The LAGEP (Laboratory of Automatic Control and Chemical Engineering) develops PHARMACEUTICAL ENGINEERING

| L
ABORATORY
CHEMICAL ENGINEERING AND AUTOMATIC CONTROL (LAGEP)
UMR 5007, UNIVERSITÉ CLAUDE BERNARD LYON 1 – CNRS – CPE LYON
HATEM
FESSI
Professor, Université Claude Bernard Lyon 1
The LAGEP (Laboratory of Automatic
Control and Chemical Engineering) develops
its research activities at the interface of
Engineering and Health Sciences leading as
well to base research as well as to transfer
towards the important industrial sector in the
region Rhône-Alpes. Its objective is to gather
the experts in Automatic Control, Chemical
Engineering and Pharmaceutical Engineering
from both the University and the CNRS (Centre
National de la Recherche Scientifique) for the
development of research activities in their
domain of expertise as well as cross-domain
activities organized in the four research themes
presented below.
THEMATIC GROUPS
NONLINEAR SYSTEMS AND PROCESSES
The research topic of the SNLEP team concerns
the theorical development and implementation
of tools in order to: Analyze, Modelize, Simulate,
Control and Optimize Systems in Process
Engineering.
Our theoretical developments are motivated
by practical applications encountered through
collaborations with industrial and academic
partners. More specifically, our work focuses
on model design and reduction, parametric
identification, observation, diagnosis and
control.
PHARMACEUTICAL ENGINEERING
The design of new formulations containing
active molecules is the key point to enhance the
efficiency. These formulations can be fabricated
in the form of capsules or tablets using various
engineering processes in order to control the
active molecules location and distribution inside
the used matrix. The active molecules or the
final drug should answer various criteria driven
by the targeted diseases, application way and
patient’s age.
• Pharmaceutical science (formulation and
• Solid elaboration (lyophilisation and
crystallisation)
• Capsules preparation, colloidal physics and
physical chemistry
• Modelling and process engineering,
• Life science (biodisponibility, skin penetration)
SOLID ENGINEERING
The ‘Solid Engineering’ group is focused on the
study of the solid manufacturing processes from
the initial state (obtained by dissolution, wet
granulation, raw material division) to the final
dry state. Solid particles are mainly obtained by
such processes as crystallization-precipitation,
agglomeration, conductive, convective or spray
drying, freeze-drying. The scope of the group
activities goes from the study of the internal
fundamental mechanisms (heat and mass
transfer, solid phase transition, polymorphism,
desolvatation) to the process monitoring and
control in an industrial context.
PROCESS DYNAMICS AND CONTROL OF
SYSTEMS OF CONSERVATION LAWS
The design of energy efficient, reliable and
intensive processes requires the development
of dynamical models of complex, network
structured processes. Different multi-scale
processes are considered such as adsorption,
reactive extrusion processes, heat pumps,
thermal storages using phase changes
in fluids and cristallization in emulsion
processes, involving mass and heat transport
in heterogeneous and reactive media with
moving interface. Nonlinear control laws are
developped based on their formulation as
port Hamiltonian systems or input-output
contact systems. Control laws for systems of
conservation laws are developed based on the
semi-group theory, Riemann invariants with
recent developments for systems with moving
interfaces.
| Figures
Centre, top: experimentation using Buchi atomizer
Centre, bottom: Hair decontamination studies
Right, top: Density Measurement of caffeine
tablets by X-rays
Right, bottom: nanoparticles PLA.
| EQUIPMENT
› Climatic chamber,
› In situ probe (video, FBRM, NIR)
› Contact vacuum dryer,
› Crystallization setups from 100ml to 30 litres
› DSC, TGA, labtop SEM, flow ability ring shear
tester ,
› 3D-powder mixer , HPLC, GPC, vaccum
studies,
› Nanosizer, ultracentrifugation,
› Freeze Dryer
› DVS (dynamic vapour sorption analyzer)
› Rheometer
| EXPERTISES
› Crystallization-precipitation-agglomeration
› Drying (contact, convective), spray-drying
› Freeze-Drying, wet granluation
› Pharmaceutical process,
COLLABORATIONS
The LAGEP has numerous collaborations within
national and international projects. The funding of
these project is obtained through public agencies
(ANR, FUI, GGCIS, European Union) or industrial
partnerships in chemical engineering (IFP,
TOTAL, RHODIA, ARKEMA ..), systems and control
engineering (Renault V.I., IFP, ACSISYSTEMES…)
and pharmaceutical engineering 5SANOFI
AVENTIS, VOVARTIS, PFIZER, L’OREAL, J&J, ..).
KEYWORDS
Encapsulation, targetting, Emulsions,
Nanoparticles,pharmaceutical technologies,
Diagnostic, therapy, automatic control,
simulation, identification, separation processes,
chemical reactors, Crystallization, precipitation,
Drying, freeze-drying,
STAFF
Vincent Andrieu Junior researcher of the CNRS
Christine Bebon Associate professor
Marie-Alexandrine Bolzinger Associate professor
Sandrine Bourgeois Associate professor
Stéphanie Briancon Professor
Nadia Chapel Administrative and Financial Officer
Catherine Charcosset senior researcher of the CNRS
Yves Chevalier senior researcher of the CNRS
CHOROT Thierry Associate professor
Claudia Cogne Associate professor
Didier Colson Associate professor
Genevièvre Conod-Nardi Technician
Françoise Couenne Junior researcher of the CNRS
Séverine Crastes-Vessot Professor
Ghania Degobert Associate professor
Hélène Desmorieux Associate professor
Valerie Dos Santos Martins Associate professor
Pascal Dufour Associate professor
Hamid Elaissari senior researcher of the CNRS
Hatem Fessi Professor
Koffi Fiaty Associate professor
Emilie Gagniere Associate professor
Olivier Garrigues Engineer
Hassan Hammouri Professor
Boussad Hamroun Associate professor
Christian Jallut Professor
Jean-Paul Klein Professor
Pierre Laurent Associate professor
Denis Mangin Associate professor
Jean-Claude Marques Associate professor
Bernhard Maschke Professor
Madiha Nadri Associate professor
Sami Othman Associate professor
Roman Peczalski Professor
Jocelyne Pelletier Engineer
François Puel Associate professor
Mickael Rodrigues Associate professor
Ulysse Serres Associate professor
Nida Sheibat-Othman Junior researcher of the CNRS
Sebastien Urbaniak Technician
Claire Valentin Professor
Jean-Pierre Valour Engineer and Project Officer
Xu Cheng-Zhong Professor
3-6 Post-Docs
40-45 PhD Students
10-15 Graduate Students
| Figures
Left, top: skin description
Left, bottom : Pilot Freeze-dryer
Right, top : Polymers particles preparation
Right, bottom : monodisperse particles
DOMAINE SCIENTIFIQUE LYONTECH – LA DOUA
LAGEP – UNIVERSITÉ CLAUDE BERNARD
LYON 1
Bâtiment CPE Lyon
43 Boulevard du 11 Novembre 1918
69 622 Villeurbanne cedex
France
TEL.: 33 (0)4 72 43 18 93
FAX: 33 (0)4 72 43 16 82
[email protected]
www.lagep.univ-lyon1.fr