MYOPEP Info

For Evaluation Only.
Copyright (c) by VeryPDF.com Inc.
Edited by VeryPDF PDF Editor Version 4.1
Globally, Fat Facts
1 billion overweight adults
300 million obese adults
A major risk for chronic diseases:
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•
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Type 2 diabetes
Cardiovascular disease
Hypertension
Stroke
Cancer
Biomed Environ Sci 2002;15: 83–95
What is Myostatin?
•Cytokine - small signaling protein
•Produced in skeletal muscles
•Controls cell proliferation and
differentiation
•Restrains muscle growth
Cytokines - Intercellular Signals
• Coordinate the function of individual tissues
for the entire organism.
• Control tissue growth, development and
function.
• Molecular signals lead to a ultimate response
in or by the cell.
Three Muscle Systems
① Smooth Muscle
② Cardiac Muscle
③ Skeletal Muscle
Myostatin Blocks Myogenesis
Increases Adipogenesis
Myogenesis- the formation of muscle tissue
Adipogenesis- the formation of fat tissue
Clinical Study: Myostatin Inhibits Myogenesis and
Promotes Adipogenesis
“Myostatin promotes the differentiation of
multipotent mesenchymal cells into the
adipogenic lineage and inhibits myogenesis.”
Division of Endocrinology Metabolism and Molecular Medicine (J.N.A., S.B., S.R.-P., R.S., N.F.G.C.), RCMI DNA Molecular Core, Charles R. Drew University of Medicine and Science, Los Angeles,
California 90059
Myostatin promotes Fat Growth
Role of Myostatin in Slimming
• Myostatin negatively regulates muscle growth
and fat growth
• Inhibitors targeting myostatin are actively
being sought
• Therapeutics treatment of muscle-wasting,
cachexia, muscular dystrophy and sarcopenia
(Bradley et al, 2008; Tsuchida, 2008).
Myostatin blocking in Mice
In 1997, Se-Jin Lee
of Johns Hopkins
University School of
Medicine in
Baltimore, Maryland.
“The animals grew
muscles twice as big
as normal. “
Myostatin blocking
Muscle Dissection
Se-Jin Lee
Johns Hopkins University School of Medicine
“mice engineered to lack
myostatin exhibit dramatic
increases in skeletal muscle
mass throughout the body.”
“ If you could increase or
maintain muscle strength as
people age, you could have
a tremendous impact on
health and well-being.“
Myostatin
Blocked in Dogs
This bull has been bred to be predisposed
to Myostatin blocking
Double Muscled Sheep
Super Strong Kids May Hold Genetic Secrets
By LAUREN COX
ABC News Medical Unit
April 2, 2009
At 5 months old, Liam Hoekstra
of Grand Rapids, Mich. started
doing an expert move called the
iron cross. By 8 months he could
do a pull up.
Myostatin Inhibitor Peptide
Follistatin Isoform:
Follistatin blocks myostatin.
Research has shown that the blocking of
myostatin, by genetic elimination or by
increasing the amount of follistatin, results in
greatly decreased adipogenesis.
Clinical study: Changes in muscle myostatin expression
in obese subjects after weight loss
“myostatin-deficient
mice have a significant
reduction in fat
deposits and a
depression of
adipogenesis”
Journal of Clinical Endocrinol Metabolism. 2004
Jun;89(6):2724-7.
Increased muscle mass of senescent
(24-month-old) mice with Myostatin blocker (Myopep)
Toxicity of Myostatin Blocker
(Myopep)
Sub acute toxicity trials of Myopep daily in rats
(at 100 times recommended dose)
“showed no gross organ pathology
or negative behavioral effects”
Does Mysostatin deficiency effect the
heart muscles?
“no cardiac developmental abnormality has been reported in
myostatin-null mice “(1)
“There was no statistically significant difference between the
heart weight/body weight ratios of myostatin-null mice when
compared to wild-type mice” (2)
(1) McPherron AC, Lawler AM., S.J. L Regulation of skeletal muscle
mass in mice by a new TGF-beta superfamily member. Nature. 1997;387:83–90.
(2) Myostatin Does not Regulate Cardiac Hypertrophy or Fibrosis
Department of Neurology, Johns Hopkins University School of Medicine,
Baltimore, Maryland
Clinical Study: Organization of human myostatin gene
and expression in healthy men and HIV-infected men
with muscle wasting.
“concentrations of myostatin are increased in HIVinfected men with weight loss compared with healthy
men”
“ myostatin is an attenuator of skeletal muscle growth in
adult men and contributes to muscle wasting in HIVinfected men.”
of Endocrinology, Charles R. Drew University, Los Angeles, CA 90059; §Division of Endocrinology,
Washington University School of Medicine, St. Louis, MO 63110; ¶University of Toronto, Toronto, Ontario,
M5S1A1 Canada; and **Karolinska Institutet, Stockholm, SE-171 76 Sweden
*Division
Clinical study: Myostatin blocker reduces body fat,
fasting blood sugar, bad cholesterol and triglycerides
The mice with deleted myostatin gene:
•30% less body fat
• 80% lower fasting insulin levels.
•50 % lower low-density-lipoprotein ("bad") cholesterol
•30 to 60 percent lower levels of total cholesterol and triglycerides
*These results indicate protection against the development of
atherosclerosis.
Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH Jr, Kull FC Jr, Gonzalez-Cadavid N. Myostatin
inhibits cell proliferation and protein synthesis in C2C12 muscle cells.
Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Fareez MM, Gonzalez-Cadavid NF.
Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells.
Endocrinology.
Clinical Study: AAV-dependent targeting of myostatin
function: Follistatin strikes back at
muscular dystrophy
“A single injection of the myostatin inhibitor
proteins enhanced locally the muscle mass for
approximately 2 years.”
Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C et al. Long-term
enhancement of skeletal muscle mass and strength by single gene administration of
myostatin inhibitors. Proc Natl Acad Sci USA 2008; 105: 4318–4322.
In conclusion:
•Myopep induced muscle growth.
•The hypertrophic effect results from inhibition of
Myostatin
•The striking ability of Myopep to enhance muscle
growth warrants consideration as a regulator of
muscle mass
Myopep-Myostatin Peptide
Injectable Peptide:
Australian Manufactured
Accelerates Muscle Growth
Blocks the Enzyme that Limits
Muscle Growth
Self Limiting
No Side effects
Myostatin Deficiency
Myopep for Slimming
• Myopep Turns off the Creation of Fat
• Myopep Turns on the Building of Muscle
Myopep for weight loss:
One Subcutaneous injection a week
1ML for 10 weeks
Sharon lost 25 lbs. in 10 weeks
With no exercise or dietary changes
Myopep for Slimming
BEFORE
AFTER
Myopep for Slimming
BEFORE
AFTER
Myopep for Weight Loss
BEFORE
AFTER
Kathy has lost 25lbs in two months.
Her body fat is down from 36.4 to 29.7 as of 11th January 2012.
Her diet is the same as before.
She does 20 minutes of jump rope every other day and some light exercises.
She reports having more energy and being able to walk twice as far as before.
“One of the most promising ways of
increasing strength is by blocking a
protein called myostatin”
“Given all that biological evidence, a
drug that blocks myostatin would seem
like a slam dunk as a treatment for
muscular dystrophy”
Myostatin Drugs are possibly 4 times more
effective than high doses of steroids in growing
muscle
• The inoculations prevented muscle deterioration in
mice as old as 2 years -- 80 years in human terms
• The shots even regenerated muscle, restoring some
of the lost strength and size.
• Old mice regained 27 percent of muscle lost to age;
younger mice experienced a 15 percent increase
•
Body Building Testimonial
After 4 weeks on Myopep:
“My muscles are looking full and hard, maturity ever so evident. I can see
further fat loss.”
“I believe that more neuron pathways have been recruited my muscle
fibers are growing and repairing at an incredible rate.”
“No DOMS (Delayed onset muscle soreness) HAVE BEEN
EXPERIENCED THUS FAR post workout.”
BEFORE
AFTER
Myopep and Anti-aging
Sarcopenia- Degenerative loss of skeletal muscle mass and
strength with aging - .5-1% per year
Source: J Nutr Health Aging. 2008 Aug-Sep
Aging – Body Fat Increases/ Muscles Diminish
Cohn SH. New concepts of body composition. In: Ellis KJ, Yasumura S, Morgan WD (eds).
In Vivo Body Composition studies. The Institute of Physical Sciences in medicine: London, 1987, pp1-14.
Aging Gracefully
Veterinarian Applications
BEFORE
AFTER
Applications in
Veterinarian
Medicine
Treatment for Obese Pets
*Myopep will be officially launched in 2012. An oral supplement
form will be commercially available in May 2012*
For Evaluation Only.
Copyright (c) by VeryPDF.com Inc.
Edited by VeryPDF PDF Editor Version 4.1
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Laboratoires Dom AVMM (Suisse) Inc. has taken strict measures to safeguard the
reliability of the information contained herein. Neither Laboratoires Dom AVMM (Suisse)
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relation to the accuracy, reliability or completeness of the presented information.
All information contained in this presentation is intended for informational and
educational purposes. The information is not intended nor suited to be a substitute for
professional medical treatment or for professional medical advice.
We urge you to always seek the advice of your physician or medical professional with
respect to your medical condition or questions.
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