Professor Steven A Siegelbaum

You are invited to attend a seminar by
Professor Steven A Siegelbaum
Regulating memory storage by trafficking HCN1 channels to neuronal dendrites
Ion channels are often selectively targeted to distinct neural compartments where they regulate specific aspects of neural
activity. The HCN1 hyperpolarization-activated cation channels are highly enriched in the distal dendrites of CA1 pyramidal
neurons in the mammalian hippocampus, a brain structure critical for memory storage.
In this seminar, Professor Siegelbaum (Chair of Neuroscience and Professor of Pharmacology at Columbia University
Medical Center, New York City, USA) will describe how HCN1 channels act to constrain both the excitatory effects of
cortical inputs that innervate CA1 distal dendrites and hippocampal-dependent learning and memory. He will discuss
how the HCN1 channel auxiliary subunit, TRIP8b, and the extracellular signaling molecule Reelin are necessary for the
dendritic localization of these channels, and how alterations in Reelin signaling may contribute to HCN1 mislocalization
in neuropsychiatric disease.
Event Details
Date:
Time:
Venue:
Monday 20 April 2015
4 pm
Confucius Institute,
Building 202, Level 4, Room 2
RMIT Bundoora campus west
Clements Drive (off Plenty Road)
Bundoora, Victoria
RSVP
Contact: Michelle Nicolo
Email: [email protected]
Tel. +61 3 9925 6606
www.rmit.edu.au/research/institutes/healthinnovations
www.rmit.edu.au
14087 0415
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