Metabolic Detox Clinical Guide

Clinical Guide for Metabolic Detoxification
Science-based metabolic detoxification
formulas from the industry leader.
Reliable protocols for reliable outcomes.
The health of your patients depends on it.*
“There’s a lot of confusion out there regarding detoxification.
It’s my job to offer my patients a science-based, effective option.”*
Metabolic Detoxification:
Supporting the 3 Phases*
Metabolic detoxification consists of 3 major detoxification
Advanced Metabolic
Detoxification Formulas
pathways: Phase I (functionalization), Phase II (conjugation), and
Phase III (antiporter activity). In this process, fat-soluble toxins
must undergo transformation and become water-soluble before they
Featuring UltraClear RENEWTM
can be excreted. Water-soluble toxins entering the body do not
medical food for fibromyalgia
require transformation and are easily eliminated through the
patients formulated to
stool, sweat, or urine.
nutritionally support the 3 phases
of metabolic detoxification.
Toxic
Exposure
Toxic Exposure
UltraClear RENEW
Aids the Intestine
Intestine
Toxins enter the body. Some
are eliminated via the stool,
sweat, or urine, while others
are transported to the liver.
Elimination
Translocation
Features a low allergy
potential and balanced
solubility (osmolality),
reducing translocation
of toxins to the liver.
Phase I—Functionalization
Enzymes released by the
liver breakdown xenobiotics,
producing harmful free radicals.
Liver
Phase I Phase II
Phase II—Conjugation
Large molecules join together
with modified xenobiotics
to produce harmless, watersoluble substances, which are
released to the kidney or back
to the GI tract.
Enhances activities of
several liver detoxification
enzymes and provides
antioxidants to support
the clearance of reactive
intermediary compounds.
Translocation
Kidney
Phase III—Antiporter Activity
UltraClear RENEW
Benefits Phase I & II
Phase III
UltraClear RENEW
Benefits Phase III
Supports the excretion
of toxins with a high
alkaline reserve.
The water soluble substance is
excreted via the urine or stool.
Elimination
Clinically Tested Medical Food Program
Clinically Tested Medical Food Program
Folic Acid
80 mcg
Vitamin B12
3.6 mcg
Medical Food
Biotin
135 mcg
UltraClear RENEW™
Pantothenic Acid
UltraClear RENEW is a clinically tested medical food
Iodine
53 mcg
formulated to provide specialized nutritional support
Magnesium
160 mg
Manganese
RENEW is designed for individuals who may benefit
Chromium
patients with dental amalgams, administration of UltraClear RENEW
was associated with significant decreases in FibroQuest scores,
including pain and stiffness.
Patient benefits:
• Designed to support healthy Phase I, Phase II, and Phase III
liver detoxification function.
• Supports healthy neuromuscular function.
Flavor: Original Flavor
Serving size: About 2 Scoops (38 g)
Calories
150
Total Fat
3g
1g
0g
0 mg
Sodium
220 mg
Potassium
520 mg
Sugars
Protein
20 g
3g
9g
12 g
Vitamin A (as beta-carotene)
4000 IU
Vitamin A (as retinyl palmitate)
1000 IU
Vitamin C
300 mg
Calcium
150 mg
Iron
1 mg
1000 mg
Prune (Prunus domestica) Skin Extract
125 mg
L-Glutamine
100 mg
Watercress (Nasturtium officinale) Whole Plant Extract
67 mg
Ellagic Acid [from pomegranate (Punica granatum) Whole Fruit Extract]
50 mg
DL-Methionine
50 mg
L-Threonine
35 mg
L-Lysine
35 mg
Sulfate (magnesium sulfate)
20 mg
L-Cysteine
15 mg
Catechins (from decaffeinated green tea extract)
15 mg
35 IU
This product is Gluten Free.
42 IU
Thiamin
2 mg
Riboflavin
2 mg
Notice: This product is to be used under the direct supervision of a physician or
other licensed healthcare practitioner. Do not engage in any diet supplying less
than 800 calories per day without medical supervision.
7 mg
3.4 mg
Saturated fat content is contributed by a beneficial form of fat, medium-chain
triglycerides, which have recognized health benefits.
x
x
x
x
x
-51%
MSQ
Score
0 25 50 75100
x
x
x
x
x
-42%
FibroQuest
Total Score
0 1020 3040 5060
x
x
x
x
x
x
x
-40%
FibroQuest
Pain Subscale
Reduction in MSQ* score, a measure
of physical and mental well-being,
suggesting fewer symptoms and
better overall quality of life.
Reduction in total FibroQuest
symptoms survey score, as well as
subscales for pain and stiffness.
Lower scores generally mean greater
functional ability.
0 246810
x
Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects.
Pregnant women and women who may become pregnant should not exceed 5000 IU of
preformed vitamin A (retinyl palmitate) per day.
Vitamin E
Vitamin B6
x
Form: 28.5 oz (1 lb 12.5 oz) (798 g) Powder
Vitamin D
Niacin
0 10203040 50
Directions: Blend, shake, or briskly stir about 2 level scoops of UltraClear RENEW into 8
ounces of chilled water or juice twice daily or as directed by your healthcare practitioner.
For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4
to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting
a full daily dose.
Formulated to Exclude: Wheat, gluten, soy protein, dairy products, egg, nuts, tree nuts,
fish, crustacean shellfish, colors, artificial sweeteners, artificial flavors, and preservatives.
Clinically significant reduction (≥20)
in FIQ* score among half of subjects. ‡
-55%
FIQ Score
Ingredients: Rice protein concentrate, rice syrup solids, fructose, natural flavors,
magnesium citrate, proprietary spent hops powder (Humulus lupulus), partially
hydrolyzed guar gum, dipotassium phosphate, olive oil, medium chain triglycerides,
L-glycine, sodium chloride, calcium citrate, potassium citrate, magnesium chloride, silica,
ascorbic acid, pomegranate extract, prune skin extract, L-glutamine, zinc gluconate,
d-alpha tocopheryl acetate, watercress extract, DL-methionine, L-lysine HCl, L-threonine,
decaffeinated green tea extract, D-calcium pantothenate, L-cysteine HCl, magnesium
sulfate, vitamin A (beta-carotene, retinyl palmitate), niacinamide, copper gluconate,
pyridoxine HCl, thiamin HCl, riboflavin, chromium polynicotinate, biotin, folic acid,
potassium iodide, cyanocobalamin, and cholecalciferol.
Caution: Do not use if pregnant or nursing. Not recommended for individuals taking
anticoagulant medications.
n Baseline
n Visits 5-7
A small, preliminary clinical study at FMRC measured effects on pain, stiffness,
quality of life, and heavy metal metabolism with a clinically significant response.†
800 mg
Improved Heavy Metal
Metabolism
• Helps to address altered pain signaling. Dietary Fiber
460 mg
L-Glycine
Phase II liver detoxification. In preliminary research with fibromyalgia
Carbohydrate
1 mg
50 mcg
Proprietary Spent Hops (Humulus lupulus) Powder
nutrients in a low-allergen-potential macronutrient base to support
Trans Fat
1 mg
Chloride
from additional support for liver function, and features an array of
UltraClear RENEW has been demonstrated to be clinically effective in improving markers
of quality of life and heavy metal metabolism.
10 mg
Copper
function in patients with fibromyalgia. UltraClear
Cholesterol
230 mg
Zinc
to address altered pain signaling and neuromuscular
Saturated Fat†
36 mg
Phosphorus
Proven Clinically Effective
Reduced Symptoms & Increased Functioning
FiBROMYALGIA
Metallothionein
mRNA
Expression
x
x
x
x
x
+19%
0.3 0.2
x
0.10.00
x
x
x
+87%
Urinary Mercury
Excretion
43 2 1 0
†
x
x
x
x
Elevation of mRNA expression of
metallothionein, a cellular protein
that plays a crucial role in the
metabolism of heavy metals.
Significant elevation in creatinineadjusted excretion of mercury.
x
Study protocol consisted of a modified elimination diet plus 2 servings of UltraClear RENEW daily for 4 weeks.††
*FIQ: Fibromyalgia Impact Questionnaire; MSQ: Medical Symptom Questionnaire
‡
Represents subjects (n=4) reporting changes in total FIQ score ≥20, suggested to be clinically significant.
†Results presented as a mean of scores (visits 5-7) for all subjects versus baseline (visit 1) unless otherwise noted.
After a 4-week control phase with UltraClear MACRO® (macronutrient base) and the Standard American Diet. Seafood excluded from both diets.
††
This
preliminary subgroup analysis conducted at the Functional Medicine Research Center® (FMRC)—the clinical research arm of Metagenics, Inc.—does not demonstrate
statistically significant results.
Reference
1. Konda VR. Proprietary Laboratory Report . Gig Harbor, WA: MetaProteomics; 2009.
See the complete Metagenics product line at Metagenics.com/products
Nutraceuticals for Metabolic Detoxification
liver Support*
Nutraceuticals for Metabolic Detoxification
Directions: Take two capsules one to three times daily or
as directed by your healthcare practitioner.
Improved formula
Metagenics offers a full line of science-based formulas to help reduce
your patients’ chemical burden—to help them stay healthy and vibrant.*
Glutathione Support*
NEW FORMULA
Form: 42 Capsules, 126 Capsules
AdvaClear®
AdvaClear provides daily
support for balanced activity
of the Phase I and Phase II
detoxification pathways.*
Warning: Excess vitamin A intake may be toxic and may
increase the risk of birth defects. Pregnant women and
women who may become pregnant should not exceed
5000 IU of preformed vitamin A (retinyl palmitate) per day.
balanced detoxification.*
of key ingredients designed to
support healthy glutathione
levels and antioxidant systems
Formulated to Exclude: Wheat, gluten, soy, dairy
products, egg, nuts, tree nuts, fish, crustacean shellfish,
colors, artificial sweeteners, and preservatives.
Capsules are composed of plant-derived ingredients.
Betatene® mixed carotenoids.
†††
As Metafolin® US Patents 5,997,915; 6,254,904.
†
• Promotes overall well-being by supporting
GlutaClear provides a blend
Caution: If pregnant or nursing, or taking medication,
consult your healthcare practitioner before use.
This product is Gluten Free.
Patient benefits:
GlutaClear™
††
Heavy Metal Metabolism support*
• Features enhanced bifunctional
detoxification support with methylated
the body against oxidative stress and
detoxifying harmful compounds. Preliminary
research suggests glutathione may also help
protect mitochondria—the principle source of
influences.*
MetalloClear is designed to
• Provides antioxidant protection against
an important role in protecting
cellular energy—from damaging pro-oxidant
MetalloClear®
vitamin B12 and folate.*
in the body. Glutathione plays
help patients stay healthy by
reactive oxygen intermediates produced
providing specialized support
during the detoxification process.*
for heavy metal metabolism.*
Patient benefits:
• Helps protect cells throughout the body
from oxidative damage that may influence
cellular aging.*
Serving size: 2 Capsules†
Vitamin A [33% (834 IU) as retinyl palmitate,
67% (1666 IU) as beta-carotene††]
Vitamin C (as ascorbic acid)
• May help improve overall redox status
2500 IU
133 mg
Vitamin D (cholecalciferol)
33 IU
Vitamin E (as d-alpha tocopheryl succinate
and mixed tocopherols)
Thiamin (as thiamin mononitrate)
67 IU
Riboflavin
23 mg
17 mg
Folate (as calcium L-5methyltetrahydrofolate††† )
Vitamin B12 (as methylcobalamin)
Biotin
268 mcg
33 mcg
some heavy metals.* • Helps to modulate oxidative stress
associated with heavy metal metabolism.*
Zinc (as zinc citrate)
33 mg
6.5 mg
Selenium (as selenomethionine)
50 mcg
Copper (as copper citrate)
0.65 mg
Manganese (as manganese citrate)
1.65 mg
Molybdenum (as molybdenum aspartate)
66 mcg
Silymarin (from milk thistle seed extract,
Silybum marianum)
Catechins
50 mg
Epigallocatechin Gallate (EGCG) (from
decaffeinated green tea leaf, Camellia
sinensis)
Artichoke Leaf Extract (Cynara scolymus)
(containing cynarin and chlorogenic acid)
Watercress Whole Plant 4:1 Extract
(Nasturtium officinale)
Ellagic Acid (from pomegranate whole fruit
extract, Punica granatum)
N-Acetylcysteine
22 mg
34 mg
166 mg
134 mg
33 mg
66 mg
Sodium Sulfate
100 mg
Taurine
117 mg
Choline (as choline bitartrate)
66 mg
Other Ingredients: Hydroxypropylmethylcellulose,
magnesium stearate (vegetable), and silica.
Serving size: 2 Tablets
enzyme involved in the metabolism of
Serving size: 3 Tablets
Pantothenic Acid (as D-calcium pantothenate)
• Supports hepatic detoxification function.*
regulate the genetic expression of an
66 mcg
Zinc (as zinc citrate)
and nuclear factor-kappa B (NF-kB).*
FMRC® suggests MetalloClear may up-
5 mg
Vitamin B6 (as pyridoxine HCl)
such as tumor necrosis factor-alpha (TNF-a)
• Preliminary research conducted at the
10 mg
Niacin (as niacinamide and niacin)
through influencing signaling molecules,
Patient benefits:
Andrographis (Andrographis paniculata)
Aerial Part Extract
Turmeric (Curcuma longa) Rhizome Extract
[standardized to 95% (150 mg) curcuminoids]
Proprietary Blend of Hops (Humulus lupulus)
and Luduxin®†
5 mg
150 mg
158 mg
2645 mg
Other Ingredients: Microcrystalline cellulose, cellulose,
stearic acid (vegetable), croscarmellose sodium, silica,
and coating (water, hypromellose, medium chain
triglycerides, and hydroxypropylcellulose).
Directions: Take three tablets twice daily with food, or as
directed by your healthcare practitioner.
Vitamin C (as ascorbic acid)
500 mg
Niacin (as niacinamide)
750 mg
Selenium (as selenomethionine)
75 mcg
N-Acetylcysteine
750 mg
Broccoli (Brassica oleracea L. var. italica)
Seed Extract (providing 5 mg
sulforaphane glucosinolate)
38.5 mg
Other Ingredients: Microcrystalline cellulose,
cellulose, stearic acid (vegetable), silica, and coating
(water, hypromellose, medium chain triglycerides, and
hydroxypropylcellulose).
Directions: Take two tablets twice daily with food or as
directed by your healthcare practitioner.
Form: 120 Tablets
CAUTION: If you are pregnant or nursing, consult your
healthcare practitioner before use.
Formulated to Exclude: Wheat, soy, dairy products,
egg, milk, nuts, tree nuts, fish, crustacean shellfish, colors,
artificial sweeteners, and preservatives.
This product is Gluten Free.
Form: 180 Tablets
Warning: Do not use if pregnant, nursing, or if taking
anticoagulants.
Caution: If taking medication, please consult your
healthcare practitioner before use. Keep out of the reach
of children.
To order, contact your Metagenics Representative or call:
This product is Gluten Free and Vegetarian.
Luduxin® consists of reduced iso-alpha acids (from hops
extract, Humulus lupulus) and magnesium salt produced
via a proprietary process.
†
* These statements have not been evaluated by the
Food and Drug Administration. These products are not
intended to diagnose, treat, cure, or prevent any disease.
See the complete Metagenics product line at Metagenics.com/products
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100 Avenida La Pata
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