essential fatty acids

Transcription

essential fatty acids
high quality, concentrated, pure marine lipids to
suit your patient’s needs
Condition
Specific
Products
Highly
Purified
essential
fatty acid
range
Clinically
Effective
Results
Strength
Improved
Patient
Compliance
Metagenics is a Practitioner Only range. This document is for Practitioner distribution only.
Metagenics - The Highest Technology in Purified Fish Oil
Molecular Distillation for Purity and
Concentration of Fish Oils
The Metagenics range of concentrated omega-3 fatty acid formulas
represents the highest technology in purified fish oil. This results in a
final product that exceeds industry standards in purity from common
contaminants including:
• Mercury and other heavy metals
• Pesticides
• Oxidation
All Metagenics fish oils are produced through an advanced molecular
distillation process to ensure purity, batch consistency and effective
clinical results. This process includes the following steps:
• Crude oil extraction from selected freshly-caught saltwater fish.
• Molecular distillation under vacuum at low temperature to extract
only the desired oil fraction and leave behind any pollutants.
• Winterisation – cold condenses, saturates and clarifies the oil.
• Deodorisation.
• Addition of antioxidants to protect from oxidation or rancidity.
At Metagenics we go a step further to ensure stability while the bottled
product is waiting to be consumed. Heat, light and exposure to oxygen
can all contribute to the oxidation of oils. To protect from air exposure,
the air is replaced with nitrogen during two stages of manufacture for
enhanced purity:
• Storage vats of fish oil are nitrogen flushed to protect stored fish
oil from oxidation. They are also sealed from light and kept in a
temperature and humidity controlled TGA approved manufacturing
plant.
• The bottles of fish oil liquids are nitrogen flushed to ensure stability
until opened. This is why our liquid fish oils can be stored below
30°C until opened and then must be refrigerated.
Friends of the Sea
Friends of the Sea is a not-for-profit organisation aimed at conserving
marine habitat and ensuring sustainable seafood. It is an international
body which audits its certified products under independent international
certification bodies against criteria following the Food and Agriculture
Organisation of the United Nations (FAO) guidelines. We are proud
to have a number of our fish oil products certified under this system.
These products are identified by the logo on
our packaging.
Nitrogen Flushing
Fish oils are easily oxidised to lipid peroxides that may increase free
radical damage and be detrimental to health. Testing of Metagenics
fish oil products shows negligible levels of peroxides (see Figure 1).
Figure One: Metagenics Fish Oil Testing Standards
Contaminant
Metagenics EFA Products
Australian Standard
PCBs (polychlorinated biphenols)
< 0.09 mg/kg
< 0.5 mg/kg
Solvents: dioxins, PCDDs, PCDFs
< 0.2 pg/g
Not specified
< 0.1 mg/kg arsenic
< 0.025 mg/kg lead
< 0.01 mg/kg cadmium
< 0.005 mg/kg mercury
< 1 mg/kg arsenic
< 0.5 mg/kg lead
< 0.5 mg/kg cadmium
< 0.5 mg/kg mercury
< 0.01 mg/kg
Complies to British Pharmacopoeia
Peroxide value (PV)
< 5 meq/kg
< 10 meq/kg
Anisidine value (AV)
< 20 meq/kg
< 30 meq/kg
Heavy metals
Pesticides: DDT, DDD, DDE, HCB
Inductively Coupled Plasma Optical
Emission Spectrometer (ICPOES)
2
Origin of Oil
• Small pelagic fish, primarily sardines and anchovies, from the oceans near South America and Africa
• Harvested using eco fishing and sustainable practices
Purification and
Concentration
• Molecular Distillation to increase purity and reduce heavy metal and pesticide levels
• Concentration of oil to increase EPA/DHA content up to 60%
• Antioxidants added to natural triglyceride oil concentrate
Testing and
Purity
• Independent testing to ensure purity exceeds Australian and International Standards
• On site testing at Health World to confirm absence of contaminants such as mercury
Purity of Finished
Product
• On site nitrogen flushing to reduce oxidation of oil
• Liquids and non-enteric coated capsules for purer delivery
• Enteric coated capsules for patients with severe reflux
Patient
Compliance
• High potency liquids for easy once per day dosing
• Concentrated capsules and liquids for improved compliance
• Flavoured liquids and capsules to reduce fishy taste and aftertaste
Great Value
• Higher concentration giving better value for money
• Once per day dosing means greater economy
Clinical
Efficacy
• Concentrated EPA capsules and liquid for mood and inflammation
• Concentrated DHA capsules and liquid for supporting healthy triglyceride levels and the central nervous system
• Improved patient compliance leads to better clinical results
Applications for the Metagenics fish oil range
There are a number of functions essential fatty acids can perform. This is why the Metagenics fish oil range encompasses so many products; each
with a specific purpose.
In healthy people, supplementation with essential fatty acids may:
• Temporarily relieve the pain and inflammation from arthritis.
• Improve mood and cognition.
• Assist in the maintenance of a healthy LDL:HDL cholesterol ratio.
• Assist in the maintenance of triglycerides within the normal range.
• Help maintain cardiovascular health.
• Assist in the improvement of general wellbeing.
Nitrogen Flushing
3
Fatty Acids
Omega-3 Fatty Acids
DOCOSAHEXAENOIC ACID (DHA):
Our bodies naturally produce some DHA, but not enough to ensure
proper biochemical functioning. Therefore, preformed DHA must be
consumed in the diet, or in supplement form, in order to assure an
adequate supply.
The principal dietary source of omega-3 fatty acids is alpha-linolenic
acid (ALA). In a healthy person this is converted into the active
eicosanoids, eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA). However, this conversion depends on enzymes that are prone
to interference from metabolic problems caused by a variety of lifestyle
factors, such as:
Clinical benefits
• Cardiovascular health: helps maintain normal, healthy blood lipid
profiles.
• Diets rich in sugar, alcohol or trans fats from processed foods
• Central Nervous System: DHA plays a crucial role in the growth and
functional development of the central nervous system in infants, is
essential to the healthy functioning of the adult brain and may assist
in cogntition.
• Smoking
• Pollution
• Stress and ageing
• Viral infections and other illnesses
Omega-6 Fatty Acids
This means that in the majority of people the conversion is limited.
Therapeutically, it is much more effective to supplement with EPA and
DHA from fish oil directly.
Linoleic Acid is the primary omega-6 fatty acid, which gets converted
into gamma linolenic acid (GLA). Although most Western diets deliver
an excess of linoleic acid, often it is not converted to GLA because
of metabolic problems caused by poor diet, smoking, pollution,
stress and disease. The best approach to ensure optimal health is to
eliminate these factors where possible and to supplement with GLA-rich
oils such as evening primrose oil. However, it is important to balance
GLA intake with additional omega-3 oils to help prevent its conversion
to pro-inflammatory arachidonic acid.
EICOSAPENTAENOIC ACID (EPA):
EPA is an essential nutrient required for proper biochemical
functioning. EPA must be consumed in the diet, or in supplement form,
to assure an adequate supply.
Clinical benefits
• Inflammatory conditions: helps to regulate the arachidonic acid
cascade, reducing inflammatory eicosanoid formation. Inhibits
COX-2, IL-1 and TNF-alpha.
• Mood regulation: may help maintain normal healthy mood in
patients under stress.
Figure Two: Essential Fatty Acid Metabolism
Omega - 6
Linoleic Acid
LA C 18:2 n6
Omega - 3
6-Desaturase
Gamma-linolenic Acid
GLA C 18:3 n6
Alpha-linolenic Acid
ALA C 18:3 n3
Stearidonic Acid
C 18:4 n3
Elongase
Dihomo
Gamma-linolenic Acid
C 20:3 n6
Eicosatetraenoic Acid
ETA C 20:4 n3
5-Desaturase
Eicosapentaenoic Acid
EPA C 20:5 n3
Arachidonic Acid
AA C 20:4 n6
Pro-Inflammatory
Prostaglandins (PG2)
Leucotrienes (LTB4)
Thromboxanes (TXA)
4
COX-2
Anti-Inflammatory
Prostaglandins (PG3)
Leucotrienes (LTB5)
Thromboxanes (TXA3)
MetaPure EPA/DHA
Capsules
MetaPure EPA/DHA
Liquid
Highly Purified and Concentrated
Marine Lipids
High Purity, Low Reflux,
Concentrated Fish Oil
Contents: 60 (12 days), 120 (24 days) and 240 (48 days) capsules
Order Code: MP60 (60 capsules), MP120 (120 capsules) and
MP240 (240 capsules)
Storage: Store below 30°C
In healthy people, EPA/DHA has been shown to or may:
• Temporarily relieve the pain and inflammation from arthritis.1
• Help maintain cardiovascular health and assist in the maintenance
of triglycerides within the normal range.2,3
• Capsules contain citrus/berry flavour reducing fishy aftertaste.
Each capsule contains:
Concentrated Omega-3 triglycerides-fish
Equivalent Eicosapentaenoic acid (EPA)
Equivalent Docosahexaenoic acid (DHA)
1.0 g
400 mg
200 mg
Directions: Adults: For cardiovascular health: Take 1 capsule daily
with meals.
For assisting the maintenance of triglycerides: Take 5 capsules daily
with meals.
Contents: 100 mL (20 days), 200 mL (40 days) and 500 mL
(100 days) liquid
Order Code: MEPAL (100 mL), MEPAL200 (200 mL) and
MEPAL500 (500 mL)
Storage: Store below 30°C. After opening store at 2°C to 8°C.
(Refrigerate. Do not freeze.)
In healthy people, EPA/DHA has been shown to or may:
• Temporarily relieve the pain and inflammation from arthritis.1
• Help maintain cardiovascular health and assist in the maintenance
of triglycerides within the normal range.2,3
• Easy, once a day prescribing to improve compliance.
Each 5 mL (one metric teaspoon) dose contains:
Concentrated Omega-3 triglycerides-fish Equivalent Eicosapentaenoic acid (EPA)
4.6 g
1.9 g
930 mg
Directions: Adults: Take 5 mL (one metric teaspoon) daily.
For cardiovascular health: Take 1.25 mL (1/4 metric teaspoon) daily.
For temporary arthritic pain relief: Take 5 capsules daily with meals.
Clinical Benefits:
• A meta-analysis of 17 randomised, controlled trials assessed
the effectiveness of EPA and DHA in relieving joint pain and
inflammation: The results reported a significant reduction in joint pain
intensity, joint swelling, morning stiffness and the number of painful
and/or tender joints at a dose of 2.7 grams per day.1 EPA and DHA
exert anti-inflammatory and pain relieving actions via the following
mechanisms:
-- Suppression of COX-2 expression and the inflammatory cytokines
interleukin (IL)-1 alpha and tumour necrosis factor (TNF)-alpha.5
Origin of Oil
•Harvested using eco fishing and sustainable practices
Purification and
Concentration
Testing and
Purity
-- Inhibition of Leukotriene B4 (LTB4) and reduced serum C-reactive
protein levels shown in in vitro and clinical trials.6,7,8
• 2.6 grams of EPA and DHA has been shown, in a randomised,
placebo controlled study of 138 healthy males, to assist in the
maintenance of triglycerides within the normal range. The study
reported a significant difference in triglyceride levels by 14% in the
group taking 2.6 g of EPA and DHA. The study indicated that there was
a direct correlation between increased dosage and improved results.2
• A randomised, double blind, placebo controlled trial measured
the mood and cognitive effects of fish oil: After 35 days, 2.4 grams
of EPA and DHA was associated with an improvement in brain functions
associated with attention, particularly those involving the cortical
processing. There was also a significant improvement in mood states
including anger, anxiety, fatigue and confusion.4
• High quality, purified fish oil: Metagenics Fish Oils are sourced
from small, cold water fish using eco-fishing practices. The fish oil
is molecularly distilled to ensure purity, stability and compliance with
low levels of contaminants. In accordance with our leading stance on
quality and purity, we have ensured that the fish oil concentrates are
well below the Australian allowable levels of heavy metals, pesticides
and solvents.
Free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein,
starches and salt. Free from artificial colours and flavours.
•Small pelagic fish, primarily sardines and anchovies from the oceans near South
America and Africa
Purity of Finished
Product
Patient
Compliance
Great Value
Clinical
Efficacy
•Molecular Distillation to increase purity and reduce heavy metal and pesticide levels
•Concentration of oil to increase EPA/DHA content up to 60%
•Antioxidants added to natural triglyceride oil concentrate
•Independent testing to ensure purity exceeds Australian and International Standards
•On-site testing at Health World to confirm absence of contaminants such as mercury
•On-site nitrogen flushing to reduce oxidation of oil
•Liquids and non-enteric coated capsules for purer delivery
•Enteric coated capsules for patients with severe reflux
•High potency liquids for easy once per day dosing
•Concentrated capsules and liquids for improved compliance
•Flavoured liquids and capsules to reduce fishy taste and after-taste
•Higher concentration giving better value for money
•Once per day dosing means greater economy
•Concentrated EPA capsules and liquid for mood and inflammation
•Concentrated DHA capsules and liquid for supporting healthy triglyceride levels and the
central nervous system
•Improved patient compliance leads to better clinical results
Proudly supporting the
starches and salt. Free from artificial colours, flavours and preservatives.
5
Omega Care for Kids
Omega Brain Care for Kids
Natural Source of Omega-3 Oils
Nutrients for Healthy Brain
Development and Function
Contents: 200 mL liquid (40 doses)
Lemon/Raspberry flavour
Order Code: OCK
Omega 3 has been shown to or may:
• High DHA, phosphatidylserine and vitamin D3 formula for brain
development and cognition.1,2,3
• High potency and purity, once daily dosing for increased compliance.
• Refreshing, peppermint flavour to eliminate fishy aftertaste.
• Assist normal development in young children.1
• Provides EPA and DHA omega-3 fatty acids.
• Unsweetened lemon/raspberry flavour fish oil for optimal
compliance.
Each 5.0 mL dose (one metric teaspoon) contains:
Fish oil - natural
d-alpha-Tocopheryl acetate
Equivalent d-alpha-Tocopherol
4.5 g
817.5 mg
545 mg
12.4 mg
16.9 IU
Directions: Shake well before use. Mix into juice or water, or take directly
off the spoon.
0 to 2 years old: ½ metric teaspoon (2.5 mL) once daily.
2 to 5 years old: 1 metric teaspoon (5 mL) once daily.
5 to 12 years old: 1 metric teaspoon (5 mL) twice daily.
Clinical Benefits:
• Essential fatty acids are important for healthy nervous system
development. DHA may help support the neurological development
of children and support the cell membrane integrity.2,3
• Purity and flavour: Omega Care for Kids marine lipid supplement
has been manufactured to ensure optimal purity, stability and
compliance. The unsweetened lemon/raspberry flavour helps to mask
any unpleasant, fishy aftertaste and to overcome compliance issues
in children.
Free from corn, dairy protein, lactose, eggs, gluten, wheat, yeast, soy protein, starches
and salt. Free from artificial colours, flavours and preservatives.
Contents: 90 mL liquid (18 doses) Peppermint flavour
Order Code: OBCK
Each 5.0 mL dose contains:
Concentrated Omega-3 triglycerides - fish
Equivalent to Eicosapentaenoic acid (EPA)
Equivalent to Docosahexaenoic acid (DHA)
Lecithin (Soy)
Equivalent Phosphatidylcholine
Lecithin liquid – soy phosphatidylserine – enriched soy
Equivalent Soy Phosphatidylserine
Cholecalciferol (Vitamin D3)
Equivalent Vitamin D3 2.3 g
209 mg
1.0 g
1.7 g
575 mg
750 mg
150 mg
20 µg
800 IU
Directions: Shake well before opening.
Children 1 to 4 years: Take 2.5 mL (½ metric teaspoon or by measuring
cap).
Children 5 to 12 years: Take 5 mL (1 metric teaspoon or by measuring
cap). Take once daily.
Clinical Benefits:
• DHA may help to support the development of a normal, healthy
brain:1 DHA is required for cognitive development and is essential
for cell membrane flexibility and healthy synaptic function.4 DHA is
an integral component of neural membrane phospholipids to help
modulate functional activity in cortical attention networks of the brain.5
• Phosphatidylserine may help to support normal healthy brain
and nervous system function: The human brain contains high
levels of phosphatidylserine, a precursor to acetylcholine which may
be involved in memory.6
• Highly purified and concentrated DHA for clinically effective
results: Metagenics Fish Oils are sourced from small, cold water
fish using eco-fishing practices. The fish oil is molecularly distilled to
ensure purity, stability and compliance with low levels of contaminants.
In accordance with our leading stance on quality and purity, we have
ensured that the fish oil concentrates are well below the Australian
allowable levels of heavy metals and pesticides.
Free from corn, dairy protein, lactose, eggs, gluten, wheat, yeast, starches and salt.
Free from artificial colours and preservatives. Contains steviol glucosides.
Metagenics recognises the rise in childhood diseases. To help raise awareness for the management
of these conditions we are proud to announce our major sponsorship of the Mindd Foundation.
The Mindd Foundation is a not for profit Health Promotion Trust set up and run by a team of patients,
medical doctors and healthcare professionals. Mindd aims to promote improved care for a range of
acute and chronic health disorders. The Advisory Board members of the Mindd Foundation includes
Dr Martha Herbert, Dr Elizabeth Mumper, Dr Nancy O’Hara, Dr Anthony Underwood, Michael
Fenech (PhD, CSIRO), Dr Robyn Cosford, Dr Frank Golik and Dr Marilyn Dyson as well as many other dedicated practitioners, parents and patients.
The Mindd Foundation understands the importance of nutritional medicine and supplementation for childhood health, especially the significance of
the quality and purity of supplements. That is why The Mindd Foundation has chosen Metageincs as a major supporter to help them provide quality
nutrition, education, support and advice.
Metagenics is excited to be affiliated with Mindd and we look forward to our association helping more children and their families live happier,
healthier lives.
6
Omega Brain Plus
Meta EPA/DHA
Supports a Healthy Brain and
Cognitive Function
High Potency Marine Lipids Low Reflux
Contents: 190 mL liquid (19 days) Peppermint flavour
Order Code: OMBP
Storage: Store below 30°C. After opening store at 2°C to 8°C. (Refrigerate. Do not freeze.)
Ingredients in Omega Brain Plus have been clinically shown to or may
help to:
• Support normal, healthy brain development and function.1,2
• Improve memory in people with age-related cognitive decline.3
• Sustainably sourced* tocotrienols for DNA protection.4
Each 5.0 mL dose contains:
Lecithin
Equivalent Phosphatidyl choline
Lecithin liquid - soy phosphatidylserine-enriched soy Equivalent Soy phosphatidylserine Tocotrienols complex - palm
Cholecalciferol
Equivalent Vitamin D3
2.3 g
209 mg
1.0 g
1.5 g
520 mg
750 mg
150 mg
80 mg
12.5 µg
500 IU
Directions: Shake well before opening.
Adults: Take 5.0 mL (1 metric teaspoon or by measuring cap) twice daily.
Clinical Benefits:
• Omega Brain Plus provides 1000 mg of DHA per teaspoon. DHA
is required for brain and cognitive development5 and has been
shown to modulate functional activity in cortical attention networks.
Ex-vivo research has demonstrated a dose dependent increase in
erythrocyte DHA composition. A 47% increase was observed after a
400 mg dose compared to a 70% increase after 1200 mg
supplementation.7
• Phosphatidylserine (PS) is a key constituent of brain and nerve
cell membranes and may help to improve memory in people with
age-related cognitive decline.8,9 A double-blind, placebo controlled
study using 494 patients, over the age of 65, examined the benefits
of 300 mg of PS on men and women with moderate to severe agerelated cognitive decline.10 Significant improvements in behaviour and
cognitive performance, including memory recall, were distinguished in
the PS group, compared to placebo (see Figure Three).11
Contents: 60 (10 days), 120 (20 days) and
240 (40 days) enteric coated capsules
Order Code: MEPA (60 capsules), METAP (120 capsules) and
MEPA240 (240 capsules)
In healthy people, fish oil has been shown to or may:
• Temporarily relieve the pain and inflammation of arthritis.1
• Assist the maintenance of triglycerides within the normal range.2
• Enteric coated to reduce fishy after taste.
Equivalent Eicosapentaenoic acid (EPA) Equivalent Docosahexaenoic acid (DHA) 1020 mg
300 mg
200 mg
Directions: Adults: Take 2 capsules three times daily.
Children two to 12 years: Take 1 capsule three times daily.
Clinical Benefits:
• A meta-analysis of 17 randomised, controlled trials assessed
the effectiveness of EPA and DHA in relieving joint pain and
inflammation: The results reported a significant reduction in joint
pain intensity, joint swelling, morning stiffness and the number of
painful and/or tender points at a dose of 2.7 grams per day.1 EPA
and DHA exert anti-inflammatory and pain relieving actions via the
following mechanism:
-- Suppression of COX-2 expression and the inflammatory cytokines
interleukin (IL)-1 alpha and tumour necrosis factor (TNF)-alpha.3
• 2.6 grams of EPA and DHA has been shown, in a randomised,
placebo controlled study of 138 healthy males, to assist in the
maintenance of triglycerides within the normal range. The study
reported a significant difference in triglyceride levels by 14% in the
group taking 2.6 g of EPA and DHA. The study indicated that there was
a direct correlation between increased dosage and improved results.2
Buschke Selective
Reminding (memory
recall) Test Score
Figure Three: Improvements in Memory Recall with
Phosphatidylserine Supplementation.16
32
31
30
29
28
27
26
25
Placebo
Baseline
PS
3 months post PS treatment
Cenacchi T, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter
study on efficacy of phosphatidylserine administration. Aging (Milano). 5(2):123-33. 1993
Omega Brain Plus represents the latest technology in purified fish oils. The omega-3
triglycerides are purified via molecular distillation then tested for pesticides, heavy
metals and solvent residues. The omega-3 triglycerides are sourced from small, cold
water fish using eco-friendly practises.
Free from corn, dairy protein, lactose, eggs, gluten, wheat, nuts,
starches and salt.Free from artificial colours and preservatives.
Sweetened with rebaudioside (stevia) and contains no artificial flavours.
* Derived from palm oil which is sourced from a member of the Round
Table on Sustainable Palm Oil (RSPO).
7
Ultra DHA
Ultra DHA Liquid
Low Reflux DHA Concentrate for
Cognitive Function and Heart Health
High Purity DHA Rich Fish Oil
Contents: 100 mL liquid (20 days) Lemon flavour
Order Code: UDHA
Contents: 90 enteric coated capsules (22 days)
Order Code: UDHAC
In healthy people, DHA concentrate has been shown to or may:
• Improve cognitive and neuronal function.
• Support healthy heart function and normal triglyceride levels.2,5
• Enteric coated to reduce fishy aftertaste.
1,2
Concentrated Omega-3 triglycerides – fish
1.0 g
432.3 mg
90.5 mg
Directions: Adults: Take 2 capsules twice daily.
Clinical Benefits:
• May improve cognitive and neuronal function: DHA is a
predominant component of neural membranes in the brain and the
retina. Omega-3 fatty acids including DHA have been shown in a
randomised, double blind, placebo controlled trial to improve cognitive
function by decreasing mood states such as anger, confusion, and
anxiety.1 Adequate dietary intake of DHA is particularly important
during the third trimester of pregnancy until 18 months after birth to
support the brain growth spurt that takes place.2 This assists optimal
development of the brain, motor skills and visual acuity in the infant.
• May support healthy heart function: DHA has been shown to
improve endothelial function and decrease resting heart rate.3 In an
animal study, DHA also demonstrated a reduction in vascular wall
thickness.4 In healthy individuals, fish oil containing DHA may assist
in the maintenance of triglycerides within the normal range.5
• Natural unsweetened lemon flavour.
• High quality fish oil to ensure purity and stability.
• Easy once a day prescribing, providing 2 g of DHA.
Ingredients:
Fish oil – natural (98.0%), Natural Lemon flavour (1.5%), antioxidants
– Tocopherols concentrate mixed, Rosemary extract, Ascorbyl palmitate.
Directions: Adults: Take 2.5 to 5 mL (1/2 to 1 metric teaspoon) daily.
Nutritional Information:
Servings per package: 20
Serving size: 5.0 mL
Per 5.0 mL
Per 100 mL
Energy
171 kj
(41.7 cal)
3426 kj
(833 cal)
Protein
0g
0g
4.6 g
93 mg
<46 mg
4.2 g
2.9 g
463 mg
2g
370 mg
92.6 g
1.9 g
<921 mg
83.3 g
59.3 g
9.3 g
40.7 g
7.4 g
Fat
- Total
- Saturated
- Trans
- Polyunsaturated
- Omega-3 fatty acids
- Eicosapentaenoic acid (EPA)
- Docosahexaenoic acid (DHA)
- Monounsaturated
Average values shown
Benefits:
• Highly purified and concentrated DHA for clinically effective
results: Metagenics uses high quality fish oils as a source of EPA and
DHA to ensure purity, stability and compliance. In accordance with our
leading stance on quality and purity, we have ensured that the fish oil
concentrates are well below the Australian allowable levels of heavy
metals and pesticides.
Special purpose food.
8
Ultra EPA
Ultra EPA Liquid
Low Reflux EPA Concentrate for
Mood Support
High Purity EPA Rich Fish Oil
Order Code: UEPAC
In healthy people, EPA concentrate has been shown to or may:
• Easy once a day prescribing, providing 1.8 g of EPA.
• Temporarily relieve the pain of arthritis.1
• Improve mood.2
Concentrated Omega-3 triglycerides-fish Equivalent Eicosapentaenoic acid (EPA)
Contents: 100 mL liquid (20 days)
Lemon flavour
Order Code: UEPA
1.0 g
500 mg
100 mg
Directions: Adults: Take 5 capsules daily.
Clinical Benefits:
• Arthritic conditions: Fish oil containing EPA may help reduce joint
inflammation, temporarily relieve pain and improve joint mobility in
arthritis and rheumatoid arthritis.1,3 EPA and DHA have been shown
to exert their anti-inflammatory action via the following mechanisms:
-- Inhibition of COX-2, IL-1 and TNF-alpha.4
-- Reduction in pro-inflammatory cytokines by competing with
arachidonic acid in cell membranes, a precursor to inflammatory
mediators.5
• A randomised, double blind, placebo controlled trial measured
the effect of EPA and DHA on improving mood: The results
reported a significant decrease in negative behaviour including anger
and anxiety and an increase in vigour.2 The possible mechanism to
explain the role of EPA in mood improvement is the regulation of
neurotransmitters, including serotonin and dopamine.5
Ingredients:
Fish oil – natural, Natural Lemon flavour, antioxidants – Tocopherols
concentrate-mixed, Rosemary extract and Ascorbyl palmitate.
Directions: Adults: Take 2.5 to 5.0 mL (½ to 1 metric teaspoon) daily.
Nutritional Information:
Servings per package: 20
Serving size: 5.0 mL
Per 5.0 mL
Per 100 mL
Energy
171 kj
(41.7 cal)
3426 kj
(833 cal)
Protein
0g
0g
4.6 g
463 mg
<46 mg
3.5 g
2.8 mg
1.85 g
463 mg
695 mg
92.6 g
9.3 g
<921 mg
69.5 g
55.6 g
37 g
9.3 g
13.9 g
Fat
- Total
- Saturated
- Trans
- Polyunsaturated
- Omega-3 fatty acids
- Eicosapentaenoic acid (EPA)
- Docosahexaenoic acid (DHA)
- Monounsaturated
Average values shown
Benefits:
• High quality fish oil: Metagenics uses high quality fish oils as a
source of EPA and DHA to ensure purity, stability and compliance. In
accordance with our leading stance on quality and purity, we have
ensured that the fish oil concentrates are well below the Australian
allowable levels of heavy metals and pesticides.
Special purpose food.
9
Krill Oil
Meta Oil
One a Day, Clinically Trialled Krill Oil
To Help Maintain Normal Healthy
Metabolism
Contents: 30 softgel capsules (30 days)
Order Code: KRL
Contents: 200 mL liquid (40 days) Orange flavour
Order Code: MO
In healthy people NKOTM krill oil may:
• Help maintain healthy cholesterol levels.1
• Assist in the maintenance of healthy LDL/HDL cholesterol ratio.1
• One a day capsule to improve patient compliance.
Euphausia superba oil (Krill NKOTM)
1.0 g
Directions: Adults: Take 1 capsule daily with food.
Clinical Benefits:
• A randomised, double blind, placebo controlled trial was
completed on 120 subjects using NKOTM krill oil. NKOTM krill oil
may assist in the maintenance of a healthy LDL:HDL cholesterol
ratio in healthy people. After 12 weeks, the group taking 1 g of krill
oil daily had a 13.4% difference in mean total cholesterol, where the
group taking 2 g of krill oil had an 18.1% difference in mean total
cholesterol. Additionally, HDL was also affected (Figure Four).1 Krill oil
may also assist in the maintenance of triglycerides within the healthy
range in healthy people. The mechanism behind krill oil’s effect on
cholesterol may be owed to its unique molecular composition of
phospholipids and omega-3 acids.1
Average % change over 12 weeks
Figure Four: Krill Oil May Help Maintain Healthy
Cholesterol Levels.1
45%
In healthy people, fish oil has been shown to or may:
• Maintain healthy metabolism.1
• Assist the maintenance of healthy triglyceride levels.2
• Use in conjunction with the Shake It Professional Weight Management
Program.
Each 5.0 mL (one metric teaspoon) dose contains:
Fish oil - natural
Sesame oil
Linseed oil (Flaxseed oil)
d-alpha-Tocopheryl Acetate
2.1 g
378 mg
252 mg
1.84 g
465 mg
11 mg
15 IU
Directions: Shake well before use.
Adults: Take 1 to 4 metric teaspoons (5-20 mL) twice daily.
Clinical Benefits:
• PPARs have been shown to activate thermogenesis and increase
energy expenditure (Figure Five).3 Fish oil has been shown to activate
the Peroxisome Proliferator Activated Receptors (PPARs). The PPARs
play a critical physiological role as lipid sensors and regulators of lipid
metabolism by reducing fatty acid synthesis, diverting fatty acids into
phospholipid synthesis and increasing hepatic uptake of triglycerides.4,5
Figure Five: The Peroxisome Proliferator Activated
Receptors (PPARs).3
35%
25%
15%
5%
0%
-5%
-15%
-25%
-35%
Total
Cholesterol
1 g Krill Oil
HDL
Cholesterol
Fish Oil
LDL
Cholesterol
Placebo
Bunea R, El Farrah K and Deutsch L. Evaluation of the effects of Neptune Krill Oil on the
clinical course of hyperlipidemia. Altern Med Rev. 2004 ;9(4):420-8.
• Highly stabilised EPA/DHA with antioxidant properties: Krill oil is
high in naturally occurring antioxidant components, such as vitamins
A and E and the carotenoid astaxanthin. One of the mechanisms
that krill oil may work by is to reduce lipid peroxidation.2 Krill oil may
help maintain cardiovascular health in healthy individuals.1 The EPA
and DHA found in krill oil are highly bioavailable as they are linked
to phospholipids, improving the transport of these fatty acids through
the intestinal wall.1,2
Not suitable for patients with shellfish or seafood allergies (krill is a small crustacean).
10
• In a randomised, double blind placebo controlled trial; fish oil
was shown to assist the maintenance of healthy triglyceride levels
in normal people: Serum triglycerides were significantly reduced by
14% in the fish oil group.2
Free from corn, dairy protein, lactose, eggs, gluten, wheat, yeast, soy protein, starches
and salt. Free from artificial colours, flavours and preservatives. Contains sucralose.
Omega EFA with Vitamin E
Odourless Fish Oil, Vitamin E and Evening Primrose Oil for Cardiovascular Health
Clinical Benefits:
Order Code: EFA
• A study of 89 females evaluated the efficacy of evening primrose
oil in relieving breast pain: The results reported a significant
75.64% response to evening primrose oil at 500 mg twice per day.1
An additional clinical trial in 66 women with cyclical breast pain also
reported a 97% response rate with evening primrose oil.3
Omega EFA and Vitamin E has been shown to or may:
• Relieve premenstrual breast pain.1
• Support heart health.2
Fish oil – natural
Evening Primrose Oil Equivalent Gamma-Linolenic Acid (GLA)
d-alpha-Tocopherol
500 mg
90 mg
60 mg
500 mg
50 mg
33.6 mg
50 IU
• May support heart health: Vitamin E has been shown to support
the cardiovascular system in healthy individuals by inhibiting platelet
aggregation and adhesion, inhibiting smooth muscle cell proliferation
and improving endothelial function.2 Omega 3 may also assist in the
maintenance of normal, blood lipid levels in healthy people.4
Directions: For general health and wellbeing: Adults: Take 1 capsule
three times daily.
For heart health, arthritis, and skin conditions: Adults: Take up to 4
capsules three times daily.
In-Clinic Promotional Materials
Also available for your clinic:
•
Patient Information Brochure - Order Code: BR30.
•
Tear Off Pad - Essential Fatty Acids - Order Code: TOP3
These flyers explain the quality and efficiency of Natural
Medicine that you prescribe compared to cheaper, less
effective products available in the market place. These flyers
help to build strong patient compliance and should be handed
to your patients with every Metagenics prescription.
11
Essential Fatty Acid Range Summary
Form
Product Highlights
Page
MetaPure
EPA/DHA
Capsules
5
Highly Purified and
Concentrated Marine
Lipids.
• Help maintain cardiovascular health and assist in the
maintenance of triglycerides within the normal range.
• Capsules contain citrus/berry flavour reducing fishy aftertaste.
MetaPure
EPA/DHA
Liquid
5
High Purity, Low Reflux,
Concentrated Fish Oil.
• Help maintain cardiovascular health and assist in the
maintenance of triglycerides within the normal range.
• Easy, once a day prescribing to improve compliance.
Liquid
• EPA: 1.9 g
• DHA: 930 mg
• Citrus/berry flavour
Omega
Care for
Kids
6
Natural Source of
Omega-3 Oils.
• Assist normal development in young children.
• Provides EPA and DHA omega-3 fatty acids.
• Unsweetened lemon/raspberry flavour fish oil for optimal
compliance.
Liquid
• EPA: 817.5 mg • DHA: 545 mg • Lemon/raspberry
flavour
Omega
Brain
Care for
Kids
6
Nutrients for Healthy
Brain Development
and Function.
• High DHA, phosphatidylserine and vitamin D3 formula for
brain development and cognition.
• High potency and purity, once daily dosing for increased
compliance.
• Refreshing, peppermint flavour to eliminate fishy aftertaste.
Liquid
• EPA: 209 mg
• DHA: 1 g
• Peppermint flavour
Omega
Brain Plus
7
Supports a Healthy
Brain and Cognitive
Function.
• Support normal, healthy brain development and function.
• Improve memory in people with age-related cognitive decline.
• Sustainably sourced* tocotrienols for DNA protection.
Liquid
• DHA: 1.0 g
• Soy Phosphatidylserine
150 mg
Meta
EPA/DHA
Capsules
7
High Potency Marine
Lipids - Low Reflux.
• Temporarily relieve the pain and inflammation of arthritis.
• Assist the maintenance of triglycerides within the normal range.
• Enteric coated to reduce fishy after taste.
Enteric • EPA: 300 mg
Coated • DHA: 200 mg
Capsule
Ultra
DHA
Capsules
8
Low Reflux DHA
Concentrate for
Cognitive Function and
Heart Health.
• Improve cognitive and neuronal function.
• Support healthy heart function and normal triglyceride levels.
Enteric • EPA: 432.3 mg Coated • DHA: 90.5 mg
Capsule
Ultra
DHA
Liquid
8
High Purity DHA Rich
Fish Oil.
• Easy once a day prescribing, providing 2 g of DHA.
Ultra EPA
Capsules
9
Low Reflux EPA
Concentrate for Mood
Support.
• Temporarily relieve pain of arthritis.
• Improve mood.
Ultra EPA
Liquid
9
High Purity EPA Rich
Fish Oil.
• Easy once a day prescribing, providing 1.8 g of EPA.
Krill Oil
10
One a Day, Clinically
Trialled Krill Oil.
• Help maintain healthy cholesterol levels.
• Assist in the maintenance of healthy LDL/HDL cholesterol ratio.
• One a day capsule to improve patient compliance.
Meta Oil
10
To Help Maintain
Healthy Metabolism.
• Maintain healthy metabolism.
• Assist the maintenance of healthy triglyceride levels.
• Use in conjunction with the Shake It Professional Weight
Management Program.
Omega
EFA with
Vitamin E
11
Odourless Fish Oil,
Vitamin E and Evening
Primrose Oil for
Cardiovascular Health.
• Relieve premenstrual breast pain.
• Support heart health.
A division of Health World Limited
741 Nudgee Rd, Northgate,
Qld. Australia 4013
Ph: (07) 3117 3300
Fax: (07) 3117 3399
Ph: Country and Interstate 1800 777 648
A division of Health World (NZ) Limited
PO Box 35383, Browns Bay,
Auckland, New Zealand 0753
PO Box 675
Virginia BC, Qld. 4014
www.metagenics.com.au
[email protected]
[email protected]
Ph: (09) 478 2540 or 0508 227 744
Fax: (09) 478 2740 or 0508 227 733
12
www.metagenics.co.nz
[email protected]
Softgel • EPA: 400 mg
Capsule • DHA: 200 mg
Liquid
• EPA: 463 mg • DHA: 2 g
• Lemon flavour
Coated • DHA: 100 mg
Capsule
Liquid
• EPA:1.8 g • DHA: 463 mg • Lemon flavour
Capsule • Krill Oil: 1 g
Liquid
• EPA: 378 mg • DHA: 252 mg
• Orange flavour
Coated • DHA: 60 mg Capsule
• GLA: 50 mg • Vitamin E: 50 IU
MET3094 - 05/12
Key Descriptor
In healthy people, ingredients in this product has
been shown to or may:
Product

essential fatty acids

Transcription

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