sun & environment: get connected, get protected

SUN & ENVIRONMENT:
GET CONNECTED, GET PROTECTED
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EDITORIAL
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The mission of the L’Oréal Group is to offer the best of beauty to all
women and men on the planet and Innovation has been a driving
force for L’Oréal growth. The diversity of hair and skin types and the
diversity of beauty needs are a vital part of the creative processes at
L’Oréal Research & Innovation.
Our commitment to better understanding skin and hair diversity can be
fully appreciated in technological advances in hair care and coloration
and in photoprotection.
Furthermore, L’Oréal Research endeavors to identify mechanisms of
skin sensitivity to the light, in particular to UVA light, in different parts
of the world. Thanks to “in vitro“ skin models, we have deciphered the
biological influences of UV light and of different environmental factors
on this particular tissue.
Today, given the diversity of skin types and the variations of environmental conditions, a personalized monitoring of environmental risks is
indispensable. In relevant prevention strategies, new technologies, like
flexible sensors, are paving the way for individualized connected environmental protection.
Michèle VERSCHOORE, MD
Medical Director,
L’Oréal Research and Innovation,
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G E T
C O N N E C T E D ,
G E T
P R O T E C T E D
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SUN & ENVIRONMENT:
GET CONNECTED,
GET PROTECTED
5.00 PM VANCOUVER CONVENTION CENTER:
ROOM: WEST 118 - 120
TUESDAY, JUNE 9TH - 5PM - 7PM
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Opening Remarks
Françoise BERNERD
5.05 PM
Evolutionary Adaptation of the Skin
to the Environment
Mark SHRIVER
5.30 PM
Effect of Sunlight and Pollution on the Skin
Henry W. LIM
6.00 PM
An Integrated Strategy Against Environmental Stress
Didier CANDAU
6.30 PM
Stretchable Bioelectronics for Continuous
Characterization and Monitoring of Skin Health
Roozbeh GHAFFARI
6.55 PM
Closing Remarks
Mark SHRIVER
E N V I R O N M E N T :
M
L’Oréal Research & Innovation Fellow,
Head of Light and Pigmentation
Research Group. Advanced Research,
France
Associate Professor of Anthropology
and Genetics at Penn State University,
State College, USA
&
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Co-Chairman
Françoise BERNERD, PhD
Chairman
Mark SHRIVER, PhD
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G E T
C O N N E C T E D ,
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P R O T E C T E D
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Mark SHRIVER, PhD
Associate Professor of Anthropology
and Genetics at Penn State University,
State College, USA
EVOLUTIONARY ADAPTATION OF THE SKIN TO THE ENVIRONMENT
There are many sources of information regarding the physiology and pathophysiology of the human skin and its responses to
environmental exposures. Human evolution has provided a series of natural experiments as humans first spread across the natal
continent Africa and then across the rest of the world. Although human populations can differ substantially in superficial traits
such as skin pigmentation, skin response to UVR, hair texture, and facial features, the levels of genetic diversity genome-wide are
very low. “Race” as a means to organize and conceptualize human genetic and phenotypic variation is thus only of limited utility.
A more useful model within which to investigate human diversity, the population-genomic model explicitly recognizes that the
genome is a composite of many local regions with diverse evolutionary histories. Dermatological differences among populations
can provide the means to investigate the physiology of skin biology. Admixture mapping methods, some of the most statistically
powerful approaches to gene discovery, are ideally suited to identifying the genetic factors underlying phenotypic differences
among populations. Given many of the skin differences across the world’s populations are the result of local adaptation to the
environment, locating and investigating these genes can and should give us many insights into the interaction of skin and the sun.
Examples of will be given using the discoveries of the genes that have lightened the skin of Europeans and physical differences
in skin pigmentation and skin responses across several populations.
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G E T
C O N N E C T E D ,
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P R O T E C T E D
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Henry W. LIM, MD
C.S. Livingood Chair and Chairman
Department of Dermatology
Henry Ford Hospital
Detroit, Michigan, USA
EFFECT OF SUNLIGHT AND POLLUTION ON THE SKIN
Sunlight as it reaches the surface of the earth consists of ultraviolet (UV)-B, UVA, visible light and infrared. The major biologic effects of acute exposure to UVB radiation are cutaneous erythema and vitamin D synthesis, while UVA,
tanning. Chronic effect of UVB is photocarcinogenesis, and UVA, photocarcinogenesis and photoaging. Recent studies have also pointed out that longwaves UVA1 are more harmful than previously thought with huge impact in DNA lesions formation, photoimmunosuppression and alterations of many biological functions. Other radiations can also be deleterious and have to be taken into account such as Visible light which is needed for general illumination but now shown
to be responsible for induced pigmentation lasting up to 3 months, and more pronounced in dark skinned individuals.
Infrared A radiation has been shown to contribute to photoaging. Emerging data also show that air pollution has detrimental
effects on human skin. Therefore, development of better and global protective measures against all these environmental
injuries, UV rays and beyond, have to be considered for the future.
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G E T
C O N N E C T E D ,
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P R O T E C T E D
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Didier CANDAU, PhD
Senior Research Associate, Applied Research
Anti-ageing and Photoprotection Department
L’Oréal Research and Innovation, Chevilly-Larue, France
AN INTEGRATED STRATEGY AGAINST ENVIRONMENTAL STRESS
Diversity of populations and skin colors, as well as variety of external stress require a broad and integrated strategy of protection in each product and each use. To face this challenge, we will see, from the usual ones to the more innovative ones,
technologies that allow us to broaden the scope of protection and to give an appropriate response.
1. A broad and overall protection based on our current tool box for short-term developments.
2. Identification of innovative systems using all technical tools from filters to biological protective molecules.
Altogether these approaches will aim at offering a broader photoprotection by i) a physical surface photoprotection able to
cover long UVA between 370 and 400 nm and ii) a biological photoprotection with appropriate anti-oxidants (AOX). AOX
being no longer considered as formulation aids, but really as auxiliary of photoprotection, associated with the filters system
and formulated so that their complementarity is expressed.
3. Evaluation of photoprotection efficacy provided by the overall system using biological and clinical end points
including pigmentation.
4. T
he final dimension from efficacy to efficiency with a finished product combining photoprotection performance and an
adequate texture for optimal conditions of use.
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G E T
C O N N E C T E D ,
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P R O T E C T E D
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Roozbeh GHAFFARI, PhD
MC10 Technology Inc Co-Founder & Vice President,
MIT Research Laboratory of Electronics,
Los Angeles, USA
STRETCHABLE BIOELECTRONICS FOR CONTINUOUS
CHARACTERIZATION AND MONITORING OF SKIN HEALTH
Human skin is a living organ with soft, stretchable and dynamically changing characteristics; whereas wearable devices are
largely planar, rigid and non-deformable. Here, we present novel materials, mechanics and designs for ultrathin skin-coupled
sensors and microelectronics systems, called ‘epidermal electronics’, which can mechanically match the physical properties
and curvilinear geometries of skin. We demonstrate microfabricated arrays of sensors configured in ultrathin, flexible formats
for continuous monitoring of skin temperature, thermal and electrical conductivity, skin modulus, pH, and movement. Quantitative analyses of strain over various anatomical locations and electronics performance under stress illustrate the utility of
these systems to laminate on skin, for clinical diagnostics and continuous health monitoring applications. Sleep study analysis,
continuous monitoring of sweat, physiology, and dermatologic analysis of skin mechanical properties are all enabled using this
platform, thus highlighting promising new directions in skin health enabled with epidermal electronics. S U N
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G E T
C O N N E C T E D ,
G E T
P R O T E C T E D
www.congress.loreal.com/2015-wcd.php
www.loreal.fr/
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