胡瓊文教授 (Chiung-Wen, Hu)

胡瓊文教授 (Chiung-Wen, Hu)
Chiung-Wen Hu received her diploma in Chemical Engineering from
National Taipei Institute of Technology, Taiwan in 1996. She received her
Ph.D degree in Chemical Engineering from the University of Birmingham,
UK in 2001. Her thesis work focused on anaerobic organism metabolism,
process kinetics, and analytical chemistry. After moving back to Taiwan,
she had a post-doctoral research training at the Division of Environmental
Health & Occupational Medicine of National Health Research Institutes,
for two years (2002-2004). She then joined the faculty of Chung Shan
Medical University (CSMU) in Taichung, Taiwan. She is now a professor
in the Department of Public Health at CSMU.
In the past decade, her research work has been focused on the LC-MS/MS method development for
quantitative analysis of various DNA adducts. The formation of DNA adducts by carcinogens has
been recognized to be an essential stage in the process by which such compounds cause cancer. It
was believed that the detection of DNA adduct would be useful in the assessment of carcinogenic
hazard and possibly of risk. However, its detection has been a challenge since it usually exists at
extremely low levels in vivo, and biological samples (i.e. urine, blood) always contains many
interferences that would highly reduce its measurement accuracy. There have been more than 10
LC-MS/MS methods established by her research team that can overcome the sensitivity and
selectivity issues in analysis of DNA adducts. With the use of isotope internal standards and on-line
solid-phase extraction (SPE), the developed methods could allow for a direct and high-throughput
analysis of the targeted analytes without compromising quality and validation criteria. Recently,
such analytical concept and technique have been extended to the quantification of the metabolites of
environmental pollutants (e.g., tobacco, areca nut and nitrosamines).
Chiung-Wen Hu has been invited to join the “European Standards Committee of Urinary (DNA)
Lesion Analysis” as a member since 2007 and participated in analytical methods comparison among
international laboratories. She received Ta-You Wu Memorial Award from National Science
Council, Taiwan in 2009. She also received Top Ten Female Outstanding Young Person Award in
Taiwan in 2011.