Program 2007 - World Conference on Regenerative Medicine
Transcription
Program 2007 - World Conference on Regenerative Medicine
Program October 18–20, 2007 Germany | Congress Center Leipzig 3rd WORLD CONGRESS ON REGENERATIVE MEDICINE New Products for Diagnostics and Therapy www.regmed.org © N. zur Nieden: Hanging drops for stem cell cultivation TRM Leipzig You would like to realise your ideas of research in the area of regenerative medicine? We are pleased to meet you! Translational Centre for Regenerative Medicine (TRM-Leipzig) Molecules and Cells in Tissue Regeneration From Concept to Clinical Application The mission of the TRM-Leipzig is to conduct and support interdisciplinary research for regenerative medicine. We provide an effective link between academia, research institutions, and small- and medium-sized biotechnology companies. Our task is to translate conceptual research into clinical practice and to develop and train internationally competitive basic and clinical scientists. 3rd World Congress on Regenerative Medicine October 18–20, 2007 Congress Center Leipzig, Germany Organizer Fraunhofer Institute for Cell Therapy and Immunology, Leipzig You will find us at floor 1 opposite lecture hall 1 Welcome to our TRM – Session on 3rd World Congress on Regenerative Medicine - Space Medicine Meets Regenerative Medicine Saturday, October 20, 2007 11.00 am - 12.30 pm 01.30 pm - 03.00 pm lecture hall 1 In Cooperation with: Translational Centre for Regenerative Medicine 2 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E Saxony State Ministry for Economic Affairs and Labor OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 3 WELCOME ADDRESS BURKHARD JUNG WELCOME ADDRESS FRANK EMMRICH I warmly welcome you to the 3rd World Congress on Regenerative Medicine in the Congress Center Leipzig. For the third time, researchers and industry are coming together in the context of this international event. The Free State of Saxony and Leipzig in particular play a crucial role in the development of regenerative medicine in Germany. In Leipzig, the strengths are many-fold: the high-level infrastructure in the field of medical sciences; the prestigious medical faculty of the Universität Leipzig; three Max-PlanckInstitutes; one of the five faculties for veterinary medicine in Germany and a renowned Cardiac Center. Additionally, the BIOCITY as a biotechnological and biomedical centre, houses several companies and institutions. One of the latest institutions, founded in April 2005, which has its focus on regenerative medicine is the Fraunhofer-Institute for Cell Therapy and Immunology (IZI) which is also the organizer of this World Congress. The establishment of the Fraunhofer-Institute was a critical step on the way to developing a regional focus on regenerative medicine in Leipzig. A unique strength of the region is the growing expertise in the translation of basic research into the clinic. Almost one year ago, Leipzig won special funding through a national competition for a centre for regenerative medicine that was initialized by the “Bundesministerium für Bildung und Forschung” (Federal Ministry of Education and Research, BMBF). The Translational Centre for Regenerative Medicine was opened in October 2006 under the direction of Prof. Frank Emmrich. The Centre unites institutes of over five faculties from the Universität Leipzig, many non-academic research institutions, as well as local small- and medium-sized industrial partners. These facts demonstrate the importance of Leipzig as a scientific centre. Events such as the 3rd World Congress on Regenerative Medicine strengthen and underline this fact. Participants of this large-scale event are traveling from all across the globe and will be able to see and experience regenerative medicine first-hand in Leipzig. If you have the chance to go on a sight-seeing tour through Leipzig, don’t miss the amazing and unique places, buildings and the charming atmosphere of the city and its centre. Museums, such as the Museum of Fine Arts, the opera, theatre or cabaret offer you many possibilities to enjoy an exciting stay in Leipzig. I hope that this congress will be a very successful one for each of you with much to learn, to hear, to discuss and to use for your prospective work. In addition to the scientific exchange, I trust you will keep in mind the city of Leipzig with its many facets. After the positive responses in the wake of the first World Congress on Regenerative Medicine in 2003, followed by the second – even larger – second WCRM in 2005, Leipzig is proud to be host for the third WCRM in 2007 again. The congress offers an international forum for researchers and industrials from tissue engineering to nanomedicine to meet and discuss new developments in the rapidly growing field of regenerative medicine. Representatives from many countries will gather to present their latest findings in the fields of stem cells, umbilical cord cells, cartilage and bone repair, neuro-regeneration, immunology, skin and soft tissue repair as well as tissue engineering, scaff olds and imaging. Discussion and exchange of information on these topics will extend from academia to industry. Additionally numerous sponsors and exhibitors from biotech to pharma will present new technologies and in this contribute to the important conversation between science and industry. The infrastructure for Regenerative Medicine in Leipzig, which is key for the success of this event, is still growing, for example over the next 5 years the German granting agency (BMBF) is funding Leipzig researchers for a minimum of 11 Mio euros annually. Some of the institutes which are beneficiaries include Biotechnical and Biomedical Centre (BBZ) of the University of Leipzig, the new Translational Centre for Regenerative Medicine (TRM) as well as the Fraunhofer Institute for Cell Therapy and Immunology (IZI), who is proud to be the organizer of the 3rd WCRM. Leipzig itself was famously called “little Paris” by the renowned poet Johann Wolfgang von Goethe who lived here for many years, and no visit would be complete without a tour through the old city with its charming architecture and lovely atmosphere. I am delighted to welcome you to Leipzig for the 3rd World Congress on Regenerative Medicine and I wish all of us interesting and fruitful days with top-class presentations, exciting discussions and positive impressions not only of the congress but also of Saxony and one of its brightest jewels – Leipzig. Professor Frank Emmrich, Conference President Burkhard Jung, Lord Mayor of Leipzig 4 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 5 TABLE OF CONTENTS Scientific board and local organizing commitee 9 Overview congress venue 10–11 Program at a glance 12–13 2 nd Fraunhofer Life Science Symposium Leipzig 2007 – Your best solution for precise results Tissue Regeneration in Veterinary Medicine 14–15 Thursday, October 18, 2007 16–21 Friday, October 19, 2007 22–30 Saturday, October 20, 2007 32–37 Overview poster exhibition Thermo Fisher Scientific Inc. is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. 3rd World Congress on Regenerative Medicine Floor +1, booth 38 From routine testing to complex research and discovery, the industry-leading instruments answer "what is it" and "how much is there". Thermo Fisher Scientific helps tackle tough analytical challenges using advanced technologies ranging from mass spectrometry and elemental analysis to chromatography, molecular spectroscopy, and microanalysis. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. 38 Posters 39–49 Evening functions 50–51 Sponsors & Exhibitors 52–53 Exhibition plans 54–55 General information 56–57 How to get to the Congress Center Leipzig 59 Editorial deadline: October 5, 2007 6 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 7 www.pH1.de SCIENTIFIC BOARD Tie up to Achievements! In Leipzig, biotechnology is given top priority. Proof for this: the new BIO CITY LEIPZIG. ● Where industry, science and research live and work together. ● Where knowledge is not only shared but multiplied. ● Where young companies and the University of Leipzig set new standards in biotechnology. ● Where you find uniquely favourable conditions. www.bio-city-leipzig.de 8 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E Barthel, Henryk University of Leipzig, Germany Bulte, Jeff The Johns Hopkins University School of Medicine, Baltimore, MD, USA Emmrich, Frank Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany Engel, Wolfgang Georg-August-Universität, Göttingen, Germany Hasenfuß, Gerd Georg-August-Universität, Göttingen, Germany Hengstler, Jan G. University of Leipzig, Germany Hutmacher, Dietmar W. Queensland University of Technology, Kelvin Grove, Australia Kerr, Douglas Johns Hopskins TM Center, Baltimore, MD, USA Lin, Feng-Huei Institute of Biomedical Engineering, National Taiwan University, Tapei, Taiwan Mason, Chris University College London, UK Mertsching, Heike Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany Mol, Anita Eindhoven University of Technology, The Netherlands Orive, Gorka University of the Basque Country, Vitoria, Spain Pfützner, Andreas Institute for Clinical Research and Development (IKFE), Mainz, Germany Sykova, Eva Institute of Experimental Medicine, Prague, Czech Republic Temiz Artmann, Aysegül Institute of Bioengineering, University of Applied Sciences Aachen, Germany Williams, David Loughborough University, UK LOCAL ORGANIZING COMMITEE Einspanier, Almuth Faculty of Veterinary Medicine, University of Leipzig, Germany Emmrich, Frank Fraunhofer Institute for Cell Therapy and Immunology Faber, Sonya Fraunhofer Institute for Cell Therapy and Immunology Gerdes, Wilhelm Fraunhofer Institute for Cell Therapy and Immunology Oechtering, Gerhard Faculty of Veterinary Medicine, University of Leipzig, Germany Seeger, Johannes Faculty of Veterinary Medicine, University of Leipzig, Germany OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 9 OVERVIEW CONGRESS VENUE Floor 0 Elevator Catering Lecture Hall 3 Exhibition area Catering Foyer Exhibition area Exhibition area Speaker Preview Elevator Elevator Catering Exhibition area Exhibition area Floor –1 Floor +1 Lecture Hall 4 Lecture Hall 5 Elevator Elevator Catering Elevator Elevator Lecture Hall 1 Counter, Check-in Foyer Lounge Catering Foyer West Foyer Ost Poster exhibition Exhibition area Exhibition area Entrance 10 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 11 PROGRAM AT A GLANCE O C T O B E R 17, 2 0 0 7 7:30 pm SPECI A L DINNER LEC T URE AT THE OLD S TOCK E XCH A NGE OCTOBER 18, 2007 9:00–10:30 am R O O M 10 Stem Cell Technology in Mammals 10:30–11:00 am C O F F E E B R E A K / B R E A K FA S T HALL 5 p. 14 Thermo Fisher Scientific – Partner of Regenerative Medicine Research – Brunch Symposium Immunology and Vaccines in Veterinary Medicine p. 15 11:00 am–12:15 pm p. 17 HALL 4 Symposium p. 18 GRM – German Society for Regenerative Medicine Why invest in an innovative field? HALL 1 REGENERATE General Assembly of the European Network for Regenerative Medicine EEIG p. 18 (ROOM 9) HALL 3 Bioengineering of Soft Tissue Membranes p. 20 Progenitor Cell Therapy, LLC – Industry Symposium Stem Cell and Tissue Bioengineering OPENING CEREMONY 1:00–2:00 pm L U N C H (12 :15 –1: 0 0 p m) 2:00–3:30 pm Tissue Engineering in Veterinary Medicine 3:30–4:00 pm 4:00–5:30 pm COFFEE BREAK Cell Therapy in Veterinary Medicine 5:30 pm G E T-T O G E T H E R I N T H E E X H I B I T I O N A R E A | P O S T E R S E S S I O N ( 5 : 3 0 –7: 3 0 P M) p. 15 Industry Technology: Industry Insights and Strategic Direction p. 17 Immunologic Tissue Acceptance p. 18 Stem Cells in Diabetes p. 15 New Industrial Technology Platform p. 18 Symposium p. 19 Stem Cells: Cardiac ESAO – European Society of Artificial Organs Towards Bioartificial Organs p. 20 p. 19 p. 19 Biophysics in Cell and Tissue Research p. 21 p. 20 Symposium p. 21 ISAC – International Society for Analytical Cytology Cytometry – A Key Technology in Regenerative Medicine O C T OBER 19, 2 0 0 7 HALL 1 Stem Cells: Emerging Developments HALL 4 p. 23 Vascular Remodelling and Angiogenesis p. 25 HALL 5 Cartilage and Bone Engineering HALL 3 p. 27 Stem Cells: Neuronal 10:30–11:00 am 11:00 am–12:30 pm COFFEE BREAK Law for hESC Research, Reimbursment, Ethics and Advanced Therapy Products p. 23 Metabolism in Regenerative Medicine p. 25 Biomaterials and Scaffolds for Regeneration I p. 27 NanoMicrostructures in Diagnostics, Therapy and Therapeutic Monitoring p. 29 12:30–1:30 pm 1:30–3:00 pm LUNCH BREAK Embryonic Stem Cells p. 24 Tissue Engineering I p. 26 Symposium ESOT – European Society for Organ Transplantation Stem Cell Transplantation and Immunomodulation p. 28 NanoMicrostructures in Diagnostics, Therapy and Therapeutic Monitoring: Neuroperspectives p. 30 3:00–3:30 pm 3:30–5:00 pm COFFEE BREAK Pluripotency and Gamete Derived Stem Cells p. 24 Symposium ETCS – European Tissue Culture Society Stem Cells and Tumorigenesis p. 26 Stem Cells: Liver p. 28 Innovative Methods and Drug Delivery Technologies p. 30 5:00–6:30 pm Regulatory Affairs in Advanced Therapy Products p. 24 Pluristem Life Systems, Inc. p. 26 Placental Cells in Cell Therapy Industry Symposium Immunologic Issues in Regenerative Medicine p. 28 Imaging of Regeneration I p. 30 8:00 pm S O C I A L E V E N I N G AT M O R I T Z B A S T E I HALL 4 p. 33 Symposium ICRS – International Cartilage Repair Society How to Reconstruct Injured Cartilage p. 34 HALL 1 Biomaterials and Scaffolds for Regeneration II HALL 5 p. 35 Neurodegeneration and Repair p. 36 8:30–10:30 am p. 29 OCTOBER 20, 2007 12 8:30–10:00 am R O O M 11 Medical Applications of ncRNA 10:00–11:00 am 11:00 am–12:30 pm COFFEE BRE AK | POSTER SESSION | POSTER AWARD Medical Applications of ncRNA, continued p. 33 Materials, Surfaces and Implants p. 34 Space Medicine Meets Regenerative Medicine p. 36 Signal Transduction in Regeneration p. 37 12:30–01:00 pm 01:00–02:30 pm LUNCH BREAK Clinical Studies in Cell Therapy and Tissue Engineering p. 33 Tissue Engineering II p. 35 Space Medicine Meets Regenerative Medicine, continued p. 36 Imaging of Regeneration II p. 37 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 13 Thursday, October 18 2nd Fraunhofer Life Science Symposium Leipzig 2007 Thursday, October 18 11:00 am–12:15 pm Immunology and Vaccines in Veterinary Medicine Chair: S. Ulbert > keynote L. Hellmann Vaccination against IgE – a potential treatment strategy against canine atopic dermatitis Tissue Regeneration in Veterinary Medicine 12:15–1:00 pm THURSDAY > keynote G. Alber Triggering immune reactions by vaccination Lunch break 2:00–3:30 pm Tissue Engineering in Veterinary Medicine Chair: W. Brehm > keynote W. Brehm Equine mesenchymal stem cells for the treatment of tendinous lesions in the horse > keynote J. Hubbell Biomaterial scaffold approaches for morphogen delivery S. Giovannini Multilineage potential of equine blood-derived fibroblast-like cells W. Brehm Influence of co-culture on the formation of hyaline cartilage in vitro in a 3-D system with equine chondrocytes and autologous equine bone marrow mesenchymal stem cells 3:30–4:00 pm Coffee break R O O M 10 9:00–10:30 am Stem Cell Technology in Mammals Chair: A. Einspanier N. zur Nieden Primate embryonic stem cells > keynote N. Jeffery Intraspinal transplantation of olfactory ensheathing cells for severe spinal cord injury in the dog R. Revoltella Primate embryonic stem cells create their own niche while differentiating in threedimensional culture systems H. Gabr Stem cell therapy for acute spinal cord injury in dogs > keynote J. Plendl Vascular stem cells in the bovine ovary > keynote W. Kues Derivation of stem cells from farm animals and rodents: programming and reprogramming of somatic cells 10:30-11:00 am 14 4:00–5:30 pm Cell Therapy in Veterinary Medicine Chair: T. Flegel > keynote L. Behr Intra renal arterial administration of autologous mesenchymal stem cells (MSC) in an ovine model of ischemia reperfusion injury results in kidney engraftment by MSC without differentiation and functional or morphological improvement H. Thissen Micro arrays, stem cell-surface interactions and germ cell transplantation Coffee break 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 15 16 HALL 5 9:00 am–12:30 pm Thermo Fisher Scientific – Partner of Regenerative Medicine Research – Brunch Symposium THURSDAY G E T-T O G E T H E R I N T H E E X H I B I T I O N A R E A | P O S T E R S E S S I O N K.-G. Hoppmann Thermo Fisher Scientific – Competent Partner of Regenerative Medicine Research – Overview S. Scory Staying on target with siRNA: Using siRNA tools of optimized specificity for screening and for therapeutic approaches G. Kohla Mag(net)ic purification of DNA – principles of DNA purification using magnetic beads and the KingFisher W. Glück Perfection for safety – a new generation of Biological Safety Cabinets 10:45–11:00 am Coffee break A. Kamath The utility of multipotent cord blood unrestricted somatic cells E. Schwander Expansion of adherent mammalian cells - From research bench to industrial applications – A brief overview on disposable solutions and their use within therapeutic approaches * bioreactor presentation in session W. Glück Cell culture without compromise – How to minimize the risk of contamination in CO2Incubators 5:30–7:30 pm Stem Cells: Cardiac Symposium* ESAO – European Society of Artificial Organs Towards Bioartificial Organs New Industrial Technology Platform* 4:00– 5:30 pm 3:30–4:00 pm Cell Therapy in Veterinary Medicine COFFEE BREAK Symposium ISAC – International Society for Analytical Cytology Biophysics in Cell and Tissue Research Stem Cells in Diabetes Industry Technology: Industry Immunologic Tissue Acceptance Insights and Strategic Direction 2:00– 3:30 pm OPENING CEREMONY 1:00–2:00 pm 11:00 am– 12:30 pm Immunology and Vaccines in Veterinary Medicine Thermo Fisher Scientific – Partner of Regenerative Medicine Research – Brunch Symposium Tissue Engineering in Veterinary Medicine Bioengineering of Soft Tissue Membranes Thursday, October 18 Stem Cell and Tissue Bioengineering HALL 3 HALL 1 REGENERATE General Assembly of the European Network for Regenerative Medicine EEIG ( R O O M 9) HALL 4 R O O M 10 Stem Cell Technology in Mammals 9:00– 10:30 am OCTOBER 18, 2007 HALL 5 Symposium GRM – German Society for Regenerative Medicine e.V. Progenitor Cell Therapy, LLC – Industry Symposium Thursday, October 18 Overview 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E 2:00–3:30 pm Industry Technology: Industry Insights and Strategic Direction Chair: V. Ronfard > keynote D. Williams Regulated manufacturing of emerging cell and tissue based therapies M. Lysaght Recovery and growth of private-sector tissue engineering and regenerative medicine during the past five years Z. Aberman (Pluristem Life Systems, Inc.) Placental 3D mesenchymal stem cells – A source for regenerative medicine W. Rüdinger (Cytonet GmbH & Co. KG) Regulatory frame for cell therapeutic approaches in light of the German tissue law and the EU directives 3:30–4:00 pm Coffee break OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 17 Thursday, October 18 Thursday, October 18 HALL 5 3:30-4:00 pm > keynote V. Ronfard (Organogenesis Inc.) Development of collagen based biomaterials I. Otte-Höller (LEICA-Mikrosysteme Vertrieb GmbH) Laser microdissection – Applications of live cell cutting F. Ylera (AbD Serotec) Rapid generation of monoclonal antibodies using in vitro selection technology S. Arain (PreSens Precision Sensing GmbH) Non-invasive online-monitoring of oxygen and pH in cell cultivation T. Jones (Antitope Ltd.) Therapeutic antibodies without helper T cell epitopes HALL 4 9:00–10:30 am Why invest in an innovative field? Symposium organised by German Society for Regenerative Medicine (GRM e. V.) Chair: T. Skutella W. Brech Advanced Asset Management AG Deutschland, Frankfurt/Main F. Mettler GMF Beteiligungsberatungs GmbH, Frankfurt/ Main E. Lampeter Vita 34 AG, Leipzig 11:00 am–12:30 pm Progenitor Cell Therapy, LLC – Industry Symposium S. Craig Developing cell therapies for commercial success 2:00–3:30 pm Immunologic Tissue Acceptance Chairs: J. Lehmann, M. Seifert > keynote H. Waldmann Regulation and privilege in the long-term acceptance of allografts > keynote T. Gilbert The host response to biologic scaffold materials K. Kretschmer De novo generation of regulatory T cells and Foxp3-dependent gene regulation A. C. Zenclussen Treg-dependent tolerance mechanisms during murine pregnancy 18 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E 4:00–5:30 pm Towards Bioartificial Organs Symposium organised by the European Society for Artificial Organs (ESAO) Chairs: B. H. Walpoth, A. Bader D. Falkenhagen Cell Apheresis – present stage and future developments B. Glasmacher Cryopreservation of cell-seeded scaffolds M. H. J. Maathuis New machine perfusion technques for preservation and transportation of donor organs B. H. Walpoth Cellular remodelling of biodegradable vascular grafts A. Bader Preclinical and clinical results in bone/cartilage engineering with bioreactors THURSDAY 4:00–5:30 pm New Industrial Technology Platform Chairs: D. Williams, G. Schmiedeknecht Coffee break HALL 1 1:00–2:00 pm OPENING CEREMONY Welcome addresses > Frank Emmrich, Head of Fraunhofer Institute for Cell Therapy and Immunology > Bernat Soria Escoms, Minister of Health and Consumer Affairs of Spain > Klaus Theo Schröder, State Secretary from the German Federal Ministry Health and social security > Peter Lange, Head of Department of Research and Health from the German Federal Ministry of Education and Research G. MacKay (Organogenesis Inc.) > keynote Learning from the development of a cell-based business model 2:00–3:30 pm Stem Cells in Diabetes Chairs: G. Orive, B. Stratmann > keynote B. Soria Cell therapy of diabetes and its complications > keynote B. Stratmann Therapeutic potential of stem cells for ischemic wounds in diabetes mellitus > keynote Y. Reisner Embryonic pig pancreatic precursor tissue as a potential source for transplantation in type 1 diabetes 3:30–4:00 pm Coffee break OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 19 Thursday, October 18 Thursday, October 18 HALL 1 P. Linder, E. Kurulgan, A. Robitzki, G.M. Artmann HP Bioforce: High-throughput cell culturing for cell and tissue research A. Pfützner Differentiation of adipocyte-derived adult mesenchymal stem cells into insulin expressing cells in vitro K. Guan Spermatogonial stem cells for cardiac regeneration A. Linke Activation of cardiac progenitor cells by growth factors and exercise training J. Li ERa is expressed in cardiac stem cells and supports self-renewal after cardiac ischemic injury in rat H. Aupperle Injection of autologous mesenchymal bone-marrow derived stem cells in rabbits with chronic doxorubicin cardiomyopathy results in functional and histomorphological alterations of the cardiac extracellular matrix I. Digel, G. M. Artmann Protein dynamics in thermosensation K. F. Zerlin Temperature transitions in haemoglobin and other globular proteins A. Stadler, I. Digel, G.M. Artmann, G. Büldt, J. Zaccai Dynamics and interactions of haemoglobin in human red blood cells and concentrated haemoglobin solutions P. Kleinbongard RBC NO-synthase and its effects in cell function and cell-cell interaction HALL 3 9:00–10:30 am Bioengineering of Soft Tissue Membranes Chairs: M. Staat, G. Hüttmann M. Valter, A. Temiz Artmann Differential overexpression of MMP-9 and mechanical inhomogeneity of the chorioamniotic sac during premature rupture of the membranes M. Staat, M. Topcu, S. Sponagel Mechanical modelling and testing of biological membranes M. Kemmerich, G. Antweiler, A. Temiz Artmann, P. Linder Mechanics and structure of amniotic sac tissue as potential information to predict premature birth G. Hüttmann Optical coherence tomography and its applications in biotechnology and regenerative medicine J. Trzewik, P. Meier The changing nature of medical product development through “Open Innovation” 11:00 am–12:30 pm Stem Cell and Tissue Bioengineering Chairs: J. Hescheler, P. Lelkes E. Tobiasch The differentiation potential of human mesenchymal stem cells J. Hescheler Embryonic stem cells for bioengineering in regenerative medicine P. I. Lelkes, M. J. Mondrinos, S. Koutzak, C.M. Finck Engineering of vascularized distal pulmonary tissue constructs in vitro and in vivo 20 2:00–3:30 pm Biophysics in Cell and Tissue Research Chairs: G. M. Artmann, G. Dikta THURSDAY 4:00–5:30 pm Stem Cells: Cardiac Chairs: G. Steinhoff, J. Li 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E G. Dikta Statistical change-point analysis 3:30–4:00 pm Coffee break 4:00–5:30 pm Cytometry – A Key Technology in Regenerative Medicine Symposium organised by the International Society for Analytical Cytology (ISAC) Chair: R. F. Murphy R. F. Murphy Identifying subtle changes in cell phenotypes using automated microscopy and machine learning: Implications for Regenerative Medicine J. Szöllösi Biophysics of ErbB2 signaling R. M. Zucker Morphology and apoptosis in thick tissues using a confocal microscopy A. Tárnok Cytomics for regenerative medicine OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 21 22 Friday, October 19 8:30–10:30 am Stem Cells: Emerging Developments Chairs: D. Hutmacher, A. Stolzing > keynote Y. Barrandon Potential of squamus epithelial cells in regenerative medicine R. L. Bartel (Aastrom Biosciences) Autologous stem cell therapies: Human clinical experience H. J. Meisel Nucleus pulposus regeneration using fresh autologous adipose-derived cells FRIDAY S O C I A L E V E N I N G AT M O R I T Z B A S T E I G. Thumann Tissue-engineered biodegradable pigment epithelial cell sheets for transplantation to the subretinal space R. Revoltella Human CB-CD.133+ cells injected into NOD-SCID mice made deaf after ototoxic treatment provide cenditions for the resumption of the inner ear structure and function A. Hartmann Stem cell markers of the human hair follicle- characterization of a tissue engineered reconstruct based on plucked hairs compared to human scalp 10:30–11:00 am Coffee break * bioreactor presentation in session 11:00 am–12:30 pm Law of hESC Research, Reimbursement, Ethics, and Advanced Therapy Products Chair: S. Schilling, E. Falkner > keynote C. Mason Regenerative Medicine 2.0: No longer lost in translation D. Bühler (Maiwald Patentanwalts GmbH) Patenting of stem cells in Europe Y. Joly Open approaches in regenerative medicine N. K. Hafezi Maximizing resources and assessing fundraising potential to sustain research centers 12:30–1:30 pm Lunch break 8:00 pm Imaging of Regeneration I Immunologic Issues in Regenerative Medicine Regulatory Affairs in Advanced Therapy Products 5:00– 6:30 pm Innovative Methods and Drug Delivery Technologies Stem Cells: Liver* Symposium ETCS – European Tissue Culture Society Stem Cells and Tumorigenesis Pluristem Life Systems, Inc. Placental Cells in Cell Therapy Industry Symposium Pluripotency and Gamete Derived Stem Cells 3:30– 5:00 pm COFFEE BREAK 3:00–3:30 pm Tissue Engineering I* Symposium ESOT – European Society for Organ Transplantation Stem Cell Transplantation and Immunomodulation HALL 1 Embryonic Stem Cells 1:30– 3:00 pm 12:30–1:30 pm LUNCH BREAK NanoMicrostructures in Diagnostics, Therapy and Therapeutic Monitoring: Neuroperspectives NanoMicrostructures in Diagnostics, Therapy and Therapeutic Monitoring Metabolism in Regenerative Medicine Biomaterials and Scaffolds for Regeneration I Law for hESC Research, Reimbursment, Ethics and Advanced Therapy Products 11:00 am– 12:30 pm 10:30–11:00 am COFFEE BREAK Cartilage and Bone Engineering Stem Cells: Emerging Developments Stem Cells: Neuronal HALL 5 HALL 4 Vascular Remodelling and Angiogenesis* HALL 1 8:30– 10:30 am O C T O B E R 19, 2 0 0 7 HALL 3 Friday, October 19 Overview 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 23 Friday, October 19 Friday, October 19 HALL 1 HALL 4 1:30–3:00 pm Embryonic Stem Cells Chairs: C. Mason, S. Trkov 8:30–10:30 am Vascular Remodelling and Angiogenesis Chairs: A. Mol, M. Stekelenburg M. Rao (Invitrogen Corporation) > keynote ESC and embryotoxicity assays > keynote H. Mertsching Engineering of vascularised tissues: State of the art C. Lerch Legal framework for human embryonic stem cell research in Europe and Germany and its implications for regenerative medicine J. Razavi Regulation of galanin in human embryos and human embryonic stem cells 3:00–3:30 pm Coffee break 3:30–5:00 pm Pluripotency and Gamete Derived Stem Cells Chairs: J. Hescheler, P. Bareiss > keynote W. Engel Pluripotent stem cells from adult testis T. Skutella Spermatogonial stem cells from adult human testis and the generation of pluripotency in vitro and in vivo S. Danner Derivation of oocyte-like cells from a clonal pancreatic stem cell line C. Busch Embryonic stem cells in human sacrococcygeal teratomas: Isolation and characterization of an embryonic stem cell line 5:00–6:30 pm Regulatory Affairs in Advanced Therapy Products Chairs: H. Mertsching, M. Braun > keynote B. Sickmüller Advanced therapies: State of discussions in Germany and the EU > keynote K. Cichutek Regulatory aspects of advanced therapy medicinal products > keynote R. A. Lang Macrophages regulate vascularization using the Wnt pathway: Implications for tissue regeneration C. Gentile Bioengineering lumenized blood vessel-like tissue spheroids from adult human cells J. Frese Bioreactor development for capillary network formation in fibrin gel FRIDAY > keynote J. Hescheler Embryonic stem cells and regenerative medicine T. Egana Use of immortalized mesenchimal cells to induce in vivo angiogenesis during matrix based dermal regeneration. J. Trommer Construction of small diameter vascular grafts based on decellularized matrices seeded with aortic endothelial cells in a pulsatile flow bioreactor 10:30–11:00 am Coffee break 11:00 am–12:30 pm Metabolism in Regenerative Medicine Chairs: D. Falkenhagen, P. Ahnert > keynote E. Holmes The role of metabolic profiling in regenerative medicine > keynote M. Cross Metabolic considerations in stem cell culture E. Volkmer 3D-culture-associated central hypoxia accounts for quality gradients of engineered tissues L. Buravkova Rat bone marrow-derived mesenchymal stromal progenitor cells under anoxia 12:30–1:30 pm Lunch break S. Sethe Informed consent in tissue banking U. Hoffmueller (Epiontis GmbH) Quality control of autologous cell therapy based on DNA methylation markers 24 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 25 Friday, October 19 HALL 4 HALL 5 1:30–3:00 pm Tissue Engineering I Chairs: N. Jeffrey, A. L. Rosa > keynote D. W. Hutmacher Comparison of mesencymal precursor cells from bone marrow and adipose tissue from a tissue engineering perspective > keynote A. Mol Heart valve tissue engineering: Current status and future prospects M. Wöltje Bone marrow or fat for soft tissue engineering: Comparison of preadipocytes and mesenchymal stromal cells after adipogenic differentiation in vitro A. Ovsianikov 3D hybrid polymeric scaffolds for tissue engineering 8:30–10:30 am Cartilage and Bone Engineering Chairs: N. zur Nieden, M. T. Raimondi > keynote F. Rustichelli Advanced applications of X-ray synchrotron radiation in bone and muscle regenerative medicine research B. Kalpakcioglu The interrelation of free radicals in osteoarthritis S. M. Cool Bone formation in a critical-size rat calvarial defect is enhanced by heparan sulfate J. Weisser Development of a biphasic matrix for osteochondral defects W.-Y. Lin The effects of chinese herbal medicine on chondrocytes for cartilage tissue engineering 3:00–3:30 pm Coffee break 3:30–5:00 pm Stem Cells and Tumorigenesis Symposium organised by the European Tissue Culture Society (ETCS) Chair: A. M. Wobus A. Trumpp The role of Myc genes in stem cells during development, homeostasis and disease F. Rosenbauer Transcription factors and tumor stem cells M. Wartenberg ES-derived in vitro models for cancer research 5:00–6:30 pm Placental Cells in Cell Therapy Symposium organised by Pluristem Life Systems, Inc. Chair: Z. Aberman E. M. Horwitz Novel insights into MSC therapy of bone disorders A. Kaduri The gap between the advanced basic research of stem cells and its industrial therapeutic applications A. Toren Novel allogeneic cell therapy using PLX-I, a placental derived mesenchymal stromal cell, grown in a 3D culture 26 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E FRIDAY Friday, October 19 G. Schmidmaier Mechanical stimulation affects osteoblast and osteoclast like cells G. Gross Strategies for regenerative mesenchymal stem cell therapies of skeletal disorders: Pathways to tendon formation - Targeting of MSCs to cartilage tissues 10:30–11:00 am Coffee break 11:00 am–12:30 pm Biomaterials and Scaffolds for Regeneration I Chairs: C. Semino, Y. Ibold > keynote M. Hofmann Viability testing of bio-artificial tissue > keynote G. Orive Therapeutic applications of cell encapsulation D. W. Hutmacher Evaluation of 2-year calvarial reconstruction with polycaprolactone and polycaprolactone-based scaffolds in a rabbit model R. Schade Hydrostatic stimulation of chondrocytes on collagen I/III scaffolds 12:30–1:30 pm Lunch break OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 27 Friday, October 19 Friday, October 19 HALL 5 R. Dressel The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal precursor cells depends on the recipients’ immune response H. Schlitt Current concepts of immunosuppression in allogeneic transplantation HALL 3 L. Piemonte Islet transplantation and stem cell cotransplantation 8:30–10:30 am Stem Cells: Neuronal Chairs: T. Skutella, M. Metzger J. Sowden Retinal repair by transplantation of photoreceptor precursors R. Poulsom Cell therapy for renal repair: Where are we now? 3:00–3:30 pm Coffee break 3:30–5:00 pm Stem Cells: Liver Chairs: M. Alison, S. Salerno > keynote D. Kerr Neurodegeneration and regeneration in the nervous system > keynote E. Sykova Stem cells, biomaterials and nanotechnology for treatment of spinal cord injury > keynote F. Emmrich Stem cell therapy in stroke N. Weidner Adult neural progenitor cells for spinal cord repair > keynote J. Gerlach Bioreactor technology for liver progenitor cell-based therapy > keynote J. G. Hengstler Liver regeneration after intoxication with CCl4: spacial-temporal mathematical modelling in triple transgenic mice reveals the relevance of communication between hepatocytes and sinusoidal lining cells U. Gehling Mobilization of unique populations of haematopoietic progenitor cells in response to clinical situations associated with liver regeneration. B. Christ Differentiation of human adipose tissue derived mesenchymal stem cells to hepatocyte-like cells in vitro and in vivo 5:00–6:30 pm Immunologic Issues in Regenerative Medicine Chairs: F. Emmrich, M. Schmitz > keynote A. Kurtz Adoptive T-cell therapy to regenerate from chronic virus induced tissue-remodelling S. Mitzner Extracorporeal immune cell support for the treatment of bacterial sepsis T. Ritter Down-regulation of MHC class I protects mesenchymal stem cells against T-cell mediated cytotoxicity in an inflammatory surrounding 28 J. Ladhoff Endothelial derivatives of rat embryonic stem cells are less immunogenic in an allogeneic setting FRIDAY 1:30–3:00 pm Stem Cell Transplantation and Immunomodulation Symposium organised by the European Society for Organ Transplantation (ESOT) Chair: M. Alison 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E M. Skardelly A longterm evaluation of the potency of a specific cellular transplantation procedure as a therapeutic strategy after traumatic brain injury 10:30–11:00 am Coffee break 11:00 am–12:30 pm NanoMicrostructures in Diagnostics, Therapy and Therapeutical Monitoring Symposium organised by the Deutsche Gesellschaft für Biomedizinische Technik (DGBMT/VDE) and the Center for Biotechnology and Biomedicine (BBZ) Leipzig Chairs: A. Robitzki, A. Rothermel J. M. Cooper Lab-on-a-chip technologies for diagnostics and cell analysis A. Agarwal Silicon nanowire sensors for label-free real-time diagnostics J. Wegener Nanoporous silicon surfaces as a novel tool to visualize the barrier characteristics of 2D tissues U. F. Keyser Solid-state nanopores for understanding polymer transport in living cells 12:30–1:30 pm Lunch break OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 29 HALL 3 1:30–3:00 pm NanoMicrostructures in Diagnostics, Therapy and Therapeutical Monitoring: Neuroperspectives Symposium organised by the Deutsche Gesellschaft für Biomedizinische Technik (DGBMT/VDE) and the Center for Biotechnology and Biomedicine (BBZ) Leipzig Chairs: A. Robitzki, A. Rothermel T. Stieglitz Intelligent implants – A progress report on neuroprostheses T. Arendt Neuronal cells of Alzheimer brains are similar to tumour cells – progress in therapeutic approaches B. Schlosshauer Tissue engineering of peripheral nerves J. Boltze Preclinical evaluation of autologous bone marrow cell therapy for stroke in a large animal model C. Emerson Ethical issues in neuro-regenerative medicine: International perspectives 3:00–3:30 pm WE MAKE YOUR CONFERENCE A SUCCESS TO REMEMBER. CONFERENCES. MEETINGS. EVENTS. EVENT LAB. Comprehensive Concept Development Location Scouting Reliable Budgeting Personalised Participants Servicing Complete Conference Materials Class A Evening Programmes Effective Sponsoring Coffee break 3:30–5:00 pm Innovative Methods and Drug Delivery Technologies Chairs: A. Beck-Sickinger, J. Schmitz > keynote D. Anderson Combinatorial development of biomaterials for tissue engineering and drug delivery Y. Choo (Plasticell Ltd) Stem cell differentiation using multiplexed combinatorial cell culture experiments J. Park BMP-2 gene delivery using a liposomal vector with bone grafts in peri-implant bone defects on pig calvariae P. Schwabe The effect of non-viral delivery of BMP-2 plasmids with a copolymer protected gene vector (coprog) incorporated in a poly(d,l-lactide) coating on fracture healing C. Wiesner Implementation of cell-based test systems for the characterization of potential therapeutic drugs 5:00–6:30 pm Imaging of Regeneration I Chairs: H. Barthel, S. Vaga > keynote R. Graf Imaging the dynamics of spreading depression in the ischemic penumbra > keynote M. Hájek MR visualization of pancreatic islets transplantation by SPIO based contrast agents T. Schmidt Live imaging of mechanical stressed cells N. Raschzok Transplantation of primary human hepatocytes – Iron oxide labelling for cell detection via MRI 30 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E event lab. Klein & Störmer GbR Address Telephone Fax eMail Talstraße 30, D-04103 Leipzig ++49 (3 41) 401 19 36 ++49 (3 41) 479 17 80 [email protected] www.eventlab.org OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY event lab. 31 Saturday, October 20 Imaging of Regeneration II T. Gingeras (Affymetrix, Inc.) Genome-wide maps of the human transcriptome reveal an interleaved organization and novel short and long classes of RNAs G. Verhaegh PCA3 – A non-coding RNA involved in prostate carcinogenesis Space Medicine Meets Regenerative Medicine, continued 10:00–11:00 am 11:00 am–12:30 pm Medical Applications of ncRNA, continued Chair: P. Stadler J. Vogel Small noncoding RNAs of bacterial pathogens SATURDAY N. C. Meisner mRNA Openers – Designed oligonucleotides for posttranscriptional upregulation of target gene expression 12:30–1:00 pm Lunch break 1:00–2:30 pm Clinical Studies in Cell Therapy and Tissue Engineering Chairs: T. Hoell, H. Fiegel > keynote J. Libera EuroDisc Study – assessment of efficacy and safety of sequestrectomy plus autologous disc chondrocytes – second interims analysis * bioreactor presentation in session Clinical Studies in Cell Therapy and Tissue Engineering Coffee break | Poster session | Poster award C. Schimmelpfennig Cellular therapy with cytokine induced killer cells (CIK cells) in patients with solid tumors O. Smikodub Embryonic stem cells in duchenne muscular dystrophy H. Gabr Stem cell transplantation for liver failure: Impact on liver function and quality of life M. Klentze Proteomics, PET and early detection of prostate cancer 01:00– 02:30 pm 12:30–01:00 pm 11:00 am– 12:30 pm 8:30–10:00 am Medical Applications of ncRNA Chair: P. Stadler Tissue Engineering II* LUNCH BREAK Materials, Surfaces and Implants* Space Medicine Meets Regenerative Medicine Signal Transduction in Regeneration ROOM 11 Medical Applications of ncRNA, continued C O F F E E B R E A K | P O S T E R S E S S I O N | P O S T E R AWA R D Neurodegeneration and Repair 10:00–11:00 am HALL 1 Symposium Biomaterials and Scaffolds for ICRS – International Cartilage Repair Regeneration II* Society How to Reconstruct Injured Cartilage? HALL 4 ROOM 11 Medical Applications of ncRNA OCTOBER 20, 2007 32 8:30– 10:00 am HALL 5 Saturday, October 20 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 33 Saturday, October 20 Saturday, October 20 HALL 4 1:00–2:30 pm Tissue Engineering II Chairs: T. Gilbert, B. Frerich M. Brittberg Chondrogeneic cells for cartilage repair: Basic and clinical aspects W. Kafienah Cartilage repair using stem cells: A pharmacological approach L. B. Creemers Aspects on cartilage regeneration and repair and future ideas 10:00–11:00 am Coffee break | Poster session | Poster award T. Drewa Bladder acellular matrix seeded with hair follicle epithelial cells for urinary bladder wall reconstruction – An animal study M. Stiehler Effect of 3-D dynamic culture on proliferation, distribution and osteogenic differentiation of mesenchymal stem cells B. Tschoeke Tissue-engineered vascular graft based on a fibrin PLA scaffold K.-H. Schuckert Bone tissue engineering in humans using scaffolds, growth factors and PRP 11:00 am–12:30 pm Materials, Surfaces and Implants Chairs: B. Rauschenbach, V. Kordium HALL 1 > keynote A. Heilmann Implant and cell culture characterization by Scanning Electron Microscopy (SEM) and Focused Ion Beam Technology (FIB) 8:30–10:00 am Biomaterials and Scaffolds for Regeneration II Chair: I. Grunwald I. Heschel Tailoring three-dimensional collagen scaffolds with interconnected orientated pores for potential applications in regenerative medicine > keynote C. Semino Cellular-self organization could be promoted by material microenvironment T. Habijan The surface properties of powder metallurgically fabricated Nickel-Titanium Shape Memory Alloys influence human multipotent mesenchymal stem cells‘ adhesion and proliferation K. Kratz Biodegradation studies of aliphatic polyesters using the Langmuir monolayer technique J. C. Ionita The use of biotechnological modified bone substitute materials in critical size defect model in pigs 12:30–1:00 pm 34 Keynote lecture, tba SATURDAY 8:30–10:00 am How to reconstruct injured cartilage? Symposium organised by the International Cartilage Repair Society (ICRS) Chair: M. Brittberg W. L. Neeley A microfabricated poly(glycerol-sebacate) scaffold for retinal progenitor cell grafting H. S. Koh Modification of polymeric nanofibrous scaffolds with ECM bioactive molecules to improve nerve regeneration K. Luetzow Loading of scaffolds with small molecules by integrated processes O. Castano Novel modified in-vivo casting for a Na-K doped calcium phosphate cement 10:00–11:00 am Coffee break | Poster session | Poster award Lunch break 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 35 Saturday, October 20 11:00 am–12:30 pm Space Medicine meets Regenerative Medicine J. Cornier Opening H.-C. Gunga Space Medicine – General Overview O. Ullrich Cellular and molecular mechanisms of disturbed immune cells function in microgravity D. Jones Bioreactors for studying mammalian tissues in microgravity H. van Beusekom Cardiovascular regenerative research and microgravity 12:30–1:00 pm Lunch break 1:00–2:30 pm Space Medicine meets Regenerative Medicine 11:00 am–12:30 pm Signal Transduction in Regeneration Chairs: tba, B. Wildemann > keynote E. M. Tanaka Limb regeneration and the multipotency of progenitor cells S. Richardson Differentiation of human mesenchymal stem cells to nucleus pulposus cells in type I collagen gels: Implications for tissue engineering of the intervertebral disc N. zur Nieden Steering embryonic stem cell fate towards osteoblasts with downstream noncanonical wnt targets in vitro K. Andreas Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro study H.-J. Stark Long-term skin equivalents in vitro and integrity of their epidermal stem cell niche 12:30–1:00 pm Lunch break G. Reitz Radiation risks in manned long term and interplanetary missions 1:00–2:30 pm Imaging of Regeneration II Chairs: C. Zilch, T. Schmidt J. Kempf ASTROHAB – A tool for extending human presence in space and understanding environmental effects on biological processes and pathology > keynote P. Walczak MR imaging and cell tracking in regenerative medicine Panel Discussion J. Cornier Closing > M. Hofmann PET for stem cell labeling SATURDAY HALL 1 keynote > keynote H. Barthel New developments in PET imaging of stroke and stroke therapies HALL 5 8:30–10:00 am Neurodegeneration and Repair Chairs: E. Sykova, U. J. Kang > keynote K.-S. Kim Novel therapeutic approaches for Parkinson‘s disease > keynote P. A. Calabresi Neuroprotective strategies in Multiple Sclerosis M.-O. Baradez (ReNeuron Group pl) Characterisation of REN005, a human neural stem cell derived from fetal striatum for Huntington‘s disease therapy A. Bozkurt Neural tissue engineering using microstructured orientated collagen scaffolds 10:00–11:00 am 36 Coffee break | Poster session | Poster award 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 37 Poster exhibition Scientific Session Tracking: Color Code ORANGE: Metabolism and signalling Posters PP001 A. G. Abarrategi Rhbmp-2/chitosan fi lm as titanium implant coating: in vitro characterization and in vivo bone formation. PP002 M. Ackermann Long-term multilineage engraftment of human cells in nod/scid mice YELLOW: Immunology PP003 M. Aliev Infl uence of surgical stress on cd34+ cell circulation and cytokine production that modulate biological activity of the hematopoietic stem cells (hsc). DARK GREEN: Materials, surfaces and implants PP004 M. Arsalan Human cardiac stem cells – there is a pool of autologous resident c-kit+ progenitors in the left and right atrium LIGHT GREEN: Biomaterials and scaff olds PP005 J. Azman Reg i expression in regenerating skeletal muscle in rat LIGHT BLUE: Tissue engineering PP006 H.-J. Bühring Monoclonal antibodies 39d5 and w8b2 defi ne distinct msc subsets in human bone marrow PP007 P. Büttner Human SGBS cells are a valid model for human adipocyte diff erentiation MEDIUM BLUE: Tissue engineering – vascular remodelling and angiogenesis PP008 D. Back Local application of Zoledronic acid from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats DARK BLUE: Cartilage and bone engineering PP009 P. Baer Conditioned medium from renal epithelial cells induces epithelial diff erentiation of human mesenchymal stem cells LIGHT PURPLE: Stem cells VIOLET: Neuronal stem cells DARK PINK: Imaging, cytometry PINK: Diagnostics, drug delivery, biomechanics, quality control and nanotechnology GREY: Industry, regulatory issues and others PP010 S. Bardelli Adipose tissue as a source of stem cells for regenerative medicine PP011 P. Bareiss Characterisation of human epithelial stem and progenitor cells from intestinal mucosa PP012 C. M. Bellini Posterior interspinous dynamic stabilization of the lumbar spine: a biomechanical study PP013 K. Bellmann Intelligent Modifi cation of Regenerative Chemokines to Improve Pharmacokinetic Properties PP014 M. M. Beloti Use of a novel membrane of Poly(vinylidene-trifl uoroethylene)/Barium titanate for guided bone regeneration PP015 K. S. Blum Eff ects of autotransplanted lymph node fragments on lymph vessel regeneration in minipigs PP016 K. Boehnke Epidermal Homeostasis and Extracellular Matrix Production in Long-Term Skin Equivalents PP017 C. Boran Study of recombinant protein tat-op1 in the osteogenic diff erentiation PP018 D. Horna Tomas Development of porous elastomers scaff old for tissue engineering applications PP019 N. Marí-Buyé Engineering a new functionalized hydrogel nanofi lm to study cellular behavior PP020 O. Castano (oral) Novel modifi ed in-vivo casting for a Na-K doped calcium phosphate cement. PP021 H. C. Colley Maintenance of mesenchymal stem cell phenotype by culturing on fi brin gels PP022 R. Cowie Eff ect of high frequency, low amplitude vibration on mesenchymal stem cells PP023 M. Cox The relationship between local mechanical environment and fi ber architecture and mechanical properties of engineered cardiovascular tissues 38 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 39 Posters Posters PP024 A. Díaz-Cuenca Chondrocyte cell-seeded collagen-ceramic composites for soft tissue grafts applications PP047 B. Frerich Quantitative evaluation of adipose tissue engineering in SCID mice PP025 S. Danti Poly(Propylene Fumarate)-based scaff olds for middle ear ossicle replacements: the eff ect of pregenerated ECM on the osteoblastic diff erentiation of human MSCs. PP048 S. Fricke A humanised triple transgenic mouse model: Induction of acute GvHD and the eff ects of X-Rays and chemotherapy on haematopoiesis PP026 L. Dao Fusion mediated regeneration of cells using adult stem cells PP049 F. Galbusera Cell population dynamics and oxygen transport in engineered tissue: a coupled Lattice Boltzmann – cellular automata model PP027 R. di Liddo 3D model of human preadipocyte culture based on self-assembling peptide nanofi ber PP028 R. Di Liddo Enzymatic and biological activity of angiogenin and its tryptic peptides PP029 A. G. Dias Eff ect of plasma-rich in growth fcators (prgf) on behaviour of mg63 osteoblasts; preliminary results PP051 J. Garbade There are global reverse remodelling eff ects of bone-marrow derived stem cells after right heart application in non-ischemic heart failure PP030 M.-T. Dieterlen Generation of insulin-producing neurons from human neural stem cells PP052 S. Geißler The impact of donor age on functional behaviour and proteomic make up of mesenchymal stem cells PP031 S. Dietz Stem cell based bone graft design using a perfusion and rotation system PP053 M. C. Gioviale Isolation and colture of β-like cells from porcine wirsung duct PP032 L. Dreesmann Angiogenic gelatin implant material PP054 J. D. Glaeser Modulaton of matrix metalloprotease activity in mesenchymal stem cells by variation of cycliccompressive loading PP033 L. Dreesmann Gelatin-based nerve conduit PP034 K. Dunker C-type lectins and the regulation of the immune system PP055 C. Goepfert Evaluation of in vitro-Cartilage Using Biochemical Parameters and Histological Grading Systems PP035 L. Dyakonov The skin cells culture is a perspective source of stem cells PP056 F. Grandi Skeletal muscle regeneration: evaluation of an experimental model by rt-pcr and cellular distribution. PP036 L. Dyakonov A comparative analysis of osteogenic diff erentiation of human bone marrow and adipose tissue multipotent mesenchymal stromal cells at level of the gene-markers expression PP057 C. Grandi Structural and biological comparison of rnase-a, rnase-4 and angiogenin-1 as therapeutical proteins PP037 C. Eder The HET-CAM Test: A rapid, cheap and simple model for pre-assessment of biocompatibility in tissue engineering research PP058 O. Grinakovskaya Permanent cultivation of human adipose tissue-derived mesenchymal stromal progenitor cells under hypoxia PP038 N. A. Elkhafi f A comparison between ex vivo expansion of umbilical cord blood stem cells with and without enrichment procedures PP059 U. Großmann Semi-automated radiosynthesis and in vitro testing of [18F]fl uoroetanidazole as a new surrogate marker for PET imaging of stem cell therapy in stroke Supported by the Translation Centre for Regenerative Medicine of the University of Leipzig, Germany (project no. 1095MN) PP039 A. Faikrua The eff ect of chitosan’s sources on the physicochemical properties of collagen/chitosan matrix PP040 E. Falkner Health technology assessment for tissue engineering:quality control & risk/ benefi t/ cost –analysis PP041 T. Felka Eff ects of Nitrosative Stress on the Metabolism of MSC PP042 T. Fernández A synthetic nanofi ber 3d-matrix allows mouse embryonic fi broblasts to diff erentiate into mesodermal lineages PP043 F. Feyerabend In vitro corrosion and cytocompatibility of two magensium alloys PP044 C. Fieber Isolation and Characterisation of Human Melanocytes for Clinical Use PP045 H. C. Fiegel Passaging of different hepatic cell types isolated from fetal rat liver permits mass expansion PP046 C. Heine Characterization of the fi bre outgrowth in organotypic dopaminergic slice co-cultures 40 PP050 G. Gallego Ferrer In vivo response of methacrylate-endcapped caprolactone scaff olds 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E PP060 J. Guerra Xenogeneic infection risk and restriction of individual rights: An European approach (EU, German, Spanish and English Law) PP061 A. Hartmann Fibrin promotes matrix remodelling, active vessel and basal membrane formation in a 3D 3-cellular in vitro skin reconstruct PP062 A. Höß Nanoporous Aluminum Oxide for Cell Culture Applications PP063 S. Höhle Monitoring of ECM production in artifi cial cartilage constructs by MALDI TOF mass spectrometry and 13C NMR spectroscopy PP064 S. Höhme Liver regeneration after intoxication with ccl4: spatial-temporal mathematical modelling in triple transgenic mice PP065 M. Haberhauer Tissue Engineering of Cartilage - Allogenous Plasma and Whole Blood Nanoscaff olds OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 41 Posters Posters PP066 E. M. Haddouti Isolation and diff erentiation potential of human dental follicle stem cells PP067 E. Hadjipanayi Modelling Fluid Kinetics during Plastic Compression of Collagen Scaff olds PP068 M. Hampel In vitro three dimensional trachea model PP069 S. Hau Neuronal hypoxia in vitro: expression of cell adhesion molecules and eff ects on migration of mononuclear cells PP070 X. He Roles of Sphingosine-1-phosphate and sphingosine kinase inhibitors in stem cell proliferation and diff erentiation PP071 A. Leal-Egana Determination of the cell/aggregate growth profi le inside alginate capsules PP072 A. Heilmann Investigations with Scanning Electron Microscopy (SEM) and Focused Ion Beam (FIB) on cartilage tissues PP073 S. Heinrich Reduced corrosion rates and REDUCED metal ION release of stainless steel after surface treatment with energetic ions PP074 A. Hejcl Hydrolytically degradable hydrogels in experimental spinal cord injury PP075 S. Henning Morphology, micromechanical mechanisms and mechanical properties of a resorbable nanocomposite material for bone regeneration PP076 P. Hepp Matrix-associated autologous chondrocyte transplantation (MACT) alone is not suitable for deep chronical osteochondral defects – an in vivo study in sheep PP077 C. Hohaus The use of bone morphogenetic protein-2 for lumbar spinal fusion PP078 H. Holland Interphase- Fluorescence in situ Hybridization- technique for detecting human stem cells in frozen xenogeneic tissue PP079 I. Iandiev Regeneration of retinal tissue – clearance of edema by triamcinolone ACETONIDE PP080 Y. Ibold Expansion of primary bone marrow-derived mesenchymal stem cells on microcarriers PP081 L. Jahangiri Mesothelial stem/progenitor cells of the peritoneumClonal characterization, Isolation and differentiation PP082 P. Jendelova Modifi ed iron oxide nanoparticles for in vivo cell imaging PP083 S. Jopp Bone tissue engineering using pcl-scaff old, rhbmp-2 and prp PP084 J. Kajahn Human pancreatic stem cells cultured on biodegradable meshes may serve as a myocardial patch for regeneration of infarcted tissue PP085 M. Keil Gene transfection methods in cord blood derived cd34+ stem cells for in vivo imaging in nod/scid mice PP086 K. Kendziorra Eff ect of progenitor cells on myocardial perfusion and glucose metabolism – investigated by nuclear medicine techniques. 42 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E PP087 F. Kießling The cd4 molecule as target of preliminary tests for induction of immunological tolerance in the triple-trangenic mouse model (cd4/dr3) PP088 J. Kim Osteogenic diff erentiation of human mesenchymal stem cells in bone morphogenic protein-2 incorporated hyaluronic acid based hydrogels PP089 A. Kinasiewicz Modifi cation of hepatocytes culture by glycosaminoglycans for bioartifi cial liver. PP090 A. Kinasiewicz Alginate-collagen microbeads for cell culture and bioreactor. PP091 F. Knöspel Optimisation of chemically defi ned culture media for murine embryonic stem cells using factor screening design analysis PP092 J. Knauer Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells PP093 C. Knocke From stem cell research to regenerative medicine - physical parameters can make the diff erence PP094 L. Kock Determination of the role of integrin α5β1 in cartilaginous ecm gene expression by chondrocytes embedded in agarose gel, in response to dynamic compression PP095 V. Kordium The use of non-biodegradable matrixes for the implanted cells fate study PP096 J. Kosacka Cholesterol and apolipoproteinD (ApoD) enhance neurite outgrowth and synapse formation in dorsal root ganglia (DRG) cultures PP097 A. K. Kretzschmar Development of methods to unhide the multiple targets of miRNAs. PP098 S. Krueger Chondrocytes in vitro succeed in synthesising collagen type II containing extracellular matrix only by adding human serum to a suitable three-dimensional cell culture system PP099 R. Kurz NanoMicroImplants for Controlled Drug Delivery PP100 C. Lam Evaluation of Long-term In Vitro Degradation of Polycaprolactone and Polycaprolactone-based Scaff olds PP101 C. Lantzsch Stem cell based regeneration of the retina - retinospheres as model system PP102 M. Lehmann Comparison of diff erent 3D-cultivation systems to engineer human autologous in vitro cartilage-like tissue with focus on diff erentiation and viability PP103 P. Lesny Utilizing nonwoven nanofi ber materials as tissue replacements PP104 J. Li Angiotensin AT2 receptor mediates cardiac c-kit+ cell proliferation and supports survival of cardiomyocyte PP105 K Linke Development of a vascularised liver cell module PP106 Z.-M. Liu Layer-by-layer assembly of glycosaminoglycansonto poly (l-lactide) for tissue engineering applications PP107 A. Lochmann rhBMP-2 Delivery From Scaff olds And In Situ-forming Gels OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 43 Posters Posters PP108 K. Lorenz Vascularisation of dermal skin equivalents in vitro PP130 D. Peroni Stem molecular signature of adipose-derived mesenchymal stem cells PP109 J. Lutz Correlation between nitriding parameters of medical CoCr alloys and resulting hardness increase and reduction of wear rate PP131 PP110 J. Müller Npy receptors expression during retinogenesis PP111 K. Müller-Zahm Virus-like particles as gene transfer system for tissue engineering of cartilage PP112 K. Ma Modifi cation and characterization of blended nanofi ber substrates as skin grafts for the capture of bone-marrow derived hematopietic stem cells PP113 K. Mahbubani Preservation of cells for use in regenerative medicine PP114 K. Mahbubani Use of ph responsive polymers for a novel cancer treatment PP115 M. Mahmoodinia The role of wnt signaling in diff erentiation of cord blood unrestricted somatic stem cells into dopaminergic neurons PP116 D. Manova Corrosion rateS of Mg alloys PRODUCED BY PVD PrOCESSES and resulting ion concentrations in simulated body fl uid PP117 M. Mather In-process monitoring of foamed polymeric tissue scaff old fabrication PP118 H. J. Meisel EuroDISC Study – assessment of efficacy and safety of sequestrectomy plus autologous disc chondrocytes – second interims analysis PP119 M. Metzger Isolation and biological potential of enteric nervous system precursors derived from human gut PP120 J. Milosevic Extracellular nucleotides govern human neural precursor cell proliferation and dopaminergic diff erentiation PP121 A. Mittag A bead model for the realization of 3D Tissue Cytometry PP122 C. Nesti Neural stem cells cocultured with dental pulp stem cells preferentially diff erentiate into glial cells PP123 S. Neuss Stem cells and polymers for tissue engineering applications PP124 J. Ngoenkam The eff ect of blending starch into chitosan/β-glycerophosphate on thermoresponsive property PP125 M. Ngoenkam Modifi cation of biomaterials with layer-by-layer technique PP126 A. Niklas Trial design of remyelination trials in multiple sclerosis: Reproducibility of visual evoked responses PP127 H. Nitzsche Diff erent Strategies for Production and Characterisation of Hydroxyapatite loaded CollagenChitosan-Scaff olds PP128 A. Ovsianikov (oral) 3D hybrid polymeric scaff olds for tissue engineering PP129 J. Park Nano-scale microenvironment directs mesenchymal stem cell fate 44 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E S. Peter Large scale suspension culture of mesenchymal stem cells PP132 A. E. Petschnik Diff erentiation of human pancreatic adult stem cells into neuronal, glial and muscle cells PP133 D. Pollet Image analysis approach for the application of embryonic stem cell-derived myocards in pharmacological research PP134 I. Hanisch Acceleration of bone regeneration through application of erythropoetin PP135 L. Quintana Self assembly and reprogramming of dermal fi broblasts in a 3d nanofi ber SCAFFOLD PP136 M. T. Raimondi The eff ect of low regimens of interstitial perfusion on the development of engineered cartilage PP137 D. M. Reich Neuronal hypoxia: protective effects of mononuclear cell fractions after direct and indirect application PP138 C. Rentsch The osteogenic potential of embroidered polycaprolactone-co-lactide scaff olds coated with collagen i and chondroitin sulfate, seeded with human mesenchymal stem cells and implanted in a critical size femoral defect in rats PP139 R. Revoltella Selective growth and expansion of human corneal epithelial basal stem cells in a three-dimensional-organ culture PP140 R. Revoltella Three-dimensional organotypic cultures to investigate human conjunctival epithelial precursor cells and their progeny within their natural microenvironment PP141 R. Revoltella Selective Growth of Epithelial Basal Cells From Human Prostate in aThree-Dimensional Organ Culture PP142 S. Richardson Intervertebral disc regeneration using chitosan-glycerophosphate hydorogels and diff erentiated human mesenchyal stem cells PP143 M. Keller Three Dimensional Culture Model for Polarized Hepatocytes in a Bioreactor PP144 A. Leal-Egana Profi le of gfp release derived from transformed fetal hepatocytes in alginate microcapsules. PP145 A. Luiz Rosa Tissue engineering: in vivo bone response to the biomaterial obtained by seeding stem cells into porous CaP/PLGA scaff old PP146 M. Rostovskaya Clonal characterization of bone marrow mesenchymal stem cells using conditionally immortalized lines from tetracycline regulated sv40 large t-antigen transgenic mice. PP147 M. Rubbens Intermittent straining accelerates the development of tissue properties in engineered cardiovascular tissues PP148 T. Rupf Dynamic seeding of scaff olds improves fabrication of dermal layers in skin bioreactors PP149 S. Salerno Reconstruction of Human Liver Functions in Novel Polyetheretherketone-Polyurethane (PEEKWC-PU) Membrane Bioreactor OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 45 Posters Posters PP150 T. Sawada Erythropoietin and its derivative stimulate angiogenesis by bone marrow cells PP171 PP151 PP172 O. Smikodub Embryonic Stem Cell Transplantation in Multiple Sclerosis R. Schäfer The Use of Clinically Approved Small Particles of Iron Oxide (SPIO) for Labeling of clonal rat Mesenchymal Stem Cells Aggravates Clinical Symptoms in Experimental Autoimmune Encephalomyelits (EAE) PP173 O. Smikodub Embryonic Stem Cells in Rheumatoid Arthritis PP152 G. Schaarschmidt Overexpression of functional cation channels in neural stem cells PP174 O Smikodub Embryonic Stem Cells in Metabolic Syndrome PP153 N. Scherf An automatic analysis of cartilage regeneration in an model of human/murine scid arthritis PP175 O. Smikodub Embryonic Stem Cells in Insulin Resistance Decrease in Patients with Impaired Glucose Tolerance PP154 S. Schewtschik New culturing strategies to optimise functional neural development from midbrain derived neural precursors PP176 C. Stamm Mechanical stress facilitates coupling of skeletal myoblasts with cardiomyocytes PP155 E. Schilling Determination of cell-biological parameters of non-activated and activated (LPS) monocytes in response to diff erent synthetic soft materials under the infl uence of shear stress PP177 PP156 U. R. Schmidt Intravenous administration of Human Umbilical Cord Blood Cells after stroke in rats: investigation of the therapeutic time window regarding functional recovery PP178 C. Stamm Cryopreserved human bone marrow progenitor cells as a potential cell source for cardiovascular tissue engineering PP157 T. Schmidt (oral) Life imaging of mechanical stressed cells PP179 M. Stekelenburg From strong human tissue-engineered vascular grafts to an in-vivo porcine model PP158 M. Schmitz Mesenchymal stem cells effi ciently impair the immunostimulatory capacity of native human dendritic cells PP180 H. Stephan Development of a high content screening system for investigation of the infl uence of the extracellular matrix on adhesion and proliferation of human neural progenitor cells PP159 K. Schroeck Characterization of a new material for human mesenchymal stem cell-based bone tissue engineering PP181 PP160 R. Schulz Development of a bioreactor system for the regeneration of 3D cartilage-grafts PP161 G. Schulze-Tanzil Cell surface receptor expression for adenoviral cell entry is modulated by culture conditions in human articular chondrocytes C. Stamm Autologous bone marrow mononuclear cell implantation in lvad patients with end-stage nonischemic cardiomyopathy J. Stevens-Smith The eff ect of oxidative stress on bone formation in vivo PP182 M. Stiehler (oral) Eff ect of 3-D dynamic culture on proliferation, distribution and osteogenic diff erentiation of mesenchymal stem cells PP183 A. Stolzing Mesenchymal stem cells and bone fracture risk in diabetes mellitus PP162 S. Schwan Mechanical testing of a protein based scaff old made by three phase production process PP184 B. Stratmann Autologous tissue repair cells in the treatment of limb ischemia induced chronic ulcers of diabetic foot patients PP163 P. Schweizer Adhesion, proliferation and diff erentiation of primary human keratinocytes on chemically functionalized nano- and microstructured surfaces PP185 C.-Y. Su Concilletin-the advent of a new antiinfl ammatory agent- PP164 A. Scutt Eff ect of cannabinoids on mesenchymal tissues PP165 N. Scutt The eff ect of in vivo ageing on rat tendon cells PP186 C.-H. Su Application of chitin containing cell wall of fungi for acute and chronic wound therapy PP187 G. Tanasie In vitro growth of human mesenchymal stem cells seeded on 3d polymeric matrices PP166 K. Seifert Small molecules as agonists of hedgehog signaling and their use for wound healing PP188 A. R. Thomsen The role of oxygen tension in rediff erentiation of human articular chondrocytes - a fl ow cytometric study PP167 D. Seitz Glutaraldehyde-crosslinked chitosan scaff olds with adjusted mechanical properties and porosity as cartilage scaff olds for dynamic compression cultivation PP189 S. Trepke Retroviral vector design for stable cell transduction PP168 D. Seitz A biocompatible sensor-array instrument with rapid coupling mechanism for online-measurement of physiological data in cell cultures PP169 J. Shved Polylactide fi lms for substitutive cell therapy of skin PP170 M. Skardelly In vivo tracking of xfp expressing murine fetal neural stem cells by two photon laser scanning microscopy (2plm) after tbi 46 O. Smikodub Experience of Application of Embryonic Stem Cells (ESC) in Amyotrophic Lateral Sclerosis 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E PP190 S. Trettner Osteogenesis in primate embryonic stem cells PP191 S. Trkov Characterization of adherent clonogenic cells isolated from human umbilical vein PP192 L. Trombi Human autologous plasma derived clot as a biological scaff old for mesenchymal stem cells in treatment of orthopaedic healing OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 47 Posters Posters PP193 W.-B. Tsai Mechanical compression modulates the biochemical behavior of chondrocytes seeded in elastic chitosan/gelatin scaff olds PP194 E. Twerdowski Combined ultrasonic and confocal laser scanning microscopy of biological objects PP195 F. Ugarte Analysis of the role of Notch signaling in the cell fate determination of bone marrow human mesenchymal stem cells (hMSC). PP196 S. Vaga Delayed gadolinium-enhanced magnetic resonance imaging (dgemric) for the quantifi cation of glycosaminoglycans depletion and regeneration in human intervertebral discs PP197 P. Verma „Liver like“ three dimensional spheroids of human hepatocyte cell line on agar gelatin scaff olds for preliminary drugs and chemical toxicity PP213 K. Wiegandt Optimization of growth factor supplements for the generation of cartilage-carrier-constructs PP214 B. Wildemann Growth factor quantifi cation in diff erent bone graft materials PP215 E. Wunder Distribution patterns of cd34 antigen on cord blood progenitors PP216 N. Yudintseva Fibrin equivalent can be used for treatment diff erent etiology skin wounds. PP217 V. Zaporozhan Regenerative medicine: state in ukraine PP218 C. Zechel Infl uence of growth factor cocktails and growth matrices on proliferation and diff erentiation of stem cells from the adult mammalian brain PP198 V. Verma Human hair proteins: potential scaff old materials for tissue engineering PP219 A. Zhirkov The cellular therapy impact on bone tissue regeneration and psychological status of patients with mechanical injury PP199 J. Viyoch Keratinocyte growth factor receptor and keratin 4-14 expression in human keratinocyte growth on blending collagen/crab chitosan scaff old PP220 M. Zscharnack Increased chondrogenic diff erentiation of bone marrow derived MSCs after expansion in low oxygen tension. PP200 J. von der Ruhr Improved vascular regeneration and impeding of re-stenosis by Shikonin based stent coatings PP221 N. zur Nieden Enrichment of Mesenchymal Progenitors from Embryonic Stem Cells PP201 M. Vorobeychik Induction of pancreatic beta-cell phenotype in hepatic progenitor cells (hpc) isolated from adult diabetic mice. PP222 N. zur Nieden (oral) Steering embryonic stem cell fate towards osteoblasts with downstream non-canonical wnt targets in vitro PP202 B. Voss Homing and Diff erentiation of transplanted Bone Marrow Cells in Livers of Murine Schistosomiasis PP203 M. Wöltje (oral) Bone marrow or fat for soft tissue engineering: Comparison of preadipocytes and mesenchymal stromal cells after adipogenic diff erentiation in vitro. PP204 D.-C. Wagner In vivo infarct volumetric analysis upon experimental stroke in rat using a 1.5T clinic MR scanner – an investigation of lesion development comparing local versus systemic stem cell administration PP205 B. H. Walpoth Feasibility assessment of a new device for intraoperative laser and cell therapy in the pig heart PP206 E. Wandel Interaction of leucocyte antigen cd97 and the activation associated endothelial receptor thy-1 (cd90) Late Submissions PP223 S. Arain Online monitoring of DO and pH in multiwell plates - A novel approach to defi ned conditions for cell cultivation PP224 T. Douglas Hydrostatic pressure (HP) stimulation of human mesenchymal stem cells (hMSCs) seeded on collagen-coated titanium substrates and polycaprolactone (PCL) scaff olds PP225 J. F. Douglas Renal Replacement Therapy (RRT) cannot solve the problems of Chronic Kidney Disease (CKD). Research into CKD prevention, nephron preservation and renal tissue regeneration urgently requires funding PP207 C.-H. Wang Preparation of injectable collagen matrix for adipose tissue engineering PP226 A. Efi menko Angiogenic properties of adipose-bone marrow derived mesenchymal stromal cells under hypoxia and infl ammation in vitro PP208 K. Warstat Attachment of MSC to ECM proteins does not infl uence their TGF-ß1 responses. PP227 N. W. Guldner Detoxifi cation, titanization and endothelialization of glutaraldehyde- fi xed collagen scaff olds PP209 A. Wegehaupt Library screens for the identifi cation of therapeutic targets PP228 N. Nonoguchi Efficient induction of neuronal progenitors from bone marrow stromal cells PP210 F. Wegner Analyses of primary human fetal cells and derived mesencephalic neural precursors in vitro PP229 K. Ullmann Identifi cation, validation and characterization of novel prostate cancer specifi c microRNAs PP211 PP230 R. Slavkovsky Hyaluronan is an active molecule in the angiogenesis. In vitro study of the eff ect of hyaluronan on human dermal microvascular endothelial cells (HDMVEC) U. Wehrmeister Comprehensive in vitro model for the engineering of microvasculature - evaluation of morphological and functional data PP212 T. Weigel Shape-memory polymer nanocomposites responsive to alternating magnetic fi elds 48 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 49 Evening functions Special Dinner Lecture Wednesday, 17 October 2007, 7:30 pm Old Stock Exchange The Old Stock Exchange situated close to the Market Square behind the Old City Hall was built in 1687 and is the only baroque building in Leipzig. Here merchants once concluded contracts when fairs were underway. The spending hall on the first floor is now used for small functions. We are pleased to invite you here for the Special Dinner Lecture. Oliver Brüstle from the Institute of Reconstructive Neurobiology at the University of Bonn will speak about “Human ES Cell-Derived Neural Stem Cells.” Get together Thursday, 18 October 2007, 5:30 pm Following the scientific program, we would like to invite you to a pleasant and informal evening in the exhibition area at the Congress Center. The Get-together is included in the registration fee for all participants, exhibitors and sponsors. Social Evening Friday, 19 October 2007, 8:00 pm Modern Research Meets Colourful History Leipzig certainly does have a colourful history. During the evening function you will have the opportunity to find out more about on of the city´s historical highlights – the Moritzbastei. The Moritzbastei is the only remaining part of the ancient city fortifications. In the 70’s students began to work on the Moritzbastei, freeing it of the debris it was filled with and turning it into a students’ club. The evening will include some tasty delicacies reflecting regional cuisine as well as entertainment. Price per person: 60.00 € includig 19% VAT (including food and beverages) 50 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 51 Sponsors & Exhibitors GOLD SPONSOR Pluristem Therapeutics Inc. Haifa SILV ER SPONSOR EXHIBIT ORS 38 Labotect Labor-Technik Göttingen GmbH Göttingen 15 Lehmanns Specialised Bookstore Leipzig 44 Leica Mikrosysteme Vertrieb GmbH Wetzlar 10 Matricel GmbH Herzogenrath 24 Metabion International AG Martinsried 39 Boo th Millipore GmbH Schwalbach 54 Boo th Thermo Electron LED GmbH Langenselbold 42 NeuroProgen GmbH Leipzig Leipzig — EXHIBIT ORS 52 Boo th Boo th AbD Serotec Oxford 45 Miltenyi Biotec GmbH Bergisch-Gladbach 51 Advalytix AG Munich 35 Multi Channel Systems MCS GmbH Reutlingen 53 Amaxa GmbH Cologne 12 Nikon GmbH Düsseldorf 14 Zürich 46 Applied Biosystems Applera Deutschland GmbH Darmstadt 34 Nisco Engineering AG Beckman Coulter GmbH Krefeld 47 Olympus Deutschland GmbH - Mikroskopie Hamburg 36 Becton Dickinson GmbH Heidelberg 52 ORF Genetics Reykjavik 30 BioE Inc. St. Paul, MN 4 PAA Laboratories GmbH Cölbe 5 Bionas GmbH Rostock 49 PeproTech EC Ltd. London 29 Regensburg 28 BIOSAFE SA Eysins 9 PreSens Precision Sensing GmbH biosaxony Dresden 32 Progenitor Cell Therapy LLC Hackensack, NJ 6 Bioscora GmbH Leipzig 19 Projektträger Jülich - Forschungszentrum Jülich GmbH Berlin 20 BioSpherix, Ltd. Redfield, NY 31a QIAGEN GmbH Hilden 18 Carl Zeiss MicroImaging GmbH Jena 50 R&D Systems Europe Ltd. Abingdon 7 Vancouver, BC 27 Charles River Laboratories GmbH Sulzfeld 23 StemCell Technologies, Inc. Chip-Man Technologies Ltd. Tampere 31 Translational Centre for Regenerative Medicine Leipzig 41 Cluster Life Sciences Mitteldeutschland Halle/Saale 40 TÜV Süd Product Service GmbH Munich 3 Cytonet GmbH & Co. KG Weinheim 17 VITA 34 AG Leipzig 22 DASGIP AG Jülich 33 Wilhelm-Ostwald-Gymnasium Leipzig 11 Oberkrämer 25 Frankfurt 26 Eppendorf Biochip Systems GmbH Hamburg 16 Zellwerk GmbH Eufets AG Idar-Oberstein 21 Zinsser Analytic GmbH Ewald Innovationstechnik GmbH Bad Nenndorf 48 Fraunhofer Life Sciences Alliance (VLS) Hanover 13 SPONSORS Future Medicine Ltd. London 8 Aastrom Biosciences, Inc. Ann Arbor, MI Cambridge Asbach German Society for Regenerative Medicine e.V. Frankfurt 2 Antitope Ltd. Gesim mbH Radeberg 1 Dunn Labortechnik GmbH HiSS Diagnostics GmbH Freiburg 43 Eccocell Biotechnologie GmbH Graz Munich Dresden Invitrogen Corporation Carlsbad, CA 28a Maiwald Patentanwalts GmbH Labor Dr. Reising-Ackermann und Partner Leipzig 37 Saxony State Ministry for Economic Aff airs and Labor 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 53 Catering Outside Exhibition plan Level +1 Lecture Hall 3 Lecture Hall 5 Exibition Booths no. 33–54 Terrace Catering Smoking Area Exibition Booths no. 1–32 Elevator Exhibition plan Level 0 Elevator Catering Lecture Hall 4 Catering Atrium Internet Foyer West Elevator Atrium Lecture Hall 1 Preview Area Elevator 54 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 55 General information Congress Coordinator Professor Frank Emmrich Fraunhofer Institute for Cell Therapy and Immunology Deutscher Platz 5e 04105 Leipzig Public Transport You are authorized to use public transport (within Leipzig and including airport) with your name tag for the duration of the meeting, 17–20 October 2007. Registration Fee Congress Dates Wednesday October 17, 2007 04:00 pm–07:00 pm Thursday October 18, 2007 07:30 am–08:00 pm Friday October 19, 2007 07:30 am–08:00 pm Saturday October 20, 2007 08:00 am–03:00 pm Congress Venue Congress Center Leipzig Messe-Allee 1 D-04105 Leipzig www.ccl-leipzig.de Language The official language of the congress is English. Participation/ Badges Official congress name tags will be required for admission to all congress functions, scientific sessions and exhibition areas. Individuals who lose their name tags will have to pay a fee of 15 € to obtain a replacement tag. Exhibition Information The exhibition of the 3rd World Congress on Regenerative Medicine, featuring commercial displays of pharmaceutical and product companies, medical publishers will be located in the foyer areas of the Congress Center, floor 0 and +1. The exhibition will be open on the 18 th of October, 9:00 am–8:00 pm and on the 19 th of October, 9:00 am–6:00 pm. The Get-together on 18 th of October will take place in the exhibition area. Registration fees On-Site Day Ticket 18 th 19th 20th — — — Fraunhofer Life Science Symposium 175.00 € Speaker (1) 275.00 € 175.00 € Member (2) 400.00 € 250.00 € Non-member 425.00 € 285.00 € Student/Resident (3) 150.00 € 80.00 € Accompanying person (4) 160.00 € 80.00 € (1) This registration fee is valid only for delegates who will give an oral presentation as well as for staff members of the University of Leipzig. (2) This registration fee is valid for members of the following organisations: ASAIO, DGBMT, DGfI, ESAO, ESB, ESOT, ETCS, GBZ, GRM, ICRS, ISAC, REGENERATE, TERMIS. (3) Please provide proof of your status with the registration. (4) Please note that accompanying persons are not permitted to participate in the scientific program. The registration fee includes: > Participation in the scientific program > Name tag and delegate bags incl. abstracts > Use of public transportation in Leipzig > Food and beverages during the conference Poster Presentation The poster exhibition will be situated in the Conference Center, Floor +1. Presentations of posters will be on Thursday, October 18, 2007 during the Get-together (5:30– 7:30 pm) and on Saturday, October 20, 2007 during the coffee break (10:00–11:00 am). The Poster award ceremony will be on Saturday as well at 12:30 pm. > Get-together Materials for putting up the posters will be provided. 56 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 57 WWWHEILLEIPZIGDE )HRÒ/FF2OADÒ0ROFI ZÒ"Ò4OUAREGÒ6Ò4$)ÒÒCMÒ03Ò+RAFTSTOFFVERBRAUCHÒKOMBINIERTÒLÒKMÒ#/%MISSIONÒKOMBINIERTÒÒGKM Ò3TRENGÒ,IMITIERTESÒ3ONDERMODELLÒMITÒ3ERIENNUMMER Ò3ONDERKENNZEICHNUNGÒ(%),ANDER How to get to the Congress Center Leipzig from the airport The Airport Express runs every 30 minutes between the airport and Leipzig main station, stopping at “Leipzig-Neue Messe” station on the way. The ride to the Exhibition station takes 8 minutes. 2 by train You can get to Leipzig Exhibition Centre from the city centre taking tram no. 16. From Leipzig main station to “Messegelände” (terminus) – the ride takes approx. 15 minutes. Trams run every 10 minutes and take you almost right up to the main entrance of the congress center. 3 1 by car Please follow the signposts in and around Leipzig. Leipzig Exhibition Centre (“Messegelände”) is very well signposted. The parking guidance system is helpful for finding parking spaces and will guide you quickly and safely to any free parking space. 5 1 8 1 1 7 %INEÒ4RADITIONÒAUSÒ,EIPZIG R $E ÒÒ ÒALLEÒ-ODELLEÒINÒDERÒ&ARBEÒ¨"LACK-AGIC©ÒODERÒ¨'ALAPAGOS!NTHRAZIT© U ÒÒÒÒÒÒÒÒÒÒÒÒÒÒÒÒÒÒ5NSTERBLICHKEITÒINÒ!CTIONÒUNDÒ4EMPO ÒLIMITIETÒA Ò NG FÒ T RE RÒ( Ò-O %), AN D EL LE E Ò- O D L LEÒÒS -OTORISIERUNGÒZ"Ò Ò4$)ÒÒ03ÒÒ4$)ÒÒ03ÒÒKMÒJiHRLÒ&AHRLEISTUNGÒ6ERTRAGSDAUERÒÒ-ONATEÒÒ,EASING3ONDERZAHLUNG AU DE ST R IMITIERTÒ !BÒSOFORTÒBEIÒUNSÒERHiLTLICHÒDIEÒ4OUAREG3ONDEREDITION GÒL FÒ 58 EN 3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E 6 Seaside Park Hotel**** 2 Hotel im Sachsenpark*** 3 Vivaldi Hotel*** 4 ibis Leipzig Zentrum** 5 Renaissance Hotel**** 6 Moritzbastei 7 Old Stock Exchange 8 Main station OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY 59