AnimalNEWS 11.2 - Morris Animal Foundation
Transcription
AnimalNEWS 11.2 - Morris Animal Foundation
v o lu me A H E A L T H I E R T O M O R R O W F O R A N I M A L S® IN THIS ISSUE Special Report: Human Health Advances Benefit Animals 11.2 11.2 IN THIS ISSUE 0 1 Finding common ground 10 Going to bat for bats 02 Taking a smart approach to brain cancer 11 Improving captive breeding in wild cats 04 Happy, healthy hearts 12 Your donations at work 06 New growth in stem cell research 14 In loving memory 07 Big clinic offers big benefits 16 Simple T-shirt leads to lifelong love 08 The power of a gentle touch 17 Create your own cause DEAR FRIEN DS, It seems that nearly every week we hear about a new medical breakthrough—not just OUR MISSION Morris Animal Foundation improves the health and well-being of companion animals and wildlife by funding humane health studies and disseminating information about these studies. for humans but for animals, too. The rapid pace at which medical advances are taking place is truly remarkable, and they couldn’t happen without scientific research that studies genetics and disease processes across many species. The news is full of stories about how discoveries in animals are improving human medicine—this issue of AnimalNews focuses on how technologies developed for use in people are being put to use to advance animal health. Foundation-funded studies taking place right now are evaluating the use of magnetic resonance imaging to diagnose canine brain tumors, the use of stem cells to treat spinal cord injuries and cancer and the use of human drug therapies that may help manage feline heart disease. And these are just a few examples—the advances in animal health over the next decade will likely be staggering. Also in this issue, we share the heartwarming story of Lovey, a cat rescued from an animal hoarder, who became a therapy cat after he participated in one of our Helping Shelters Help Cats studies. And we share information about some critical research being done to save bats—yes, the world needs bats!—and some of the world’s most majestic and endangered creatures—lions and tigers. As the days grow longer and warmer, we hope that you are warmed by the knowledge that, with your help, Morris Animal Foundation is doing its part to ensure longer, AnimalNews healthier lives for animals. Enjoy the summer! Volume 11 Issue 2 May 2011 AnimalNews is published four times a Warm wishes, year by Morris Animal Foundation. 10200 East Girard Avenue Suite B430 Denver, Colorado 80231 303.790.2345, 800.243.2345 www.MorrisAnimalFoundation.org Paul Raybould Executive Vice President Wayne Jensen, DVM, PhD, MBA Chief Scientific Officer P.S. Love of animals starts in childhood. Check out our new website for kids at www.MAFkids.org. Special Report: Human Health Advances Benefit Animals Finding common ground BY HEIDI JETER What two traits do Shar-Pei dogs and humans have in common? Wrinkles are an obvious characteristic. The second trait may be a genetic mutation that triggers autoinflammatory fever syndrome, a condition that affects this breed and humans. The March online issue of PLoS Genetics announced that researchers have determined that the gene mutation responsible for the wrinkled skin of Shar-Pei dogs is also linked to the fever disorder. For many years, health research was a one-way street focused on using animals as models for human health, but now information is going two ways. Recent completion of the genomes of humans, chimpanzees, dogs and many other species has hammered home just how interconnected we are. These genetic discoveries have led to greater emphasis on comparative medicine, the study of disease processes across species. The finding could help improve the health of both species, and it’s just one recent example of how medical advances and discoveries in one species can help another. That’s great news for animals, who have reaped the benefits of human medical technologies, such as chemotherapy, surgical techniques, X-rays and magnetic resonance imaging (MRI). Morris Animal Foundation has played a significant role in many of these advances. For example, the Foundation funded the first study of its kind to use abdominal MRI to distinguish between benign and malignant lesions in the liver and spleen of dogs. In that study, which ended a few years ago, researchers achieved a 90 percent diagnostic accuracy rate in using MRI. These results mirror those seen in humans. Today, Foundationfunded scientists are testing the technology’s ability to accurately diagnose brain lesions in dogs—and the results are promising. (Read more on page 2.) The concept of “One Medicine”—which emphasizes the overlap and interdependence between animal and human health—has been around for more than a century, but it wasn’t until recently that the world really took notice. In the area of stem cell research, the Foundation is funding studies that are evaluating the use of adult stem cells derived from the animal’s own fat or bone marrow to treat cancer and spinal injuries in dogs and musculoskeletal injuries in horses. (Read more on page 6.) When it comes to drug therapies, many of the drugs used to treat conditions like cancer, hyperthyroidism and heart disease in humans are now used regularly for treating dogs and cats. Researchers are currently studying whether four different drugs developed for humans are effective in treating feline heart disease and preventing associated blood clots. (Read more on page 4.) These are just a few examples of how human technologies are being used to improve the lives of animals. The more we learn from one another, the healthier we’ll all be. www.MorrisAnimalFoundation.org 1 Special Report: Human Health Advances Benefit Animals Taking a smart approach to brain cancer BY Kelle Y Weir novel tool may improve diagnosis and treatment of tumors When Dr. Annie Chen-Allen first saw Jade, an 11-year-old Pit Bull cross, the usually happy dog had been having seizures. The diagnosis was a lesion in her brain. The important question, though, was what kind? A lesion is any area of the brain that has been damaged due to infiltration of abnormal cells. It sounds simple, but treating brain lesions can be complicated because there are many types. Lesions can range from small to large, from few to many, or from relatively harmless to life threatening. In some cases, the lesion could be a brain tumor. These tumors are not uncommon in older Jade, whose brain tumor was dogs. Adult dogs of several successfully diagnosed. related short-nose breeds, such as Boxers, English Bulldogs and Boston Terriers, are often cited as having the highest incidence of brain tumors among domestic animals. A recent study indicated that Golden Retrievers also have a high incidence. Brain tumors vary widely in their level of malignancy. Some can be treated quite effectively—if the veterinarian can identify the exact type. getting a definitive diagnosis As with many diseases, a biopsy is the only definitive way to diagnose a tumor and determine what treatments are possible. Until recently, performing a biopsy required brain surgery, which has the potential to cause postoperative complications. Jade’s 2 owners had brought their dog to the right place, Washington State University, where Dr. Chen-Allen is working on a Morris Animal Foundation–funded study to evaluate a promising, less invasive brain-biopsy procedure for dogs. “In veterinary medicine, definitive brain tumor diagnosis is often made postmortem,” Dr. Chen-Allen says. “Although the advent of magnetic resonance imaging (MRI) has increased the sophistication for detection and characterization of lesions in the brain, tumor diagnosis is only presumptive with imaging.” She is testing an MRI-guided frameless stereotactic brainbiopsy system, a fairly new method that takes a sample the size of a grain of rice from a brain tumor using a neuronavigation system. The stereotactic system uses three-dimensional coordinates from a previous MRI to locate the tumor. Conventional stereotactic systems required a metal frame to be attached to a patient to acquire images, which can be complicated, but the frameless technique does not. This novel procedure shows potential to be superior to open brain biopsies because it allows a surgeon access to places a scalpel cannot reach and to access the brain without damaging surrounding tissue. The procedure is done in real time so that the clinician knows exactly where and how far to advance the needle. “A clinically applicable stereotactic brain-biopsy system that can improve brain lesion diagnosis is greatly needed in veterinary medicine,” Dr. Chen-Allen says. “A neuropathological diagnosis is critical for implementation of appropriate therapy.” moving on to treatment The options for treating brain tumors include radiation therapy, chemotherapy and palliative treatment. But brain tumors present unique problems related to their location and the tissues they affect. Dr. Chen-Allen’s study shows that frameless stereotactic biopsy of lesions is a valuable and safe tool for diagnosing brain lesions, regardless of lesion location. Special Report: Human Health Advances Benefit Animals Potential risks of this type of biopsy, like bleeding at the area of surgery, are the same as those reported with the conventional biopsy technique. Patients are usually kept in intensive care for 24 hours after the procedure, allowing clinicians to administer supportive care, monitor vital signs and detect any signs of neurologic deterioration. Patients are usually discharged 48 to 72 hours after the biopsy. “The clients that have enrolled in this study have all been very thankful to the Foundation for providing the financial support for this clinical trial,” Dr. Chen-Allen says. “Although there are always risks associated with procedures like these, owners are comforted knowing that they are able to provide their pets with the most advanced medicine available.” So far, five dogs have successfully undergone the advanced biopsy technique and follow-up treatment. Within days of Jade’s biopsy, Dr. Chen-Allen and her team knew the type of tumor she had and, knowing that Jade’s type of tumor responds well to radiation therapy, the team prescribed 18 treatments. Luckily, Jade responded well and was able to add precious months to her life at home with her family. Signs of brain disease • Seizures • Circling • Headtilting • Leaningorfalling Tucker was diagnosed with a brain mass in the right piriform and is undergoing treatment. • Lackofcoordination • Paralysis • Eyeoscillations • Blindness • Unsteadinessorstaggering • Forgettingcommands • Failuretorecognizefamiliarpeople familiar people • Unexplainedaggressivenessor aggressiveness or puppy-likebehavior Roy is being treated for a brain mass in the right olfactory and frontal lobe. www.MorrisAnimalFoundation.org Ifyourpetexperiencesanyofthesesymptoms, seeyourveterinarianimmediately. 3 Special Report: Human Health Advances Benefit Animals Happy, healthy hearts BY AmY ETTINgER human medical advances help felines Heart disease can strike cats in the prime of life—usually between the ages of 5 and 8 years. Cats with heart disease may not show any symptoms until it’s too late for treatment. They can also quickly experience devastating complications, such as heart failure and life-threatening blood clots. With Morris Animal Foundation funding, scientists at four universities are studying whether drugs developed for humans can be beneficial for treating feline heart disease and preventing associated blood clots. evaluating outcomes Researchers at North Carolina State University College of Veterinary Medicine are evaluating whether beta-blockers can help cats with hypertrophic cardiomyopathy (HCM), the most common type of feline heart disease. Beta-blockers are prescribed in people to block the effects of adrenaline on the heart, making the heart beat slower and improving oxygenation. Researchers hope to see a similar response in cats, says Dr. Teresa DeFrancesco, a researcher at North Carolina State. Health warning signs The warning signs of heart failure or life-threatening blood clots include • Lossofappetite • Lethargy • Vomiting 4 Every day, Dr. DeFrancesco sees at least one cat with HCM in her clinical practice. Current treatment of HCM usually includes beta-blockers and calcium-channel blockers, but their effectiveness isn’t really known. “We don’t know if anything we do for these cats will change the outcome in the preclinical stage of the disease,” Dr. DeFrancesco says. During the six-month study, 30 cats will be given either a betablocker or a placebo. Scientists will measure the activity levels of the cats using an accelerometer attached to a collar. Blood tests will measure cardiac biomarkers to assess ischemic injury to the heart and strain on the heart muscle. Finally, veterinarians will perform echocardiograms to see how the heart is filling with blood during the diastolic phase of the cardiac cycle. Dr. DeFrancesco says she’s grateful for the Foundation funding, which has allowed her to pursue this important research. “Morris Animal Foundation is a non-biased, independent way of funding these studies,” she says. “The Foundation purely has the interest of the animal in mind.” increasing survival rates Researchers at Kansas State University recently completed a Foundation-funded study looking at how the drug pimobendan behaves in healthy cats. The drug has been used for more than 15 years in Europe and more than 3 years in the United States to increase life expectancy and quality of life of dogs with heart failure. Researchers hope the drug can help cats, too. In this study, researchers measured how quickly healthy cats absorbed the drug and the rate at which it was eliminated. This is the first step in determining if the drug could help cats—and the results were promising. “Essentially it was very similar to how the drug behaves in dogs,” says Dr. Michele Borgarelli. Special Report: Human Health Advances Benefit Animals preventing blood clots than aspirin. Dr. Hogan has already completed one Foundation-funded study, and he received additional funding to enroll 70 more cats into the clinical trial. So far, researchers have seen a 30 percent reduction in recurrence of blood clots between groups, but to eliminate any bias, Dr. Hogan won’t know which cat received which drug until the study is over. At the University of Illinois, researchers are studying a different approach to preventing feline blood clots. Current anticlotting pills are costly and are difficult for pet owners to administer, says Dr. Stephanie Smith. So, Dr. Smith and her team are looking at an injectable drug, idraparinux, which is an anticoagulant given just once a week in people. Dr. Smith is studying the effect of the drug in eight healthy cats to determine the best dosage. Idraparinux also has a reversal agent, which can be given if the cat needs to undergo surgery, and Dr. Smith will study the dosage of that as well. Dr. Borgarelli and his team concluded that the optimal dosage for the drug is the same for cats as it is for dogs. They reported no side effects of pimobendan in the studied cats. Dr. Borgarelli says the next step is to look at the effects of the drug in cats with heart failure and determine if it improves their survival and quality of life. “Maybe the survival rate with treatment will be as good or better in cats than it is in dogs,” he says. She says there are plenty of drugs on the market to prevent feline blood clots, but it’s difficult to know which ones are most effective. “Blood clots are fatal more often than we would like, but less often than they used to be,” says Dr. Smith. Those medical improvements are due, in part, to previous studies funded by Morris Animal Foundation. We hope these current studies can save even more feline lives. preventing fatal blood clots Blood clots are a common complication of feline heart disease, and cats frequently die or are euthanized because of blood clots that often occur in the rear legs. Two studies are looking at drugs that could prevent the condition in cats. At Purdue University, Dr. Daniel Hogan is looking at whether the drug commonly known as Plavix is more successful at www.MorrisAnimalFoundation.org Join us We now have a Facebook page just for cat lovers. Join us at www.facebook.com/HappyHealthyCat. 5 Special Report: Human Health Advances Benefit Animals New growth in stem cell research BY KEllE Y WEIR Stem cell research has blown the door of science wide open for new therapies to address diseases that animals face. Currently, adult stem cells are being investigated as treatments for a variety of conditions that affect dogs, including cancer and spinal cord injuries. Adult stem cells—also called somatic stem cells—can be derived from the dog’s own fat tissue and marrow. “Adult stem cells are highly applicable to many diseases, and their significance lies in how they can somehow find a site of injury in need of repair, create an environment that is conducive to repair or even become cells that are incorporated in the repair itself,” says Dr. Jorge Piedrahita, a leading stem cell researcher at North Carolina State University’s College of Veterinary Medicine. Additional research is needed to determine the full potential of stem cell treatments. Funding the necessary studies is where Morris Animal Foundation shines. determining the effectiveness on spinal cord injuries Spinal cord injuries are a common problem in dogs. About 20 percent of these injured dogs suffer from incontinence and lose all motor and sensory function to the hind legs. For most, the damage is permanent. One Foundation-funded study is evaluating adult stem cells taken from fatty tissue in a patient’s shoulder or abdomen. These cells have the powerful ability to reduce inflammation and differentiate into diverse specialized cell types. Dr. Natasha Olby, from North Carolina State University, hopes these cells can help treat dogs that suffer from severe spinal injuries. Numerous studies have shown that transplantation of a variety of stem cell types into an injured spinal cord is safe and effective. Cells can be successfully transplanted into the canine spinal cord via a needle instead of “open” surgery, which was used in the past. This approach is much less invasive, but more research is needed to establish this type of stem cell therapy as traditional practice in veterinary offices. 6 “With the recent explosion of stem cell therapy, poorly controlled studies are resulting in contradictory results, making it unclear whether transplantation is effective,” Dr. Olby says. She also points out that there is an alarming lack of scientific support for different therapies that are requested by owners and a real need for more careful assessment of the value of stem cells taken from the patient. Controlled studies, like the one Dr. Olby is conducting, will help determine the effectiveness of this technique. tackling cancer with stem cells Cancer therapy doesn’t always lead to long-term remission. A major reason for failure of conventional treatments may be their inability to eradicate cancer stem cells. These cells are selfrenewing, can spread to new areas of the body and can produce rapidly dividing daughter cells. This means that leaving behind even one cancer stem cell after treatment can cause the cancer to return. Dr. Alex Davies, from the University of California–Davis, is identifying early changes in the stem cell niche that contribute to tumorigenesis and the generation of cancer stem cells. When the research is completed, it will provide important insights supporting the design of future therapeutic strategies to block cancer progression. At the University of Minnesota, Aric Frantz, a former Morris Animal Foundation veterinary student scholar, hopes to develop more effective therapeutic strategies that target cancer stem cells and cause fewer side effects for dogs with cancer. “If we can successfully identify and target these cells, owners may be able to keep their companions at their side much longer,” Frantz says. “Even after a diagnosis of cancer.” More research on stem cells Learnmoreaboutresearchintotheuseofstem cells for horses at www.MorrisAnimalFoundation.org/windybill. Big clinic offers big benefits BY AlEx JImENEz veterinarians excel at personal touch and charitable giving A quick visit to North Portland Veterinary Hospital (NPVH) shows all the signs of a happy, healthy veterinary practice. It’s warm and welcoming, full of engaging doctors and staff and offers a full range of small animal services from surgery to dental work, general treatment and more. This large practice, owned and managed by Dr. Don McCoy, isn’t just your typical animal clinic though. With 10 doctors with degrees from nine different veterinary schools, including Purdue University, Colorado State University, Texas A&M University and Liverpool University, NPVH stands among the few practices that are able to mesh a team of veterinarians with such varying backgrounds and still maintain a personal and professional feel. “The program really helps create a genuine bond with our clients during a tough time,” Dr. McCoy adds. Dr. McCoy has been a long-time supporter of Morris Animal Foundation even beyond the memorial card program. He is a big fan of the Foundation’s founder and namesake, Dr. Mark L. Morris Sr., and he often shares the Foundation’s inspirational beginning with colleagues and associates. The Foundation is proud to have Dr. McCoy and his diverse team as partners and friends in helping to create a healthier tomorrow for animals. “We are one great big family,” says office manager Sherri Penner, who has been with the hospital for more than 20 years. “We get along amazingly well for a staff of over 45 people. It is a testament to Don and Melinda McCoy [office bookkeeper] and how the business is run.” Dr. McCoy points out that the benefits of having such a cooperative and diverse staff are seen in the exam room as well. “Each doctor brings their own individual strengths to the team, but together we all contribute to the same goal—creating the best possible experience for both the owner and pet,” says Dr. McCoy. Recently, Dr. McCoy and his practice were honored for ongoing support of Morris Animal Foundation (photo at right). NPVH was the top clinic user of the Foundation’s Veterinary Memorial Card Program in 2010. The memorial card program allows veterinarians to make a donation in honor of a recently deceased pet, and the Foundation sends a customized card to the pet’s family notifying them of the memorial gift. The donation funds research that could potentially find a cure for the very same disease that took the animal’s life. Dr. McCoy believes the card program helps his clinic build the kind of personal client relationships that have made the practice a success. www.MorrisAnimalFoundation.org Honor your vet This year marks the 250th anniversary of veterinary medicine. As part of World VeterinaryYear,youcanrecognizeyour veterinarian’s outstanding care and commitment by sending an Honor Card or addinghimorhertoourVeterinaryHonor Roll.Visitthe“SupportAnimalHealth” section at www.MorrisAnimalFoundation.org andclickon“Honor a Veterinarian.” 7 The power of a gentle touch BY HEIDI JETER Lovey is a beautiful white cat who lives with his little cousin Pepsi in a wonderful home where he helps his owners care for foster kitties. He’s earned the nickname “therapy cat” because he is able to befriend any animal who enters his home. And this remarkable cat is so attuned to his human family that when their daughter was bedridden from a bad cold, Lovey stayed by her side giving her comfort and love. His life sounds picture perfect, but Lovey likely wouldn’t be alive today if it hadn’t been for a unique Morris Animal Foundation study led by researchers at the University of Queensland in Australia. Lovey was rescued from an animal hoarder, in a house where most of the 50 cats were living in holes in the walls. Lovey had mites, fleas and internal parasites. He was missing patches of fur, was very dirty and had overgrown claws. He was so terrified of humans that he wouldn’t let himself be touched. Fortunately, after receiving medical attention, Lovey entered one of the Foundation’s Helping Shelters Help Cats studies, where he was soon under the care of Nadine Gourkow, a PhD candidate at the University of Queensland. Gourkow says that although she has worked as a shelter professional for more than 12 years, she would not have believed that cats like Lovey could be rehabilitated, but as part of the Foundation–funded study team, Gourkow has discovered a lot about the resiliency of cats when handled with love. handled with care Under the mentorship of Dr. Clive Phillips, Gourkow is evaluating the effectiveness of a process called “gentling,” which involves touching the cat in a way that resembles grooming by other cats. Cats receive short sessions that include petting and massage several times per day. Gourkow pets the cats on the head and under the chin using a circular motion. The key is to pay close attention to the cat’s response and pull away as soon as it seems agitated. Petting and food gifts are always given together. 8 When he first entered the shelter, Lovey spent most of his days hiding under his bedding and would eat only when food was placed under his blanket. He would only let himself be stroked through the blanket, and even then he would flatten his body and try to crawl away. Eventually, Lovey let Gourkow touch him on the forehead and behind the ears, though still only through the blanket. After a few days of gentling, Lovey began to relax, and Gourkow could pet his body directly. Near the end of the study, he would crawl toward the front of the cage, though still under his blanket, and he would start purring and kneading when Gourkow talked to him. “Every day was a miracle with this cat,” she says. Photo courtesy of Nadine Gourkow one cat’s journey from a hoarder’s house to a loving home Give shelter cats a second chance Donate to Helping Shelters Help Cats today and every dollar donated, up to $500,000, will be matched by an anonymous donor. We need to raise $140,000 by June 30 to qualify for the final year of dollar-for-dollar matching funds. Visitwww.Research4Cats.org today to have your donation doubled. a healed soul becomes a healer When Lovey was ready for adoption, he was transferred to a communal area with some of his brother and sisters from the hoarder’s house. The care team then learned that Lovey had a special talent. He very quickly gravitated toward Theo, an aggressive and fearful cat who had been at the shelter for several months. Lovey jumped on Theo’s perch, cuddled in close and licked the terrified cat’s forehead. In less than a week, Theo was a transformed cat and was able to be adopted. “We could put Lovey with any cat who was terrified, and he would take care of them,” Gourkow says. “He has a beautiful soul and he’s just a helper.” Lovey later went to live in a foster home, where his caretakers quickly saw how his unique gift to calm other cats could help other foster cats in their care. They decided to adopt him so that he could continue working to help other cats become more adoptable. Before gentling, Lovey huddled terrified under his blanket. Lovey is just one of the cats that have gone through the study that would have been deemed unadoptable and likely euthanized under usual shelter conditions. Gourkow plans to use the results from this study to develop practical training manuals and videos for shelter personnel. These educational materials will help shelter personnel identify the types of emotional states of cats in shelters so that they can take the right approach to rehabilitate them—and get them into happy, loving homes. Photos courtesy of Nadine Gourkow “Had it not been for the gentling, Lovey might not have survived the trauma of sheltering,” Gourkow says. “I feel privileged to have been part of his life and to have been there for him when he needed a little human therapy.” Lovey quickly befriended Theo. Learn more Watch video of Lovey’s transformation at www.Research4Cats.org. www.MorrisAnimalFoundation.org 9 Going to bat for bats B Y K AT E J o R D A N researchers rush to battle rapidly spreading epidemic Though viewed as symbols of good health and fortune in many parts of the world, bats have often been maligned in Western culture as evil, bloodthirsty creatures. In truth, bats play a crucial role in our ecosystem. Capable of devouring thousands of insects in a single night, bats are a tremendous asset in helping to maintain healthy crops, such as cotton and corn. They also serve important aesthetic and economic functions by pollinating countless flowers and vegetables. Bats’ significant contributions are starting to be recognized. Over the past two years, about one million bats in North America have died of a disease called white-nose syndrome. Some species, including North America’s most common bat, the little brown myotis, are likely to become regionally extinct within 16 years. team is also researching whether there is a genetic basis for the small percentage of bats that appear to be resistant to the fungus. By simultaneously studying the bat population’s genetic structure and variations in the fungus found in different regions, Dr. Kunz and his team may be able to identify populations that can still be saved. “At this point we are doing damage control,” Dr. Kunz says. “But the fact that the Foundation has backed this research so far has been vital.” Morris Animal Foundation is honored to provide funding to Dr. Kunz, one of the preeminent bat scholars in the world, in the race to save as many bats as possible. “We’re facing the biggest wildlife crisis in history,” says Dr. Thomas H. Kunz, a professor of biology and director of the Center for Ecology & Conservation Biology at Boston University. “There have been times during this epidemic when we couldn’t even walk inside certain caves due to the piles of dead bats.” With Morris Animal Foundation funding, Dr. Kunz and his students and colleagues are tackling the disease with a focus on molecular genetics. By studying the genetics of the little brown myotis—the species most likely responsible for the disease’s prevalence and spread—his team hopes to determine the dispersal patterns of this widespread species. From this information, they hope to be able to predict the spread of whitenose syndrome and protect bat colonies not yet affected. His 10 Photo Credit: Alan C. Hicks The disease, caused by a fungus, appears to spread from bat to bat, and it is also spread by human cave visitors who inadvertently move the fungus to different caves. The fungus invades the skin on a bat’s ears, nose, tail and wings—ultimately causing severe body-fat loss and fatal dehydration. This hibernating little brown myotis has white-nose syndrome (see the white spot on its nose). The fungus is rampantly killing off entire bat populations. Improving captive breeding in wild cats BY AlEx JImENEz Today, it is estimated that there are fewer than 10,000 cheetahs, 7,000 tigers and 5,000 snow leopards left in the wild. These are just a few of the world’s wild cats whose populations have dwindled to critically endangered levels in recent decades. Shrinking numbers are largely due to the combination of poaching and habitat destruction. Conservation scientists and activists are aggressively addressing both problems, but sadly, it’s becoming more evident that ending poaching and habitat destruction won’t be enough to ensure a stable future for many of these big cats. That’s where Dr. Alexander Travis’s research at Cornell University may play a pivotal role in feline conservation. In a study funded by Morris Animal Foundation, he explored ways to more effectively preserve the genetic diversity of the remaining cat populations. “This is especially important in the management of small populations, such as endangered species or those in captive conditions,” explains Dr. Travis. The process has been slower with cat tissue than with tissue from other species. In comparison, Dr. Travis says their ferret xenografts produce much more sperm than those from cats. Dr. Travis focused the initial part of his research on defining the age range for which xenografting would be effective. He found that the procedure works for tissue from neonatal donors up through donors at the start of puberty. After successful completion of the Foundation-funded study, Dr. Travis is continuing this important work by assessing whether the sperm produced from xenografting have the ability to fertilize an egg. Results from these studies have been so promising that Dr. Travis is encouraging zoo veterinarians and conservationists to begin banking testicular tissue from deceased prepubertal animals that could one day advance captive-breeding efforts. Most attempts to preserve genetic diversity have focused on freezing sperm. However, sperm cannot be collected from animals until they reach reproductive maturity, and neonatal and juvenile mortality affects a number of endangered species. For captive breeding, this poses a massive problem. If a genetically valuable male dies before puberty, his genes are forever lost from the population. Dr. Travis’s research is primarily based on a technique called testis xenografting—a means of producing sperm from testis tissue collected from juvenile animals just after death. Xenografting takes advantage of the fact that although these young animals do not possess sperm, they do possess the stem cells that would one day produce sperm. By freezing the testis tissue, it can be stored so that sperm can be produced through xenografting at a later time when that animal’s genes are needed for breeding. www.MorrisAnimalFoundation.org A unique reproductive technique could help save endangered cats, like the beautiful snow leopard. 11 Your donations at work Your donations truly make a difference in the lives of animals worldwide. At any given time, Morris Animal Foundation manages about 300 active studies and about 70 veterinary student scholar projects. Here’s a look at some recent successes made possible through your support. evaluating osteoarthritis drug treatments Dr. Eric Troncy University of Montreal for cats therapy reduces incidence of urinary stones Dr. Jody Lulich University of Minnesota Urinary stones cause painful, bloody urination and are a common problem in cats. About 5 percent of these stones are made of urate, a salt of uric acid. Urate stones represent the third most common stones that form in the urinary tract of cats. Understanding what causes urate stones to form is essential to developing effective therapies to manage the disease and prevent recurrence. Researchers from the University of Minnesota hypothesized that cats that form urate stones have higher concentrations of uric acid in their blood and urine compared with healthy cats. The researchers confirmed that an increased concentration of uric acid is a risk factor for urate stone formation. Osteoarthritis is a common and painful joint disease in cats. However, no medication is currently approved to help alleviate the painful clinical symptoms of this disease in felines. To assess pain treatment, it is important to know how and where the pain occurs. Dr. Eric Troncy and his team used quantitative gait analysis to determine how osteoarthritis affects the animal’s function levels and magnetic resonance imaging to assess structural changes in the cat. By determining how osteoarthritis affects joint and articular movement, researchers were able to develop a platform to validate the nature of disease-induced alterations in cats and evaluate the efficacy of drugs or nutraceuticals for alleviating limb impairment. The end goal is to use this evaluative information to improve quality of life for arthritic cats. This finding confirms that dietary and medicinal therapy to lower uric acid levels will reduce the incidence of this painful condition in cats. for dogs study identifies causes of brain inflammation Dr. Scott Schatzberg University of Georgia Meningoencephalitis, a general term for inflammation of the brain and its outer covering, is a naturally occurring disease in dogs that is believed to be caused by genetic and environmental factors. The disease has a grave prognosis when the cause is unknown, and unfortunately, the cause is unclear in 75 percent of cases in dogs. In humans with meningoencephalitis, a polymerase chain reaction (PCR) test is used to definitively diagnose causes of infection, and as a result, survival rates have improved. Researchers from the University of Georgia used PCR to identify suspect microorganisms in canine meningoencephalitis. They identified two viruses that are not typically considered to be pathogens in dogs, La Crosse virus and Merkel cell carcinoma virus, and determined that La Crosse virus may be associated with specific forms of canine meningoencephalitis. In addition, two bacteria (Mycoplasma spp. and Bartonella) were also identified. This knowledge should result in better diagnoses and allow for specific therapeutic intervention, thereby improving survival rates for affected dogs. You can help Every gift you make, no matter how large or small, helps Morris Animal Foundation create a healthier tomorrow for animals. Simply return your gift in the enclosed envelope or visit www.MorrisAnimalFoundation.org. The animals will thank you. 12 © Greg Neise LPZ overcoming chemotherapy resistance Dr. Steven Suter North Carolina State University Canine lymphoma is one of the most common tumors in dogs. Though dogs initially respond well to treatment, the disease has a dismal overall cure rate of less than 10 percent. The lymphoma usually develops chemotherapy resistance and spreads, which is why most dogs eventually succumb to the disease. Scientists at North Carolina State University determined that the area of DNA that is responsible for turning on and turning off gene expression is significantly altered in cancer patients. The affected genes, depending on their role in the cell, can lead to cancer progression if they are not regulated properly. These data provide compelling evidence that chemotherapy resistance may be overcome by using specific drugs that reverse resistance. The results of further research could benefit both human and companion animal patients with lymphoma. for horses insight into vaccine development Dr. Steeve Giguere University of Georgia Pneumonia is the leading cause of illness and death in foals in the United States. The bacteria Rhodococcus equi causes most cases of pneumonia. Because R. equi is highly prevalent, most foals are exposed to the bacteria very early in life. Giving them a vaccine before they are a week old could save lives, but very little is known about the ability of a newborn foal’s immune system to respond to vaccines in general. New data indicate that newborn foals have poor immune responses to vaccination compared with adult horses. Researchers at the University of Georgia determined that although a newborn foal’s immune system is somewhat functional, its immune responses are much lower than that of older foals or adult horses after vaccination with a killed vaccine, the type of vaccine most commonly used for horses. This information can be used to develop vaccines that will stimulate the appropriate type of immune response in newborn foals. for wildlife monitoring stress in injured owls Dr. Patrick Redig University of Minnesota Fecal hormone monitoring is a noninvasive tool used to monitor stress responses in many species of wild and captive animals, but this tool hasn’t been used to assess stress in injured wildlife undergoing rehabilitation. Rehabilitation of raptors sometimes involves stressful procedures, yet it is difficult to quantify how stress levels affect rehabilitation outcomes in these animals. Researchers at the University of Minnesota used fecal hormone analysis to assess stress hormone levels and responses in injured great horned owls as they went through the stages of rehabilitation. Stay up to date Get more health breakthroughs supported by Morris Animal Foundation. Sign up for eNews at www.MorrisAnimalFoundation.org. www.MorrisAnimalFoundation.org The findings provide a way to clearly quantify the stress response of an individual animal at any given time and could help rehabilitators intervene to reduce stress. All of the birds in the study were successfully rehabilitated and released back into the wild. This study contributes to the understanding of the dynamics of stress responses and how animals adapt to captivity, thereby improving the management, health care and health outcomes of injured raptors throughout the rehabilitation process. better to breed wild cats at young age Dr. Suzanne Kennedy-Stoskopf and Charlotte Farin North Carolina State University At about 7 or 8 years old, many wild female cats experience reproductive senescence, or the inability to conceive or maintain viable pregnancies. Older females often fail to become pregnant with natural breeding or assisted reproductive techniques, even though they are still considered in prime health and have half their life expectancy remaining. This phenomenon has major implications for species survival plans that manage captive populations. Understanding the basic biology of how aging affects female reproductive potential will help in managing small populations of felids. Using the Pallas’s cat as a model, investigators examined several potential factors that may be contributing to senescence. The researchers discovered that older Pallas’s cats produce as many oocytes, or immature eggs, as younger cats, but the fertilized oocytes of older cats fail to develop into competently dividing embryos. These findings suggest that the age of a female wild cat is a factor, and breeding should occur by 2 to 3 years of age. Researchers also said it is important to pair young animals rather than waiting to determine whether older animals that have never bred will succeed. 13 In loving memory At Morris Animal Foundation we know how difficult it is to lose a special pet. Pets are part of our families, and this section honors the amazing animals that have touched their families’ lives. The pets in this section were honored through qualifying donations made between December 16, 2010, and March 15, 2011. These gifts will be used to improve animal health by funding research that can help protect, treat and cure the animals of the future. 14 Gifts of $200 or more per pet qualify a special pet to be listed in the “In loving memory” section of AnimalNews. Please send a photo for consideration with your donation. For donations of $500 or more, a brass plate engraved with your pet’s name will also be added to our Pet Memorial Wall. For more information, please contact us at 800.243.2345 or [email protected]. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Andrew Chloe Magic Rusty White Feathers LB (28) Beloved Cat D O N OR : Phyllis Levine FA M ILY : The Levine Family Beloved Dog DONOR : Richard Rudman & Karen Greenberg FAM I LY : Stephanie Spooner Beloved Arabian Mare DONOR: Chuck & Linda Weir FAMILY : Chuck & Linda Weir Beloved Friend & Dog DONOR: Edward & Marjorie McDowell FAMILY : Edward & Marjorie McDowell Archie Beloved Pet D O N OR : Susan Engelhardt Irwin FA M ILY : Donna Toole Cole (11) Beloved Dog D O N OR : Maury Wollff FA M ILY : Elizabeth Evans Haynie Corrie Beloved Chihuahua D O N OR : Friends of Bella Sophia FA M ILY : Anonymous Cosette (12) Auggie Bella Sophia (1) Ben Beloved Dog D O N OR : Gordon & Edith Harper FA M ILY : Gordon & Edith Harper Benji (2) Beloved Dog D O N OR : Colleen Haggerty FA M ILY : Colleen Haggerty BILBO (3) Constant Companion, Guide, Humorist & Shoulder D O N OR : Friends of BILBO & the BILBO BASH FA M ILY : Marcelle LeCompte & Rick Friedman Brandy (4) Beloved Friend & Companion D O N OR : Joel Pritkin FA M ILY : The Sener Family Bronwyn (5) Beloved Dog D O N OR : Elizabeth Delfosse FA M ILY : Elizabeth & Erik Delfosse Buster (6) Beloved Labrador Retriever D O N OR : Mark Steele FA M ILY : The Steele Family Candi & Heather Beloved Flat-coated Retriever DONOR : Jack Faul & Debbie Davis FAM I LY : Jack Faul & Debbie Davis Beloved Companion DONOR : Janis Koch FAM I LY : Janis Koch Beloved Pet DONOR : Richard & Margrit Lichter Foundation FAM I LY : Richard & Margrit Lichter Cutter Beloved Pet DONOR : Colleen Henling FAM I LY : Richard & Alice Reese Daphney Beloved Greyhound DONOR : Rolf & Sharon Tandberg FAM I LY : Rolf & Sharon Tandberg Daqx (13) Beloved Companion for 16 Years DONOR : Bob & Barbara Loer FAM I LY : Bob & Barbara Loer Echo (14) Beloved Brown-eyed Girl DONOR : Dr. A. C. & Margaret Lee FAM I LY : Angela Lawrence Gracie (15) Beloved Companion DONOR : Edward Hammond FAM I LY : Gregory Parr & Edward Hammond Gracie Beloved Pet DONOR : Hunt Valley Animal Hospital FAM I LY : The Greenberg Family Beloved Pets D O N OR : Carol S. Martin FA M ILY : Carol S. Martin Hershey Flanagan Beloved Dog D O N OR : Fred & Judy Goosen FA M ILY : Fred & Judy Goosen Hogan (16) Cane Cassidy (7) Beloved Dog D O N OR : Stephanie & Mike Perry FA M ILY : Stephanie & Mike Perry Ceci (8) Beloved Bouvier D O N OR : Nick & Carol Buonato FA M ILY : Nick & Carol Buonato Cedric (9) Beloved Pet D O N OR : Richard & Kathryn Marshburn FA M ILY : Richard & Kathryn Marshburn Chipper (10) Beloved Dog D O N OR : David & Ryne Badgley FA M ILY : Ryne, David & Jennifer Badgley Beloved Dog DONOR : John Flanagan FAM I LY : Catherine Huang Beloved Pet DONOR : Daniel Webster Animal Hospital FAM I LY : Frederick & Patricia Gibbs Julian Beloved Cat DONOR : Kristen Smith FAM I LY : Laurie A. Smith King Kaput (17) Beloved Cat DONOR : Nancy Hallam FAM I LY : Carolyn Hallam Lacey Beloved Pet DONOR : Earl & Sheran Flippo FAM I LY : Jeff & Rose Flippo Lila & Harmony Beloved Pets DONOR : Diane & Owen Lynch FAM I LY : Diane & Owen Lynch Logan (18) Beloved Dog DONOR : Shari Sarris FAM I LY : George Sarris www.MorrisAnimalFoundation.org Major Beloved Pet DONOR: Heather Lilly FAMILY : Stephanie Foster Marley (19) Beloved Golden Retriever DONOR: Cindy Affolder FAMILY : The Gooch/Williams Family Max Beloved Australian Shepherd Mix DONOR: Chuck & Linda Weir FAMILY : Chuck & Linda Weir Minnie & Mickey Beloved Pets DONOR: Phyllis Levine FAMILY : The Levine Family Morgan Beloved Cat DONOR: Suzanne Underwood FAMILY : Candace Carlson Mouse (20) Beloved Cat DONOR: Nancy Hallam FAMILY : Nancy Hallam Mozart (21) & Gismo (22) Beloved Cats DONOR: Bob & Mary Schwartz FAMILY : Bob & Mary Schwartz Natasha (23) Beloved Fluffy Girl DONOR: Joann & Michelle Kazdin FAMILY : Nicole Kazdin Patch (24) Beloved Companion DONOR: Edward Hammond FAMILY : Gregory Parr & Edward Hammond Phoenix (25) Beloved Dear Heart DONOR: Jo Elizabeth MacNair FAMILY : Jo Elizabeth MacNair & Ann L. Dupuis Pippin Beloved Pet DONOR: Susan Engelhardt Irwin FAMILY : Nancy Hartman Pivot Beloved Pet DONOR: Ann & Peter Anderson FAMILY : David & Karen MacMillan Remington (26) Beloved Samoyed DONOR: Dr. A. C. & Margaret Lee FAMILY : Marsha Carfield Remington Beloved Pet DONOR: Henry Roath FAMILY : Michael & Michelle Simms Robbie’s Fritzie, Robbie’s Penelope Katrina & Penny K. Wahl Beloved Pets DONOR: Barbara J. Wahl FAMILY : Barbara J. Wahl Roxy (27) Beloved Friend of 17+ Years DONOR: Scott DeBruhl FAMILY : Scott & Lynda DeBruhl Samson Beloved Cat DONOR: John & Billie Harwood FAMILY : John & Billie Harwood Sandy Beloved German Shorthair DONOR: David & Erlene Price FAMILY : David & Erlene Price Sara (29) Beloved Pet DONOR: The James P. Sullivan Jr. Charitable Trust FAMILY : Margaret T. Sullivan Sinckers, Murphy & Charlie Beloved Pets DONOR: Linda McBain & George Waters FAMILY : Linda McBain & George Waters Snoopy Beloved Dog DONOR: Colleen Henling FAMILY : Gail & Bert Gavin Sugar Beloved Pet DONOR: Kim Harris & Scott Weiner FAMILY : Mike & Priscilla Costello Sugarbear, Daisy, PattiAnne & Panda Beloved Great Pyrenees DONOR: Sandra McCrady FAMILY : Sandra McCrady Teddy Bear Beloved Cat DONOR: Elizabeth A. Biddick FAMILY : Elizabeth A. Biddick Tessa (30) Beloved Dog DONOR: Hal & Marty Hendershot FAMILY : The Jackson Family Truman (31) Beloved Friend & Companion DONOR: The Truman Collar website FAMILY : Debby & Terry Fitch Tucker-B Beloved Dog DONOR: Mary Headley FAMILY : Mary Headley & Juliet Headley Smith Vanessa (32) Beloved Greyhound DONOR: Stuart & Cindy Stratton FAMILY : Stuart & Cindy Stratton Wiley (33) Beloved Beagle DONOR: Brenda Heaster & Keith Ritter FAMILY : Brenda Heaster & Keith Ritter Zack Beloved Pet DONOR: Scott Weiner FAMILY : Joan Payden 15 MORRIS ANIMAL FOUNDATION Simple T-shirt leads to lifelong love BY AlEx JImENEz If you had asked her 15 years ago, Sandi Heffner would never have guessed that something so simple as a friend’s choice in dress attire would have changed her life, and the lives of so many others, forever. “Dogs are my family,” she says. “There is simply nothing that compares to the feeling of watching them being born to watching them grow old—it’s truly been a joyous high point in my life.” “My friend was wearing a T-shirt one day that had a Maltese on it,” Sandi explains, “and I commented that I had always wanted a Maltese. Ironically, she knew a show handler who had a Maltese recently retired from the ring that was literally living in a cage.” It was this love for her Maltese and Doberman Pinschers (another breed she has been very involved with), coupled with losing many of them to a wide array of diseases, that propelled her to first donate to Morris Animal Foundation. Appalled at how such a beautiful creature could be living under such sad conditions, Sandi was moved to action. Later that week, and with the permission of the owner, Sandi brought home CH Marcris Heaven Sent, called Angel—the first in her long line of Maltese. Angel’s history in the show ring intrigued Sandi and eventually led her to a close friendship with a handler who, Sandi realized, exemplified the positive side of the sport. Over the years, Sandi and her husband, Steve, became the parents of several other Maltese dogs, even breeding a pair that resulted in their first and only litter. “It kills me to think that there are owners and dogs out there going through what I’ve been through—being torn from a loved one. That’s why I support research, so we can find cures and answers,” Sandi says. In 1995, Sandi strengthened her commitment by becoming a member of the Foundation’s Lamplighter Society, which consists of people with hearts so big that they choose to include Morris Animal Foundation in their estate plans. Sandi’s donations, along with the donations of others, light the way for Foundation-funded studies to prevent, treat and cure disease in dogs, cats, horses and wildlife. Every Lamplighter has a story behind why he or she gives, and Sandi is no exception. Like many others, she donates because of her love for her dogs, those who have died and those who are alive. Yet, unlike many others, her story just happened to begin with a shirt. Learn more After falling in love with her first Maltese, Sandi Heffner became devoted to dogs and Morris Animal Foundation. 16 TolearnmoreabouttheLamplighterSociety, contact Stacie Kelly at 800.243.2345 or [email protected] Create your own cause You can tell your pet’s story and support Morris Animal Foundation’s efforts to help animals live longer, healthier lives with our personal fundraising tools. Simply set up your own personal Webpagetomemorializeabelovedpetoranimallover,recognizeanaccomplishmentor milestone, celebrate a special occasion or just say thank you to a special person. Once you set up your page, you can tell friends and family about your cause and fundraising goals.Thedonationsyouraisewillhelpusadvanceanimalhealthandwelfareworldwide.Visit the“SupportAnimalHealth”sectionatwww.MorrisAnimalFoundation.org to create your cause page today. STAFF BOARD OF TRUSTEES SPONSORS executive officers Thank you to the generous animal lovers who sponsored studies featured in this issue at a level ranging from $3,000 per year to the full cost of the project: Paul Raybould, Executive Vice President Wayne A. Jensen, Chief Scientif ic Off icer John Taylor, Chief Operating Off icer Debby Altendorf, Executive Secretary Mark J. Carter, Chair (Evergreen, CO) Roger H. Bohart, Treasurer (Boulder, CO) board members administrative services Carol Baptiste, Database Administrator Karen Boster, Donations Analyst Serena Everett, Meetings & Operations Manager Dan Liphardt, Technology & Accounting Specialist Darcy Nelson, Donations Analyst Marie Scherer, Accounting Manager development Tilman Adair, Director of Development Letitia Czachor, Canine Cancer Events Manager Megan Hampton, Development Manager Stacie Kelly, Director of Planned Giving Susan Kohut, Development Manager Brenda Lopez, Donor Relations Manager Christy Oakes, Donor Relations Associate Dan Reed, Director of Corporate Partnerships Rebecca Richman, Administrative Assistant Thomas Stevens, Veterinary Outreach Manager Jean Vore, Study Sponsorship Associate MK Wohlenhaus, Volunteer & Events Coordinator marketing & communications Jenny Herren, Online Manager Heidi Jeter, Director of Marketing & Communications Alex Jimenez, Communications Coordinator Tina Martinez, Marketing & Media Relations Manager Kelley Weir, Content Manager April Altman (Fort Worth, TX) Prema Arasu (Pullman, WA) Deborah Davenport (Lecompton, KS) Jim Dickie (Boulder, CO) Robin A. Downing (Windsor, CO) Susan Giovengo (Mason, OH) Amy Hunkeler (Lee’s Summit, MO) Arlene Klein (Sarasota, FL) James A. Kutsch Jr. (Morristown, NJ) Hugh B. Lewis (Vancouver, WA) Lon D. Lewis (Topeka, KS) Patrick O. Long (Corvallis, OR) Betty White Ludden (Los Angeles, CA) Bette M. Morris (Topeka, KS) David R. Morris (Shawnee, KS) Judith Needham (Hunt Valley, MD) Janice Peterson (Ocean Park, WA) Richard J. Swanson (Denver, CO) Melanie Smith Taylor (Memphis, TN) Stanley M. Teeter (Topeka, KS) Dominic Travis (St. Paul, MN) Cheryl A. Wagner (Roswell, GA) Projects Coordinator Cherie Cassel, Senior Grants Specialist Nancy Clark, Study Participants Manager Kristen House, Grants Specialist Tobie McPhail, Director of Scientif ic Programs & Advancements PLEASE USE THE ENVELOPE INSERTED IN THIS ISSUE TO PROVIDE UPDATED INFORMATION AND TO ALERT US OF DUPLICATE MAILINGS. THANK YOU FOR HELPING US SAVE POSTAGE COSTS. Printed on recycled paper with soy-based inks. Anonymous Australian Shepherd Health & Genetics Institute Inc. Batchelor Foundation Inc. Blue Buffalo Foundation for Cancer Research Sandy & Scott Campbell Fred C. & Katherine B. Andersen Foundation George Sydney & Phyllis Redmond Miller Trust Germinder & Associates Hal & Marty Hendershot Dr. & Mrs. Lon D. Lewis Douglas & Kathryn Miller Ann B. Moore North American Falconers Association Pepper Memorial Classic Fund Pfizer Animal Health Portuguese Water Dog Foundation Inc. Precious Cat Inc. Janet Swanson Richard & Kathy Swanson Neil & Sylvia Van Sloun, the Van Sloun Foundation Waltham Foundation Rebecca & Dean M. Willard The Yorkshire Terrier Club of America Foundation Inc. scientific programs & advancement Allen Byrne, Communications & Special American Spaniel Club Foundation HOURS & CONTACT INFO Monday – Friday 8:00 a.m.– 4:30 p.m. Mountain Time TOLL-FREE 800.243.2345 P 303.790.2345 www.MorrisAnimalFoundation.org www.facebook.com/morrisanimal twitter.com/morris_animal E [email protected] PLEASE CALL YOUR VETERINARIAN TO ASK PET HEALTH QUESTIONS. Our staff is unable to provide veterinary medical advice. The opinions of study investigators may not necessarily be those of your companion animal’s veterinarian. Morris Animal Foundation is a nonprofit organization and is tax exempt under the Internal Revenue Service regulation 501(c)(3). Our audited financial statement and state registration information are available upon request. Materials, including photographs and artwork, in this publication may be reprinted only with the permission of Morris Animal Foundation. Please write or call to receive financial information or permission to reprint materials: Morris Animal Foundation, 10200 E. Girard Ave, Suite B430, Denver, Colorado 80231, or call us at 800.243.2345. To remove your name from Morris Animal Foundation’s mailing list, send an e-mail to [email protected] or call us at 800.243.2345. ©2011 Morris Animal Foundation. All rights reserved. 17 10200 East Girard Avenue Suite B430 Denver, Colorado 80231 NONPROFIT ORG. U.S. POSTAGE PA I D *** *** MORRIS ANIMAL FOUNDATION Please use the envelope inserted in this issue to provide updated information and to alert us of duplicate mailings. Thank you for helping us save postage costs.