In Vivo - Sinerga

EYEDREN
The eye-contour
refresher
EYE-CONTOUR
Lifestyle and environment act on the appearance of
evident and premature age signs, especially in a fragile
and thin area such as eye contour.
Fundamental actions to be undertaken:
-
Hydrating and restructuring, to maintain a suitable
moisture and counteract sagginess
-
Soothing, to correct and prevent damages to
cutaneous structures
-
Draining to promote the improvement of eye bags
and dark circles
EYEDREN
Active ingredient containing Ethyl Ximeninate and vegetal aminoacids
enclosed in lipophilic vesicles that enhance cutaneous bioavailability:
EYEDREN PROVEN EFFICACY
• Lightens the under eye shadows
• Brightens the eye area and eases dark circles
• Aging signs minimizing
EYEDREN
INCI Name
Ethyl Ximenynate, Potassium Lauroyl Wheat Amino
Acids, Palm Glycerides, Capryloyl Glicine
Ethyl Ximenynate is obtained by esterification of
Ximenynic Acid from Ximenia (Olacaceae families).
ETHYL XIMENINATE
Ethyl Ximenynate has a renown effect on the metabolism of
arachidonic acid by:
•
Preventing the release of arachidonic acid from membrane
phospholipids by acting on phospholipases
•
Preventing the cause of edema and swelling: the generation of
edematogenic leukotrienes by lipoxygenases (LO)
•
Preventing cycloxygenases (COX) and the generation of PGE2,that
increases capillary leaking and slows down microcirculation
1
Nugteren DH, Christ-Hazelhof E, Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesis,
Prostaglandins. 1987 Mar;33(3):403-17.
2Croft KD, Beilin LJ, Ford GL, Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty
acids, Biochim Biophys Acta. 1987 Oct 17;921(3):621-4.
EYEDREN efficacy
In Vivo TEST
•
Eyes Dark Circles: Spectrophotometry
•
Skin roughness: 3D Photo imaging
analysis
•
Self Assessment
EFFICACY PROTOCOL
22 healthy female, subjects, 44-64 years old, low/moderate roughness grade
on the periocular area
Cream 3% Eyedren Vs Placebo
Eye contour, double blind
Twice a day, 4 weeks
T0, T2 weeks, T4 weeks
Eyes circles, skin profilometry
Derming Clinical Research and Bioengineering Institute, Monza Italy
In Vivo
SPECTROPHOTOMETER
T0 (BEFORE TREATMENT)
DETECTOR
(UV total Spectrum Area)
LIGHT SOURCE
In Vivo
T4 (AFTER TREATMENT)
DETECTOR
(UV total Spectrum Area)
LIGHT SOURCE
DARK CIRCLES REDUCTION
In Vivo
+ 7,7% brightness
Total spectrum area
7200
7000
6800
Placebo
6600
Eyedren 3%
6400
6200
6000
T0
T4
After 4 weeks, Eyedren 3% cream induced a clinically relevant increase ( + 7,7%) of the total
spectrum area corresponding to a reduction of the eyes circles colour.
PRIMOS®
•
•
•
Optical in vivo measurements
Fast and efficient solution
Objective and reliable method
3D-Measuring technology
by means of stripe projection
In Vivo
3D PHOTOS BY PRIMOS®
T0 (BEFORE TREATMENT)
In Vivo
T4 (AFTER TREATMENT)
Photo imaging analysis has evidenced a clinical reduction of all profilometric parameters.
Wrinkles appear less evident and deep.
In Vivo
CLINICAL ASSESSMENT
T0 (baseline)
2 weeks
4 weeks
3% Eyedren performed a
significative improvement in
all profilometric (wrikles) and
spectrofotometric
parameters (dark circles).
EFFICACY ASSESSMENT
In Vivo
Investigator’s Judgement
100
14
48
80
62
MEDIUM
%
60
MARKED/VERY MARKED
38
40
20
24
14
0
Placebo
Eyedren 3%
ABSENT/POOR
EFFICACY ASSESSMENT
In Vivo
Volunteers’ judgement
100
80
%
60
33,3
33,3
23,8
14,3
19,1
MARKED/VERY
MARKED
47,6
57,1
57,1
40
20
MEDIUM
ABSENT/POOR
33,4
28,6
28,6
23,8
0
Eye circles
Eye puffiness
Deep wrinkles
Fine lines
TECHNICAL DATA
INCI Name
Ethyl Ximenynate, Potassium Lauroyl
Wheat Amino Acids, Palm Glycerides,
Capryloyl Glicine
Aspect:
Fluid gel
Colour:
From yellow to amber
Recommended use
2-5%
TOXICOLOGICAL PROFILE
in vitro skin irritation
NOT IRRITANT
in vivo skin irritation
NOT IRRITANT
in vitro eye irritation
NOT IRRITANT
EYEDREN CLAIMS
Eye revitalizer
Dark circles
minimizer
Complexion
brightener
Lines smoother
Rested-looking
eyes
Look refresher
17
EYEDREN
The eye-contour
refresher