposed model features spontaneously occurring scoliosis, we see it as more useful model than ones that are surgically induced. FGFR3-/- mice are an improved animal model that are inexpensive, easily available, non-invasive, and closely reproduce the disease and should be used for future development of non-surgical treatments of scoliosis. 48: Correlations between Quantitative MRI and Mechanical Parameters of Human Intervertebral Discs with Different Grades of Degeneration John Antoniou, QC; Laura M Epure, QC; Arthur Michalek, VT; James C Iatridis, NY; Fackson Mwale, QC Purpose: The dramatic changes in morphology, composition, and structure that occur in the intervertebral disc (IVD) with aging and degeneration are accompanied by specific changes in material properties. Evaluation of these changes hinges on the ability to objectively and noninvasively assess disc matrix composition and integrity. Different studies on bovine IVDs have correlated disc matrix composition and integrity to the quantitative magnetic resonance imaging (qMRI) indicating that MRI signal can be used to predict structural changes in discs with degeneration. The aim of the present study was to determine correlation between qMRI parameters and material properties in human discs with different grades of degeneration in order to evaluate the predictability of mechanical integrity of the disc from the MRI signal. Method: Fifty human discs (grade 2, 3, and 4 of degeneration) from 10 lumbar spines were obtained through organ donations via Héma-Québec within 24 hours after death. The qMRI examinations were carried out in a 1.5T whole-body Siemens' Avanto system. All discs were graded from T2-weighted images according to the classification system described by Pfirmann. Numerical analysis of qMRI was performed using a custom code written in MATLAB (Mathworks, Natick, MA). Confined compression tests were performed on 5 mm diameter cylindrical plugs of tissue using a custom built axial testing machine. Material parameters (aggregate modulus HA and permeability k) were obtained from a linear biphasic fit. Dynamic shear testing was carried out using a rheometer (TA Insturments). Steady state dynamic shear modulus and phase angle were calculated at each point of the frequency and strain sweeps and fitted with exponential functions. The correlations between qMRI and mechanical parameters were investigated using Pearson test performed on GraphPad Prism Software (La Jolla, CA, USA). Results: When the tissues were analyzed separately, for the NP tissue significant correlations were found between T2 and shear modulus |G*| (r = - 0.465, p = 0.022), and between diffusion ADC and αδ (r = 0.4, p = 0.047). For the AF tissue significant correlation were found between T1 and phase angle αδ (r = 0.372, p = 0.047) and between T1 and permeability k (r = -0.468, p =0.043). No correlations were found between MTR and any mechanical parameters for both AF and NP tissues. Conclusion: The results of the present study are consistent with our previous studies in bovine model and indicate sensitivity to distinct changes at varying levels of degeneration. In the AF, permeability and phase angle were predicted by T1 while in the NP tissue, T2 was a stronger determinant of the tissue integrity (reflected by shear modulus). These results prove that it is possible to develop correlations and multiple linear regressions in human IVDs which are essential for developing quantitative MRI as diagnostic tool for IVD degeneration. 49: Effect of Neonatal mice exposure to Diethystilbesterol on Lumbar and Femoral Bone and Articular Cartilage in Male and Female Adult Progeny Subjected to Swimming Exercise Rahul Gawri, QC; Sora AlRowas, QC; Rami Haddad, QC; Lorraine Chalifour, QC; John Antoniou, QC; Fackson Mwale, QC Purpose: Neonatal exposure to Diethylstilbestrol (DES) has been shown to adversely affect a number of estrogen sensitive tissues, including bone.Effects of in utero DES exposure have also been shown to affect the third generation. Environmental exposure to estrogens was shown to be higher than anticipated.The aim of this study is to determine the effect of in utero exposure to DES on bone and articular cartilage of adult mice. Method: Pregnant C57/bl mice were injected with either vehicle (peanut oil) or one of three doses of DES (0.1, 1.0, and 10.0 µg/kg/day) at 11-14 days of gestation.A minimum of 3 dames was set for each group. Pups were then allowed to grow to adulthood without further intervention until three months of age.At this point mice were randomized into two groups; one with a once daily swimming regimen which started as five min. and was escalated to a maximum of 1 h. The second group were left to their normal activity level and considered sedentary. All animals were sacrificed at exactly 4 months of age. The knee joint and lumbar spine was dissected from 3 animals per group. The lumbar and femoral regions of each intact mouse were scanned for Bone Densitometry. Bone mineral density (BMD), bone mineral content (BMC), bone area (BA) and trabecular bone area (TBA) were all measured for lumbar and femoral bones.Histological evaluation was also done on the dissected knee joints. Results: The lumbar BMCs showed significance at 10.0 µg/kg/day for the female swim group. The male swim group showed an opposing trend with a dose related decrease in BMC which became significant at 10.0 µg/kg/day. The femoral BMC interestingly showed opposing trends for males and females. The swim female femoral BMC showed a significant increase at 10.0 µg/kg/day. The swim male femoral BMC showed a markedly significant decrease at that same dose. The femoral BMD was slightly more affected than the lumbar BMD. There was a general trend for decreased femoral BMD which only became significant in the male swim group at 10.0 µg/kg/day. The female sedentary articular cartilage showed decreased staining of the articular cartilage at all three doses of DES compared to control. In female swim group, articular cartilage showed decreased staining at 0.1 and 10.0 μg/kg/day of DES. No difference was noted at 1.0 μg/kg/day of DES. The male sedentary articular cartilage showed increased staining at 0.1 μg/kg/day of DES, otherwise no difference was noted at the other doses. The male swim articular cartilage showed decreased staining was at 0.1 μg/kg/day of DES, otherwise no difference was noted. Conclusion: Bone and articular cartilage are known to be estrogen-sensitive tissues.Our study shows that DES in utero exposure can have effect on bone and articular cartilage. The mechanisms of the effects of DES are however not well understood and further studies are necessary.This study might shed light on the possible increased risk of disc degeneration in the sons and daughters of mothers exposed during gestation,as well as their children. 50: Effects Of Photodynamic Therapy In Combination With Radiation Therapy On Healthy And Metastatically-Involved Vertebrae Victor Lo, ON; Margarete K Akens, ON; Sara Moore, ON; Albert JM Yee, ON; Brian C Wilson, ON; Cari M Whyne, ON Purpose: The cornerstone of spinal metastasis treatment includes radiation therapy (RT), bisphosphonates (BPs) and surgery. RT is limited by increased risk of fracture post-irradiation and dose limits, BPs reduce bone resorption but may not destroy tumour tissue and surgery is associated with a high morbidity. Photodynamic therapy (PDT) has been shown to ablate tumour cells and enhance bone formation in an athymic rat model of metastatic breast cancer, demonstrating potential as a treatment for spinal metastasis. When combined with previous BP treatment, bone formation was further enhanced by PDT. The objective of this study was to determine the effects of PDT in combination with previous RT on both healthy and metastatically-involved vertebrae. Method: Sixty-four athymic rats underwent RT (4Gy) at day 7, with 23 rats inoculated with MT1 human breast cancer cells at day 0 via intracardiac injection. Rats undergoing PDT treatment received an intravenous injection of BPD-MA photosensitizer on day 14. After a 15-minute drug-light interval, 75J of light energy was delivered from a 690nm laser adjacent to the L2 vertebra. Rats were sacrificed on day 21 or 56 (healthy only) and structural properties of all L2 vertebrae were quantified via analysis of µCT images. Mechanical properties were evaluated in half of the specimens by loading the L2 vertebral body to failure in axial compression. The remaining vertebrae were analyzed for morphology, osteoid formation, osteoclast activity, and tumour burden using histological methods. Results: Significant improvements in trabecular structure were found in combined PDT+RT treated healthy vertebrae compared to RT alone at both short (6% increase in trabecular thickness) and longer (22% increase in bone volume fraction and 19% decrease in trabecular separation) time-points. Mechanically, there were no differences in ultimate force and stiffness. In the metastatic vertebrae, the applied RT dose surprisingly ablated all tumour cells in the treatment region. Minimal stereological differences and no differences in mechanical properties were detected between PDT+RT and RT alone treated metastatically-involved vertebrae. Results were compared to previous data examining untreated and PDT-treated healthy and metastatic vertebrae. Combined PDT+RT treatment on healthy vertebrae yielded increases in trabecular structure compared to untreated vertebrae, while RT alone did not yield any differences. Both PDT+RT and RT-only treatment greatly improved structural and mechanical properties of metastatically involved vertebrae compared to untreated or PDT-only treatment, due to the early destruction of tumour in RT-treated groups. Increased amounts of woven bone and osteoid volume were found in PDT-treated vertebrae. Conclusion: The ability of PDT to ablate tumour tissue, enhance bone formation, and lack of detrimental effects on vertebral structure when combined with RT motivates the use of PDT as a minimally-invasive technique for the treatment of spinal metastasis. 51: Evaluation of Instrumentation Techniques for a Unilateral Facet Fracture Using a Validated Soft Tissue Injury Model Stewart D McLachlin, ON; Melissa Nadeau, ON; Stewart I Bailey, ON; Kevin R Gurr, ON; Cynthia E Dunning, ON; Christopher S Bailey, ON Purpose: Traumatic flexion-distraction injuries of the cervical spine result in a spectrum of injury and instability. Anterior, posterior or combined fixation has produced successful outcomes when generalized to the entire injury spectrum or catastrophic injury models. However, there is a lack of literature comparing these instrumentation techniques for specific injury patterns; in this case, a unilateral facet perch (UFP) with an associated facet fracture. The addition of the facet fracture is especially important in light of recent clinical data identifying an increased failure rate of the anterior approach in the setting of a facet fracture. Therefore, the purpose of this study was to use a standardized UFP soft tissue injury model to evaluate the effects of the addition of a facet fracture, as well as to compare the improved stability following three surgical fixation techniques. Method: Five fresh-frozen spinal segments (C4-5) were cleaned of musculature and mounted in a spinal loading simulator. Stability testing in flexion-extension, lateral bending, and axial rotation was performed following each stage of the testing protocol. The magnitude of C4-5 range of motion (ROM) was measured using an Optotrak Certus™ tracking system. Specimens were tested first with the UFP soft tissue injury (both capsules, ¾ of the annulus, and ½ of the ligamentum flavum), followed by a 50% unilateral facet fracture, and then a complete unilateral facet fracture. Three proposed instrumentation techniques were then sequentially tested on each injured specimen. Posterior screw and rod instrumentation was tested first, followed by anterior plating instrumentation, and finally combined posterior-anterior instrumentation. ROM of the facet fracture injuries were compared relative to the initial injured state, while instrumentation techniques were evaluated based on their ability to reduce ROM relative to the final injured state. Statistical analysis used one-way repeated measures ANOVAs and post-hoc SNK tests (α=0.05). Results: Both facet fracture injuries did not cause an increase in ROM beyond the original UFP soft tissue injury (p>0.05). All three fixation techniques successfully reduced ROM from the final injured state (p<0.001), but both the posterior and combined approaches allowed less ROM than the anterior approach in axial rotation and lateral bend (p<0.001). Conclusion: In this study, the addition of the complete unilateral facet fracture to the soft tissue injury present in a UFP did not further destabilize the spine as measured by the ranges of motion in the anatomic planes. However, the instrumentation approaches used to stabilize the spine showed that anterior instrumentation was inferior to both posterior and combined approaches in the setting of the unilateral facet fracture. It is suspected that the further soft tissue destabilization of the spine required for the anterior approach is not reestablished with instrumentation in the setting of a facet fracture. 52: Structural Evaluation of Whole Vertebrae through Micro Finite Element Modeling and Histological Damage Assessment Ryan Herblum, ON; Cari M Whyne, ON Purpose: Current advancements in computational power and micro-imaging techniques allow the creation of finite element (FE) models on a micro-structural level that can elucidate the mechanical integrity of individual trabeculae. However histological validation of such µFE models has been limited to trabecular cores or in bones with removed endcaps, rather than whole bone structures. The objective of this study was to evaluate the micro level structural integrity of healthy vertebrae through µFE modeling validated with histological damage assessment. Method: A combination of sequential labeling with loaded-unloaded µCT imaging was performed to generate and validate µFE models of three wistar rat spinal motion segments. Calcein green was used to label pre-existing micro-damage. Specimens were µCT imaged unloaded and under a 100N axial compressive load. Following testing, fucshin staining was conducted on the whole vertebrae to identify mechanically induced microdamage. µFE models of the central vertebrae were generated from the unloaded µCT images. Boundary conditions were applied based on deformable registration with the loaded µCT images. µCT images of the histology sections were also acquired to locate the corresponding regions within the µFE model. Damaged (n=20) and undamaged (n=20) regions were identified from the basic fuchsin histology and compared to corresponding stress and strain values from equivalent locations in the µFE models. Independent and paired t-tests were performed to compare damaged to undamaged regions in the whole vertebrae and locally around single trabeculae. Results: µFE models of the whole vertebrae were successfully generated with accurate integration of the histologically defined regions. The whole bone sequential labelling process showed mechanically induced damage within the vertebral trabecular networks. The majority of damage was observed near the endplates. In comparing histologically damaged to undamaged regions in the µFE models, significantly higher von-mises stress (max: 263MPa vs172MPa; avg: 173MPa vs. 115MPa) and principle strains (max: 1.4 % vs. 0.9%; avg: 0.9% vs. 0.6%) were found in the damaged regions. Similarly, in paired comparisons of adjacent regions von mises stresses and principle strains were significantly elevated in the damaged regions. Conclusion: This study presents a robust method for validating µFE of whole vertebrae. The adapted staining technique successfully labelled mechanically induced microdamage in the whole intact vertebrae allowing the evaluation of the effects of ‘physiological loading’ through the intervertebral discs. The use of image registration to determine boundary conditions reduced the computational demands of the modeling and registering the multimodal images enabled the accurate comparison of the 2D histology to the 3D µFE model results. 53: The Effect of Soft Tissue Restraints Following Type II Odontoid Fractures in the Elderly – A Biomechanical Study C Maxwell J McCabe, ON; Stewart D McLachlin, ON; Stewart I Bailey, ON; Kevin R Gurr, ON; Chris S Bailey, ON; Cynthia E Dunning, ON Purpose: Fractures of the odontoid process are the most common cervical spine injuries in the elderly, and of these, type II fractures are the most frequent. In this patient population, these fractures commonly occur with low-energy injury mechanisms, including falls from a standing height. With this mechanism, some restraints to displacement, such as those provided by the ligamentous structures, remain in the setting of a type II odontoid fracture in an elderly patient. The stabilizing role of these soft tissue restraints in this context has not been explored in the literature. The purpose of this study was to determine the restraint to pathological motion provided by the passive soft tissues stabilizers surrounding the C1-C2 joint in the setting of a simulated type II odontoid fracture in cadavers older than 75 years of age. Method: Ten cadaveric CO-C2 spinal segments were studied. Specimens were tested under simulated axial rotation with an applied moment of ±1 Nm and with the direct application of 10 N anteriorly-directed force to the body of C2 to induce sagittal translation. Optical motion data was initially collected for the intact state, and after a simulated dens fracture. The specimens were then divided into two groups, where one group underwent unilateral then bilateral C1-C2 facet capsular injuries followed by anterior longitudinal ligament injuries. The second group underwent the anterior longitudinal ligament injure prior to the same capsular injuries. Changes in axial range of motion (ROM) and C1-C2 translation were recorded and were analyzed using two-way repeated measures ANOVAs and post-hoc Student-Newman-Keuls tests (α=0.05). Results: In axial rotation, there was an increase in ROM by approximately 13% with the fracture of the dens compared to the intact state (p<0.05). An increase was also present for each subsequent soft-tissue injury state compared to the previous (p<0.05); however, there was no difference found between the two soft tissue sectioning protocols. For sagittal translation testing, it was found that the odontoid fracture alone showed an increase of 3 mm of C1-C2 translation compared to intact (p<0.05). Further soft tissue injuries did not show an increase until the complete injury state. Conclusion: The provocative sagittal translation loading demonstrated the previously recognized role of the dens as a primary stabilizer. There was essentially no translation in the intact state and the dens fracture led to an increase in translation of approximately 3 mm. However, no further increase was seen with sequential ligament sectioning until all tested ligaments were sectioned. This illustrates that the ligaments do not provide a cumulative influence, but rather an “all or nothing” effect. This helps to support the hypothesis that the surrounding soft tissues will provide an important stabilizing influence in an odontoid fracture produced by a low energy mechanism in an elderly patient. 54: The Therapeutic Potential of Link-N in the Treatment of Human Intervertebral Disc Degeneration Rahul Gawri, QC; Fackson Mwale, QC; Jean Ouellet, QC; Thomas Steffen, QC; Peter Roughley, QC; Lisbet Haglund, QC; John Antoniou, QC Purpose: Intervertebral disc degeneration is the single most common implicated cause of back pain. Presently there is no medical treatment and surgery is the only offered option.Link-N peptide has been speculated to play a role in matrix homeostasis by promoting new matrix synthesis.We evaluated its regenerative potential in intervertebral discs by means of a whole organ culture model developed by us. Method: Lumbar IVDs, from 7 individuals were obtained through organ donations via Transplant Quebec within 6 hours after death. Cellular studies were performed on cells isolated from nucleus pulposus (NP) and inner annulus fibrosus (iAF) regions of the discs. Cells were beaded in 1.2% alginate and exposed in culture to Link-N for 48 hours in concentrations ranging from (10-10000) ng/ml for dose response.The discs were prepared for organ culture and cultured with no external load applied. Link-N was conjugated with 5-TAMRA dye and distribution of Link-N in the medium and within the disc after injection was studied to see whether Link-N is retained in the disc due to interaction with the matrix or diffuses out. Discs from adjacent levels were injected in their NP region with 50µCi of 35SO4 along with 0.1mg or 1mg of Link-N in 100µl of medium per disc and harvested after 48 hours.Sustained regenerative effect of Link-N was evaluated by injecting the disc with Link-N and injecting 35SO4 one week later.Response to Link-N was evaluated by monitoring 35SO4 incorporation. Results: Human lumbar disc cells from NP and iAF regions beaded in alginate were exposed to Link-N peptide for 48 hours and proteoglycan synthesis was observed to increase in a dose dependent manner with the maximal response at 1000ng/ml of Link-N. To determine if Link-N freely diffuses throughout the disc and equilibrates with surrounding medium, 1mg Link-N peptide conjugated with 5-TAMRA dye was injected. TAMRA-Link-N was detectable in the medium at 24 hours and reached equilibrium after 48 hours. The fluorescent peptide was found to localize in NP and NP/iAF junction but its further diffusion in the disc was restricted by collagen fibers.Loss of Link-N appears to occur by diffusion through the endplates. Discs injected with Link-N showed increased proteoglycan synthesis in the NP and iAF compared to adjacent level control discs. To evaluate the duration of the effect, discs were injected with 35SO4 one week after the injection of Link-N and continued to show an increase in proteoglycan synthesis thus suggesting a sustained effect of Link-N in increasing proteoglycan synthesis. Conclusion: In this work we show that Link-N can promote proteoglycan synthesis 3D cultures of human disc cells. Link-N has the potential to be a candidate for biologically induced disc repair as increased proteoglycan synthesis was observed in intact human discs.In the future, Link-N may provide an alternative to surgery for early stage disc degeneration. Link-N has a significant cost advantage over other bioactive proteins such as BMP7, TGF-B and GDF5. Link-N is over 100 times less expensive than recombinant growth factors that have a similar repair response. 55: A Prospective Randomized Multicentre Evaluation of a “New” MIS Approach to THA: Stem Subsidence an Issue? Nelson V Greidanus, BC; Samir Chihab, BC; Donald S Garbuz, BC; Bas A Masri, BC; Michael Tanzer, QC; Allan E Gross, ON; Clive P Duncan, BC Purpose: To examine the potential superiority of a “new” intermuscular surgical approach to limited incision total hip replacement. Method: After a learning curve which included a hands-on course and a combined number of 95 cases (minimum 10 per surgeon), five subspecialized hip surgeons, at three academic centres, participated in the study of a “new” anterolateral MIS approach to THR. It was a multicentre, prospective, randomized trial, comparing it to the “standard” limited incision approaches already in use (direct lateral or posterolateral). HRQoL outcomes were assessed at baseline and intervals out to 24 months. Detailed, blinded, radiographic measurements were performed on 134 cases (representing all three sites) including cup alignment in two planes, stem alignment, subsidence, loosening and fractures. Parametric and nonparametric analyses were performed. Results: A total of 156 patients were recruited and the same implant system used in every case. There was no difference between groups at baseline (pre-op age, gender, BMI, comorbidity, WOMAC). Similarly, interval HRQoL outcomes out to 24 months were not different (p>.05). Cup and stem alignment were satisfactory with no difference between the groups at all sites(p>.05). However stem subsidence was 4.6mm for G3 approach and 4.1mm in the alternate group with significant differences observed on inter-site analyses for subsidence (p=.004). An increased rate of trochanteric fractures was observed and two patients in the “new group” have already required revision. Conclusion: This study failed to demonstrate superiority with the “new” anterolateral (socalled G3) approach. Detailed radiographic analyses demonstrates inter-site differences in painful stem subsidence and fracture. Likely this is related to the greater technical challenge of exposure with this approach in some patients, leading to the risk of undersizing the stem in those cases. The authors have returned to the standard surgical approaches in use before the trial. 56: A Single-Centre Preliminary Experience of the Anterior Approach for Total Hip Arthroplasty Paul E Beaulé, ON; Paul R Kim, ON; Kyle A Kemp, ON Purpose: The anterior approach is the only purely internervous and intermuscular approach to the hip. Despite these advantages, its use in Canada remains limited. The purpose of this study is to present the short-term results and complications with this approach. Method: Over a 40-month period, 200 anterior approach THAs were performed at our centre by two surgeons in 184 patients: 121 males & 63 females; mean age 63.61 yrs (33 to 92); mean BMI 28.33 (18.6-44.6). Eight of 16 patients underwent simultaneous bilateral THA. Patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) prior to surgery and at latest follow-up. Results: At follow-up of 24-60 months, WOMAC scores improved significantly (p<0.001 in all cases). Two patients deceased unrelated to surgery. Four cases of calcar fracture were managed intra-operatively using cable fixation. Two femoral canal perforations were recognized intra-operatively. Seven complications occurred within first 8 post-operative weeks: 5 infections (two of which required an irrigation & debridement); 1 DVT and 1 iliac wing fracture. In total, eight re-operations were required at a mean time of 23 months (11-40mos): 5 in large Head MOM, 1 Accolade Stem loosening and 2 deep infections requiring two-stage reimplantation. Conclusion: Based on our early results, the anterior approach is a reasonable alternative to the traditional anterolateral or posterior surgical approaches for THA. Further long-term studies and comparisons to other approaches will determine if the anterior approach will become the preferred approach for total hip arthroplasty. 57: Comparison of Outcomes and Survivorship Between Patients of Different Age Groups Following Total Hip Arthroplasty Murray C Blythe, ON; Chris Robert, ON; James L Howard, ON; Douglas Naudie, ON; James P McAuley, ON; Richard McCalden, ON; Robert B Bourne, ON; Lyndsay Somerville, ON; Steven JM MacDonald, ON Purpose: Total hip arthroplasty offers both patients and surgeons excellent and predictable clinical results in the treatment of arthritis of the hip. It is being performed with increasing frequency in younger patient populations. The purpose of this study was to evaluate and compare the survivorship (5 and 10 year) and clinical outcomes of patients of different age groups that underwent THA at our institution. Method: A retrospective review based on a prospective database was performed on 5,047 consecutive patients that underwent primary THA between January 1996 to December 2009. Patients were then divided into 3 groups based on their age: <55, 55-70 and >70 years. Clinical outcomes were assessed using the WOMAC, SF-12 and Harris Hip Score (HHS). The outcome score change was determined by subtracting the preoperative score from the most recent available postoperative score. The outcome score change was then compared between the 3 age groups. Kaplan-Meier analysis was performed on each group of patients to calculate survivorship at 5 and 10yrs with revision for any reason being the endpoint. Results: Comparing the <55, 55-70 and >70 age groups respectively, there was a statistically significantly difference in the WOMAC total change score (41 vs 38 vs 34, p<0.0001). This pattern of change was also found when the WOMAC was broken down into its subscales including pain, stiffness and function. There was also a statistically significant difference in the change in HHS favoring the younger populations (<55rys: 45.0 vs 55-70yrs: 43.6 vs >70yrs: 40.7). The Kaplan-Meier survivorship for the <55, 55-70, and >70 years age groups at 5 years was 96.6%, 96.0% and 96.2% and at 10 years was 93.0%, 94.2% and 95.9% respectively. Revision secondary to infection was a major cause for failure in the older age groups while polyethylene wear was the most common means of failure in the <55 age group. Conclusion: This study has shown that younger patients experience better clinical outcomes following THA according to the HHS, WOMAC and SF-12, and similar survivorships, when compared to older patient populations. THA is an excellent treatment for arthritis of the hip, even in younger patients. 58: Compliance with Thromboprophylaxis using an Oral Factor Xa Inhibitor (Rivaroxaban) after Total Hip and Knee Arthroplasty. Is Oral therapy better? An Examination of the Non-Adherence rate of Rivaroxaban Sebastian R Rodriguez-Elizalde, ON; John J Murnaghan, ON; Helen Razmjou, ON; Debbie Murnaghan, ON; Jeffrey Gollish, ON; Benedict A Rogers, ON; Andrew Carrothers, ON Purpose: Post-operative thrombo-prophylaxis is believed to reduce the perioperative risk for patients following total hip and knee arthroplasty. The non-adherence rate in the literature for patients completing their prescribed course of traditional thrombo-prophylaxis varies from 540%. Newer oral thrombo-prophylatic agents are now available (factor Xa inhibitors), however their patient compliance rate is unknown. This study compares the compliance rate of a prescribed oral factor Xa inhibitor, Rivaroxaban®, for the thrombo-prophylaxis of postoperative hip and knee arthroplasty patients and compares it to the established literature compliance rates of other modalities. The non-adherent patients were then subgroup analysed to examine for non-compliant patient risk factors. Method: Since January 2010, an on going prospective database for all total joint replacement surgeries has followed patients treated with thrombo-prophylaxis post-operatively. As a standard of care, a self-administered questionnaire is recorded at the six-week mark. This includes information about the medication used for thrombo-prophylaxis, the prescription administration, compliance and complications from therapy. The compliance of their prescribed fifteen-day therapy was then calculated and compared to the published literature compliance rates of other thrombo-prophylaxis agents. A sub-group analysis was then undertaken of the non-adherence (NA) group. Results: A total of 1789 patients (1045 total knees and 744 total hips) received a prescription for Rivaroxaban post-operatively. Of these, 53 (3.0%) did not complete their six-week follow up questionnaire. Another 52 (2.9%) stated they did not complete the entire course of prescribed therapy. The overall compliance rate of those given a prescription is 97.1%. If we assume all those lost to follow-up did not complete their prescribed course, the compliance drops to 94.1%, leaving a non-adherence (NA) rate of 5.9% for Rivaroxaban. The group of stated nonadherent patients were more likely to be female (71.2% vs 60.1%, p=0.03), and were trending to have a higher BMI (30.6 vs 28.9, p=0.08). Age was not a factor for either group. Four patients who were NA encountered bleeding complications, compared to 18 in the compliant group (7.5% vs 1.1% p=0.01). Conclusion: This study demonstrates that patients are more likely to complete a thromboprophylaxis regime on an oral Factor Xa inhibitor than other therapies. The stated NA rate of prescribed Rivaroxaban is 2.9%. Assuming all those lost to follow-up were non-adherent, the calculated overall NA rate would be 5.9%. This compares favourably to the non-adherence rates of injectable low molecular weight, which has multiple published series demonstrating NA of 5-40%, and most recently, a large multi-center series of 1315 patients showing a NA of 20.8%. This study demonstrates that the prescription of rivaroxaban affords a superior patient compliance compared with subcutaneous LMWH. 59: Evaluation of the use of Spinal Epimorph in Total Hip Arthroplasty: A Prospective Double-Blinded Randomized Control Trial Rajrishi Sharma, ON; Aaron Bigham, ON; Sugantha Ganapathy, ON; James P McAuley, ON; Richard McCalden, ON; Douglas Naudie, ON; Steven JM MacDonald, ON; Robert B Bourne, ON; James L Howard, ON Purpose: The primary preoperative concern for patients undergoing total hip or total knee arthroplasty is the anticipation of pain postoperatively. With increasing demand of total joint arthroplasty, focus in obtaining the most comfortable anesthetic with minimal complications is paramount. Spinal anesthesia with adjuvant intrathecal opiates have been used since the early 1980’s with no focus on whether there is a clinical benefit within the arthroplasty population. The purpose of our study was to determine in patients undergoing total hip arthroplasty whether spinal with epimorph versus spinal without epimorph resulted in better pain control and fewer complications. We hypothesized that there would be no difference in pain control and higher complication rate in patients undergoing total hip arthroplasty with intrathecal spinal epimorph. Method: We performed a prospective double-blinded randomized clinical trial with 60 patients (31 with spinal epimorph and 29 without spinal epimorph). Pain was assessed using the visual analogue pain score and narcotic usage was recorded at various time intervals. Any complications were recorded. Results: Our study found a statistically significant improvement in pain six (p=0.001) and 12 hours (p=0.003) post surgery and significant decrease in narcotic usage between 6-12 hours post operative (p=0.009). Beyond 18 hours there was no statistical difference between the two groups. There was however, a statistically significant increase in complications with spinal epimorph including need for Foley catheter (p=0.024), nausea (p=0.020), vomiting (p=0.006) and pruritis (p=0.015). Conclusion: This study confirms improved clinical pain scores with spinal epimorph only within the first 18 post-operative hours. However, increased complications have been found. Therefore, care must be taken if intrathecal epimorph is used. To decrease these complications, the use of known pre-operative analgesic modalities and intra-operative local anaesthetic mixtures may eliminate the need for intrathecal epimorph. 60: Inpatient Mortality after Primary Total Hip Arthroplasty: Analysis from the National Inpatient Sample Database Kenneth David Illingworth, IL; Youssef el Bitar, IL; Devraj Banerjee, IL; Steven L Scaife, IL; Wendy M Novicoff, IL; Khaled J Saleh, IL Purpose: As the population ages, the number of patients requiring total hip arthroplasty for end stage osteoarthritis will continue to grow. Although inpatient mortality rates following total hip arthroplasty are low, understanding factors that influence inpatient mortality rates are critical in order to maximize patient safety. The purpose of this study was to assess factors that influence inpatient mortality rates after primary total hip arthroplasty in a large national database. Our hypothesis is that increased mortality will be associated with an increased age and the presence of inpatient complications. Method: Weighted discharge data from the 2007-2008 HCUP Nationwide Inpatient Sample database were used in this study. Patients were identified based on whether they were admitted for a primary total hip arthroplasty using the International Classification of Disease and Related Health Problems (ICD-9-cm) code and grouped based on their inpatient mortality status. Mortality rates were explored using patient demographics, hospital demographics, inpatient complications, co-morbidities, elective vs. non-elective surgery and weekend admissions. Univariate analyses and an adjusted logistic regression analysis revealed a large number of relevant variables. A principal components analysis was used as a strategy to reduce the number of variables in the final logistic regression model. Results: In 2007-2008 there were 530,079 primary total hip arthroplasty discharges with an inpatient mortality rate of 0.20%. Frequency of mortality was significantly higher for increased inpatient complication rates (Pulmonary > Cardiovascular > Mechanical wound > Systemic > Infection > Gastrointestinal > Urinary), weekend/elective surgery admission, increasing age and having Medicare payer provider. Using a principal components analysis, 5 factors were identified that were significantly related to mortality. The five factors are listed with odds ratios and 95% confidence intervals and included a Demographic Factor (Age/Payer Status ((Medicare/Medicaid/Private/Other))(0.793, 0.742-0.847), a Location Factor (age/rural or urban location/median household income/location of hospital)(1.113, 1.058-1.171), an Elective Factor (elective or non-elective surgery/weekend admission)(5.42, 4.736-6.201), a Co-Morbidity Factor (Charlson Score/diabetes/obesity/sleep apnea)(0.702, 0.654-0.755), and an Inpatient Complication Factor (cardiovascular/pulmonary/ mechanical/wound/infection/systemic/ gastrointestinal /urinary)(0.168, 0.156-0.181). The odds ratios for all 5 factors were significant (p < 0.05). Conclusion: Mortality rates following total hip arthroplasty were significantly affected by multiple factors and these factors should be taken into account for any patient undergoing primary total hip arthroplasty. Most significantly, inpatient complications should be minimized at all costs as these were associated with the highest increased frequency of mortality. 61: Outcomes and Complications of Total Hip Arthroplasty in the Super-Obese: A Retrospective Analysis Raghav Rajgopal, ON; Robin Martin, ON; James L Howard, ON; Douglas Naudie, ON; James P McAuley, ON; Richard McCalden, ON; Steven JM MacDonald, ON; Robert B Bourne, ON Purpose: Obesity is a global epidemic and leads to a multitude of adverse health outcomes including osteoarthritis. Obese patients tend to require joint arthroplasty at earlier ages compared to normal weight patients. Many studies looking at perioperative arthroplasty complications and outcomes in obese patients demonstrate no significant differences compared to normal weight patients. However, there is limited data examining outcomes specifically in super-obese (BMI > 50) patients, which is an increasingly prevalent population. The purpose of this study was to examine complication rates in super-obese patients undergoing total hip arthroplasty. Method: Forty super-obese patients who underwent total hip arthroplasty were identified in our institution from 1998-2009. There were 33 women and 7 men with a mean age of 53. This group was matched to patients of normal weight (BMI 20.1-24.9) and class I obesity (BMI 30.134.9). Patients were matched for age, gender, length of follow-up, and pre-operative diagnosis. Groups were then examined for differences with respect to implant, transfusion rate, surgical time, length of hospital stay, satisfaction (WOMAC, HHS, SF-12), complications, readmission rate, and re-operation rate. Differences were determined using ANOVA, Tukey test, and Fisher exact test (p < 0.05). Results: A retrospective analysis was performed examining complications and patient satisfaction. We found that super-obese patients demonstrate an increased length of stay in hospital (p < 0.05), nine-fold increase in major complication rate (p < 0.001), six-fold increase in re-admission rate (p < 0.05), and six-fold increase in re-operation rate (p < 0.05) compared to normal weight and class I obesity groups. Although super-obese patients demonstrated reduced pre- and post-operative satisfaction scores, there was no significant difference in improvement, or change score, with respect to SF-12, HHS, or WOMAC. Conclusion: Super-obese patients obtain similar satisfaction outcomes as class I obesity and normal weight patients with respect to change scores. However, they experience a significant increase in length of hospital stay, major complication rate, re-admission rate and re-operation rate. 62: PATH? Total Hip Arthroplasty – Improved Early Mobility and its Economic Impact in a Canadian Centre Cai Wadden, ON; Alan Forster, ON; Jodi Pachal, ON; Wade T Gofton, ON Purpose: The purpose of this economic analysis was to compare the direct hospital cost of a traditional Total Hip Arthroplasty (THA) to a THA performed using a Percutaneously Assisted Total Hip (PATH). Method: Fifty with fifty matched conventional THA patients performed by a single surgeon at a single hospital. Patients undergoing bilateral procedures or having severe contralateral arthritis affecting mobilization were excluded. Results: The two patient cohorts were found to be similar with respect to average age, gender, ASA classification and body mass-index. Pre-hospital costs were found to be equivalent. Early operative times were longer f min – 5 min for intra-operative ximplant prices were higher due to modularity options, the use of a disposable reaming cannula and fixed hospital contracts. However significant savings are realized based on reduced transfusion rates (4% versus 26%), acute care length of stay, 2.96 versus 4.26 days and both the necessity for rehabilitation (12% versus 36%) and duration when required (9.5 versus 12.8 days). There was no significant difference in complications or readmission rates between groups. No obvious difference in Home care utilization was identified. Conclusion: Despite a slight increase in implant costs and disposables the PA preserving technique allowed for earlier mobilization and reduced length of acute care stay. The percentage of patients requiring a rehabilitation stay was also significantly reduced. It is possible to extrapolate that with a shorter LOS, various daily costs for medications, other administered products and service related costs are not incurred that otherwise would be with patient length of stay, both in the acute care and rehab setting, and hospital costs. 63: Simultaneous versus Staged Bilateral Total Knee Arthroplasty: A Meta-analysis Evaluating Mortality, Peri-operative Complications and Revision Surgery Rates Nasir Hussain, ON; Ammar Bookwala, ON; Teresa Chien, ON; Nicole Simunovic, ON; Vijay Shetty, IN; Mohit Bhandari, ON Purpose: An important debate in many orthopaedic practices is the choice of performing simultaneous or staged bilateral total knee arthroplasty. The objective of this meta-analysis is to determine the effect of simultaneous bilateral and staged bilateral total knee arthroplasty on peri-operative complication rates, revision rates and mortality. Method: A search strategy was developed to identify all relevant citations from the MEDLINE, EMBASE and COCHRANE databases and the unpublished literature. Assessment of the studies for methodological quality and content was conducted independently by two reviewers who extracted all relevant information from the included studies. The data was categorized into subgroups and pooled using the DerSimonian and Laird’s random effects model. Results: A total of 18 articles were identified from 873 potentially relevant titles and selected for inclusion in the primary meta-analyses. The incidence of mortality was significantly higher in the simultaneous group at 30 days (Risk Ratio (RR) 3.31, 95% Confidence Interval (CI) 1.766.23, p = 0.001, I2 = 33%, sample size (n) = 67,784 patients), 3 months (RR 2.45, 95% CI 2.15 – 2.79, p < 0.001, I2 = 0%, n = 66,474 patients), and 1 year (RR 1.85, 95% CI 1.66 – 2.06, p<0.001, I2 = 0%, n = 65,322 patients) post-surgery. The rate of revision surgery was significantly lower in the simultaneous group (RR 0.36, 95% CI 0.16 – 0.81, p<0.05, n = 752 patients) two years post-surgery. There was no increased risk of deep vein thrombosis, cardiac complication, pulmonary embolism, or infection rates in either comparison group. Conclusion: The results of the analysis suggest that simultaneous bilateral total knee arthroplasty has a significantly higher rate of mortality at 30 days, 3 months. and 1 year postsurgery, and a significantly lower rate of revision surgery two years post surgery. These results should be interpreted with caution due to the inclusion of nonrandomized studies in the primary meta-analyses. 64: The Ottawa Experience using a Modular Femoral Neck System for Primary Total Hip Arthroplasty Emmanuel M Illical, ON; Paul E Beaulé, ON; Robert Feibel, ON; Peter Thurston, ON; Paul Kim, ON; Wade T Gofton, ON Purpose: Modular neck systems for total hip arthoplasty offer the ability to alter femoral version, offset, and leg length independently from the femoral stem that has been inserted. However, concerns have been raised about neck fracture as well as corrosion at the modular head-neck interface. The purpose of this study was to describe the experience of using a modular neck system at our institution and to report any potential complications. Method: Between January 2006 and June 2011, 580 primary total hip arthroplasties were performed at our center using either a flat tapered wedge geometry femoral stem or rectangular tapered stem with a titanium modular neck option (Profemur TL and Z) by five different surgeons with 3 surgical approaches: posterior, anterior, or lateral. Implant details were recorded in a database at the time of surgery and the patients are being prospectively followed for any complications associated with the modular femoral neck. Results: The patient demographics were as follows: mean age 61.5 +/- 12 years; mean height 168 +/- 12 cm; mean weight 81 +/- 19 kg; 318 females (55%) and 262 males (45%). A neutral neck was used in only 18.6% of cases (106/580). The most common neck used was the varus/valgus accounting for 56.9% of cases (330/580). The anteverted/retroverted options accounted for 12.9% of cases (77/580). The anteverted/retroverted and varus/valgus option accounting for 11.2% of cases (65/580). Ninety two percent (533/580) of necks implanted were short with 57% (302/533) being female. Only 8% (47/580) of necks were long with 66% (31/47) being males. There were no complications associated with the modular femoral neck at the latest follow up for all patients. Conclusion: A significant number of patients benefitted from the modular necks in optimizing their biomechanical reconstruction. Unlike previous reports, at mid-term follow-up there were no complications associated with the modular femoral neck in our series with only 8% of patients requiring the long neck options. Further long term follow-up is required to determine if other failure modes will occur. 65: A Pilot Randomised Controlled Trial Evaluating the Effectiveness of Virtual Reality Arthroscopic Knee Training in an Orthopaedic Residency Program Jesse Alan Shantz, US; Jeff Leiter, MB; Jason A Old, MB; Gregory Stranges, MB; Jamie H Dubberley, MB; Peter B MacDonald, MB Purpose: The purpose of this study was to validate the use of a virtual reality haptic knee simulator with embedded skills mentor in arthroscopic education through a pilot randomized controlled trial. A previously validated global arthroscopic skills assessment was used to determine the effects of an arthroscopic virtual reality surgical simulator on the development of arthroscopic skills assessed during a diagnostic arthroscopy performed on a cadaveric knee. Method: A total of 14 residents were assessed on pre-study ability to perform a diagnostic knee arthroscopy using a procedure-specific checklist and global assessment of skills after consenting to this IRB-approved study. Participants were then stratified by arthroscopic experience and randomized to receive a VR simulator training program or standard training. The simulator-trained group completed a computer-mentored course (ToLTech, Aurora, CO) including periodic skills assessments within six week training period. At the conclusion of the VR simulator training period all participants were again assessed on their ability to perform a diagnostic knee arthroscopy and retention of skills was assessed after a six week washout period. Results were presented as mean difference skills with differences between groups assessed using the Student’s t-statistic and presented as 95% confidence intervals. Results: Pre-randomization skills in the groups were not significantly different. The control group had a larger number of junior residents. There was a wide variation in adherence to the mentored simulator program. Mean difference of global skills was not found to be different between VR simulator-trained and control groups (p=0.52). The retention of skills was also not different between the two groups (p=0.15). Of note, both groups showed significant improvements in skills during the study and retained those improvements after six weeks (mean improvement 16.5%, 95% C.I. 6.4%-26.5%). Based on this pilot a group size of 51 participants would be necessary to show a statistically significant difference in skills improvement after this educational intervention. Conclusion: The results of this study suggest there is no difference in arthroscopic skills improvement after six weeks of simulator training as measured by a global objective arthroscopic skills assessment. This finding was tempered by the variable adherence to simulator training in the treatment group. Of note, the average skill of participants showed a statistically significant improvement equal to the difference between junior-level skills to seniorlevel skills. Future studies need to look at the ability of this training program to improve orientation to arthroscopy-based rotations. 66: Casting Simulation in Orthopaedics: Improving a Lost Art M Lucas Murnaghan, ON; Joel Moktar, ON; Charles A Popkin, ON; Andrew Howard, ON Purpose: With decreased work hours and an increased role of operative fixation for distal radius fractures, orthopedic trainees are losing experience and expertise in proper cast application. Technical deficiencies in casting skill have been demonstrated to result in higher rates of re-displacement and cast specific complications. Although this loss of ability has been described and lamented, no formal education modules exist to instruct or evaluate casting technique without the use of a patient. Existing educational methods are insufficient as they cannot objectively measure cast quality and offer limited practice opportunities. Method: A novel educational module that simulates the required reduction and appropriate cast application for a distal radius fracture in a synthetic forearm model was developed. An Objective Structured Assessment of Technical Skill (OSATS) was created using Delphi methodology involving nine content experts (five Orthopedic Surgeons and four Orthopedic Technologists). Nine de-indentified videos of cast application were recorded and utilized to test the newly developed OSATS and Modified Global Rating Scale (MGRS) for reliability and validity. The casting simulator participants were grouped by training level. Results: The OSATS scores improved with increasing level of training: 9.3 for Medical students (MS), 17.5 for Residents (R) and 18.9 for Fellows/Techs (F/T) (p <0.05, F score 6.12) tested with ANOVA and confirmed with Tukey test. MGRS Performance similarly improved with level of training: 1.44 MS, 3.13 R and 3.54 F/T (p <0.05, F score 6.37). Reliability was rated as high by Intraclass correlation. Inter-rater reliability for the OSATS, GRS Performance and GRS Final Product was 0.85, 0.81 and 0.78 respectively and intra-rater reliability was 0.88, 0.85 and 0.81 respectively. Conclusion: This casting simulation model and evaluation instrument is a valid assessment of objective skill in applying a short arm cast for a distal radius fracture. Scores increased with level of orthopedic training and casting experience. This simulator will allow for improved teaching and learning of casting techniques to medical students and residents across a variety of disciplines. The improved application of short-arm casts for distal radius fractures will allow for better patient care and subsequent clinical outcome. 67: Developing a Model for Simulator Training and Evaluation of Arthroscopic Skills Ivan H Wong, ON; David Newman, ON; Matthew Denkers, ON; Forough Farrokhyar, ON Purpose: The purpose of this study was to develop a simulator-teaching model for knot tying and objectively evaluate the acquired skills of surgical trainees. Method: Surgical trainees were enrolled in an observational study (Phase I, n=32). Subjects viewed an instructional video and pretested on a novel knot-tying simulator by attempting to tie three arthroscopic SMC knots in 10 minutes. Each knot was objectively scored based on a previously published formula (Derossis et al 1998). Subjects were assessed twice with intermittent practice and feedback during a 90-minute lab session. This experiment was repeated 6 months later to determine retention of acquired skills (Phase II, n=25). The mean proficiency score with standard deviation and mean difference with 95% confidence intervals (CI) are reported; a generalized linear regression model was used for analysis. Results: Expert derived proficiency score (489) was used as the standard for competency. Phase I, the mean proficiency score of 32 trainees was 67 (119), 239 (201) and 334 (140) at baseline, assessment 1 and assessment 2, respectively. The mean proficiency score of 334 (140) was significantly lower than expert proficiency score (-155 (95% CI: -205.5, -104.5), p<.001). After a 6-month interval (Phase II), these skills were not retained. The mean proficiency score difference from Phase I assessment 2 to Phase II baseline was -222.8 (95% CI: -302.7, -142.9, p<.001). At Phase II, the mean proficiency score of 25 trainees increased from 110 (138) at baseline to 362(118) at assessment 1 and 408 (99) at assessment 2. The mean proficiency score was significantly lower than expert proficiency score (-81 (95% CI: 122, -41), p<.001). Adjusting for year of residency, gender, age, previous experience and phase I and II training model, the simulator training model (p<.001) and year of residency (p=.004) were the best predictors of proficiency scores improvement. Conclusion: Simulator training models have a place in orthopaedic education for teaching basic arthroscopic skills. However, frequent practice is necessary to ensure retention of acquired skills. 68: Implementation of a Novel Night Float Call System: Resident Satisfaction and Quality of Life Stephen M Mann, ON; Graham Fedorak, ON; Daniel P Borschneck, ON; Mark M Harrison, ON Purpose: To evaluate the satisfaction of orthopaedic residents with a novel call system after its implementation at an Ontario tertiary care centre, and to measure quality of life following this implementation. Method: Due to relatively small program size (16 residents) and clinically active attending surgeons, compliance with PAIRO duty-hour guidelines has historically been problematic at our institution. In an effort to facilitate residents’ ability to go home post-call without significant disruption of ongoing clinical activities, a novel call system was adopted. A “night float” resident was designated, and was assigned only to on-call duties for a full four-week (one block) rotation. During this time, the night float resident was not attached to any of the regular orthopaedic services and had no additional clinical responsibilities. Duty hours were 1700h to 0600h each day from Sunday to Friday, with cessation of clinical duties on Friday morning until Sunday evening. Friday and Saturday call were performed by other residents in the regular 24hour fashion, as the subsequent days, being weekends, had no clinical duties and residents could easily be excused post-call. In addition, other residents were on call each evening of the week until 2300h, at which point they were excused. This allowed for additional manpower during typically busy evening hours, leaving the night float resident on call alone from 2300h to 0600h, and permitting the residents who were on call only until 2300 to be present for the next clinical day. After implementation of this call system, questionnaires were administered to onservice residents. These included the SF36 and those used by Zahrai et al to address topics such as education, stress, work-related problems, and miscellaneous concerns. Qualitative feedback was also solicited from nursing and ER staff. Results: Quality of life for residents on the night float block did not demonstrate significant improvement over baseline values established by Zahrai et al. However, for those residents who were on service while another resident was performing night float duties, quality of life was substantially improved. Overall satisfaction with the system was high among residents, nurses, and the emergency department. Improved resident mood and greater cheerfulness were subjectively commented upon. In addition, attending staff found that this system facilitated effective feedback. At our institution, attending staff perform call one week at a time, and they were able to continuously interact with one resident over that time, rather than with a different resident each night. Conclusion: This call system results in improved resident quality of life and widespread overall satisfaction while allowing adherence to PAIRO duty-hour restrictions without undue disruption of clinical activities, and may be considered as a viable alternative to traditional call formats. Follow up data as more residents experience the night float block will be valuable. 69: Occupational Risk in Orthopaedic Surgery: Is the Use of Fluroscopy Hazardous to Your Vision? Marcia L Clark, AB; Roxanne Chow, AB; Chris Rudinsky, AB; Lauren Beaupre, AB; David Otto, AB Purpose: Ionizing radiation, such as that used in fluoroscopy, conventional radiography and computed tomography, in high doses, can lead to the development of cataracts. Although the documented exposure levels to the eyes are low in Orthopaedic Surgery, given the potential risk of even low dose exposures, the ultimate risk to the orthopaedic surgeon is unknown but is potentially valid and serious. The purpose of this study was to determine amongst orthopaedic surgeons and residents in Canada: 1) perceived level of personal risk for cataract formation from ionizing radiation exposure: 2) awareness level regarding the risk of cataract formation due to ionizing radiation exposure: 3) awareness regarding the existence of ICRP and NCRP dose limits for the amount of radiation exposure to the eyes in an occupational setting: 4) current radio-protective practices. Method: A descriptive e-mail survey was administered to members of the Canadian Orthopaedic Association in 2010. Survey design was performed through review of the literature, application of rigorous design principles, expert content review and initial piloting in a local environment. Results: A total of 264 responses were received (1132 distributed questionnaires) for a response rate of 23%. Almost half of the respondents believed that they were at either moderate (n=107;41%) or extreme risk (n=20;8%) for cataract formation as a result of accumulated occupational radiation exposures. Less than 30% of respondents believed that they were either at no risk (n=6;2%) or only minimal risk (n=72;27%). Fifty nine (22%) respondents indicated that they did not have sufficient knowledge to estimate their risk. Almost half of the respondents (n=120;45%) reported having no or minimal awareness that ionizing radiation may contribute to cataractogenesis; almost three-quarters of respondents (n=197;74%) reported having no or minimal awareness that ICRP annual dose limits exist. Most respondents (n=147;56%) were categorized as using low amounts of fluoroscopy/week (≤300 seconds), 78 respondents (30%) as using moderate amounts (301 to 599 seconds /week), and 39 respondents (15%) as using high amounts (≥600 seconds/week). Although most reported that they always use leaded gowns (n=227;86%) and thyroid shields (n=161;61%). 91% of respondents (n=234) indicated that they never use radio-protective eyewear. Of those who indicated that they had never used radio-protective eyewear, the most commonly cited reasons were that the institution did not supply them, that the respondent did not know where to purchase them, and that the respondent was unaware of a possible cataract risk. The association between perceived risk and awareness was statistically significant (p<0.001). Conclusion: This study demonstrated a large information deficit among orthopaedic surgeons with respect to their awareness of the potential risk of cataractogenesis due to radiation exposure and of the existence of dose limits. 70: On-Line Vs Paper Format Learning: Identifying Inflammatory Arthritis Early: Randomized Control Trial Veronica Wadey, ON; Heather McDonald-Blumer, ON; Alfred Cividino, ON; Jean Wessel, ON; Deborah Kopansky-Giles, ON; David Levy, ON; Jodi Herold, ON; Douglas Archibald, ON Purpose: The purpose of this study was to determine whether medical residents learning by case simulation using on-line learning technology (OLT) on “sore hands, sore feet”, would have a greater improvement in knowledge, skills and satisfaction in learning how to identify patients with early-stage inflammatory arthritis than medical residents using a paper format (PF) only. Method: A randomized control trial (RCT) was conducted with family medicine and rheumatology residents followed by focus group interviews. An orientation session with pre/post test questionnaires and analyses was completed. Thirty-one subjects completed the “Sore Hands, Sore Feet” (SHSF) learning module and were randomized into either the OLT or PF groups. Twelve residents completed the module online (OLT - experimental group) and 19 completed the paper-based format (PF - control group). Each of these learning methods underwent full content review prior to this trial. Data was analyzed based on: Time 1 (PreModule), Time 2 (Post-Module) and Time 3 (3 month Follow-up). The OLT group did not complete the Pre-Module assessment; however 19 in the paper-based group did so. Repeated Measures ANOVA was used to assess the extent to which there was learning in the PF group from Time 1 to Time 2. One-way ANOVA was used to assess the effect of learning format on Post-Module test scores. A separate Repeated Measures ANOVA was run to determine the effect of format (OLT versus PF) on retention from Time 2 to Time 3. Two focus groups were conducted Results: No significant difference among family medicine and rheumatology residents in either the online (OLT) and paper format (PF) groups (means of 2.60 out of 4 for the OLT group; 2.76 out of 4 for the PF) existed at the beginning of the study. There was a significant increase in scores from Time 1 (11.21/16; SD=2.30) to Time 2 (12.79/16; SD=2.20) for the PF group. At time 2 and time 3, there were no differences in scores between the PF and OLT groups [provide values for the OLT group.] There was a small but statistically significant decrease in scores from Time 2 to Time 3 for BOTH groups (Post-test mean scores equaled 12.58 out of 16; SD=1.78 and Follow-up mean scores equaled 11.97 out of 16; SD=2.09). Findings from the focus group interviews suggested that all residents found the SHSF module to be very informative. Residents learned how to appropriately refer a patient to a rheumatologist and carried out this act during clinical encounters. This may suggest that knowledge transfer was occurring. Conclusion: Overall, the residents learned from both OLT and PF methods and found the SHSF module very informative and were able to retain similar amounts of knowledge regardless of method for learning used. A preference for the online learning resources was expressed by all residents. 71: Selecting Applicants for Residency Training Programs: Can We Predict Their Success? Raman Mundi, ON; Harman Chaudhry, ON; Cheromi Sittambalam, ON; Susan Reid, ON; Brad Petrisor, ON; Mohit Bhandari, ON Purpose: The selection criteria used by residency training programs are varied but typically aim to identify individuals who will excel in their chosen specialty. This meta-analysis assesses common selection criteria used by residency programs for their ability to predict future performance during residency. Method: Three medical databases (MEDLINE, Embase, and PsycInfo), as well as PubMed and reference lists, were screened to select North American studies in all specialties. The following measures of medical student performance were assessed: (1) interview performance, (2) GPA, (3) board exam scores, (4) match list ranking, (5) AOA membership, (6) dean’s letter, (7) reference letters, (8) research experience, (9) medical school prestige, and (10) class rank. A meta-analysis of Pearson’s correlation coefficients was performed to assess the relationship between these characteristics and the following measures of residency performance: (1) Board certification and in-training exam scores (objective measures of cognitive performance); and (2) Faculty and rotations evaluations (subjective measures of cognitive and behavioural performance). Results: From over 2237 potential studies, 32 studies satisfied inclusion criteria. Board exam score (r=0.52, p<0.001) and match list ranking (r=0.59, p=0.002) were strong predictors of objective success in residency, while medical school grades (r=0.30, p<0.001) were moderately correlated to objective success. Although weak in magnitude, medical school grades (r=0.25, p<0.001) and interview performance (r=0.17, p=0.005) were the only characteristics that correlated significantly with subjective measures of success. Membership in AOA, dean’s letters, reference letters, research experience, medical school prestige, and medical school rank failed to predict resident success due to statistical insignificance or insufficient data for analysis. Conclusion: Our findings suggest that applicants with higher board exam scores and higher overall match list ranking tend to have better performance on objective measures of success (exams) during residency training. 72: The Apple Doesn't Fall Far From the Tree: Why Do We Teach the Way We Do, and How Can We Do it Better? Stephen M Mann, ON; Gurjit Sandhu, ON Purpose: To examine attitudes and beliefs among residents and attending surgeons regarding effective and ineffective methods of teaching, and to compare these responses to educational literature. Specifically, the use of role modelling and shame-based learning were addressed. Method: Responses from residents involved in a workshop entitled "Teaching residents how to teach" were compiled over two years and mapped to a literature-based grid of effective and ineffective teaching strategies. Additionally, based on data collected from a pre-survey questionnaire, attending staff from the Department of Surgery were interviewed regarding their teaching habits and strategies, and their responses qualitatively reviewed and compared to the literature. Results: Role modelling was consistently mentioned by residents as an effective teaching strategy. It was also widely used by attending physicians, particularly to convey non-medical expert CanMEDS roles such as communicator and collaborator. Many staff, however, feel that role modelling can be performed subconsciously, leading to arguably inferior translation. Shame-based learning has been a part of surgical education for centuries, but has been demonstrated to be an ineffective means of knowledge transfer. However, the clinical applicability of case-based learning, such as what happens in typical morning trauma rounds, is appreciated and relevant. Additionally, there is wide belief among staff surgeons, and some residents, that the motivation provided by being on the "hot seat" inspires greater academic efforts. Conclusion: Role modelling is an effective means of teaching many of the "softer" or nonmedical expert CanMEDS roles, but it must be consciously employed to be of greatest value. Shame-based learning in the traditional sense has many undesired effects and is not an effective teaching strategy. Many aspects of it, however, such as case-based applicability and immediate feedback, can be applied to relevant teaching methods. 73: The OSCORE (Ottawa Surgical Competency Operating Room Evaluation) - A Validated Tool to Evaluate Surgical Competence Wade T Gofton, ON; Nancy L Dudek, ON; Fadi Balla, ON; Stan Hamstra, ON; Timothy J Wood, ON; Steven R Papp, ON; Shay Seth, ON Purpose: Surgical training programs are responsible for ensuring the competency of their graduates. The formal assessment of a surgical trainee’s ability to safely perform surgical skills is limited to a small portion of the In-training Evaluation Report. Most surgical trainee assessment is based on measures of knowledge (i.e. ‘knows how’). Whereas, the assessment of a trainee’s competence to actually do (i.e. ‘shows how’) the various surgical procedures is limited to a small portion of the In-training Evaluation Report. Most evaluation tools validated to assess surgical procedures usually only assess specific technical procedures. This study involved the assessment of a tool designed to evaluate the competence of a trainee to perform an entire surgical procedure regardless of procedure type. Method: The initial tool was developed by key stakeholders, piloted and in Orthopedic surgery and named the OSCORE. It is a 9-item tool with each item rated on a scale where the maximum score is defined as competent for independent practice. In this study the OSCORE was used in the in the University of Ottawa’s General and Orthopedic Surgery Residency Programs where staff surgeons evaluated residents on ten common procedures. Post-study focus groups were conducted. Results: Thirty-four surgeons completed 163 assessments on 37 residents. An ANOVA analysis demonstrated an effect of postgraduate year (PGY). Post hoc analysis found that total scores for PGY (1-2) were significantly different from PGY 3 (p<0.001) and PGY 3 from PGY (4-5) (p < 0.05). Analysis of the qualitative data indicated the scale was practical and useful for staff and residents. Conclusion: This novel evaluation tool successfully discriminated between junior and senior residents and identified surgical competency across various PGY trainee levels regardless of procedure type. This suggests that the OSCORE is valid for the assessment of trainee operative competency. 74: The University Of Toronto Competency Based Curriculum’s “Orthopaedic Boot Camp”: Examining Retention Rates For Skills Taught Through An Intensive LaboratoryBased Surgical Skills Course Markku T Nousiainen, ON; Ranil Sonnadara, ON; Oleg Safir, ON; Shawn Garbedian, ON; Peter Ferguson, ON; William Kraemer, ON; Benjamin Alman, ON; Richard Reznick, ON Purpose: Prior publications on the University of Toronto Competency Based Curriculum’s (CBC) “Orthopaedic Boot Camp” have shown compelling data that an intensive, laboratorybased course at the beginning of residency training can be highly effective at teaching and developing targeted technical skills. We present data from three groups of residents which examine the retention rates for skills taught in this manner. Method: Three groups of residents were assessed in their ability to perform basic surgical and medical technical skills and the basic principles of AO fracture fixation. The first group (CBC) started their training with a month long ”boot camp” course in basic technical skills. The other two groups were regular stream Junior (JR) and Senior (SR) residents, whose training included no such course. Performance on targeted technical skills was examined using an OSATS examination up to 18 months after the completion the skills course for the CBC group and up to 19 months after the onset of training for the JR group. Results: Data revealed that skill retention rates for the CBC group were excellent (mean GRS scores remained at 4.3 even 18 months after the course). There were also no significant performance differences between the CBC and SR groups (mean GRS scores were 4.3 and 4.4). Both the CBC and SR groups performed significantly better than the JR group (mean GRS score 3.7; F[2,15]=12.269, p<0.001). Conclusion: We conclude that an intensive, laboratory-based course is an extremely effective mechanism for teaching targeted technical skills and that skills taught in this manner can have excellent retention rates. Furthermore, it seems that an early focus on technical skills allows junior residents to perform at the level of senior residents much earlier in training for targeted tasks. Anecdotal reports from faculty suggest that the skills course has greatly enhanced capacity of our CBC residents throughout their training. This training model has now been instituted for all incoming orthopaedic residents in the Division of Orthopaedic Surgery in Toronto. 75: A Survey of Canadian Orthopaedic Surgeons’ Current Approach to Post-operative Fracture Radiographs, and Their Attitude Toward a Simplified Protocol Presenter: Ted V Tufescu, MB Purpose: To determine Canadian Orthopaedic surgeons’ current protocol for early postoperative radiographs of stable, internally fixed fractures, and their willingness to adopt a simplified protocol. Method: Members of the Canadian Orthopaedic Association were invited to participate in an electronic survey via email. Subjects were presented with five fractures: femur and tibia midshaft fractures treated with intra-medullary nails, and forearm, humerus and ankle fractures treated with compression plating. The survey documented selected demographic data, the surgeon’s current post-operative protocol for radiographs, and explored whether surgeons would consider a simplified protocol. Results were analyzed and means were reported. Results: Eight hundred and twenty two invitations were emailed, of which 400 were opened. Two hundred and forty three surgeons followed the link and completed the survey. The majority of surgeons were practicing in Canada (91%), managed some trauma (91%), but were not dedicated trauma specialists (82%). Surgeons of all experience levels were equally represented with 23% having zero to five years experience, 23% five to 10 years, 26% 10 to 20 years and 29% with over 20 years of experience. Sixty six percent of respondents currently acquire immediate post-operative radiographs for femur and tibia fractures treated with intramedullary nails, and 62% repeat them at two weeks. Fifty one percent of respondents currently acquire immediate post-operative radiographs for forearm, humerus and ankle fractures treated with open reduction and internal fixation, while 69% repeat them at two weeks. Of respondents who currently acquire radiographs, 33% would consider foregoing immediate post-operative radiographs after intramedullary nailing of femur and tibia fractures, while 25% would consider foregoing these at two weeks. In the group currently acquiring radiographs, 58% would consider foregoing radiographs immediately after open reduction and internal fixation of forearm, humerus and ankle fractures, while 24% would consider foregoing these at two weeks. Conclusion: This survey demonstrates that a large portion of Canadian Orthopaedic surgeons already do not acquire radiographs until six weeks after internal fixation of selected fractures, and a large portion of those who do, would consider a change in practice to a simplified protocol. These findings support investigating the safety and cost efficiency of a simplified post-operative radiographic protocol. 76: Implant Choices in the Treatment of Tibial Open Fractures: Minimizing the Rate of Infection Sebastian R Rodriguez-Elizalde, ON; Omar Desouki, ON; Bheeshma Ravi, ON; Richard Jenksinon, ON Purpose: To compare the infection rates of two different surgical techniques: intra-medullary tibial nailing versus plating.Orthopaedic fracture management has evolved in both surgical approach and technique over the last twenty years. A respect for soft tissues, better orthopaedic implants and minimally-invasive techniques (MIS) have helped improve union rates in open tibial fractures. However, little has been studied in the modern era to determine if these techniques improve infection outcomes in open fracture patients. We hypothesized tibial intra-medullary nailing vs plating (open or MIS) in the management of open fractures would result in less complications (deep infections), if the fracture pattern were amenable to either surgical technique. Method: Our institution has an ongoing orthopaedic trauma database, which collects various parameters on all patients prospectively. The database was reviewed to identify all open tibial fractures over the last 10 years at our institution. All patients were treated by fellowship trained orthopaedic trauma surgeons or fellows in an academic setting. 220 were initially identified according to OHIP (Canadian provincial universal health insurance) coding. After reviewing all charts and radiographs, we eliminated patients who were deceased (as a result of their initial trauma), had isolated ankle or fibular fractures, or were treated definitively by other methods (ex- fix). This left us with a cohort of 135 patients to analyze. All radiographs were reviewed twice: once by an attending orthopaedic surgeon and once by a trainee (resident or fellow). The initial fracture patten was analyzed to determine if IM nailing was an option in all patients treated via plate fixation. Results: Of the 135 open tibial fractures, 88 were definitively treated by IM nail fixation, and 47 were plated. In total, of the 18 patients that went on to develop documented deep infection, eight were treated by IM nail, and ten by plate fixation. We then reviewed all initial fracture pattern radiographs to determine if an IM device could have been used as definitive fixation instead of plating, using strict inclusion criteria. This review demonstrated that ten of the 47 patients treated definitively with plate fixation could have been nailed (21.3%). Of these, 3 (30%) developed deep infection. Conclusion: In conclusion, we demonstrated that most open tibial fractures are treated via IM nail fixation (65.2 % vs 34.8%) when compared to plate fixation. Ten percent of those treated with IM nails developed infection, compared to 27% of those with plates. Of the 47 patients treated with plating, 10 could have been treated with an IM device, and of those 3 (30%) went on to develop deep infection. This demonstrated rate of infection is three times higher than those treated via IM nailing. Overall implant choice is guided by many factors, many not in a surgeon’s control. However, if there is an option to use an IM device, it should be strongly considered. 77: Management of Tibial Plateau Fractures in Patients 60 Years and Older with Staged Total Knee Arthroplasty Peter Dust , SK; William Dust, SK Purpose: In older patients treatment of tibial plateau fractures with ORIF, total knee arthroplasty (TKA) acutely or as salvage have proven unpredictable with high complication rates. The purpose of this study is to report the results of patients over 60 managed with a staged protocol of TKA. Method: Patients are placed in a hinged rehabilitation brace. Immediate range of motion (ROM) with full weight bearing is encouraged. Hospital admission is avoided when possible. After six weeks the brace is weaned. Twelve weeks post fracture the brace is discontinued and full activities are encouraged. Six months post fracture all are offered a TKA. If TKA is declined patients are followed. Follow-up (FU) assessment included a Knee Society score and radiographs which included a three foot lower extremity film. Results: Twenty three patients were managed with this protocol. One patient was lost to FU after three months and not further included. Continued Nonoperative Management. Fourteen patients, average FU 28 months, declined TKA. There were 11 Schatzker II and three Schatzker V or VI fractures. The average amount of joint depression was 13 mm (range 0-19). The patient with no joint depression (Schatzker VI) had an articular gap of 10 mm. The mechanical axis ranged from 10 degrees varus to 15 degrees valgus. The average knee score was 81. The average ROM was 5-120 degrees flexion. TKA Eight had a posterior stabilized TKA. The decision to proceed with TKA was made at an average of five months post fracture (range 3-7 months). The average joint depression was 23 mm (range 10-32), the average preop knee score 46. At 21 months average FU the average knee score was 76. The average preop ROM was 10-110 degrees, postop 5-105 degrees. All knees coming to TKA had valgus alignment, the average preop mechanical axis 13 degrees (range 4-27). Postop average two degrees varus (range 0-4). Detailed surgical notes included a subjective assessment of the degree of difficulty compared to a routine TKA. Four knees, all Schatzker II fractures were considered only slightly more difficult. These all had healed fractures with a central defect that either did not need management or were managed with morsellized autograft. No augments or stems were required. In the remainder three metal augments and four stems were used. Two were considered difficult. One a Schatzker II fracture with 27 degrees mechanical valgus (FU knee score 82, 5-115 degrees flexion). The other a high energy Schatzker VI with 18 degrees mechanical valgus with extensive malunited bone that needed to be removed (FU knee score 98, 5-115 degrees flexion). No complications have occurred in the TKA group. Conclusion: Staged TKA is a reasonable treatment option for these difficult fractures and is capable of producing good results with a low complication rate. Health care costs are minimized by avoiding CT scans, minimizing or avoiding hospital admissions and performing surgery only on patients who demonstrate a need for it. 78: Management of Unstable Proximal Femoral Fractures with Reverse Locked Distal Femoral Plates- Our Experience in 21 Patients Pankaj Mahndra, IN; Rajnish Garg, IN; Harpal Singh Selhi, IN Purpose: The optimal management of unstable proximal femoral fractures is controversial. In this prospective study, we assessed the outcomes of reverse distal femoral locked plates for treatment of comminuted unstable proximal femoral fractures Method: From June 2005 to April 2009, 21 patients with unstable proximal femoral fractures that were assessed to be difficult to nail were managed with reverse -distal femur plates, which included (1) subtrochanteric fractures with extension into the piriform fossa, (2) short skeletons with narrow femoral canals, (3) adolescents with open physes, (4) severely bowed or deformed femurs and (5) Indian proximal femur which are too small to accept a nail. These patients were enrolled in this study. There were eight females and 13 males, with a median age of 52 years (range, 18-65 years). The average follow-up period was 24 (range, 12-32) months. The outcome was assessed on the basis of bony union, neck shaft angle, any residual deformity, fixation failure, metal work failure, infection, limb length discrepancy and return to pre injury functional status. Results: Union was achieved in 18 out of 21 patients. The average time to union was 6 months (range 3- 12 months). We had on implant breakage, which was revised for fixation and bone grafting and the fracture proceeded to union at 9 months post injury .One of our cases had loosening of proximal screws but the fracture united in 3 months in some varus with shortening. Another patient had shortening of more than 1.5 cms, the cause of which was varus mal reduction at the fracture site. One of the patients with the deformity complained of significant hip pain. Superficial infection occurred in one patient which healed after debridement and a short course of I- V antibiotics. Conclusion: Taking into consideration the simple surgical technique, good healing rate and minimum complications we strongly recommend the use of reverse locked distal femoral plates in carefully selected patients 79: Operative versus Non-operative Treatment of Acute Dislocations of the Acromioclavicluar Joint: Results of a Multi-centre Randomized, Prospective Clinical Trial Stéphane Pelet, QC; Michael D McKee, ON; Canadian Orthopaedic Trauma Society (COTS), ON Purpose: Purpose: The optimal treatment for acute dislocation of the acromio-clavicular (AC) joint remains unclear. Both surgical repair and non-operative treatment have been advocated, but prior randomized trials did not reveal any significant differences between groups. However, these studies used inferior surgical techniques and surgeon-based or radiographic outcome measures. We sought to perform a randomized clinical trial of operative versus non-operative treatment of acute AC joint dislocations using modern surgical fixation and patient-based outcome measures. Method: Methods: We performed a prospective, multi-center, randomized clinical trial comparing operative repair with hook plate fixation versus non-operative treatment for acute (< three weeks old) complete (Grades III, IV, V) dislocations of the AC joint. The primary outcome measure was the Disabilities of the Arm, Shoulder, and Hand (DASH) score at one year postinjury. Assessment also included a complete clinical assessment, the Constant score, the SF36 score, and a radiographic evaluation at 6 weeks, and at three, six, twelve, and twenty-four months. Results: Results: Eighty-three patients were randomized (operative repair 40, non-operative treatment 43). There were no demographic differences between the two groups (operative: male/female 36/4, non-operative 42/1, p=0.279, mean age operative group: 38.7 years, nonoperative group: 37.3 years, p=0.778, dominant arm: operative group 24, non-operative 26, p=0.823, smoker: operative group 10, non-operative 16, p=0.338). The mechanisms of injury were similar between the two groups. DASH scores (a disability score – lower score is better) were significantly better in the non-operative group at six weeks (operative 46, non-operative 31, p=0.007), three months (operative 28, non-operative 16, p=0.01), and six months (operative 15, non-operative 8, p=0.03). There were no significant differences between the groups at one (operative 10, non-operative 6, p=0.189), or two (operative 3, non-operative 4, p=0.893) years post-injury. Similar values were seen for Constant scores at six weeks (operative 52, non-operative 75, p=0.000), three months (operative 69, non-operative 85, p=0.001), six months (operative 83, non-operative 92, p=0.001) one year (operative 90, nonoperative 94, p=0.006) and two years (operative 93, non-operative 93, p=0.770). Additionally, the re-operation rate was significantly lower in the non-operative group (p<0.05). Conclusion: Discussion: Hook plate fixation is not superior to non-operative treatment for the treatment of acute, complete dislocations of the AC joint. The non-operative group had better early scores, although both groups improved from a significant level of initial disability to a good or excellent result (mean DASH score 3, mean Constant score 93) at two years. At the present time, there is no clear evidence that operative treatment with hook plate fixation improves short or long-term outcome for complete AC joint dislocations. 80: Radiographic Outcomes of Closed Diphyseal Femur Fractures Treated with the SIGN Nail Sasha Carsen, ON; Sam Park, ON; David Simon, ON; Robert Feibel, ON Purpose: The burden of orthopaedic trauma in the developing world is significant and disproportionate, both in health and economic terms. The Surgical Implant Generation Network (SIGN) has developed and made available to surgeons in resource-limited settings a low-cost intra-medullary prosthesis for use in the treatment of fractures of the femur and the tibia, with the prosthesis and necessary tools donated. Despite the clinical success of the SIGN Nail, with more than 50,000 surgeries performed, there has been very little research examining outcomes. Our primary purpose was to examine the post-operative radiographs of closed diaphyseal femur fractures treated with the SIGN Nail to assess for alignment. Our secondary goal was to assess the functionality and robustness of data in the SIGN database. Method: A retrospective review was undertaken of patients treated with the standard SIGN Nail, which at the time of the study totaled 32,362. Further inclusion criteria included the treatment of a diaphyseal femur fracture. Exclusion criteria included open fractures and those without post-operative radiographs. A random number generator was used to randomly select 500 cases for analysis, and the following information was recorded: Location of the fracture within the diaphysis, fracture classification (AO/OTA classification), degree of comminution (Winquist classification), and patient demographics. Measurements of alignment were then made based on the Antero-Posterior and Lateral radiographs, with mal-alignment defined conservatively as deformity in either the saggital or coronal plane greater than 5 degrees. The quality of radiographs for each case was graded based on adequacy for visualization of the fracture, the femur, and the ability to measure alignment in orthogonal planes. Results: The incidence of mal-alignment in post-operative radiographs was found to be 8.4%. More than 90% of reviewed radiographs were of acceptable or good quality. Degree of comminution was found to be an independent predictor of angulation and mal-alignment. Conclusion: The incidence of malalignment in femoral fractures treated with the SIGN Nail closely approximated the incidence previously reported in the literature for a North American trauma centre. This is an encouraging finding, and provides support for the continued and expanded use of the SIGN prosthesis throughout the developing world. Additionally, the SIGN database, which is populated by data submitted by SIGN surgeons around the world, was found to be a satisfactory resource for the purpose of retrospective research 81: The Evaluation of a New Measure for Assessing Healing in Lower Extremity Fractures Brad Petrisor, ON; Mohit Bhandari, ON; Scott M Wasserman, CA; Nicole Yurgin, CA; Ricardo Dent, CA; Shelia Sprague, ON Purpose: The recently developed Functional Index for Intramedullary Nailed Tibial Fractures (FIX-IT) measure provides a standardized approach to assess weightbearing and pain in lower extremity fractures. The objective was to evaluate inter-rater reliability and construct validity of the FIX-IT measure. Method: A cross-sectional study of 50 patients with lower extremity fractures across different stages of healing was conducted in 2009. This was a convenience sample and patients were recruited from a single site in Canada. The clinicians were asked to assess whether the items of FIX-IT were ‘essential’, ‘useful’, or ‘not needed’ to provide preliminary construct validity of the FIX-IT measure. Inter-rater reliability of the raters’ scores was assessed using inter-class correlation coefficients (ICCs). Convergent validity was evaluated by Pearson’s correlations between FIX-IT and the SF-36 physical component summary, physical function subscale, and role-physical subscale scores. Results: The overall inter-rater reliability for the total FIX-IT score was 0.879 (95% CI, 0.8280.921). All of the clinicians rated each of the four procedures as either ‘essential’ or ‘useful’. The correlations between the FIX-IT score and the SF-36 ranged from: 0.682 to 0.770 for the physical component summary score, from 0.681 to 0.758 for the physical function subscale, and from 0.677 to 0.786 for the role-physical subscale. Conclusion: The FIX-IT score had high inter-rater agreement across multiple examiners and correlates with the physical scores of the SF-36. Clinicians rated all of the procedures evaluated in FIX-IT as useful in measuring healing for tibia fracture patients. 82: TRial to Evaluate UltraSound in the Treatment of Tibial Fractures (TRUST): A Pilot Study Brad Petrisor, ON; Jason W Busse, ON; TRUST Investigators, ON; Mohit Bhandari, ON Purpose: Tibial fractures are associated with a prolonged recovery period. While results of a number of small randomized trials have suggested that low-intensity pulsed ultrasound (LIPUS) accelerates fracture healing, inferences about functional gains remain weak. The purpose of the present pilot randomized trial was to assess the feasibility of a definitive trial to determine the effect of LIPUS on functional and clinical outcomes in operatively treated tibial shaft fractures. Method: We conducted a multicentre, blinded pilot randomized trial of 51 skeletally mature adults with operatively managed tibial fractures who were treated with either LIPUS or a deactivated LIPUS device. The goals of our pilot study were to determine recruitment rates in individual centers, determine investigators’ ability to adhere to study protocol and data collection procedures, determine our ability to achieve close to 100% follow-up rates, and determine the degree to which patients were compliant with treatment. Our primary outcome measure was physical function as measured by the Short Form-36 physical component summary (SF-36 PCS) score. Our secondary outcomes included the Health Utilities Index-III (HUI-III), the Short Musculoskeletal Functional Assessment (SMFA) measure, time to radiographic healing, rates of malunion and nonunion, and rates of secondary procedures (operative and non-operative). Results: A total of 51 patients were randomized; 23 to LIPUS and 28 to a sham device. Our overall rate of recruitment was approximately 0.8 patients per month, and site investigators successfully adhered to the study protocol and procedures. Forty-three patients (84%) completed one year of follow-up. Patient compliance with use of the ultrasound device was high, with 76% (n=39) demonstrating full compliance and 24% (n=12) demonstrating greater than 50% compliance. Both SF-36 PCS scores (mean difference 6.6, 95% confidence interval 0.1 to 13.0) and HUI-III scores (mean difference 0.20, 95% confidence interval 0.01 to 0.39) demonstrated a significant advantage in favour of LIPUS at the 6-month follow-up (p=0.046 and p=0.035 respectively). Other outcome measures were not significant between treatment arms. Tibia fractures at risk, demonstrated delayed functional recovery versus fractures not at risk, and this difference was significant at 9 and 12 months of follow-up (p<0.001 and p=0.03 respectively). Conclusion: Our pilot study supports the feasibility of a definitive trial. A pivotal trial of 500 patients to resolve uncertainty around our pilot trial estimates of function gains, radiographic fracture healing, and reoperations is currently underway. 83: Unstable Chest Wall Injuries: A National Trauma Databank Analysis of Flail Chest Injuries Niloofar Dehghan, ON; Charles de Mestral, ON; Michael D McKee, ON; Avery Nathens, ON Purpose: Rib fractures are common injuries and occur in 39% of patients with blunt chest trauma. Up to 15% of these cause a flail chest, and lead to chest wall instability. Chest wall instability can lead to severe pulmonary restriction, need for intubation and mechanical ventilation, and high rates of pneumonia, barotrauma, sepsis, ICU stay and death. These injuries are commonly treated non-operatively with mechanical ventilation and pain management as needed; however, the literature suggests better outcome with surgical fixation. Our goal was to evaluate the current practices, morbidity, and mortality of patients with flail chest, to aid in development of an interventional trial evaluating surgical fixation. Method: The National Trauma Databank (the largest aggregation of US/Canadian trauma registry), was used for retrospective analysis of the injury patterns, management and clinical outcomes associated with flail chest injuries. Patients with a flail chest injury admitted from 2007 to 2009 were included for analysis. Outcomes include treatment with surgical fixation or epidural catheter use; number of days on mechanical ventilator; days in ICU; days in hospital, rates of pneumonia; tracheostomy; chest tube placement; and death. Results: In total 354,945 adults with ISS>9 were admitted to 199 trauma centers from 20072009. Flail chest was identified in 3467 patients. The average age at time of injury was 52 years, with 77% male, and 33% female. The mean ISS was 31, and the most common mechanism of injury (79%) was motor vehicle collision. Bad head injury was present in 15% of patients (defined as AIS>3 or GCS-motor <5), while 54% had lung contusions. Treatment practices included epidural catheter use in 8%, and surgical fixation of the chest wall in 1% of patients. Mechanical ventilation was required in 59%, for an average of 12.1 days. ICU admission was required in 82% of patients, for an average of 12 days. Mean length of hospital stay was 16.6 days. Chest tubes were utilized in 44%, and 21% of patients required a tracheostomy. Complications included pneumonia 21%, ARDS 14%, sepsis 7%, and death in 16% of the population. Due to the low prevalence of patients treated with surgical fixation or epidural catheter use, statistical analysis comparing them to patients who did not receive these interventions was not performed. Conclusion: Patients who have sustained a flail chest have significant morbidity (ICU admission 82%, mechanical ventilation 59%, chest tube 44%, tracheostomy 21%, ARDS 14%, sepsis 7%), and high rate of mortality (16%), with current non-operative treatment methods. Prior small randomized trials have suggested dramatic improvements with surgical fixation of these injuries, although this practice is neither widely accepted nor practiced in North America, with only 1% of flail chests being surgically treated. Based on this study, we have initiated a multi-center, randomized trial of surgical fixation versus non-operative care for trauma patients with flail chest injuries. 84: Using a Checklist Improves Agreement between Radiologists and Orthopaedic Surgeons about Hip Fracture Healing Brad Petrisor, ON; Mohit Bhandari, ON; Olufemi Ayeni, ON; Simrit Bains, ON; Rajesh Chakravertty, ON; Meg Chiavaras, ON; Hema Choudur, ON; Naveen Parasu, ON; Sheila Sprague, ON Purpose: The assessment of fracture healing following intertrochanteric fracture fixation is highly variable with no validated standards. The purpose of the present study was to determine 1) the reliability of intertrochanteric fracture healing assessment and 2) the assessment of a novel radiographic scoring system for hip fractures. Method: A panel of 6 reviewers (3 musculoskeletal radiologists, 3 orthopaedic surgeons) assessed fracture healing for 150 cases of intertrochanteric fractures at two separate time points with a time lapse of 4 weeks. Reviewers, blinded to the date of imaging, assessed overall healing from two orthogonal radiographs for each patient at a single time point. Patients were at various stages of healing. Reviewers also scored each fracture on a scale from 10 to 30 using a Radiographic Union Scale for Hip (RUSH) form. This involved the assessment of cortical bridging, and the disappearance of cortical fracture lucency. Two trabecular indices were also scored, one based on consolidation and the other using fracture line disappearance. The quantity of callus formation was also scored. Results: Overall, inter-rater agreement for the impression of fracture healing between reviewer groups was fair [intraclass correlation coefficient (ICC) = 0.34, 95% confidence interval (CI): 0.11-0.52]. Agreement within the radiologist group was higher than the surgeon group (0.60 vs. 0.24). Use of the RUSH score improved overall agreement between groups to substantial (ICC=0.66, 95% CI: 0.53-0.75). Intra-rater agreement was almost perfect for fracture healing (ICC=0.84, 95% CI: 0.74-0.91) and substantial for RUSH score (ICC=0.69, 95% CI: 0.35-0.84). Reviewers’ subjective assessments of healing seemed to be highly correlated with the overall RUSH score and their assessment of healing of the medial cortex bridging (Pearson’s correlation (r) = 0.72 and 0.53 respectively). The medial cortex bridging was especially correlated with healing among radiologists versus surgeons (r=0.53 vs. 0.42). Conclusion: The RUSH radiographic score achieved higher inter-observer agreement among reviewers than subjective assessments. Higher RUSH scores and healing of the medial cortex correlated with subjective assessment of overall fracture healing. Studies evaluating agreement with a temporal sequence of the radiographs and the addition of clinical information may enhance agreement between reviewers. 85 A Finite Element Contact Analysis of Axisymmetric and Anatomical Radial Head Hemiarthroplasty G Daniel G Langohr, ON; Ryan Willing, ON; John B Medley, ON; Graham JW King, ON; James A Johnson, ON Purpose: Radial head (RH) fractures are common and treatment may require the use of a hemiarthroplasty prosthesis that articulates with natural cartilage at the radiocapitellar and radio-ulnar joints. Current RH prostheses have been reported to decrease joint contact area by up to two-thirds, which could contribute to degradation of the natural cartilage. The native RH is has a complex somewhat elliptical geometry while most current prostheses are axisymmetric. The purpose of the present study was to compare axisymmetric and ‘anatomical’ RH prosthesis geometries on joint contact area and stress. Method: A finite element model was developed with a natural capitellum articulating with a concave RH hemiarthroplasty prosthesis having either an axisymmetric (spherical) or anatomical (elliptical) geometry. The axisymmetric RH was given a 20.4 mm concave radius to mimic a commercially available device. The anatomical RH was given maximum radius of 20.4 mm and a minimum radius of 15.7 mm as determined from previous anthropometric studies. Maximum stress, contact pressure (CP) and contact area (CA) were computed for a 100 N load at a variety of flexion angles and RH rotations. Results: It was apparent that the natural capitellum surface was not axisymmetric because a non-circular contact area was generated during articulation with the axisymmetric RH. For the anatomical RH, the average CA for all RH rotations was 22% larger at 0°, 11% larger at 45° flexion, but 26% smaller at 75° flexion, relative to the axisymmetric design. With the long axis of the RH oriented in the M-L direction, the anatomical model reduced the maximum cartilage stress by an average of 14% at all flexion angles. When the long axis of the RH was oriented in the A-P direction, the average CP was reduced, but the peak cartilage stress was increased. Analysis of contact morphology showed this was a result of edge loading as the small radius of the anatomic RH impinged on the capitellum, which had a larger natural curvature in the M-L direction. Conclusion: The results of the present study show that, in comparison to the axisymmetric design, an anatomical RH hemiarthroplasty can affect CA, and in some positions reduce average CP & peak cartilage stress. This effect was most pronounced when the RH long-axis was oriented in the M-L direction. While it appears that an anatomic elliptical RH may increase contact area relative to an axisymmetric spherical radial head with the elbow in some angles of flexion and the forearm in some positions of rotation, this was not a consistent finding throughout all positions analyzed. Further studies are needed to ascertain the effect of subtle changes in both shape and size of RH prostheses on the load transfer mechanics at this articulation to determine optimal implant design and in-vivo orientation. 86: Development of a materials-testing fixture to enable asymmetric loading of the lower limb: An application of in-vivo gait data Kristyn M Leitch, ON; Trevor B Birmingham, ON; Jacob M Reeves, ON; Robert J Giffin, ON; Cynthia E Dunning, ON Purpose: Experimental parameters to test material properties of fixation plates used for medial opening wedge high tibial osteotomy (HTO) are typically based on static, radiographic measures of bony alignment and rarely consider in-vivo gait data. During walking, the ground reaction force (GRF) passes medial to the stance limb, creating a frontal plane lever arm, an adduction moment, and subsequent asymmetric loading. The purpose of this study was to design and test a novel multi-axis fixture to be used in a materials testing machine to enable asymmetric loading of the lower limb in a manner more representative of human gait. Four hypotheses were tested: (1) distribution of load on the medial side would range considerably depending on experimental parameters; (2) at a representative frontal plane lever arm of 3cm, distribution of load on the medial side would be approximately 60-75%; (3) coefficients of variation (CoV) for load distribution measurements obtained within a single testing session (repeatability) would be ≤2%; and (4) CoV for measurements obtained from separate testing sessions completed within and between test days (reproducibility) would be ≤ 5%. Method: Three-dimensional kinematics and kinetics collected from 166 patients with medial compartment knee osteoarthritis before and after high tibial osteotomy were used to identify representative values for the frontal plane lever arm about the tibiofemoral joint, ground reaction force, and tibiofemoral angles. A fixture was designed and fabricated based on these data and used in a materials testing machine with a pressure measurement system to quantify the distribution of applied loads between medial and lateral contact surfaces of proximal tibia and distal femur sawbones. First, the change in distribution of medial-lateral compartment loads was evaluated using four lever arms, the corresponding angles between the tibia and GRF, and a compressive force of 900N (the approximate mean frontal plane GRF from the in vivo gait data). Then, reliability of load distribution was tested by repeating measurements using a 3cm lever arm (the mean frontal plane lever arm from the in vivo data 24 months post-surgery). Results: The change in distribution of loads using lever arms from 1 to 4 cm ranged from 5.55-to-85.06%. The load on the medial side was 70.1%, when using a representative lever arm of 3cm. Coefficients of variation for repeated measures ranged from 0.66%-to-1.83% for trials within one test session, was 2.70% for trials between test sessions within one day, and was 4.88% for trials between days. Conclusion: Results demonstrate appropriate asymmetric loading and excellent test-retest reliability. These findings suggest the fixture enables loading of the lower limb in a manner more representative of walking and will be used for future materials testing of HTO plate designs. 87: Factors affecting stability of reverse shoulder arthroplasty Ryan T Bicknell, ON; Allison L Clouthier, ON; Markus Hetzler, ON; Graham Fedorak, ON; Tim Bryant, ON; Kevin J Deluzio, ON Purpose: Despite the success of reverse shoulder arthroplasty in improving pain and function, complication rates remain high with dislocation often being the most common complication. Although some factors affecting stability of the prosthesis have been studied, the majority have not been examined in a physiological model that simulates bony geometry and active muscle loads. Therefore, the purpose of this study was to investigate the effect of arm position, loading direction, humeral socket constraint, glenosphere diameter, and glenosphere eccentricity on stability of reverse shoulder arthroplasty as well as the interactions between these factors. Method: A custom designed kinematic shoulder simulator was used to examine the force required to dislocate the prosthesis in a synthetic bone model. The three heads of the deltoid were modelled using pneumatically actuated cables and a displacing force was applied to the humeral component using a linear actuator. Several factors were investigated: arm position (abduction (45 and 60 degrees) and horizontal flexion (-15 and 55 degrees)), loading direction (anterior, posterior, superior, and inferior), humeral socket constraint (low and high), glenosphere diameter (36 and 42mm), and glenosphere eccentricity (central and inferioroffset). A randomised half-fraction factorial experiment design was used to investigate the factors and a six-way ANOVA was performed to determine significance. Results: Increasing glenohumeral abduction from 45 to 60 degrees resulted in a 30% increase in force to dislocate the shoulder and changing from a central to an inferior-offset glenosphere resulted in a 17% increase in force to dislocate (p<0.05). In addition, increasing humeral socket constraint increased stability if the shoulder was dislocated superiorly (88% increase), posteriorly (66% increase), or anteriorly (36% increase) (p<0.05), but not inferiorly (p>0.05). Flexion and glenosphere diameter did not have a significant effect on stability (p>0.05). Conclusion: It was determined that greater abduction increases stability of reverse shoulder arthroplasty. This is likely due to the greater deltoid forces required to achieve this posture, and, therefore, increasing deltoid tension may be an effective method of improving stability. Using an inferior-offset glenosphere also increases stability and increased socket constraint improved stability in all directions except inferior. The interaction between humeral socket constraint and loading direction, as well as the lack of influence of flexion and glenosphere diameter, highlights the complicated nature of the instability issue, as well as the importance of undertaking future research to understand dependencies between factors affecting stability. 88: Kinematic Comparison Between Gender Specific and Traditional Femoral Implants Carolyn Anglin, AB; Stefan Karl Saevarsson, AB; Gulshan B Sharma, AB; Spencer Montgomery, AB; Karen CT Ho, AB; Heiko Ramm, DE; Robert Lieck, DE; Stefan Zachow, DE; Carol Hutchison, AB; Jason Werle, AB Purpose: Gender-specific (GS) implants for total knee arthroplasty (TKA) have been introduced that better suit the female knee shape (Mahfouz 2007). The overall goal is to increase the success rate of TKA in females. Several recent studies compared the clinical outcomes between males and females with traditional implants, and between females with traditional and GS implants. Most of these studies did not find a significant difference between the implant designs (Song 2011, Kim 2010). However, clinical scores are unable to detect subtler differences related to patellofemoral (PF) function, which could lead to differences in patient satisfaction. The industry claims that the design differences should lead to better patellar tracking in women but, to our knowledge, no in vivo study has been performed that evaluates what effect GS knees have on PF kinematics. We have developed a unique, validated protocol that makes this possible (Sharma 2012 ORS). Method: We imaged 24 TKA subjects. Of these, 2 subjects were bilateral resulting in 15 GS implants and 11 traditional implants. Static radiographs were taken at 8 different knee flexion angles, 0°, 15°, 30°, 45°, 60°, 75°, 90° and at max flexion. Subjects put their foot on different heights of Plexiglas to weightbear at these increments. For each knee flexion angle two images were taken, with the X-ray source at 10° below horizontal and at horizontal. X-ray images from two different positions makes matching 3D implant models to the sagittal 2D images more accurate than a single X-ray image. 3D models of the implants were reverse engineered using computed tomography imaging. A calibration frame placed around the subject’s knee made it possible to calibrate the 2D images. Results: The only significant difference found when comparing the PF kinematics of GS femoral implants to traditional implants was for PF mediolateral translation at 0° knee flexion (p=0.02). All other kinematic measures showed large ranges of variability, obscuring any differences between the two groups. There were no significant differences in tibiofemoral kinematics. Conclusion: A more lateral patella at 0° knee flexion for GS implants compared to traditional correlates with the design of the GS implant which has a more lateral femoral groove in early flexion. None of the subjects who participated in the study were experiencing severe knee pain and we can therefore not conclude if one of the designs had better tracking than the other. The subjects had been operated on by two different surgeons; it could not be seen that this affected the variability within each group. Both surgeons found it easier to get the correct anteroposterior/mediolateral dimension ratio with the GS implant. This is the first time PF kinematics has been compared between these two implant designs. Additional data were collected for this study which will make it possible for us to analyze the knee kinematics in more detail and determine the effects different designs have on the patients’ quality of life. 89: Load Transfer at the Distal Ulna Following Simulated Colles’ Malalignment Masao Nishiwaki, ON; Gillian Greeley, ON; Emily Lalone, ON; Louis Ferreira, ON; James A Johnson, ON; Graham JM King, ON Purpose: Distal radial (Colles’) fractures commonly heal with varying magnitudes of malalignment which often leads to poor clinical outcomes. Abnormal patterns of loading at the distal radioulnar joint may explain stiffness, pain and arthritis that are commonly seen with healed angulated and displaced distal radial fractures. The objective of this study was to examine how varying degrees of isolated and combined distal radius deformities, with and without triangular fibrocartilage complex (TFCC) injury, affect distal ulnar loading using an in vitro model. It was hypothesized that distal radial malalignment will increase loading at the distal ulna, and that the loading would be the lowest with the radius in its native orientation. Method: A load cell capable of measuring medial-lateral, and anterior-posterior forces was developed and implanted in the distal ulna, just proximal to the native ulnar head. Active forearm rotation was achieved in 8 fresh-frozen upper extremities (Age: 71 years (49 to 84 yrs); 6 M; 4 Right) using a joint simulator. A modular implant designed to simulate dorsal angulation and dorsal translation deformities was attached to the distal radius. Active pronation and supination motions were simulated with the elbow at 90° of flexion and kinematic data was recorded using a tracking system. Colles’ type deformities of 0°, 10°, 20° l translation were simulated and evaluated both independently and in combinations. Testing was performed before and after sectioning of the TFCC. Results: For the native position, there was greater ulnar force with the forearm in supination relative to pronation (p=0.01). Sectioning the TFCC did not alter the distal ulnar load (p=0.6). As the magnitude of dorsal angulation and translation of the Colles’ deformities increased, distal ulnar force up to 165% of the native condition with the most aggressive deformity. (p=0.008 and p=0.002 respectively). Combined angulation and translation caused a greater force than either of the conditions in isolation (p=0.002). Sectioning the TFCC resulted in a reduction in ulnar force for all malalignment conditions; however, this was not significant (p=0.08). Conclusion: As hypothesized, this study showed that in a cadaver model simulating distal radial Colles’ deformities, increasing malalignment of the distal radius increased the forces measured at the distal ulna. Sectioning of the TFCC released the tethering effects of the DRUJ ligaments reducing distal ulna loads in the setting of distal radial deformities. This in vitro data demonstrates the sensitivity of distal ulnar loading to distal radial malalignment and suggests a possible mechanism to explain, in part, the development of ulnar wrist pain in patients with healed displaced distal radial fractures. 90: Patella Bone Density Is Lower In Knee Osteoarthritis Patients Experiencing Pain At Rest Wadena D Burnett, SK; Saija A Kontulainen, SK; Christine E McLennan, MA; Diane Wheaton, MA; Carl T Talmo, MA; David J Hunter, AU; David R Wilson, BC; James D Johnston, SK Purpose: Osteoarthritis (OA) of the knee is a painful, debilitating joint disease characterized by cartilage degeneration and changes in the underlying subchondral bone. OA related knee pain is difficult to treat because the pathophysiology of pain is poorly understood. Subchondral bone of the patella is innervated, and could be a source of OA-related knee pain. The objective of this study is to determine if there are measurable differences in patellar subchondral bone density between knee OA patients experiencing no knee joint pain at rest and those experiencing severe to extreme pain. Method: The preoperative knee of 42 patients (17M:25F; mean age: 64± SD10 years) was scanned using quantitative computed tomography (QCT, Mindways) prior to total knee replacement and scored for pain using Western Ontario and McMaster Universities Arthritis Index (WOMAC). Knee pain at rest was defined as moderate to severe pain (score 2-4) in bed or while sitting/lying down. Patients were subdivided into two groups according to ‘pain’ (N=21, 8M:13F) and ‘no pain’ (N=21; 9M:12F). Patella bone mineral density (BMD) was assessed using QCT topographic mapping of subchondral density (CT-TOMASD), which uses surface projections to assess cortical and trabecular subchondral BMD at specific normalized depths of 0-2.5mm, 2.5–5.0 and 5-7.5mm from the subchondral surface. Total BMD was evaluated (lateral + medial facets) as well as regional BMD in the superior, middle and inferior thirds of the lateral facet. We used independent sample t-tests (α<5%, p<0.05) to compare regional BMD between the ‘pain’ and ‘no pain’ groups using SPSS 18.0. Results: Total lateral facet density was 16% lower in OA patients with knee pain across the 5-7.5mm depth (‘pain’ 263±77 mg/cm3 K2HPO4; ‘no pain’ 316±84). Inferior density at the lateral facet was 13% lower at the 0-2.5mm depth (‘pain’ 438±94; ‘no pain’ 504±94), 26% at the 2.5-5mm depth (‘pain’ 208±75; ‘no pain’ 270±59), and 36% lower at the 5-7.5mm depth (‘pain’ 187±71; ‘no pain’ 239±66). BMD did not differ between groups at other regions. Conclusion: The CT-TOMASD imaging technique demonstrated lower regional density in OA patients with pain at rest. Differences in density at the distal site were approximately five times greater than calculated precision errors (%CV<7%). These results add to previous related findings, between pain and bone marrow lesions, which may be related to apparent BMD. The relationship between clinical pain scores and patellar BMD has not yet been explored or reported. Decreased lateral facet BMD could also be due to an interaction between adaptive bone metabolic activity and patellar joint loading patterns. Other relations to explore are patellar alignment and increased patellar-femoral involvement. The outcomes of this study provide evidence of a relationship between pain and BMD and may enhance the understanding of OA pathophysiology and provide new therapeutic targets, such as bone modifying drug treatments or focused physiotherapy and exercise. 91: Prototype Development for Treatment of Periprosthetic Fractures of the Distal Femur Aaron M Muizelaar, ON; Mitchell Winemaker, ON; Cheryl E Quenneville, ON; Gregory R Wohl, ON Purpose: Current stabilization methods for periprosthetic fractures of the distal femur have been inadequate in achieving sufficient fixation. Reported complications include nonunion (9%), fixation failure (4%), infection (3%), and revision surgery (13%). The purpose of this study was to develop and evaluate a new bilateral plating technique that would increase stabilization, facilitate bony healing, and maintain overall alignment of the prosthesis with respect to the femur. Method: Medial and lateral stainless steel locking plates were designed based on the geometry of the distal femoral condyles of a synthetic femur and a femoral prosthesis. To take advantage of the rigidity of the prosthesis as well as to maintain alignment and stabilization of the fracture, the distal end of each plate has a small tab that inserts into the slot on either side of the prosthesis used during surgical implantation. A 3mm wide transverse supracondylar fracture was created 5mm proximal to the anterior aspect of the prosthesis. A single transcortical compression bolt along with several locking screws were used to secure each plate to the femur and the prosthesis. The implanted femur was loaded in axial compression (0º flexion) at incremental loads to 600N and in posterior bending (90º flexion) incrementally to 500N. Medial and lateral unicompartmental loading was also performed in the axial orientation to simulate varus and valgus loading. Testing was repeated five times in each configuration to assess repeatability. Results: Fracture motion, calculated at each load increment using a digital microscope, was highly repeatable. Posterior loading at 500N caused shear (0.77±0.06mm in the transverse plane), axial compression (0.20±0.02mm), and rotational (17.3±1.9°) motions. Axial loading at 600N resulted in corresponding values of 0.004±0.02mm, 0.07±0.01mm, and 1.4±0.4°. Unicompartmental loading caused shear and compression displacements of 0.08mm and 0.06mm for valgus loading, and 0.05mm and 0.08mm for varus loading. Conclusion: Optimal fracture healing has been shown to occur when gap motion is within 210% of the total gap size (0.06-0.30mm for a 3mm gap). All displacement values fell below 10% except for shear motion during posterior bending. However, at a more clinically relevant rehabilitation load of 200N, an average shear of 9.7% was observed and distal rotation was reduced. No other known studies use both medial and lateral plates, or incorporate the femoral prosthesis into stabilization of the fracture. A previous study found that the fracture site experienced shear and compression displacements of 6.4mm and 3.5mm with a single lateral plate, and 1.1mm and 0.7mm when fixed with an intramedullary nail. These values suggest that the proposed bilateral plates are capable of greatly improving the stability of the fracture in comparison to current fixation techniques. 92: Rabbit Joint Capsule Cells Collagen Gel Contractile Properties: Parallels to Human Post-traumatic Contractures Kevin Hildebrand, AB; Mei Zhang, AB; Paul Salo, AB; A Dean Befus, AB; Dave Hart, AB Purpose: The joint capsule is the critical anatomic structure limiting joint motion. Previous work has suggested a myofibroblast-mast cell-neuropeptide axis of fibrosis in the pathologic capsule. Using an in vitro collagen gel contraction assay, we test the hypothesis that rabbit joint capsule cells (JC) can contract the gel, and that this is stimulated by mast cells (MC) and enhanced further with Substance P (SP). Method: Six rabbits had a standardized surgical procedure performed on the right knee to produce post-traumatic joint contractures. The rabbits were killed 8 weeks after surgery and the joint capsules were minced, placed into culture flasks and resulting cells incubated. Upon confluence, cells were trypsinized, re-suspended at selected densities, and mixed with neutralized collagen solution composed of 59% neutralized PureCol collagen. The human mast cell line, HMC-1, and the NK1 receptor antagonist RP67580 (NK1 is the SP receptor) were obtained. Aliquots (500 μl) of collagen gel with only JC (2.5 × 105), MC (7.5× 105), or JC (2.5 × 105) and MC (7.5× 105) [1:3] were then casted into wells of a 24- well culture plate. In some experiments, SP (1 x 10-6 M) +/- RP67580 (0.05 mM) were added. The gels were maintained with DMEM/F-12 plus 1% serum replacement and incubated at 37°C. The gels were detached from the wall and the bottom of culture plate wells, and photographed between 0 - 72h post- release. The areas of gel were measured using an image analyzer. Statistical analysis involved ANOVA with posthoc Tukey correction. P < 0.01 was significant. Results: Joint capsule cells contracted the collagen gels and this was enhanced in the presence of SP, although not statistically significant. Joint capsule cells combined with MC enhanced the gel contraction more than JC alone or with SP (p<0.001). The addition of SP accelerated the JC mediated gel contraction in the presence of MC the greatest (p<0.001 over all other conditions). The inhibitor RP67580 decreased the collagen gel contraction induced by JC, even when MC and SP were present in optimal numbers / concentrations. Finally, MC alone or with SP were unable to contract collagen gels. Conclusion: Rabbit JC contract collagen gels. This contraction is enhanced in the presence of human MC. It is further increased by SP and this response is specific since it is diminished by the NK1 receptor antagonist RP67580. This interaction of JC, MC and SP is complex. While not presented in this abstract, the effects are dose dependent. These findings validate the experimental technique, although the concentrations in the joint capsule in vivo are unknown. This in vitro research shows similar responses to MC and SP by JC from rabbit and human post-traumatic contractures further validating the animal model with the human condition. Given that previous in vivo research has shown the potential for a MC stabilizer approved for human use to decrease joint contractures in the rabbit model, there is support for the use of MC stabilizers in human trials. 93: The Correction of Medial Joint Loading with Valgus Unloader Brace is Related to Varus Thrust Janet Conrad, NS; Cheryl Hubley-Kozey, NS; Janie L Astephen-Wilson, NS; Michael J Dunbar, NS; William Stanish, NS Purpose: Total knee replacement surgery waitlists exceed recommended times and projected demands will not be met by orthopaedic human resources; hence the need for effective non-operative treatments of knee osteoarthritis (OA). Valgus unloader braces (VUB) are a treatment option for medial compartment knee OA. Braces are purported to apply a valgus load to the knee, reducing medial compartment loading associated with disease progression. Studies are inconclusive on the mechanism by which VUB affect joint loading, making prescription difficult. Varus thrust is an abrupt lateral motion of the knee in early stance during weight acceptance (Chang et. al, 2010) present in a number of individuals with knee OA. The aim of the present study was to determine the effect of VUB on medial compartment loads and examine the changes in frontal plane angles as a mechanism for change in loading. Method: Thirty-three individuals with moderate, medial compartment knee osteoarthritis (OA) (25 males, eight females, 57.6(8.7) years) were prescribed a VUB. 3D motion (OptoTrakTM) and ground reaction forces (AMTI) were captured during walking with and without the brace. Condition was randomly assigned. Frontal plane knee moments and angles (varus/valgus) were calculated using inverse dynamics and Euler equations (Landry et. al, 2007). Principal component analysis identified key amplitude and temporal changes of the frontal plane moment waveforms during gait (Landry et. al, 2007). Participants were grouped based on changes in frontal plane moment magnitude (a surrogate measure of medial compartment load) with brace application: i) those that increased knee loads, ii) those who did not change, and iii) those that decreased loads when the brace was applied. Varus thrust was identified as the range in frontal plane angle within the first 30% of the gait cycle. Two-Way ANOVA tested for differences among groups and the brace and no brace condition for the minimum and maximum angles in early stance, and varus thrust. Alpha was set at .1 as this was a preliminary study. Results: Three equal sized sub-groups were identified based on the change in frontal plane loading caused by brace wear. Significant condition (brace/no brace) differences were found for the minimum angle and varus thrust (p<0.1 ). Varus thrust was larger and the minimum angle was more valgus during brace condition. A significant group by condition interaction (p<0.1) was found for the maximum angle. Post-hoc testing indicated that the increase group had increased varus alignment at the end of varus thrust during the brace condition. Conclusion: This preliminary study provides novel findings that the VUB does not provide a consistent change to frontal plane mechanics of the knee. While the VUB placed the knee in more valgus initially, different responses were found when the knee was loaded during walking. These results have implications for who may or may not benefit from VUB prescription. 94: Association of Vitamin D Receptor (VDR) Gene Polymorphism and Vitamin D Status in Knee Osteoarthritis Divya Sanghi, IN; Rajeshwar Nath Srivastava, IN Purpose: Evidence suggests that low serum levels of vitamin D may increase the severity of Osteoarthritis (OA). VDR gene polymorphism is known for its association with osteoporosis. The inverse relationship between osteoporosis and OA suggests that VDR gene polymorphism is a candidate gene to be associated with OA. This study was done to analyze the association of vitamin D receptor gene polymorphism (Taq1 and Apa I) and serum vitamin D levels in knee osteoarthritis Method: This case control study consisted of 180 Osteoarthritis Knee patients and 150 controls. Cases were clinically diagnosed according to ACR criteria. Gradation of the disease was done by using KL grading system on the basis of radiological findings. The serum levels of vitamin D were assessed by using kit of Enzyme Linked Immunosorbent Assay. Detection of VDR gene polymorphisms (Taq1 and Apa I) were done by PCR-RFLP technique Results: We observed an insignificant association for genotypes of TaqI(p=0.086) and ApaI(p=0.60) polymorphism between cases and controls.However, for TaqI marginal significant association (p=0.053, OR 1.4, 95% CI 1.008-1.945) was observed between wild type(T) allele and mutant type(t) allele, but for Apa I, there was no significant difference (p=0.334, OR 1.17, CI 1.367-1.867) between wild type(A) allele and mutant type(a) allele.We observed a significant association of low level of serum vitamin D levels in homozygous mutant(tt) genotypes as compared to heterozygous(Tt) and wild type(TT) genotypes. But In case of ApaI, we found higher serum vitamin D levels in homozygous mutant(aa) genotype in comparison to heterozygous(Aa) and wild type(AA) genotype but this difference was not statistically significant Conclusion: Though insignificant association was found between osteoarthritis and the genotypes of TaqI and ApaI polymorphism, a significant association with mutant allele of TaqI(t) was observed. Additionally, the association of mutant allele with reduced level of vitamin D was noted 95: Co-Culture of Meniscus Fibrochondrocytes and Bone Marrow Mesenchymal Stromal Cells on a Collagen Scaffold for Inner Meniscus Reconstruction Adetola B Adesid, AB; Stephanie T Lim, AB; Norah-Faye Matthies, AB; Aillette Mulet-Sierra, AB; Nadr M Jomha, AB Purpose: Meniscus is a fibrocartilaginous tissue crucial for healthy knee joint biomechanics. The reparative capacity of the meniscus is limited to the outer vascularized region and injuries in the inner avascular portion do not heal often leading to early development of osteoarthritis. Cell-based tissue engineering has been advocated to formulate a living and transplantable meniscus substitute. However, this strategy requires sufficient number of cells to produce functionally competent extracellular matrix (ECM) proteins that are central to the biomechanical role of the meniscus. We have demonstrated that combining human meniscus cells (MC) and bone marrow mesenchymal stromals cells (BM-MSCs) in a biomaterial-free microenvironment results in a synergistic increase in the production of ECM characteristic of inner meniscus. With the goal to generate a cell-based meniscus substitute, we investigated the matrix-forming capacity of co-cultures of MCs and BM-MSCs on a clinically approved collagen I-based biomaterial. We hypothesized that a collagen I-based scaffold will support the formation of an inner meniscus-like tissue after co-seeding with MCs and BM-MSCs. Method: Menisci were harvested from 4 patients (mean age: 60.5) after total knee arthroplasty. MCs were obtained after menisci digestion with collagenase and plated in DMEM plus 10%FBS at 37°C under 21%O2 in a humidified incubator with 5%CO2. Bone marrow aspirates were obtained from the iliac crest of 4 patients (mean age 55.5) undergoing routine orthopaedic procedures. BM-MSCs were obtained by plastic adherence after cultivation of bone marrow mono-nucleated cells. BM-MSCs were used at passage 2. MCs and BM-MSCs were seeded simultaneously into collagen I scaffolds (DuraGen) and cultured in a serum-free medium containing TGF-beta 3. MC:BM-MSC ratio was 25:75, and the total cell number was 1 x 10E6. Scaffolds containing pure MCs or pure BM-MSCs served as experimental controls. All cell-scaffold constructs were cultured for 3 weeks under 21%O2 in a humidified incubator with 5%CO2. Constructs were analyzed for glycosaminoglycan (GAG) and DNA contents, and for cartilaginous matrix gene and protein expression. Results: Constructs from co-cultured cells demonstrated enhanced synthesis of DNA (1.53fold) and GAG-rich matrix (1.46-fold) and collagen II (2-fold) expression relative to controls. Increased collagen II deposition was confirmed histologically. Collagen I expression was the same in all constructs. There was some evidence of hypertrophic chondrogenesis of BM-MSCs in all BM-MSCs laden constructs; although, to a lesser extent in constructs derived from cocultured cells. Conclusion: Our data provides evidence that co-culture of MC and BM-MSCs on a collagen I scaffold is a feasible strategy to generate a living implant for inner meniscus reconstruction. Further investigation to mitigate hypertrophic differentiation of BM-MSCs is needed to establish phenotypic stability of the co-cultured cells. 96: Differentiation of Mesenchymal Stem Cells by Soluble Factors Mediated by Direct Co-Culture of Meniscus Cells and Mesenchymal Stem Cells Mark F Sommerfeldt, AB; Leila Laouar, AB; Aillette Sierra, AB; Nadr Jomha, AB; Adetola Adesida, AB Purpose: Normal knee function is dependent upon healthy menisci. Injury to the menisci has been shown to affect joint loading and lead to osteoarthritis. Cell-based strategies are being pursued as an option in the treatment of meniscus injury. However, culture expanded meniscus cells (MCs) lose the ability to express matrix proteins that are essential to meniscus function. Previous work has shown that co-culture of mesenchymal stem cells (MSCs) and unexpanded MCs enhances matrix production of MCs. Co-culture of MSCs with MCs, chondrocytes (Ch) or nucleus pulposus (NP) cells has been shown to induce differentiation of MSCs towards MCs, Ch and NP, respectively. In this experiment, MSCs and MCs were cocultured using direct and indirect cell to cell contact. We hypothesized that co-culture of MSCs and MCs in direct contact would potentiate the expression of soluble factors that are capable of inducing chondrogenic differentiation of MSCs. Method: With ethics committee approval, bone marrow aspirates were obtained from iliac crests of three donors undergoing orthopaedic procedures. MSCs were isolated and expanded under 3% oxygen tension in α-MEM plus 10% FBS and basic fibroblast growth factor (5ng/mL) until passage two. Menisci were obtained from three patients undergoing total knee arthroplasty. MCs were isolated after menisci digestion with collagenase II (0.15% w/v) at 37˚C for 22 hours in DMEM plus 5% FBS and plated in DMEM plus 10% FBS for 24-48 hours. MSCs and MCs were co-cultured in two different configurations. In Group One, MSCs were separated from pure MCs by a 0.4 micrometre porous membrane. Using a similar membrane, Group Two MSCs were separated from a direct co-culture of MCs and MSCs (1:3 ratio). Two control groups consisted of 1)MSCs separated from MSCs and 2)MCs separated from MCs. After 10 days of culture, RNA was isolated and quantitative real-time PCR was used to assess the gene expression profile of matrix genes: collagens I-III, aggrecan, biglycan, fibromodulin and SOX-9 and a reference gene [human RNA polymerase II (RPII)]. Gene expression was then normalized to RPII and compared. Results: Group Two MSCs demonstrated a stastically significant up-regulation of aggrecan gene expression compared to Group One MSCs (p<0.05). There was significant (p<0.05) upregulation of collagen IIB, IIA, and SOX-9 gene expression in Group One MCs (MCs separated from MSCs) compared to the MC control group. Conclusion: Co-culture of MSCs and MCs in direct contact may increase the expression of soluble factors that are capable of inducing chondrogenic differentiation of MSCs. Secondarily, co-culture of MCs and MSCs separated by a porous membrane may be a means of maintaining MC phenotype as evidenced by increased expression of collagen producing genes by MCs. Expression of soluble factors from each group of cells is the likely explanation by which these interactions occur. Identification and use of these factors could enhance cellbased strategies aimed at meniscus repair and regeneration. 97: Increased Subchondral Bone Density Associated with Hip Impingement Andrew D Speirs, ON; Paul E Beaulé, ON; Kawan Rakhra, ON; Hanspeter Frei, ON Purpose: To examine acetabular subchondral bone density differences between subjects with symptomatic and asymptomatic cam-type femoro-acetabular impingement deformities, and normal asymptomatic controls. Method: Patients undergoing surgery for correction of cam-type hip impingement deformities were recruited (‘Surgical’ group) as well as asymptomatic volunteers; asymptomatic subjects were classified has having a deformity (‘Asymptomatic’) or no deformity (‘Control’) based on the alpha angle. Five subjects in each group underwent quantitative CT scans, including a calibration phantom, of the pelvis from the iliac crest to lesser trochanter. Both acetabuli were segmented for each patient. The surface model of each acetabulum was then divided into 12 wedge-shaped regions of bone, 10mm deep, and a tetrahedral mesh was generated for each wedge. Image intensity was sampled in each tetrahedron using Amira (v5.3) software and converted to bone mineral density (BMD) according to the phantom manufacturer’s guidelines. The average BMD was calculated for each wedge as the volume-weighted density average of all elements in each wedge. Differences between study groups were then analyzed using ANOVA using BMD in the centre of lumbar vertebra L5 as a covariate to account for general inter-patient BMD differences. Results: In the superior i.e. load bearing region, average BMD ranged from 404 to 463 mg/cc in the symptomatic hip of the surgical group; 435 to 481 mg/cc on side with deformity in the asymptomatic group and 372 to 408 mg/cc in the control group. In the antero-superior region, where impingement is most likely to occur, the surgical and asymptomatic groups had BMD of 460 mg/cc and 481 mg/cc, compared to 407 mg/cc in controls. The surgical and asymptomatic groups had higher BMD in all superior regions compared to the controls in both hips (p<0.05). Conclusion: Subjects with cam deformities showed higher acetabular subchondral BMD even in asymptomatic hips. This sclerosis is likely a remodelling response to the stress concentration caused by the deformity. Increased subchondral bone density results in increased bone stiffness and may influence cartilage stresses. As many as 80% of patients with cam deformities have bilateral deformities, although only 26% report bilateral symptoms. Furthermore, this study found asymptomatic subjects with cam deformities had higher BMD compared to controls, suggesting that subchondral sclerosis may play an important early role in osteoarthritic degeneration. Understanding this role could help elucidate degenerative pathways and help identify which deformities will lead to symptomatic degeneration. 98: Is Radiology a True Predictor of Clinical Severity in Knee Osteoarthritis? Divya Sanghi, IN; Rajeshwar Nath Srivastava, IN Purpose: Although discordance exists between clinical and radiographic profiles, it remains a convention to diagnosis knee osteoarthritis (KOA) by ACR guidelines and its severity by KL grades. This customary approach is in continuum because nothing better could be evolved. This study was undertaken to resolve a much debated issue as to why clinical features do not correlate significantly with radiological KOA. Method: We postulated that there might be a particular reason for wide variation in the degree to which clinical symptoms relate radiographic KOA and vice versa. The discordance noted by many authors is primarily due to the limitations of outcome measures in their radiographic study. We extended the radiological features beyond those included in KL Grades and analyzed them with clinical symptoms. 180 cases of primary KOA were profiled for demographic, clinical and radiological features. All the radiographs were evaluated for individual radiological features (IRF) on index knees by an Orthopedic Radiologist. Clinical scores were separately correlated with IRF to look for an association Results: Pain & functional disability were significant with increasing KL Grades (p=0.03, p=0.02) whereas stiffness was not. On analysis of individual radiological features, WOMACpain was significant with subchondral sclerosis (p=0.04), joint space width (p= 0.02) and tibiofemoral alignment (p=0.02). VAS-pain was significant with later two and articular incongruity (p=0.00). Functional disability was associated with medial joint space narrowing (p=0.02), tibiofemoral alignment (p=0.03), loose bodies (p=0.04) and juxtra articular osteopenia (p=0.01). However in linear regression model pain and stiffness was significantly associated with articular incongruity (p=0.00, p=0.01) and functional disability (p=0.04) and clinical severity assessed by total WOMAC scores with juxta articular osteopenia (p=0.03). Conclusion: Articular incongruity emerged a truer representative of pain and stiffness whereas Juxta articular osteopenia strongly correlated with physical disability and clinical severity in knee osteoarthritis. This study has essentially analyzed many more of the radiological features than in many previous studies and this may have contributed to the increased association between clinical and radiographic features 99: MR Imaging can Quantify Large Areas of Ablation Generated with a Novel Bipolar Cooled Radiofrequency (BCRF) Probe in a Preclinical Bone Metastatic Model Padina Pezeshki, ON; Margarete Akens, ON; Jason Woo, ON; Emily Won, ON; Cari M Whyne, ON; Albert Yee, ON Purpose: Radiofrequency ablation (RFA) is currently being used in the treatment of skeletal metastases. RFA works by locally inducing ionic heating to ablate tissue, however it has been limited by small ablative zones and incomplete tumour kill. A recent RF development utilizes a cooling system together with bipolar circuitry to create a novel probe optimized for bone treatment. This new bipolar cooled RF (BCRF) is designed to enable a larger zone of ablation and a more effective heating pattern within the bone structure. The objective of this study was to quantify performance of the BCRF probe in ablating large tumours within rabbit femora and to determine an optimum MR imaging protocol for evaluating the region of effect of the novel RFA probe. Method: Twelve New Zealand White rabbits received a 200 µl injection of VX2 suspended tumour cells into one femur. On day 14 post injection, MR images were acquired of 12 tumour bearing femurs and 12 healthy contralateral limbs, following BCRF or a sham treatment (no RF delivery). Post treatment MR imaging was repeated on day 28, followed by euthanasia and dissection. MR imaging was performed on a 3.0T GE scanner using a 5" surface coil. Images were acquired using standard 3D-SPGR and 3D-FIESTA sequences with a typical FOV of 16x16 cm (matrix = 256x256), slice thickness of 3mm, TR/TE 8.3/3.1 ms and flip angle of 55 for the FIESTA sequences and (matrix = 512x512), slice thickness of 3mm, TR/TE 4.4/1.6 ms and flip angle of 30 for the SPGR sequences. Gd-DTPA contrast agent (0.1mmol/kg) was injected in the rabbits and post contrast images were acquired. These images were used to determine the tumor and ablation volume (Amira 5.2, Visage Imaging). Results: The ablation volume was measured for each of healthy and tumour-bearing treated femurs using both FIESTA and SPGR sequences, with and without contrast agent. The overall average for ablation size was 5285±1514 mm3. It was observed that while all sequences were comparable, gadolinium enhanced images of both sequences were best in determining the region of effect of BCRF treatment with a high correlation of 99% (p=0.00) between the two sequences in tumour treated regions and 94% (p=0.005) in healthy treated regions. The untreated sham tumor samples demonstrated a rapid growth of tumor in the bone (i.e. volume more than doubled). In general, detection of regions of interest using SPGR sequences was found to be easier as it was possible to capture higher resolution SPGR images than the FIESTA images in the same amount of time. Conclusion: This study verified the large region of effect created by the BCRF probe. As such this novel device may offer a solution for the common shortcoming of RFA devices that generate small regions of ablation. Additionally it demonstrated the utility of contrast-enhanced MR imaging when determining the ablation effect in clinical situations. 100: Intronic Single Nucleotide Polymorphism (SNP) of CALM-1 Gene is Significantly Associated with Osteoarthritis Knee: A Case Control Study Divya Sanghi, IN; Rajeshwar Nath Srivastava, IN; Sachin Avasthi, IN Purpose: Though the pathology of osteoarthritis is well defined, the etiological factors are not fully characterized. Genetic exploration of genome has resulted in several susceptibility loci isolation confirming the genetic association of disease. The Japanese population has shown higher incidence of osteoarthritis in patients having intronic and core promoter SNP in CALM-1 gene. At the same, Caucasian and Greek population showed absence of any such predisposition in their population with the CALM-1 gene SNP.The objective of the study was to determine the association of CALM1 gene polymorphism with knee osteoarthritis Method: We planned a case control study in patients of primary osteoarthritis knee with aims being to study the presence of CALM-1 gene SNP, correlation of its presence with osteoarthritis and its correlation with clinico-radiological stage of the disease. 120 cases and 120 controls were enrolled. Clinicoradiological features were noted and symptomatic clinical scoring was done. Genetic polymorphism in relation to intronic region of Calm-1 gene was studied by DNA extraction, PCR and RFLP method. Statistical analysis was done using Stata software Results: 39 (32.50%) cases and 18 (15%) controls showed the presence of SNP which was significant ( P value = 0.0022). Among SNP positive cases and controls, 5 (8.7%) cases and none controls were heterozygosis for the occurrence of SNP. On regression of affecting variables against SNP, taking the presence of osteoarthritis as dependent variable, we calculated the adjusted odds ratio of all the significant variables. Thereafter, on logistic regression to see the effect of variables on the occurrence of disease, we found age, sex, and presence of SNP affecting the occurrence of disease significantly ( p value < .05). Conclusion: CALM-1 gene intronic SNP (rs3213718) is present in Indian Population. The target SNP is significantly affecting the disease as the difference between cases and controls is highly significant (p value = .0022). Females are more predisposed for OA. Mean age of presentation in cases was 53.31+/-9.5 years. Age is a significant factor in causation of disease. However it is not influenced by existence of SNP. Between cases and controls, height, weight and BMI did not show any significant difference 101: A Clinical Evaluation of a CT-based Patient Specific Femoral Alignment Guide for Hip Resurfacing Arthroplasty Michael Olsen, ON; Douglas Naudie, ON; Abigail Thompson, ON; Jane Morton, ON; Richard McCalden, ON; Emil H Schemitsch, ON Purpose: Alignment of the initial femoral guidewire is critical in avoiding technical errors that may increase the risk of failure of the femoral component. A novel alternative to conventional instrumentation for femoral guidewire insertion is a computed tomography (CT) based alignment guide. The aim of this study was to assess the accuracy of coronal femoral component alignment using a CT-based, patient specific femoral alignment guide. Method: Between March 2010 and January 2011, 25 hip resurfacings utilizing a CT-based femoral alignment guide were performed by three surgeons experienced in hip resurfacing. Pre-operative radiographic templating was performed to assess the native femoral neck-shaft angle (NSA) and the planned coronal stem-shaft angle (SSA). Pre-operative templating data was used to plan individual femoral alignment guides. Minimum 6 week post-operative digital radiographs were used to assess the stem-shaft angle of the implanted femoral components. Results: Pre-operative templating determined a mean NSA of 134.5 degrees (SD 5.4, range 124-142 degrees). The planned SSA was a relative valgus alignment of 7.0 degrees (SD 5.7, range -6-14 degrees). A segmentation error occurred in the manufacturing of one of the jigs which did not fit the femoral head of the patient intra-operatively. Imageless computer navigation was used instead to implant the initial guidewire and this patient was excluded from further analysis. The post-operative SSA differed from the planned SSA by a mean of 1.3 degrees (SD 4.8, range -9-14 degrees). There was no significant difference between surgeons in post-operative SSA accuracy (p=0.697). The final SSA measured within ±5 degrees of the planned SSA in 20 of 24 cases (83%). There was one complication of a deep venous thrombosis in the series. Conclusion: CT-based, patient specific guidewire alignment jigs provided a satisfactory level of accuracy for coronal alignment of the femoral component with no difference in accuracy attained between users. Accuracy results of the device approach those previously established for imageless computer navigation in hip resurfacing arthroplasty. 102: An analysis of the Hip Resurfacing failures - Canadian Experience James N Powell, AB; Canadian Orthopaedic Arthroplasty Society (COAS), ON Purpose: A series of 2773 hips demonstrated a KM five year overall survivorship of 96.3%. An analysis of the revisions was undertaken to assess the factors associated with failure, and to determine whether altered patient selection, surgical implant choice or surgical technique can lead to improved outcomes. Method: A series of 2773 (2452 patients) hip resurfacings from 11 Canadian centers during the period January 2001 to December 31, 2008 were reviewed. Each center was required to have performed 50 resurfacing cases for inclusion into the analysis. Data points collected included patient demographics, diagnosis, prior operations, implant used, component size and reason for revision, as well as intra-operative and post-operative complications. Radiographic analysis was performed using DICOMeasure software ( View Tec, MXD Ltd. UK.) Results: 94 failures were assessed. The major cause of revision was femoral neck fracture 25. Other causes of failure included: femoral component loosening 17, acetabular loosening 14, Infection 13, undiagnosed pain 10, AVN five, hip impingement four, four patients had a revision for a pseudotumor. One patient had high metal ion levels necessitating revision and one patient was revised for poor function. Conclusion: The reasons for failure in our series are consistent with other published reports. Femoral neck fracture is one of the major causes for resurfacings to fail. Proper patient selection and surgical technique are important to prevent this. The rate of pseudotumors in our series is less than reported in other studies. Hip resurfacing failures may be reduced by resurfacing male paitents with a larger head diameter and by using resurfacing systems with a higher survivorship. 103: Clinical Results of a Hybrid Metal-on-Metal Resurfacing Prosthesis: An Independent Series. Paul E Beaulé, ON; Alejandro Zylberberg, ON; Toru Nishiwaki, ON; Paul R Kim, ON Purpose: As we enter the second decade of hip resurfacing for the treatment of hip arthritis, data from independent centers becomes critical to assess its overall efficiency and safety. The purpose of this study is to present the short to mid-term results of a single center’s experience with a metal-on-metal hip resurfacing device. Method: From 2001 to 2009, 548 hip resurfacings were performed using the Conserve Plus prosthesis in 460 patients (351 males) with a mean age of 48.3 years (18 to 66). Degenerative osteoarthritis was diagnosis in 505 hips. At the 6 week follow-up, stem and cup alignment was assessed using standard radiographs. Results: Mean follow-up was of 4.2 years (range, 2 to 8.1). No patients were lost to follow-up. Twenty-one (3.9%) patients required conversion to THR: acetabular loosening (9), neck fracture (4), unexplained pain (3), femoral loosening (2), adverse tissue reaction (2) and 1 infection. 5 patients had isolated acetabular component revision and maintained as a resurfacing. At the minimum two-year follow-up, the presence of a vertical cup at 6-weeks was associated with radiolucencies at final follow-up (χ2=17.00, p<.001). Five-year implant survival was 95% (95% CI: 93% to 96%). Conclusion: We continue to use the prosthesis in young active patients with good bone mass. However, acetabular component fixation remains a concern and may be related to the cobalt chrome interface. 104: Does Etiology Affect the Course of Femoral Head Osteonecrosis? Mansour Abolghasemian, IR; Mehdi Ramezan Ramezan Shirazi, IR; Oleg Safir, ON; Mohammad Ghazavi, IR Purpose: Osteonecrosis of the femoral head (ONFH) is one of the leading causes of hip degeneration in the young in Iran. Although it may happen without any obvious causes, some etiologic factors have been linked to the disease. The natural history of the disease is still unclear and the time to collapse of the femoral head varies in different cases. The impact of each associated risk factor on the natural course of the disease has not been clearly determined in the literature. However, recently, a steroid-containing opioid drug called Temgesic has been being widely abused by drug addicts in Iran, resulting in increased incidence of ONFH. The purpose of this study was to assess the effect of different etiologies, including this new drug, on the course of ONFH. Since any joint preserving treatment should ideally be performed before collapse happens, it is important to estimate the interval between pain onset and head collapse in cases of ONFH. Method: We retrospectively assessed all patients presenting with untreated ONFH due to one of the following four etiologies; Steroid-induced (St), Temgesic-induced (Te), trauma-induced (Tr) and Idiopathic (Id). Cases showing multiple risk factors were excluded. Only those cases with sequential X-rays in whom the time of radiographic collapse was clear with maximal three months accuracy were included. These four groups were compared regarding the average time interval from pain onset to femoral head collapse, using ANOVA test. Results: Of 149 patients with ONFH, 93 (150 hips) were eligible for the study. The average age of the patients was 33.9 years and 82 patients were male. The etiology was found to be steroid use in 70, Temgesic abuse in 43, trauma in 15 and idiopathic in 22 hips. Rate of bilateral involvement was 70, 79, 0 and 64% for St, Te, Tr and Id groups, respectively.The average time to radiologic collapse and osteoarthritis was 11.2 (±6.8) months for St group, 9.1 (±4.6) for Te group, 18.8 (±7.3) for Tr group and 21.9 (±14) for Id group, respectively. Statistical analysis showed that there was no significant difference between St and Te groups, or between Tr and Id groups (P value>0.7), but time to collapse was significantly shorter for St and Te groups comparing to Tr and Id groups (P value<0.02). Conclusion: Previous studies have failed to indicate a marked difference among etiologic groups in collapse rate and some evidence exists indicating that without treatment, probably all symptomatic ONFH cases ultimately collapse, but the average time of the collapse after pain onset has not been known yet. The present study was performed retrospectively on symptomatic cases that had already collapsed to assess this unknown parameter for different etiologies. The temporal course of ONFH in Temgesic-induced cases was very close to those due to steroids, showing that the main cause of ONFH for them is probably the steroid ingredient. Importantly, it also showed that when symptomatic, a steroid-induced ONFH probably runs a much faster course to collapse than trauma-induced or idiopathic ONFH. Therefore, to be effective, any joint preserving treatment should be performed very early after pain onset in hip osteonecrosis due to steroid use. 105: Assessment of Post-Impaction Acetabular Bone Gaps in Hip Resurfacing Arthroplasty Michael Olsen, ON; Bruno Gomes, ON; Michael Donnelly, ON; Ashesh Kumar, ON; Zachary A Morison, ON; Emil H Schemitsch, ON Purpose: Press-fit acetabular component seating in hip resurfacing can be challenging as a strong interference fit is desired. Currently, a 2 mm under-ream of the acetabulum is recommended to ensure adequate fixation. There are reports in the literature that suggest a high prevalence of incomplete component seating utilizing press-fit acetabular components. It has not been established whether a reduction in the under-ream of the acetabulum results in reduced incomplete component seating and whether this leads to increased acetabular loosening due to the reduction in theoretical interference fit. The aim of this investigation was to assess the prevalence and natural history of post-operative interference gaps in hip resurfacing and determine whether reduction of the acetabular under-ream from 2 mm to 1 mm reduces the incidence of peri-acetabular radiolucencies. Method: Between February 2005 and April 2010, 327 consecutive hip resurfacings were performed by a single surgeon. Three observers assessed the frequency of peri-acetabular interference gap radiolucencies using anteroposterior radiographs in 306 hips with a minimum 1 year radiographic follow-up. An interference gap was defined as a >50% longitudinal gap in at least one of three zones of the acetabulum. Identified gaps were monitored for gap healing at latest follow-up. The standard technique of preparing the acetabulum with a 2 mm underream was modified to a 1 mm under-ream in May 2008 and a comparison was made between the proportion of gaps identified between the two methods of acetabulum preparation. Results: Half of the post-operative radiographs (51%) demonstrated the presence of a periacetabular radiolucency. The maximal gap occurred in zone 2 in 151 cases (97%) and zone 1 the remaining four cases (3%). There were no gaps greater than 4 mm detected and 76% (118/155) of gaps were ≤1 mm. At a mean follow-up of 2.7 years (range 1-6), 96% (149/155) of radiolucent gaps had healed. Four of the six gaps demonstrating incomplete healing had less than 2 years follow-up. The generalized kappa statistic indicated substantial agreement between observers for gap presence and healing, κ=0.65 and κ=0.62, respectively. There was a significant reduction in the number of interference gaps identified between acetabula prepared with a 2 mm under-ream (92/145, 63%) and those with a 1 mm under-ream (63/161, 39%, p<0.001). There were 7 revisions in the series; there were no revisions due to acetabular failure. Conclusion: Peri-acetabular radiolucent gaps were common in this series; however, they were not associated with acetabular component failure and have demonstrated a very high rate of healing. Reducing the under-ream for acetabular preparation from 2 mm to 1 mm did not result in any adverse sequelae and significantly reduced the incidence of peri-acetabular lucencies. Aggressive acetabular component seating is unnecessary and the use of a 1 mm under-ream is sufficient for adequate press-fit fixation of the acetabular cup in hip resurfacing. 106: Early Failure Rate Of Hip Resurfacing Arthroplasty With The ASR Implant Stephen M Mann, ON; John F Rudan, ON; Graham Fedorak, ON Purpose: To retrospectively review the failure rate of a consecutive series of ASR hip resurfacing arthroplasties carried out at one institution over six years. Method: One hundred thirty implants in 117 patients were reviewed radiographically, and acetabular inclination was recorded from the first post-operative image and at subsequent follow-up visits. Age, sex, femoral head component size, acetabular component generation, the use of computer navigation, and cobalt and chromium ion levels were obtained from the digital chart. Results: Twenty-one patients (16%) had ion levels above threshold values, and five of 130 implants (3.8%) required revision for loosening. Aseptic failure was associated with increased ion levels, but there was no statistically significant relationship with any of the other recorded variables. Conclusion: Increased blood levels of cobalt and chromium are common following metal-onmetal hip resurfacing arthroplasty, but do not reliably predict which patients will require revision. The other variables examined in this study do not correlate with rates of aseptic failure, which were similar to previously published values. Further research is necessary to elucidate the relationship between metal ion levels and aseptic failure, and the clinical significance of increased cobalt and chromium. 107: Long-term Graft Survival and Functional Outcome Following Free Vascularized Fibular Transfer for Pre-collapse Osteonecrosis of the Femoral Head William Eward, ON; Marc Richard, NC; Craig Rineer, NC; James Urbaniak, NC; David Ruch, NC Purpose: Osteonecrosis of the femoral head (ONFH) is a potentially debilitating condition affecting primarily young patients. Disability and dysfunction progress following femoral head collapse and degenerative hip arthrosis. Free vascularized fibular grafting (FVFG) has proven a durable means of biological femoral head preservation. When employed in the precollapse stages of ONFH, this treatment has great potential to alter the course of disease yet the long term natural history and functional outcomes in this subset of patients is not well described. Method: 61 patients (65 hips) who underwent free vascularized fibular grafting for precollapse (Ficat Stages 1-3) ONFH were retrospectively reviewed. Mean follow up time was 14.4 years (range 10.5-26.1 years). Graft survivorship, SF-12 MCS, SF-12 PCS, and Harris Hip Score were calculated. Data about activity level and narcotic pain medication usage were collected. Logistic regression of demographic and etiologic features was performed. Results: 26 of 65 hips (40%) were converted to THA at a mean 8.3 years postoperatively, leaving 39 of 65 hips (60%) with surviving FVFG at final follow up. Patients with idiopathic ONFH were more likely to elect conversion to THA, especially at time points greater than 10 years postoperatively. 64% of patients with surviving FVFG participated in active events or impact sports, compared with 38.4% of patients converted to THA. Although final Harris Hip and SF-12 PCS scores were similar between groups, SF-12 MCS scores were significantly higher (53.9 vs 49.7) in patients with surviving FVFG. 19.2% of patients who converted to THA and 7.6% of patients with surviving FVFG were using narcotic pain medication at final follow up. Demographic factors, additional procedures, and low preoperative function were not associated with changes in graft survivorship. Conclusion: Patients with precollapse, predegenerative ONFH who undergo FVFG have a durable preservation of the femoral head which either prevents or significantly delays the need for endoprosthetic hip reconstruction. In patients with successful long-term femoral head preservation, Harris Hip Scores are equivalent to patients converted to THA while activity levels and mental health scores are higher. 108: Lower-extremity Gait Mechanics of FAI Patients Do Not Return to Normal Following Corrective Surgery Mario Lamontagne, ON; Nicholas Brisson, ON; Matthew J Kennedy, ON; Paul E Beaulé, ON Purpose: The purpose of this study was to determine the effects of cam FAI corrective surgery on the biomechanics of the affected hip during level gait by comparing the hip threedimensional angular displacements, moments and powers of preoperative and postoperative FAI groups with those of a healthy control group. Method: Ten patients with unilateral symptomatic cam FAI, who underwent corrective surgery using an open or combined technique, were compared preoperatively and postoperatively, and with thirteen control subjects matched for age, sex and body mass index. Postoperative testing occurred between eight and 32 months after surgery. Three-dimensional kinematics were collected at 200 Hz using a nine-camera high-speed motion analysis system with 45 retroreflective markers affixed onto various anatomical landmarks, according to a modified Helen Hayes marker-set. Ground reaction forces were recorded at 1,000 Hz during the stance phase of the gait cycle using a force platform.Participants performed five successful barefoot walking trials at a natural, self-selected pace, where the foot of the affected leg landed on the force platform. The extracted variables of interest were the peak angles and ROM of the hip in all three planes of motion during the gait cycle, as well as the peak hip moments in all three planes of motion and the peak hip powers during the stance phase of the gait cycle. Multivariate analyses of variance were performed to detect significant differences between the groups. Using Bonferroni corrections, the alpha values used to determine statistical significance were adjusted to α = 0.017 and α = 0.025 for all kinematic and kinetic variables, respectively. Results: Results demonstrated that both preoperative (p = 0.016) and postoperative (p = 0.016) FAI groups had reduced hip frontal plane ROM compared to the control group. The postoperative FAI group also displayed reduced hip sagittal plane ROM compared to the control group (p = 0.013). Likewise, the postoperative FAI group produced smaller peak hip abduction (p = 0.013) and external rotation (p < 0.001) moments, and generated less peak hip power (p = 0.004) compared to the control group. Conclusion: The present study demonstrated that the affected hip biomechanics of cam FAI patients during level walking do not return to normal following surgery. Preoperative hip impairments, perhaps due to adopted modified gait patterns to reduce hip muscle contractions, loading and pain, resulting in muscular disuse and atrophy, persisted postoperatively. Additional impairments observed postoperatively may have resulted from the lack of complete restoration of hip muscle function following surgical incision. FAI seems to be associated with aberrant hip joint functions that have not yet been well identified. Further research, particularly with use of electromyography, is required to confirm the reasons for which the hip biomechanics of FAI patients during gait do not return to normal following surgery. 109: Outcomes of Joint Preservation Surgery: Comparison of Patients with Dynamic Dysplasia of the Hip (DDH) and Femoroacetabular Impingement (FAI) Paul E Beaulé, ON; Gillian Parker, ON; Kyle A Kemp, ON Purpose: Both hip dysplasia (DDH) and FAI are recognized as a cause of hip pain and arthritis in the young patient. Having said that, dysplasia is usually corrected with an extra-articular corrective peri-acetabular osteotomy (PAO) whereas FAI requires intra-articular bony correction. The purpose of this study was to compare the clinical outcomes of these two joint preserving surgeries to determine if their clinical outcome is comparable. Method: Thirty-six patients with DDH and 96 FAI were matched via a propensity analysis, based on age, gender, and BMI giving 26 patients (10 males, 16 females); mean age and BMI were 33.1(15-53), and 24.8 (17.3-40.0), respectively. At the time of surgery, mean Tonnis grades were 0.4 (range: 0-2) for DDH versus 1.0±0.8 (0-2) for the FAI (p=0.03). Clinical Outcome scores used were the WOMAC, SF-12, modified Harris Hip Score (HHS), UCLA Activity Score. Results: At baseline, there were no differences in outcome scores. At mean follow-up of 31mos (11-64), compared with FAI patients, those in the DDH group reported better WOMAC stiffness (27.8±22.1 vs. 43.4±19.8, p=0.03), and SF-12 physical component (48.7±9.5 vs. 42.0±9.3, p=0.04) scores. In the DDH group, no significant correlations were observed between Tonnis scores and outcome scores. In the FAI group, a moderate correlation (r=0.50) was observed between Tonnis Score and baseline HHS. Conclusion: In this propensity analysis, patients with FAI presented with a more advanced disease than the DDH. As a whole, patients with DDH did better clinically than the FAI patients which could be due the less advanced disease at the time of surgery or the fact that the surgery in DDH is extra-articular. 110: Radiographic Evidence of Pincer-Type Femoroacetabular Impingement in Patients with End Stage Hip Osteoarthritis Paul RT Kuzyk, ON; Michael Edward Sellan, ON; Zachary A Morison, ON; James P Waddell, ON; Emil H Schemitsch, ON Purpose: In pincer-type femoroacetabular impingement (FAI), the acetabular labrum is more susceptible to degenerative wear as a result of an exaggerated acetabular rim often presenting in patients with acetabular retroversion or general overcoverage of the femoral head. Radiographic measurements and markers suggestive of pincer-type impingement include the lateral centre-edge angle (LCEA) of Wiberg, tonnis angle, posterior wall sign (PWS), crossover sign (COS) and the prominence of the ishial spine (PRISS). Our study aims to determine if patients with end-stage hip osteoarthritis (OA) have a higher incidence of radiographic markers of pincer-type FAI as compared to control patients. Method: The anteroposterior (AP) pelvis and lateral hip radiographs of 244 patients (261 hips) who presented to our institution for hip arthroplasty or hip fracture fixation between 2006 and 2008 were retrospectively reviewed. Six cohorts were compared: Male (n=51) and female (n=25) patients with end stage hip OA < 55 years old; Male (n=34) and female (n=50) patients with hip OA ≥ 55 years old; Male (n=34) and female (n=65) hip fracture patients ≥ 65 years old without radiographic evidence of hip arthritis used as controls. PWS, COS, PRISS, LCEA and Tonnis angles were measured by three coauthors on AP pelvis radiographs for each cohort. A one-way ANOVA with Tukey’s test was used to compare the LCEA and Tonnis angles for the six cohorts. A Pearson chi-square test was used to compare the incidence of PWS, COS and PRISS in the six study groups. Results: Older female hip arthroplasty patients had significantly more patients with LCEA values > 39°, indicative of pincer-type FAI, than any of the other 5 cohorts (36%; p<0.05). Conversely, 32% of younger female arthroplasty patients displayed evidence of hip dysplasia, defined as an LCEA < 20°, a trend which was not observed in patients from the other cohorts (p<0.05). The younger female arthroplasty cohort also had the largest proportion of patients with Tonnis angles > 10°, consistent with instability of the hip (p<0.001). Young males with end-stage hip OA had significantly more patients with PRISS than any of the other 5 cohorts (p<0.01). This trend was maintained for both affected and contralateral hips. The frequency of acetabular retroversion, as noted by the presence of PWS, COS and PRISS, was highest in male patients, independent of age or diagnosis (p<0.001). Conclusion: Acetabular overcoverage contributing to pincer-type FAI was most pronounced in older female arthroplasty patients. Hip dysplasia and instability was most evident in younger females with end-stage hip OA. Younger male patients presenting for hip arthroplasty displayed the highest frequency of markers of acetabular retroversion. Our study demonstrates that patients with end-stage hip OA commonly display evidence of pincer-type FAI. 111: Clinical, Radiographic and Metal Ion Comparison of 36mm, 40mm and 44mm Metalon-Metal Total Hip Arthroplasty Nayla G Papadopoulos, QC; Gregory Manoudis, QC; Sarantis Abatzoglou, QC; Laura Epure, QC; Olga Huk, QC; David Zukor, QC; John Antoniou, QC Purpose: Cobalt-Chromium alloy for metal-on-metal (MM) hip prostheses have superior wear resistance compared to the conventional polyethylene-on-metal prostheses, making it a more suitable alternative for younger patients. The potential carcinogenic effect of metal ions, mainly Cobalt (Co) and Chromium (Cr), found in the blood of patients with MM hip prostheses is a serious cause of concern. Tissue damage can be induced by oxidative stress. Total antioxidant status (TAS), total peroxides (TP), and nitrotyrosine (NT) are all oxidative stress markers (OSM) thought to be affected by Cr and Co levels. As larger head bearings encourage fluid film lubrication and consequently decrease wear, we hypothesize that metal ion levels as well as oxidative stress markers may correlate with greater wear rates, smaller head bearings and increased physical activity. Method: We followed 90 patients undergoing total hip arthroplasty (THA) with different head sizes of Cobalt-Chromium-Molybdenum (Mo) prostheses (34 patients for 36mm group, 42 patients for the 40mm group and 14 patients for the 44mm group). Patients’ follow-up occurred at year 0.16, 0.33, 1 and 2. Patients with bilateral hip involvement, concurrent metal hardware, multiple co-morbidities, inflammatory joint disease or infection were excluded from this study. Whole blood samples collected at each follow-up visits were analysed by inductively coupled plasma-mass spectrometry (ICP-MS) to determine the levels of Co, Cr and Mo. Serum nitrotyrosine levels were quantified using Nitrotyrosine-EIA essay whereas total peroxide concentration were measured with Biomedica OxyStat assay and TAS with the Oxford Biomedical total anti-oxidant power kit. Radiographic analysis was performed using Einzel-BildRoentgen-Analyse (EBRA) cup software. During each visit, patients’ clinical outcomes were recorded with calculation of Harris Hip Scores (HHS) and University of California Los Angeles Activity Scores (UCLA). Results: Using Mann-Whitney U test, preliminary results failed to show statistical difference in metal ions concentration between each of our study group at any given follow-up time. For the HHS correlation, we found a Spearman’s Rho of 0.20 (P=0.0009) for Co, 0.19 (P=0.0018) for Cr and – 0.08 (P=0.2293) for Mo. For the UCLA correlation, a Spearman’s Rho of 0.27 (P=0.0001) was found for Co, 0.23 (P=<0.001) for Cr and -0.06 (P=0.3637) for Mo. Plasma markers for oxidative stress also show no statistical correlation with metal ion concentration. For the 36mm, 40mm and 44mm groups, the mean cup inclination angle was of 41°, 43° and 40° respectively. Conclusion: Our results show no correlation between prosthetic head size and concentration of metal ions released in the blood as well as between oxidative stress markers and metal ion levels. No strong correlation was shown to be present between the metal ions concentration and either the Harris Hip Scores or UCLA Activity Scores. 112: Delta Ceramic on Ceramic THA- Midterm Results including Squeaking and Liner Fracture Rates James P McAuley, ON; William Hamilton, US; Jeff Murphy, US; Thomas Blumenfeld, US; Douglas Dennis, US Purpose: Ceramic on ceramic (COC) is an attractive option for total hip replacement, but little data exists on the alumina matrix composite at midterm follow-up. This study reports the midterm results of an IDE study utilizing Biolox Delta COC. Method: Three hundred and forty five patients received a Delta COC THA from 2003-2007 as part of a prospective multicenter IDE study with head sizes of either 28mm (n=177) or 36mm (n=168). Average patient age was 56.9 years and average BMI was 29.5. All patients were followed yearly with clinical and radiographic evaluations. Results: The survivorship estimate was 97.7% at 6.3 years with 95% confidence intervals (CI) of 95.1% to 98.9%. Survivorship estimates by head size were 97.7% (95% CI 93.9% to 99.1%) at 6.3 years for 28mm head sizes and 97.5% (95% CI 92.0% to 99.2%) at 4.2 years for 36mm. There were 15 (4.3%) individuals who reported squeaking, 6 (3.4%) in the 28mm group and 9 (5.4%) in the 36mm group. Only 2 (0.58%) were reproducible in the clinic and none were revised for squeaking. There were 3 (0.85%) postoperative liner fractures (2 in 28 mm (1.1%), 1 in 36 mm (0.6%)) and no ball head fractures. Conclusion: The COC articulation has excellent 6 year survivorship of 98%. Although rare, squeaking and liner fractures remain the weaknesses of this bearing articulation. 113: Early High Failure Rate of Large Head Metal-on-Metal Total Hip Replacement Using a Mono Block Acetabular Component Vikram Chatrath, ON; Paul E Beaulé, ON; Robert Feibel, ON; Peter Thurston, ON; Isabelle Catelas, ON; Paul R Kim, ON Purpose: The purpose of this study is to present the early clinical results of our center’s experience with the use of large head MOM total hip replacement with a mono block acetabular component. Method: From October 2005 to May 2010, 89 procedures were performed in 88 patients (53 males, 35 females) by four surgeons usi Femoral Head) which uses a large diameter femoral head (36-54 mm). The mean age of patients was 59.7±9.8 years (20 to 79). Mean BMI was 29.5±6.2 (21.2 to 44.8). Post-operative clinical follow-up consisted of a physical examination, standard radiographs, and three patientreported outcomes: WOMAC, modified Harris Hip Score (HHS), UCLA Physical Activity Scale. Results: At mean follow-up (28 months, range: 14-65), all outcome scores showed improvement (p<0.001). Scores were 13.7 vs. 51.0 pre-surgical (WOMAC Pain), 22.1 vs. 56.0 (WOMAC Stiffness), 14.8 vs. 53.4 (WOMAC Function), 15.1 vs. 53.1 (WOMAC Total), 83.2 vs. 53.7 (modified HHS), and 6.7 vs. 4.8 (UCLA Activity). However, eight cases required revision at a mean of 29.9 months (range: 11 to 45). Reasons for revision: aseptic cup loosening (n=4), pseudotumor (n=2), hypersensitivity to metal (n=1), and infection (n=1). At <3 years, our failure rate for aseptic failure is 8.9%. Conclusion: The current study reports a high failure rate of a large head MOM total hip replacement due to poor acetabular component fixation as well as adverse tissue reaction. Use of this implant should be restricted to conversion of a failed resurfacing arthroplasty. 114: Metal on Metal versus Polyethylene in Total Hip Arthroplasty: Ten-Year Results of a Randomized Clinical Trial Joseph B Assini, ON; Steven JM MacDonald, ON; Richard W McCalden, ON; Robert B Bourne, ON Purpose: To present the long-term results of a randomized clinical trial examining metal ion levels in metal on metal (MoM) versus metal on polyethylene (MoP) bearing surfaces in total hip arthroplasty. Method: Forty-one (24 male, 17 female) patients undergoing total hip arthroplasty were randomized to receive either a metal (23 patients) or polyethylene (18 patients) acetabular insert. Patients were followed prospectively for a minimum of 10 years (mean 11.2 years, range 10.1-11.9 years). Clinical, radiographic and metal ion analyses were done preoperatively, and at 2, 5, 7 and 10 years postoperatively. Clinical outcome measures included the Harris Hip score (HHS), Western Ontario MacMaster University Score (WOMAC) and Short-Form 12 (SF12). Metal ion analysis evaluated the erythrocyte ion levels of cobalt, chromium and titanium and the urine concentration of cobalt and chromium ions. Results: Clinical outcome measures demonstrated no differences between metal on polyethylene and metal on metal groups at 10 year follow-up. There were no radiographic differences between groups. Patients in the MoM group were found to have a 5-fold increase in erythrocyte cobalt levels at 10 years post-operative. Additionally, the urine cobalt and chromium levels demonstrated 13.9-fold and 11.8-fold increases respectively. In the MoP group only the erythrocyte chromium levels increased significantly over the 10 years of followup, demonstrating a 2.4-fold increase. Comparison of the MoM versus MoP groups showed a significant difference in the median erythrocyte cobalt (0.7 ug/L vs. 0.1 ug/L, p<0.01), urine cobalt (5.86 vs. 0.38, p<0.01) and urine chromium (3.05 vs. 0.23, p<0.01) levels. There were no failures, revisions or patients diagnosed with metal hypersensitivity. Conclusion: Compared to metal on polyethylene, metal on metal articulations were found to produce increased erythrocyte cobalt and urine cobalt and chromium levels at 10 years postoperatively. The elevated metal ion levels that were seen early in followup in this series have not decreased or diminished over time. To date, there have been no identified complications associated with the metal on metal bearing cohort. 115: One Intraoperative Dose of Tranexamic Acid is Safe and Effective in Revision Total Hip Arthroplasty Kevin Smit, ON; Douglas Naudie, ON; James L Howard, ON Purpose: Revision total hip arthroplasty (THA) has been associated with an increased risk of perioperative blood loss requiring transfusions. Tranexamic Acid (TXA) has been proven to be safe and effective in preventing blood loss in primary THA. Our purpose was to study the effect of TXA on blood loss and transfusion rates in revision THA. Method: We performed a retrospective comparative study on 343 patients who had undergone revision THA between January 2006 and March 2010. 108 patients did not receive TXA while 235 patients received one intraoperative dose of 20 mg/kg of TXA given immediately before skin incision. We then compared change in hemoglobin, transfusion rates, hospital length of stay, and complications between the two groups. No other routine patient care practices or blood conservation program strategies were altered during this time. Results: There was a significant reduction in hemoglogin (Hb) loss in the TXA group compared to the No TXA group for revision THA (48 ± 18 g/L and 43 ± 18 g/L, respectively, p=0.01) and a significant reduction in transfusion rates (45.4% and 33.6%, respectively, p=0.03) and average amount transfused (1.3 ± 1.9 units and 0.9 ± 1.6 units, respectively, p=0.03). The effect of TXA on Hb loss was most significant in procedures that involved revision of both the femoral and acetabular components (58 ± 18g/L and 49 ± 15g/L, respectively, p=0.01). There was not a significant difference in recorded major adverse events with the administration of TXA (nine and nine respectively). Conclusion: One 20 mg/kg intraoperative dose of TXA significantly reduced red blood cells loss and transfusion rates in patients undergoing revision THA compared to a patient cohort whom did not receive the TXA protocol. This single dose protocol was not associated in an increased complication rate. 116: Outcome Comparison of Revised Hip Resurfacing with Primary and Revised Total Hip Arthroplasties William Desloges, ON; Toru Nishiwaki, ON; Paul R Kim, ON; Kyle Kemp, ON; Paul E Beaulé, ON Purpose: A clinical advantage of hip resurfacing (HR) is the preservation of femoral bone, facilitating revision surgery when indicated. To determine if patients: 1) undergoing HR revision have comparable outcomes to patients undergoing primary THA or revision of primary THA; 2) undergoing revision of both the femoral and acetabular HR components have different outcomes than those undergoing isolated femoral component revision. Method: Twenty-two HR patients who underwent HR revision to a THA were retrospectively reviewed and compared to 23 matched (age, gender, BMI) patients undergoing primary THA and 12 patients undergoing revision of primary THA. Patients completed the WOMAC and SF12 questionnaires prior to surgery and at latest follow-up. Blood loss, days in hospital, complications, and outcome scores were compared between groups. Results: The HR revision group had greater intraoperative blood loss compared to the primary THA group (p= 0.002), but not the THA revision group. At follow-up, no differences in SF-12 scores were present, but higher WOMAC stiffness (p=0.014), function (p=0.016) and total (p=0.033) scores were observed in the HR revision group, compared to primary THA. HR patients undergoing revision of both components compared to femoral side only had comparable SF-12, WOMAC stiffness, function, and total scores but overall higher WOMAC pain scores (p=0.050). Conclusion: Our results indicate the outcomes of HR revision are comparable to THA revision, but not primary THA. Longer follow-up is required to determine if these differences persist. Finally, HR patients undergoing revision of one or both components can expect similar outcomes. 117: Porous Metal Revision Shells for Management of Contained Acetabular Bone Defects at 5 to 10 Years Follow-up Paul RT Kuzyk, ON; Amir Sternheim, ON; David Backstein, ON; George Goshua, ON; Yaron Berkovich, ON; Oleg Safir, ON; Allan Gross, ON Purpose: Porous metal acetabular revision shells were used to treat contained bone loss. Method: Outcomes of 53 patients with less than 50% acetabular bleeding host bone contact were compared to a control group of 49 patients with 50%-85% bleeding host bone contact. All patients were treated with the same type of porous metal shell. Minimum follow-up in both groups was 5 years (mean 72.4 months). Clinical, radiographic and functional outcomes were assessed. Results: There were 4 (7.5%) mechanical failures in the less than 50% host bone contact group and no failures in the more than 50% host bone contact group (p-value 0.068). There were 4 infections (3.9%) and 5 recurrent dislocations (4.9%) with a stable cup construct that were revised to a constrained liner in both groups combined. Conclusion: Given the complexity of the reconstructive challenge, porous metal revision acetabular shells show highly acceptable failure rates at 5 to 10 years follow-up in the setting of significant contained bone defects. This favorable outcome may be due to the improved initial stability achieved by a high friction coefficient and the high porosity with better bone ingrowth. 118: Reconstruction of Acetabular Bone Deficiency in Revision Total Hip Arthroplasty with Shelf Grafts in Hip Dysplasia A Long –Term Survivorship Comparison between Cemented and Uncemented Cups Paul RT Kuzyk, ON; Amir Sternheim, ON; Yaron Berkovich, ON; Oleg Safir, ON; David Backstein, ON; Allan E Gross, ON Purpose: Long term outcomes of cemented and uncemented cups were compared in patients with hip dysplasia that had previously undergone revision hip arthroplasty. In the indexed revision hip arthroplasty all the patients had an uncontained superolateral acetabular defect which was reconstructed with a structural allograft. Method: In this retrospective study long term outcomes of cemented and uncemented acetabular cups were compared. Thirty-nine patients (46 hips) included in this study had previous hip dysplasia and had undergone a hip arthroplasty which failed due to loosening. Inclusion criteria for the study were previous dysplasia, a superolateral acetabular rim defect which was reconstructed with a shelf allograft at the time of revision hip arthroplasty. Nineteen cemented acetabular cups were compared to 27 uncemented acetabular cups. Average followup was 210 months (range, 96-305) in the uncemented group and 253 months (range, 162312) in the cemented group. The average age at surgery was 52 years in the uncemented group and 54 years in the cemented group. The primary outcome assessed was failure and revision of the acetabular cup. Secondary outcomes were failure of the shelf grafts. Survivorship analysis was calculated with Kaplan-Meier curves and Log-rank analysis was used to compare the survival. Results: At an average follow-up of 221 months, 18 acetabular cups (39%) failed due to loosening and were revised. The 10, 20 and 25 year cup survival was 88%, 76% and 76% in the uncemented group and 68%, 51% and 24% in the cemented group. Log rank analysis showed a significant difference (P value 0.0172) between the two groups with regard to implant survival. Only one shelf graft was revised. Conclusion: Uncemented acetabular cups performed significantly better than cemented cups in dysplastic hips after revision arthroplasty and an uncontained acetabular defect which was reconstructed a shelf allograft. 119: The Mid-term Outcome of 75 Consecutive Constrained Acetabular Components in Total Hip Arthoplasty Robert Fassina, ON; Richard McCalden, ON; James L Howard, ON; Douglas Naudie, ON; Steven JM MacDonald, ON; Robert B Bourne, ON Purpose: Instability following total hip arthroplasty (THA) continues to be problematic for both surgeon and patient. The use of constrained acetabular liners are most commonly used in the salvage situation when other soft tissue tensioning techniques or implant options have failed to offer adequate stability. The purpose of this study is to prospectively evaluate the mid-term outcomes of a single design (Stryker/Osteonics) constrained acetablular component in the management of instability following THA. Method: Between 1994 and 2011, 75 Styker/Osteonics constrained acetabluar liners were inserted and followed prospectively in 75 patients. The vast majority were performed as revision surgeries having at least one prior arthroplasty. The main reason for revision was instability (greater than 50%) although included two-stage revision for infection, aseptic loosening, osteolysis, periprosthetic fracture and conversion from bipolar hemiarthroplasty. Constrained liners were performed as the primary arthroplasty procedure in eight cases. Seven of these were performed following failed fixation of neck of femur fractures and one in a patient with muscular dystrophy with osteoarthritis. Patients were followed prospectively using validated clinical outcome scores (WOMAC, SF-12, Harris Hip scores) and radiographs. Kaplan-Meier survival analysis was performed. Results: Mean follow-up was 36 months (range, 1.5- 108 months). Ten of the patients had died with out adequate radio-clinical follow-up although none had undergone further revision. Of the remaining patients, WOMAC and Harris Hip Score were significantly improved from preoperatively to last follow-up (64.9 and 77.4 respectively). To date, five revision procedures have been performed. Only one revision was performed for ongoing instability in a case where the capture mechanism had failed. One revision was performed for aseptic loosening, two revisions for pelvic dissociation following a fall and concurrent acetabular fracture, and one revision for septic loosening. Kaplan Meier survivorship analysis of the capture cup system with revision for dislocation as the outcome was 98.6% (97.2 to 100%) at 5 years and for revision for any reason was 91.1%(87.6 to 94.6%) at 5 years. Excluding revision for infection survivorship was 93.9% (90.9 to 96.9%) at 5 years. Conclusion: The Stryker/Osteonics constrained acetabular component offered reliable fixation and joint stability in patients with known and potential instability of their total hip arthroplasty. 120: Total Hip Arthroplasty after Chiari Pelvic Osteotomy Nemanja Slavkovic, Anica Bitenc Fellow (Serbia) Purpose: Karl Chiari introduced specific dome pelvic osteotomy in the 1950s. In the next three decades he repeated same surgical procedure more then 2000 times without any changing. Chiari pelvic osteotomy became very popular and wide performed. Original surgical technique is modificated and improved during the time. Nevertheless, the basic idea is left unchanged – increasing of the femoral head coverage by medial displacement of the distal part of the pelvis, including hip, along with capsular interpositioning. Method: Chiari pelvic osteotomy has lost its actuality and importance during this past six decades. The role of Chiari pelvic osteotomy has been significantly taken over by other, more efficient and more lasting surgical procedures. Nevertheless, Chiari pelvic osteotomy is still present in modern orthopedic practice, above all as “salvage” osteotomy. Results: Chiari pelvic osteotomy changes biomechanical features of the hip joint and may compromise subsequent total hip arthroplasty or make it far more difficult. I evaluated outcomes of patients with dysplastic hips treated at Institute for Orthopaedic Surgery “Banjica” with total hip replacement after Chiari pelvic osteotomy. Patients charts and radiographs were available and reviewed. I analyzed position of the acetabular endoprosthesis component, all perioperative complications and causes for acetabular and femoral component revisions. Conclusion: Alterations in Harris hip score and endoprosthesis survivorship were analyzed regarding some radiographic parameters (the angle of the osteotomy, the distance of the osteotomy from the acetabular edge and the percentage of medial displacement of inferior pelvic fragment at the level of osteotomy). 121: A Comparison of Bone Geometry and Microstructure Between the Dominant and Non-dominant Radius of Children Kishore Mulpuri, BC; Jeanie Zabukovec, BC; Firoz Miyanji, BC; Chris Reilly, BC; Heather Macdonald, BC; Christa Hoy, BC; Douglas Race, BC; Meghan Donaldson, BC; Heather McKay, BC Purpose: There is a positive relationship between physical activity and bone mass. Using imaging systems such as peripheral quantitative computed tomography (pQCT) and dualenergy X-ray absortiometry (DXA), recent studies quantified significant differences in bone geometry and bone mineral density or content between dominant and non-dominant hands and humeri. Whether differences also exist in children and for bone microstructure has yet to be determined. Should they be present, deficits may contribute to fractures which represent about 10-25% of all pediatric trauma. Therefore the purpose of this study was to compare bone microstructure in the dominant versus non dominant radius in children. Method: We used high-resolution pQCT (HR-pQCT) to assess cortical density, cortical area, cortical thickness, total density, total area, as well as trabelcular area, density, number, separation and thickness. All measures were acquired at the 7% site of left and right radii. We assessed n=79 children (aged 8-14y), 68 were right hand dominant (M=35, F=33; age= 12.1±1.66y, BMI= 19.5±3.98) and 11 left hand dominant (M= 3, F= 8; age= 11.09±1.26y, mean BMI= 19.3± 2.96). (All mean±SD) Results: Cortical area and cortical thickness were approximately 13% greater in the dominant versus non dominant radius (16.52mm^2± 10.89 vs. 14.34 mm^2± 10.89; and 0.2743mm±0.178 vs. 0.238mm± 0.183, respectively) (p=0.003 both). There were no other differences for any variable between dominant and non-dominant radii. Conclusion: The increased loads experienced by the dominant arm significantly enhance cortical bone geometry of the preferred side. This may offer some protection to the dominant side or conversely place the non-dominant side at greater risk of fracture during a fall. The structure of the cortex provides substantial strength to long bones. Thus, a smaller cortical area and thickness in the non-dominant compared to the dominant radius supports (in part) evidence of an increased fracture rate in the non-dominant arm in this young population. 122: Acute Kidney Injury in the Pediatric Intensive Care Unit following Spinal Surgery: A Retrospective Study Cherry Mammen, BC; Abdullah Alabbas, BC; Kishore Mulpuri, BC; Christopher S Reilly, BC; Peter Skippen, BC Purpose: Acute kidney injury (AKI) has replaced the earlier term, acute renal failure. AKIN (Acute Kidney Injury Network) classification system has been developed to allow a comparison between different studies and populations. AKIN consists of three severity stages: one (mild), two (moderate), and three (severe), based on specified changes in serum creatinine (S.Cr) compared to baseline or the duration of reduced urine output (UO). A recent adult study revealed an AKI incidence of 16% following hip fracture surgery, however there is no literature investigating the potential of children undergoing spinal surgery. The purpose of this study was to 1) define incidence of AKI in patients admitted to the Pediatric Intensive Care Unit (PICU) following spinal instrumentation surgery and 2) describe the clinical characteristics of these children utilizing the AKIN definition. Method: This is a retrospective, single center observational design. We included all postoperative spinal surgery admitted to our PICU between January 2006 and December 2008 with AKI defined by their maximal AKIN stage (UO or S.Cr criteria). Patient data was collected from a PICU database and medical charts. Results: We identified 23 out of 169 post-spinal surgery children with AKI. PRISM III (Pediatric Risk of Mortality Score) was low with a mean of 5±3.8. Ten (43%) needed invasive ventilation. The mean PICU length of stay was 3.17±2 days. 14 (61%) patients were given NSAIDs (mostly IV Ketorolac) while four (17.4%) received aminoglycosides. The mean weight and baseline S.Cr were higher in the idiopathic scoliosis (n=13) group (57.4±11.5 kg and 55±11 umol/L respectively) in comparison to the non-idiopathic group (eight cerebral palsy/neuromuscular, one spinal stenosis and one spondylolisthesis) with mean 47.8±23.3 kg and 34.3±15 umol/L. The mean total IV fluids (cc/kg/day) given on the first day of surgery was lower with worsening severity of AKI (130±61 (stage one) vs 60±17.5 (stage two) vs 52 (stage three)). Baseline serum sodium increased from mean 140±2.5 to 144±3.3 mmol/L during PICU admission. Seventeen (74%) patients had their AKI identified on the day of surgery. Almost all AKI (95%) was defined by the AKIN UO criteria alone. None needed dialysis or died. Conclusion: AKI incidence (14%) is common in this population. The use of nephrotoxic medications was high (70% of patients). Severe AKI patients (stage two & three) were given less fluids on the day of surgery as compared to those with milder injury (stage one). Serum sodium rose to high-normal values in most patients. Most AKI patients were defined by the AKIN UO criteria only and may have not been identified by the change in S.Cr criteria because of the lower muscle mass associated with the non-idiopathic group. Relative dehydration is a possible risk factor for AKI in this population. A larger prospective study is needed to confirm the incidence and potential predictors for this group. 123: Do Surgical Wait Times affect Surgical Treatment and Peri-operative Management of Patients with Cerebral Palsy and Subluxated or Dislocated Hips: The Surgeons Kishore Mulpuri, BC; Megan S Cashin, BC; Henry Chambers, US; Benhamin Joseph, US; Kerr Graham, VIC Purpose: At our institution, many children wait more than one year for hip surgery for hip subluxation/dislocation. The purpose of our study was to investigate the changes in severity of hip subluxation/dislocation over time and how this might impact the type of surgery performed and the associated peri-operative health resource utilization. Method: 19 children who had waited a minimum of one year for surgical treatment of hip subluxation or dislocation secondary to cerebral palsy were identified during an audit. The children are patients at a tertiary children’s hospital. Two sets (AP and frog lateral) of radiographs were selected for each patient at two different time points (38 total x-rays). These radiographs and a questionnaire were sent to three pediatric orthopaedic surgeons specializing in the hip. The surgeons were selected from three centers in three countries for an international perspective. The surgeons were blinded to the fact that these radiographs were from the same patients at two time points. The questionnaire requested information regarding the type of surgery they would perform, peri-operative variables, and Graham Classification. Results: The study group included 10 males and nine females. Mean age at baseline was 6.5 years. Average time between first and second x-ray was three years. Mean Reimers migration percentage on baseline was 54.0 (95%CI 47.2, 60.8) and change in Reimers score between xrays was 26.0,(95%CI 0.3,51.7). Combining estimates of blood loss across the three surgeons, at first x-ray the percentages in each category were: Less than 100 ml 28.1%, from 100 to 250 10.5%, between 250 and 500ml 36.8% and 500 to 1000 ml 14.0% with 6/19 cases not estimated. At second x-ray, the estimates of blood loss for the same categories were 1.8%, 8.8%, 54.4% and 21.1% respectively. Mean length of surgery at time one was estimated to be 1.8 hours (95%CI 1.5, 2.1). At time two it was 2.3 hours (95%CI 2.1, 2.5) Mean estimate of difficulty was 3.8 out of a score of 10 with 95%CI 3.2, 4.4. At follow-up the mean was 5.0 (95% CI 4.6, 5.4). Graham Classification agreement was strong with 43/57 (75%) accuracy between first and subsequent x-rays. Combining all surgeons’ observations, the kappa was 0.59, considered to be excellent agreement. Conclusion: From a surgeon’s perspective, waits of 12 months or more for CP hip surgery are unacceptable as they lead to the need for a more complex procedure that probably would have not been necessary had the operation occurred earlier. It also leads to increased operative time, blood loss, length of stay, and difficulty of surgery. This, in turn, increases unwarranted risks and costs. It is imperative that health policy decision makers’ work to reduce waiting times for CP hip surgery, as increased waiting times have serious implications for the health of the child as well as for costs to the healthcare system. 124: Does the Type of Distraction-based Growing System for Early Onset Scoliosis Affect Post-operative Sagittal Alignment? Ron El-Hawary, NS; Peter Sturm, US; Patrick Cahill, US; Amer Samdani, US; Michael Vitale, US; Peter Gabos, US; Nathan Bodin, US; Colin Harris, US; Charles d'Amato, US; John Smith, US Purpose: Rib-based (RB) and spine-based (SB) posterior distraction growing systems are commonly used for the treatment of early onset scoliosis (EOS). The purpose of this study was to determine if the type of growing system affects post-operative sagittal-plane alignment. Method: A multi-center, retrospective, IRB-approved radiographic comparison was performed. Pre-operative and minimum 2-year follow-up radiographs were analyzed for a group of 79 children with EOS who were treated with posterior distraction-based implants. Results: There were 56 subjects treated with rib-based and 23 subjects treated with spinebased systems. Mean pre-operative values for rib vs spine-based systems were: Age (4.4 vs 6.3 yr)*, Thoracic scoliosis (70.4° vs 74.8°), lumbar scoliosis (34.6° vs 40.1°), thoracic kyphosis (36.6° vs 40.0°), and lumbar lordosis (45.7° vs 54.9°)*. Other than sacral slope (34.9° vs 39.7°)*, sagittal spinal and pelvic parameters were similar between groups.At minimum 2 yr follow-up (3.5 yr RB vs 2.1 yr SB)*, curve correction was less for the rib-based group: 20.9% vs 47.5% thoracic* and 19.3% vs 48.9°% lumbar*. The rib-based group had greater cervical lordosis (36.4° vs 21.4°)*, greater thoracic kyphosis (46.2 vs 26.0°)*, less lumbar lordosis (46.4 vs 53.5°), less sacral slope (34.8 vs 40.0°)*, greater pelvic tilt (18.0° vs 11.1°)*, and less pelvic radius angle (49.8° vs 66.4°)*. Pelvic incidence was not different between groups. (* denotes p<0.05). Conclusion: Although longer follow-up for the rib-based group is a potential confounding variable; at final follow-up, subjects treated with rib-based implants had greater cervical lordosis, greater thoracic kyphosis, less lumbar lordosis, less sacral slope, greater pelvic tilt, and less pelvic radius angle as compared to those treated with spine-based implants. Ribbased and spine-based implants result in different post-operative sagittal profiles. The patient’s pre-operative sagittal alignment should be considered when deciding upon which type of distraction-based growing system to use for an individual patient with EOS. 125: The Effects of Obesity on Deformity Correction in Adolescent and Juvenile Idiopathic Scoliosis Jochen Son-Hing, US; Christina K Hardesty, US; Connie Poe-Kochert, US; George H Thompson, US Purpose: Obesity is associated with an increased rate of complications in the peri-operative period, especially in adults. An elevated body mass index (BMI) has been related to greater preoperative thoracic kyphosis in children compared to those with a healthy weight. This retrospective analysis was done to examine the relationship between BMI and surgical outcomes in adolescent and juvenile idiopathic scoliosis. Method: A retrospective review of our computerized pediatric spinal deformity database was performed. Two hundred and thirty-six patients with idiopathic scoliosis underwent spinal deformity correction surgery between 1992 and 2010. Demographic data, radiographic measurements, intraoperative and postoperative data, and complications were collected. The BMI was calculated for each patient. Pearson correlation coefficients were calculated to evaluate the correlation between BMI and each of the outcome measures. Results: Two hundred and thirty-six patients (187 females, 49 males) with an average age of 14.43 years (range 11-22 years) with a minimum of one year follow up met the inclusion criteria for this study. The average BMI was 21.63 (range 10-46). The pearson correlation coefficient was highest for preoperative thoracic kyphosis at 0.75. The correlation was lower (0.25), for total operative time and amount of fluids given intraoperatively. The amount of intraoperative blood loss, postoperative drainage, and total blood loss did not show any significant correlation. The correction of deformity was also similar regardless of BMI. The percent complication rate was much higher in the obese children (39%) compared to healthy children (15%). Obese children were unable to receive a pre-operative spinal anesthetic 17% of the time compared to 1% of the healthy children. Conclusion: An increased BMI in adolescents and juveniles undergoing spinal deformity surgery correlated strongly with increased preoperative kyphosis, number of postoperative complications, and difficulty with administration of spinal anesthesia. An increased BMI correlated less strongly with total operative time and amount of fluids required intraoperatively. There was no significant correlation with intraoperative blood loss, postoperative drainage, total blood loss, or correction of curvature. 126: Extension Type II Paediatric Supracondylar Humerus Fractures: Long Term Results of Closed Reduction and Cast Immobilization Scott Williams, NS; Tristan Camus, AB; Brent Maclellan, NS; Tricia Lane, NS; Kyleigh Woods, NS; Ron El-Hawary, NS Purpose: The treatment of Gartland type II supracondylar humerus fractures remains controversial. It has recently been published that only half of these fractures treated with closed reduction and cast immobilization achieved anatomical radiographic position and alignment at short term follow-up. The purpose of this study was to determine the long term clinical and radiographic outcomes of closed reduction and casting of extension type II supracondylar humerus fractures. Method: Patients who were treated for an extension type II supracondylar fracture at our institution with a minimum of five-year follow-up were identified and invited to participate in the study. We examined both radiographic and clinical outcomes in subjects for both their affected and unaffected extremities. Results: The average age of the 16 subjects at the time of injury was 5.3 years (1-9yr) and their average follow-up was 9.6 years (6-16 years). Radiographic results for affected vs. nonaffected extremities: Anterior humeral line was central in 7 of 16 vs. 16 of 16 elbows , humerocapitellar angle was 51.7° (SD 7.4°) vs. 50.6° (SD 8.7°), Baumann’s angle was 81.0° (SD 12.4°) vs. 79.6° (SD 6.2°), ulnohumeral angle was 4.3° (SD 6.3°) vs. 10.2 ° (SD 3.9°) (p<0.003). Clinically, for affected vs. non-affected extremities: Active flexion was 148.7° (SD 7.4°) vs. 152.5° (SD 6.7°)(p<0.02), passive flexion was 154.3° (SD 7.9°) vs. 157.5° (SD 9.6°), active pronation was 84.8° (SD 8.0°) vs. 86.4° (SD 6.7°), passive pronation was 96.3° (SD 10.0°) vs.97.3° (SD 9.6°), active supination was 98.8° (SD 13.9°) vs. 99.4°(SD 15.0°), passive supination was 107.4° (SD 14.6°) vs. 110.0° (SD 15.6°), and carrying angle was 5.4° (SD 5.1°) vs. 9.9° (SD 3.0°)(p<0.005). All subjects had satisfactory active and passive motion, while 14 of 16 subjects had satisfactory carrying angle using Flynn Criteria. Conclusion: Long term follow-up of these patients demonstrated statistically significant differences between affected and non-affected elbows for active flexion, carrying angle, position of anterior humeral line, and the ulnohumeral angle. Despite these statistically significant differences, the relative cubitus varus and mild limitation in flexion arc for the majority of patients treated with closed reduction and casting are likely clinically insignificant. 127: Management of Distal Metaphyseal and Diaphyseal Radius/ Ulna Fractures in Children Presenter: Ritesh Khokhar Purpose: We decided to evaluate the outcome (in terms of redisplacement and residual deformity) of displaced distal metaphyseal and diaphyseal radius/ulna fracture treatment in paediatric age group: Manipulation under anaesthesia (MUA) with plaster cast versus surgical stabilisation (pinning). Method: We conducted a retrospective analysis from case notes (Blue Spier electronic patient data record system) and radiographs of 150 children aged 0 to 16 yrs with displaced distal metaphyseal and diaphyseal radius/ulna fractures. Results: 33 % of distal metaphyseal radius fractures redisplaced with majority (72%) in MUA with cast group. Almost all redisplacements had associated ulna fracture. 43 % of these displaced fractures underwent another procedure for correction of deformity. 15 % of diaphyseal radius fractures redisplaced with majority (90 %) in MUA with cast group. Almost all redisplaced diaphyseal radius fractures had associated ulna fracture. 10% of these displaced fractures underwent further procedure for correction of the deformity. Complication rate with pinning was very low (< 1%). No long term complication was encountered with pinning. Conclusion: It is advisable to do pinning rather than MUA with cast only for displaced distal metaphyseal and diaphyseal radius/ulna fractures requiring intervention. 128: Sagittal Spinopelvic Parameters Help Predict the Risk of Proximal Junctional Kyphosis for Children Treated with Posterior Distraction Based Implants Ron El-Hawary, NS; Peter Sturm, US; Patrick Cahill, US; Amer Samdani, US; Michael Vitale, US; Peter Gabos, US; Nathan Bodin, US; Charles d'Amato, US; Colin Harris, US; John Smith, US Purpose: Rib-based (RB) and spine-based (SB) posterior growing systems are commonly used for the treatment of early onset scoliosis (EOS). The purpose of this study was to determine if pre-operative spinopelvic parameters can predict the risk of post-operative proximal junctional kyphosis (PJK). Method: A multi-center, retrospective, IRB-approved radiographic comparison was performed. Pre-operative and minimum 2-year follow-up radiographs were analyzed for a group of 40 children with EOS who were treated with posterior distraction-based implants (24 RB, 16 SB). PJK was defined as proximal junction sagittal angle (PJA) >/= 10° and PJA at least 10° greater than preoperative. Results: At a minimum of two year follow-up, 11 subjects (27.5%) developed PJK. Follow-up time was not different between groups (2.4 yr PJK vs 2.9 yr No PJK); however, there was a significant difference in age at time of initial surgery (7.1 yr PJK vs 5.0 yr No PJK)*. The rates of PJK were similar between rib-based and spine-based growing systems (25% vs 31%). Preoperative radiographic comparisons between PJK vs No PJK: Thoracic scoliosis (69.9° vs 76.0°), lumbar scoliosis (38.8° vs 39.1°), thoracic kyphosis (45.1° vs 28.7°)*, thoracolumbar kyphosis (3.6° vs 12.5°), lumbar lordosis (53.1° vs 44.0°), PJA (2.2° vs 2.8°), sagittal balance (1.5 cm vs 2.6 cm), pelvic incidence (52.8° vs 47.4°), pelvic tilt (14.3° vs 8.7°), sacral slope (37.7° vs 35.9°), pelvic radius angle (72.7° vs 67°).At final follow-up, differences were found for cervical lordosis (30° vs 16.6°)*, PJA (21.9° vs 3.1°)*, sagittal balance (3.7 cm vs 0.2 cm)*, and pelvic radius angle (79.1° vs 62.2°)* (* denotes p<0.05). Conclusion: Higher rates of PJK were found for older children who were hyperkyphotic preoperatively and in those who had positive post-operative sagittal balance. Older age and preoperative hyperkyphosis may increase the risk of developing PJK. Strategies to intraoperatively restore normal sagittal balance may help avoid the development of PJK in children treated with growing systems for EOS. 129: The Clinical Stability of Lateral Pinning in the Surgical Treatment of Supracondylar Humeral Fracture with Medial Column Involvement in Children Mathilde Hupin, QC; Louis-Philippe Charette, QC; Constantin Stanciu, QC; Stefan Parent, QC; Jean-Marc Mac-Thiong, QC Purpose: Previous biomechanical studies have been done to determine the stability of different pinning configurations for fixating supracondylar humeral fractures in children when there is medial column comminution or extension. However, no clinical study has been conducted so far to evaluate the effectiveness of various pinning configurations when there is involvement of the medial column associated with supracondylar humeral fractures in children. The purpose of our study was to evaluate the clinical stability of the lateral entry pinning techniques for unstable supracondylar humerus fractures in children with medial column comminution or extension. Method: We reviewed all Gartland type II/III supracondylar humerus fractures treated surgically at a single paediatric institution from January first, 2002 to January first, 2011. Patients were included in this study if they had: 1) involvement of the medial column as defined by medial comminution or extension proximal to the olecranon fossa, and 2) treatment by closed reduction followed by lateral percutaneous pinning. From all 412 patients reviewed, 17 aged 5.6 ±2.2 years (range: one-10 years) fulfilled the inclusion criteria and were kept for further analysis. The Baumann’ angle and the capitellohumeral angle were compared between the C-arm images taken at the time of surgery and the postoperative radiographs taken three weeks after the surgery after the pin removal. Loss of reduction was defined as a change in Baumann’s angle or in capitellohumeral angle of more than six degres and 10 degres respectively. Results: The Baumann’s angle and capitellohumeral angle were respectively 74±six degres (median:75°; range:60-86°) and 44±15° (median:48°; range:16-72°) at the time of surgery. After pin removal, Baumann’s angle and capitellohumeral angle were respectively 77±seven degres (median:78°; range:77-90°) and 41±11° (median:41°; range:21-64°). According to our predetermined criterias defining loss of reduction, 11 of our 17 patients (65%) had failed to maintain the alignment. Conclusion: In the current study, we have found that lost of reduction occurred in 65% of the 17 patients with supracondylar humerus fractures with medial column involvement. This observation is in accordance with previous biomechanical studies suggesting the lack of mechanical stability provided by lateral pinning only in the presence of medial column comminution or extension. Clinicians should be aware of the significant instability related with supracondylar humerus fractures in children with medial column involvement. Therefore, lateral pinning only may not provided adequate clinical stability in these situations. Further studies should be address comparing lateral and crossed pinning in operative treatment of these fractures. 130: Use of Bipolar Sealer Device Reduces Blood Loss and Transfusions in Posterior Spinal Fusion Jochen Son-Hing, US; Zachary L Gordon, US; Connie Poe-Kochert, US; George H Thompson, US Purpose: Reducing perioperative blood loss and transfusions in patients undergoing posterior spinal surgery is important. Since 2001, all our pediatric patients have received epsilon aminocaproic acid (Amicar) to reduce perioperative blood utilization. To reduce blood loss and transfusions further, we are using a bipolar sealer device (Aquamantys, Salient Surgical Technologies) as an adjunct to electrocautery. Method: Using a prospectively maintained database, we reviewed the operative time, estimated blood loss, cell saver use, and intraoperative and postoperative transfusion rate in patients who underwent posterior-only spinal fusion for idiopathic scoliosis. Fifty patients were identified who fit these criteria since initial use of the bipolar sealer device. We compared these patients to a control group of the preceding fifty patients for whom the device was not used. All patients, including those in the study group, received Amicar (infusion of 100 mg/kg over 15 to 20 minutes, then 10 mg/kg per hour throughout the remainder of the procedure). The surgical technique did not differ between the two groups. Results: Baseline characteristics between the two groups were similar except for the number of levels fused, which was larger in the investigational group (12.5 versus 11.8, p=0.027). There was no difference in operative time or hospital length of stay. Intraoperative blood loss was 597mL in the study group and 1085mL in the control group (p<0.0001). Total perioperative blood loss, including postoperative drain output, was 1266mL in the study group and 1600mL in the control group (p=0.01). Intraoperative cell saver transfusion was 127mL in the study group and 200mL in the control group (p=0.001). Eleven patients in the study group and twenty-six patients in the control group required additional intraoperative or postoperative transfusions (p=0.004). The number of packed red cell units transfused per patient was 0.26 in the study group and 0.58 in the control group (p=0.034), reducing the transfusion rate by over 50%. Total blood volume transfused, including cell saver, was also significantly lower in the study group (212mL vs. 388mL, p=0.001). Conclusion: Use of a bipolar sealer device significantly reduces total perioperative blood loss and transfusion requirements, when compared with a control group in posterior spinal surgery for idiopathic scoliosis. 131: A Comparative Study of Posterior Fixation in Acute Unstable Thoracolumbar Injuries by Monoaxial and Polyaxial Pedicle Screws Rajeshwar Nath Srivastava, IN; Pradeep Singh, IN Purpose: The treatment of unstable thoracic spine fractures remains controversial. Theoretical biomechanical advantages of transpedicular screw fixation include three-column control of vertebral segments and fixation of a vertebral segment in the absence of intact post-erior elements. Additionally, pedicle screw constructs may obviate the need for neural canal dissection and potential neural element impingement by intracanal instrumenta-tion. A prospective longitudnal study was done to compare posterior fixation in acute unstable thoracolumbar injuries by monoaxial and polyaxial pedicle screws Method: Thirty-eight cases formed the study group as per inclusion criteria. By random allocation 18 patients were managed by polyaxial pedicle screw rod (PPSR) system-Gp A and 20 by monoaxial pedicle screw and rod system (MPSR) –Gp B. Results: In Gp A, at 1 year follow up, 12/17 (66.6%) of AIS A remained at AIS-A, 2/17 (11.11%) recovered from AIS-A to AIS-B and 1 (5.55%) recovered from AIS-A to AIS-C. 2/17 (11.11%) patients were ambulatory at 1 year and had shown full neurological recovery AIS-A to AIS-E. In Gp B, at 1 year follow up, 13/16 (81.25%) of AIS A remained at AIS-A, 2/16 (12.5%) recovered from AIS-A to AIS-B and 1/16 (6.5%) recovered from AIS-A to AIS-C. In Gp A average kyphotic angle at admission was 32o which postoperatively was re-duced to 10.3o with average correction being 21.7o, whereas in Gp B average Kyphotic angle was 26o at admission which postoperatively was reduced to 9.6o with average correction being 16.4o. Correction of 32.14 % and 35.5 % of vertebral height was achieved in Gp A and Gp B respectively after surgery. At I year follow up, average kyphotic angle in Gp A was almost same as in postoperative phase – 13.3o with a loss of 3o surgical correction. In Gp B, the average kyphotic angle was 17.6o with a loss of 8o of surgical correction. This was found to be statistically insig-nificant. The difference in the two groups was due to 3 implant failures in GP B which resulted in gross loss of surgical reduction.There were 3 implant related postoperative complication in patient fixed with monoax-ialpedicle screw (MPSR)-Gp B. In 1 the rod migrated proximally on right side and in two others there was breakage of upper two pedicle screw through neck. There was no im-plant failure in polyaxial screw rod system(PPSR)- Gp A. Rate of implant failure accounted for 15% in Gp B and this was found to be statistically significant. At 1 year, 32/38 (85.2%) were on wheel chair ambulation, 2/38 (5.26%) were walking with support and 4/38 (10.5%) were ambulatory without any aid. Conclusion: There was no significant difference in neurological recovery, pain function scores and ambulatory status in the two groups.The polyaxis facilitates surgical procedure and reduces surgical time and blood loss. Polyaxial pedicle screw is superior to monoaxial in trems of reduction, stability and implant failures. 132: Comparison of the Effectiveness of Short Course Chemotherapy with Conventional Treatment for Spinal Tuberculosis Rajendra Kumar, IN; Pranay Bhushan, IN Purpose: There is a lack of availability of a standard regimen for treatment of osteoarticular tuberculosis. As a consequence of the low incidence of osteoarticular tuberculosis in western world there is a lack of controlled trials studying the osteoarticular form of disease. From a public health perspective too, extra pulmonary osteoarticular tuberculosis is not of great importance, because patients with this form of disease are not infectious, unless they have pulmonary involvement. Though WHO protocol short course chemotherapy is a standard recommendation for all countries, it is not being universally followed. Various workers across the world have recommended different duration of chemotherapy for an effective management of spinal Tuberculosis. With the ongoing research in the various aspect of spinal tuberculosis for over 5 decade now, no definite consensus is still achieved for the treatment protocol, like what drug, what regime, what duration of treatment. AIM: To compare the efficacy of WHO regime to conventional treatment (middle path). Method: Between January 2001 till May 2010, 202 cases of newly diagnosed Spinal tuberculosis were included in this prospective study. Of which 88 cases were treated by conventional middle path regime, and 114 cases were treated according to WHO regime (2HRZE+4HR). The average duration of follow up was 4 years (2 – 9 years). Results: Overall incidence was found to be higher in females (56%), with maximum number cases in the age group of 11-40 years, and mean age of presentation being 32 years. Pain was the most common symptom (95%) followed by constitutional symptoms (56%), and abscess (33). Thoracic involvement being more common in males and lumbosacral more common in females. ESR was taken as a useful, was found elevated in 92% cases. Results were evaluated using clinical, haematological, and radiological evidences. MRI used as early diagnostic tool in both the groups and for follow up. All cases treated with middle path regime had good response and showed healing in 85%cases which is statistically highly significant (P value<0.001), whereas short course chemotherapy was found sufficient in 79% cases (P<0.001) , again highly significant. There were no cases of MDR tuberculosis in the conventional treatment group, where as there were 4 cases in the short course chemotherapy group ( non significant).there were no relapse in the two groups. Conclusion: This experience showed medical management is the main stay for treatment in spinal tuberculosis. Patients should be treated as per WHO Short course chemotherapy, but treatment can be suitably extended in cases. 133: Effect of Motor Score on Adverse Events and Quality of Life in Patients with Traumatic Spinal Cord Injury John T Street , BC; Vanessa Noonan, BC; Antoinette Cheung, BC; Brian Sun, BC; Marcel Dvorak, BC Purpose: Neurological impairment associated with traumatic spinal cord injury (tSCI) results in significant health care costs and disability. The purpose of this study was to assess the impact of neurological impairment, specifically motor score on admission with the incidence of adverse events, length of stay (LOS) and long-term health status in patients with tSCI. Method: Patients with a tSCI from one centre were recorded in a prospective registry between 2008 and 2010. Adverse event data was prospectively collected using the Spine Adverse Events Severity instrument. Data related to patients’ injury, diagnoses, hospital admission, and follow-up Short Form-36 (SF-36) Physical and Mental Component Scores (PCS, MCS) were obtained from the Registry. The five most common adverse events were identified and multivariate analyses were performed to determine whether the initial motor score on admission was significantly associated with each adverse event, as well as with LOS and SF36 scores at 1 to 2 years post-injury. Results: 171 patients with tSCI were included, 81.3% were male and the mean age at injury was 47.2±20.3 years. A lower motor score on admission was significantly associated with having pneumonia, pressure ulcers and urinary tract infections (p<0.05); no association was found with delirium or neuropathic pain. There was also a significant association between motor score and the incidence of adverse events and LOS (p<0.0001). For each 10 point decrease in motor score, LOS increased by 20%. In patients with a motor score over 50, the SF-36 PCS increased by 3.8 for each 10 point increase in motor score. There was no effect on the SF-36 MCS. Conclusion: The initial motor score can predict important outcomes such as incidence and type of adverse events, LOS and long-term health status. Patients with low motor scores should be identified on admission to maximize their health outcomes. 134: MRI in Spinal Trauma – A Predictor of Neurological Recovery Rajeshwar Nath Srivastava, IN; Umesh Parasri, IN Purpose: Use of Magnetic Resonance Imaging appears to be of great help in diagnosing spinal trauma & correlating it with clinical profile & neurological outcome because of better contrast resolution, absence of bony artifacts, multiplanar imaging and choice of pulse sequences. In cases of spinal cord ischemia, hemorrhage, edema, and contusion. A study was done to correlate MRI findings with neurological recovery and functional outcome in spinal cord injury Method: We performed this prospective study on sixty two patients of acute spinal trauma. We evaluated the epidemiology of spinal trauma & various traumatic findings by MRI. Then the MRI findings were correlated with clinical findings at admission & discharge according to ASIA impairment scale. Four types of MR signal patterns were seen in association with spinal cord injury- cord edema / non haemmorhagic cord contusion (CC), severe cord compression (SCC), cord hemorrhage (CH) and epidural heamatoma (EH). Isolated lesion of cord contusion was found in 40%. All other MR signal patterns were found to be in combination. In cord contusion we further subdivided the group into contusion of size < 3 cm and contusion of size > 3 cm to evaluate any significance of length of cord contusion. In cord heammorhage involving >1cm of the cord, focus was said to be sizable Results: On bivariate analysis, there was there was a definitive correlation of cord contusion (CC) involving <3cm & > 3cm of cord. In >3cm chances of improvement was 5.75 times lesser than in patients with CC involving <3cm of cord (odds ratio = 5.75 (95% CI: 0.95, 36), Fisher’s exact p = 0.0427 (p<.05). Presence of sizable focus of haemorrhage (HC) in cord (>1cm) was most strongly associated with the poor outcome. The risk of retaining a complete cord injury at the time of follow up for patients who initially had significant haemorrhage in cord was more than 6 folds with patients without initial haemorrhage (odds ratio 6.97 and p= .0047). It was noted that the patients in which epidural hematoma (EH) was present, no improvement was seen, however, by statistical analysis it was not a risk factor and was not related with the outcome (odds ratio – 0.5 and p = 0.22). Presence of severe cord compression (SCC) was a risk factor for poor outcome (odds ratio – 4.90 and p = 0.0143) Conclusion: On multiple logistic regression / multivariate analysis for estimating prognosis, sizable focus of hemorrhage was most consistently associated with poor outcome (odds ratio 6.73 and p= 0.32). In severe cord compression the risk of poor outcome was more (odds ratio 4.3 and p=0.149) however was not statistically significant. Presence of cord oedema / non haemorrhagic contusion was not associated with poor outcome (odds ratio 0.25 and p=0.178) The risk of retaining a complete cord injury at the time of follow up for patients who initially showed evidence of significant haemorrhage in cord was more than 6 folds with patients without initial haemorrhage(Odds ratio – 6.97 and p = 0.0047). 135: No Orthosis is Equivalent to TLSO for the Treatment of Thoracolumbar Burst Fractures Without Neurologic Injury: Results from a Multi-centred RCT Christopher S Bailey, ON; Marcel F Dvorak, BC; Kenneth C Thomas, AB; Melissa Nadeau, ON; Kevin R Gurr, ON; Stewart I Bailey, ON; Charles G Fisher, BC Purpose: To compare the functional outcome of patients with AO type A3 burst fractures randomly treated with a TLSO versus no orthosis (NO). Method: Study design/setting: A multi-centred prospective randomized controlled equivalence trial. Patient sample: Patients were recruited from three Canadian tertiary spine centres. Outcome measures: The primary outcome measure was the Roland Morris Disability Questionnaire (RMDQ) assessed at 3 months post injury. Secondary outcomes were assessed at 2, 6, 12, 24, 52 and 104 weeks and included: pain (Visual Analogue Scale), functional outcome (RMDQ), generic health related quality of life (SF-36), patient satisfaction, sagittal alignment, length of hospital stay and complications. Consecutive patients who satisfied the following inclusion criteria were considered eligible for this study: 1) AO-A3 burst fractures between T11 and L3, 2) skeletally mature and less than sixty years of age, 3) admitted to the participating hospital within seventy-two hours of their injury, 4) initial kyphotic deformity of less then thirty-five degrees, 5) no neurologic deficit. Randomization was stratified according to worker’s compensation status and severity of kyphosis at admission (<20° versus ≥20°). Enrollment continued until the sample size satisfied a power of 90%. The NO group was encouraged to ambulate immediately following randomization with bending restrictions for eight weeks. The TLSO group was weaned from the brace between the eight to ten week period. Both groups were encouraged to perform a standardized physiotherapy routine. Results: 47 patients were enrolled into the TLSO group and 49 patients into the NO group. The mean subject age was 40 years and 70% were male. The majority of fractures occurred at L1 (49) then T12 (18) and L2 (15). At the three month primary endpoint 46 patients were evaluated in each group. There was no difference in average length of hospital stay (TLSO = 4.7 days, NO= 5.0 days). No difference was found between groups for any of the primary or secondary outcomes at any of the follow-up periods (student t-test). One way analysis of variance identified a significant improvement of the RMDQ within both groups at 6 weeks and at 3 months for the NO group (p<0.05) but not afterward. The average kyphotic deformity was 14° (range: -1 to 35) at admission that increased to 21° at 6 weeks and did not progress further. No difference existed between treatment groups. Six patients required surgical stabilization, five of these prior to initial discharge. Conclusion: Neurologically intact thoracolumbar burst fractures can be successfully treated using early ambulation without a brace. 136: Percutaneous Thoracolumbar Stabilization for Trauma: Surgical Morbidity, Clinical Outcomes and Revision Surgery Neil Manson, NB; Renee Elliott, NB; Melissa McKeon, NB; Edward Abraham, NB Purpose: Percutaneous pedicle screw-rod instrumentation (PercStab) without direct decompression or fusion is a surgical option to manage thoracolumbar trauma. The current standard of care includes instrumentation removal following osseoligamentous healing. It is hypothesized that instrumentation removal is not required following PercStab. The purpose of the present study is to evaluate the utility of PercStab in the following areas: 1) patient satisfaction, 2) return of function 3) need for repeat surgery including instrumentation removal or revision decompression and/or fusion procedures. Method: A retrospective review of a prospective database identified patients receiving PercStab for trauma from January 2007 to August 2011. TLICS scoring criteria (Spine Trauma Study Group) identified surgical candidacy. Validated clinical outcome measures, patient demographics, perioperative data, and the need for further surgery were assessed via clinic follow up, chart review, and telephone interview. Medians and ranges were reported. Outcome measures intra-op consisted of OR time/level, EBL/level and intraoperative complications. Post-op complications and LOS were analyzed in addition to VAS back and leg pain scores, Oswestry Disability Index (ODI), Likert-type questionnaire and return to work (RTW) and normal activities. Results: Twenty-six trauma patients with a median Injury Severity Score of 10 (9 – 41) received PercStab to treat spinal instability over two levels (range 1-5) and were contacted for follow-up 24 months (2 months - 4.5 years) post-surgery. Minimal surgical morbidity was incurred: OR time: 36.5 (25 – 63.5) minutes / level, blood loss / level: 40 (12.5 – 250) cc, time post op to hospital discharge: six (1 – 37) days. Patients reported satisfaction: VAS back: 2 (0 – 8), VAS leg: 1 (0 – 7), ODI: 16 (0 – 54), three months (two weeks – six months) to return to work or regular activities. Patients scored a median outcome satisfaction of 5 (3.75 – 5) out of 5 on a likert-type questionnaire. Only 4/26 (15%) of patients required instrumentation removal: two for screw loosening causing back pain and two thin patients for screw prominence causing discomfort with direct pressure. The remaining 22/26 (85%) of patients had no symptoms or complications related to the implants and there was no need for revision surgery for posttraumatic deformity, pseudarthrosis or infection. Conclusion: The PercStab surgical option for spine trauma provides rapid mobilization and discharge from hospital, medium-term satisfaction, with minimal surgical morbidity. The majority of patients returned to work and normal activities on average 3 months post operatively. Instrumentation removal can be considered on an individual basis. No operative procedures were required for post-traumatic deformity, pseudarthrosis or infection. Further research is required to quantify the utility of this technique in comparison to traditional surgical options. 137: Potential of Parathyroid Hormone for Suppressing Calcification in Human Intervertebral Discs and Promoting Repair Padma Madiraju, QC; John Antoniou, QC; Fackson Mwale, QC Purpose: Intervertebral disc (IVD) degeneration is associated with ongoing mineral deposition. The presence of calcium deposits, type X collagen (COL X) and the level of indicators of calcification potential (alkaline phosphatase (ALP), Ca2+ and Pi) are consistently higher in degenerative and scoliotic discs than in control discs. In mesenchymal stem cells parathyroid hormone (PTH 1-34) is able to inhibit the expression of COL X while promoting COL II expression, thereby preventing endochondral ossification. The purpose of this study is to investigate the effect of PTH on the expression of COL II, COL X and ALP in human IVD cells and to elucidate the mechanisms related to its effect. Method: Isolation and culture of IVD cells: Human lumbar IVDs from a donor without spinal pathology were obtained within 24h after death. The procedure was approved by institutional research ethics committee. Nucleus pulposus (NP) and annulus fibrosus (AF) tissues from the IVDs were digested and the corresponding NP and AF primary cells were isolated. These cells were cultured in complete DMEM to 80% to 90% confluence. Then the cells were incubated overnight in serum free medium and treated with 100nM PTH for 30 min to 48h. The cell lysates were prepared and total protein in the cell extracts was determined. Protein expression was analysed by immunoblotting. Western blot images were quantified using ImageJ (NIH) software. The release of Ca2+ into the medium was measured using Calcium assay kit (Cayman Chemicals). ALP activity was measured using the StemTAG kit (Cell Biolabs). Statistical analyses were by One-way ANOVA, post-hoc test. Results: PTH increased the expression of COL II significantly in both AF and NP cells in a time-dependent manner, from 6 to 48h. Expression of COL X was not altered in AF cells, whereas it decreased in NP cells from 6 to 48h. However, the activation of MAPKs occurred much earlier, by 30min incubation with PTH in both cell types. PTH significantly decreased ALP activity by 24h in NP cells, whereas in AF cells no significant changes were observed. PTH caused a significant increase in Ca2+ release by 48h in NP cells but not in AF cells. Conclusion: PTH is known to promote chondrogenesis and inhibit COL X expression in chondrocytes via MAPK activation. The present results demonstrate that PTH up-regulates COL II and down-regulates COL X in IVD cells, indicating that PTH has the potential of being able to stimulate disc repair and improve nutrient supply in the degenerative disc. Our data also suggest that MAPK activation takes place much earlier than the alterations in COL II or COL X expression. Interestingly, COL II expression inversely correlates with ALP activity in NP cells treated with PTH. A thorough understanding of IVD calcification would be of great value, not only for elucidation of its mechanism, but with an eye toward eventual therapeutic intervention. PTH can thus be used towards disc regeneration therapy. 138: Spinal Shock in Spinal Cord Injuries - Is Duration of Shock Related to Neurological Level ? Rajeshwar Nath Srivastava, IN; Sanjeev Arya, IN Purpose: The definition & etiology of spinal shock remain controversial. The factors influencing this duration and its clinical significance are not well studied. A study was undertaken to study the duration and the factors influencing spinal shock.An arithmetical relationship was seen to exist between the duration of spinal shock and the segmental level of spinal cord injury. A study was done to determine the duration of spinal shock in spinal cord injury (SCI), the first reflex to return while recovering from spinal shock & the factors influencing duration of spinal shock Method: 116 patients in spinal shock following SCI were included. A detailed neurological examination of sensory, motor and reflex activity was done everyday till the patients were out of spinal shock. The duration of spinal shock by appearance of any reflex, the first reflex to return & the influence of variable factors on duration of spinal shock were studied Results: In 76 patients (85.4%) anal wink (AW) was the first reflex to return either alone or simultaneous with BC / DPR.In 7 patients cremastric reflex, in 3 pathological reflexes & in 2 deep tendon reflexes ( ankle) were the first to return. Mean duration of spinal shock (MD of SS) was shorter in children, shorter in malnourished, shorter in untrained/laborers, shorter in patients admitted early and shorter in patients without any complications. "MD of SS" was not influenced by sex of patient, associated injuries and by different modalities of treatment Conclusion: On statistical analysis of duration of spinal shock with neurological level as a variable "MD of SS "was 1.7 days in cervical cord lesions, 8.2 days in upper thoracic, 15 days in lower thoracic and 17 days in lumbar cord lesions. Such an arithmetical progression was also found at each segmental level i.e. the duration of spinal shock progressively increased at every segmental level. "MD of SS" was 1.36days at C4, 1.60 at C5, 1.72 at C6, 8.1 at T6, 12.4 at T8, 13.1 at T10, 15.3 at T12 & 21.6 at L2. An arithmetical relationship exist between the duration of spinal shock and the segmental level of spinal cord injury - the duration of spinal shock was directly proportional to level of injury. Higher or proximal the lesion, shorter is the duration. We do not have the answer of this important observation. Does the duration of spinal shock dependant on the cord length / neuronal mass involved / spared? 139: The Effect of Timing to Decompression in Cauda Equina Syndrome Using a Rat Model Christopher S Bailey, ON; R Andrew Glennie, ON; Jennifer Fleming, ON; Kevin R Gurr, ON; Stuart Bailey, ON; David Sanders, ON; Abdel R Lawendy, ON Purpose: Cauda Equina syndrome is a devastating injury for which surgery is the only treatment option, however, controversy exists regarding the optimal timing of surgery. Clinical studies have investigated the effect of the timing of surgical decompression for motor recovery, but no definitive recommendations exist. The effect on bladder function and sensation has been sparsely investigated. The purpose of this study was to determine the effect of duration of extra-dural cauda equina compression on bladder, sensory, and motor dysfunction using a rat model. Method: Under general anesthesia a balloon-tipped Fogerty catheter (2 mm diameter) was inserted underneath the 5th and 6th lumbar vertebral bodies and inflated to rapidly compress the cauda equina. A three-way stopcock allowed pressure monitoring to ensure consistent extra-dural compression of 250 mmHg. The compression was maintained for 1 h or 4 h at which time the balloon was deflated, representing surgical decompression. Sham animals had the catheter inserted underneath the vertebral bodies, but the catheter was not inflated. Over a four week period pain scores, urinary residual volumes, and locomotor function were assessed. Post mortem, bladders and kidneys were collected for analysis. Results: Final bladder pressure and bladder weights were greater in the 4h compression group versus the 1 h compression group (p<0.05). Pain scores were greater for 1 hr CES rats and remained consistently elevated to the end of the protocol. The locomotion data could not detect a difference gait coordination between all groups. Conclusion: Our data suggest that motor function after urgent or delayed decompression will likely lead to full recovery. Bladder functional recovery is much less predictable and seems to be very sensitive to longer durations of compression. This has significant implications on patients presenting with acute cauda equina syndrome and how to proceed if these symptoms are identified. 140: Use of the Spine Adverse Events Severity (SAVES) Instrument for Traumatic Spinal Cord Injury John T Street, BC; Vanessa Noonan, BC; Antoinette Cheung, BC; Brian Sun, BC; Marcel Dvorak, BC Purpose: Adverse events are common during the acute phase of care in patients with traumatic spinal cord injury (tSCI). Administrative data is often used to report adverse events however this data may not reflect patient outcomes. The Spine Adverse Events Severity (SAVES) instrument was developed for clinicians to record adverse events. The objective of this study was to determine if the SAVES was superior to ICD-10 codes in measuring adverse events in patients with tSCI. Method: Patients discharged between 2006 and 2010 were identified from a prospective registry. Two cohorts were created based on the method used to record adverse events; Cohort 1 used ICD-10 codes and Cohort 2 used SAVES data. The ICD-10 codes were mapped to adverse events in SAVES. Five adverse events were examined: neuropathic pain, urinary tract infections (UTI), pneumonia, pressure ulcers and delirium. There were 212 patients in Cohort 1 and 173 patients in Cohort 2. Analyses were adjusted to account for the different sample sizes and the two cohorts were comparable based on age, gender, mechanism of injury and motor score. Results: There was an 18% increase in the number of patients diagnosed as having one or more adverse events using SAVES (76%) compared to ICD-10 codes (58%). The number of adverse events per person more than doubled using SAVES (1.3 versus 2.7). The SAVES reported greater incidence of neuropathic pain (x32), UTI (x1.4), pneumonia (x1.2), pressure ulcers (x2.9) and delirium (x1.2). The number of intra-operative adverse events obtained was 2.3 times greater using SAVES (7.5% versus 17.3%). Conclusion: The implementation of SAVES among patients with tSCI captured more patients experiencing adverse events and more adverse events per person compared to using ICD-10 codes. This study demonstrates the value of prospectively collecting data on adverse events. 141: Ability of Pre-Season Body Composition & Physical Fitness to Predict Risk of Injury in Male Collegiate Hockey Players John A Grant, US; Asheesh Bedi, US; Jennifer Kurz, US; Richard Bancroft, US; Joel J Gagnier, US; Bruce S Miller, US Purpose: Injuries in collegiate ice hockey can result in significant time lost from play. On average, the combined lost time for all players injured in one year is equal to the loss of one player for almost the complete season. The identification of modifiable risk factors relating to a player’s physical fitness allows the development of focused training and injury prevention programs targeted at reducing these risks. No studies have evaluated the risk of on-ice injury relative to modifiable risk factors such as a player’s conditioning level, strength and/or body composition. The purpose of this study was to determine the injury rate for male collegiate ice hockey and determine the role of pre-season fitness measures in predicting an on-ice injury. Method: A case control study was performed using data prospectively collected by one male collegiate ice hockey team over the past 8 seasons. There were 79 different players and 203 player-years. Athlete demographics, percent body fat), aerobic endurance (300m shuttle run; 1, 1.5, 5 mile run), and strength assessment (sit-ups, push-ups, grip strength, bench press, Olympic cleans, squats) data was collected at the beginning of each season. Detailed hockeyrelated injury data and player-level practice/game athlete exposure (AE) data was collected and entered by the team Athletic Trainer. Injury was defined as any event that resulted in the athlete being unable to participate in one or more practices or games following the event. Descriptive statistics were performed. Single and multiple variable logistic regression was performed to determine the ability of the independent variables to predict the risk of on-ice injury. Given that athletes played multiple years, “athlete” and “year” interaction variables were entered into the models. Results: There were a total of 132 injuries (mean 16.5 per year, range 12-21). The overall injury rate was 4.4 injuries per 1000 AE (yearly range 3.2-6.1/1000 AE). Forwards suffered 68% of injuries. Seventy percent of injuries occurred during games with equal distribution between the three periods. The mean number of days lost due to injury was 10.8±21.6 (range 1-135). The thigh/hip (21%) and shoulder (20%) were the most common body areas of injury. The most common mechanism of injury was contact with another player (60%). The odds of injury in a forward was 1.9x that of a defence and 3.0x that of a goalie. The odds of injury if the player’s BMI was ≥25 was 2x that of a player with a BMI <25. The odds of injury increased by 2.7x for each increase of 5% body fat. There were no strong predictors of injury amongst the aerobic and strength variables. Conclusion: Forwards have a higher odds of injury relative to other player positions. BMI and percent body fat were predictive of on-ice injury. Aerobic fitness and maximum strength outcomes were not strongly predictive of on-ice injury. The use of more sport specific aerobic/strength measures should be evaluated for their ability to predict injury. 142: Arthroscopic and Magnetic Resonance Imaging (MRI) Grading of Articular Cartilage Lesions of the Knee: Inter-rater Reliability and Reliability Between Modalities Randy Mascarenhas, MB; Eric J Kropf, US; Charity G Moore, US; Joanna Costello, US; Peter B MacDonald, MB; Constance R Chu, US; Christopher D Harner, US; James J Irrgang, US Purpose: The purpose of this study was to determine inter-rater agreement for identification and grading of cartilage lesions in the knee by arthroscopy and magnetic resonance imaging (MRI). Method: De-identified videos and corresponding MRI from 21 patients were randomized and shown to 4 surgeons and 3 radiologists. Videos and MRI were graded in a blinded manner. Lesions were identified and graded for 9 regions on the femoral condyle and 5 regions on the tibial plateau using the modified ICRS grading scale. Kendall’s coefficient of concordance (Kendall’s W) was calculated to determine agreement amongst surgeons, amongst radiologists and between surgeons and radiologists. Results: Inter-rater agreement amongst surgeons was highest in the central-central zone on the femoral condyle (W=.80) and the non-meniscus weight-bearing zone on the tibial plateau (W=.64). Amongst radiologists, inter-rater agreement was highest for the central-central zone on the femoral condyle (W=.67) and the anterior meniscus zone on the tibial plateau (W=.64). The highest agreement between arthroscopic and MRI grading was found for the centralcentral zone on the femoral condyle (W=.66) and the non-meniscus weight bearing zone on the tibial plateau (W=.49). In general, agreement between arthroscopic and MRI grading was higher for the femoral condyle than for the tibial plateau. Conclusion: Fair agreement was seen between arthroscopic and MRI grading of articular cartilage lesions. Inter-rater agreement was highest for centrally located femoral and tibial lesions and lowest for peripheral femoral lesions. Cartilage-sensitive MRI sequences may be required for more accurate diagnosis and grading of articular cartilage lesions. 143: Correlation of WOMAC/KOOS Scores to Cartilage Loss on 3T MRI and Plane Radiography: Data from the Osteoarthritis Initiative (A Prospective Multicenter Study) Kenneth David Illingworth, US; Youssef El Bitar, US; Kyle Siewert, US; Steven Scaife, US; Khaled Saleh, US Purpose: Subjective patient scores have been used as measuring parameters for patient function as well as outcome assessments after knee surgery. Two of the most common subjective scores used are the Knee Injury Osteoarthritis Outcomes Score (KOOS) and the Western Ontario and McMaster Universities Osteoarthritis Index Scores (WOMAC). The purpose of this study was to determine the correlation between these subject scores and the degree of cartilage loss on 3 Tesla MRI and plane radiography. Our hypothesis is that an increase in cartilage loss will be associated with decreasing patient scores indicating greater pain and dysfunction. Method: Data used in the preparation of this article were obtained from the Osteoarthritis Initiative (OAI) database (OAI public use data sets kMRI_QCart_Eckstein18 and kXR_QJSW_Duryea16). Of the 906 patients at baseline with 3Tesla MRI, 497 patients were identified that had documented WOMAC/KOOS scores, quantitative cartilage data on 3T MRI and baseline posterior anterior flexion weight bearing plane radiographs. Each patient at baseline took the KOOS function, sports and recreational activities score, KOOS Pain score, KOOS quality of life score, KOOS symptom score, WOMAC disability score, WOMAC pain score, WOMAC stiffness score and WOMAC total score questionnaires. Each subjective score was correlated to the degree of cartilage loss on 3T MRI, as assessed by percentage of tibiofemoral subchondral bone denuded of cartilage, and degree of joint space narrowing on plane radiographs using Pearson correlation coefficients with a statistical significance of p < 0.05. Results: The KOOS symptom score had a statistically significant correlation to subchondral bone denuded of cartilage at all 10 areas of the tibia and all 6 areas of the femur with an average correlation of r = -0.17, p < 0.05. The highest KOOS symptom score correlation was in the external medial tibia (r = -0.25, p < 0.05) for the tibia and in the central medial femoral condyle (r = -0.25, p < 0.05) for the femur. The only other score to have a significant correlation greater than r = -0.20 was the KOOS pain score in the external medial tibia. No WOMAC score had a correlation greater that r = -0.20. Similar findings were noted for the correlation of joint space loss on plan radiography, with the KOOS symptom score having the highest correlation (r = 0.20). Conclusion: The highest significant correlation was found between the KOOS symptom score and cartilage loss on 3 Tesla MRI and joint space width on plane radiographs, although the correlations were weak in all areas. These patient subject scores have been heavily utilized as tools for patient assessment of knee osteoarthritis, dysfunction and outcomes. However, these scores only weakly correlate with the degree of cartilage loss in the tibiofemoral joint and therefore further emphasize the fact that pain, dysfunction and OA is a multifactorial process. 144: Does Ligament Preservation During Anterior Cruciate Ligament (ACL) Reconstructive Surgery in ACL Deficient Patients Improve Patient-reported Outcomes at One-year? A Prospective Cohort Study Nicholas GH Mohtadi, AB; Denise S Chan, AB; Rhamona S Humphrey, AB; Alexandra Naylor, AB Purpose: To prospectively compare the disease-specific quality of life and clinical outcomes of patients who had ACL reconstructive surgery with ligament preservation using a hamstring tendon autograft to patients who underwent a standard ACL reconstruction at one year. Method: This prospective cohort study compared two groups of ACL deficient patients undergoing ACL reconstruction. Group 1 (Preserved) had a preserved ACL and 2-stranded semitendinosus autograft reconstruction (n=43; 19 males, 24 females; mean 30.1 years; 20 acute); Group 2 (Standard HT) had a standard 4-stranded semitendinosus and gracilis autograft reconstruction (n=43; 24 males, 19 females; mean 30.3 years; 16 acute). The ACL preservation technique was indicated and performed in ACL deficient patients with mild to moderate translation and rotational abnormalities under anesthesia, and arthroscopic evidence of robust ACL tissue. At the time of reconstruction, the 2-stranded semitendinosus graft was placed around or through preserved ACL tissue. Group 2 were matched based on age, gender and acuity. All patients had identical fixation and surgical technique. The primary outcome was the disease-specific, patient-reported ACL Quality of Life (ACL-QOL). Secondary outcomes included the subjective and objective IKDC scores, KT Arthrometer measurements and the pivot shift. An independent trained research coordinator measured the clinical outcomes. Results: Matching the patients for age, gender and acuity was effective and showed no difference between groups. Baseline ACL-QOL, IKDC scores, pivot shift and KT arthrometer measurements were not statistically different. Mean one-year ACL-QOL scores approached statistical significance, with 80.4 (SD=17.2; 95% CI=74.9-85.8) for the Preserved and 72.7 (SD=21.2; 95% CI=66.2-79.3) for the Standard HT, p=0.076. However, accounting for baseline scores revealed a statistically significant change in ACL-QOL and subjective IKDC scores from baseline to one year between the groups (p=0.026 and p=0.029, respectively). At one year, mean objective IKDC scores were statistically different: 84% (36/43) of the Preserved and 74% (32/43) of the Standard HT group had Normal or Nearly Normal knees (p=0.048). The proportion of patients with a positive pivot shift at one year was not different between groups (p=0.245). The mean side to side difference on the KT arthrometer (30lbs) was significantly more stable for the Preserved (2.0mm, SD=1.5mm; 95% CI=1.4-2.5mm) compared to the Standard HT (2.8mm; SD=1.8mm; 95% CI=2.2-3.4mm), p=0.030. Conclusion: ACL preservation using a 2-stranded hamstring autograft results in better quality of life, improved objective stability (KT arthrometer) and overall IKDC score with a higher percentage of normal and nearly normal knees at one year compared to standard 4-stranded hamstring tendon reconstruction. The clinical relevance of this study suggests that in 10-15% of ACL deficient patients, a double stranded semitendinosus ACL preservation technique should be considered. 145: Long-term Follow-up of ACL Reconstruction: Insight into the Natural History of Altered Biomechanics of the Knee Joint Jeffrey RS Leiter, MB; Robert Gourlay, MB; Sheila McRae, MB; Nevin de Korompay, MB; Peter B MacDonald, MB Purpose: The goal of anterior cruciate ligament (ACL) reconstruction is to restore knee stability and prevent onset of osteoarthritis(OA). Little is known of the long-term natural history of a knee joint that has undergone ACL reconstruction. The purpose of our study is to investigate long-term changes in the knee joint following ACL reconstruction with respect to OA, joint space narrowing, knee laxity, activity level, strength and quality of life. Hypothesis: There will be no differences in the incidence and severity of knee OA, joint space narrowing, knee laxity, activity level, quality of life, and knee flexion and extension strength between an ACL reconstructed knee and the contralateral non-reconstructed (control) limb of study participants. Method: Study Design: Retrospective Case Series. The surgical database of the senior author (PM) was searched to identify patients that had a semitendinosus/gracilis (ST) graft ACL reconstruction and were more than 12 years post operative. Patients were contacted via phone or mail and invited to participate. Clinical evaluation involved radiographic analysis, IKDC, KT1000, Tegner Activity Scale, Lysholm Knee Score, ACL-QOL , and knee flexor/extensor strength testing using the Biodex III dynamometer. Results: Sixty-eight (43 males, 25 female) participants consented to the study. Average age (SD) at time of surgery was 31.2 (±9.1) years. At a mean follow-up of 14.6 (1.9) years postoperative, 7% of participants had re-ruptured their ACL whereas 6% ruptured their contralateral ACL. Reconstructed knees presented with increased arthritic changes than the contralateral side (p=0.001). Medial meniscal surgery (repair or partial menisectomy) was a strong predictor of OA. There was no clinically significant difference in KT-1000 scores between reconstructed and non-reconstructed knees. Seventy-five percent of participants scored a normal or nearly normal knee on the IKDC. The mean Lysholm score was 75.8% and Tegner Activity Level scores decreased significantly (0.001) from the time of surgery. Knee extension strength was greater in the non reconstructed knee at speeds of 60-(p=0.014) and 150-deg/s(p=.012). There was no difference in knee flexion strength at any speed. Conclusion: Reconstructed knees have increased OA changes compared to nonreconstructed knees and medial meniscal surgery is a strong predictor of OA. Despite this, 75% of patients reported good outcomes at greater than 12 year follow-up. This study provides insight into the long-term natural history of ACL reconstuction which is imperative to develop techniques and programs aimed at preventing, or delaying the onset of OA. 146: Managing Knee Osteoarthritis: The Effects of Body Weight Supported Activity on Joint Pain and Physical Function Mathew Christian, MB; Jason Peeler, MB; Jeffrey RS Leiter, MB; Peter B MacDonald, MB Purpose: Knee osteoarthritis (OA) is a degenerative joint condition characterized by progressive joint pain, swelling, and loss of muscle and joint function for which there is no known cure. Current research indicates that the most important modifiable risk factor for the development and progression of knee OA is obesity, a condition that is increasingly common in older adults. Contemporary exercise programs aimed to initiate weight loss and improve knee OA symptoms involve activities that increase joint loading, which is a risk factor for further joint degradation and disease progression. Using a new anti-gravity treadmill, capable of generating a lifting force using differential air pressure (DAP), patients with knee OA can engage in regular physical activity while minimizing joint loading. The aim of this study was to assess the effect of a 12-week, anti-gravity treadmill walking program on knee pain and function in obese older adults with knee OA. Method: Participants between ages 55-75, with a body mass index (BMI) ≥ 25 kg/m2, and symptomatic knee OA were recruited. Data from a preliminary safety analysis is presented for 13 participants, with a mean (SD) age of 60.2 (5.6) years and BMI of 35.5 (7.7) kg/m2. Over a 12 week period, participants exercised twice weekly on an anti-gravity treadmill at a percentage of body weight that minimized knee pain while walking. Knee symptoms and function (Knee injury and Osteoarthritis Outcome Score (KOOS), knee pain during full weightbearing treadmill walking (FTW), cardiovascular fitness (YMCA submaximal cycle ergometer test), and activity level (average daily pedometer readings) were assessed at baseline and following the completion of the 12-week program using paired t-tests (α = 0.05). Results: Improvements between baseline and outtake were found in all KOOS subscales (Pain: p=0.023; Symptoms: p=0.001; Activities of Daily Living: p=0.045; Sport & Recreation: p=0.050; Quality of Life: p=0.0002). Knee pain during FTW decreased (p=0.0048). Cardiovascular fitness (p=0.011) and average daily pedometer readings (p=0.006) were also increased. Conclusion: Preliminary results of this study suggest that anti-gravity treadmill walking improves knee pain and function during full weight bearing daily activities, including full weightbearing treadmill walking. Cardiovascular fitness and daily activity levels also improved. These findings suggest that anti-gravity treadmill technology has the potential to improve the overall health and functional autonomy of at-risk individuals, and advance current methods of rehabilitation and long term management of chronic symptomatic knee OA. 147: Measuring the Anterior Cruciate Ligament’s Footprints by Three-dimensional Magnetic Resonance Imaging Adam Hart, QC; Yung Han, QC; David Kurzencwyg, QC; Tom Powell, QC; Paul A Martineau, QC Purpose: The purpose of this study was to compare three-dimensional magnetic resonance (3D MR) imaging with open cadaveric measurements of the anterior cruciate ligament’s (ACL) footprint in order to see whether the scanned images are accurate enough to be used for preoperative templating in anatomic ACL reconstruction. Method: Eight formalin-injected cadaveric knees were scanned by rapid acquisition isotropic 3D MR imaging. The femoral and tibial footprints were measured on MR imaging and compared with cadaveric dissection. Bland–Altman plots were used to assess the level of agreement. Results: The anteromedial (AM) and posterolateral (PL) fibre bundles were clearly appreciated in each specimen by 3D MR imaging and cadaveric dissection. The average paired difference in the femoral and tibial footprint measurements was two, one, two, and two millimetres for the femoral footprint length, femoral footprint width, tibial footprint length, and tibial footprint width, respectively. The individual paired measurements were all within the mean difference ± two standard deviations of the difference in the Bland–Altman plot showing strong agreement. Conclusion: Measuring the ACL’s footprint by 3D MR imaging or open cadaveric dissection has strong agreement and can be used interchangeably. Three-Dimensional MR imaging has the potential to allow surgeons to: (1) tailor ACL reconstruction technique or graft choice based on ACL footprint size, (2) plan for selective bundle ACL reconstruction for partial tears, and (3) preoperatively template tunnel position according to the patient’s individual anatomy. 148: Meniscus Surgery and Cartilage Loss on 3T MRI: Data from the Osteoarthritis Initiative (A Prospective Multicenter Study) Kenneth David Illingworth, US; Matthew Lovell, US; Evan Armington, US; Steven Scaife, US; Ryan Combs, US; Saadiq El-Amin, US; Khaled Saleh, US Purpose: A history of previous meniscus injury or meniscectomy has been shown to be associated with an increased incidence of knee osteoarthritis as hypothesized to be caused by altered tibiofemoral knee kinematics with a shift in contact wear patterns. The purpose of this study was to look at the effect of previous meniscus surgery on tibiofemoral joint cartilage wear patterns as assessed by 3 Tesla magnetic resonance imaging. Our hypothesis is that individuals with a history of meniscus surgery will have increased tibiofemoral osteoarthritis as well as have specific wear patterns on the tibia and femur. Method: Data used in the preparation of this article were obtained from the Osteoarthritis Initiative (OAI) database (OAI public use data set kMRI_QCart_Eckstein18). Of the 906 patients at baseline with 3 Tesla magnetic resonance imaging and documented quantitative cartilage data, 61 patients had a previous history of meniscus surgery and 667 control patients had no history of meniscus surgery. All patients with a previous history of knee surgery, other than meniscus surgery, were excluded. The percentage of subchondral bone denuded of cartilage and minimum cartilage thickness in six femoral and ten tibial regions was quantified for each patient. Each patient took the KOOS function, sports and recreational activities score, KOOS Pain score, KOOS quality of life score, KOOS symptom score, WOMAC disability score, WOMAC pain score, WOMAC stiffness score and WOMAC total score questionnaires. Independent T-tests with a significance of p < 0.05 were used for group comparisons. Results: There was a statistically significant increase in subchondral bone denuded of cartilage in all tibial regions and in the medial femoral condyle in patients with a history of meniscus surgery (p < 0.05). The largest mean differences between groups were found in the external medial femoral condyle and central medial femoral condyle, and the external medial tibia and posterior medial tibial regions. There was a statistically significant decrease in mean cartilage thickness in the external medial tibia, internal lateral tibia, posterior lateral tibia, external medial femoral condyle and central medial condyle in patients with a history of meniscus surgery (p < 0.05). Patients with a history of meniscus surgery had a statistically significant worse subjective KOOS and WOMAC scores in all areas when compared to no history of meniscus surgery (p < 0.05). Conclusion: Patients with a history of meniscus surgery have decreased cartilage in both the medial and lateral tibiofemoral compartments as assessed on 3 Tesla MRI, with a more pronounced decrease in cartilage being found in the medial compartment. Patients with a history of meniscus surgery have increased pain and decreased function as shown with the KOOS and WOMAC scores in this study. 149: Meniscus Surgery and Joint Space Width Narrowing on Plane Radiographs: Data from the Osteoarthritis Initiative (A Prospective Multicenter Study) Kenneth David Illingworth, US; Evan Armington, US; Matthew Lovell, US; Steven Scaife, US; Ryan Combs, US; Saadiq El-Amin, US; Khaled Saleh, US Purpose: A history of previous meniscus injury or meniscectomy has been shown to be associated with an increased incidence of knee osteoarthritis due to alterations in knee kinematics and contact wear patterns. The purpose of this study was to evaluate posterior to anterior flexion weight bearing radiographs of patients with a previous history of meniscus surgery in one knee and compare this with the contralateral knee with no previous surgery. Our hypothesis is that the knee with the history of meniscus surgery will have more significant quantifiable tibiofemoral joint space narrowing. Also the degree of joint space narrowing will be correlated to how far out the individuals are from surgery. Method: Data used in the preparation of this article were obtained from the Osteoarthritis Initiative (OAI) public use data set (kXR_QJSW_Duryea16). Of the 1,805 patients with joint space width quantified, 187 individuals had a positive history of previous meniscus surgery on one knee with no history of surgery on their contralateral knee. All individuals had standing flexion weight bearing posterior to anterior x-rays. Joint space width narrowing was analyzed at 16 locations in the tibiofemoral joint, with 7 locations in the medial compartment and 9 locations in the lateral compartment. Time from surgery was recorded for each individual. Independent T-tests were used for comparison between individual’s knees. Results: Mean time from surgery for the 187 individuals was 12.99 +/- 13.5 years. The mean decrease in medial and lateral joint space in knees with previous meniscus surgery compared to no history of meniscus surgery was 0.94 mm and 0.48 mm, respectively. There was a statistically significant decrease in joint space width in all 7 measurements of the medial compartment in the meniscus knee group (p < 0.001). There was also a statistically significant decrease in joint space width in the most medial measurement of the lateral compartment in the meniscus knee group (p < 0.001), with no statistically significant difference being found between the remainder of the lateral joint space measurements between knees. Conclusion: Patients with a history of meniscus surgery are more like to have a decrease in tibiofemoral joint space width on posterior to anterior x-rays, with a larger decrease being found in the medial compartment. 150: Poor Agreement Amongst Surgeons Arthroscopically Evaluating Anterior Cruciate Ligament Tunnel Placement Mark O McConkey, BC; Annuziato Amendola, US; MOON Group, US; Brian R Wolf, US Purpose: To evaluate the agreement on ACL tunnel position between performing surgeon and independent evaluating surgeons using arthroscopic assessment. Our hypothesis is that the performing and evaluating surgeons would characterize the tunnel positions significantly differently. Method: Twelve experienced knee surgeons performed six ACL reconstructions each on a total of 72 cadavers. Four surgeons each performed trans-tibial (TT), medial portal (MP), and two-incision techniques (2I) for femoral drilling. They drilled tibial and femoral tunnels using their standard technique. Subsequently, they completed a form to document their assessment of tibial and femoral tunnel placement. Back wall thickness was judged ideal, too thick or too thin. Femoral tunnel position was estimated using clock-face technique and overall position was deemed ideal, too vertical, too horizontal, too anterior or too posterior. Tibial tunnel apertures were judged ideal, too anterior, too posterior, too medial or too lateral. Femoral and tibial tunnels were then noted to be acceptable or unacceptable. Three independent surgeon reviewers examined each knee and filled out the same form documenting tunnel position. Statistics were performed to compare tunnel position judgment of performing and evaluating surgeons and tunnel placement was compared to surgical technique. Agreement between surgeons was analyzed with Kappa values. Results: Differences between surgeon and independent evaluations were found to be significant. The surgeon would more likely judge his femoral tunnel position (92.65% vs 70.00%; p=0.0054) and wall thickness (93.94% vs 74.24%; p=0.0004) ideal compared to an observer. Surgeons also judged tunnels acceptable significantly more often (98.48% vs 82.32%; p=0.0009). Observers’ assessments of femoral tunnel position were analyzed based on surgical technique. Tunnels were more likely to be judged ideal when 2I technique was used compared to MP and TT (86.96% vs 66.67% vs 51.67%; p<0.0001). Tibial tunnel positions had similar findings with the surgeon more likely to deem his tunnel ideal (95.59% vs 58.10%; p<0.0001); observers judged the tunnels too posterior in 29.52% of cases. When asked if tunnels were acceptable or unacceptable surgeons and observers differed (100% vs 89.89% acceptable; p=0.0052). Tunnel positions differed significantly based on technique again: MP 68.12%, 2I 62.32%, and TT 38.33% were ideal (p=0.0002). When TT technique was used 53.33% of tunnels were judged too posterior.Agreement amongst surgeons and observers was overall poor for each parameter with Kappa values ranging from -0.0053 to 0.2457. Conclusion: Surgeons are more likely to judge tunnels they drilled ideal and acceptable than observers. TT technique yields more poorly positioned tunnels than 2I or MP techniques when judged arthroscopically. Overall agreement on tunnel position was poor amongst the surgeons especially for clock-face technique. Surgeons do not agree on the ideal placement for single bundle ACL tunnels. 151: Clinical Outcomes of Fractures of the Distal Radius in Men Under the Age of 50 Geoffrey Johnston SK Purpose: To document the process of clinical recovery and treatment outcomes of distal radial fractures in men under the age of 50. Method: The outcome measures included the patient rated wrist evaluation (PRWE), and the percentage of active dorsiflexion, palmarflexion, supination, pronation, and grip strength (GS) compared to the uninjured opposite arm. These were assessed at nine weeks, three, six and 12 months post-fracture. Data for dominant and non-dominant limbs were pooled. Results: Ninety-five men 20 - 49 years old were evaluated, for up to one year after their distal radial fracture. Of these 95 fractures 50 (53%) involved the non-dominant, and 45 (47%) the dominant arm. Fifty-three patients were treated non-operatively, 42 operatively.The mean x-ray values in the non-operative and operative groups, respectively, at 3 months were: radial inclination of 23 degrees and 25 degrees, positive ulnar variance of 1.5 in both, and dorsal tilt of 1 degree and volar tilt of 2 degrees, In the non-operative group at 9 weeks post-fracture 27 (51%) completed the PRWE, 19 (45%) from the operative group. Mean PRWE scores were 46 for the non-operative group and 65 for the operative group. Mean DF, PF, supination and pronation values were 79%, 73%, 81% and 91%, and 58%, 63%, 75% and 93% for the non- operative and operative groups, respectively. GS averaged 47% and 38% for the nonoperative and operative sides, respectively. In the non-operative group at 3 months postfracture 25 (47%) completed the PRWE, and 19 (45%) from the operative group. Mean PRWE scores were 35 for the non-operative group and 46 for the operative group. Mean DF, PF, supination and pronation values were 85%, 79%, 81% and 95%, and 67%, 65%, 83% and 95% respectively for the non-operative and operative groups, respectively. GS averaged 57% and 48% for the non-operative and operative sides, respectively. In the non-operative group at 6 months post-fracture 12 (23%) completed the PRWE, and 13 (31%) from the operative group. Mean PRWE scores were 17 for the non-operative group and 37 for the operative group. Mean DF, PF, supination and pronation values were 97%, 87%, 90% and 97%, and 80%, 80%, 97% and 95% for the non-operative and operative groups, respectively. GS averaged 70% and 69% for the non-operative and operative sides, respectively. In the nonoperative group at 12 months post-fracture 4 (8%) completed the PRWE, and 10 (24%) from the operative group. Mean PRWE scores were 5 for the non-operative group and 27 for the operative group. Mean DF, PF, supination and pronation values were 100%, 78%, 91% and 97%, and 83%, 77%, 90% and 98% for the non-operative and operative groups, respectively. GS averaged 87% and 78% for the non-operative and operative sides, respectively. Conclusion: Although motion was restored early, recovery from a distal radial fracture in this young population, as reported by the patient and by grip strength, may take at least a year to rival the uninjured side. 152: Effects of Regional Anaesthesia (RA) versus General Anaesthesia (GA) on Outcomes of Distal Radius Open Reduction and Internal Fixation (ORIF) Henry Broekhuyse, BC; Sebastian Jonathan Ko, BC; Calvin Wang, BC; Robert Petretta, BC Purpose: The purpose of this study was to determine what effect the type of anaesthesia might have on early clinical and functional outcomes following ORIF of distal radius fractures. Method: We performed a retrospective review of patient data obtained from a prospectively collected database of patients treated for distal radius fractures at a Level 1 Trauma centre. A total of 503 distal radius fractures were treated surgically from November 2004 to February 2011. Inclusion criteria were (1) distal radius fracture treated with ORIF; (2) received GA alone, RA alone, or RA + GA; (3) at least 1 year of post-surgical followup. Exclusion criteria were (1) patients treated with external fixation or percutaneous pinning; (2) presence of other ipsilateral upper extremity injuries, (3) other significant injuries requiring operative intervention. A total of 445 patients were included, 263 pts (n=263) in group 1 (GA), and 182 pts (n=182) in group 2 (RA +/- GA). At 3, 6 and 12 months post-op, patients were evaluated (1) objectively by the physiotherapists on ROM, grip and pinch strength, and (2) subjectively by the DASH, PRWE, and SF-36 functional outcome questionnaires. Results: There was no difference in patient demographics between the groups, except for a statistically significant increased anaesthesia time (p<0.000001) for the RA group (34 mins) compared to the GA group (28 mins), and a higher baseline SF-36 physical component summary score (p=0.029). At 3 months, the GA group demonstrated better wrist flexion (compared to the contralateral non-injured side) by 7% (p=0.031), grip strength by 12% (p=0.017), and pinch strength by 12% (p=0.022). The RA group had improved wrist extension at 6 months, although this was not statistically significant. At 12 months, wrist supination was improved by 3.1% in the RA group (p=0.049). No difference was found in grip or pinch strength at 6 and 12 months. With regards to functional outcome scores, the RA group tended to have better DASH scores at 3, 6, and 12 months, but this was not statistically significant. At 3 months, there was no difference in PRWE scores between the two groups. At 6 months, the RA group had statistically significant lower disability on the PRWE pain subscore (p=0.052) and total score (p=0.055). The RA group tended to have better PRWE subscores at 12 months, but this was not statistically significant. There was no difference in SF-36 scores between the two groups at any time interval. Conclusion: This study suggests that patients receiving general anaesthesia have improved wrist motion and strength at 3 months, when compared with patients receiving regional anaesthesia. Patients receiving regional anaesthesia may have improved functional outcomes compared with patients receiving general anaesthesia, although this was not statistically significant at all time intervals. Effects of the choice of anaesthesia on both clinical and functional patient outcomes appear to be diminished with longer follow-up intervals. 153: External Fixation versus Open Reduction with Plate Fixation for Distal Radius Fractures: A Meta-analysis of Randomized Controlled Trials Paul RT Kuzyk, ON; John Esposito, AB; Michel Saccone, ON; Emil H Schemitsch, ON Purpose: Both external fixation and open reduction with internal fixation (ORIF) using plates have been recommended for treatment of distal radius fractures. We conducted a systematic review and meta-analysis of randomized controlled trials comparing external fixation to ORIF with plate fixation. Method: MEDLINE, EMBASE, and COCHRANE databases were searched from inception to January 2011 for all trials involving use of ORIF with plate fixation and external fixation for distal radius fractures. Eligibility for inclusion in the review was: use of random allocation of treatments; treatment arm receiving external fixation; and treatment arm receiving ORIF with plate fixation. Eligible studies were obtained and read in full by two co-authors who then independently applied the Checklist to Evaluate a Report of a Nonpharmacological Trial. Pooled mean differences were calculated for the following continuous outcomes: wrist range of motion; radiographic parameters; grip strength; and Disabilities of the Arm, Shoulder, and Hand (DASH) score. Pooled risk ratios were calculated for rates of complications and reoperation. Results: The literature search strategy identified 52 potential publications of which nine publications (10 studies) met inclusion criteria. The pooled mean difference for DASH scores was significantly less for the ORIF with plate fixation group (-5.92, 95% C.I. of -9.89 to -1.96, p<0.01, I2=39%). The pooled mean difference for ulnar variance was significantly less in the ORIF with plate fixation group (-0.70, 95% C.I. of -1.20 to -0.19, P=0.006, I2=0%), indicating better restoration of radial length for this group. The pooled risk ratio for infection was 0.37 (95% C.I. of 0.19 to 0.73, P=0.004, I2=0%), favouring ORIF with plate fixation. There were no significant differences in all other clinical outcomes. Pooled data for most outcomes was improved by including data from the four studies using volar plates exclusively. Conclusion: ORIF with plate fixation provides lower DASH scores, better restoration of radial length and reduced infection rates as compared to external fixation for treatment of distal radius fractures. 154: Fractures of the Distal Radius in Women in Middle and Older Adulthood: The CAST Trial - Preliminary Results of a Randomised Pilot Study Charlene Magnus, SK; Geoffrey Johnston, SK; Catherine Arnold, SK; Vanina Dal Bello-Haas, SK; Jenny Basran, SK; Joel Krentz, SK; Jonathan Farthing, SK Purpose: The purpose was to apply cross-education (Contralateral Arm Strength Training CAST) during recovery from unilateral distal radial fractures in women in middle and older adulthood and to evaluate its effects on muscle strength, range of motion and patients' selfreported wrist evaluations. Method: Eighteen women were randomised to either a normal rehabilitation group (NORM), or a normal rehabilitation plus strength training group (NORM+TRAIN). Normal rehabilitation consisted of forearm casting for 40.8(SD6.2) days, and arm and finger exercises for the injured extremity as prescribed by the orthopedic surgeon. The normal rehabilitation plus strength training group did not only the same injured limb exercises but also performed hand strength training on the uninjured side, completed at home three times/week with five sets of eight repetitions using a handgrip trainer. Strength training of the uninjured hand began immediately after the first visit to the orthopedic surgeon (week one). Peak force via a handgrip dynamometer and range of motion (flexion/extension; supination/pronation) via a goniometer were measured at week one on the uninjured side, and at weeks nine and 12 post-fracture on both the fractured and non-fractured sides. Patients completed the Patient Rated Wrist Evaluation (PRWE) at weeks nine and 12 post-fracture. Results: The mean age of the women recruited was 63.2 years (SD:10.3). The uninjured hand in the NORM+TRAIN group increased strength from week one [25.5(SD6.8)] to week nine [27.7(SD7.8)], and week one to week 12 [28.3(SD8.0)] - p<0.05. No significant differences were found in the uninjured hand of the NORM group. For the hand on the side of the fracture, percent change at weeks nine and 12 was used to normalize strength to the uninjured hand at week one. Results showed NORM+TRAIN had less of a deficit in strength [-40.8%(SD21.4)] at 12-weeks post fracture compared to NORM [-65.1%(SD21.7)] - p<0.05. There were no significant differences in strength at week nine between groups, although there was less of a deficit for NORM+TRAIN [-59.7%(SD23.7)] compared to NORM [-72.2%(SD20.5)]. For range of motion at 12-weeks post fracture NORM+TRAIN had significantly improved wrist flexion [45°(SD9.8)], and extension [52°(SD12.3)] compared to NORM [33.5°(SD11.5)] [34°(SD19.9)], respectively - p<0.05. No other significant differences for range of motion were found. No significant differences were identified in PRWE scores between the two groups at both weeks nine and 12. Conclusion: Strength training of the uninjured limb during the early care of a distal radius fracture improved the strength and range of motion of the fractured limb 12 weeks after the fracture, over that achieved by conventional treatment. These results have important implications for rehabilitation strategies following distal radius fractures. 155: Prognostic Factors for Reoperation Following Plate Fixation of Fractures of the Midshaft Clavicle Emil H Schemitsch, ON; Laura A Schemitsch, ON; Lynn Vicente, ON; Paul Kuzyk, ON; Michael D McKee, ON Purpose: Plate fixation of midshaft fractures of the clavicle has become an accepted treatment technique for completely displaced injuries. However, little information is available regarding reoperation, a frequent concern. We conducted a retrospective review to determine which prognostic factors were associated with reoperation following plate fixation of completely displaced mid-shaft fractures. Method: We identified 235 consecutive patients who underwent plate fixation for a midshaft clavicle fracture at a single university-affiliated Level One trauma center between July 1, 2000 and July 1, 2009. We examined for 21 possible prognostic variables using multivariate logistic regression analysis and documented reoperation rates. Results: Two hundred and thirty five patients were identified. Eighty-two patients had less than two year follow-up and were excluded from the study: none of these patients had had any further surgery at the time of last follow-up. One hundred and fifty three patients were contacted and assessed (65% of the total cohort). Fifty-eight of these patients had had reoperations (38%), with eight of these individuals requiring multiple procedures (5%). The majority of individuals had reoperation for plate removal (50/153, 33%), while the others were for nonunion, hardware failure, refracture, or infection (8/153, 5%). Plate removal was associated with the use of straight, non-contoured plates, and height <175 centimeters (p<0.01). Risk factors for multiple reoperations (i.e. for infection, nonunion, fixation failure etc), included substance abuse (illicit drugs or alcohol), diabetes, and age >55 years (p<0.01). This information can be used prognostically: for example, use of a contoured plate in a person >175 cm tall results in a plate removal rate of only 9%. Conversely, substance abuse increases the risk of requiring multiple reoperations from 3% to 25%. Conclusion: We have presented the largest series to date that defines the rate of, and risk factors associated with, reoperation following plate fixation of displaced midshaft fractures of the clavicle. Our assessment of 153 patients provides some useful clinical information for treatment and prognosis. Plate fixation of the clavicle is a safe, reliable operation with a low major complication rate (5%). The rate of plate removal is significant (33%), and associated with the use of straight plates: precontoured plates decrease this rate. Shorter (smaller) patients had an increased rate of plate removal and can be counseled accordingly. Patients with substance abuse issues, diabetes, or age >55 years had a significantly higher need for multiple reoperations due to serious complications such as fixation failure or infection. Given the relatively narrow risk-benefit profile of clavicle fracture fixation, extreme caution should be used in recommending primary operative repair in these individuals. 156: The Impact of Region Wide Interventions Aimed at Improving the Timing of Hip Fracture Surgery on Wait for Surgery, In-Hospital Mortality and Length of Stay Eric R Bohm, MB; Lynda Loucks, MB; Ili Slobodian, MB; Luis Oppenheimer, MB Purpose: The timing of hip fracture repair has been shown in retrospective analysis to have an impact on mortality, with delays longer than 24-48 hours resulting in increased risk of death. However, these findings need to be confirmed in an adequately powered prospective study. In 2005, Canada’s health ministers agreed to prioritize efforts aimed at completing hip fracture surgery within 48 hours of admission. The CIHI Health Indicators report found that our region had one of the longest waits for hip fracture surgery in Canada in 2005. This prompted coordinated efforts to improve the timeliness of surgery at the five hospital sites in our region. The purpose of this study was to prospectively evaluate the effectiveness of these efforts on time to surgery, in-hospital mortality, and length of stay. Method: The region-wide interventions to reduce delays to hip fracture surgery included; implementation of standardized tracking procedures, identification of common reasons for inappropriate delay, provision of educational sessions, modification of emergency OR booking rules, and direct written communication with sites, surgeons and anesthetists. Data on time to surgery and length of stay was collected using the Discharge Abstracting Database (DAD) and the National Rehabilitation System (NRS), while mortality data was collected from both the DAD and the provincial health database. Data consisted of 5213 admissions for hip fracture in patients 50 years or older, grouped into three time periods: Before Intervention (1 Jan 2004 to 31 Dec 2007), During Intervention (1 Jan 2008 to 31 Dec 2008) and After Intervention (1 Jan 2009 to 30 June 2011). Results: The mean patient age was 81.4 years, with 72.1% of patients being female; there were no statistical differences in patient demographics by study period. The mean time to surgery decreased from 3.4 days Before intervention, to 2.6 days During the intervention period, to 1.8 days After the intervention period (p<0.0001). Length of stay decreased from 30.0 days Before to 23.9 days After the intervention period (p<0.0001). The overall in-hospital mortality appeared to remain consistent at 6.4% Before, and 6.0% After the intervention period, a difference of 0.4% (95%CI -1.7 to +1.0, p=0.53). Conclusion: It appears that coordinated, region-wide interventions aimed at reducing time to hip fracture repair can result in significant improvements in wait time to surgery and length of stay. However we could not detect any impact on overall in-hospital mortality. Further analysis is required to determine if there are differences in mortality risk by age group, or with longer follow-up. 157: Surgical Fixation of Vancouver Type B1 Periprosthetic Femur Fractures - A Systematic Review Niloofar Dehghan, ON; Bill Ristevs.ki, ON; Michael D McKee, ON; Emil H Schemitsch, ON Purpose: Periprosthetic fractures are a devastating complication of total hip arthroplasty. Type B1 periprosthetic fractures occur at the tip of a stable implant, and may be treated with open reduction and internal fixation (ORIF). However many different fixation techniques have been described with no consensus on the best technique. Current treatment strategies include use of cortical strut allografts alone, cable-plates or compression plates with/without cortical strut allografts, and locking plates. This systematic review of literature investigates the outcomes of these different treatment strategies. Method: A literature review was conducted focusing on surgical fixation of type B1 periprosthetic fractures. Two independent reviewers reviewed the potential studies, and 19 studies were included for final analysis. These were all retrospective case series, with no randomized control studies or prospective cohort trials. Studies were analyzed and categorized depending on the method of fixation: 1) ORIF with strut allografts alone, 2) ORIF with cableplate/compression plates, 3) ORIF with cable-plate/compression plate and cortical strut allograft, 4) ORIF with locking plates. Data analysis was performed comparing rates of union, non-union, malunion, hardware failure, infection, re-operation, and total complications. Results: Nineteen studies were identified with a total of 280 patients at final analysis. The rate of total complications for all patients (N=280) was 34%: with 5% non-union, 6% malunion >5°, 5% hardware failure, 5% infection, and 12% re-operation. These varied between the four different treatment groups. Cortical struts allografts alone were used in 26 patients, cableplate/compression plates were used in 149 cases, cable-plate/compression plates with cortical strut allografts were used in 42 cases, and locking plates were used in 63 cases. Cortical strut allografts alone vs. locking plates had significantly lower rates of total complications (19% vs 48%, P=0.02), but trended towards higher rate of malunion (12% vs 2%, P=0.08). Cableplate/compression plates vs. locking plates had significantly lower rate of hardware failure (3% vs 14%, P=0.007), and total complications (32% vs 48%, P=0.02), with a trend towards lower rate of non-union (4% vs 11%, P=0.06). Cable-plate/compression plates with cortical strut allografts vs. locking plates had significantly lower rate of total complications (29% vs 48%, P=0.04), and trended towards lower rates of hardware failure (2% vs 14%, P=0.07). Conclusion: This systematic review suggests that with regards to fixation of type B1 periprosthetic femur fractures, locking plates have significantly higher rates of total complications compared to the other three fixation options, and significantly higher rate of hardware failure compared to cable-plate/compression plates. There are limitations to this study, and further investigation with high quality randomized control trials is needed to further assess these outcomes. 158: Systematic Follow-up of Osteoporotic Fracture: Preliminary Results of a Multidisciplinary Approach Josee Delisle, QC; Julio Fernandes, QC; Yves Troyanov, QC; Pierre Beaumont, QC; Benoit Benoit, QC; Sylvain Gagnon, QC; Alain Jodoin, QC; G Yves Laflamme, QC; Stephane Leduc, QC; Jean-Marc Mac-thiong, QC; Michel Malo, QC; Gilles Maurais, QC; Stefan Parent, QC; Pierre Ranger, QC; Sylvie Perreault, QC Purpose: Only 12% of the fractures that we treat each year receive a treatment for osteoporosis in our orthopaedic surgery department. The 2010 clinical guidelines of Osteoporosis Canada for the diagnosis of osteoporosis, indicates that patients that have sustained a fragility fracture have a higher risk of sustaining a subsequent fracture. We are validating a multidisciplinary systematic follow-up approach for osteoporosis and patients are managed by a clinical nurse specialist. We aim to evaluate the impact of a multidisciplinary approach on the incidence of a subsequent fragility fracture, on initiation of a treatment (evaluation of compliance and adherence to treatment) and treatment efficacy (bone markers). We will also evaluate the functional outcome and quality of life post-fracture. Method: We are recruiting 543 patients (men and women) over 40 years of age who were treated for a fragility fracture at the orthopaedic clinic of Hôpital du Sacré-Cœur de Montréal. After starting a treatment protocol for osteoporosis, we evaluate the compliance and adherence to treatment, bone markers (CTX-1 and Osteocalcin) and the subjects fill up functional outcome questionnaires at different time intervals over a 24 months period. Results: Two hundred thirty-five patients (28 men and 207 women) were enrolled with a mean age of 62.0 y.o (+ 12.9) and a mean FU of 4.5 months (+ 3.5). Fifteen patients (6.4%) dropped out after six months. One of them died. Three patients were excluded (1.3%). Mean patient’s age was 64.4 y.o (+ 12.9) with a mean FU of 4.6 months (+ 3.9). Fifty-five patients (23.4%) were already on bisphosphonates and 92 pts (39.1 %) had already sustained a fragility fracture. All patients were prescribed risedronate except eight that were prescribed zoledronic acid for intolerance or contraindication to oral bisphosphonates. Ten patients qualified for teriparatide and two patients accepted to start the treatment. SF-12 was statistically higher (p< 0.000) at last follow up than baseline (PCS: 42.5 vs 37.7 and MCS: 49.3 vs 47.4; respectively). Up to now, we obtained 91.9% persistence. After validation, 15% of the patients needed to be referred to a rheumatologist and 85% of the patients were managed by the clinical nurse specialist. Conclusion: In our orthopaedic surgery department, the osteoporosis treatment rate went from 12 to 64.8 % after implementation of our multidisciplinary systematic follow up of fragility fractures. The 91.9% persistence rate in the first year compares favorably with the 50-75% rate cited in the literature. Management of the underlying osteoporosis that leads to fragility fractures could be done by Clinical Nurse Specialists. We believe this program is a plus value to orthopedic surgery because it provides a fracture registry as well as a functional outcome database for all fracture patients. 159: Systematic Review of the Treatment of Periprosthetic Distal Femur Fractures Bill Ristevski, ON; Aaron Nauth, ON; Dale Williams, ON; Jeremy Hall, ON; Daniel Whelan, ON; Mohit Bhandari, ON; Emil H Schemitsch, ON Purpose: To systematically review and compare non-operative and operative treatments for the management of periprosthetic distal femur fractures adjacent to total knee arthroplasties. Specific operative interventions compared included locked plating, retrograde intramedullary nailing (RIMN), and conventional (non-locked) fixation. Method: A comprehensive database search (via Pubmed, Medline, Cochrane Database, OTA and AAOS Databases) was completed, yielding 44 eligible studies with a total of 719 fractures for analysis. Pertinent outcomes including nonunion, malunion and the need for secondary surgical procedures were compared statistically. Results: Both locked plating and RIMN showed significant advantages over non-operative treatment. Locked plating also had a significantly lower malunion rate when compared with RIMN and conventional fixation. A subset analysis comparing surgical treatments is shown in the table below. Nonunion...............Malunion................SSP........... Conventional vs Locked Plating.......9.2% vs 8.8%........19.2% vs 7.6%......16.7% vs 13.3% OR (95% CI)..........1.05 (0.55-2.02)......2.87 (1.53-5.38).....1.30 (0.78-2.18) p value..................0.87......................0.001*...................0.32 Conventional vs RIMN....................9.2% vs 3.6%........19.2% vs 16.4%....16.7% vs 9.1% OR (95% CI)..........2.68 (0.87-8.25).....1.21 (0.64-2.29)......2.00 (0.93-4.29) p value..................0.08......................0.55......................0.07 RIMN vs Locked Plating......3.6% vs 8.7%........16.4% vs 7.6%.......9.1% vs 13.3% OR (95% CI).........0.39 (0.13-1.15)......2.37 (1.17-4.81)......0.65 (0.31-1.35) p value.................0.09.......................0.02*.....................0.25 Conventional = Non-locked fixation; RIMN = Retrograde intramedullary nailing; OR = Odds Ratio; CI = Confidence Interval; SSP = Secondary surgical procedure; * denotes significant p value Conclusion: Locked plating and RIMN offer significant advantages over non-operative treatment and conventional (non-locked) fixation techniques in the management of periprosthetic femur fractures above total knee arthroplasties. When locked plating was compared to RIMN, there were no statistically significant differences in the rates of nonunion and revision surgery. However, this review demonstrated that the rate of malunion was significantly higher with RIMN compared to locked plating (OR=2.37,95% CI=1.17-4.81, p=0.02). These results suggest that locked plating may offer superior outcomes in the management of periprosthetic fractures of the femur following total knee arthroplasty. 160: The Temporal Pattern of Radiographic Loss of Reduction in Closed Management of Distal Radial Fractures in 221 Women 50 years and Older Presenter: Geoffrey Johnston Purpose: To document the temporal pattern of change of three radiographic parameters during non-operative treatment of distal radial fractures in women 50 years and older Method: The radiographic parameters of radial inclination (RI), ulnar variance (UV) and tilt were measured after closed reduction of a fracture of the distal radius in a population of women 50 years and older, and who were treated non-operatively. The same parameters were measured at weeks one, two, three, six, nine and twelve in these women. The women were assigned to two groups, those in whom the dominant arm was involved, the other, those in whom the non-dominant arm was fractured. Results: Two hundred and twenty-one women 50 years and older who were treated by closed reduction and non-operative management of a displaced distal radial fracture were evaluated. One hundred and one (101) were of the dominant extremity, and 120 were of the nondominant extremity. Not all women had x-rays at each of the time periods. The averages for each time period were calculated. The mean post-reduction values in the dominant and nondominant injured arms for radial inclination were 20 degrees and 22 degrees, and at week one, 19 degrees and 20 degrees, and 18 degrees and 19 degrees at two, three, six, nine and twelve weeks, respectively. The mean post-reduction values in the dominant and nondominant injured arms for ulnar variance were 1.4 mm and 1.3 mm, and at week one, 2.0 mm in both, at week two 2.1 in both, at week three 2.5 mm and 2.8 mm, at week six 3.6 mm and 3.3 mm, at week nine 3.3 and 3.1 mm, and at twelve weeks 3.4 and 3.1 mm, respectively. The mean post-reduction values in the dominant and non-dominant injured arms for tilt were -4 degrees and -5 degrees (a minus value denotes volar tilt, a positive value dorsal tilt), and at week one -1 degrees and -2 degrees, at week two 0 degrees and -1 degrees, at week three 3 degrees and 1 degrees, at week six 5 degrees and 2 degrees, at week nine 2 degrees and 1 degrees, and at twelve weeks 4 degrees and 2 degrees, respectively. Conclusion: In general, radial sided fracture settling, reflected by diminishing radial inclination appears to stabilize by week two post fracture. In contrast, axial radial shortening and dorsal fracture collapse, reflected by increasing ulnar variance and dorsal tilt, respectively, appear to stabilize later, between three and six weeks post-fracture. 161: Adamantinoma of Bone Courtney Erin Sherman, US; Eduardo N Novais, US; Doris Wenger, US; Peter Rose, US; Franklin Sim, US Purpose: The purpose of this study is to investigate the clinical presentation and oncological outcomes of patients with adamantinoma treated surgically in a single institution. Method: Forty patients with a histologic confirmed classic adamantinoma were treated in our institution between 1939 and 1999. The medical clinical records, radiographs, advanced imaging, histologic and operative reports of these patients were retrospectively reviewed. Institutional Review Board approval was obtained. Demographic data, presenting symptoms and clinical findings on physical examination were recorded. Data about the treatment modality were obtained. Histologic analysis confirmed the diagnosis in all cases according to previously established criteria. Follow-up data included clinical and radiographic information focusing on complications, local recurrence, metastasis and overall survival after treatment and its management. All patients were followed for at least two years and the mean duration of followup was 12.8 years (range, 12-469 months). Results: We reviewed 40 cases of adamantinoma of long bones. Twenty-eight occurred in the tibia, six in the tibia and fibula, one in the femur, two in the ulna, one in the fibula, one in the humerus, and one in the radius. Most patients presented with pain and swelling. The mean age was 13 years (seven-79 years). Thirty four patients were treated initially with a limb sparing surgery and eight with an amputation. The survival rate of the entire series was 78.6% with a mean follow-up of 13 years. Eight (20%) patients had recurrent local disease, nine (22.5%) developed lung and/or lymph node metastasis. Nine patients died of their disease at mean follow up of 10 years (nine months to 21 years) and most of them were initially treated with an amputation (p=0.04). No statistical differences were observed in others risk factors for recurrent or metastatic disease. Conclusion: Our results indicate that amputation doesn’t improve the survival rate of this group of patients, wide en bloc resection is the treatment of choice. All patients require longterm follow-up for evidence of local recurrence or metastasis. 162: Bone Metastases from Renal Cell Carcinoma – En-bloc or Intralesional Resection? Benjamin Deheshi, ON; Antonella Racano, ON; Osama Al-Shaya, ON; Emad Al-Absi, ON; Michelle Ghert, ON Purpose: Bone metastases from renal cell carcinoma (RCC) are highly resistant to radiation and chemotherapy and must often be treated surgically to avert pathological fracture. However, surgical management remains controversial and must be tailored to an individual’s prognosis and functional status. The objective of this study was to determine the oncologic outcome of en-bloc resection vs. intralesional curettage vs. intramedullary nailing (IMN) of bone metastases from RCC. Method: A prospectively collected database of 50 bone metastases from RCC (involving the pelvis and the extremities) in 41 patients treated at the Juravinski Cancer Center in Hamilton, Ontario, Canada, between 1996 and 2010, was reviewed. Patients with a minimum follow-up of 12 months, or less than 12 months survival were included. Available data included: demographics, site, type of surgery, pattern and timing of metastasis, local recurrence or progression, and survival time. Results: A total of 31 patients with 43 lesions were included in the review. Fourteen patients (42%) had visceral metastases at presentation, while 17 patients (58%) presented with bone metastases only. The initial procedure was en-bloc resection in 13 patients (42%), intralesional curettage in nine patients (29%), and IMN in nine patients (29%). Two lesions (13%) treated by en-bloc resection recurred locally, while four lesions (14%) in the curettage/IMN groups progressed locally; one case of local progression from each treatment group required further surgery. The average survival was 30.5 months following en-bloc resection and 17 months following curettage/IMN. Conclusion: The results reaffirm that patients with RCC metastases to bone can have prolonged survival. Interestingly, there was no significant difference in local tumor recurrence or progression between en-bloc and intralesional groups. Overall survival time appears to be better following en-bloc resection in patients with isolated bone metastases; however this may be due to a selection bias. Patients who presented with visceral metastases, show no marked differences in survival times between en-bloc and intralesional groups. Future studies would include the impact of primary tumor biology, sensitivity to adjuvant treatment, and surgical approach on functional outcome and survival in a prospective multi-center trial. 163: Effect of Chemotherapy and Cement Fixation on Tumour Endoprosthesis Survival Bas A Masri, BC; Luke Pugh, BC; Paul W Clarkson, BC Purpose: To determine the effects of chemotherapy and cemented or uncemented fixation techniques on tumor endoprosthesis survival at our center. Method: We performed a retrospective cohort analysis of 54 consecutive patients who underwent lower limb salvage surgery incorporating tumor endoprostheses (Stryker GMRS system or DePuy Orthogenesis LPS system) at Vancouver General Hospital between 1990 and 2008. We compared the rates of radiographic loosening and revision among patients who received perioperative chemotherapy and those who did not, then further analysed the effect of cement fixation on these parameters. Inclusion criteria were: primary bone malignancy in the lower limb and ≥2 years from index operation. Statistical analysis was performed using Fisher’s exact test and Kaplan-Meier survivorship curves. Results: Forty-three percent (23/54) of patients received perioperative chemotherapy and 57% (31/54) did not. Eighty-one percent (44/54) of patients had cement fixation and 19% (10/54) did not. Post-operative radiographs were not available for 4 patients. Radiographic evidence of prosthesis loosening was present in 6/50 (12%). Revision surgery was required in 12/54 (22%) patients, due to periprosthetic or prosthetic fracture (5/12), loosening (3/12), local recurrence (2/12), recurrent joint instability (1/12), and infection (1/12). Using Fisher’s exact test, perioperative chemotherapy did not affect the rate of radiographic loosening or revision for loosening. It did, however, increase the total revision rate (p=0.02). Cement fixation resulted in significantly less radiographic loosening (p=0.01) and trended towards reduced revisions for loosening (p=0.08). It did not alter the total revision rate. Using Kaplan-Meier curves chemotherapy was again shown to increase the total revision rate (p=0.03) but not revision rate for loosening or radiographic loosening. Similarly, based on the curves, cement fixation affected radiographic loosening (p <0.0001) and revisions for loosening (p=0.01) but not total revision rate. When stratifying chemotherapy and non-chemotherapy groups by cement fixation, use of cement was found to significantly reduce radiographic loosening (p=0.001) and revision for loosening (p=0.016) in both. Use of cement did not however reduce the total revision rate in either the chemotherapy or non-chemotherapy groups. Conclusion: Use of chemotherapy increases the total revision rate of tumour endoprostheses but not aseptic loosening. Cement fixation has lower rates of radiographic loosening and revision for loosening in tumour endoprostheses regardless of whether chemotherapy is given concurrently. We recommend the use of cement for prosthetic fixation as it improves construct stability regardless of chemotherapy use. 164: Giant Cell Tumor Arising in the Distal Tibia Saleh A Alsulaimani, QC; Peter Ferguson, ON; Jay S Wunder, ON; Marc Isler, QC; Sophie Mottard, QC; Joel M Werier, ON; Benjamin Deheshi, ON; Norbert Dion, QC; Michelle Ghert, ON; Robert Turcotte, QC Purpose: To assess the management and outcome of distal Tibia GCT Method: Patients with distal Tibia GCT managed in Canadian bone tumor centers. Results: 32 patients were recorded between 1991 and 2010. There were 28 primary tumors and 4 were recurrent lesions. The mean follow up was 5 years (1– 16). The mean age was 34 yrs (15-63). Radiographic grading was 3 grade 1 , 19 grade 2 ,9 in grade 3 and 2 indeterminate. The mean largest diameter was 3.3cm (1-12 cm). 5 presented with minimally displaced fractures (4 extra articular). Mean Initial MSTS score was 27 (23-35) and the mean initial TESS was 77.74 (45-100). All lesions were managed with curettage. High Speed Burring was used for 31 pts. Hydrogen Peroxide was used on 3 pts, phenol in 5 pts and liquid nitrogen in one. Pulsated lavage was recorded in 11 pts. The cavity was filled with cement only in 5, cement and allograft in 3, 15 had morselized auto/allograft including 4 with the addition of strut allografts. 14 were supplemented with internal fixation. None received radiotherapy. Postoperative complications included one infection and one non-union. 9 patients developed local recurrence. They were all managed with additional curettage. Cement was used in 8 and morselized allograft in one. None required additional internal fixation and one received postoperative radiotherapy. No complication was recorded in this group. 3 pts went to develop an additional local recurrence. Again all were curetted without internal fixation and cement was used in 2. One also got radiotherapy. No complication occurred. No lung metastases developed. At latest follow up 29 were alive without evidence of disease, 2 were alive with disease and 1 pt died from an unrelated cause. The mean final MSTS score was 32 (25-35) and the mean TESS final score was 88 (35-100). Conclusion: Giant cell tumor involved rarely the distal tibia. Curettage was possible in all but with a high incidence of recurrence. Ultimate function was found very good. 165: Giant Cell Tumour of the Distal Radius: A Review of 75 Cases Krista Goulding, ON; Ajay Puri, IN; Ashish Gulia, IN Purpose: Giant cell tumor (GCT) of the distal radius is a rare, benign disease whose propensity for locally aggressive behavior and recurrence has rendered decisions on treatment modalities challenging. The objective of the study was to evaluate different surgical modalities based on their recurrence rates and functional outcome to ascertain best practices for this disease. Method: Seventy-five consecutive patients (37 females; 38 males) presenting with a GCT of the distal radius between September 2005 and February 2011 were retrospectively analyzed. Thirty-eight patients presented with a primary GCT, while 37 had recurrences initially treated at peripheral hospitals. Grade 3 Campanacci lesions were present in 53 patients. Thirty-five patients had an intralesional excision (curettage with bone grafting (23) or cementing (12)), and 39 patients underwent resection and reconstruction (arthrodesis using iliac crest (2), nonvascularized fibula (6), ulnar translocation (31) and prosthetic replacement (1)). One patient required an amputation. The mean follow-up for all patients was 24 months (range, 1 to 106). Patients were evaluated for recurrence with local and systemic staging, and local function using MSTS scores. Results: Nineteen patients (25.3%) had a local recurrence (LR); 14 cases were multiple. LR rates in the primary GCT group as compared to the recurrence group were 14.7% and 10.7%, respectively (p<0.05). For those patients undergoing wide resection, LR rates were 20.0%, versus 40.0% after intralesional excision (p<0.005). Campanacci Grade 3 lesions recurred in16 of 53 cases, or 30.0%. This was significantly higher than in Grades 1 and 2, which had a LR in 5 of 22 (22.7%) (p<0.05). Four patients required conversion from curettage to wide resection and arthrodesis, and two developed lung metastases, one of which underwent a metastatectomy. The mean MSTS score was 27.4 in the curettage group and 25.9 in the wide resection group (p=0.3). Conclusion: GCT is an aggressive primary bone tumor with high rates of recurrence. Previous intervention, intralesional excision and Grade 3 Campanacci lesions increase the risk of local recurrence. Similar functional results were observed in both intralesional excision and wide resection with arthrodesis. Wide resection is the preferred option for Campanacci Grade 3 lesions, and ulnar translocation provides an acceptable reconstruction method with good functional outcomes. 166: Risk Factors for Local Recurrence Following Resection of Superficial Soft Tissue Sarcomas: A Review of 467 Patients William Eward, ON; Anthony Griffin, ON; Patrick O'Donnell, ON; Peter Chung, ON; Charles Catton, ON; Brian O'Sullivan, ON; Jay S Wunder, ON; Peter Ferguson, ON Purpose: Soft tissue sarcomas are most frequently located deep within fascial compartments of the extremities. Superficial soft tissue sarcomas are relatively less common. They may be managed differently than deep sarcomas because generous margins are often possible without sacrificing critical structures. Radiotherapy may be utilized less often because of these generous margins. However, small superficial soft tissue sarcomas are often not promptly recognized as such and may be frequently treated with inadequate oncologic excision prior to referral to a sarcoma centre. The effect of these factors on local control has not been well documented. Method: We reviewed 467 patients with superficial soft tissue sarcoma from our prospectively maintained database at the University of Toronto/Mount Sinai Hospital between 1989 and 2009. Minimum follow-up was 2 years. Mean follow up was ten years. Patients were assessed for histologic tumour type, size, grade, location, adjuvant treatment, and prior surgery. These factors were correlated with local or systemic recurrence, survival, and complications. Results: The most commonly represented tumours were undifferentiated pleomorphic sarcoma (UPS, 32 percent), leiomyosarcoma (16 percent), and dermatofibrosarcoma protuberans (DFSP, 12 percent). There were 131 (28 percent) grade 1/3 tumours, 133 (28.5 percent) grade 2/3 tumours, and 202 (43 percent) grade 3/3 tumours. 423 tumours (91 percent) were excised with negative margins while 39 (8.4 percent) were excised with microscopically positive margins and three (0.6 percent) were excised with grossly positive margins. There were 31 (6.8 percent) local recurrences. 55 patients (12.1 percent) developed distant metastatic disease following treatment. Having had surgery prior to referral to our center was a risk factor for local recurrence (p=0.03) and this scenario accounted for 17 of the 31 local recurrences (54.8 percent). Relative risk for local recurrence by histopathological diagnosis, grade, surgical margin, adjuvant therapy, and location are also reported. Conclusion: Superficial soft tissue sarcomas are often treated differently from traditional deep sarcomas. Because they are frequently not recognized as sarcomas, they are treated inappropriately prior to referral to a sarcoma centre. Operative treatment prior to referral and definitive diagnosis is a risk factor for local recurrence. 167: The Effect of the Nature of a Positive Margin on Local Recurrence for Extremity Soft Tissue Sarcoma Patrick O'Donnell, ON; Anthony M Griffin, ON; Peter Ferguson, ON; William C Eward, ON; Peter W M Chung, ON; Charles N Catton, ON; Brian O'Sullivan, ON; Jay S Wunder, ON Purpose: To evaluate the risk of local recurrence after extremity soft-tissue sarcoma (STS) resection with positive surgical margins, and the safety of sparing adjacent critical structures in this setting. Method: 257 patients with extremity STS who had a positive resection margin were identified from a prospective database of 1,458 patients. Patients with positive margins were stratified into four groups, each representing a specific clinical scenario and thought to be associated with increasing risk: 1) low-grade liposarcoma; 2) positive margins planned preoperatively to preserve a critical structure (bone or major nerve or blood vessel); 3) positive margins on reexcision following a prior unplanned excision elsewhere; and 4) unplanned positive margins. The rate of 10-year local recurrence-free survival was calculated for all groups. Results: 10-year local recurrence-free survival decreased incrementally from group 1 to group 4 (92.7% to 64.9%; p < 0.01). The rate of local recurrence-free survival following planned positive margins to preserve critical structures (79.8%; group 2) was significantly higher than after positive margins following prior incomplete excision (69.3%; group3) or unplanned positive margins (64.9%; group 4). In comparison, the 10-year local recurrence-free survival after sarcoma excision with negative margins was 90.4%. Conclusion: These results show that the risk of local recurrence after resection of a STS with positive margins can be predicted based on the clinical context and supports this type of classification. In addition salvage of critical structures including bone and major nerves and vessels directly adjacent to STS is relatively safe when planned ahead as part of multidisciplinary management.. This information carries important decision-making implications for management of patients at risk of positive margin resection of a STS. 168: Ths Susceptibility of Human Bone and Soft Tissue Sarcoma to Vaccinia and Maraba Oncolytic Virus Joel M Werier, ON; Hesham Abdelbary, ON; Jovian Tsang, ON; Derek Butterwick, ON; Jay S Wunder, ON; Jean-Simon Diallo, ON; John Bell, ON Purpose: Oncolytic viruses (OV) in cancer therapeutics has provided a novel approach to the treatment of malignancies. These viruses preferentially infect, replicate and kill malignant cells, while sparing healthy tissue. Oncolytic viruses have demonstrated a good safety record and have a lesser adverse side affect profile compared to cytotoxic chemotherapy regimens. To date, the majority of OV research has been directed towards various carcinoma models. The susceptibility of sarcoma to oncolytic virus infection has not been fully characterized. The purpose of this study is to characterize the infective potential of Vaccinia and Maraba virus and in a heterogenic sarcoma panel. Method: Fresh untreated sarcoma samples were collected from both open biopsies and tumour resections. All samples were confirmed to be viable using the Alamar Blue viability assay. Each sample was pre-treated with Suberoylanilide Hydroxamic acid (SAHA) or Trichostatin A(TSA), pro-drugs (histone de-acetylase inhibitors) which may potentiate viral infection. Samples were then infected ex-vivo with a commercially available Vaccinia virus, and Maraba virus. After an incubation period, samples were collected for viral tittering and examined for Green Fluorescence Protein, confirming the presence of infection. Unaffected muscle biopsies were collected as controls. Thirty-six sarcoma samples were infected with Vaccinia and 31 sarcoma samples were infected with Maraba. A viable infection was defined by a 10-fold increase of viral production after incubation. Results: Seventy nine percent of Maraba samples demonstrated viable infection compared to 27% of Vaccinia samples. Maraba infected samples demonstrated fold increases in vital titers compared to Vaccinia infected samples. There was meaningful infection in a wide range of sarcoma subtypes including high grade undifferentiated pleomorphic sarcoma, rhabdomyosarcoma, osteosarcoma, and synovial sarcoma. Healthy muscle tissue collected from the same patient did not show infection. The addition of a pro drug did not enhance infection. Conclusion: Vaccinia and Maraba demonstrated strong infectivity in selected sarcomas samples. Maraba infected a higher percentage of sarcoma subtypes and produced higher vital titers. Further investigation of Vaccinia and Maraba virus as potential therapeutic agent for sarcoma therapy is warranted 169: Early Outcomes with Reverse Total Shoulder Arthroplasty in Patients with Rheumatoid Arthritis Danny P Goel, BC; Robert B Butler, US; Anup A Shah, US; Rachel Fowler, US; Jon JP Warner, US; Laurence D Higgins, US Purpose: The purpose of this study was to evaluate the indications for and report the subjective and objective outcomes following reverse total shoulder in the rheumatoid population. Method: A retrospective chart review identified 19 rheumatoid patients which had undergone a reverse total shoulder arthroplasty. Sixteen patients were available for prospective evaluation. Eight patients were indicated for cuff tear arthropathy, 2 for fracture and 6 as revision surgery for failed arthroplasty. All patients had routine follow up. Demographic information as well as objective and subjective measures were recorded. Imaging studies were evaluated for the presence of notching and loosening of the implants. Results: Sixteen patients were included in the final analysis. There were 2 males and 14 females with an average age and follow up of 65.4 years (56-77) and 21.1 months (average 658 months), respectively. Range of motion improved in forward elevation from 42 to 94 degrees (p = 0.002), external rotation 17 to 29 (p = 0.1306) and internal rotation from side to buttock (p = 0.0950). Visual analog scale and subjective shoulder value improved from 8.8 to 1.5 (p = 0.0001) and from 22.5 to 66.3 (p = 0.0014), respectively. Overall the majority of patients were satisfied with their outcomes however 100% of primary inverse patients would undergo surgery again whereas 86% or revision inverse patients would undergo surgery again. Patients with revision procedures and those with complications had lower subjective and objective outcomes compared to those with primary reverse arthroplasties. Notching was noted in 56% of all patients (average notching Nerot stage 2). There was a 37% overall complication rate where 5 out of 6 patients undergoing revision inverses had a complication (two patients with dislocations, 1 patient with a post-operative periprosthetic fracture, 1 patients with base plate loosening, 1 patient with radial nerve palsy). Conclusion: Overall rheumatoid patients note objective and subjective improvements in pain and function following reverse arthroplasty. The stratified outcomes remain highly dependent on the indications for surgery. Although this low demand population generally does well, a high complication rate is associated with revision of a previously failed implant. 170: Fractures of the Greater Tuberosity of the Humerus: A Study of Impact of Rotator Cuff and Biceps Pathology on Function Jennifer Mutch, QC; Luo Jun Wang, QC; Dominique M Rouleau, QC; G Yves Laflamme, QC; Nicola Hagemeister, QC Purpose: Dominique M Rouleau, MD, Msc., FRCSC: HSCM, Université de Montréal Outcome after proximal humerus fracture is known to be variable. Fractures of the greater tuberosity represent a particular challenge as the fragment serves as the insertion site for muscles of the rotator cuff tendons and is the lateral floor of bicipital grove. Tendinomuscular injuries occurring with fractures of the proximal humerus are of interest. MRIs performed after proximal humerus fractures in general have shown an incidence of 40% full thickness rotator cuff tears. Bhatia also reported 10% severe biceps tendinosis after greater tuberosity fixation. In addition, fatty muscle atrophy has been shown to correlate with functional outcome in rotator cuff tears and shoulder arthroplasty but no such study has been done following isolated greater tuberosity fracture. The objective of this study is to evaluate the incidence of full thickness rotator cuff tear and bicipital pathologies in patients with previous greater tuberosity fracture. Method: A retrospective review of all cases of isolated greater tuberosity fractures seen from 2006 until December 2010 was performed. Patients with adequate initial and follow-up radiographs of an isolated greater tuberosity fracture were invited to return for an ultrasound of their affected shoulder. All of the ultrasounds were performed by the same experienced musculoskeletal radiologist and the contralateral shoulder was used for comparison. Tendinosis, tears, and position of the biceps tendon was noted and any partial or complete rotator cuff tears were identified and measured. Quick DASH, SF12, WORC and pain score were used to assess clinical outcome. Neer classification was used to classified fracture in displaced or not displaced fracture. Results: The 50 recruited patients had an average age of 58 (SD: 15, range 32-92) and 45% were male. Sixty-six percent of the ultrasounds demonstrated at least one partial tear, including 58% of patients under the age of 50. Six patients showed full thickness tear, all of them were male. Biceps evaluation showed 11 subluxations and 28 tendinitis. Patients with full thickness tear were having worst upper limb function as showed by the Q-DASH. (35 vs 16, p=0.05) Also they were reporting more pain. (3.5/10 vs 1.7/10, p=0.05) The biceps subluxation was associated with higher WORC score. (89 vs 73, p=0.05) Conclusion: This study describes the tendinous pathology associated with isolated greater tuberosity fractures of the proximal humerus. Following these fractures, a significant portion of patients was shown to have rotator cuff pathology regardless of age. We don’t know if they are secondary to the fracture or pre-existing pathologies, but they are related to worst outcome. Patients with greater tuberosity fractures may benefit from additional imaging to evaluate their rotator-cuff and biceps when expressing less favorable outcome. However, larger clinical studies are needed to evaluate the functional impact of the associated rotator-cuff and biceps injury. 171: Navigation Of Guidewire Placement Using Volume Slicing Of 3D Cone-Beam Computed Tomography (CBCT) Images For Percutaneous Scaphoid Fixation David Pichora, ON; Erin Smith, ON; Hisham A Al-Sanawi, ON; Braden Gammon, ON; Randy E Ellis, ON Purpose: Percutaneous scaphoid fixation (PSF) classically involves drilling a guidewire along the scaphoid over which a cannulated screw is placed to stabilize the fracture. Stability is linked to maximizing the length and central placement of the screw, yet is challenging due to the small size and complex geometry of the bone; this typically results in liberal use of conventional 2D fluoroscopic C-arm images for guidance. This study aimed to evaluate if image-guidance technology can improve placement and reduce x-ray exposure in this procedure. Method: An in-vitro study was conducted to compare volume-sliced (VS) navigation to conventional C-arm guidance (n=24). A model wrist featuring a replaceable scaphoid was constructed to permit direct comparison between the two trial groups. Each trial involved inserting a guidewire using a volar approach with the goal to maximize both central placement and length of its position. Subsequently, the drilled scaphoids were CT-imaged to measure length and depth of the guidewire path. A computer-algorithm was used to determine the paths maximizing depth and length of the model scaphoid to compute an optimal target zone. Length and depth of guidewire placement, drilling attempts and x-ray exposure were used as comparative measures. In the VS technique a 3D digital angiographic C-arm was rotated 180 degrees to take an intraoperative 3D cone-beam x-ray (CBCT) image of the wrist. Using computer algorithms, the 3D image was volume-rendered and sliced along the anatomical planes to produce a 2D image series similar to CT slices; however unlike CT slices, the viewing orientation, slice thickness and spacing could be varied. The surgeon used these images to create a target plan by positioning a virtual screw on the 3D image. The image slices were reconfigured in the plane of the target path for navigation. A drill guide equipped with infrared markers allowed the orientation of the guidewire to be tracked by a camera during drilling. A novel preoperative calibration step was used to show the real-time position of the tracked drill relative to the VS images, avoiding patient-based registration characteristic of most image-guided orthopaedic interventions. Results: The VS group had a higher mean depth (i.e., central placement; p<0.05), but no significant difference in length. There were 83.3% of navigated trials and 75.0% of the conventional trials within the optimal zone. VS navigation demonstrated increased precision of guidewire placement (p<0.05). Each VS trial required only one drilling attempt (p=0.00) and resulted in less radiation exposure than conventional C-arm (p<0.01). Conclusion: This study represented a preliminary evaluation of VS navigation using intraoperative 3D CBCT for the purposes of scaphoid fracture repair. Initial results indicate improved guidewire placement, with fewer drilling attempts and less radiation exposure than the conventional technique. We are currently conducting ex-vivo trials and early clinical application. 172: Prevalence of Symptoms of Depression, Panic Disorder and PTSD in an Injured Worker Upper Extremity Clinic Ryan M Degen, ON; Joy MacDermid, ON; James Roth, ON; Darren Drosdowech, ON; Ruby Grewal, ON; Ken Faber, ON; George S Athwal, ON Purpose: Depressive symptoms, anxiety and post-traumatic stress disorder have been associated with musculoskeletal disorders and may act as barriers to recovery in injured workers. Their frequency in this population is not known. The purpose of this study was to identify the prevalence of depression, panic disorder (PD) and post-traumatic stress disorder (PTSD) using the Patient Health Questionnaire (PHQ), a mental health screening tool, in a cohort of patients presenting to an upper extremity injured-worker specialty clinic. A secondary purpose was to investigate the relationship between PD, PTSD, depression and patient reported outcomes. Method: All patients completed the PHQ in conjunction with their initial evaluation by an upper extremity orthopedic surgeon (n=418). Questionnaires completed during 2010 were reviewed. Patients with a positive PHQ, containing domains assessing for depression, PD and PTSD, were reviewed for demographics, diagnosis, self-efficacy scores, DASH and SF-36 scores. The prevalence of each of these disorders, and their relationship with presenting complaints and outcomes, were calculated. Results: 130 patients (31.0%) scored positively on the PHQ; 87 patients (20.8%) for depression, 57 (13.6%) for PD and 65 (15.5%) for PTSD. Patients presenting with neck pain had a significantly higher prevalence of depression (p=0.012) and PD (p<0.001). Patients diagnosed with chronic pain syndrome were found to have a significantly higher prevalence of depression (p=0.014). Patients scoring positive for depression had lower SF-36 mental component scores (p<0.001), and poorer QuickDASH (p=0.003) and DASH (p=0.007) work scores compared to patients who scored positively on other domains of the PHQ, but negatively for depression. Conclusion: A third of patients presenting to the injured worker clinic screened positively for at least one condition on the PHQ. Screening was effective at identifying patients with potential blocks to recovery. Further studies are required to determine whether identification of these mental health disorders can help direct appropriate referral and management and to assess the effect on patient reported outcomes. 173: Fractures of the Greater Tuberosity of the Humerus: Validation of a New Morphologic Classification Jennifer Mutch, QC; Luo Jun Wang, QC; Dominique M Rouleau, QC; G Yves Laflamme, QC; Nicola Hagemeister, QC Purpose: Intro: Isolated fractures of the greater tuberosity are particular in that the fragment serves as the insertion site for muscles of the rotator cuff. While previous studies have demonstrated that as little as 2mm of superior displacement of the greater tuberosity may have a significant negative impact on the function of the affected shoulder, little research has been undertaken to determine whether the type, or morphology of the greater tuberosity fracture affects outcome. Multiple classification systems based on fragment displacement have been previously developed to describe greater tuberosity fractures. The most popular, by Neer, categorizes fractures simply as displaced by more or less than 5mm. A third category, that of a displaced greater tuberosity fracture associated with a glenohumeral dislocation, was later added by the AO. Bahrs et al., however, recently proposed 3 mechanisms for greater tuberosity fracture: avulsion, acromial impaction, and impaction on the glenoid. Using this and our experience with greater tuberosity fractures and their radiographs, we proposed the following new morphologic classification: 1) An avulsion involves small fragments of bone and the fracture line is horizontal. 2) A depression fracture involves a fragment that is displaced inferiorly. 3) A split fracture involves a large fragment with a vertical fracture line that extends to or past the level of the surgical humeral neck. Method: A retrospective review of all cases of isolated greater tuberosity fractures seen at our Institution from 2006 until December 2010 was performed. One hundred thirty-nine cases with adequate standard radiographs of the shoulder were identified. Three observers (an orthopedic surgeon(YL), an orthopedic fellow(AC) and an orthopedic resident(JM)) independently categorized the 139 cases according to the Neer, the AO and the new Morphologic classifications. This was done on two separate occasions with a minimum interval of three weeks. The inter- and intra-observer reliability was then calculated using Randolph’s free-marginal kappa (2005). Results: The relative frequency of the avulsion, split, and depression fracture types was 0.45, 0.36 and 0.17 respectively. The average age of the patients at the time of injury was 58 (standard deviation (SD):15, range: 23-96) and this did not differ significantly among fracture types. Sixty percent of the cases were female patients and this did not differ significantly among fracture types. The incidence of dislocations, however, varied with fracture type and was 21%, 26% and 57% for avulsion, split, and depression fracture types, respectively (p<0.01). The inter-observer kappa was 0.31-0.35 for the Neer classification, 0.33-0.37 for the AO classification and 0.6-0.84 for the Morphologic classification. The intra-observer kappa was calculated for each of the observers (JM, AC, YL) and varied between 0.63-0.73, 0.72-0.77 and 0.73-0.88 for the Neer, AO, and Morphologic classifications, respectively. Conclusion: This study describes a simple and reproducible classification system for isolated fractures of the greater tuberosity: the Morphologic classification. It separates greater tuberosity fractures into 3 distinct and easily identifiable groups: avulsion, split and depression. The depression fracture type is associated with more glenohumeral dislocations than then avulsion and split fracture types combined. However, larger clinical studies are needed to evaluate the impact of these fracture types on functional outcome and on surgical strategies. 174: Infection Rate in Total Shoulder Replacement: Best Practices- Antibiotic cement Danny P Goel, BC; Kevin Roth, US; James R Romanowski, US; Jessica Wells, US; Laurence D Higgins, US; Jon J P Warner, US Purpose: Deep infection of primary total shoulder arthroplasty (TSA) is a rare but potentially devastating complication. The reported prevalence in the literature ranges from 0% to 15.4%. At present, antibiotic impregnated cement is approved for use in second-stage reimplantation after infection. The primary use in TSA is not considered standard of care. This is in contrast to the total hip arthroplasty literature, which has documented a lower deep infection rate following primary arthroplasty. To our knowledge, no report exists of infection rates following primary total shoulder arthroplasty with the use of antibiotic impregnated cement. We hypothesize that the primary use of antibiotic impregnated cement in combination with standard intravenous antibiotics would decrease the rate of infection following primary total shoulder arthroplasty. Method: A single shoulder surgeon’s complete primary TSA experience was retrospectively reviewed. The presence or absence of a post-operative infection was recorded. All patients having undergone primary TSA were included in the study. Previous arthroscopic surgery was not an exclusion criteria. Revision procedures were excluded. Demographic data, operative information as well as post-operative follow up were included. Results: Between 1999 and 2009, 603 TSA were performed by the senior surgeon. A total of 311procedures were primary TSA where 153 were without antibiotic impregnated cement (Group A) and 158 with (Group B)). There was no statistically significant difference in age, operative time or gender distribution between the two groups. At latest follow up, in Group A, 10 (6.5%) shoulders developed a deep infection. In Group B, only 1 (0.6%) shoulder developed a post-operative infection. Neither age, operative side, nor surgical time influenced the development of an infection. Conclusion: The present study retrospectively evaluated every primary TSA performed by a single surgeon at a single institution. Approximately half of these TSAs were performed without the use of antibiotic cement, and half were performed with antibiotic cement. There was a strongly statistically significant relationship between the institution of antibiotic cement and the decrease in infection, p=0.0029. There was no statistically significant difference between the groups in terms of age, sex or operative side. Age, sex and operative side were each completely independent of the development of infection. These findings corroborate outcomes seen in the total knee and hip literature, and support the hypothesis that antibiotic impregnated cement is efficacious in the prevention of deep peri-prosthetic infection in primary total shoulder arthroplasty. 175: Intra- and Inter-Rater Reliability of the Detection of Full-Thickness Tears of the Supraspinatus Central Tendon by Shoulder Surgeons and Musculoskeletal Radiologists John A Grant, US; Bruce S Miller, US; Yoav Morag, US; Jon Jacobson, US; James E Carpenter, US Purpose: Recent evidence suggests that tears of the supraspinatus intramuscular central tendon demonstrated on MRI are more likely to fail with conservative management. The accuracy and agreement in identifying a tear of the supraspinatus intramuscular central tendon on MRI is unknown. The purpose of the current study was to determine the intra- and interrater reliability of detecting a full tear of the supraspinatus central tendon on MRI by orthopaedic shoulder surgeons. Method: The de-identified coronal and sagittal plane MRIs from 40 patients entered into a prospective rotator cuff tear database were independently reviewed by two MSK radiologists in order to identify examples of an intact supraspinatus central tendon, a partial-thickness tear, or a full-thickness tear of the central tendon. MRIs from these patients were randomly sorted and distributed on CD to 16 members of the MOON (Multi-center Orthopaedic Outcomes Network) Shoulder group. Members were also sent an educational presentation including anatomical information about the central tendon and examples of a normal tendon, partial thickness, and full-thickness tear. Members were asked to characterize each patient as having no tear, a partial tear, or a full thickness tear of the central tendon. After a one month interval, the members were sent a new set of CDs with the MRIs randomly reordered and were again asked to diagnose the status of the central tendon. Intra-rater (round 1 vs. round 2) and interrater (within round 1 and round 2 separately) reliability were determined with the kappa statistic. Agreement and inter-rater reliability were also determined between the shoulder surgeons and radiologists. Results: The intra-rater reliability was excellent (0.86 ± 0.11, 95% CI: 0.81, 0.91). The agreement was 93.5% ± 4.8, 95% CI: 91.1, 95.9. Inter-rater reliability for both rounds was also excellent (0.77 & 0.73). The agreement between the shoulder surgeons and radiologists was 92.6% ± 3.9, 95% CI: 90.7, 94.6. The inter-rater reliability between the surgeons and radiologists was excellent (0.84 ± 0.08, 95% CI: 0.80, 0.89). Stratifying partial tears from no tears resulted in lower intra-rater reliability (0.72 ± 0.13, 95% CI: 0.65, 0.79) and inter-rater reliability between surgeons (0.59) and between surgeons and radiologists (0.66 ± 0.09, 95% CI: 0.61, 0.71). Conclusion: The intra-rater reliability and inter-rater reliability between shoulder surgeons, and the inter-rater reliability between shoulder surgeons and MSK radiologists, was excellent for the detection of full thickness tears of the central tendon of the supraspinatus. Since there is agreement among orthopaedic surgeons and radiologists about the condition of the supraspinatus central tendon on MRI, this parameter can be studied as a possible predictor of outcome from conservative treatment for rotator cuff tears. 176: Lesser Tuberosity Osteotomy vs. Subscapularis Tenotomy in Shoulder Arthroplasty: Healing Rates and Fat Infiltration George S Athwal, ON; Peter LC Lapner, ON; Elham Sabri, ON; Kawan Rahkra, ON; Kimberly Bell, ON Purpose: Controversy exists regarding the optimal technique of subscapularis mobilization during shoulder arthroplasty. The purpose of this study is to compare healing rates and fatty infiltration in patients enrolled in a multicentre randomized double-blind study comparing lesser tuberosity osteotomy (LTO) to subscapularis tenotomy (ST). Method: Eighty-seven patients undergoing shoulder arthroplasty were randomized to receive either a LTO or ST. Follow-up CT scans were conducted 12 months post-operatively and radiographic outcome variables included healing rates and subscapularis Goutallier fatty infiltration grade. Results: CT imaging was available in 63% of the cohort. Baseline demographic data did not differ between groups for sex (p=0.72), affected side (p=0.59) or arthroplasty type (hemiarthroplasty or total, p=0.61), however, age differed significantly (ST, 65.3 years, LTO, 70.4 years, p=0.03). The healing rate for ST (96%) and for LTO (90%) did not differ significantly between groups (p=0.62). The Goutallier mean fatty infiltration grade postoperatively for ST (0.58) did not differ significantly from LTO (0.73) (p=0.46). Overall, there was a one-grade increase in fatty infiltration from pre-operative CT to post-operative imaging for the ST group, and a 0.5 grade increase in the LTO group Conclusion: No statistically significant differences were observed in the healing rates or fatty infiltration grades between and the ST and LTO. This trial does not demonstrate any clear difference in radiographic outcomes of one subscapularis management technique over the other. 177: Sensitivity and Specificity of a New Clinical Test for Intra-articular Long Head Biceps Pathology Rachel A Schachar, AB; Kristie More, AB; Ian Lo, AB; Robert Hollinshead, AB; Richard Boorman, AB Purpose: To determine the sensitivity and specificity of a new clinical test, the Saw test, designed to diagnose intra-articular pathology of the long head biceps (LHB) tendon and compare this to previously described clinical tests (Speed’s and Yergason’s). Method: One hundred forty-nine patients from three shoulder surgeon’s practices at the University of Calgary Sport Medicine Centre who consented to undergo arthroscopic shoulder surgery were included. The Saw test is a dynamic test done with the patient lifting up on the examiner's hand with their forearm supinated and elbow flexed 90 degrees. The patient flexes and extends their shoulder, through a 60-degree range of motion (30 degrees of flexion and 30 degrees of extension) while maintaining elbow flexion and forearm supination. This maneuver is designed to maximally load the LHB tendon through a range of motion, within the bicipital groove. A test is considered positive if the patient has pain in the anterior aspect of the shoulder, radiating into the biceps while performing the test. If lateral or posterior pain is elicited, the Saw test is considered negative.Independant examiners were specifically trained by the principle investigator to perform the clinical tests in a standardized manor. The blinded examiners performed the clinical assessment on each patient just prior to arthroscopy. The assessment included the Yergason’s test, Speed’s test, and the new Saw test. Results were recorded on a data collection form and kept unknown to the surgeon. Diagnostic arthroscopy was then performed by the surgeon and included a thorough systematic exam of all shoulder joint structures. Documentation of all joint pathology (including LHB pathology), and procedures performed was made on a form separate from the clinical assessment form. Intraoperative photographs were taken. Arthroscopic findings were considered to be the “true” condition for analysis. Results: One hundred forty-nine patients (87 males and 54 females) were included. Mean age was 49.6 (SD = 14.9). Following arthroscopy intra-articular LHB pathology was found in 93 patients (62.4%), whereas 56 patients (37.6%) had a normal LHB tendon. When examined for presence or absence of LHB pathology, the sensitivity of the specials tests was: Saw – 56%, Speed’s – 52% and Yergason’s – 37%. Specificity was: Saw – 66%, Speed’s – 71% and Yergason’s – 84%. When examined as an indicator for LHB surgical intervention (i.e. debridement, release, or tenodesis), the sensitivity of the special tests was: Saw – 61%, Speed’s – 55% and Yergason’s – 38%. The specificity was: Saw – 60%, Speed’s – 64% and Yergason’s 76%. Conclusion: Our results are consistent with previously published sensitivity and specificity rates for the Speed’s and Yergason’s tests. The new Saw test showed the highest sensitivity in regard to presence or absence of LHB pathology, as well as requirement for LHB surgical intervention. Use of the SAW test may be helpful for surgical decision making in the clinical setting. 178: Subacute Scaphoid Fractures: Factors Predictive of Successful Non-operative Treatment Richard P Nadeau, ON; Nina Suh, ON; Ruby Grewal, ON Purpose: The purpose of this study was to determine factors predictive of successful nonoperative treatment for subacute scaphoid fractures. Method: A departmental radiology database was searched to identify all scaphoid fractures imaged at our institution from 2006 to 2010. A retrospective chart review was conducted for all identified patients. Scaphoid fractures presenting between six weeks to six months from initial injury were included in this study. Their medical records, x-rays, and CT scans were reviewed and followed until union was achieved or non-union was confirmed. Results: Thirty-nine patients met our inclusion criteria with 3 being lost to follow-up. The mean age was 28 (range: 12-65) and 75% were male (n=27). There were 10 proximal pole fractures, 25 waist fractures and one distal pole fracture. The average delay from injury to the initiation of treatment was 12 weeks (range 6-23 weeks). The relative risk (RR) of non-union increased significantly with the presence of an underlying humpback deformity (RR=3) or with sclerosis along the fracture line (RR=2.5). Patients with underlying diabetes also had a greater risk of non-union (RR=2.6). Interestingly, fractures involving the proximal pole (RR=1.3), fractures with cysts identified on CT scan (RR=1) or fractures with 1 to 4 mm of displacement (RR=1.8) did not demonstrate an increased risk of non-union. Seventy-five percent of those that healed successfully with conservative treatment did so by 13.5 weeks. They presented slightly sooner (11 vs. 14 weeks delay to presentation, p=0.05) and required significantly less time in the cast (10 vs. 26 weeks, p=0.004). Conclusion: In the absence of a humpback deformity, sclerosis, and underlying diabetes, scaphoid fractures presenting within six weeks to six months from their initial injury can be successfully treated with casting alone, despite the presence of cystic changes on CT scan. 179: A Prospective Study on Functional Outcome of Percutaneous Epiduroscopic Adhesiolysis Compared to Lumbar Spine Surgery for Treatment of Failed Back Lumbar Syndrome Caused by Fibrosis –Adhesion Ahmed AbdulAmeer Alkhuzai, IQ Purpose: Epidural fibrosis and adhesion seen as common post lumbar syndrome phenomena which contribute to 50%-60% recurrent of the symptoms. Aim of Study: We studied the effectiveness of percutaneous epiduroscopic adhesiolysis in management of fibrosis & adhesion resultant from failed backed lumbar spine surgery compared to second time surgical decompression with surgical excision of the fibrosis of lumbar spinal stenosis. Method: In a prospective comparative study of 44 patients all of them with failed backed post laminectomy syndrome were diagnosed according to magnetic resonance imaging, also according to inclusion exclusion criteria in diagnosis of adhesion with fibrosis, were randomized into two groups .Group A treated by lumbar spine surgery with second time surgical exploration ,decompression and excision of fibrosis compared to the second group B were treated by percutaneous epiduroscopic adhesiolysis through sacral canal under fluoroscopic guide .The caudal epidurogram showed restriction in spread of contrast caused by fibrosis & adhesion then the canal open by irrigation through pressurized saline range from 40 to 80 ml according to the number of the level which were obstructed by fibrosis .Saline used intermittently until the spinal canal open were seen by fluoroscope until complete procedure with adequate adhesiolysis with visualization of the canal opening .At the end of the procedure solutions were used to decrease rate of adhesion .Depomedrol 80 mg 2ml ,Hyaluronate 6ml, 1% 5ml lignocaine injected into canal space. Results: Improvement in contrast filling defects of the epidural space was noticed during treatment by percutaneous epiduroscopic adhesiolysis combined to improvement in pain, short term & long term compared to second time lumbar spinal surgery. Results: In both group A by surgical procedure & B percutaneous epiduroscopic adhesiolysis were noticed significant improvement in the mean of Stanford score and ODI (Oswestry low back disability score) from baseline were at all follow up visit for 24 Months according to sciatica pain (short term less than 6 Months, long term more than 6 Months), Functional outcome, Return back to work, psychological status, Change in narcotic intake, with the general satisfaction rate. Also there were significant statistical differences at 12, 24 Months follow up for both Stanford and ODI Oswestry index between group A and group B revealed high outcome results for group B was treated by epiduroscopic adhesiolysis technique (P- value <0.0001) with minimal complications rate in group B compared to group A. Conclusion: We concluded that percutaneous epiduroscopic adhesiolysis for 2 years follow up are superior to the surgical exploration with excision of fibrosis & second time decompression in treatment of failed back lumbar spinal surgery. 180: Adverse Event Rates of Surgically Treated Cervical Spondylopathic Myelopathy John T Street, BC; Dennis Hartig, BC; Juliet Batke, BC; Michael Boyd, BC; Marcel Dvorak, BC; Charles Fisher, BC; Brian Kwon, BC; Scott Paquette, BC Purpose: In recent years an increased understanding of the natural history of Cervical Spondylopathic Myelopathy (CSM) in parallel with advancements in anaesthetic and perioperative practice have led to broadened surgical indications and more aggressive surgical management. As Canadian demographics, particularly population age and ethnicity, continue to change the surgical burden of CSM will continue to increase. Identification of treatment Adverse Events (AE’s) is critical to objective measurement of surgical utility. We are unaware of any published prospective data specifically quantifying the risk of intraoperative and postoperative adverse eventsfor surgically treated CSM. Method: Data was collected prospectively over a three year period (2008-2010) at our institution on all patients with surgically treated CSM. AE data was collected prospectively during the peri-operative period until discharge using the previously validated SAVES tool. All AE’s were reviewed at a weekly, attending lead, multi-disciplinary adverse events review meeting. 113 patients (81 male, 32 female) with complete SAVES data were identified. Of these patients 43 (38%) were confirmed discharged without an AE being recorded. The remaining 70 patients accrued 105 AE’s in total during their inpatient stay (1.5 AE’s per patient). Results: The most common intra-operative AE’s were hardware mal-position requiring revision (3.3%) and dural tear (1.7%). The most common postoperative AE’s were dysphagia (11.7%), urinary tract infection (11.7%) and postoperative neuropathic pain (10%). Pneumonia was reported in 5% and wound infections in 5%. Conclusion: A significant trend was identified demonstrating increased rate of AE’s in older patients and those with more severe disease prior to surgery. This data should prove helpful in the pre-operative counselling of patients in terms of the absolute risk of AE’s as well as the risk of specific AE’s. 181: Cost-Effectiveness Analysis of a Reduction in Diagnostic Imaging in Degenerative Spinal Disorders Raja Rampersaud, ON; Joanne S M Kim, ON; Joyce Z Dong, ON; Stacey Brener, ON; Peter C Coyte, ON Purpose: Advanced imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI) are highly sensitive, but often non-specific, diagnostic tools. Despite this, CT and MRI are over-utilized in degenerative spinal disorder diagnosis. The purpose of this study was to determine if stronger adherence to the 2001 Ontario guidelines would reduce CT and MRI usage in spinal disorder diagnosis and be cost-effective from the perspective of the Ministry of Health. Method: Diagnostic and surgical data were prospectively collected on 2,046 outpatients who received consultation with the senior surgical author at Toronto Western Hospital, between September 2005 and April 2008. Using these data, we modelled an evidence-based diagnostic triage program (implemented within existing infrastructure) wherein spine-focused clinical assessments by advance practice allied health personnel and plain X-ray imaging would be applied prior to CT and MRI. Incremental costs were the incurred expenses from additional consultations and plain X-rays less the cost savings from the eliminated CT and MRI scans, expressed in 2009 Canadian dollars. Outcomes were expressed as the number of surgical candidates identified per MRI used in diagnosis, reflecting the efficiency of diagnostic imaging. Sensitivity analyses were performed by varying the unit cost of an spine MRI and the proportion of patients who had undergone plain x-ray or CT prior to assessment. Results: The triage program incurred $109,720 from additional consultations and plain X-rays and saved $2,117,697 from eliminated CT and MRI scans, resulting in net cost savings of $2,007,977 for the 31 months of study period or $777,282 per year. In usual care, 0.328~0.418 surgical candidates were identified per MRI whereas in the triage program, 0.736~0.885 surgical candidates were identified per MRI, resulting in over a two-fold improvement in MRI efficiency. The triage program still resulted in net cost savings, even at the implausible extremes of our sensitivity analysis. The triage program was therefore dominating. Applying to “high” volume spine surgeons in Ontario, we estimated that the implementation of the triage program would save the province $24,234,929 per year. Conclusion: Eliminating unnecessary imaging in spinal disorder diagnosis referred to a spine surgeon can save provincial health care significant resources, while providing improved patient access and care. 182: Dynamic Stabilization with an Interspinous Spacer as an Alternative to Arthrodesis for Lumbar Degenerative Disorders Edward P Abraham, NB; Neil Manson, NB; Renee Elliot, NB; Melissa Mckeon, NB Purpose: DIAM (Device for Intervertebral Assisted Motion - Medtronic) is a flexible silicone interspinous spacer providing stability and preserving motion for herniation of the nucleus pulposis (HNP) and providing relief of neurogenic claudication secondary to lumbar spinal stenosis (LSS) with or without degenerative spondylolisthesis (DS). In addition to surgical decompression, arthrodesis is often considered as an adjunct in patients who have central or recurrent HNP and in cases of LSS requiring more extensive decompression. DIAM implantation, performed as a day surgery procedure, was used in cases of HNP and LSS as an alternative to arthrodesis. The purpose of this study was to evaluate the clinical benefit of the use of DIAM in patients undergoing decompression necessary to address symptoms of central or recurrent HNP or LSS who would otherwise have been considered for arthrodesis. Method: Fifty-three patients between 2007-09 with HNP or LSS were considered for decompression and fusion but were offered alternative treatment in the form of decompression and DIAM performed as a day surgery procedure at a single institution. Preoperative Oswestry Disability Index (ODI), SF-36, VAS back and leg scores were compared to values at 1.5, 3, 6, 12 and 24 months post-op. The average follow-up was 3.5 years with a minimum of 2 years. Inclusion criteria consisted of patients with single level pathology and either HNP (central or recurrent) or LSS (with or without DS). Exclusion criteria consisted of patients with multilevel disease and or significant deformity. Statistical significance between pre-op and post-op values were calculated and the need for reoperation and other complications were evaluated. The primary outcome measurement was the ODI and was felt to be clinically significant if a reduction of 30% was observed. SF-36, VAS were also part of the analysis. Results: Forty-nine of 53 (92%) of patients were available for the minimum 2 year follow-up. For the primary outcome, statistically significant improvements were noted for ODI exceeding the minimum 30% improvement at all follow-up intervals post-op (p<0.05). SF-36 , VAS back and leg pain scores also improved at a high level of statistical significance (p<0.05) at all time points compared to pre-op. Three failures were identified necessitating further surgery recurrent HNP in 2 patients (requiring arthrodesis) and sepsis in one patient (implant extraction). There were no complications on the day of surgery necessitating admission to hospital. Significant success was observed in 46/49 (94%) patients based on two year outcomes demonstrating potential longer term survival for the implant and clinical improvement. Conclusion: DIAM with decompression as a day surgery procedure can provide clinical benefit two years post implantation in patients with single level HNP (central or recurrent) or LSS (with or without DS) as an adjunct to decompression where arthrodesis might be considered. Potential cost savings are possible. 183: MIS Lumbar Fusion for Low-grade Isthmic and Degenerative Spondylolisthesis: 2-5 year Follow-up Simon A Harris, ON; Raja Rampersaud, ON Purpose: Minimally Invasive Surgeries (MIS) for lumbar spondylolisthesis (LS) have been shown to be safe and efficacious in the short term but little is know about the intermediate or long-term clinical success. Method: A retrospective cohort analysis was performed on prospectively collected data from patients undergoing one or two-level MIS lumbar fusion for low-grade LS. Surgeries were performed from 2005-2009 by a single surgeon. Global Satisfaction Rating (GSR), Oswestry Disability Index (ODI) and Short Form-36 (SF36) scores were evaluated pre-operatively and post-operatively at six weeks, three, six, 12, 24, 36, 48 and 60 months. Receiver Operating Characteristic curves were used to evaluate SF36 component sub-scores at two years with ‘success’ anchored to GSR. For each SF36 component, the two-year score and the two-year Norm-Based Score (NBS; age and sex matched to normal Canadian equivalents) were analysed. Results: 66 patients where at, or over, two-year follow-up. The mean age at surgery was 54 years, 44.2% female and mean follow-up was 3.58 years. Baseline ODI scores (n=66, mean 38.32% [95% CI 42.01-33.99]) continued to improve until two years post-operative (n=66, mean 17.24% [95% CI 13.26-20.80]) and are maintained to five years (n=27, mean 16.81% [95% CI 10.03-23.60]). The ROC curve analysis of two-year SF36 component scores identified Physical Functioning (Cut-Off Score 50; Area Under Curve 0.89; Sensitivity 0.78; Specificity 0.84) and Bodily Pain (COS 41; AUC 0.88; Sensitivity 0.77; Specificity 0.86) as the strongest correlates of satisfaction. The COS for the two-year SF36 NBS components that correlated best with satisfaction, were consistently one standard deviation below their Canadian age and sex-matched equivalents. Conclusion: The benefits of MIS lumbar fusion for low-grade spondylolisthesis are maintained for two to five years. Despite SF36 component scores below their mean Canadian age and sex-matched equivalents, 85.7% of patients were satisfied with their outcome. 184: Preventions of Technical Complications During Retrorectal Presacral Approach for Lumbosacral Axial Instrumentation Kalliopi Alpantaki, GR; Pavlos Katonis, GR; Alexander Hadjipavlou, GR; George Vastardis, GR; Nick Benardos, GR Purpose: This is prospective study and literature review which aims to quantify the risks and the complications associated with AxiaLIF in a series of 29 patients and to highlight the reported complications in the literature. Method: The complications in a series of 29 patients treated with AxiaLif were analyzed. Also the reported complications in the literature until October 2010, was examined in order to establish technical guidelines for prevention of surgical pitfalls Results: Fusion rate in the present series was 92%.Complications included presacral hematoma: 1 (3,5%).Symptomatic subsidence, occurred in the stand alone group, resulted in foraminal stenosis and radiculopathy in two patients (7%) and back pain in one (3,5%). One patient (3,5%) developed painful radiolucent halo around the rod in a spondylolytic case which resolved after transpedicular instrumentation. Literature review revealed only 23 manuscript and 53 abstracts, all retrospective level IV studies. According to FDA reports the most dreadful complication was rectal perforation in 55 patients. The rest were some asymptomatic subsidences, posterior graft extrusion (1,1%- 3,3%), hematoma (1,8%), implant radiolucency (3,9%) and insignificant number of ureteral and vascular injuries. Fusion rates ranged from 68% to 100%. Conclusion: AxiaLIF is a novel truly minimally invasive technique not requiring blood transfusion and can be safely performed as a day surgery. Retroperitoneal hematoma, ureteral and vascular injuries can be avoided by respecting the regional anatomical landmarks as guided by accurate fluoroscopy. Only expanding hematoma may be drained. Bowel perforation can be prevented by gently sweeping away the rectum from the sacrum before inserting the guide probe. 185: Prospective Analysis of Adverse Events in Surgical Treatment of Degenerative Spondylolisthesis Adrienne M Kelly, BC; Juliet Batke, BC; Michael Boyd, BC; Marcel Dvorak, BC; Charles Fisher, BC; Brian Kwon, BC; Scott Paquette, BC; John T Street, BC Purpose: Surgical literature traditionally focuses on outcomes and comparisons of specific procedures. There is a paucity of data on outcomes and adverse events (AEs) in the context of the presenting diagnosis. Such condition-specific AE information would greatly facilitate informed consent. Specific intra- or post-operative AEs independently associated with a diagnosis of degenerative spondylolisthesis (DS) have never been examined, and the AE data that is available, by virtue of the methods of identification, are substantially underreported. This study prospectively assesses the AE profile of a cohort of surgical-treated patients with a primary diagnosis of L4-5 DS, with the secondary aim of identifying risk factors that correlate with those adverse events. Method: Prospective AE data using the SAVES tool on patients surgically treated for L4-5 DS between 1 January, 2009 and 31 December, 2010 was analysed and compared to outcomes reported in the Spine Patient Outcomes Research Trial (SPORT). Results: Of 1444 surgical cases, 97 (6.7%) had the diagnosis of DS, and of these, no complications were seen in 49.5%. The total intra- (10.3%) and post-operative (73.2%) complication rate was 83.5%, suggesting that some of the 50.5% of patients with complications had more than one AE each. The most common intra-op AEs were bone/hardware issues 7.9%, and dural tears 6.5%. The most common postoperative AEs were UTI 14%, delirium 6.5%, surgical site infection 5.2%, and neuropathic pain 5.2%. SPORT reported substantially lower complication rates: an adverse-event-free rate of 87% intra-operatively and 69% postoperatively, with total complication rates at four years of follow-up of 13% each intra- and postoperatively. Conclusion: This prospective analysis highlights a notable discrepancy in AE rates compared to published literature not specifically designed to look at AEs. Further distillation of this data may demonstrate diagnosis-specific correlations with specific types of adverse events. 186: Radiostereometric Analysis (RSA) Evaluation of One-level Lumbar Fusions Using Trabecular Metal Intervertebral Cages Over Two years William Oxner, NS; Elise Laende, NS; Allan Hennigar, NS; James Edwards, NS; Michael J Dunbar, NS Purpose: Quantitative assessment of the success of spinal fusion remains a significant challenge for orthopaedic surgeons. Radiostereometric analysis (RSA) can detect the presence or absence of mobility between fused intervertebral segments with a high degree of precision. The purpose of this study was to determine the success of a posterior lumbar interbody fusion using Trabecular Metal™ Cages (Zimmer Spine, Minneapolis MN) augmented with pedicle screw instrumentation with RSA. Method: Eighteen patients were recruited using strict inclusion criteria. During surgery, six tantalum markers, 0.8mm in diameter, were inserted into the two vertebrae at the fused level. Using a calibration box, stereo RSA radiographs were taken within four days post-operatively and then at follow-up exams at six weeks and three, six, 12 and 24 months following surgery. At the follow-up exams RSA radiographs were taken with patients first in a supine position and then in a sitting position to determine the movement between the fused segments at each time point. Results: Fusion assessment shows relative motion between the two vertebrae, with average total motion of 0.57 mm, 0.94 mm, 0.68 mm, 0.52 mm, and 0.65 mm at six weeks, three months, six months, 12 months, and 24 months respectively when comparing supine to seated positions of patients. The precision of the RSA method for this application was assessed from double RSA clinical exams of all subjects and found to be 0.11 mm for total motion. Conclusion: The leveling off of the relative motion between the fused segments after three months suggests successful fusion has been achieved with the Trabecular Metal™ Cages augmented with pedicle screw instrumentation. While RSA analysis is challenging, the resolution achievable makes RSA a superior measurement method to conventional radiography for assessing spinal fusions. 187: Traditional Open versus Minimally Invasive Decompression and Fusion of the Lumbar Spine: A Retrospective Analysis Neil Manson, NB; Melissa McKeon, NB; Edward Abraham, NB; Renee Elliott, NB Purpose: Minimally invasive surgical (MIS) techniques offer theoretical advantages over traditional midline (OPEN) techniques for lumbar decompression and fusion procedures. These advantages have yet to be adequately substantiated in the literature via direct comparison. Therefore the purpose of the study is to identify advantages and pitfalls of MIS versus OPEN techniques in the management of lumbar degenerative pathologies via decompression and fusion. Method: Retrospective review of a prospective database from September 2006 to November 2009 identified 187 patients receiving single level lumbar decompression and fusion procedures. Of the 187, 141 (OPEN = 90, MIS = 51) met the inclusion criteria and were included in the analysis. Pre-operative (i.e. patient demographics, disability and pain scores), intra-operative (i.e. blood loss, surgical time, complications), and post-operative (i.e. complications, revision rates, disability and pain scores) data were analyzed using an ANOVA (p > 0.05) to detect significant differences between groups. Results: Both surgical groups demonstrated statistically similar preoperative demographics (age, gender, BMI, ODI, VAS Leg and Back). The OPEN procedure demonstrated statistically greater blood loss before (519.6 vs. 259.4ml) and after (377.5 vs. 232.2ml) Cell Saver blood return with significantly shorter operative time (124.1 vs. 194.4min). Otherwise, all other measures were similar. Intra-operative and post-operative complications, hospital stay, and revision rates were equal. At one year follow-up, both groups displayed a similar drop in ODI (OPEN: 50.7 to 29.3%, MIS: 55.7 to 39.6%), VAS Leg (OPEN: 7.4 to 4.3, MIS: 7.3 to 4.1), and VAS Back (OPEN: 7.8 to 3.6, MIS: 7.5 to 4.5). Conclusion: Specific surgical approach techniques may offer certain advantages to optimize outcomes. Ultimately, appropriate technique at the level of the spine to provide decompression and stabilization should ultimately dictate surgical success. Future work should focus on preoperative decision making, operative challenges, and objective biomechanical measures to assure similarity between techniques. 188: Wiltse versus Midline Approach for Fusion of the Lumbar Spine: A Prospective Cohort Comparison Zhi Wang, BC; Christian DiPaola, BC; Charles Fisher, BC; John T Street, BC Purpose: The Wiltse bilateral muscle splitting approach represents an alternative to traditional midline approach to the lumbar spine for decompression and fusion of degenerative conditions. When comparing Wiltse to midline approaches our primary null hypothesis was that there is no difference in rates of surgical site infection (SSI). The secondary null hypothesis was that there would be no difference in the rates of secondary surgery within . Method: Between July 2005 and June 2008 we identified 183 Wiltse cases and 53 midline cases of single or two level lumbar fusion, matched for age, gender, co-morbidities, number of levels fused and history of previous surgery. There was a minimum of 3 year follow-up and statistical analysis was performed using Fishers exact test and one sided p values. Results: Mean age (p=0.02), length of hospital stay( p=0.008) and intra-operative blood loss (p<0.001) were significantly lower in the Wiltse group. There was no difference in the mean length of the surgical procedure(p=0.689). In the Wiltse group there was a greater use of bone graft alternatives, in particular BMP (p=0.005). The rate of SSI was 1.9% Wiltse versus 7.5% Midline (p=0.11). The rate of second surgery within 3 years was higher in the Midline group (p=0.025). Delayed wound complication (23 vs 0%) and adjacent segment failure (10% vs 0%) higher in the Midline group, while pseudarthrosis was higher in the Wiltse group (25% vs 7%). Conclusion: The Wiltse approach is a viable alternative for 1 or 2 level lumbar arthrodesis with lower rates of SSI and lower blood loss. Secondary surgery for junctional failure is less common, but pseudarthrosis is more common. 189: A Biomechanical Evaluation of the Dynamic Sling Effect of the Latarjet Procedure: Does It Improve Shoulder Stability? Joshua Giles, ON; Harm W Boons, NL; Kenneth Faber, ON; Ilia Elkinson, NZ; Louis Ferreira, ON; James Johnson, ON; George S Athwal, ON Purpose: The conjoint tendon, transferred during the Latarjet procedure, is thought to provide a stabilizing sling effect; however, the significance of this mechanism is unknown. The purpose of this in-vitro biomechanical study was to evaluate the effects of the Latarjet procedure, with and without conjoint tendon loading, on stability and range of motion (ROM). Method: Cadaveric shoulders (n=8; avg. age: 78 yrs) were tested on a custom simulator capable of loading eight muscle groups. All testing conditions (intact, 30% anterior glenoid defect, and Latarjet with and without conjoint loading) were performed on each specimen as repeated measures. Each condition was tested in two levels of elevation (0 and 90°) with conjoint loading (0 and 10N) randomized. Passive internal/external rotation ROM, joint dislocation, and shoulder stiffness were evaluated. Joint stiffness was tested in neutral and 60o of external rotation using an anterior 70N load. Humeral internal/external rotation ROM was determined using a predefined applied torque. Results: All 30% glenoid defects caused dislocation in abduction and external rotation. The loaded Latarjet prevented dislocation in all specimens, while the unloaded stabilized 6 of 8. In abduction external rotation, there were no significant differences in stiffness between loading states (p=0.176); however, the unloaded Latarjet did trend towards a decreased stiffness as compared to intact (p=0.081). In adduction, there were no significant differences in stiffness between intact and the loaded Latarjet (p≥0.228); however, in neutral rotation the unloaded Latarjet (p=0.015) and the 30% defect (p=0.011) had significantly less stiffness than intact, and were nearly equal. No differences were found in ROM in adduction; however, in abduction the loaded Latarjet significantly reduced ROM compared to unloaded (29.03±15.16, p=0.014). Conclusion: A dynamic sling effect of the conjoint tendon is thought to enhance stabilization. This study found that the loaded Latarjet prevented dislocation in 25% more cases than unloaded and thus can be said to influence joint kinematics. The unloaded Latarjet had minimal effect on stiffness, especially in neutral rotation where it was essentially equal to the 30% defect and significantly less than intact. In contrast, the loaded Latarjet increased joint stiffness; however, the increase was not statistically greater than unloaded. An important observation from this data is that stiffness improved during loaded external rotation due to increased conjoint wrapping around the humeral head. Conjoint loading caused significant restriction in ROM compared to the 30% defect and unloaded but not compared to loaded intact indicating that the sling effect is unlikely to limit motion beyond the physiologic level. These findings indicate that glenohumeral stability is improved by conjoint tendon loading, thus supporting the importance of the sling effect. Stability parameters, however, are not fully restored to the intact level. 190: An In-Vitro Biomechanical Comparison of the Classic and Congruent Arc Latarjet Procedures Joshua Giles, ON; Harm Boons, NL; Ilia Elkinson, NZ; Kenneth Faber, ON; Louis Ferreira, ON; James Johnson, ON; George S Athwal, ON Purpose: The Latarjet procedure is an effective treatment for complex anterior shoulder instability and has two variants. The Classic Latarjet transfers the coracoid directly to the anterior glenoid while the Congruent Arc rotates the coracoid 90° so that its undersurface is flush with the glenoid. The purpose of this in-vitro biomechanical study was to compare the range-of-motion (ROM) and stability of these two techniques. Method: Eight cadaveric forequarters were mounted on a custom simulator that applies loads independently to eight muscle groups including the conjoint tendon. Repeated measures were used to evaluate test conditions of intact, 30% glenoid defect, and Classic and Congruent variants. Outcome measures of internal/external ROM, joint stiffness, dislocation, and translation were evaluated in 0o and 90o combined abduction. Stiffness was tested in neutral and 60o external rotation using an anterior 70N load. ROM was determined using a predefined clinical torque. Results: Stiffness in abduction external rotation was significantly reduced in the defect as compared to intact (21.9±13.0N/mm, p=0.012), Congruent (7.0±4.2N/mm, p=0.015), and Classic (7.3±1.4N/mm, p<0.001) conditions. In all test positions, intact was not significantly different from the two variants, and they did not significantly differ from each other (p≥0.102). All specimens dislocated with a defect in abducted neutral and external rotation. The Classic variant resulted in 1 specimen dislocating in abduction neutral rotation, and 0 in external rotation. The Congruent variant effectively prevented dislocation in all positions. In adduction, no significant differences in ROM were observed (p>0.05). In abduction, ROM was significantly reduced after Classic and Congruent transfers as compared to the defect (25.8±18.0°, p=0.032; 22.2±16.7°, p=0.041) but did not differed from intact or each other (p≥0.282). The Congruent technique in abduction external rotation was the only configuration to produce significantly greater translation than the Classic technique (3.5±2.9mm, p=0.013). Conclusion: The Classic Latarjet procedure is clinically proven; however, the introduction of the Congruent Arc variant has necessitated evaluation of the comparative effects of the two. It was found that both techniques achieved a significant increase in joint stiffness in the critical position of clinical apprehension (abduction external rotation) but neither repair produced a significantly greater effect. Both techniques were able to eliminate dislocation in all cases except for one treated with the Classic; however, notably, the Congruent variant allowed significantly greater translations due to the increase in glenoid width. ROM data confirmed that neither variant caused significant changes in motion compared to intact; however, both did restrict motion compared to the 30% defect, confirming the Latarjet’s stabilizing effects. Therefore, the two Latarjet techniques do not significantly differ from each other in the parameters tested. 191: Bristow Procedure for Anterior Shouder Instability- Bone Block or Tension-band Effect ? A Cadaveric Study Maxime Côté, QC; Stéphane Pelet, QC; Réjean Cloutier, QC; Marie-Pier Beaulieu, QC Purpose: Anterior shoulder dislocation can lead to instability in up to 35% of patients and surgical treatment is then recognized. Bristow procedure was described in 1950 and demonstrates good clinical results on stability. Bristow's efficacy is based on two hypothetical mechanisms (not yet demonstrated), either 1) Bone block (coracoid process) or 2) Tension band (conjoined tendons or subscapularis). The goal of this study is to demonstrate the individual role of each mechanism. The hypothesis states that only the bone block is responsible for the stability of this procedure. Method: 8 fresh-frozen cadavers (16 shoulders) were operated in the Laboratoire d'Anatomie at Laval University in Quebec by the same shoulder surgeon. For each shoulder, through a deltopectotal approach, a soft-tissue Bankart lesion was realised and instability confirmed with fluoroscopy. A Bristow procedure was realised according to the original descritpion: tip of coracoid process with conjoined tendons inserted at the front of the glenoid-anteroinferior aspect- through a longitudinal window in the inferior aspect of the subscapularis. The head displacement/glenoid length ratio (HD/GL) was measured on an axillary view at three times: 1) Before Bristow procedure 2) After Bristow procedure 3) After cutting the conjoined tendons from the coracoid process. The force applied was constant during all the procedure. Descriptive statistical analysis with Fisher exact test was done. Results: Bristow procedure is efficient on stability with a significantly lower HD/GL ratio from 30% (95%CI:25-35;p<0,05). After cutting the conjoined tendons, 93.8% of shoulders demonstrated no modification of the HD/GL ratio (p<0,05). This proves that Bristow procedure is effective only through a bone block mechanism. Conclusion: This cadaveric study is the first study at our knowledge that tried to demonstrate the real mechanism of stability with the Bristow procedure. We demonstrated that the main effect is confered through a bone block mechanism and that the role of the conjoined tendons or subscapularis muscle is not relevant on the stability after this procedure. These results fit with other published studies demonstrating the absence of EMG activity in patients with Bristow procedure. Even if this study is limited through its cadaveric design, the great number of fresh-frozen cadavers and the limitation of bias allow to state significant comclusion. The Bristow procedure is effective only through a bone block mechanism. 192: Coracoid Process Autograft Incorporation Following Latarjet Transfer for Anterior Shoulder Instability Danny P Goel, BC; James R Romanowski, US; Jon JP Warner, US Purpose: Advanced glenoid bone loss or recurrent shoulder dislocation following soft tissue procedures for anterior shoulder instability often require osseous reconstruction. For patients undergoing a Latarjet procedure, successful incorporation of the transferred bone is considered a critical element for reestablishing shoulder stability. Traditional clinical measures of a healed bone graft are based on symptoms of pain, stability, and radiographic parameters. Osseous union as evaluated by CT scans has not been reported in the literature. Method: Fifty-one consecutive patients (Age 16-68 yo; avg: 36 yo) undergoing a coracoid process transfer for large glenoid defects or recurrent shoulder instability following failed soft tissue procedures were identified. A retrospective review found twenty-six patients (twentyeight shoulders) having postoperative CT scans available within a single institution. Six patients (23%) were female and twenty were male (77%). Surgical procedures were performed between 2005-2009 by a single surgeon. The CT scans were obtained 2.5-37 months (avg. 6.9 ± months) after surgery and were reviewed by two fellowship trained shoulder surgeons for bony union of coracoid process to the native glenoid. Results: : For patients with CT scans performed ≥6 months after surgery (10 shoulders), only 1 glenoid (10%) failed to show signs of cortical bridging. Bony union was found in 90% (9/10) of patients. There was a statistical significance between union and lack of union for shoulders >6 months postop (p=0.021). For patients with CT scans performed 4 – 5.9 months after surgery (15 shoulders), six glenoids (40%) did not display cortical bridging. Nine shoulders (60%) displayed coracoid union to the glenoid during this interval. There was no statistical significance within this interval (p=0.607). For patients with CT scans performed from 2 - 3.9 months postoperatively (3 shoulders), two glenoids (67%) failed to show evidence of cortical bridging between the coracoid and glenoid (p=1.00). One shoulder (33%) showed bony union. When comparing 2-5.9 months with >6 months, there was a statistically significant decrease in lack of union (p=0.039). When comparing union rates between intervals, statistical significance was found between 2-3.9 months and 4-5.9 months (p=0.021) and between 2-3.9 months and 6+ months (p=0.021). The interrater reliability was found to be Kappa = 0.916 (p<0.001), 95% CI (0.753, 1.079). One shoulder (4%) demonstrated graft osteolysis. Conclusion: Coracoid process transfer results in reliable union demonstrated on CT scans in 90% of patients when studied greater than 6 months from the time of surgery. Reliable osseous integration was found to be less evident during early follow up (< 6 months). Increasing rates of bony incorporation were evident with advanced time from the date of surgery and this study suggests that CT scan radiographic evaluation of bony union should be delayed >6 months to optimize recognition of osseous fusion. 193: Could Posterior Capsule Tightness be a Contributor to Anterior Shoulder Instability? Ryan T Bicknell, ON; Gabriel Venne, ON; Sima Zakani, ON; Erin Janine Smith, ON; Brian Rasquinha, ON; Randy E Ellis, ON Purpose: Anterior shoulder instability is a common injury observed in young athletes, such as throwing athletes, who perform repetitive overhand movement accompanied by forceful followthrough. Most cases typically respond well to physiotherapy, however chronic instability may require surgical intervention. Surgical treatments are aimed at tightening the anterior capsule, implying that the instability is caused by abnormal anterior laxity; yet, there are still cases which fail to improve following tightening. Our hypothesis is that anterior instability may be due to capsular imbalance, particularly posterior capsular tightness even in the absence of anterior laxity. The objective is to investigate the effect of posterior capsule tightness on anterior translation of the humeral head. Method: Four in-vitro trials were performed using cadaver shoulders consisting of a complete scapula, entire upper limb, and intact rotator cuff. Three specimens were fixed while one was fresh-frozen. The scapula and humerus were instrumented with opto-electronic motion capture equipment so that precise position information could be recorded for analysis. Each shoulder was moved passively through a series of 14 movements comprising various combinations of abduction/adduction, flexion/extension, internal/external rotations and anterior/posterior movements. The entire movement series was repeated for 5 different soft tissue states: rotator cuff intact, rotator cuff removed (capsule intact), and induced posterior capsular plications of 5mm, 10mm and 15mm. The maximum anterior translation of the humerus was computed for each movement in each soft tissue state. Results: There was significantly higher anterior translations observed in the fresh-frozen compared to the fixed specimens. The mean maximum anterior translation was 14.2mm. Maximum anterior translation was observed primarily in motions involving abduction/adduction with internal rotation, and abduction with external rotation, i.e. common throwing motions. No significant difference in anterior translation was found with removal of the rotator cuff intact (p>0.05). No significant difference was found at 15mm of induced tightening (p>0.05), while anterior translation was significantly higher with 5mm and10 mm of tightening (p<0.05). Conclusion: This study suggests that posterior capsule tightness contributes to anterior motion of the humeral head and may be a factor in anterior instability. The implications of these findings may advocate posterior capsule stretching physiotherapy or a posterior capsular surgical release as potential treatment therapies for anterior instability. 194: Does Subacromial Cortisone Injection Influence the Outcome of Non-Operative Treatment for Chronic Full-Thickness Rotator Cuff Tears? Richard Boorman, AB; Kristie D More, AB; Kelly Brett, AB; Robert M Hollinshead, AB; Ian KY Lo, AB; Preston Wiley, AB Purpose: A comprehensive non-operative treatment program for patients with chronic fullthickness rotator cuff tears has been developed and studied at our clinic. The program consists of many different treatment modalities including physical therapy, graduated home based exercises, cortisone injections, anti-inflammatory medications, and activity modification. Our objective was to determine if subacromial cortisone injection influenced the outcome of the comprehensive, non-operative treatment program for patients with chronic full-thickness rotator cuff tears. Method: One hundred patients were enrolled in a prospective, non-operative rotator cuff study at a tertiary based referral center. Patients were seen by a sport medicine physician at baseline and 6 weeks; by a physical therapist at baseline and at two-to-four weeks; and by a sub-specialized shoulder surgeon at 3 months. All patients underwent a home based program of stretching and strengthening exercises taught to them by the physical therapist. Adjunct treatments such as cortisone were prescribed at the discretion of the treating sport medicine physician at baseline or 6 weeks, or by the surgeon at 3 months. Patients were defined as “successful” or “failed” at the three month appointment by the surgeon. Successful patients had improved to the point that surgery was no longer an appropriate treatment option, whereas failed patients consented for surgery. The number of patients who had a cortisone injection during the three month course of the study was evaluated to determine if cortisone influenced outcome. Results: Overall, 75 out of 100 patients (75%) were successful, while 25/100 (25%) failed the non-operative treatment program. In total, 31 patients (31%) had a cortisone injection, while 69 (69%) did not. Of those that had a cortisone injection, 19 (61%) went on to be successful with the non-operative treatment program, while 12 (39%) failed the non-operative program. Of the total number of successful patients 19/75 (25.3%) had a cortisone injection. Of the total number of failed patients 12/25 (48%) had a cortisone injection. Chi-square analysis examining the influence of cortisone on overall outcome shows a significant difference between groups (p = 0.03). Conclusion: Cortisone was used significantly more frequently in patients who ultimately still failed the comprehensive non-operative treatment program, despite the fact that 61% of patients who received a cortisone injection had a successful outcome. 195: Injury to the Suprascapular Nerve During Arthroscopic Superior Labral Repair Martin J Bouliane, AB; Lauren Beaupre, AB; Nigel Ashworth, AB; Robert Glasgow, AB; Jeffery Bury, AB; Robert Lambert, AB; Anelise Silveira, AB; David M Sheps, AB Purpose: A recent cadaveric shoulder study has reported that standard techniques for arthoscopic superior labral repair can put the suprascapular nerve at risk due to drill and anchor perforation of the medial glenoid wall. The purpose of this study is to prospectively evaluate the clinical risk of suprascapular nerve injury during arthroscopic superior labral repair in smaller patients as this population appears to be at particular risk for medial wall perforation. Method: Between March 2008-April 2011, 12 patients under a height of 178 cm undergoing arthroscopic superior labral repair were prospectively enrolled. Intra-operative data collection included portal location, labral tear characteristics, number, location and type of anchors, and surgeon impression of the presence or absence of medial glenoid wall perforation. Nerve conduction studies were obtained post-operatively to assess suprascapular nerve function. A post-operative Magnetic Resonance Image (MRI) was performed and read by a trained musculoskeletal radiologist to document perforation of the medial glenoid wall and the distance from the anchor to the suprascapular neurovascular bundle. DASH scores were recorded pre and 6 months post-operatively. Results: Medial wall perforation by suture anchors occurred in five of 12 patients (42%), with four patients having a single perforation and one patient having two perforations. Eight of 38 (21%) anchors drilled into the superior half of the glenoid perforated the medial wall while six of 20 (30%) anchors inserted into the postero-superior quadrant of the glenoid perforated the medial wall. Perforations occurred through both the portal of Wilmington and the anterosuperior portal. The distance to the suprascapular neurovascular bundle from the perforating anchors ranged from 0-4 mm. Nerve conduction studies revealed subclinical signs of an incomplete nerve injury in one patient. DASH scores improved an average of 30 points in these patients. Conclusion: Using standard arthroscopic techniques to repair the superior labrum, medial wall perforation by suture anchors is common in smaller patients. Further, the suprascapular nerve can be injured if perforation occurs. 196: Latissimus Dorsi Tendon Transfer for Massive Rotator Cuff Tears: A Cadaveric Study Patrick D G Henry, ON; Timothy Dwyer, ON; Michael D McKee, ON Purpose: The latissimus dorsi tendon transfer (LDTT) for the treatment of massiver rotator cuff tears is a technically difficult procedure. Releasing the tendon insertion can be hazardous as several vital neurovascular structures are near to the dissection plane. A second critical step involves obtaining adequate length, which involves extensively releasing the muscle belly from its local soft–tissue attachments. We performed a cadaveric study with twelve shoulders to further delineate the anatomic features of the latissimus dorsi muscle to enhance the safety and efficacy of transfer. Method: Twelve shoulders embalmed with a modified Thiele method were obtained. A deltopectoral dissection allowed visualization of the lat dorsi tendon insertion. Using a calibrated digital ruler, measurements were made from the superior and inferior tendon edges to the axillary nerve, radial nerve, brachial artery, profundus brachialis artery, and posterior circumflex artery. Measurements were performed with the arm at the side, and in the forwardflexed/internally-rotated position. A standard LDTT surgery was then performed. With the transferred tendon under a standardized tension of 2 lbs, sequential measurements from the tendon edge to a reference point on the humeral head were made to assess the effect of two lengthening procedures: The standard release (involving a 10 cm posterior skin incision), and an extensile release (25 cm incision). Results: With the shoulder forward flexed/internally rotated (surgical position), the distance from the superior tendon edge to the radial nerve, brachial artery, axillary nerve, and posterior circumflex artery were measured to be 30mm, 28mm, 21mm, and 15 mm respectively. The distance from the inferior tendon edge to the radial nerve, brachial artery, and profunda brachialis artery were measured at 17mm, 22mm, and 14mm respectively. Moving the arm from a flexed/internally-rotated position to neutral decreased these distances , which was statistically significant in 3 of the 6 measurements. When performing the release procedures, an average of 15mm of length (range: 8 to 21mm) was gained from a standard release, and an additional 17mm (range: 10 to 38mm) was gained with an extensile release. In no specimens did the neurovascular pedicle limit the transfer through a tethering effect. Conclusion: Cadaver tissue demonstrates consistently measureable safe distances from the tendon edge to the vital neurovascular structures during the tendon release portion of latissimus dorsi tendon transfer surgery. These distances are increased by forward flexing and internally rotating the shoulder, and can be used as a guide during tendon release through the posterior approach. The standard muscular release provides an average of 15mm of length to the musculotendinous unit, and an additional 17mm can be gained by performing an extensile release. The pedicle does not act as a tether to limit the transfer length. These findings can enhance the safety and efficacy of LDTT surgery. 197: Short Term Complications of the Latarjet Procedure Danny P Goel, BC; Anup Shah, US; Robert B Butler, US; James R Laurence D Higgins, US; Jon J P Warner, US Romanowski, US; Purpose: While results of Latarjet procedure have been reported previously there is little written regarding early complications of this procedure. Our purpose was to report our experience with Latarjet for instability and highlight the initial complications that may occur following this procedure. Method: Between January 2005 and January 2010, 47 patients (48 shoulders) underwent the Latarjet procedure for anterior shoulder instability. All patients had some element of anterior glenoid rim bony deficiency or failed prior soft-tissue Bankart repair. Minimum follow up was 7 months. Results: 43 patients were available for follow-up. The overall complication rate was 25% (12/48). Complications were divided into three groups: infections, instability, and neurologic injury. We identified three patients (3/48, 6%) who developed a superficial infection that resolved following irrigation and debridement and administration of antibiotics for three to four weeks. Four patients (4/48, 8%) developed recurrent instability. Two patients failed within a year and the other two failed at 19 and 42 months postoperatively. Five patients (5/48, 10%) were identified who had neurological injury. Of these, two involved the musculocutaneous nerve, one involved the radial nerve, and two involved the axillary nerve. The three patients with musculocutaneous and radial nerve injuries were sensory neuropraxias that fully recovered within two months. The two with axillary nerve dysfunction have persistent sensory disturbances and one patient has residual weakness that has not yet recovered fully. Conclusion: An overall complication rate of 25% (12/48) is higher than reported in the literature. While most of these completely resolved, several patients have residual neurologic symptoms. Patients should be made aware of the risk for complication with this procedure though most will be temporary problems. 198: The Biomechanical Strength of Classic and Congruent Arc Latarjet Constructs Joshua Giles, ON; Gabor Puskas, CH; Mark Welsh, ON; George S Athwal, ON; James A Johnson, ON Purpose: The Classic and the Congruent Arc Latarjet are two techniques of coracoid transfer which differ only in graft orientation. The Classic method orients the lateral coracoid surface flush with the glenoid, while the Congruent method does so with the inferior surface. However, the biomechanical parameters of these two reconstructions are unknown. Hence, the objective of this study was to compare these two constructs by quantifying load transfer and graft displacement. Method: Eight shoulders (four pairs) were tested using a materials testing machine. Specimens were tested in their intact condition and following paired randomized Classic or Congruent Latarjet reconstruction of a 25% anterior glenoid bone defect. The glenoid rim was subjected to 100 cycle sets (50, 100, 150 and 200N at 1Hz) of loading using the humerus oriented in 30° of abduction and with the force oriented 30° anterior. Subsequently, load was increased until graft failure (10mm displacement). Biomechanical outcome parameters of strain, recorded at the anterior glenoid vault, used to assess load transfer, and displacement used to assess stability were quantified. Results: Above 150N the Congruent Arc produced a significant increase in humeral displacement compared to intact (>3.8mm, p≤0.045). In contrast, the Classic Latarjet produced no significant differences in displacement at any load (p≥0.278). The Classic Latarjet allowed significantly less displacement than the Congruent above 150N (>3.2, p≤0.033). A significant difference (p=0.031) in failure load was recorded (Classic: 701.1±83.4N, Congruent: 435.9±166.9N). Strain significantly increased during 100N loading with the Congruent Arc compared to intact (251±142µε, p=0.038). There were no differences in strain when comparing the reconstructions (p≥0.176), intact shoulder pairs (p≥0.148), or intact shoulders and their subsequent Classic Latarjet reconstructions (p≥0.246). Conclusion: In addition to the Latarjet’s stabilizing effects, it is also important to understand the construct strength and resulting load transfer. We found that the Classic Latarjet produced displacements similar to intact and thus possesses sufficient strength to maintain native humeral head kinematics. Conversely, above 150N the Congruent technique produced significantly larger displacements than the Classic and the ultimate failure load was significantly inferior. The Classic Latarjet effectively reestablished intact load transfer as no differences in strain were observed; however, the Congruent Arc did alter load transfer patterns but only significantly at one loading level. This alteration was expected as the orientation of the coracoid in the Congruent technique widens the glenoid greater than the 25% defect created. This discrepancy in glenoid width may also lead to abnormal kinematics. The differences observed in graft displacement and glenoid strain demonstrate a substantial variance in strength between the Classic and Congruent Arc constructs. 199: Assessment of the Incremental Cost-utility of Surgery Compared to Failed Medical Management for the Treatment of Hip, Knee and Spine Osteoarthritis Raja Rampersaud, ON; Peggy Tso, ON; Kevin Walker, ON; Brendan Eagen, ON; Nizar Mahomed, ON; Peter C Coyte, ON Purpose: The demand for surgery for osteoarthritis (OA) of the hip, knee, and spine continues to rise. While total hip arthroplasty (THA) and total knee arthroplasty (TKA) have been widely accepted as cost-effective procedures, the cost-effectiveness of spine surgery – decompression (D) and decompression with fusion (DF) – for the treatment of degenerative conditions remain controversial. The primary purpose of this study was to directly assess and compare of the cost-effectiveness of end-stage surgical treatment of hip, knee and spine (onetwo level-focal spinal stenosis with or without spondylolisthesis) osteoarthritis. Method: An incremental cost-utility ratio (ICUR) analysis comparing D and DF to THA and TKA, the perspective of the provincial health insurance system was based on outcomes from a prospective observational matched-cohort study and retrospectively collected costs. Patient outcomes were measured using SF-6D utility scores derived from the short-form (SF) 36 over a five-year follow-up period. Utility, abased on five-year data was modeled over the lifetime and quality-adjusted-life-years (QALY) were determined. Surgical cost included total hospital, inpatient rehabilitation, and revision cost for each cohort over five years. The primary outcome measure, incremental cost per QALY gained, was calculated by estimating mean incremental costs and QALYs of surgery compared to failed medical management of each diagnosis group after discounting costs and QALYs at 3%. Sensitivity analyses were conducted to determine factors affecting the value of each type of surgery. Results: The lifetime ICUR was $4,091/QALY for THA, $5,038/QALY for TKA, and $3,530/QALY for combined spine surgery groups (DF = $7,444/QALY and D = $2,261/QALY). Values are based on life expectancies of 20.4, 19.1 and 19.6 years for hip, knee and spine patients respectively. The sensitivity analyses (variations of outcome, cost, and revision rate) did not alter the ranking of the lifetime ICURs. Conclusion: Compared to failed medical management, surgery for hip, knee and spine osteoarthritis is cost-effective. Furthermore, the ICUR of surgery for focal spinal stenosis with or without degenerative spondylolisthesis (D+DF) was comparable to that of THA and TKA. 200: Drug Release and Bone Growth Studies of Antimicrobial Peptide-loaded Calcium Phosphate Coating on Titanium Implants Bas A Masri, BC; Mehdi Kazemzadeh-Narbat, BC; Shahryar Noordin, BC; Donald S Garbuz, BC; Clive P Duncan, BC; Robert EW Hancock, BC; Rizhi Wang, BC Purpose: Preventing infection is a major challenge in total joint arthroplasty. There are few reports on in-vivo bone growth on antimicrobial peptide-loaded orthopaedic implants. Antimicrobial peptides (AMP) are well recognized as promising novel agents against multi-drug resistant pathogens. This work investigated the in-vitro drug release, antimicrobial performance, and cytotoxicity, as well as the in-vivo bone ingrowth of an antimicrobial peptide (AMP) loaded into calcium phosphate (CaP) coated Titanium (Ti) implants, in a rabbit model. Method: Two potent AMP candidates (HHC36: KRWWKWWRR), and (Tet213: KRWWKWWRRC) were first investigated through an in-vitro cytotoxicity assay. MTT (3-(4,5dimetyl-2-tiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) absorbance values revealed that HHC36 showed much lower cytotoxicity (200 µg/mL) than Tet213 (50 µg/mL). The in-vivo rabbit study utilized 25 adult New Zealand white female rabbits, randomly distributed to three groups of implants, Ti (5 rabbits), CaP (10 rabbits), and CaP-AMP (10 rabbits). Each rabbit received two identical implants, one in each femur. Surgery was performed under sterile conditions and general anesthesia. Animal study protocol was approved by the Animal Care Committee at the University of British Columbia. Results: The CaP-AMP coatings were antimicrobial against Staphylococcus aureus and Pseudomonas aeruginosa strains in colony-forming units (CFU) assays. The AMP HHC36 loaded onto CaP had a burst release during early hours followed by a slow and steady release for seven days as measured using UV/Vis (Ultraviolet-Visible) spectroscopy. No cytotoxicity was observed on CaP-AMP samples against MG-63 osteoblast-like cells after five days. In a trabecular bone growth study using cylindrical implants, loading of AMP HHC36 did not impair bone growth onto the implants. Significant bone on-growth was observed on CaP-coated Ti with or without HHC36 loading, as compared with Ti alone. Conclusion: The AMP-CaP coating thus offers antimicrobial and osteoconductive properties to orthopaedic implants. This coating can significantly kill S. aureus and P. aeruginosa bacteria while being non-cytotoxic to MG-63 osteoblast like cells. The in-vivo bone on-growth on CaPAMP was observed to be extensive in comparison to controls. The calcium phosphate coating and the simplicity of AMP loading will be the advantages of this antimicrobial coating. 201: Factors that Impact the Choice to Undergo Surgery (FICUS): Enabling Improved Patient Decision Aids Raja Rampersaud, ON; Rajiv Gandhi, ON; Anthony Perruccio, ON; Arthritis Program UHN, ON Purpose: In orthopaedics, willingness to undergo surgery is often a preference-sensitive decision. The factors that influence patient willingness however, are poorly understood. Hence current orthopaedic patient decision aids may be inadequate. We sought to identify patient characteristics associated with unwillingness to undergo surgery if offered, and to evaluate whether the influence of some characteristics may be explained by perceptions of surgical risk and expectations of success. Method: Immediately prior to surgical consultation for degenerative spine, hip/ knee (H/K), shoulder/elbow (S/E), or foot/ankle (F/A) conditions, patients completed a survey that ascertained willingness (unwilling/unsure/willing) to have surgery (primary outcome of interest), captured demographic and socioeconomic characteristics, and assessed overall physical and mental well-being (SF-36) and patient expectations of surgical success (unsuccessful/unsure/successful) and perceptions of risk (risky/not risky/unsure). Sequential multinomial logistic regression models were evaluated. First, patient characteristics were examined as predictors of perception of risk and expectation of success. Then, all characteristics (including risk and success) were evaluated as predictors of willingness. Results: Two-thousand patients completed the survey with valid data from 1,954 patients: 51% were male and 454 (23%) were evaluated for a spine condition, 767 (39%) for H/K, 384 (20%) for S/E, and 349 (18%) for F/A. Overall, 20% of patients reported unwillingness or uncertainty about surgery and 50% reported being ‘unsure’ about the risk and success of surgery. Mean SF-36 subcomponent scores were similar for patients across specialities. From adjusted analyses, females (Odds Ratio (OR) = 1.3 and 1.6) and individuals consulting for spine (OR =3.7 and 3.0) and S/E (OR=1.4 and 1.9) (as compared to H/K) were significantly more likely to report uncertainty regarding risk and success. Individuals of South Asian ethnicity (OR=5.3) and those consulting for F/A (OR=1.6) also were significantly more likely to report uncertainty regarding success. Independent predictors of unwillingness to have surgery were expectations of unsuccessful surgery (OR=26.6), a perception of ‘risky’ surgery (OR=2.0), increasing age (OR=1.02), female (OR=1.6), ethnicity: Black, South Asian and Other (OR=4.2, 3.6, and 2.3, respectively (as compared to White)), and increasing levels of bodily pain (OR=1.02). Having had a previous surgery was associated with a greater likelihood of ‘willingness’ (OR=0.45). Adjusted for all variables, BMI, education, comorbidities, physical function and mental well-being were not predictive of willingness. Conclusion: The determinants of willingness to consider surgery are multifactorial. These study findings suggest that a number of factors should be considered when developing orthopaedic consultation patient decision-aids and direct surgeon-patient communication strategies. 202: Looking Beyond the Clinical Box: The Health Services Impact of Surgical Adverse Events Clifford Lin, ON; Raja Rampersaud, ON; Camalene Chrysostoum, ON Purpose: In the Canadian healthcare system, access to inpatient beds is an ongoing and escalating problem. For surgical services, cancellation of elective surgery directly impacts access to care and is an increasing source of frustration to all stakeholders. The primary purpose of this study was to assess the impact of perioperative adverse events (AEs) on available hospital bed days. Method: Preliminary analysis of data from a prospective observational study. Information regarding patient demographic, diagnosis, procedure, and length of stay is being captured by dedicated research personnel on all in-patient orthopaedic and spinal surgical procedures at our institution. Occurrences of AEs are documented and categorized daily using the OrthoSAVES system. Data from the first 6 months (n=908 patients) was analyzed. Results: In this period there were 227 AEs (intraoperative and postoperative) in 154 patients (17%). The most common AEs were urinary tract infection (n=33), durotomy (n=23), delirium (n=21) and urinary retention (n=17). The majority of adverse events (n=196, 86%) were grade I-II, those that did not require treatment or required minor treatment but were not likely to impact patient outcome. There were significantly less Grade III-IV AEs (n=21, 9.7%), those requiring treatment and are likely to impact patient outcome. Adjusting for age, sex, body mass index, American Society of Anesthesiologists (ASA) physical status, and procedure type, the mean length of stay (LOS) was 7.0 days (95% confidence interval (CI):5.9-8.1) for patients without AEs, 11.9 days (CI:10.4-13.4) for grade I-II AEs and 19.9 days (CI:17.2-22.1) for grade III-IV AEs. Compared to the mean LOS within matched procedure group for patients without AE, individual patients with grade I-II AEs led to approximately 654 additional days in hospital. Those with grade III-IV AEs resulted in approximately 373 additional days in hospital. Conclusion: AEs are responsible for a significant number of additional bed days. The majority of AEs were of low grade and preventable or modifiable. The development of evidence-based protocols targeting these “minor” AEs can lead to improved system efficiency. 203: Responding to the Global Injury Burden by Improving Access to Orthopaedic Medical Devices: A Qualitative Case Study of Orthopaedic Services in Uganda Maryse Bouchard, ON; Jillian Kohler, ON; James Orbinski, ON; Andrew Howard, ON Purpose: This study investigates the access of orthopaedic medical devices (OMDs) in Uganda. The global injury burden is severely underappreciated. Orthopaedic injuries account for 14% and 9% of the world’s morbidity and mortality, respectively. Ninety percent of injury deaths occur in low- and middle-income countries. Globally, injuries cause approximately as many deaths per year as HIV/AIDS, tuberculosis and malaria combined. By the year 2030, road traffic crashes, a major cause of orthopaedic injury, are predicted to be the third leading cause of long-term disability globally. Alleviating the burden of orthopaedic injuries will require timely access to appropriate orthopaedic care and medical devices, such as plaster, an external fixator or an implant. In many low-income countries however, orthopaedic services and OMDs are generally inadequate or unavailable, as the required expertise, infrastructure and funding are often lacking. Despite the negative health impact when OMDs are unavailable, this is an area that has not been a global health priority and demands immediate attention. Method: An exploratory qualitative case study consisting of 45 open-ended interviews was conducted in Uganda in 2010. The interviews explored stakeholders’ experiences in accessing OMDs in their health care setting. Participants included 16 orthopaedic surgeons, 13 health care professionals other than orthopaedic surgeons (orthopaedic officers, general surgeons, medical officers, and nurses), 8 industry representatives, 2 government officials, and 6 patients. Participants were recruited by purposive and snowball sampling. Thematic analysis was the method used for data analysis. Results: Analysis of the interview data revealed two broad categories: “Barriers to access of OMDs” and “Solutions for improving access to orthopaedic care”. Four major themes were elicited as barriers to OMDs: 1) Poor leadership and corruption in government; 2) inadequate human resources; 3) inefficient and insufficient healthcare infrastructure; and 4) high costs of OMDs and poverty. Potential solutions for improving access to orthopaedic care included policies for prioritization of orthopaedic services, training of more orthopaedic specialists and incentives for them to work rurally and in the public system, and innovative strategies funding for orthopaedic services. Conclusion: Problems of governance, limited human resources, inadequate health care infrastructure, and high costs of orthopaedic equipment, prevent access to needed OMDs in Uganda. Without these medical devices, the quality of orthopaedic care suffers and the burden of preventable injury is exacerbated. Mechanisms to increase access to OMDs and orthopaedic care globally could include improved transparency in governance, training of more orthopaedic specialists, policies for prioritization of trauma in health care, and additional funding for orthopaedic care, including OMDs. Further research into this global health challenge is needed. 205: Undiagnosed Diabetes Mellitus in Patients Undergoing Elective Total Joint Replacement Robert J Feibel, ON; Erin J Keely, ON; Janine C Malcolm, ON; Bob Reid, ON Purpose: Peri-operative hyperglycemia has been shown to increase the risk of prosthetic infection. Patients without the diagnosis of diabetes mellitus are at increased risk of developing deep infection when hyperglycemia occurs following surgery. Method: Between October 2010 and September 2011, 251 patients undergoing elective total hip or knee replacement were screened pre-operatively for diabetes mellitus by random blood glucose and hemoglobin A1C (HgbA1C). Patients with negative screening blood work were assigned to Group 1 – Diabetes Unlikely. Those with one or both screening tests positive were assigned to Group 2 – Possible Diabetes. In order to assess the adequacy of a random blood glucose and HgbA1C as screening tools for the detection of diabetes, 25% of the Group 1 (“diabetes unlikely”) patients were screened with a Glucose Tolerance Test (GTT) at 6 weeks post-operatively. Results: There were 230 patients (91.6%) in Group 1 (Diabetes Unlikely) with a mean age of 62.6 years and 17 with possible diabetes in Group 2 (6.8 %, four lost to follow-up, mean age 73.6 years). Ten patients in Group 2 were referred for post-operative follow-up testing with a GTT: two normal; four pre-diabetic; four positive for diabetes; and 7 GTT pending or lost to follow-up. Thirty-nine Group 1 patients were screened with a GTT: 28 normal; 11 pre-diabetic. Hence, 28 % of these ‘normal’ patients were identified as being pre-diabetic or diabetic. All study patients (Both Group 1 and 2) had a normal screening random blood glucose. Body Mass Index did not correlate with abnormal blood work or GTT. The only significant difference was a tendency for Group 2 “Possible Diabetes” patients to be older (p<0.001). The 30-day readmission rate was not statistically different between the groups. Conclusion: These findings suggest that up to one third of asymptomatic non-diabetic patients undergoing total joint replacement may be at risk of developing stress-induced post-operative hyperglycemia or have diabetes and, hence, are at increased risk of developing a prosthetic infection. 206: Arthroscopic Repair of Massive Rotator Cuff Tears Using a Novel Biceps Incorporation Technique Aaron Nauth, ON; Anne-Marie Bedard, BC; Brianne Bentzon, BC; Cheryl Davies, BC; William D Regan, BC Purpose: Numerous operative techniques have been described for the treatment of massive rotator cuff tears where anatomical repair is not possible. However, poor healing and poor functional outcomes after surgical intervention remain significant problems. We describe the arthroscopic repair of massive rotator cuff tears in a series of 22 patients, using a novel biceps incorporation technique. The purpose of the current study was to evaluate the functional and radiographic outcomes of arthroscopic repair of massive rotator cuff tears using a novel technique of biceps incorporation. Method: Between January 2007 and January 2010, twenty-two shoulders with massive rotator cuff tears, irreparable using standard arthroscopic techniques, underwent repair using a novel arthroscopic biceps incorporation technique and were included in the analysis. Our technique involves the liberal use of marginal convergence sutures incorporating the biceps, followed by anchoring of the converged tendon and biceps to the greater tuberosity using suture anchors. All patients underwent a standardized assessment at a minimum of one year post-operatively, including an ultrasound examination to assess for radiographic healing of their tear. The mean follow-up period was 23 months (range = 12-29). Results: All 22 patients reported satisfaction with the surgery and willingness to have the surgery performed again. The mean age-adjusted Constant and American Shoulder and Elbow Surgeons (ASES) scores post-operatively were 98.8 (range = 47 – 130) and 83.4 (range = 34 – 100), respectively. The mean Western Ontario Rotator Cuff index (WORC) post-operatively was 76.0% (range = 20.0% – 98.5%). The mean Physical and Mental components of the Short Form-12 (SF-12) questionnaire were 45.7 (range = 10.0 – 60.4) and 52.1 (range = 28.2 – 63.9), respectively. On the basis of Constant scores, 91% (20/22) of patients had an excellent/good result. Ultrasound examination showed that 36.4% (8/22) of patients had radiographic evidence of complete rotator cuff tears post-operatively and that 40.9% (9/22) had radiographic evidence of partial tears, while the remaining 22.7% (5/22) were judged to be radiographically intact. Statistical comparison of patients with radiographically intact/partially intact rotator cuff repairs to those with complete re-tears showed no significant differences. Conclusion: Despite a low rate of radiographic healing, massive rotator cuff tears repaired arthroscopically using our biceps incorporation technique showed high levels of patient satisfaction and excellent/good functional outcomes on the basis of general, joint-specific, and disease-specific outcome measures. The use of an arthroscopic technique of biceps incorporation for the repair of massive rotator tears may result in improved clinical outcomes, and a prospective, comparative evaluation of this technique with conventional methods of repair is warranted. 207: Comparison of Biomechanical Characteristics of Three Arthroscopic Knots; the Pretzel Knot, the SMC Knot and the Square Knot Zeeshan M Sardar, QC; Hasan Sawan, QC; Russel Ward, QC; Thomas Steffen, QC; Moreno Morelli, QC Purpose: Arthroscopic knot tying is an integral part of arthroscopic shoulder surgery and therefore surgeons performing arthroscopic shoulder surgeries should be proficient in such knot-tying techniques. The ideal knot would have satisfactory loop security, knot security, easy slidability, slack free configuration and a low profile on the tissues. We compare two commonly used knots, the SMC (Samsung Medial Centre)knot and the Square knot , with a relatively newer type of knot; the Pretzel Knot. The “Pretzel” knot is a type of a flip knot that is simple to learn and prepare and pretzel shape is easily visualised to confirm correct knot technique. Potential advantages of Pretzel knot include easy slidability because of only two half hitches and low profile. It is also easy to teach and learn. Method: The Pretzel knot was compared with two commonly used arthroscopic knots; the SMC knot and the Square Knot. Four different suture materials were used to also detect the effect of suture material on knot characteristics for the three knot configurations; (1) No. 2 HI FI (CONMED, Polyethylene) , (2) No. 2 Force Fiber (Stryker, Ultra High molecular Weight Polyethylene), (3) No.2 Ultrabraid (Smith&nephew) , (4) No. 2 FiberWire (Arthrex) , (5) No. 2 Johnson & Johnson. Five knots of each type were tied by the same senior surgeon with each of the different suture materials accounting for a total of 25 knots for each knot type Results: Our preliminary results show that the square knot is significantly stronger to the other two knots because of the higher load to failure and higher resistance. There were no statistically significant differences in the weight, failure to load and resistance between the Pretzel knot and the SMC knot. There was significant difference in the weight of the Pretzel knot when compared to the Square knot with the SMC knot being lighter. Conclusion: The vast number of suture materials and types of knot configurations available for Orthopaedics surgeons in the field of shoulder arthroscopy leaves the surgeon in a quest to find the optimal combination when performing arthroscopic shoulder surgeries. The ideal knot would have satisfactory loop security, knot security, easy slidability, slack free configuration and a low profile on the tissues. Our study shows that the Pretzel knot exhibits these features and is not inferior to the SMC knot. Considering it’s easy implementation, the Pretzel knot is good option for experienced and less experienced Orthopaedic Surgeons. 208: Comparison of Pain and Medication use in Patients undergoing Double-bundle versus Single-bundle Anterior Cruciate Ligament Reconstruction Mark Heard, AB; Simon MacDonald, AB; Laurie A Hiemstra, AB; Gregory L Buchko, AB; Sarah Kerslake, AB Purpose: The purpose of this study was to compare the pain and medication use of singlebundle (SB) versus double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) patients in the acute post-operative period. In addition, spinal versus general anesthesia approaches were analyzed for pain and medication use within both surgery types. Method: A standard logbook was used to record self-reported pain and medication use by patients who underwent SB or DB ACLR surgery. Pain was assessed using a 100mm visual analog scale, and was recorded at specific intervals from the day of surgery until day 14 post- operative. Medication use was recorded at these intervals over the same time period and divided into three categories: 1) Oral opioids 2) Oral NSAIDS and 3) Acetaminophen. Results: A total of 88 patients underwent SB and 41 patients underwent DB ACLR surgery. Over the 14-day post-operative period, there was no statistically significant difference in mean VAS pain scores between the SB and DB groups. However, pain differences between the two procedures showed a general trend of the DB ACLR being more painful over the first 4 days post-operative. There was also significantly more opioid and analgesia medications consumed by the DB patient group over the 14-day period (p < 0.05). On average, for both DB and SB procedures, patients who underwent spinal as opposed to general anesthesia experienced less pain over the 14-day period, with a significant difference in pain at 1-hour post-operative for both procedures (p < 0.001). For the DB ACLR procedure, opioid use was significantly higher in patients who underwent general compared with spinal anesthesia over the 14-day period (p < 0.001). Conclusion: These results demonstrate patients in the DB group self-medicated to acceptable levels of pain by consuming significantly more opioids than the SB patients; thereby indicating the DB procedure was more painful. Patients who underwent spinal compared with general anesthesia generally experienced less pain over the initial 14-day post-operative period. 209: Early Mobilization Following Mini-open Rotator Cuff Repair Matthew Souster, AB; Rob Balyk, AB; Charlene Luciak-Corea, AB; Fiona Styles-Tripp, AB; Martin Bouliane, AB; Jeff Bury, AB; Robert Glasgow Jr, AB; Lauren Beaupre, AB; David Sheps, AB Purpose: Mini-open rotator cuff repair (MORCR) is a common treatment for rotator cuff (RC) disease. Traditional shoulder rehabilitation supports immobilization for the initial 6 postoperative weeks to promote tendon healing. However, delayed range of motion (ROM) may slow the return of shoulder ROM, increase the risk of stiffness, and disrupt patients’ quality of life. The effect of early motion and the subsequent effect on clinical outcomes are unknown in humans. We evaluated the clinical outcomes following MORCR treated with early ROM compared to those who followed the standard immobilization protocol. Method: 187 patients with radiographically-confirmed full-thickness RC tear underwent a MORCR performed by fellowship-trained upper extremity surgeons (n=6). Subjects were randomized to one of two treatment groups following a preoperative assessment of shoulder pain, ROM, abduction strength and health related quality of life (HRQL) using a diseasespecific measure. During the first 6 postoperative weeks, subjects randomized to early mobilization (n=97) self-weaned from the shoulder immobilizer and performed painfree active ROM for activities of daily living (ADLs) while the standard immobilization group (n=90) wore a sling. Both groups completed identical rehabilitation protocols after 6 weeks. Shoulder ROM and pain were assessed at 6-weeks and three-months postoperatively. At 6-months, subjects had their abduction strength and HRQL assessed in addition to shoulder pain and ROM. Results: The two groups were similar preoperatively in power, ROM, HRQL, and pain (p>0.10). Six-week ROM comparisons demonstrated that the early mobilization group had increased abduction (p=0.03), flexion (p=0.01) and scaption (p=0.003), but these differences disappeared by 3-months (p>0.32). There was no difference in power (p=0.85) or HRQL (p=0.72) between groups at 6-months. Conclusion: Patients who performed painfree active ROM for ADLs had no significant difference in power, ROM, HRQL, or pain at 6 months compared to those who were immobilized for 6 weeks following MORCR. Early ROM did not show any significant benefits for minimizing long-term stiffness and pain, but clinically there was no compromise of their postoperative shoulder power or HRQL. Consideration should be given to allow patients to start actively using their shoulder within the first 6 weeks following a MORCR. 210: Initial Validity and Reliability of the Banff Patellar Instability Instrument (BPII) Laurie A Hiemstra, AB; Mark R Lafave, AB; Sarah Kerslake, AB; S Mark A Heard, AB; Gregory L Buchko, AB; Nicholas GH Mohtadi, AB Purpose: Patellar instability is a common problem yet there are currently no published, patient-reported, outcome measures that are disease-specific for this population. The purpose of this study was to determine if the Banff Patellar Instability Instrument (BPII) is a valid and reliable outcome for measuring quality of life in subjects with recurrent patellar instability. Method: A modified Ebel procedure was employed to validate the content of the BPII. This procedure is a three stage process consisting of: 1) simple validation by a local group of experts; 2) formal adoption from an international group of experts; 3) face to face discussion of international experts followed by modification of the instrument if 80% agreement did not occur in the second stage. As a measure of internal consistency, Cronbach’s Alpha was utilized to assess how reliably the 32 items of the BPII measured a similar construct (patellar instability). One hundred and twenty patients with a confirmed diagnosis of patella instability from one of the three orthopaedic surgeons completed the BPII at the initial orthopaedic consult (presurgery), 6 month follow-up appointment (post-surgery) and 12 month follow-up appointment (post-surgery). Surgical procedures included medial patellofemoral ligament (MPFL) reconstruction, MPFL imbrication, tibial tubercle transfer, knee arthroscopy or any combination thereof. Data from each item of the BPII, as well as the cumulative score, was used in the Cronbach’s Alpha Reliability Coefficient analysis. Results: Content validity was clearly established as each item in the BPII achieved a minimum of 83.3% (range 83.3-100%) agreement for relevance among the expert panellists at the second stage of the modified Ebel procedure. The average agreement was 96.9% and 24/32 questions achieved 100% agreement. Reliability of the BPII was established at the initial orthopaedic consult (reliability co-efficient = 0.91), 6 months post-operatively (reliability coefficient = 0.96) and 12 months post-operatively (reliability co-efficient =0.96). Conclusion: This study has established the BPII is valid and reliable in patients with recurrent patellar instability as well as patients who have had a patellar stabilization procedure. 211: Mechanical Stimulation Enhances Integration in an in vitro Model of Cartilage Repair John Theodoropoulos, ON; Am DeCross, ON; Sam Park, ON; Massimo Petrera, ON; Rita Kandel, ON Purpose: The ability of articular cartilage to self-repair is limited due to the nature of the tissue. Tissue-engineered cartilage is a promising alternative for the treatment of cartilage injuries. It is known that cartilage not stimulated by movement deteriorates with time. Although research has focused on using mechanical stimulation to improve the mechanical properties of tissueengineered cartilage; there is little known about the effect of mechanical stimulation on the integration of tissue-engineered cartilage with host cartilage. We have established an in vitro model of repair cartilage integration using tissue-engineered cartilaginous tissue implanted into host bovine articular cartilage. Based on the role of mechanical loading on tissue-engineered cartilage properties, we hypothesized that mechanical stimulation would enhance the integration of the repair implant with the adjacent host cartilage. Method: Constructs composed of tissue-engineered cartilage implanted into host cartilage were maintained in spinner bioreactors in the presence or absence of rotational forces (0 or 90 RPM). After 2 and 4 weeks of incubation, the constructs were evaluated for changes in gene expression, matrix accumulation and extent of fusion at the integration site. Results: Both time and mechanical stimulation in spinner bioreactors lead to improved integration between host and implant tissue as determined histologically by semiquantifying percent integration as well as biomechanically by a push-out test. Integration did not occur if the implant was not viable. Collagen content significantly increased in the integration zone between host and implant at 2 weeks. The gene profile of cells in the integration zone differs from host cartilage demonstrating an increase in the expression of membrane type 1 matrix metalloproteinase (MT1-MMP), aggrecan and type II collagen. Conclusion: These results suggest that the integration of in vitro tissue-engineered implants with host tissue improves with mechanical stimulation and that the implant is responsible for integration. 212: PASTA Bridge - A New Technique in PASTA Repairs: A Biomechanical & Clinical Evaluation Alan Hirahara, US Purpose: The purpose of this study was to evaluate the biomechanical and clinical effectiveness of a new PASTA repair technique – PASTA Bridge. Method: For the PASTA Bridge repair, a 17 gauge spinal needle, followed by a Nitinol wire, dilation instrument, drill spear, a 1.8 mm drill, and then a 2.4 mm BioComposite SutureTak (Arthrex, Naples, FL) was done twice to place the anterior and posterior anchors. Each anchor position was approximately 5 mm from the centerline of the footprint. A strand of suture from each anchor was tied in a similar manner as the “double pulley” method described by Lo. The opposing two limbs were tensioned to pull the knot taunt over the repair site, and fixated laterally with a 4.75 mm BioComposite SwiveLock (Arthrex, Naples, FL) placed approximately 1 cm lateral of the greater tuberosity. For the biomechanical evaluation, a 50% articular-sided partial tear of the supraspinatus tendon was created on six matched pairs of fresh frozen cadaver shoulders. From each matched pair, one humerus received a PASTA repair using one 4.5 mm titanium Corkscrew FT with a horizontal mattress suture while the contralateral repair received a PASTA Bridge configuration.Each sample was pre-loaded to 10N followed by cyclic loading between 10 and 100N, at 1 Hz, for 100 cycles. Post cycling, the samples were loaded to failure at a rate of 33 mm/sec. Load and position data were recorded at 500 Hz, and the mode of failure was noted for each sample. Displacement and strain was calculated using video tracking and individual marks on the supraspinatus.For the clinical evaluation, thirty-one patients had their PASTA lesions repaired with the PASTA Bridge while twenty-six patients were repaired using a standard trans-tendon technique using a 3.7 mm BioSutureTak (Arthrex, Naples, FL) with a horizontal mattress repair.Non-compliant patients and those suffering postop trauma were excluded. Patients were evaluated clinically with VAS pain scores, ASES scores, days to discharge, and return to work. Repeat ultrasound or MRA was performed for people having persistent pain to evaluate healing. Results: For the biomechanical evaluation, there were no significant differences between the two repairs in ultimate load (p = 0.577), strain at the repair site (p = 0.355), or strain at the margin (p = 0.801). The modes of failure were the tendon tearing mid-substance, the humeral head breaking, the muscle body tearing from the tendon, or the tendon tearing at the repair site. All four of these modes of failure occurred in at least one sample from both repair groups. Visual inspection of the samples post-testing revealed no damage to the anchors or suture damage.For the clinical evaluation, four out of twenty-six (15.4%) control patients failed to heal, requiring revision repair while only one out of thirty-one (3.2%) study patients failed to heal (p<0.0001). Pain scores decreased and ASES scores increased in both groups from pre-op to six months (Study: 7.4 to 3.1 & 39.9 to 68.2 / Control: 6.9 to 3.4 & 42.7 to 68.6, p=NS). Days to discharge & return to work were 137.9 / 119.8 and 198.7 / 106.3 for Study / Control groups, respectively (p= NS). Conclusion: The biomechanical study showed that our PASTA Bridge construct creates a very strong construct in repairing articular-sided partial-thickness tears of the supraspinatous. There was no significant difference between this construct and a standard single suture anchor for ultimate load or strain at the margins or repair site. The clinical results of this study show that the PASTA Bridge technique was more effective than the standard trans-tendon technique for healing but had similar decrease in pain and increase in function. This technique, in contrast, is a percutaneous, simple procedure requiring no arthroscopic knot tying and carries only a minimal chance of damage to the residual tissue. Further study to enhance the power of this study is required. 213: Percutaneous Inside-out-outside-in Medial Meniscal Repair During Anterior Cruciate Ligament Reconstruction: A Prospective Study Nicholas GH Mohtadi, AB; Hamish Love, NZ Purpose: This study describes a simplified hybrid suture repair technique for medial meniscal tears and assesses the effect of medial meniscal injury and treatment on the outcome of anterior cruciate ligament (ACL) reconstruction. Method: A prospective comparative study (levels of evidence, level II). Two-hundred and ninety-two patients treated with ACL reconstruction and concurrent treatment of meniscal injuries. Patients were divided into treatment groups based on the management of the medial meniscus into no treatment, repair or meniscectomy. Pre-operative, 6, 12 and 24-month clinical assessment and outcome scores with ACL-Quality of Life and International Knee Documentation Committee (IKDC) scores were performed. Results: Meniscal tears were present in 66.7% of medial and 77% of lateral menisci in ACLdeficient knees. Over 50% of medial meniscal tears were amenable to repair. The groups were comparable in terms of demographics, lateral meniscal pathology and ACL reconstruction technique used. Meniscal repair added 9.6 minutes to the operative time. No operative complications of meniscal repair were noted. At an average follow up of 21.3 months, no significant difference in outcome scores was noted between treatment groups. The medial meniscal revision rate was 7.1% with ongoing meniscal symptoms in a further 6.7%. Conclusion: Medial meniscal repair using a simplified, hybrid suture technique is a safe and efficient method for repairing medial meniscal tears. Success rates are equivalent to inside-out suture techniques. Outcomes of ACL reconstruction, at least out to 2 years, are not detrimentally affected by the presence of medial meniscal pathology, if treated appropriately. 214: Platelet-rich Plasma vs. Cortisone Injections for the Non-surgical Treatment of Shoulder Pain Alan Hirahara, US Purpose: To evaluate pain and functional improvement in shoulder pain with PRP injections versus cortisone Method: This is a case-control, non-randomized study using 148 study patients who received a PRP injection and 246 control patients who received a cortisone injection for shoulder pain. Inclusion criteria were any patients having shoulder pain during the collection period already having tried NSAID's and physical therapy. Patients were evaluated clinically with pain scores and ASES scores for six months. Exclusion criteria were non-compliance with the physical therapy regimen or post-injection trauma. Results: Overall pain and ASES scores improved for both study and control groups (Study: 6.3 to 3.2 & 45.1 to 66.5 and Control: 6.8 to 3.7 & 40.1 to 63.3, p=NS) with statistically significant improvement starting at days 2 and 1 (pain) and days 4 and 1 (ASES), respectively; however, there was no statistical significance between the study and control groups at 6 months, but PRP showed significantly better pain/function during months 3-5. Patients with tendonopathy and PASTA lesions all showed significant improvement in all measures but were significantly better for the PRP study group by 5 months & 1 month, respectively (p=0.027 & p=0.006). Patients with DJD did improve with a tendency for recurrence after a few months in both groups but the cortisone group showed continued improvement significantly at 6 months (p=0.026). Adhesive capsulitis and full thickness rotator cuff tears improved equally with either cortisone or PRP injections, but RC tears only mildly. Conclusion: This study shows that PRP injections are equivalent to cortisone injections to help decrease pain and improve functionality in shoulder pain. However, each individual diagnosis carries a different outcome with the different injections. Tendonopathy and PASTA lesions had significantly better outcomes with PRP than cortisone injections. While pain in the cortisone group usually returns, it usually did not with PRP. Cortisone does have a faster onset than PRP, and cortisone did diminish pain longer in DJD patients over PRP. Patients with adhesive capsulitis and full thickness RC tears had relief from PRP and cortisone equally. Further study is required to evaluate each diagnosis individually to better elucidate the best use of PRP 215: Validation of a Classification for Patients with Patellar Instability Laurie A Hiemstra, AB; Mark R Lafave, AB; Sarah Kerslake, AB; S Mark A Heard, AB; Gregory L Buchko, AB Purpose: Patients with patellar instability present with a wide range of etiologies and symptoms as well as varied anatomic and neuromuscular characteristics. As with shoulder instability, these patient types present as a continuum. For patella instability, the authors propose that two main subsets of patients present. This study introduces a novel classification system, WARPS (Weak, Atraumatic, anatomy Risky, Pain, and Subluxation) and STAID (Strong, Traumatic, Anatomy normal, Instability and Dislocation) The purpose of this study was to demonstrate inter-observer reliability of the classification continuum of WARPS and STAID for patella instability. Method: Twenty-five consecutive patients with a confirmed diagnosis of patellar instability were included. Each patient underwent a thorough history and physical examination concurrently with 3 assessors (orthopaedic surgeon, physiotherapist and athletic therapist). Each characteristic of the WARPS-STAID classification continuum was graded independently by each examiner on a 10 cm VAS. Each assessor also assigned a cumulative WARPS-STAID score to each patient. Intraclass Correlation Coefficient (ICC 3,3) was calculated for each pair of characteristics on the continuum and for the cumulative scores. Results: Intraclass Correlation Coefficient (3,3) of the WARPS-STAID classification continuum were W-S = 0.92; A-T = 0.95; R-A = 0.81; P-I = 0.84; and S-D = 0.91. The ICC (3,3) of the composite score was 0.84. Conclusion: These results demonstrate strong reliability of the classification system, WARPSSTAID for patients with patella instability. The classification system reliably differentiates between two distinct subsets of patella instability patients. 216: Cefazolin use in Patients with a History of Non-IgE Mediated Penicillin Allergy Nazari Dvirnik, ON; Sean Haslam, ON; David Yen, ON; Dale Engen, ON Purpose: To demonstrate the safe use of Cefazolin in patients with non-IgE mediated allergy to penicillin. To document the reported adverse reactions to penicillin and the number of cases the reactions are unknown despite a stated allergy to penicillin. To determine if a unified practice of using Cefazolin in all patients with non-IgE mediated penicillin allergy could be followed in a Health Centre. Method: The participants of this prospective quality control study were all the patients with a reported penicillin allergy who were of ages 18 and over, who were scheduled for surgeries that required prophylactic antibiotics at the Hotel Dieu and Kingston General Hospital between May 20, 2011 and August 9, 2011. Previous reactions were recorded from patient interviews and patients with non-IgE mediated penicillin allergies were given Cefazolin in a safe clinical setting and any allergic reactions were to be treated and documented. Results: Out of a total of 3551 patients, 430 stated an allergy to penicillin (12.1% allergy prevalence). Out of these, 2276 cases had the study inclusion criteria (age >18y, preferred cefazolin prophylaxis), in which 192 patients stated an allergy to penicillin. In our penicillin allergic study population, 70 patients (36.1%) reported IgE-mediated reactions, 101 patients (52.6%) reported non-IgE-mediated reactions and 21 patients (10.9%) had unknown reactions. Seventy-five patients (61.5%) with non-IgE-mediated allergies or unknown reactions received prophylactic Cefazolin. None of the study patients had immediate reactions to Cefazolin. Conclusion: A significant number of patients having elective surgery requiring prophylactic antibiotics state that they have an allergy to penicillin. A large proportion of the reactions in this patient group are non-IgE-mediated or unknown. Cefazolin can be safely used in these patients thereby reducing the use of alternative antibiotics like Vancomycin and Clindamycin with their associated risks. Despite an antibiotic use protocol pre-circulated by the physician manager, a unified practice of using Cefazolin was not followed. 217: Does A Dedicated Perioperative Cardiovascular Service Improve Patient-Important Outcomes? Justin de Beer, ON; Tammy Cosman, ON; Bill Evans, ON; Kim Alvarado, ON; Vikas Tandon, ON; Patrick Magloire, ON; Omid Salehian, ON; Tej Sheth, ON; Hisham Dokainish, ON; Sebastian Ribas, ON; George Stallwood, ON; Chuck Tomlinson, ON; Deborah Hastings, ON; Greg Curnew, ON; Mitch Winemaker, ON; Diane Heels - Ansdell, ON; PJ Devereaux, ON Purpose: Over 5 million adults suffer a major vascular complication within 30 days after noncardiac surgery annually. In an attempt to improve these outcomes at the Juravinski Hospital and Cancer Centre (JHCC), we initiated a Perioperative Cardiovascular Service (PCS) run by a nurse practitioner and the cardiology attending physician. The PCS was initiated on January 1, 2010. The PCS systematically screened all orthopedic surgery patients prior to surgery, performed a preoperative consult on all at-risk patients, determined the post operative care setting and monitoring requirements, and co-managed orthopedic surgery patients at-risk of a perioperative major vascular complication. The objective of this study was to determine whether the PCS improved the incidence of major vascular complications after orthopedic surgery. Method: We undertook a before-after study to evaluate the impact of the PCS. Patients aged >45 years who required at least an overnight hospital admission after undergoing orthopedic surgery were eligible. Patients who had surgery during the day or night, weekday or weekend, and who underwent an elective or urgent/emergent surgery were included. From October 22, 2007 to August 28, 2008 we recruited a representative sample of eligible orthopedic surgery patients at the JHCC to the Pre-PCS group. From March 1, 2010 until August 8, 2011 we recruited a representative sample of eligible orthopedic surgery patients at the JHCC to the Post-PCS group. All patients had a Troponin T measurement 6-12 hours after surgery and on days 1, 2, and 3 after surgery. Independent research personnel collected all outcome data. We assessed major vascular outcomes in the Pre-PCS and Post-PCS groups, and we undertook multivariable logistic regression analyses to determine if the PCS independently impacted major perioperative vascular complications. Results: We recruited 863 patients into the Pre-PCS group and 527 patients into the PostPCS group. In the Pre-PCS group the mean age was 69.1 years (SD 11.0), 58.7% of the patients were female, and 53.4% of the patients underwent knee arthroplasty. In the Post-PCS group the mean age was 67.8 years (SD 11.8), 57.1% of the patients were female, and 49.7% of the patients underwent knee arthroplasty. Fewer patients in the Post-PCS suffered a myocardial infarction (MI) (2.5% versus 5.0%, P=0.049) and congestive heart failure (CHF) (0.9% versus 3.2%; P=0.006). Our multivariable risk adjusted analysis demonstrated patients in the Post-PCS group had a lower risk of the composite outcome of MI or CHF (OR, 0.51, 95% CI, 0.27-0.96, P=0.036). Conclusion: These data suggest that a PCS may prevent MI and CHF after orthopedic surgery. 218: Does a Surgery on Known Infected Arthroplasty Cases Impact the Infection Rate of Clean Arthroplasty Cases in the Same Operating Room? Mansour Abolghasemian, ON; Amir Sternheim, ON; Alireza Shakib, ON; Oleg Safir, ON; Allan E Gross, ON; David Backstein, ON Purpose: Infection is a serious and highly morbid potential complication of joint arthroplasty. Every attempt is employed by the surgical team to decrease the load of bacteria in the operating room and in some places it is standard practice to close a room after a surgery on a known infected case until a thorough cleaning of the area is performed, usually over night. There is no evidence however, on necessity of this protocol. The present study was designed to investigate if there is any increased risk of infection when a non-infected joint replacement procedure is performed after an infected operation, in the same room, using standard O.R. cleaning protocols. Method: A retrospective review of all primary or revision total joint arthroplasties performed over a 4-year period (2007-2010) at our institution was conducted. Patients who underwent hip or knee arthroplasty immediately following a case of known infection in the same operating room were analysed (for the first six months after surgery, when infections may be attributed to contamination at the time of surgery) to determine the incidence of infection. This group of patients were matched regarding gender, age and surgery type to a large control group of patients operated on in the same period of time but were not performed in an OR which had just been used for an infected case. Culture data was collected for all infection occurrences. The rates of superficial and deep infections in the case and control groups were compared statistically. Results: A total of 58 hip or knee arthroplasty cases, including 10 revisions and 48 primaries, were eligible for the study group. They were all operated as the second case of the day immediately following a case of first stage revision for treatment of an infected joint. There was only one case of deep infection in the study group (1.7%) which occured in a primary total knee arthroplasty caused by Strep. viridians. The organism of the preceding infected case was Staph. aureus. One case of superficial infection (1.7%) was also identified. Two cases (3.4%) showed prolonged wound discharge after surgery. The control group included 354 joint replacements. There was one deep (0.28%) and 12 superficial (cellulitis or stitch abscess) infections (3.4%) and four prolonged wound drainage (1.1%) among them. Statistical analysis did not show any significant differences between the groups regarding deep (P value, 0.121) or superficial (P value, 0.21) infections or prolonged discharge rate (P values, 0.17). Conclusion: While the predisposing factors for deep and superficial infections are multiple, the role of a preceding infected case as a risk factor for infection of the following case does not appear to be well founded. There was only one deep infection in each group. This does not represent a statistically higher rate than the control group. Importantly, the single infection in the study group was not caused by the same organism as the preceding infected case, thus raising doubt about any relationship between the two. Superficial infections were not more prevalent in the case group. Of note, the sterility protocol in our operating room is a routine one which does not use laminar flow, body exhaustion systems or ultraviolet radiation. In summary, this study failed to show any increased risk of infection in primary or revision arthroplasties performed following an infected case. The authors see no indication for OR cleaning protocols beyond standard accepted methods, for joint replacements after infected cases. 219: Effectiveness Of A Medically Supervised Weight Loss Program For Morbidly Obese Women With Severe Knee Osteoarthritis: Two Year Follow-Up Stephen M Mann, ON; Mark M Harrison, ON; Alice B Aiken, ON; Brenda Brouwer, ON; Kamary Coriolano-Da Silva, ON Purpose: To determine the extent to which benefits, including improved pain, psychological status and functional abilities, attained from a medically monitored rapid weight loss program for morbidly obese women with knee osteoarthritis, persisted at two-year follow up. Method: Thirty-four women (age 45 to 66) with morbid obesity and severe osteoarthritis of the knee that presented to an orthopedic surgeon for total knee arthroplasty were offered enrollment into a medically supervised weight loss program prior to consideration of a total knee replacement. Twenty-six subjects chose to participate in the weight loss program. They were enrolled in the Dr. Bernstein diet program, (a low-calorie, low-fat diet) at no cost to them. We initially collected the following questionnaires at enrollment and every six weeks while they remained in the weight loss program: WOMAC, SF36, Self-Efficacy, Health Locus of control, Dieting Beliefs Scale, Body Image State Scale, and the Beck Depression Inventory as well as Functional tests, namely the Timed Up and Go (TUG) and 6 Minute Walk Test (6MWT).Previously presented data indicated that weight loss led to significant improvements in pain and functional ability, and alleviated or delayed the need for total knee arthroplasty in the majority of morbidly obese middle-aged women.At a minimum of two years following initial enrollment, participants were contacted and asked to undergo repeat administration of questionnaires and functional tests.Our hypothesis was that the benefits initially obtained from weight loss would not be maintained over two years. Results: Fifteen of the initial 34 subjects were available for follow up. There were no statistically significant differences in BMI, TUG or 6MWT, nor in scores on the WOMAC, SF36, Self-Efficacy, Health Locus of control, Dieting Beliefs Scale, Body Image State Scale, or the Beck Depression Inventory between initial evaluation and two-year follow up. The mean change in BMI between initial and follow-up was -2.2, and all but two patients weighed more than their lowest recorded weight during the study period. No patient was satisfied with her current weight at follow up.Three patients who presented for follow up had undergone an operative intervention for knee osteoarthritis, and another six patients were identified as having had surgery by radiographic review. Conclusion: While a low-fat, low-calorie medically monitored weight loss program is initially effective in achieving significant weight loss in morbidly obese women with severe knee osteoarthritis with resultant improvements in pain and functional ability, these benefits are not sustained at two-year follow up. Further analysis of cognitive and psychological factors may prove valuable in identifying a subgroup which will improve with conservative management 220: Family History of Total Joint Arthroplasty and Joint Space Width Narrowing on Plane Radiographs: Data from the Osteoarthritis Initiative (A Prospective Multicenter Study) Kenneth D Illingworth, US; Donald N Sullivan, US; Jacob D Sams, US; Steven L Scaife, US; John Horberg, US; Khaled J Saleh, US Purpose: Previous studies have shown a positive correlation between genetic factors and the predisposition for end stage osteoarthritis suggesting family history plays a role. Currently, plane radiography imaging provides the most consistent, quantifiable measure of joint disease and subsequent progression. The purpose of this study was to quantify joint space width narrowing on plane radiographs in patients with a positive family history of total joint arthroplasty and compare with patients with no family history. Method: Data used in the preparation of this article were obtained from the Osteoarthritis Initiative (OAI) public use data set (kXR_QJSW_Duryea16). Of the 1,805 patients (3,257 knees) patients with joint space width quantified, 218 knees in 137 patients had a positive family history of total joint arthroplasty and 503 knees in 335patients had no family history of total joint arthroplasty. Any patient with a previous history of knee surgery was excluded. Patients were separated into 3 age groups; 45-54, 55-64 and 65-74. All patients had standing flexion weight bearing posterior to anterior plane radiographs at baseline, 12, 24, 36 and 48 months. Mean medial and lateral joint space width was calculated using specific data points for each compartment; 7 measurements for the medial compartment and 9 measurements for the lateral compartment. Mean joint space width in the medial and lateral compartment was analyzed at each time point. Patient demographics obtained included BMI, abdominal circumference, gender, race, income and smoking in packs per year. Pearson correlation coefficients were used to compare joint space narrowing to age in both groups. Independent Ttests with a significance of p < 0.05 were used for comparison between all groups. Results: No significant difference was found between the two groups in regards to patient demographics. There was a statistically significant correlation between age in the non family history group (r = 0.26, p < 0.05) and the family history group (r = 0.30, p < 0.05). There was a statistically significant difference between medial and lateral joint space width in patients with a positive family history of total joint arthroplasty when compared to no family history at all time points in patients 65-74 years of age (p < 0.05). The average difference in joint space width between positive family history and no family history in this age group was 0.61 mm. Rate of joint space loss per year was also significantly higher in the family history group than the no family history group in both the medial (0.17 mm, 0.12 mm) and lateral (0.14 mm, 0.11 mm) tibiofemoral compartments (p < 0.05). Conclusion: An increasing age is associated with decreasing tibiofemoral joint space width. Patients between the ages of 65 – 74 with a positive family history of total joint arthroplasty have a significant decrease in joint space width on plane radiographs as well as an increased rate of joint space loss. 221: Patients’ Views On Surgeons’ Financial Conflicts Of Interest Mark W Camp, ON; David A Mattingly, MA; Allan E Gross, ON; Markku T Nousiainen, ON; Benjamin A Alman, ON; Martin F McKneally, ON Purpose: Revelations of kickbacks from surgical device manufacturers to orthopaedic surgeons raise the question whether surgeons can continue to collaborate with industry and maintain public trust. We explored post-operative arthroplasty patients’ views on financial relationships between orthopaedic surgeons and surgical device manufacturers, their views on disclosure as a method to manage these relationships and their opinions on oversight. We present our findings here to add needed surgical patient perspectives to the discussion of how physicians and surgeons can work productively with industry and still maintain public trust. Method: We surveyed 251 post-operative U.S. patients (an 88% response rate) and 252 postoperative Canadian patients (a 92% response rate) in follow-up hip and knee arthroplasty clinics. We developed our survey questionnaire by conducting preliminary qualitative interviews with post-operative arthroplasty patients at an academic hospital in Toronto. Their views on conflicts of interest were analyzed and these patient-derived concepts were used to draft our survey questions. We added relevant themes and questions found useful in previous surveys. We tested a questionnaire derived from these sources on non-surgical volunteers and post-operative arthroplasty patients, using cognitive interviews to ensure that questions would be understood. The final questionnaire contained items in six domains: trust, awareness and concern about financial relationships between surgeons and device manufacturers, opinions regarding oversight, attitudes towards disclosure of financial relationships, socio-demographic data, and surgical characteristics. Results: Few patients are worried about possible financial relationships between their surgeon and industry (6% of U.S. patients and 6% of Canadian patients surveyed). Most patients thought that it is appropriate for surgeons to receive payments from manufacturers for activities that can benefit patients, such as royalties for inventions (69% and 66%) and consultancy (48% and 53%). Most patients felt that it is not appropriate for their surgeon to receive gifts from industry (63% and 59%). A majority felt that their surgeon would hold patients’ interests paramount regardless of any financial relationship with a manufacturer (76% and 74%). A majority of patients wanted their surgeon’s professional organization to ensure that financial relationships are appropriate (83% and 83%); a minority endorsed government oversight of these relationships (26% and 35%). Conclusion: Few patients were worried about possible financial relationships between their surgeon and industry. Patients clearly distinguish financial relationships that benefit current or future patients from those that benefit the surgeon or device manufacturer. They view disclosure, without professional oversight as an insufficient method of managing financial relationships between surgeons and manufacturers. 222: Prospective Observational Study of Thromboembolic and Bleeding Events following Elective Hip and Knee Arthroplasty using Oral Factor Xa Inhibitor (rivaroxaban) for Thromboprophylaxis John J Murnaghan, ON; Jeffrey Gollish, ON; Deborah Anne Murnaghan, ON; Helen Razmjou, ON; Vikas Bansal, ON; Andrea Donovan, ON Purpose: The aim of this study was to prospectively document the incidence of thromboembolic and bleeding events in patients who received rivaroxaban as the primary prophylaxis. Method: Prospective, observational study of patients given oral Factor Xa inhibitor (rivaroxaban) following primary and revision Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA). All patients were approached to participate and consented. Patients treated with Rivaroxaban 10 mg po daily starting Post-Operative Day (POD) #1 for 15 days. Participants followed-up at 6 weeks and 3 months. Doppler ultrasound or venograms used to diagnose proximal DVT. Spiral CT, CT Angio or V/Q scan were used to diagnose PE. Bleeding complications were documented as ‘on prophylaxis’ starting 2 hours after first dose of anticoagulant therapy until 24 hours after the 15th dose. Research ethics approval was obtained. Results: From June 2010 to April 2011, 1686 patients underwent total joint arthroplasty: 1554 (92%) agreed to participate in the study. Of these,1527 patients were followed up at 3 months (98%). Twenty-seven patients were lost to follow-up. Complete data on 1527 patients is reported: 621 men, 906 women with mean age 66 years. TKA 929 (primary 823, revision 63, bilat 43). THA 637 (primary 574, revision 63). Patients received rivaroxaban: 1434. DVT: Five DVT reported by 3 months: 2 primary TKA and 3 Primary THAs. Total DVT= 5/1434= 0.3%. PE: There were 12 confirmed PE by 3 months: 7 TKA, 4 THA and 1 Revision THA. Total PE 12/1464=0.8%. Bleeding: Two major and 6 non-major surgical-site bleeds occurred. One major and 3 non-major non-surgical site bleeds occurred in patients who received rivaroxaban. Transfusion: Seventy-three (5%) received blood transfusions with no difference between patients who received rivaroxaban and those who did not (Fisher’s exact test: 0.17, p=0.17).There were two perioperative deaths which were not related to surgery, DVT, pulmonary embolism or bleeding. Conclusion: The incidence of thromboembolic events within a period of 3 months was 5/1434 (0.3%) for DVT and12/1434(0.8%) for PE. The incidence of major bleeding was 3/1434 (0.2%). There were no deaths related to DVT, PE or bleeding.These preliminary findings are similar to thromboembolic and bleeding event rates in the research trials ( symptomatic VTE 0.2-0.7% and major bleeding.0.1-0.7%).Our DVT and PE event rates may be higher than those reported in the RECORD trials because we treated all patients after all procedures for 15 days and followed them for 90 days. A number of events occurred after 6 wks follow-up: 4 DVT’s and 4 PE’s. Five out of 7 in-hospital PE’s occurred in TKA. Preliminary results are surprising for the number of pulmonary emboli which occurred while patients were still in hospital and for the number of DVT's which occurred between 6 weeks and 3 months. Further work is required to see if these trends are maintained. This study is ongoing. 223: Total Joint Replacement Readmission Rates and Reasons for Readmission Victoria R Avram, ON; Justin de Beer, ON; Will Ngai, ON; Danielle Petruccelli, ON; Mitch Winemaker, ON Purpose: A retrospective review of primary total joint replacement (TJR) patients was conducted to determine readmission rate and reasons for readmission within the first 28 days of discharge. Based on current institutional pressures to reduce acute hospital length of stay, it was hypothesized that “failure to cope” would be a significant factor for hospital readmission within 28 days of discharge. Method: Primary total knee (TKA) and total hip arthroplasty (THA) patients readmitted to hospital within 28 days of discharge were abstracted from a prospectively tabulated arthroplasty database of 4445 patients who underwent primary TKA or THA at one academic hospital between 2004 and 2008. Patient demographics, preoperative comorbidity profile, and reason for readmission were abstracted. Data were analyzed using descriptive statistics. Comparison of demographics and comorbidity profile between readmit patients and nonreadmitted patients over the same study period were analysed using independent samples ttest and chi-square test. Results: A total of 95 readmitted patients were identified, including 40 primary THA and 55 primary TKA patients, giving a readmit rate of 2.1% within 28 days of discharge. Mean number of days between discharge date and readmission date was 9.24 (±7.2). A total of 5/95 (5.3%) were readmitted for “failure to cope”. The most common reasons for readmission were found to be septic complication (22/95, 23.2%), cardiovascular event (16/95, 16.8%), and “cellulitis” (14/95, 14.7%). Of those readmitted for septic complication related to the joint, 9/22 (40.9%) required revision THA/TKA within 1 year of index surgery. No significant correlation was found between being diabetic and experiencing a septic complication (p=0.510); cardiovascular history and readmission for cardiovascular event (p=0.063), or preoperative ASA ratings and readmit for cardiovascular event (p>0.05); or thrombo-prophylaxis related history and readmission for a thrombo-prophylaxis related complication (p=0.519). The demographic profile of readmitted patients closely mirrors that of all patients who underwent primary TJR at our centre over the same timeframe. Although readmit patients are significantly older (68.3 vs. 71.4 years, p=0.006), this 3 year difference is neither clinically relevant nor clinically significant. Conclusion: The readmission rate among individuals who had a primary TJR was 2.1%. Only 5.3% were readmitted for “failure to cope”. Contrary to our hypothesis, the principle reason for readmission was septic complication related to the operative joint including both superficial and deep surgical site infections which comprised 23% of the sample, and cardiovascular event which comprised 17% of the sample. These diagnoses are reported to be more common postoperative complications associated with total joint replacement. 224: Web-Based Joint Replacement Follow Up Assessments: Are Routine Clinic Visits Necessary in 2011? Steven JM MacDonald, ON; Jacquelyn Marsh, ON; Douglas Naudie, ON; Richard McCalden, ON; James P McAuley, ON; James L Howard, ON; Dianne Bryant, ON Purpose: It has been recommended that patients undergoing total hip, or total knee, arthroplasty be seen for routine followup at regular intervals to monitor the performance of the implant and bearing. However, the vast majority of these followup clinic visits are routine, with no change in clinical outcomes. Technology and resources now exist to enable patient assessment without physically coming to see the surgeon. The purpose of this study was to measure the feasibility and costs associated with a Web-based assessment compared to the usual method of follow-up. Method: We randomized patients who were at least 12 months post-operative to either complete a Web-based follow-up (which included completion of an online form and an xray done at nearest web-enabled facility) or to have their appointment at the clinic as usual. We recorded travel distances, costs, time in xray, time in clinic and time taken off paid employment. Results: A total of 210 patients (96 THA, 114 TKA) completed the study with a mean age of 68.5 years. Patients in the Web-based group travelled less (29.1 vs 110.2 kms, (p<0.01)), had lower associated travel costs ($4 vs $ 21.41, (p<0.01)) and reduced associated time (44.6 mins for online form completion vs 55.6 min clinic visit). Patients missed 5.7 hours from work and caregivers 6.4 hours to attend the clinic appointment. Conclusion: There were significant time and costs savings to patients in the Web-based group. Other potential advantages of Web-based follow-ups include decreased wait times in clinic for existing patients with problems or new patients waiting for surgery, and reduced patient and caregiver burden by decreasing travel distances, financial and time requirements. 225: Assessment of Radiographic Fracture Healing in Patients with Operatively Treated Femoral Neck Fractures Mohit Bhandari, ON; Brad Petrisor, ON; Olufemi Ayeni, ON; Simrit Bains, ON; Rajesh Chakravertty, ON; Meg Chiavaras, ON; Hema Choudur, ON; Naveen Parasu, ON; Sheila Sprague, ON Purpose: The reliability of assessing fracture healing in femoral neck fractures has not been adequately addressed in both research and surgical practice. The purpose of the present study was to determine the reliability of fracture healing assessment and the validity of a novel Radiographic Union Scale for Hip (RUSH) fracture score. Method: A panel of 6 reviewers (3 orthopaedic surgeons and 3 radiologists) independently assessed fracture healing for 150 femoral neck fractures at two separate occasions with a time lapse of 4 weeks to determine inter-rater and intra-rater reliability. Assessment was performed using radiographs for each case at a single time point at various stages of healing. The RUSH score was developed based on the existing criteria and definitions of hip fracture healing, and as such incorporated the assessment of callus bridging and disappearance, trabecular consolidation, and trabecular disappearance. Reviewers used this to score each fracture on a scale from 10 to 30. This would help to determine the validity of using this system to quantify hip fracture healing. Results: Using subjective assessment of fracture healing, the inter-rater agreement between all reviewers for fracture healing was low (intraclass correlation coefficient (ICC) = 0.32, 95% confidence interval (CI): 0.20-0.46) with no significant difference between the orthopaedic surgeon and radiologist groups (0.27 vs. 0.31). There was higher agreement for fracture healing using the RUSH score (ICC=0.63, 95% CI: 0.34-0.79) when compared to physician assessment of healing (ICC=0.37, 95% CI: 0.10-0.59). Intra-rater agreement was consistently high across all measures for both surgeons and radiologists. The RUSH score and medial cortex bridging correlated well with the overall assessment of healing (Pearson’s correlation (r) = 0.868 and 0.643 respectively). 6 of 7 (85.7%) fractures less than two weeks after surgery were deemed healed by reviewers. Conclusion: In the absence of time of xray evaluation, the level of agreement between and within orthopaedic surgeon and radiologist reviewers in the assessment of fracture healing is low, though intra-rater agreement is high. Assessments were improved with the use of a simple radiological checklist (RUSH). Studies evaluating reliability and accuracy of healing with clinical information and temporal evaluation are needed and may improve agreement. 226: Does Weight-bearing Status following Surgery for Hip Fracture Impact Outcomes? Cai Wadden, ON; Steven R Papp, ON; Wade T Gofton, ON; Allan Liew, ON; Alan Forster, ON; Kevn Rasuli, ON Purpose: The purpose of this study was to determine if there was a difference in acute care length of stay (LOS) and complication rates following surgery for hip fracture between patients who were weight-bearing as tolerated (WBAT) and those with an altered weight-bearing (AWB) status. Method: All patients undergoing surgery for hip fracture between January 1st of 2005 and June 30th of 2006 at a single centre were evaluated. Only those patients with an intertrochanteric hip fracture, OTA classification 31-A, were included in the study. Patients who sustained their fracture while admitted to hospital or suffered poly-trauma were excluded. Results: During this 18 month period we identified 130 patients who underwent hip fracture surgery and had an OTA 31-A type fracture. Of these 32% were 31-A1, 62% were 31-A2 and 6% were 31-A3. Overall, 76% of patents were WBAT following surgery with the remaining 24% being either toe-touch weight-bearing (TTWB), partial weight-bearing (PWB) or non weightbearing (NWB). Weight-bearing status did not correlate with either post-operative complication rates or acute care length of stay. Minor complications were greater in the WBAT group compared to the AWB group, 51% versus 32%. Major complication rates were similar between the two groups, 16% in the WBAT group versus 19% in the AWB group. Acute care length of stay was also similar between the WBAT and AWB groups, 13.0 days versus 12.8 days respectively. Failure rates at 12 months were also similar between the groups. Conclusion: Based on this data weight-bearing status does not appear to have a negative impact on acute care length of stay and either minor or major complication rates. Given that almost one quarter of patients have an altered weight-bearing status (NWB, TTWB or PWB) post-operatively without an associated impact on LOS or complications, we are likely over restricting patients weight-bearing status post-operatively and negatively affecting their ability to mobilize. 227: Effect of Starting Position on Distal Cephalomedullary Nail Position for Fixation of Peri-trochanteric Fractures in Osteoporotic Bone George Xenoyannis, ON; Kelly Trask, NS; Ross K Leighton, NS Purpose: Distal anterior cortical perforation is a potential complication with the use of long cephallomedullary nails for peri-trochanteric fractures which occur proximal to the isthmus of the femur. The purpose of this study was to evaluate the effect of sagittal plane start-point for a trochanteric entry femoral nail on distal nail position. Method: This was a biomechanical study conducted on sawbone femurs utilizing an osteoporotic femur bone model. Three different sagittal plane starting points were used with one centrally at the tip of the greater trochanter (M) and the others one centimetre anterior (A), and one centimetre posterior (P) to start point M. Five trials were performed at each entry point using a reamed trochanteric entry antegrade femoral nail inserted according to manufacturer’s instructions. A radiolucent ruler from the nail set was secured to the anterior cortex of femur and fluoroscopy was used to identify at what insertion depth the nail impinged on the anterior cortex of the femur. Impingement was defined as the point the nail could no longer be inserted easily by hand. The final distance from the tip of the nail to the anterior cortex was also measured once the nail was completed seated. The known diameter of the nail was used to adequately scale the radiographs for the measurements taken. Results: With an anterior entry point (A) the average position of the tip of the nail relative to the anterior cortex was 17.2 mm. With a central entry point (M) this distance was 9.6 mm while with a posterior entry point (P) the distance decreased to 3.4 mm. A one-way ANOVA demonstrated a significant difference between the distal position of the nail and proximal entry point (p <0.001). A post-hoc analysis done between paired groups showed that use of a posterior entry point resulted in a significantly more anterior position for the distal end of nail than an anterior (p<0.001) or middle (p<0.001) entry point. There was no impingement on the anterior cortex when start points A or M were used. However, with start point P the nail impinged on the anterior cortex at an average distance of 20.5 cm from the tip of the greater trochanter. Conclusion: This is the first study to determine the effect of an anterior or posterior starting position with a modern nailing system. The saggital plane position of the start point for a femoral nail can affect the distal positioning of the nail. A more posterior start point leads to anterior cortical impingement earlier during nail insertion. In addition, the distance from the tip of nail to the anterior cortex is decreased with a more posterior start point. In osteoporotic bone we recommend a central to just slightly anterior sagittal plane start point for a trochanteric entry femoral nail. 228: Entry Point for Intramedullary Nailing of Femoral Shaft Fractures: A Systematic Review and Meta-analysis Farrah Hussain, ON; Nasir Hussain, ON; Amir Sternheim, ON; Emil H Schemitsch, ON; Paul RT Kuzyk, ON Purpose: Intramedullary (IM) nailing of femoral shaft fractures is an effective treatment method. However, there is debate in the literature concerning the best entry point. The purpose of this meta-analysis was to identify significant differences in outcomes of studies comparing: 1) trochanteric and piriformis entry, and 2) antegrade and retrograde entry in IM nailing of the femur. Method: We searched MEDLINE, COCHRANE and EMBASE, and the Orthopaedic Trauma Association and American Academy of Orthopaedic Surgeons websites for comparative studies published from inception to May 2011. References from relevant articles were also searched. Criteria used to select articles for detailed review included use of antegrade and retrograde entry point or use of trochanteric and piriformis entry point for IM nailing of the femur in adult patients. The following outcomes were extracted from eligible studies: rates of reoperation, dynamization, union, malalignment, nonunion, delayed union, pain, complications, mortality, operative duration, blood loss, and functional outcome in patients with femoral shaft fractures. Results: We found 10 publications and 2 abstracts (2 Level-I, 6 Level-II and 4 Level-III studies) that met the eligibility criteria: 8 comparing antegrade with retrograde entry, and 4 comparing trochanteric with piriformis entry. Pooled data did not indicate significant differences in malalignment, rates of reoperation, union, or non-union/delayed union in either comparison. There were significant differences in pooled data favouring retrograde nailing for operative duration, hip pain and heterotopic ossification, and favouring antegrade nailing for knee pain. There was Level-II and -III evidence showing significant differences in knee function and range of motion favouring antegrade nailing and Trendelenburg gait and blood loss favouring retrograde nailing. No significant differences were found in pooled data for studies comparing trochanteric with piriformis entry. There was Level-I evidence showing significant differences in hip range of motion favouring trochanteric nailing. Conclusion: Although some significant differences were found, the varying quality of studies made recommendation difficult. On the basis of available evidence, it appears that retrograde nailing is favourable in terms of shorter operative duration with risks of knee pain, while antegrade nailing carries risks of hip pain and heterotopic ossification. No reliable conclusions can be made with regards to the entry point for antegrade nailing. Higher level studies using consistent endpoints for comparison are recommended. 229: Open Reduction Internal Fixation vs Acute Total Hip Arthroplasty for the Treatment of Displaced Acetabular Fractures in Older Patients Jonah Hébert-Davies, QC; G Yves Laflamme, QC; Olivier Chemaly, QC; Dominique M Rouleau, QC Purpose: Acetabular fractures in older patients are often the result of low energy trauma with many studies identifying age as an independent factor leading to poor outcome. Standard treatment of displaced acetabular fractures remains open reduction and internal fixation (ORIF) however, there is an emerging subset of patients where ORIF combined with an acute total hip arthroplasty (THA) may be a more reasonable alternative. The purpose of this study was to evaluate and compare the functional outcome of ORIF and THA in the older patients with an acetabular fracture. Method: We conducted a retrospective comparative cohort study at our Level I Tertiary care university hospital. All patients above 50 years old with an acetabular fracture were included. Patients received either open reduction and internal fixation (ORIF) or Acute total hip arthroplasty (THA). Indications for Arthroplasty were: femoral head impaction or fracture, preexisting osteoarthritis, associated femoral neck fracture, posterior wall comminution, roof impaction and severe osteopenia. Functional outcome scores were collected using the SF-12, WOMAC and Harris Hip score. Results: There were 28 patients in the ORIF group and 20 patients in the arthroplasty (THA) group with an average follow-up of 40 months. The two cohorts were comparable except for surgical approach. The mean Harris hip score were not statistically different with 77.9 THA vs 78.9 ORIF. Similarly, there were no significant differences seen in the WOMAC and SF-12 scores (p=0.04). Still a quarter of our patients had significant disability with a HHS under 70 and the need for a walking aid in 5 patients. Surgeries (THA vs ORIF) averaged 152 vs 170 minutes with 992 vs 1128 mL average blood loss (p>0.05). There was an acceptable low rate of major complications with no deep infections but one patient sustained a dislocation that was treated in a brace successfully. The rate of hip replacement in the ORIF group was 8.7%. Conclusion: Open Reduction and Internal fixation and total hip arthroplasty are both useful techniques for treating acetabular fractures in older patients. Our results show that neither has clear superiority. However, either technique used in the appropriate circumstance can be quite successful. 230: Psychometric Analysis of Three Functional Outcome Scores in Tibial Plateau Fractures using the Short Form-36, Short Musculoskeletal Functional Assessment and Western Ontario and McMaster Osteoarthritis Index (WOMAC) Scores Gerard Slobogean, BC; Rupen Dattani, BC; Peter J O'Brien, BC; Henry M Broekhuyse, BC; Piotr A Blachut, BC; Kelly Ann Lefaivre, BC Purpose: There are many general, orthopaedic, and injury specific functional outcome measures available to the orthopaedic researcher. There is little guidance to which measure is best to use in a particular population, and patients can easily be overwhelmed by the time and burden of the collection of multiple functional outcome scores. We aimed to assess the utility and responsiveness of the Short Form Physical Component Summary (SF-36 PCS), the Short Musculoskeletal Function Assessment Dysfunction Index (SMFA DI) & the Western Ontario McMaster Osteoarthritis Index Physical Function (WOMAC PF) in patients treated operatively for tibial plateau fractures. Method: A prospective study between 2005 and 2010 evaluating 55 patients who underwent open reduction and internal fixation for isolated unicondylar split depression tibial plateau fractures. Patients were asked to complete the SF-36, SMFA and WOMAC questionnaires at baseline, 6 months and 12 months post surgery.Correlation between functional outcome measures were calculated using intra-calss correlations. Responsiveness was tested using Standard Response Mean (SRM) , which is the mean score change divided by the standard deviation (SD) of the score change between each time period. The difference in standardized change scores for the SF-36 PCS, SMFA DI and WOMAC PF from 6 to 12 months was compared using a paired t-test. In addition, responsiveness was evaluated comparing number of patients who attained a minimally clinically important difference (MCID), and floor and ceiling effects (10% at lowest or highest level of functioning). Results: The SF-36 PCS, SMFA DI and WOMAC PF scores were highly correlated at baseline, 6 months and 12 months post surgery. The standard response mean (SRM) for the SF-36 PCS was statistically higher than the SRM for the SMFA DI or the WOMAC PF. There was no statistical difference between the SRM for the SMFA DI and the WOMAC PF. Significantly more patients were found to have a minimal clinically important change, between 6 and 12 months post surgery, based on the SF-36 than the other two functional scores. There was no floor effect found on any of the 3 functional scores evaluated; however, a significant ceiling effect was noted with the WOMAC PF but not with the SF-36 PCS or the SMFA DI. Conclusion: In patients with tibial plateau fractures, all three of these functional outcome score are highly correlated, and the SMFA DI and WOMAC PF have a significant ceiling effect at one year. However, the SF-36 PCS is more responsive than the SMFA DI and WOMAC PF. These results, along with the usefulness of the SF-36 for comparing disease burden across populations, recommend the SF-36 as the instrument of choice in assessing functional outcome in patients with tibial plateau fractures. 231: Radiographic Identification of Atypical Subtrochanteric and Femoral Shaft Fractures Lise A Leveille, BC; Penny Brasher, BC; Pierre Guy, BC; Peter J O'Brien, BC Purpose: Atypical subtrochanteric (ST) and femoral shaft (FS) fractures have been increasingly reported in the literature. Their association with long-term bisphosphonate use has been debated. Smaller case series and case-control studies have suggested an association between atypical ST/FS fractures and long-term bisphosphonate use. Some larger, population based studies have not supported this association. In the majority of these larger studies no radiographic review was completed. The purpose of this study was to first, identify the proportion of atypical fractures in patients admitted to a level one trauma center with a lowenergy ST/FS fracture using the American Society of Bone and Mineral Research (ASBMR) radiographic criteria. Second, to quantify the inter-observer reliability of using this method for identification of atypical ST/FS fractures. Finally, to identify the proportion of atypical ST/FS fracture subjects with a history of bisphosphonates exposure. Method: A prospectively collected trauma database was used to identify patients greater than 55 years of age presenting to a level one trauma center with a low-energy ST/FS fracture between January 2000 and February 2011. Exclusion criteria were clinical or radiographic evidence of active malignancy, peri-prosthetic fracture, history of metabolic bone disease, or fracture outside the defined region of interest. Digital radiographs were assessed by three blinded, independent reviewers and categorized as either atypical or non-atypical based on the ASBMR radiographic criteria for atypical ST/FS fractures. A chart review was completed on all atypical fractures. Results: Three hundred and fifty eight ST/FS fractures were identified. Exclusion criteria were met in 195 fractures. Thirty-nine fractures were radiographically categorized as atypical, with an inter-rater reliability (concordance) of 96% and Kappa of 0.92. Of the atypical ST/FS fractures, ten were excluded after chart review for history of metastatic cancer, high-energy mechanism of injury, or Paget’s disease. Of the remaining 29 atypical fractures in 26 subjects, 86% were taking a bisphosphonate at the time of fracture. The average duration of bisphosphonate use was 8.2 years. Conclusion: The majority of low-energy ST/FS fractures are not atypical fractures according to the ASBMR radiographic criteria. Use of database identified cohorts, without radiographic review, results in over inclusion and masking of any association between atypical femoral fractures and long-term bisphosphonate use. Three independent reviewers using the ASBMR radiographic criteria is a reliable means of identifying atypical ST/FS fractures. In this series of atypical ST/FS fractures, the majority had a history of bisphosphonate exposure, which is consistent with previously reported case series. 232: The Incidence and Influence of Distal Ulnar Fractures on Outcomes of Distal Radial Fractures in Women 50 years and Older Geoffrey Johnston, SK Purpose: To determine the incidence of distal ulnar fractures, to characterize them as to their location and to identify their influence of clinical and radiographic outcomes of closed management of distal radial fracture management. Method: Radiographs from 221 women 50 years and over who had undergone closed reduction of a distal radial fracture were evaluated as to the presence of an associated distal ulnar fracture. It, in turn, was assessed as to its location: styloid tip, styloid base, or ulnar neck. The influence of a distal ulnar fracture on three radiographic features (radial inclination, ulnar variance and tilt was assessed, as was its influence on the outcomes of the patient rated wrist evaluation (PRWE) and grip strength. Results: Of 221 distal radial fractures treated by closed reduction and cast management, there were 158 fractures of the distal ulna were identified, for an incidence of 71%. Thirty-seven percent of distal ulnar fractures involved the distal styloid process, 55% the base of the styloid. There were 13 fractures of the ulnar neck, representing 8% of distal ulnar fractures. Distal ulnar fractures, whether styloid tip or basal did not influence either the radiographic or clinical outcomes (PRWE and grip strength) of distal radial fractures when compared to those patients in whom there was no distal ulnar fracture. In the presence of an ulnar neck fracture radial fracture settling, reflected by a diminishing degree of radial inclination, the outcome differed in this group. Whereas end-point radial inclination averaged 19 degrees in the 221 patients, radial inclination averaged 24 degrees in the setting of an ulnar neck fracture. Conclusion: Distal ulnar fractures are associated with distal radial fractures in as many as 70%. Ulnar neck fractures appear to protect against radial settling. 233: Tibial Nail Distal Positioning: A Radiographic Study Travis E Marion, ON; Steven R Papp, ON; Wade T Gofton, ON; Allan Liew, ON Purpose: Intramedullary fixation is the treatment of choice for diaphyseal tibial fractures. The importance of the proper insertion point is well established. Intramedullary fixation of distal tibial fractures relies upon the placement of the guidewire distally to achieve and maintain an acceptable reduction once the intramedullary nail has been inserted. Inappropriate distal positioning of the guidewire may contribute to malalignment when the nail is inserted, leading to malunion, ankle joint dysfunction, and early arthritic changes. The ideal distal position of the guidewire in the distal tibia has yet to be well defined. It was our hypothesis that the ideal guidewire endpoint is lateral to the centre of the ankle joint. Method: Twenty intact tibial radiographs were selected and evaluated. The centre of the medullary canal at the level of the isthmus was established and extended inferiorly through the ankle joint on antero-posterior (AP) and lateral radiographs. Transverse lines of reference on the AP and lateral views were established. The position in which the isthmic line intersected these reference lines was measured and expressed as a percentage from medial to lateral on the AP view and posterior to anterior on the lateral view. Results: AP Radiograph Reference Line Percent From Medial Cortex Maximal Metaphyseal Width 62.0 ± 3.9% Tibial Articular Width 66.5 ± 7.9%Talar Width 63.8 ± 7.8% Lateral Radiograph Reference Line Percent From Posterior Cortex Maximal Metaphyseal Width 42.3 ± 5.3% Tibial Articular Width 37.7 ± 10.6% Conclusion: The ideal placement of the guidewire in the distal tibia for intramedullary fixation of the tibia is not well defined. Traditional teaching usually calls for placement of the guidewire endpoint in the ``centre`` of the ankle joint or distal tibia. Our findings show that the ideal endpoint for an intramedullary nail is lateral and posterior to the centre of the distal tibia articular surface or talus. Positioning of the nail in the ``centre`` may shift the axial position of the talus and contribute to a malreduction, especially in the setting of distal comminution. This study supports further investigations to determine the effect of distal tibial nail malposition and its clinical significance. 234: Vacuum Assisted Closure (VAC) Effects on Skeletal Muscle After Compartment Syndrome in an Animal Model Geoffrey P Wilkin, ON; Shiemaa Khogali, ON; Shawn Garbedian, ON; Brad Slagel, ON; Wade T Gofton, ON; Allan Liew, ON; Jean Marc Renaud, ON; Steven R Papp, ON Purpose: Compartment syndrome is a potentially limb-threatening condition, and residual morbidity may result even with timely fasciotomy. The use of a Vacuum Assisted Closure™ (VAC) device on fasciotomy wounds has been advocated. The effects on the underlying muscle are largely unknown. The purpose of the present study was to evaluate the effects of VAC therapy on skeletal muscle after fasciotomy for compartment syndrome. It was hypothesized that by increasing blood flow to the affected area and by clearing excess intracompartmental fluid, the VAC device would be protective against ongoing muscle fiber damage and would improve the regeneration of damaged fibers after fasciotomy. Method: Compartment syndrome was induced in the hindlimb of 20 young adult female pigs using a previously validated protocol (infusion of porcine serum and continuous compartment pressure monitoring). Fasciotomy was performed after six hours and animals were randomized to receive either wet-to-dry dressings (non-VAC) or VAC dressings for 7 days, followed by delayed primary wound closure. The peroneus tertius muscle (the largest anterior compartment muscle in pigs) and the healthy contralateral muscle were harvested after one week or three weeks for analysis. Results: At one week, compared to the unaffected side, muscle weights were 130% greater for the VAC treated muscles, and 93% greater for non-VAC treated muscles. This suggested more fluid accumulation in the VAC treated muscles. Histological measurements showed less than 2% of the total cross-sectional area had exclusively intact muscle fibers. Most of the observed sections contained either intact fibers surrounded by mononucleated cells or only mononucleated cells (i.e. no intact fibers). VAC treated muscles had a greater surface area containing only mononucleated cells compared to non-VAC treated muscles. At 3 weeks, the weights exceeded the unaffected side by 26-27% and intact fibers constituted 80% of the total surface area examined in both treatment groups. Within those areas, VAC-treated muscles showed a greater proportion of mononucleated cells between fibers than in non-VAC treated muscles. Conclusion: VAC and non-VAC treated animals show initial muscle fiber damage in a compartment syndrome model. This showed improvement after 3 weeks. In this model, VAC treatment did not appear 235: A Novel Process for Anatomic Measurement of the Proximal Ulna to Guide Prosthesis Design Ian Pereira, ON; Bashar Alolabi, ON; Alia Gray, ON; George S Athwal, ON; James A Johnson, ON; Graham JW King, ON Purpose: Deficiency of the articular surface of the proximal ulna as a consequence of fractures may lead to elbow instability and post-traumatic arthritis. However, there are currently no available implants to address isolated bony deficiencies of the proximal ulna. Although total elbow replacement is an option, current elbow prostheses do not perform as reliably as prostheses of other joints. A better understanding of the precise morphology of the articular surface of the proximal ulna should assist in the development of improved designs of both partial and total elbow joint prostheses. The aim of this study was to develop a novel technique to better characterize the morphology of the proximal ulna to guide improved prosthetic designs. Method: Thirty-two cadaveric elbows were imaged by computed tomography, segmented into a 3-dimensional reconstruction of the proximal ulna using Mimics medical image processing software, and imported into Solidworks 3D engineering measurement and design software. Custom software interfaced with Solidworks allowed accurate and efficient identification and measurement of characteristics of 66 significant articular features of the greater sigmoid notch, coronoid, and olecranon of each specimen. Results: The average coronoid guiding ridge radius of curvature was greater than that of the olecranon (10.8+/-2.0mm, 9.9+/-1.9mm, p=0.2). The angle of the coronoid guiding ridge to the total guiding ridge was medially rotated with respect to the angle of the olecranon guiding ridge to the total guiding ridge (10.9+/-7.2 degrees, -9.8+/-7.7 degrees, p<0.05). The coronoid height was larger than the olecranon height (16.5+/-2.2mm , 7.7+/-1.3mm, p<0.05). The bare area width was 5.5+/-2.0mm, and the surface length was 5.7+/-1.9mm. The coronoid medial articular surface was concave compared to the convex lateral facet, although the surface angles of both increased to a maximum at 50% of the coronoid height from the tip before decreasing to a minimum at the coronoid base. The rate of increase of coronoid depth below 50% of the coronoid height was less than that above 50% (0.17+/-0.01mm/%, 0.42+/0.2mm/%, p<0.05). Conclusion: Prostheses of the elbow have been limited in their performance, in part due to a lack of understanding of the anatomic complexity of the proximal ulna. This study described an effective and efficient process to better characterize significant anthropometric features of the proximal ulna. This data has recently been used to design a novel coronoid prosthesis. Future studies are planned to further assess the performance of this prosthesis and design improved implants for replacement of the proximal ulna. 236: Anatomical Repair of the Distal Biceps Tendon May not be Possible Through a Single Anterior Incision Greg W Hansen, ON; J W Pollock, ON; Joel M Werier, ON; Kawan Rakhra, ON; Steven R Papp, ON Purpose: The biceps muscle is an important flexor and supinator of the elbow. When distal biceps tendon ruptures occur, surgery is often performed in order to restore normal strength. The single incision approach has gained significant popularity and it is commonly used in our institution. Through a single anterior incision, the radius is exposed and the tendon is repaired to the bicipital tuberosity using suture anchors. However, the anatomic footprint of the biceps tendon is located ulnar on the bicipital tuberosity. This makes an anatomic repair difficult through this approach. We hypothesized that an anatomic repair of the distal biceps tendon cannot be consistently achieved utilizing a single anterior approach with suture anchors. Method: Twenty-seven retrospective, post-operative CT scans were obtained on patients’ operative elbows that had biceps tendon repairs performed using a single anterior incision and suture anchor fixation. Using axial images of the distal radius, the sagittal axis of the radius was determined, and the position of the bicipital tuberosity apex was referenced relative to this axis. In a similar fashion, the position of both the proximal and distal suture anchors (representing the site of tendon repair) was measured and referenced from the tuberosity apex. Results: All patients were male with an average age of 47 years (range 35 – 66). There were 13 left sided and 14 right sided repairs. The apex of the bicipital tuberosity was located ulnar from the mid-sagittal radial axis an average of 55.6 degrees (range 43-67 deg). The proximal anchors were positioned radially from the tuberosity apex an average of 52.5 degrees (range 6 – 98 deg) while the distal anchors were positioned radially by 50.4 degrees (range 12 – 117 deg). Conclusion: In this group of patients who had undergone suture anchor repair through a single incision technique, the distal biceps tendon was commonly repaired to a nonanatomic position on the bicipital tuberosity. The repair was often positioned radial from the bicipital tuberosity apex. This could lead to significant weakness, particularly with supination. When performing a biceps repair through a single incision technique, surgeons should pay attention to the position of the repair site. In some cases, it may not be possible to anatomically repair the biceps tendon to the ulnar aspect of the bicipital tuberosity through a single incision approach. Further strength testing and validated outcome scores are required to determine if this malpositioning results in a clinically detectable deficit. 237: Comparing the Extensor Digitorum Communis Splitting Approach to the Posterolateral Kocher Approach: A Novel Method of Measuring Articular Surface area William Desloges, ON; Hakim Louati, ON; Steven R Papp, ON; J W Pollock, ON Purpose: Currently, the most widely used lateral approach to the elbow is the posterolateral, or Kocher approach. It is believed that the extensor digitorum communis (EDC) splitting approach allows easier access to the more commonly fractured anterior hemisphere of the radial head while minimizing the risk of injuring the lateral ulnar collateral ligament. The aim of this cadaveric study was to compare the visible bony and articular surface area procured by the EDC splitting, and the posterolateral Kocher approaches. Secondarily, we aim to compare the extended EDC splitting approach to the extended Kocher approach. Method: The following approaches were concurrently performed on six fresh frozen cadaveric upper extremities: the EDC splitting approach, the Kocher approach, and the extensile EDC splitting approach. The extensile Kocher approach was also performed on four specimens. The visible bony and articular surface areas were outlined using a burr for each approach. Then, bones were stripped of all soft tissues for analysis. Each bone was converted into a digitized 3D model using the DAVID Laserscanner system (Koblenz, Germany). Using the markings created by the burr, the visible surface area obtained for each approach was mapped and quantified. Results: The EDC splitting approach provided a greater percentage of visible surface area to the anterior half of the radial head as compared to the Kocher approach (median 100% and 68%, respectively; p = 0.03; Wilcoxon signed-ranks test). The anterolateral quadrant of the radial head was equally well visualized with both the Kocher and EDC splitting approaches. The extended Kocher and extended EDC splitting approaches procured comparable visualization of the distal humerus, the radial head and coronoid process. Conclusion: Although the EDC splitting and Kocher approaches both adequately exposed the commonly fractured anterolateral quadrant of the radial head, the EDC splitting approach offered a significantly greater exposure to the whole anterior half of the radial head. Therefore, we recommend using the EDC splitting approach to reliably visualize fracture lines, in the reduction and fixation of partial articular radial head fractures. Furthermore, using the EDC splitting approach minimizes the risk of injuring the ulnar lateral collateral ligament, which is a primary constrain to posterolateral rotatory instability. 238: Distal Humerus Hemiarthroplasty: The Effect of Implant Sizing on Elbow Joint Kinematics Sagar J Desai, ON; George S Athwal, ON; Louis M Ferreira, ON; James A Johnson, ON; Mark Welsh, ON; Emily Lalone, ON; Graham J W King, ON Purpose: Distal humeral hemiarthroplasty is a novel treatment for distal humerus fractures, non-unions and avascular necrosis. The biomechanical effects, however, have not been reported. The purpose of this in vitro study was to quantify the effects of distal humeral hemiarthroplasty and implant size on elbow joint kinematics. Method: Eight fresh-frozen cadaveric arms were mounted in an elbow testing system, which simulated active and passive flexion in the dependent, horizontal, varus and valgus positions. Kinematic data, including varus-valgus angulation and ulnohumeral rotation, were obtained using an optical tracking system. An olecranon osteotomy was performed to access the joint and a custom distal humeral stem was implanted under image-guided navigation. Three humeral spools were evaluated for kinematics: the optimal sized spool, under-sized and oversized. Statistical analysis was performed using repeated measures analysis of variance. Results: Hemiarthroplasty altered joint kinematics, regardless of implant size during both active and passive motion. In the valgus position, the optimally sized implant resulted in a mean increase in valgus angulation of 3.5º ± 1.7º (p < 0.05) as compared to the native elbow. In the varus position, the optimal and undersized implants both resulted in significant (p < 0.05) increases in varus angulation, 2.6º ± 1.4º and 3.2º ± 1.2º, respectively. The under-sized implant had the greatest alteration in kinematics while the over-sized implant best reproduced kinematics of the native elbow. In the varus position, during active and passive motion, kinematics of the over-sized implant were not significantly different from the native elbow (p > 0.05). Conclusion: An optimally sized distal humeral hemiarthroplasty caused significant increases in varus-valgus laxity and ulnohumeral rotation. This could be secondary to differences in the shape of the humeral implant relative to the native elbow. The under-sized implant demonstrated the greatest alteration in kinematics, while the over-sized implant best reproduced native elbow kinematics. This suggests that when uncertainty exists in size selection, the larger implant may be better at increasing post-operative stability. Future hemiarthroplasty studies are required to determine optimum articular contact, joint forces, and implant articular shape. 239: Measurements of the Ispilateral Capitellum can Reliably Predict the Diameter of the Radial Head Alexandre Leclerc, QC; Sagar J Desai, ON; Simon Deluce, ON; Louis Ferreira, ON; Graham JW king, ON; George S Athwal, ON Purpose: Presently, there is no validated method to determine the correct diameter of a radial head implant when the radial head is too comminuted to function as a template, or during revision surgery when the native radial head has been previously excised. The purpose of this CT-based morphology study was to determine if ipsilateral capitellar dimensions could be used to predict the diameter of a radial head implant. Method: Computed Tomography (CT) scans of 30 elbows were used to generate three dimensional (3D) models of the humerus and radius in MimicsTM (Materialise). Measurements of the radial head included the maximum diameter (Dmax), the minimum diameter (Dmin) and the diameter of the articular dish (Ddish). Measurements of the distal humerus included the width of the capitellum (CAPwidth), and the width from the lateral aspect of the capitellum to the lateral trochlear ridge (CAPridge). Pearson bivariate correlations were determined between humeral and radial head dimensions. Results: The mean radial head dimensions were Dmax = 24.2±2.5 mm, Dmin = 22.9±2.4 mm and Ddish = 18.0±2.2 mm. The mean capitellar measurements were CAPwidth = 18.0±1.4 mm and CAPridge = 22.5±2.3 mm. The most significant correlations were found between Dmax and CAPridge (r=0.922, p<0.001), Dmin and CAPridge (r=0.906, p<0.001), and Ddish and CAPwidth (r=0.784, p<0.001). Conclusion: Measurements of the ispilateral capitellum appear to be useful in the estimation of native radial head diameter. The CAPridge width was very strongly correlated with the maximum and minimum diameters of the radial head and was superior to the CAPwidth. This suggests that CAPridge width may be useful to accurately predict the native radial head diameter. These morphological relationships could be plotted to produce an implant selection chart for radial head sizing applicable to any implant system. The CAPridge width, measured from the lateral aspect of the capitellum to the trochlear ridge, can be measured preoperatively on a CT scan, or intra-operatively using a ruler or callipers. Thus, measurements of the ispilateral capitellum can be used to reliably estimate the diameter of the native radial head and therefore should allow the surgeon to more accurately predict the optimal diameter of a radial head implant in the circumstances where the native radial head is either unavailable or unsuitable to assist with implant sizing. 240: Radial Head Instability Following Malreduction of the Proximal Ulna: A Biomechanical Assessment Emilie Sandman, QC; Fanny Canet, QC; Yvan Petit, QC; G Yves Laflamme, QC; George S Athwal, ON; Dominique M Rouleau, QC Purpose: Malreduction of the ulna following proximal ulnar fractures, such as Monteggia injuries, may lead to arthrosis and instability. Malunion of the proximal ulna dorsal angulation (PUDA) has been implicated in malalignment of the radiocapitellar joint. Thus, the purpose of this biomechanical study was to evaluate the magnitude of ulnar malreduction at the PUDA that would be necessary to cause radial head instability, with and without a simulated annular ligament injury. Method: Six fresh frozen upper extremities were mounted on a motorized elbow motion simulator. To reproduce a proximal ulnar fracture, an osteotomy at the PUDA site was completed on each specimen. Fixation of the osteotomy was conducted with 5 variable angle plates (-10°, -5°, 0°, 5°, 10°) to reproduce malunions. Lateral elbow radiographs were taken with fluoroscopic assistance in 4 elbow positions (maximal extension, 45°, 90°, maximal flexion) and three forearm positions (neutral, pronation, supination). The protocol was initially done with the annular ligament intact and was repeated after a simulated annular ligament injury. Radial head instability was measured as a ratio of the displacement of the radial head on the capitellum, and was termed the Radio-Capitellum Ratio (RCR). Results: Significant interactions exist between elbow positions, angles of malunion and annular ligament integrity when evaluating radial head stability with the RCR measurement (p<0.001). With increasing extension malunion of the proximal ulna, the radial head progressively translates anteriorly on the capitellum (p=0.002), with the mean displacement ranging from 11% to 14% when the annular ligament is intact and from 23% to 57% with the annular ligament sectioned. The greatest ratios of radiocapitellar instability where seen when the annular ligament was sectioned (p<0.001). Anterior translation of the radial head also increased as the elbow moved from extension to flexion (p<0.001). The mean radial head displacement was 70% when the elbow was in maximal flexion, reduced at -10° and with the annular ligament ruptured. Conclusion: Malalignment of the proximal ulna directly affects elbow biomechanics and stability, especially the radial head when the annular ligament is insufficient. Thus, this study demonstrates the importance of anatomic alignment of the proximal ulna, particularly recreation of the proximal ulna dorsal angulation, to ensure correct radiocapitellar relationships. 241: Reliability of the Modified Mason Classification for Radial Head Fractures - A Comparison of Plain Radiographs versus CT Michael Gladwell, ON; Yishai Rosenblatt, IR; George S Athwal, ON; Ruby Grewal, ON; Graham JW King, ON; Kenneth J Faber, ON Purpose: Radial head fractures are commonly classified using the Broberg and Morrey modification of the Mason classification (modified Mason classification), a radiograph-based system that has been found to have moderate inter-observer reliability that can be improved with the addition of external rotation oblique radiographs. The reliability of the modified Mason classification using computed tomography has not been established. We hypothesized that CT scan, including 3D reconstruction, would improve inter- and intra-observer reliability of the modified Mason classification. Method: Fifty-four patients with acute radial head fractures were included in the study. All had AP and lateral radiographs and a CT scan with 3D reconstructions. Twenty-four had a Greenspan radial head-capitellum view. Five observers (two orthopaedic residents, two upper extremity orthopaedic fellows, and an upper extremity surgeon) classified each case according to the modified Mason classification. Cases were classified four times, based on the AP and lateral, AP/lateral and Greenspan, CT scan, and 3D reconstruction. Four of the observers repeated the classification one week later. Fleiss’ kappa values for inter-observer reliability, and Cohen’s kappa values for intra-observer reliability were calculated. Values were compared among different imaging types and observers using a one-way ANOVA. Results: The kappa values for inter-observer reliability based on AP and lateral, AP/lateral and Greenspan, CT, and 3D reconstruction were 0.46 (95% CI 0.40-0.52), 0.35 (0.25-0.44), 0.42 (0.36-0.48) and 0.42 (0.36-0.48) respectively. The kappa values for intra-observer reliability were 0.67 (0.58-0.76), 0.64 (0.50-0.79), 0.63 (0.53-0.73) and 0.64 (0.55-0.73) respectively. There was no significant difference in inter-observer reliability among imaging techniques, and no difference in intra-observer reliability among imaging techniques or observers (p>0.05). Conclusion: The inter-observer reliability of the modified Mason classification was moderate and the intra-observer reliability was moderate to substantial according to the criteria of Landis and Koch. Level of training did not affect the intra-observer reliability. The results of this study are comparable to previous studies using plain radiographs. CT scan and 3D reconstruction did not improve inter- or intra-observer reliability. The additional detail offered by CT often made classification more difficult, since this extra detail does not fit into the modified Mason classification. The CT helps to better understand the fracture pattern, especially type two and three fractures, which often have multiple small fragments, however further studies are needed to determine whether this additional information improves patient outcomes. Further modification of the classification, based on CT, may improve reliability and help direct treatment. 242: The Lateral Paraolecranon Approach for Total Elbow Arthroplasty Alexis Studer, ON; George S Athwal, ON; Joy C MacDermid, ON; Kenneth Faber, ON; Graham JW King, ON Purpose: The purpose of this study was to describe and evaluate the lateral paraolecranon approach, a modification of a triceps splitting approach, for total elbow arthroplasty (TEA) and to compare it to the paratricipital and triceps splitting approaches. Method: This study evaluated 34 patients that underwent TEA; 25 with rheumatoid arthritis (28 elbows) and nine fracture cases. Of the 28 elbows with RA, 17 underwent a triceps splitting approach, six a lateral paraolecranon and five a paratricipital approach. Of the nine fracture cases, five patients underwent a lateral paraolecranon approach and four were operated through a paratricipital approach. Extension strength, range of motion, elbow function (Mayo Elbow Performance Index), and complications related to triceps insufficiency were compared for all three approaches. Additionally, the lateral paraolecranon and paratricipital approaches were compared to the contralateral healthy elbow in the nine fracture cases. Results: Patients with rheumatoid arthritis had better extension torque when the prosthesis was implanted through the lateral paraolecranon approach (20.1±7.6 Newton-meters), when compared to the triceps splitting approach (13.1± 4.3 N-m) or the paratricipital approach (12.3±6.2 N-m) (p< 0.01). The elbow extension strength according to the MRC scale was significantly higher for the groups where the triceps was not detached (paratricipital and lateral paraolecranon approach) when compared to the triceps splitting approach (p<0.05 and p< 0.001, respectively). There was one case of triceps insufficiency in the triceps-splitting group and none in the paratricipital or lateral paraolecranon approaches. In the fracture group, the extension strength of the replaced elbow was similar to that of the contralateral normal elbow with both the paratricipital and lateral paraolecranon approaches. Patients with rheumatoid arthritis who had a triceps splitting approach had less extension (43.7º±16º) than those who had a lateral paraolecranon (15.8º±12.1º) or triceps-on approach (23.6º±10.3º) (p<0.05). There were no differences in flexion range in patients with rheumatoid arthritis (p>0.05). There was no effect of the surgical approach on both flexion and extension range in the fracture group (p>0.05). The average MEPI score for the patients with R.A. (86.4±11.7 points) was not significantly different (p=0.63) from the group with traumatic conditions (89.4±15.9 points). Conclusion: The lateral paraolecranon approach can provide equal or better strength and functional outcomes, in comparison to more traditional elbow approaches. The lateral paraolecranon approach avoids triceps tendon detachment and repair to the olecranon, thereby reducing the risk of triceps insufficiency while maintaining extension strength. The lateral paraolecranon approach allows for improved ulnar visualization when compared to the paratricipital approach; however, ulnar visualization is still compromised when compared to other triceps detaching/reflecting approaches. 243: Ulnar Placement of the Distal Biceps Tendon During Repair Improves Supination Strength - A Biomechanical Analysis Marc Prud'homme-Foster, ON; JW Pollock, ON; Hakim Louati, ON; Steven R Papp, ON Purpose: Repair of distal biceps tendon rupture requires reestablishing its insertion site on the radial tuberosity. Based on anatomical studies it has been suggested that the heads should be inserted on the ulnar aspect of the footprint. The effect of insertion repair site on the footprint has not previously been studied. This study examines the effect of the repair site on forearm supination strength, and provides biomechanical evidence for ideal insertion placement. Method: Twelve fresh-frozen cadaveric arms were secured using an in vitro elbow simulator and a two-head repair was performed in ulnar and radial locations on the radial tuberosity. Isometric supination torque and elbow flexion force were recorded with the forearm in 45 degrees supination, neutral rotation and 45 degrees pronation. Results: In all specimens elbow flexion strength was not affected by - biceps repair in the ulnar or radial configuration on the tuberosity. Forearm supination was significantly stronger with a more ulnar insertion placement on the tuberosity. While the difference in was less pronounced in pronation, radial placement resulted in a mean drop of 78% (p<0.05) in supination strength with the arm in 45 degrees of supination. Conclusion: Studies of the distal biceps tendon insertion sites have suggested a welldescribed footprint on the radial tuberosity. The effect of the repair site on supination strength, to our knowledge, has never been studied. This biomechanical study suggests that insertion site placement on the tuberosity affects forearm strength. A more ulnar repair site on the tuberosity resulted in improved supination strength. This highlights the importance of achieving an ulnar distal biceps tendon repair. 244: Validity of Magnetic Resonance Imaging in Detecting Biceps Pathology Simon Fournier-Gosselin, QC; Helen Razmjou, ON; Richard Holtby, ON Purpose: Role of MRI in detecting long head of biceps (LHB) pathology has been questioned by previous studies, in which biceps pathology was examined in patients with general shoulder pain or rotator cuff tears. The purpose of present study was to examine the accuracy of MRI in detecting biceps pathology as the primary finding in patients who had arthroscopic evidence of pathology in the biceps tendon. Method: Prospectively collected surgical data were extracted from a research based database in which biceps pathology was classified as partial tear, dislocation /subluxation, or complete rupture. The MRI was conducted in the same institute where the surgery was performed. All images had been interpreted by one of three radiologists with training in musculoskeletal disorders. The data extraction form that categorized MRI findings was extracted by an orthopedic fellow from the electronic MRI report. Associated pathologies in rotator cuff and or labrum were reported for descriptive purposes. Sensitivity, specificity and likelihood ratios were calculated. Results: Data of 116 patients with biceps pathology [77 men (66%), mean age=63, range 3784)] who had undergone arthroscopic surgery over a period of 6 years were used for analysis. Prevalence of complete biceps rupture was 36 % in all patients with documented biceps pathology. Prevalence of partial thickness biceps tears and subluxation/dislocation was 75% and 9% respectively. Superior labral pathology had a prevalence of 30% (15% SLAP type I, 12% type II, and 3% type III) with 79% (92) of patients having a full thickness tear of rotator cuff. Sensitivity (true positives rate) of MRI was 0.39 for full rupture and specificity (true negative rate) was 0.98. Sensitivity and specificity were 0.16, and 0.80 for partial thickness tears, and 0.89 and 0.84 for dislocation and or subluxation respectively. Positive Likelihood Ratio and negative Likelihood Ratios were 16 (large change in probability of having a pathology) and 0.63 (insignificant change) for full ruptures, 0.82 and 1.04 (insignificant change) for partial thickness tears, and 5.59 and 0.13 (moderate change) for dislocation/subluxation. Conclusion: MRI is a highly specific diagnostic test for ruling in a full-thickness biceps tear but is not a sensitive tool for ruling out a full biceps tear. Subluxation/dislocation of the biceps can be moderately ruled in and ruled out. Partial-thickness tears of the biceps tendon are not reliably diagnosed with MRI.