CENEGENICS MUSCLE FORMULA

CENEGENICS MUSCLE
FORMULA
Sarcopenia, Myostatin, and the Role of
Fortetropin
from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health
THERE IS A SIGNIFICANT AMOUNT OF RES EARCH EXAMINING MUSCLE AND ITS IMPORTANCE
IN OVERALL HEALTH. Everyone Recognizes That Muscle Is Important For Its Role In Movement And Physical Activity.
Most Individuals Do Not Know It Also Has Important Metabolic Functions. Studies Show That Lean Muscle Mass Is A Key
Marker For Overall Health And Longevity. There Are Several Ways To Improve Muscle Mass And Function. Diet, Exercise
And Hormonal Factors All Play Important Roles In Maintaining And Increasing Muscle.
WE NOW RECOGNIZE THAT MYOSTATIN ALSO PLAYS A ROLE. MYOSTATIN IS A PROTEIN IN
OUR BODY THAT PREVENTS MUSCLE GROWTH. Myostatin Levels In The Body Increase As One Ages. Research
Now Suggests That Inhibiting Myostatin Improves Muscle Mass And Function. It Has Also Been Found That Using
Testosterone Increases Myostatin Levels In The Body. We Know Testosterone Increases Muscle Mass But It Also Increases
Myostatin Levels. The Ability To Inhibit Myostatin In Individuals Using Testosterone May Improve Gain In Lean Muscle And
Has The Potential To Reduce Testosterone Doses One Needs To Take.
CENEGENICS’ NEW MUSCLE FORMULA IS A NATURAL MIXTURE OF PROTEINS, LIPIDS, P EPTIDES
AND OTHER BIOACTIVE MOLECULES DERIVED FROM FERTILIZED CHICKEN EGG YOLK AND
PROCESSED IN A WAY THAT RETAINS THE BIOLOGICAL ACTIVITY OF THESE INGREDIENTS. These
Ingredients Are Known To Have Pro-Myogenic And Anti-Inflammatory Effects. They Bind To Myostatin And Prevent It From
Inhibiting Muscle Growth. Clinical Data Demonstrates These Active Ingredients Reduce Serum Myostatin Levels In Human
Subjects. This Is An Oral Supplement Taken Once A Day. There Are No Known Side Effects. Individuals With Egg Allergies
Should Not Take This, As This Is An Egg-Based Product.
CENEGENICS’ MUSCLE FORMULA IS AN IMPORTANT SUPPLEMENT TO A BALANCED APPROACH
TO IMPROVE LEAN MUSCLE MASS AND HEALTH ALONG WITH DIET, EXERCISE AND HORMONES.
Call Cenegenics Now. 480.454.2370
CENEGENICS MUSCLE FORMULA FAQS
MUSCLE FORMULA – HOW IT WORKS The Key Active Ingredient In The Cenegenics Muscle Formula Is Fortetropin, Which Functions As A Modulator And Antagonist Of Myostatin Production. Muscle Formula Contains A Complex
Mixture Of Proteins, Lipids, Peptides And Other Bioactive Molecules Derived From Fertilized Chicken Egg Yolk Pasteurized
Using A Proprietary Process That Retains The Biological Activity. Certain Moieties In This Mixture Impart Their Pro-Myogenic Activity Through Action On The Tgf-Β Signaling Pathway.
SUPPLEMENT FACTS/INGREDIENTS LIST Is The Cenegenics Muscle Formula A Hormone Or Involved With Hormone Replacement Therapy (Hrt)? The Main Ingredient In The Cenegenics Muscle Formula Is Fortetropintm, A Natural
Dietary Supplement Developed To Improve Muscle Strength And Quality. It Is Not A Hormone Or Involved With Hrt.
Is This Product Animal Or Plant Derivative? This Product Is Derived From Fertilized Chicken Egg Yolk And Composed Of
Proteins, Peptides And Lipids.
Are There Any Drug And/Or Allergic Interactions? There Are No Known Drug Interactions But Individuals Who Are Allergic
To Egg Or Egg-Based Product Should Avoid Muscle Formula.
Who Can Take The Cenegenics Muscle Formula? All Adults Over The Age Of 18 Can Take It.
Do Responses Differ In Men And Women? Myostatin Is Found In Both Men And Women And Its Suppression Appears Be
Similar. We Have No Evidence That It Works Differently In Men And Women. Using Muscle Formula To Decrease Myostatin Levels Should Have Similar Impacts With Respect To Myostatin Action In Both Men And Women.
What Is The Dose? Current Recommendation Is 20 Grams (One Pouch) Daily
WHAT IS THE COST?
$250 Per Box Of 30 Pouches
Free Shipping
$200 Per Box If 12 Or More Are Purchased At One Time
HOW LONG DOES EACH BOX LAST? 30-Day Supply Per Box (If Taken Once Daily)
WHAT IS THE SHELF LIFE? 24 Months
What Is The Best Way To Take The Muscle Formula? It Can Be Eaten As A Dry Powder. You Can Also Prepare As A Drink
My Mixing One Pouch In Approximately 6-8 Fluid Ounces Of Cold Water And Consuming Immediately. For Best Consistency Mix In A Blender For 20-30 Seconds.
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Cenegenics Muscle Formula | Call 480.454.2370 to order!
Loss of muscle mass is detrimental to your
overall strength and vitality. Let Cenegenics
get you back on track!
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Sarcopenia
The Problem
patients’ sense of well-being, sexual function, lean
body mass and muscle strength, bone mineral
density and cognition
SARCOPENIA:
•Age-related loss of lean muscle mass, strength, and
functionality
•Multifactorial disease process that may result from
suboptimal hormone levels, inadequate dietary
protein, nutritional imbalances, lack of exercise,
oxidative stress, and inflammation
•In men treated with graded doses of testosterone,
myostatin levels were significantly higher in both
young and older men
•Muscle mass loss 0.5-1% per year
•Changes in myostatin levels were significantly
correlated with changes in total and free
testosterone
CAUSES OF SARCOPENIA:
•Nutrition—Decreased protein/amino acid intake
TARGET OPPORTUNITY—MYOSTATIN
INHIBITION:
•Activity—Physical, Inactivity, Immobility
•Endocrine—Age-Related Decline in Hormone levels
(testosterone,GH,IGF-1)
•Myostatin inhibition appears to potentiate or
augment the effects of testosterone resulting in
improved lean muscle gains and retention
•Inflammation—Elevation of cytokines (IL-6, TNFalpha)
•Important component as part of testosterone
therapy
CURRENT MANAGEMENT OF SARCOPENIA:
•Used as a stand alone therapy for muscle health
1.Exercise—Resistance training
GENETIC FOUNDATION:
2.Nutrition—Dietary intake of essential proteins
3.Therapeutics—Growth Hormones, Testosterone
4.Natural Supplemental Support—Myostatin inhibition
•Critical metabolic hormone in aging
•Beneficial effects on mood, energy levels and
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TESTOSTERONE/MYOSTATIN (MOL CELL
ENDOCRINOL. 2009;302(1):26–32):
•Found to increase myostatin level in human subjects
•Muscle quality loss 2.5% per year
TESTOSTERONE:
•Declines with age
•The gene encoding myostatin was discovered in
1997
•This gene was named myostatin for its ability to
inhibit muscle differentiation and growth
•Myostatin (also known as growth differentiation
factor 8, abbreviated GDF-8) is a protein that in
humans is encoded by MSTN gene
Cenegenics Muscle Formula | Call 480.454.2370 to order!
Don't let Sarcopenia drain away your mobility
and functionality. Take action today and
regain your strength.
Cenegenics Muscle Formula | Call 480.454.2370 to order!
5
Myogenesis
OBSERVATIONS:
•Increase in myostatin as a consequence of obesity compromises skeletal muscle health and systemic metabolism
in a high proportion of older persons.
•Inhibiting myostatin may provide an effective means to simultaneously improve their physical function and
metabolic health
•Inhibition of myostatin in adult and older animals significantly increases muscle mass and confers benefits upon
measures of performance and metabolism.
MYOSTATIN INCREASES AS A RESULT OF AGING AND OBESITY (WHITE TA, LEBRASSEUR NK.
GERONTOLOGY. 2014 JAN 17. DOI: 10.1159/000356740):
•An increase in serum myostatin as a result of aging and obesity compromises skeletal muscle health and
metabolism in aging adults
•Inhibiting myostatin may provide an effective means to simultaneously improve their physical function and
metabolic health
Myo statin Inhibition Has a Positive Impact on
Several Aspects of Health:
REDUCTIONS IN SERUM MYOSTATIN ARE ASSOCIATED WITH:
IMPROV EMENT IN AGE-RELATED REDUCTIONS IN:
•Muscle mass and fiber cross-sectional area
•Declines in bone mineral content and density
•Declines in cardiac ejection fraction
REDUCED:
•Glucose and triglycerides
•Fat mass, macrophage infiltration and inflammation
•Ectopic lipid accumulation in the liver
•Aortic atheromatous lesions in mice genetically predisposed to atherosclerosis
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Feel stronger and be more active. Increase
y our muscle mass and live your life!
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FORTETROPIN:
•Unique suppressor of serum myostatin
•Myostatin inhibition maintains muscle health
•Decrease muscle loss
•Improves function and vitality
Fortetropin Reduces Serum Myostatin in
Humans
•Study Design: Double blind, randomized, placebo-controlled, parallel, single-dose
•Dose Administration: 10 grams of Fortetropin mixed with vanilla fat free/sugar free pudding for active arm; 10
grams of vanilla fat free/sugar free pudding alone for placebo arm.
•A single dose of Fortetropin resulted in substantial reduction in serum Myostatin concentration over a 24 hour
period
MUSCLE HEALTH MULTIFACTORIAL APPROACH:
•Diet / Supplements
•Exercise
•Hormonal
•Target each pathway in process
•Individual support for diet and exercise
•Therapeutics
•Myostatin inhibition
•Testosterone
•Growth Hormones
ADDITIONAL OPTIONS:
•Supports muscle health in conjunction with testosterone
•Provides a testosterone-free alternative
•Individuals who choose not to undergo therapy
•High risk cardiac population
•Women
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Cenegenics Muscle Formula | Call 480.454.2370 to order!
Get back on top of things and feel
unstoppable. Don't let loss of muscle mass
slow you down.
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9
CURRENT RESEARCH:
•Effects of Fortetropin on blood chemistry in women
•Effects of Fortetropin on Lean Body Mass, Strength, and Power in Resistance Trained Males
•Effects of Fortetropin and Testosterone on lean muscle and fat mass in an animal model
CENEGENICS RESEARCH:
•Opportunity for research and publishing
•Protocols to monitor multiple therapies
•Dexa Scans
•VO2 max
•Muscle function tests
•Customized system to deliver care and collect data
FUTURE PRODUCT GROWTH:
Female product line
Specialized formulations in muscle health
Partnership in scientific research and development
MUSCLE FORMULA IS POWERED BY FORTETROPIN, A PROPRIETARY FORMULA AND THE
WORLD’S ONLY CLINICALLY PROVEN MODULATOR OF MYOSTATIN IN THE BODY.
Sarcopenia, Myostatin, and the Role of Fortetropin
SARCOPENIA, THE GRADUAL LOSS OF SKELETAL MUSCLE MASS, STRENGTH AND FUNCTION
WITH ADVANCING AGE, REPRESENTS A SIGNIFICANT THREAT TO INDEPENDENCE AND
QUALITY OF LIFE. There is significant interest in understanding the biology of sarcopenia and developing
therapeutic interventions to prevent, slow or reverse its progression 1. Myostatin is a protein found in humans and which
plays an important role in regulation of skeletal muscle development. This secreted growth factor, expressed mainly
in skeletal muscle but also in adipose tissue, is a potent negative regulator of skeletal muscle mass. Mice in whom the
gene for myostatin has been removed have a dramatic increase in muscle mass, reduction in fat mass, and resistance
to diet-induced and genetic obesity. Results in animal models have shown that inhibition of myostatin with injectable
compounds increases muscle mass Reducing myostatin concentration in muscle appears to be a promising candidate for
treatment of diseases such as muscle wasting, obesity, or diabetes 1.
THUS, THERE HAS BEEN GREAT INTEREST IN MYOSTATIN AS A POTENTIAL MEDIATOR OF
SARCOPENIA AS WELL AS MODULATION OF MYOSTATIN AS A THERAPEUTIC TARGET. Suppressing
serum myostatin concentration through genetic disruption or congenital absence has been demonstrated to have many
potential health benefits besides increasing muscle mass, reducing age-related sarcopenia, and stimulating muscle
healing.2,3 Animal studies reported that lack of myostatin activity resulted in reduced weight gain4, fat cell size5, and
hyperglycemia, increased energy expenditure and improved leptin sensitivity6 as well as suppression of proatherogenic
dyslipidemia, and aortic atherogenesis.7
FORTETROPIN™ , IS A NUTRITIONAL SUPPLEMENT MANUFACTURED AND DISTRIBUTED
BY MYOS THERAPEUTICS. This food based product is a powder made from egg yolks and contains egg yolk
membranes and flavoring. FORTETROPIN™ appears to be an all-natural inhibitor of myostatin.
As the first step in developing this product, further documentation of the ability of this product to modulate serum
myostatin concentration has recently been completed. In 2005, Colker noted that standard store-bought fertilized
chicken eggs reduced serum myostatin concentration when administered to healthy young men.9 A method was then
developed to concentrate and sterilize the active fraction of egg yolks without inactivating the effect. Administration
of 10 grams of this extract, was administered in a clinical trial of 10 healthy men; however this study had no control
subjects.8 This study demonstrated a significant reduction in serum myostatin concentration at 12 hours postdose (12.6
pg/mL) compared to their baseline values (27.5 pg/mL) with concentrations back to baseline levels within 24 to 30 hours
postdose. Post hoc analysis of this data shows it to be statistically significant.
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OF NOTE, IT HAS BEEN ESTABLISHED THAT IN MEN, SERUM MYSOSTATIN CONCENTRATION
REMAINS STABLE OVER A 24 HOUR PERIOD, WITH NO DIURNAL VARIATION10.
RECENT STUDIES HAVE SHOWN THAT MYOSTATIN LEVELS ARE HIGHER IN OLDER THAN
YOUNG MEN AND THAT MYOSTATIN INCREASES IN MEN TREATED WITH GRADED DOSES OF
TESTOSTERONE, PERHAPS AS A COMPENSATING MECHANISM. However, myostatin levels were not
significantly associated with lean body mass in either young or older men attesting to the complex nature of muscle mass
regulation.11
A RECENT TRIAL CONFIRMED THAT FORTETROPIN™ REDUCES SERUM MYOSTATIN
CONCENTRATION. In this study conducted at a clinical research organization, serum myostatin concentration
measured in men at baseline and every 6 hours over the 24 hours following demonstrated a mean reduction of 30% (
data on file, Myos Therapeutics).
THE POTENTIAL OF THIS EGG YOLK EXTRACT TO MODULATE MYOSTATIN AND PERHAPS ASSIST
IN MUSCLE ACCRETION IN THOSE WITH REDUCED MUSCLE MASS IS OF OBVIOUS VALUE. It could
additionally add to muscle growth in those with normal muscle mass, and reduce the exercise effort required to maintain
muscle mass if its role as a myostatin inhibitor is confirmed.
References
•White TA, Lebrasseur NK. Myostatin and Sarcopenia: Opportunities and Challenges – A Mini-Review..Gerontology. 2014 Jan 17. [Epub ahead of print]
•Siriett V, Platt L, Salerno MS, Ling N, Kambadur R, Sharma M. Prolonged absence of myostatin reduces sarcopenia. J Cell Physiol. 2006 Dec; 209(3): 866-73.
•McCroskery S, Thomas M, Platt L, Hennebry A, Nishimura T, McLeay L, Sharma M, Kambadur R. Improved muscle healing through enhanced regeneration
and reduced fibrosis in myostatin-null mice. J Cell Sci. 2005 Aug 1;118(Pt 15):3531-41.
•Burgess K, Xu T, Brown R, Han B, Welle S. Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat
feeding in mice. PLoS One. 2011 Feb 24;6(2):e17090.
•Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K. Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents
hepatic steatosis. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E543-53. Epub 2011 Jan 4.
•Choi SJ, Yablonka-Reuveni Z, Kaiyala KJ, Ogimoto K, Schwartz MW, Wisse BE.Am J Physiol Endocrinol Increased energy expenditure and leptin sensitivity
account for low fat mass in myostatin-deficient mice. Metab. 2011 Jun;300(6):E1031-7. Epub 2011 Mar 22.
•Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic
dyslipidemia and atherogenic lesions in Ldlr null mice. 2009 Aug;58(8):1739-48. Epub 2009 Jun 9.
•Colker, C. Effect on serum myostatin levels of high grade handled fertile egg yolk AJCN 2009. 28:3, Abstract 29.
•Colker, C. Randomized blind comparison of follistatin in standard store-bought unfertilized chicken eggs versus standard store bought fertile eggs.
25: 5; Abstract 65; October 2006.
JACN,
•Vamvini MT, Aronis KN, Chamberland JP, Mantzoros CS. Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A
and follistatin but not myostatin in healthy males. J Clin Endocrinol Metab. 2011 Nov;96(11):3416-23. Epub 2011 Aug 24.
•Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER. Measurement of
myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. Mol Cell
Endocrinol. 2009 Apr 10;302(1):26-32. Epub 2009 Jan 21.
•White TA, Lebrasseur NK. Myostatin and Sarcopenia: Opportunities and Challenges – A Mini-Review..Gerontology. 2014 Jan 17. [Epub ahead of print]
•Siriett V, Platt L, Salerno MS, Ling N, Kambadur R, Sharma M. Prolonged absence of myostatin reduces sarcopenia. J Cell Physiol. 2006 Dec; 209(3): 866-73.
•McCroskery S, Thomas M, Platt L, Hennebry A, Nishimura T, McLeay L, Sharma M, Kambadur R. Improved muscle healing through enhanced regeneration
and reduced fibrosis in myostatin-null mice. J Cell Sci. 2005 Aug 1;118(Pt 15):3531-41.
•Burgess K, Xu T, Brown R, Han B, Welle S. Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat
feeding in mice. PLoS One. 2011 Feb 24;6(2):e17090.
•Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K. Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents
hepatic steatosis. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E543-53. Epub 2011 Jan 4.
•Choi SJ, Yablonka-Reuveni Z, Kaiyala KJ, Ogimoto K, Schwartz MW, Wisse BE.Am J Physiol Endocrinol Increased energy expenditure and leptin sensitivity
account for low fat mass in myostatin-deficient mice. Metab. 2011 Jun;300(6):E1031-7. Epub 2011 Mar 22.
•Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic
dyslipidemia and atherogenic lesions in Ldlr null mice. 2009 Aug;58(8):1739-48. Epub 2009 Jun 9.
•Colker, C. Effect on serum myostatin levels of high grade handled fertile egg yolk AJCN 2009. 28:3, Abstract 29.
•Colker, C. Randomized blind comparison of follistatin in standard store-bought unfertilized chicken eggs versus standard store bought fertile eggs.
25: 5; Abstract 65; October 2006.
JACN,
•Vamvini MT, Aronis KN, Chamberland JP, Mantzoros CS. Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A
and follistatin but not myostatin in healthy males. J Clin Endocrinol Metab. 2011 Nov;96(11):3416-23. Epub 2011 Aug 24.
•Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER. Measurement of
myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. Mol Cell
Endocrinol. 2009 Apr 10;302(1):26-32. Epub 2009 Jan 21.
Cenegenics Muscle Formula | Call 480.454.2370 to order!
11
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from Cenegenics® Medical Institute... The Global Leader in a proactive medical approach to optimized health
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