Naturally balance their intestinal flora!

Naturally balance
their intestinal flora!
NOW INCLUDES
PREBIOTICS
Balanced and proven intestinal support
ICS
PRE
B I OT
®
Diarsanyl has been tried and trusted by veterinary surgeons for 8 years.
The new Diarsanyl Plus contains the same unique combination of
ingredients as the original product:
®
Montmorillonite
• Maintains intestinal function by:
~ coating and protecting the enterocytes
~ absorbing toxins
Na , Mg and K ions
+
2+
+
• Help maintain electrolyte levels
Dextrose
• Provides a much needed energy source for the small intestinal enterocytes
Montmorillonite
Coating ability1
100
Mucous
90
Coating ability
(m2 per g)
80
x4
70
60
50
40
30
20
10
0
Kaolin
Enterocytes
Absorbing properties
(m2 per g)
700
Montmorillonite
Absorbing properties1
600
x15
500
400
300
200
100
0
Kaolin
Montmorillonite
Plus
NOW
CONT
PREB AINS
IOTIC
S
Prebiotics
Diarsanyl Plus now contains fructooligosaccharides (FOS), prebiotics
which are scientifically proven to:
®
•Maintain normal intestinal flora
by promoting the growth of “good
bacteria” such as bifidobacteria
and lactobacilli, at the expense
of potentially harmful pathogenic
bacteria
• Stimulate the production of the
short chain fatty acids (SCFA's)
acetate, propionate and butyrate,
which are important energy sources
for the large intestine
7,8
2,3,4,5,6
Control
10
6 hours
FOS
9.8
5
SCFA Production
9.6
Log CFU/ml
24 hours
12 hours
6
9.4
9.2
4
3
2
9.0
1
8.8
8.6
Bifidobacteria
Lactobacilli
Clostridium
perfringens
Effect of FOS on intestinal flora in dogs
0
Cat
Dog
Effect of FOS on SCFA production in cats and dogs
ICS
PRE
B I OT
Now easier to administer
NEW
FORMU
L ATION
NEW S
YRING
E
I OT
®
Diarsanyl Plus 10 ml
®
Diarsanyl Plus 24 ml
PRE
PRE
ICS
Presentation
ICS
• New easy to use syringe withBtwisting mechanism of action
• New palatable formulation
• Three pack sizes, ensuring the product is convenient and
cost effective even for the largest dog
T required, according to
• Give once daily for 3-5 days, BorIOas
the following table
Dosage (graduations)
Species
Morning
Evening
Dog < 7kg
Cat
Rabbit, Ferret
Guinea Pig, Rat
1
1
Dog 7 - 18kg
1
1
Dog 18 - 30kg
I OT
2
2
1
1
Dog > 30kg
ICS
®
Diarsanyl Plus 60 ml
PRE
B
References
Ingredients
• Montmorillonite 40 g/100 ml
• Fructo-oligosaccharides 25 g/100 ml
1
2
3
4
5
• Dextrose 25 g/100 ml
• Glycerol 15 g/100 ml
• Electrolytes (sodium 1.5%,
magnesium 0.3%, potassium 0.3%)
6
7
8
Depuis (1996), Les argiles en thérapeutique digestive, Thèse Pharmacology Poitiers
Swanson K.S. et al (2002), Effects of supplemental fructooligosaccharides and mannanoligosaccharides on colonic microbial
populations, immune function and fecal odor components in the canine, American Society For Nutritional Science, Journal
of Nutrition, 132, 1717-1719
Swanson K.S. et al (2002), Effects of supplemental fructooligosaccharides plus mannanoligosaccharides on immune
function and ileal and fecal microbial populations in adult dogs, Arch Tierernahr, 56, 4, 309-318
Vickers R.J. et al (2001), Comparison of fermentation of selected fructooligosaccharides and other fibers substrates by
canine colonic microflora, American Journal of Veterinary Research, 62, 609-615
Kerley M.S. and Sunvold G.D. (1997), Favorably modifying gut flora with a novel fiber (FOS), Proceedings from a PreCongress Symposium. Gastrointestinal Health Symposium. World Congress, Annual Congress of WSAVA, FECAVA & BSAVA.
Birmingham, UK, 15-19
Swanson K.S. et al (2002), Fructooligosaccharides and Lactobacillus acidophilus modify gut microbial populations, total
tract nutrient digestibilities and fecal protein catabolite concentrations in adult dogs, Journal of Nutrition, 132, 3721 –
3731
Sunvold G.D. et al (1995), Dietary fiber in dogs: In vitro fermentation of selected fiber sources by dog and cat fecal
inoculums and in vivo digestions and metabolism of fiber-supplemented diets, Journal of Animal Science, 73, 1099 - 1109
Sunvold G.D. et al (1995), In vitro fermentation of selected fiber sources by dog and cat fecal inoculums: Influence of diet
composition on substrate organic matter disappearance and short-chain fatty acid production, Journal of Animal Science,
73, 1110 - 1122
For further information please contact:
CEVA ANIMAL HEALTH LTD
90 The Broadway, Chesham, Bucks HP5 1EG
Tel: 01494 781510 www.ceva.uk.com