Directory - Colorado BioScience Association

Transcription

The Passion That Drives
Colorado’s Bioscience
Entrepreneurs Page 6
Colorado By the Numbers:
A 2010 Update on Colorado’s
Growing Bioscience Industry
Directory
of Bioscience
Companies
& Resources
Page 38
Page 12
Patient Profiles
In Courage
Page 17
Fitzsimons
LifeScienceDistrict
agreatplacetoraisean idea
Located in Aurora, Colorado, it’s one of the largest bioscience developments in the country, a place
where there’s plenty of room to grow an idea from discovery to market viability. Whether you start in the
bioscience incubator or move into a state-of-the art lab facility, everything you need is close at hand.
A cluster of talent and resources is available to you, including direct access to the more than 80 core
laboratories at the University of Colorado Anschutz Medical Campus – all just
steps away. Features throughout the district, such as parks and conference
facilities, are designed to inspire collaboration. And a nearby mix of shops,
restaurants and homes let your people thrive right along with your ideas.
For leasing and land purchase opportunities at the Colorado Science + Technology Park,
within the Fitzsimons Life Science District, call 303-324-9954.
Join the conversation at FitzScience.com
Tools, Location, Liftoff
At CSU’s Science Park
• Pre m i e r Inc ub ator Sp ac e
• L ife S c i e nc e & Tr ansl at iona l
Me d i c i ne R e s e arch
• C le an E ne rg y R e s e arch
• Sp e c i a l i z e d Fac i l it i e s
( BSL- 3 , R ad i at i on , Imag i ng )
C SU Res e arch Innovati on C enter
Innovate, Incubate, Succeed
C SU Venture s, In c .
P.O. B ox 483, For t C ol li ns, C O 80522
(970) 48 2- 2916 • w w w. csu r i c. org
Looking for a place to locate a bioscience company?
Put us under the microscope.
Metro Denver is home to some of America’s top university laboratories and research centers including the country’s largest medical-related
development – the $4.3 billion Fitzsimons Life Science District and the adjacent Anchutz Medical Campus. We are the bioscience center of the
Rocky Mountain West, offering companies access to knowledge workers, venture capital, and incubators. Not to mention an enviable lifestyle
that helps retain our highly-skilled workforce. Examine us closely at www.metrodenver.org/bioscience. You’ll find that Metro Denver is well
positioned for the future of bioscience.
TABLE OF CONTENTS
W
elcome to the Colorado BioScience
Association’s sixth edition of Bioscience
Colorado, the state’s only in depth guide and
directory to the bioscience industry. Since the
inception of the magazine, Colorado’s bioscience community has grown into an industry
cluster that combats those on the East and
West coasts. Colorado has something to be
proud of.
Within the pages of the 2010 Bioscience
Colorado magazine, you will see the faces that
make up the industry we know today. From the
serial entrepreneurs and what makes them tick
to the patients impacted by Colorado’s bioscience industry, you are sure to discover what
makes Colorado stand above the rest.
Welcome to the 2010 edition of Bioscience
Colorado magazine, we hope you enjoy it.
Produced by:
Colorado BioScience Association,
www.CoBioScience.com
Published by:
Colorado BioScience Association and
Colorado Office of Economic Development
and International Trade
20
COMPANIES TO WATCH:
Colorado’s Emerging
Life Science
Companies
24
6
The Passion That Drives
Colorado’s Bioscience
Entrepreneurs:
In Their Own Words
12
Colorado By the
Numbers:
A 2010 Update on
Colorado’s Growing
Bioscience Industry
17
Colorado Bioscience
Companies Improve The
Quality of Our Lives
Patient Profiles
In Courage
BIOSCIENCE COLORADO
2010/2011 A CLASS ACT:
Today’s Bioscience
Students
26
On The Verge
Of Greatness:
Colorado Grants
Develop Innovative
Research
33
What Colorado Can
Do For You:
Colorado’s Investments
In the Biosciences
38
CBSA 2010 Directory
5
The Passion That Drives Colorado’s
Bioscience Entrepreneurs:
SERIAL ENTREPRENEUR TREE
Orexigen
Thx
BioForce BiPharma CompleGen MicroPhage
Otsuka
Pharma
Vifor
Celgene
OSI/Pfizer
EyeTech
Archemix
GPC
Biotech
$2
Gilead
M&A
$2.5B
Myogen
IPO
Aspreva
Pharmacia
& Upjohn
Schering
M&A
All Stock
M&A
$2.9B
Abbott
Novartis
Pharmion
2000
Gilead
g
SomaLogic
M&A
915M
IPO
M& A
$189M
GSK
Baxter
M&A
$262M
Vestar
IPO
IPO
Antisoma
Nuvelo
Opthotech
Regado
Isis Pharma
Soma Logic
Nascacell
Co-Founder and/or CEO
In/Out Licensing Deals
M&A Companies
Board of Director Seat
Exit Event
1980
Noxxon
miRagen
GlaxoSmithKline
Merck Serono
Takeda
Pfizer
Merck KGaA
Synergen
Somatagen
1985
N15 Ribomic
MERGER
1990
NeXagen
Freytag
Mahaffy
Gold
6
1995
NeXstar
Amgen
2005
N15
2010
Clovis
Oncology
Clavis
Quest Dx
ARCA
GlobeImmune Biopharma BiOptix Immunicon
Flexion
Thx
2010/2011
BIOSCIENCE COLORADO
In Their Own Words
By Casey Demchak
I
t often starts with an idea
that turns into a passion that
soon becomes an obsession.
Sometimes it comes out of an
inner need to make a difference in
the world and have a positive impact
on the lives of others. However it
happens, the simple fact is this: A
lot of people dream of creating their
own business and building it into a
success—but not everybody has the
guts to do it.
To start your own business requires determination, self-discipline,
persistence, a high tolerance for
risk and a willingness to work very
long hours. And, if you’re starting a
bioscience company with the goal
of gaining FDA approval for a new
drug or medical device—it requires
an awful lot of money. Behind every
Colorado bioscience company are
men and women who’ve embraced
these challenges and took them on
with a zeal that not everyone possesses.
Dr. Larry Gold, Dr. Bill Freytag
and Patrick Mahaffy are three
well-known, and very accomplished
Colorado bioscience entrepreneurs.
Recently, CBSA sat down with all
three men to discuss their inner
drive and the thoughts and emotions
that have fueled their desire to create
successful bioscience enterprises
here in Colorado.
BIOSCIENCE COLORADO
2010/2011 DR. LARRY GOLD
Achievements: Dr. Larry Gold is the founder,
Chairman of the Board and Chief Executive
Officer of SomaLogic. Prior to SomaLogic, he
founded NeXagen, Inc., which later became
NeXstar Pharmaceuticals, Inc. During nearly
10 years at NeXstar, Dr. Gold held numerous
executive positions including Chairman of the
Board. Before forming NeXagen, Dr. Gold
also co-founded Synergen Inc., which was later
acquired by Amgen.
CBSA: Did you have an “ah ha” moment when
you just knew you had to start your own business?
LG: My ‘ah ha’ moment that I was not in conflict
with the dual goals of knowledge and business
came when I was 14 and I got my first job in
Schenectady, New York, at Imperial Shoe Salon
selling shoes in the women’s shoe department.
I’ve had so many jobs—I’ve delivered milk,
I’ve delivered newspapers; I had a job one summer in a lab and then at night I would go out
and sing in a trio that played absolutely awful
7
LG: That’s funny. I mean, we’ve had just some
stunning moments here at SomaLogic. Just a
couple of weeks ago I saw the result of a wonderful, wonderful experiment. It was this beautiful data and you knew it meant a lot, and you
knew it was going to help the company and you
knew it could help people live longer, healthier
lives. But the thrill of seeing these two fantastic
people who work here with this incredible
scientific observation is still the thing that’s so
interesting. The raw thrill of a piece of data that
maybe nobody’s ever really quite seen before
still touches me like it did in the beginning.
CBSA: What is it that really drives you when you
wake up each day?
LG: I’m driven by the same thing that every
scientist is driven by: I love the chase. I want to
be useful. We had a grant from the government;
I was paid by taxpayers to work and, you know,
that’s a privilege. You can’t have the kind of life
that I and my faculty colleagues have had without feeling grateful to a society that lets you
putz around and play, and discover these neat
things and write papers and go to meetings and
eat good food with your friends from all over.
I mean, that’s not a bad lifestyle. And so there’s
this extraordinary sense of gratitude and a need
to pay back the guy that paid you, and I bet you
that most scientists carry that. They don’t say it,
but they’ve got to carry it because you’d have to
be a moron to not be grateful.
DR. WILLIAM FREYTAG
music. You can get to be an entrepreneur in a
lot of ways, and Synergen was not motivated
by any big change in me. It was a little bit
motivated by economics—I wanted to make
enough money to send my young children to
college, and I was never going to get to do that
on my salary at the university. So it was a little
bit motivated by preservation of the values that
I cared about. It wasn’t the “ah ha” moment
you’re thinking about. I’ve been entrepreneurial
since I was a little kid. It was just in me. It felt
kind of natural.
CBSA: Did you ever have any moments of doubt
when you started Synergen?
LG: I didn’t have any doubts at all. I didn’t give a
darn. That’s what you get out of selling shoes in
a women’s shoe store. I mean, people said ‘no’
to you all the time. And I don’t mind having
people say ‘no’ to me. You can’t make me insecure because you won’t buy that pair of shoes.
And so selling is…you have to have kind of an
8
ability to say, “I think I’ll move on and we’ll try
somebody else.” Of course, you approach every
opportunity as though it’s the most important
ever, because they are. The idea is to care
deeply about each opportunity and know that
you’re going to hear a lot of people say ‘no’. It’s
all very simple.
CBSA: What kind of hours did you work to
launch your first business?
LG: When I was getting my Ph.D., I worked
probably on my Ph.D. 25 hours a week, and
then when I went to be a postdoc I started working 80 hours a week. And I’ve worked 80 hours
a week more or less my entire life right through
today. And everybody I know and respect
works all the time. The times I don’t work I
go off on a vacation with my family and read
books and enjoy my life.
CBSA: What about being an entrepreneur gives
you the most satisfaction?
Achievements: Dr. Freytag serves as a member
of the board of directors for four health care
companies: ARCA biopharma, Inc.; GlobeImmune, Inc.; ProFoldRx, Inc., and BiOptix Inc.
Dr. Freytag was Chairman and Chief Executive
Officer of Aspreva Pharmaceuticals until its
merger with Galenica AG. Prior to Aspreva, Dr.
Freytag was President, Chief Executive Officer
and Chairman of the Board of Directors of
Myogen, Inc. until it was acquired by Gilead
Sciences.
CBSA: Did you always know you wanted to be an
entrepreneur?
WF: When I was young I decided quite consciously to move into a large company environment to continue to learn as much as I possibly
could, recognizing that at an early age, coming
out of a postdoctoral study, I probably was not
going to be a good entrepreneur without a good
underpinning of what the corporate world is all
about.
2010/2011
BIOSCIENCE COLORADO
But at a young age you have dreams, and
at that time we were seeing companies like
Genentech, Amgen, Chiron and Biogen just
beginning to develop and I wanted to be a part
of that scene. And whether that meant starting
my own company or eventually running one of
those kinds of companies, that was sort of the
dream I had back then. I actually give this kind
of counsel to a lot of young entrepreneurs who
come and ask me for advice. I suggest they do
something similar to what I did, and that is go
ground yourself in the large corporate environment, because you have an opportunity to learn
so much that you can’t learn if you come out of
school and join a small company where what
you get exposed to is very limited.
CBSA: What was the shared vision among the
team that founded Myogen?
WF: We wanted to go build an important company that we believed was sustainable and made
an important contribution to healthcare. Because it’s part of our psychological mission in
life: We want to make an important contribution
to the world and we feel healthcare advances
are, indeed, something that make us feel good
about that.
CBSA: Did the idea of moving away from a
stable corporate job keep you up at night?
WF: No, because I chose not to go there. And,
something else occurred in the industry that
many of us of my age went through during the
early part of our careers—the idea of joining
a company and being with that company for a
long period of time, until you chose to leave,
was something that was sort of the foundation of the company. But in the early ‘80s,
companies started having to lay off people
for financial reasons. Suddenly the concept of
job security and the relationship between job
security at a large company and that in a startup
company became equivalent. The risk you were
taking of your own company failing was no
different than the risk you were taking of being
laid off at a large company.
CBSA: It seems these days it’s easier to create
your own job security.
WF: You’re absolutely right. And part of the
mental switch that flipped for me was at least
now my job security is in my own hands. If I’m
not successful, then my job security doesn’t
exist, but I can make my job security through
my own efforts.
CBSA: It’s always fun to ask this question: how
BIOSCIENCE COLORADO
2010/2011 many hours a week were you putting in to get
Myogen off the ground?
WF: It was all-consuming. It actually is hard for
me to say specifically how many hours a week I
worked because I worked when I came home—
so every waking hour was devoted to building
the company in some form or fashion, either
at my desk in the office or on the road raising
money or here in the evening worrying about
how I was going to address an issue going on in
the company. So easily I was spending 60, 70, 80
hours a week working for the company…but enjoying it. I mean to me it wasn’t a burden at all.
CBSA: In addition to the long hours, what was
the biggest obstacle you faced?
WF: You know some might think it’s the science.
But it’s not. The science isn’t hard because it’s
just science. You can’t predict its outcome; you
only formulate hypotheses about what you think
is going to work and then you test it. So science
isn’t hard.
So to answer your question, the hardest
thing—and I don’t think it’s unique to Myogen; it’s probably the hardest thing in every
company—was raising money. You basically
go from one financing tranche to the next, and
when you choose to do that financing is a very
challenging undertaking because you could
easily find yourself in a situation where you’re
running out of money and there’s just no money
to be raised—and it has nothing to do with you;
it has everything to do with the market. And so
trying to navigate that whole concept of market
dynamics and raising money was probably the
hardest thing we all had to do.
PATRICK J. MAHAFFY
Achievements: Mr. Mahaffy co-founded Clovis
Oncology and is its President and Chief
Executive Officer. Previously, he served in the
same role at Pharmion Corporation, which he
founded in 2000. Prior to that, Mr. Mahaffy was
9
daring
proactive
first
constructive
resourceful
excited
brilliant
amazing
befirst
ready
strong
Be First. To discover the answer or the cure, ISEC has been
supporting scientists for years. With over four decades of
experience and a global reach, ISEC understands the science and
the art of building a great facility. For more information contact
Val Ross at 303-952-5258 or [email protected].
architectural woodwork | laboratory furniture | laboratory & medical equipment
general trades | ornamental metals | specialties | doors, frames & hardware
President and Chief Executive Officer of NeXagen, Inc. and its successor, NeXstar Pharmaceuticals, Inc. Today he is also a member of the
boards of directors of Orexigen Therapeutics,
Inc. and Flexion Therapeutics, Inc.
CBSA: What was the spark that drove you to
want to co-found Clovis Oncology?
PM: I took a little time off after NeXstar and
thought about what to do next, and I found that
my thesis really was that NeXstar was a very interesting company, but we were trying to do too
much under one roof. But one of the things I
really liked that we were doing was developing
and commercializing anti-cancer drugs. I found
that to be the most rewarding and enjoyable part
of my day-to-day life at NeXstar.
So I decided that starting a company to focus
on developing and ultimately commercializing oncology drugs would play to something
I was very interested in, and of course there’s
a significant need for a company along those
lines. I think that over the course of months and
conversations with a number of people, including the co-founder at the time, Judy Hemberger,
it became an ever more attractive idea.
CBSA: Where there any doubts you had to
overcome?
PM: I don’t tend to be haunted by fears or
doubts. You know, one of the things I’ve told
people here at Clovis is, you know, we already
know it’s a really good idea. There is a real need
for a company like ours; therefore, we know
the business model’s a good idea. It’s up to us
to execute on it, and so what we spend time on
is making sure that we execute on the business model. And I just don’t find it useful to be
plagued by doubt or anxiety; better to make a
decision and follow through with it and if it’s
wrong, make another decision.
CBSA: I would think you have to have a lot of
confidence in your decision making.
PM: I think you make decisions and go down
a path, and I think you have confidence in
yourself and your team. You hire a great group
of people and you seek to control what you
can control, but waste no time worrying about
what is beyond your control. It is absolutely a
waste of energy. So it allows you to focus on
the things where you can have an influence and
usually good things happen when you do that.
CBSA: What were the biggest obstacles you
faced in developing your business?
PM: I think that at Pharmion—less so here at
10
2010/2011
BIOSCIENCE COLORADO
Clovis because the times have changed and
we’re a little more proven—there was a question about whether a company would turn over
an asset to an unproven organization with limited resources, rather than really focus on trying
to find a big pharma partner. But we were able
to gain rights to assets, one from big pharma,
one from at that time a smaller biotech company, but now a very large one because they’ve
done exceptionally well—Celgene—but I guess
that was probably a question. I mean, could we
convince somebody to bet on us? And we were
able to and things worked out pretty well.
CBSA: What about being an entrepreneur has
given you the most satisfaction?
PM: You know, I’ve been fortunate. I’ve started
companies that have had a good outcome. And
building a company is enormously rewarding.
I’ll give an example of something that just feels
great: I was at ASCO last year around the time
we started Clovis, and I went to the session on
MDS, which is a type of leukemia that our drug
at Pharmion, Vidaza®, treated exceptionally
well. And at the session, the presenter, who was
not involved in our clinical trial, said, “Now let
me turn to a trial that I think is not only the best
trial that’s ever been done in MDS, but probably
the best trial done in leukemia—in any type of
leukemia—in the last five or 10 years,” and it
was our trial.
It was a survival trial we ran to demonstrate a very significant survival advantage for
Vidaza®. And it’s tremendously rewarding to
think not only did we start a company—but
what I always tell people is, “All we want to do
is matter.” If we do our job right, if we matter in
the patients’ lives, then good things are gonna
happen. And that trial is a good example of a
very difficult trial, a very well-designed and
managed trial, and the outcome was superb
for patients…and it feels great. It feels great to
create a company; it feels particularly great to
create a company that matters.
CBSA: When you get up in the morning, what
really drives and motivates you?
PM: You know, when you start a company as
I’ve done in the past six months with Clovis,
and in this case with $145 million of other
people’s money, you make a deal with them that
you are going to do your damndest to give them
a return on that investment. It’s not a gift. So,
one goal is to provide a return for the people
who bet on me. Two is to provide a great environment for the people that work for me. Three
is to gain access to products, as we’ve begun
to, and be responsible for developing them in
a responsible way in the hopes that we are, as
a company, going to make a real difference in
patients’ lives. And at some level, all of this
relates to the fact that drug development is one
of the great team sports. I mean, it’s a tremendous challenge; multiple interdisciplinary teams
have to be coordinated to work together in order
to bring a product forward. And I find this challenge to be enormously interesting.
CBSA thoroughly enjoyed our 20-minute
discussions with Dr. Larry Gold, Dr. William
Freytag, and Patrick Mahaffy. Their insights
into the drive and passion required to start
and build successful bioscience enterprises is
an education for any who might wish to follow
in their paths. To read full transcripts of our
extended interviews with these three bioscience
pioneers, we invite you to visit www.cobioscience.com.
Sprint Denver specializing in
for the BioScience and Pharmaceutical Community.
Sprint Denver is your single source provider for all your print communication
needs. Our focus in producing print for the BioScience, Pharmaceutical
fields means we have the resources and knowledge to help you communicate
your message efficiently and effectively to your customers.
Photo: Don Eastburn, Castle Rock, CO
All Rights Reserved
Contact us and learn what makes Sprint Denver your best choice in print.
Contact Michael Ehrman
[email protected]
4999 Kingston Street, Denver, CO 80239 303.371.0566 sprintdenver.com
The Sprint Denver 2009 Green Report is available, please contact Michael Ehrman for your emailed copy.
BIOSCIENCE COLORADO
2010/2011 11
Colorado By the Numbers:
A 2010 Update on Colorado’s
Growing Bioscience Industry
By ADAM RUBENSTIEN
T
o say the previous year was a trying time for
individuals and companies is an understatement, but taking a quick glance at the Colorado Bioscience ecosystem via the following
maps outlines an industry that not simply has
endured the turbulence but has, on a relative basis,
thrived throughout the last twelve months.
Certainly some entities were faced with having
to close the doors but that comes with the territory
where one in ten thousand new molecular entities
ever reach the market. Over $400M flowed into
Colorado bioscience companies in 2009 in the form
of institutional and angel financings, secondary
issues and milestone payments. These Companies
also reflect the diversity of the Colorado bioscience
industry as capital flowed in to fund work in the
biopharma, medical device, diagnostic, green-bio
and medical-IT sectors. Since the CBSA began
tracking Colorado bioscience financings over $1.1
billion in capital has been injected into the State
and over an additional $6.8 billion has been created
in shareholder value via a number of M&A events
from a who’s who of big pharma; with the most
recent 2009 acquisition of Boulder-based Insmed
(Biologics Manufacturing) by Merck.
The leadership in Colorado also recognizes the
importance of catalyzing early-stage intellectual
property. So with the recent passage of House Bill
1001 allocating more than $25M to early-stage life
science IP in concert with the newly established
Colorado Institute for Drug, Device and Diagnostic Development (http://www.cid4.com) and
the growth of the Colorado Initiative in Molecular
Biotechnology (http://cimb.colorado.edu) and the
NeoTrex Cancer Supercluster (http://superclusters.
colostate.edu) the seeds are being planted for a
robust pipeline of downstream Colorado company
formations and subsequent financing events that
will keep the Colorado Bioscience ecosystem thriving for years to come.
12
colorado growth map 2006-2009
Technology Legend
New Companies since 2006/07
Recent Institutional Financing
Public Companies
Larimer
22
28
33
48
Weld
25
27
Boulder
13
1
2
12
9
8
11
26 11
15
43 28 20
9 7
32
Broomfield
Gilpin
3
Clear Creek
14
10
32
20
40
6
37
12 34 21
33
41
35 45 46
Adams
44 47
Denver
Arapahoe
38
Jefferson
42
Elbert
Douglas
Colorado
Teller
San Miguel County,
Telluride, CO
37
Middlesex County
Hopkinton, MA
El Paso
2010/2011
BIOSCIENCE COLORADO
colorado growth map 2006-2009
1 3Q Matrix
2 A2BE Carbon Capture
3 Accuthera
4 Advanced Headache
Intervention
5 Advanced Microlabs
6 ApopLogic Pharmaceuticals
7 ArcScan Inc.
8 Beacon Biotechnology
9 BioAMPS International
10 Biodesix
11 BlueSun
12 Caveo Therapeutics
13 Chemizon
14 Clarimedix
15 CycleGen
16 EndoShape
17 FireFly Medical
18 Fluonic
19 HepQuant
20 Hiberna
21 Illumasonix
22 KromatidTiD
23 Lanx
24 Locomotion
25 mBio Diagnostics
26 Miragen Pharmaceuticals
27 OPX Biotechnologies
28 Peak Biosciences
29 pico-tesla Magnetic
Therapies
30 Precision Biopsy
31 Sierra Neuropharmaceuticals
32 Snoasis Medical
33 Solix Biofuels
34 Taiga Biotechnologies
35 Tissue Genetics
36 ValveXchange
37 V-Clip Pharmaceuticals
38 Ventrus Biosciences
39 Vitrumed
40 MycoLogics
41 AmideBio
42 Analytical Research System
43 InDevR
44 Qgenta
45 Allogenesis
46 Western States Biopharma
47 Isogenis
48 Tolmar
49 Biotricity Medical
BIOSCIENCE COLORADO
2010/2011 Weld
Larimer
17
28
22
5
33
49
48
25 13
28
1
Boulder 2
9
14
26 16 1511 10
23
43
24 20
Broomfield
40
39
Gilpin
27
18
6
12 348
3
Clear Creek
Middlesex County
Hopkinton, MA
7
Jefferson
32
Denver
38
4
19 35 45 46
30
Adams
21 3136 44 47
41
29
42
Arapahoe
Technology Legend
Medical Device
Biopharma
Diagnostic
Douglas
GreenBio
Other
37
El Paso
13
Institutional Financings 2007 to Present
COMPANY ROUND/EVENT VALUE ($M)
1 Accera Series C $ 35.0
2 Allos Therapeutics Secondary $ 65.2
Allos Therapeutics Secondary $ 50.5
3 ARCA biopharma Series B $ 18.0
4 Array Biopharma Debt + Warrants $ 80.0
5 Aspen BioPharma S
econdary $ 18.2
6 BaroFold Series A $ 12.0
7 Biodesix Series B Undisclosed
8 BiOptix Series B Undisclosed
9 CeraPedics Series A financing $ 12.3
10 Evolutionary Genomics Series A $ 5.0
11 GlobeImmune Series C $ 41.2
12 iBalance Medical Series A $ 13.5
13 Illumasonix Series A Undisclosed
14 Lanx Series A $ 25.0
15 MD-IT Series B $ 11.0
16 Microphage Series A $ 11.0
17 Miragen Series A $ 8.0
18 N30 Pharma Series A Undisclosed
19 OPX Biotechnologies Series A $ 3.6
20 OberonFMR Series A $ 1.0
21 Precision Biopsy Series A Undisclosed
22 Range Fuels Series B $ 130.0
23 Sierra Neuropharma Series A $ 21.5
24 SomaLogic Series D $ 35.0
25 Taligen Therapeutics Series B $ 65.0
26 TheraTogs Series A $ 1.1
27 Luca Technologies Series C $ 76.0
28 Medivance Series E $ 8.1
29 Clovis Oncology Series A $ 146.0
30 OPX Biotechnologies Series B $ 17.5
31 CeraPedics Series B $ 14.5
32 BiOptix Series A $ 3.0
33 AmideBio Seed Undisclosed
34 GlobeImmune Series E $ 17.5
35 GlobeImmune Milestone payment $ 40.0
36 Inviragen Series A $ 15.0
37 Sharklet Series A $ 1.5
38 miRagen Series A2 $ 4.0
39 Array Biopharma Debt + Warrants $ 40.0
40 BioAMPs Seed $ 0.1
41 Allos Therapeutics Secondary $ 93.0
42 AspenBio Pharma Secondary $ 8.7
Sub-total | Capital Raises $1,720.0
Acquired 43Dharmacon 44Sirna Acquired 45Pharmion Acquired 46Myogen Acquired 47RxKinetix Acquired 48 Insmed Acquired Sub-total | Exits TOTAL | Capital infused to Colorado 14
$ 80.0
$ 1,100.0
$ 2,900.0
$ 2,500.0
$ 115.0
$ 130.0
$6,825.0
$7,997.0
Larimer
Weld
36
Technology Legend
Medical Device
Biopharma
30 11 43 45 38 16
Diagnostic
6 24 15
46
17 10
GreenBio
31
Boulder 12
Other
4
14
32
8
19 29
3
1
11 18
22
34 48 44 47
28 39
9 7
2
41
Broomfield
25
Gilpin
23 13 37
21 Adams
40
10
33
1
27
11
20
Denver
35
Jefferson
39
42
Teller
12
22
5
Arapahoe
Elbert
Douglas
El Paso
Colorado
26
San Miguel County,
Telluride, CO
2010/2011
BIOSCIENCE COLORADO
Larimer
Weld
19
31
Technology Legend
Colorado-Based and Related
Medical Device
Biopharma
32
23
5
27 25
Boulder 28 15
33
29
Diagnostic
4
GreenBio
Other
20
34
2
14
24 17
7
21 Broomfield
30 16
3
Gilpin
18
10
26
1
Adams
40
11
Denver
38
Jefferson
12
22
13
39
41
Arapahoe
8
Elbert
Douglas
Teller
36
9
BIOSCIENCE COLORADO
2010/2011 El Paso
1
2
3
4
Colorado-Based
& Related Public CompaPublic Companies
nies
Accelr8 Technology
Agilent Technologies
Allos Therapeutics
Alpharma Animal Health/
King Pharma
AMEX: AXK
NYSE: A
NASDAQ: ALTH
NYSE: KG
5 Amgen
7 Array Biopharma
8 AspenBio Pharma
9 B2 Health
10 BioNovo
11 Ceragenix Pharmaceuticals
12 Cochlear Americas
13 Conmed
14 Corgenix Medical
15 Covidien
16 Dharmacon/
Thermo Fischer Scientific
NASDAQ: AMGN
NASDAQ: ARRY
NASDAQ: APPY
NASDAQ: BTWO
NASDAQ: BNVI
OTC BB: CGXP.OB
ASX: COH
NASDAQ: CNMD
NASDAQ: CONX.OB
NYSE: COV
NYSE: TMO
17 Encision
18 GeneThera
19 Heska
20 Hospira
21 InB:Paxis / Hauser CRO/
Integrated BioPharma
NASDAQ: ECIA.OB
NASDAQ: GTHR.PK
NASDAQ: HSKA
NYSE: HSP
NASDAQ: INBP
22 Inhibiton Therapeutics
23 Insmed
24 Martek Biosciences
25 Medtronic
26 Mesa Labs
27 Myogen/Gilead
28 OrthoNextx
29 OSI Pharmaceuticals
30 Pharmion/Celgene
31 QLT
32 Replidyne/
CardioVascular Systems
NASDAQ: IHBT
NASDAQ: INSM
NASDAQ: MATK
NYSE: MDT
NASDAQ: MLAB
NASDAQ: GILD
NASDAQ: ANTX.OB
NASDAQ: OSIP
NASDAQ: CELG
NASDAQ: QLTI
NASDAQ: RDYN
33 Roche Colorado
34 Sandoz
36 Spectranetics
38 The Sorin Group
39 VitroLife
40 Xelr8 Holdings
41 Zynex
VTX: ROG.VX
NYSE: NVS
NASDAQ: SPNC
MTAX: SRN.MI
SEK: VITR
AMEX: BZI
NASDAQ: ZYXI.OB
15
Colorado Recent Financings January 2010
n Green-Bio n Biopharma n Medical Device n Diagnostic n Other
COMPANY
CITY/ZIP
ROUND/EVENT
VALUE ($M)
TECHNOLOGY/PRODUCT
1 Accera
Broomfield / 80021
Series C
$35.00 Medical Foods | CNS 2 Allos Therapeutics
Westminster / 80020
Secondary $65.20 Small molecule THx | Oncology
3 Allos Therapeutics
Westminster / 80020
4 ARCA biopharma
Broomfield / 80021
Series B
$18.00 Small moleculer THx | Cardiovascular
5 Array Biopharma
Boulder / 80301
Debt + Warrants
$80.00 Small molecule THx | Oncology
7 Aspen BioPharma
Castle Rock / 80104
Secondary $18.20 Protein THx and Dx | Reproduction, Appendicitis
8 Arterain Medical
Atlanta / 30313
Series A
Undisclosed
9 BaroFold
Boulder / 80301
Series A
$12.00 Protein THx | Immunologic disorders
10 Biodesix
Broomfield / 80021
Series B
Undisclosed Dx Platform | Oncology
11 BiOptix
Boulder / 80301
Seed
Undisclosed Dx Platform | Infectious Diesease
12 Ceragenix
Denver / 80202
Milestone payment
$1.00 Medical Device | Infectious Disease
13 Ceragenix
Denver / 80202
Milestone payment
$1.50 Medical Device | Infectious Disease
14 CeraPedics
Broomfield / 80021
Series A
$12.30 Medical Device | Bone Graft
15 Evolutionary Genomics
Lafayette / 80026
Series A
$5.00 Biofuels Greentech
16 GlobeImmune
Louisville / 80027
Series C
$41.20 Discovery and development of potent,
targeted molecular immunotherapies
17 iBalance Medical
Boulder / 80301
Series A
$13.50 Medical Device | Orthopedic
18 Illumasonix
Aurora / 80045
Series A
Undisclosed Dx Platform | Cardiovascular
19 Lanx
Broomfield / 80021
Series A
20 MD-IT
Boulder / 80301
Series B
$11.00 Telemedicine | Electronic Records
21 MedShape Solutions
Atlanta / 30318
Series A
Undisclosed
22 Microphage
Longmont / 80503
Series A
$11.00 Dx Platform | Infectious Diesease
23 miRagen
Boulder / 80301
Series A
$8.00 miRNA | Cardiovascualr
24 N30 Pharma
Boulder / 80301
Series A
Undisclosed Small molecule THx | Respiratory
Boulder / 80301
Series A $3.60 Biofuels Greentech
26 OberonFMR
Idaho Springs / 80452
Series A $1.00 Biofuels Greentech
27 Precision Biopsy
Aurora / 80045
Series A
Undisclosed Dx Platform | Oncology
28 Range Fuels
Broomfield / 80021
Series B
29 Sierra Neuropharma
Aurora / 80045
Series A
$21.50 Small molecule THx | CNS
30 SomaLogic
Boulder / 80301
Series D
$35.00 Dx Platform | Various Diseases
31 Taligen Therapeutics
Aurora / 80045
Series B $65.00 Protein THx | Inflammation
32 TheraTogs
Telluride / 84135
Series A
33 Luca Technologies
Golden / 80401
Series C
34 Medivance
Louisville / 80027
Series E
$8.10 Medical Device | Temperature Management
35 AspenBio Pharma
Castle Rock / 80104
Secondary $8.70 Protein THx and Dx | Reproduction, Appendicitis
36 Clovis Oncology
Boulder / 80301
Series A
Boulder / 80301
Series B
38 CeraPedics
Broomfield / 80021
Series B
$14.50 Medical Device | Bone Graft
39 BiOptix
Boulder / 80301
Series A
$3.00 Dx Platform | Infectious Disease
40 AmideBio
Aurora / 80045
Seed
Undisclosed Biopharma | Peptide Manufacturing
41 GlobeImmune
Louisville / 80027
Series E
$17.50 Biopharma | Oncology and Infectious Disease
42 GlobeImmune
Louisville / 80027
Milestone payment
$40.00 Biopharma | Oncology and Infectious Disease
43 Inviragen
Ft. Collins / 80525
Series A
$15.00 Biopharma | Vaccines for Infectious Disease
44 Sharklet
Aurora / 80045
Series A
$1.50 Antimicrobial Surface Film
45 miRagen
Boulder / 80301
Series A2
$4.00 miRNA | Cardiovascular
46 Array Biopharma
Boulder / 80301
Debt + Warrants
47 BioAMPs
Aurora / 80045
Seed
$0.10 Biopharma | Infectious Disease
48 Allos Therapeutics
Westminster / 80020
Sub-total | Capital Raise 2009
$408.90 Sub-total | Capital Raise Inception
$1,172.00 49 Dharmacon
Lafayette / 80026
Acquired
$80.00 RNAi oligos
50 Sirna
Boulder / 80301
Acquired
$1,100.00 RNAi THx | Oncology
51 Pharmion
Boulder / 80301
Acquired
$2,900.00 Small molecule THx | Oncology
52 Myogen
Boulder / 80301
Acquired
$2,500.00 Small molecule THx | Cardilogy
53 RxKinetix
Louisville / 80027
Acquired
54 Insmed
Acquired
$130.00
Sub-total | Exits
$6,825.00
TOTAL | Capital infused to Colorado
$7,997.00
16
2010/2011
BIOSCIENCE COLORADO
Colorado Bioscience Companies
Improve The Quality of Our Lives
Patient Profiles In Courage
By: Casey Demchak
I
f you follow the Colorado bioscience
industry on a daily basis, it can be easy
to forget the impact it has on people’s
lives. News articles and cocktail party
discussions often center on an array of buzz
phrases such as, venture capital, mergers and
acquisitions, job creation, economic impact,
breakthrough science and preclinical trials.
These topics are all of great significance,
but ultimately there is one subject within the
Colorado bioscience community that stands
above the rest: the tremendous positive contribution our industry has on lives throughout
the world.
People in all corners of the planet wake
up every day with a renewed sense of hope
because of the work being done right here in
Colorado. It’s about the woman who can go on
a 100-mile bike ride today, thanks in part to a
drug that kept her energy and spirits up during
her chemotherapy infusion treatments following breast cancer surgery.
It’s about a young, innocent boy who can
now play video games and look forward to
the day when he can eat solid foods—like the
other kids—because a medical device made by
a Colorado company played an important role
in his bone marrow transplantation.
Every day, people we’ll never meet are
better able to enjoy time with their loved ones,
take a walk along a beach or simply use the restroom without pain and discomfort due to the
dedication and unending hours of work being
done by bioscience professionals throughout
our state.
Here are two stories of courageous patients
whose quality of life has been raised by Colorado bioscience companies.
BIOSCIENCE COLORADO
2010/2011 WILL CRISLER
In June, 2008 Will Crisler’s young life
changed in ways he and his parents could
never have imagined. A normal nine-year
old boy, he had what seemed like a typical
nose bleed one day in his home town of
Albuquerque, New Mexico. However, when
his nose bleed persisted for more than an
hour, Will’s parents called their family
doctor, who advised them to take Will to the
emergency room immediately.
At the hospital it was discovered that his
nose bleed was anything but typical. Will
also had a low fever, bleeding gums and legs
covered in bruises. After an examination and
several tests, Will’s parents learned their son
had severe aplastic anemia – a condition where
a patient’s bone marrow doesn’t produce an
adequate amount of blood cells. In fact, upon
diagnosis Will’s bone marrow was providing a
mere 5% of his own cells.
17
No one in their family had ever been diagnosed with a severe illness, so Will’s diagnosis
hit them hard. Will soon received his first
blood transfusion, and has since received over
130 of them.
Soon after, Will began receiving treatments at The Children’s Hospital in Denver.
His parents had to take turns staying with him
in Colorado, while also staying with Will’s 15
year-old sister in Albuquerque. Initially, Will
and his family stayed at a hotel close to The
Children’s Hospital, but the hotel became too
expensive and was not clean enough for Will’s
weak immune system. This obviously wasn’t
an ideal environment for Will.
However, things changed dramatically for
the better when Will was able to move into
Brent’s Place, which is a five minute drive
from Denver’s The Children’s Hospital. Brent’s
Place is a non-profit organization providing
safe, clean apartments designed to protect patients with immune-compromising conditions.
It functions as a convenient “home away from
home” for children with cancer and their families, providing immune-compromised patients
with an ideal healing environment after bone
marrow or stem cell transplantations.
A recent corporate sponsor of Brent’s Place
is Denver-based CaridianBCT, which is a leading global provider of blood technologies and
services to blood centers, hospitals and scientific, clinical and biotech researchers. Because
Brent’s Place offers housing for children with
compromised immune systems, many children
benefit from CaridianBCT’s technological innovations in the medical device industry.
The medical devices CaridianBCT
manufactures in Denver have played a crucial
role in Will’s treatments. When Will’s body
stopped responding to traditional treatments,
it was determined a bone marrow transplant
was the only procedure that could save his
life. Fortunately, Will’s father, Chuck Crisler,
was a matching donor. About six months ago,
18
Chuck was able to give Will a bone marrow
transplant.
Upon harvesting Chuck’s stem cells, CaridianBCT’s COBE® Spectra Apheresis system
was used in the treatment of Chuck’s cells
prior to transplanting into Will. Chuck’s lifesaving bone marrow was then given to Will so
it could “jumpstart” his system into making its
own blood cells again. As a result, Will is now
able to produce over 30% of his own cells.
Chuck Crisler is nothing less than amazed
with the innovative technology that saved his
son. “Thirty years ago, this diagnosis would
have likely meant that Will would have died,”
says Chuck. “I am so grateful for CaridianBCT’s technology and how it has kept my son
alive.”
At CaridianBCT, the focus remains on the
patients they ultimately serve, and that’s why
they are so proud to know that their technology has helped Will through the treatment and
recovery of his aplastic anemia. Partnering
with Brent’s Place in their quest to serve kids
with cancer, CaridianBCT is thrilled to be a
silver-level sponsor with the organization –
furthering their mission For Better Blood and
Better Lives. They look forward to supporting
and participating in the Brent’s Place annual
5Kwalk/run charity event this summer on July
10th.
To learn more about Brent’s Place and how
you can contribute to this important cause, we
encourage you to visit their website at www.
brentsplace.org.
DIANE GROFF
Running 10K’s and bike riding across Iowa
was considered a normal excursion for Diane
Groff who had always lived an extremely active and healthy lifestyle. There was no history
of breast cancer in her family, so at age 41
it came as a complete shock to Diane when
cancer was detected in her left breast.
Fortunately, it was a Stage 0 diagnosis, and
Diane had a lumpectomy and 25 days of radiation treatments. Naturally, she cycled to all of
her treatments, completing her final “radiation
day” with a 60-mile ride through the Front
Range foothills.
Diane’s mammograms showed no signs of
concern for over two years. However, in the
fall of 2001, a second primary bilateral breast
cancer was found in her right breast. This time
2010/2011
BIOSCIENCE COLORADO
it was an invasive Stage II diagnosis, and Diane chose to have a bilateral mastectomy and
breast reconstruction procedures.
In addition to four surgeries, Diane had
to endure 12 weeks of chemotherapy treatments. During this period it was crucial that
she maintain her health and keep her energy
up as much as possible. To accomplish this,
in between chemotherapy treatments Diane
would receive an injection of Epogen®, which
is a red blood cell booster shot.
Epogen® is a product developed by Amgen, a leading human therapeutics company
within Colorado’s bioscience industry. Amgen
has pioneered the development of novel products based on advances in recombinant DNA
molecular biology. As a Fortune 500 company
that serves millions of patients, Amgen has
always been a science-driven company dedicated to helping people fight serious illness.
What instantly tied Diane and Amgen
together is that they are both Longmont,
Colorado, residents. “I was able to bike ride to
all my Epogen® injection appointments,” said
Diane. “I would ride straight west, turn left
and yell out ‘Thank you!’ as I bicycled past
Amgen.”
Diane also noted, “What Epogen® did for
me was keep me on my chemotherapy schedule, and that was of huge importance.”
Being a 28-year resident of Longmont,
Diane had watched Amgen develop over the
years, so she felt a special connection to them
during her chemotherapy and Epogen® treatments. That connection further solidified three
years later when Diane went to a local community function that was attended by Amgen
representatives, including Jessica Graziano,
who is Amgen’s Senior Associate, Corporate
Communications.
“I asked Jessica if she had ever met someone who had used an Amgen product,” reports
Diane. “She said she never had, so I told her
my story and that’s how my connection with
Amgen began.”
That chance connection with Jessica
Graziano has led to Diane Groff being an
inspirational speaker at Amgen training meetings and retreats. In turn, Amgen has funded
finish line celebrations for Diane’s Rocky Mt.
Team Survivor triathlon events.
“It always brings a smile to my face when
I see the Amgen sign up at an event,” says
Diane. “They are also big supporters of the
American Cancer Society Relay For Life, and
I very much appreciate that.”
Only three weeks after her last chemoBIOSCIENCE COLORADO
2010/2011 therapy treatment, Diane Groff ran a 5K, a
race that she still calls the most significant
race of her life. Competing in triathlons and
running events as an active cancer survivor is
an unending source of joy and hope for her.
Diane has been cancer free for five years and
continues to lead a very active life. In fact, she
is now a sponsored athlete through the Brooks
Running Company Inspire Daily program, and
a proud member of Team Survivor. To learn
more about Diane Groff’s amazing journey,
please visit her inspiring web site at www.
dianegroff.net.
These two profiles show the courage of
patients who have benefited from the Colorado
bioscience community, but only represent two
out of hundreds of thousands of stories across
the globe.
It’s important for all of us to never forget
that beyond the quests for venture capital and
scientific breakthroughs lie the hopes and
dreams of real people whose quality of life
has been forever improved though the hard
work and vision of those who have put their
heart and soul into shaping the landscape of
Colorado’s bioscience industry.
19
COMPANIES TO WATCH:
COLORADO’S EMERGING
LIFE SCIENCE COMPANIES
BY ADAM RUBENSTEIN
A
significant temporal duration exists,
at times exceeding a decade or more
between idea-generation, clinical studies and commercialization. Gaps and
valleys and troughs are often used to describe
capital needs based upon where a company or
technology sits on the development continuum. In Colorado, the cowboy spirit and can-do
attitude permeates throughout the entrepreneurial ecosystem where biopioneers find
themselves embarked upon sometimes unique
paths to get their products to market, and in
doing so, may often fly under the radar relative
to others who have closed well publicized
institutional financings.
Here we turn the spotlight on a few
of those companies. Colorado is home
to a diverse array of bioscience sectors
featuring the development of not only
biopharmaceuticals, devices and diagnostics
but home to also emerging green-bio and
medical-IT products and technologies. What
follows are some of Colorado’s most exciting
emerging companies representing products
and technologies from all sectors of the
bioscience industry.
20
COMPANY: MICROPHAGE
SECTOR: BIO-DX
CEO: STEVE LUNDY
LOCATION: LONGMONT, CO
WEB: MICROPHAGE.COM
Based in Longmont, Colorado, privately
held MicroPhage is focused on achieving a
global leadership position in developing rapid,
easy-to-use diagnostic products for bacterial
identification and antibiotic susceptibility
and resistance testing. Using their proprietary
Bacteriophage Amplification platform, the
Company has developed a patented process
that is a product platform for rapid, easy-touse, inexpensive diagnostic and screening
tests. The platform does not require any
instrumentation and is simple to operate,
enabling microbiology testing outside of
traditional laboratory settings.
The company has chosen to focus their
initial efforts to help solve medical crises
involving such problems as over use of
antibiotics and antibiotic resistant bacteria.
The first product expected in 2010 is
anticipated to set a new standard for clinicians
and hospital staff in methicillin-resistant
Staphylococcus aureus (MRSA) identification
and antibiotic testing. Additional bacterial
pathogens that may be addressed with the
company’s technology include: Vancomycinresistant Enterococcus (VRE), ESBLproducing Escherichia coli, drug resistant
Pseudomonas aeruginosa, and penicillinresistant Streptococcus pneumoniae.
2009 proved to be an exciting year for
CEO Steve Lundy and company as a number
of important milestones were achieved,
including: launching their multi-site clinical
trial to support a FDA premarket notification
[510(k)]; obtaining a CE Mark to market in
Europe the first of their instrument-free tests
designed to rapidly identify Staphylococcus
aureus bacteria as well as determine
methicillin resistance or susceptibility in
suspected cases of bacteremia; and, announced
a doubling of their office and laboratory space
while increasing full time employees from 4
to 25. Look for MicroPhage to conclude their
pivotal study to support their 510(k) premarket
notification and initiate commercial operations
in the first half of 2010.
COMPANY: SOURCE MDX
SECTOR: BIO-DX
CEO: KARL WASSMAN
LOCATION: BOULDER, CO
WEB: SOURCEMDX.COM
Based in Boulder, Colorado, Source MDx
is developing and commercializing prognostic,
predictive and early detection molecular
diagnostic (Precision Profile™) assays and
tests for cancer and other inflammatory
diseases. The Company’s lead development
programs, in collaboration with the DanaFarber Cancer Institute, include a family of
Precision Profile™ assays for prostate cancer
designed to: i. improve early diagnosis with a
goal to reduce the need for biopsies, ii. predict
the aggressiveness of the cancer, and iii. better
define prognosis and more effectively stratify
patients for drug response - all of which may
serve to improve the management of patient
care and lower healthcare costs.
The Company is also developing molecular
diagnostics in collaboration with other leading
2010/2011
BIOSCIENCE COLORADO
based on the discovery, characterization and
management of naturally occurring consortia
of ancient, anaerobic microorganisms that
metabolize oil, organic-rich shale and
coal within the earth into natural gas, thus
generating clean renewable energy in a
continuous, “real time” fashion. Luca employs
genomics, molecular biology and other tools
of biotechnology to detect, classify and
study these organisms and the underground
“Geobioreactors” in which they act.
2009 proved to be a very exciting year
for the Luca team assembled by CEO Robert
Pfeiffer, for in addition to having received a
key notice of allowance by the US Patent and
Trademark Office covering the Company’s
technology for microbially enhanced methane
production, Luca was also named to the Global
Cleantech 100 list by the Guardian News and
Cleantech Group. Supported by the Carbon
Trust, the Global Cleantech 100 recognizes
companies at the forefront of cleantech
innovation offering solutions to some of
the world’s most pressing environmental
challenges. Luca was also selected by
AlwaysOn as one of the GoingGreen Top 100
Winners, with the selection based upon a set
of five criteria: innovation, market potential,
commercialization, stakeholder value and
media buzz.
COMPANY: OPX BITECHNOLOGIES
SECTOR: BIO-GREEN
CEO: CHARLES EGGERT
WEB: OPXBIOTECHNOLOGIES.COM
academic medical centers in a range of cancers,
including lung and melanoma, as well as certain
inflammatory and autoimmune diseases such
as multiple sclerosis. Source MDx’s patented
assays and tests measure RNA-transcriptbased gene expression in whole blood using
quantitative PCR, optimized for clinical use
in a commercial setting. The Company has a
multi-year translational molecular medicine
collaboration with Pfizer to develop and
validate RNA-based pharmacodynamic and
predictive biomarkers within Pfizer’s cancer
and inflammation therapeutic development
programs. Led by CEO Karl Wassman, Source
MDx has worked with more than 30 major
pharmaceutical firms on over 150 preclinical
projects and clinical trials that have involved
over 5,000 human subjects.
BIOSCIENCE COLORADO
2010/2011 COMPANY: LUCA TECHNOLOGIES
SECTOR: BIO-GREEN
CEO: ROBERT PFEIFFER
LOCATION: GOLDEN, CO
WEB: LUCATECHNOLOGIES.COM
Based in Golden, Colorado, Luca
Technologies is developing a novel, longterm, biotechnology-driven solution to rising
US dependence on foreign energy sources.
Addressing the $150 billion domestic natural
gas market, the company is leveraging the
ability of naturally occurring microorganisms
to convert under-utilized domestic oil,
organic-rich shale and coal resources to clean,
renewable energy. The company’s business
is characterized by: A technology platform
Based in Boulder, Colorado, OPX
Biotechnologies is a bio-products company
using proprietary bioengineering technology to
convert renewable feedstocks into biofuels and
green chemistry products. The OPX EDGE
(Efficiency Directed Genome Engineering)
technology platform enables rapid, rational,
and robust optimization of microbes and
bioprocesses. The Company identifies the
genes that control microbial metabolism and
then implements a comprehensive, rational
genetic change strategy to simultaneously
optimize microbial production pathways
and vitality as well as overall bioprocess
productivity.
The OPX platform includes a first-of-itskind, massively parallel, full genome search
technology known as SCALEs. The OPX
EDGE technology is 1,000 to 5,000 times
faster than conventional genetic engineering
21
methods, meaning OPX creates optimized
microbes and bioprocesses within months
rather than years. Compared to petroleum-based
alternatives, OPX EDGE bioprocesses deliver
equivalent product performance with improved
sustainability at lower cost. Using the EDGE
platform, OPX has produced multiple biofuel
and green chemistry products at laboratory
scale from several different renewable
feedstocks. OPX is proving its economical
bioprocesses at larger scale in advance of a
demonstration plant startup in 2011.
COMPANY: MIRAGEN THERAPEUTICS
SECTOR: BIO-PHARMA
CEO: BILL MARSHALL
WEB: MIRAGENTHERAPEUTICS.COM
Based in Boulder, CO miRagen
Therapeutics, a development-stage
biopharmaceutical company is focused on
developing innovative microRNA (miRNA)
based therapeutics for cardiovascular and
muscle disease. The Company is leveraging
its core capabilities in miRNA profiling,
oligonucleotide medicinal chemistry, cellular
analysis, and in vivo testing in disease
models to select highly potent modulators
that target lead miRNAs in disease-specific
pathways. miRagen has identified miRNA
signature expression patterns associated
with pathological cardiac hypertrophy, heart
failure and myocardial infarction in humans
and mouse models of heart disease, as well
as discovering miRNAs that are important
in vascular and skeletal muscle disease. The
Company has validated numerous targets and
moved potential clinical candidates through
lead optimization into IND-enabling preclinical studies.
2009 has proven to be a very fruitful year
for CEO William Marshall and the entire
team at miRagen, a few highlights include:
Chief Scientific Advisor and Co-Founder,
Eric Olson, Ph.D., was awarded Grand
Prize of the Institute de France’s Foundation
Lefoulon-Delalande, widely considered the
most distinguished prize in the cardiovascular
field, for his groundbreaking research into
the mechanisms of gene regulation in heart
development; a collaboration Archemix was
announced to jointly pursue research and
development efforts on aptamer-microRNA
therapeutics; was awarded, by the Colorado
BioScience Association, the 2009 Rising Star
of the Year Award, recognizing a Colorado
22
life sciences company that has demonstrated
itself as “one to watch.”; and, published data
in the journal Science demonstrating, in mice,
that microRNA-206 plays a crucial role in the
progression of amyotrophic lateral sclerosis
(Lou Gehrig’s disease) and in neuromuscular
synaptic regeneration.
COMPANY: WESTERN STATES
BIOPHARMA
SECTOR: BIO-PHARMA
CEO: MICHAEL REILLY
LOCATION: AURORA, CO
WEB: WESTERNSTATESBIOPHARM.COM
Based in Aurora, Colorado, Western
States Biopharmaceuticals is a privately-held
company focused upon the development of
novel, small molecule and biologic therapeutic
approaches that selectively modulate adaptive
immunity to treat inflammatory diseases.
By focusing on activated macrophages, a
key white blood cell in the adaptive immune
system, Western States is designing drugs that
target the pathogenesis of autoimmune disease
while avoiding suppression of the innate
immune system. The goal of Western State’s
drug discovery and development research
programs are to identify human CD4+ T-cell
and macrophage proteins that mediate adaptive
immunity but leave the innate immune system
intact. The Company refers to these novel
human T-cell proteins as “T-cell Cytokine–
Inducing Surface Molecules”, or TCISM.
Western States has recently shown that two
important human TCISM are upregulated upon
CD4+ T-cell activation and physiologically
associate at the T-cell membrane surface.
T-cell driven macrophage cytokine levels
were decreased by 90-100% when expression
was simultaneously inhibited by dual siRNA
knockdown for both T-cell proteins.
2009 proved to be an important year not
only for the demonstration of certain TCISM
candidates but Scientific Advisory Board member Charles Dinarello was awarded three significant prizes, including: the Crafoord Prize in
Polyarthritis by the Royal Swedish Academy of
Sciences, for pioneering work to isolate interleukins, determine their properties and explore
their role in the onset of inflammatory diseases;
the Albany Medical Center Prize in Medicine
and Biomedical Research, for groundbreaking work on anti-cytokine therapies that block
the immune system’s inflammatory reaction;
and, the Paul Ehrlich and Ludwig Darmstaedter Prize, for his outstanding contributions to
research in the field of cytokines.
COMPANY: VALVEXCHANGE
SECTOR: MED-DEVICE
CEO: LARRY BLANKENSHIP
LOCATION: AURORA, CO
WEB: VALVEXCHANGE.COM
Based in Aurora, Colorado ValveXchange
is developing a revolutionary two-part
bioprosthetic tissue heart valve system that
resolves the long standing compromises
between conventional mechanical and
tissue-based prosthetic valves. Unlike today’s
transcatheter valves, the ValveXchange system
is being designed to offer leaflet exchange,
as well as the original implant, without
open-heart surgery and without the safety
and longevity compromises of transcatheter
approaches. The ValveXchange procedure
can be done without open chest surgery or
cardiopulmonary bypass, the procedure can
be done transapically, through a small incision
between the ribs and a small hole in the apex
of the heart, both of which heal readily.
In 2009 CEO Larry Blankenship and
his team were incredibly efficient with
resources having designed and fabricated
an exchangeable valve prototype; tested its
performance in the sheep model; developed
an open-surgery exchange tool set; and,
demonstrated that heavy pannus overgrowth
can be managed with the ValveXchange
system. This rapid progress has not gone
unnoticed by the broader medical device
community, for the Company was awarded
the 2009 North American Frost & Sullivan
Technology Innovation of the Year Award
at their annual “Excellence in Medical
2010/2011
BIOSCIENCE COLORADO
Technologies & Life Sciences Awards”
banquet where other category company
winners included Covidien, GE Medical,
Philips Healthcare, Siemens Healthcare and
Intel.
COMPANY: PHARMJET
SECTOR: MED-DEVICE
CEO: HEATHER POTTERS
WEB: PHARMJET.COM
Based in Golden, Colorado, the PharmJet
needle free technology delivers pharmaceuticals
– vaccines and drugs –- through the skin via
a proprietary jet injection technology, no
needles – big or small, or patches of any kind
are used. The Company’s delivery device is
FDA cleared for marketing and can deliver
0.5ml of a liquid medication through the skin
of the arm, the abdomen, the thigh, into the
muscle or into the subcutaneous layer between
the skin and muscle. The PharmaJet needle
free device can be used to inject nearly any
licensed injectable liquid drug or vaccine. The
technology development does not end with the
0.5ml device, the pipeline is currently filled by
a 0.1 ml device for intradermal delivery into the
2mm upper layer of the skin where the immune
system is very active as well as a variable
volume device.
In 2009 CEO Rajen Dalal and his team
executed a collaboration with PATH (an
international non-profit organization that
creates sustainable, culturally relevant
solutions, enabling communities worldwide to
break longstanding cycles of poor health) to
evaluate needle-free injections for developingcountry immunization programs; regulatory
product clearance was received in Brazil by
the National Agency of Health Surveillance;
and, a variety of New Jersey counties and
townships incorporate the PharmJet device at
their seasonal flu vaccination clinics.
COMPANY: HEALTHAGEN
SECTOR: MED-IT
CEO: PETER HUDSON
WEB: HEALTHAGEN.COM
from Healthagen, is designed to aid the public
to evaluate their symptoms, list potential
diagnoses and provide access to appropriate
locations for treatment. The proprietary
healthcare search engine is designed to
provide for personalized point-of-care
healthcare decision-making.
The Company, led by CEO Peter Hudson
saw 2009 yield a number of important
technological and commercial milestones
including: the iTriage application becoming
available for the iPhone for free download
on the iTunes store, as well as becoming
available for all smart phones with a mobile
internet browser and connectivity including
BlackBerry, Android, Samsung, LG, Nokia,
Palm, T-Mobile, Sony and Motorola; a new
partnership with Centura Health, Colorado’s
largest healthcare provider, offering a
premier listing service for its healthcare
facilities in Colorado available on all of
its smart phone iTriage applications; in
addition to partnerships with Health Grades,
Teladoc, Coalition America and the National
Organization of Urgent Cares.
COMPANY: MD-IT
SECTOR: MED-IT
CEO: THOMAS CARSON
WEB: MD-IT.COM
Based in Boulder, Colorado, MD-IT was
originally founded as a technology company
with the goal of replacing traditional
medical transcription protocols. The
MD-IT product included front-end speech
recognition coupled with basic electronic
medical records before transcription and
document management services were
integrated into their platform. Today the
Company’s platform is a turn-key secure,
web-based transcription management system
that handles transport, workflow, delivery
and archival of medical transcriptions.
MD-IT is focused upon the flow of patient
information among physician offices,
transcriptionists, insurance companies, and
computer systems, all in an environment
that ensures security and privacy of patient
health information and achieving all HIPAA
compliance requirements.
CEO Thomas Carson and his talented team
at MD-IT concluded a very exciting year of
growth, some highlights included; opening
a new office in Seattle; three acquisitions
of existing transcription-oriented entities
in Texas, Michigan and Colorado; and,
announced that their charter membership
in a new industry consortium, the Medical
Transcription Service Consortium (MTSC),
formed to make it easier for physicians
and other authorized persons to exchange
electronic health information required for
patient care. The MTSC was established
by ICSA Labs, an independent division
of Verizon Business, and the Medical
Transcription Industry Association.
Move them.
In order to move your “prospects” to “customer” status, you have to
create awareness and demand. But how? By using an expert marketing
firm who consistently achieves this for medical technology companies.
Learn more: cbsa.ubiquitymedical.com
Say hello: [email protected]
Let’s talk: 303.962.8700
Follow us: twitter.com/ubiquity
Get connected: www.linkedin.com/in/gpolson
Based in Golden, Colorado, Healthagen
is a developer of healthcare information
software that empowers patients to make
better decisions and gives healthcare treatment
facilities improved access to additional
patients. iTriage, the first application available
BIOSCIENCE COLORADO
2010/2011 23
A Class Act
Today’s bioscience students prep
for tomorrow’s challenges
By Doug McPherson
W
hen little Kaitlyn
Mulhern was
6–years-old,
growing up in
Boise, Idaho, she got a
birthday gift that put her
career into sharp focus.
Yep, a microscope.
“I know it’s totally
cliché, but it’s true,” says
Mulhern, a Colorado
State University graduate
student in biochemistry.
“I was always collecting
random bug and plant
specimens to look at
under the microscope.”
Mulhern was hooked.
“Science is exciting,
fast paced and always
advancing,” she says.
“When you take a step
back and think about the
24
potential this research
has to save lives- it’s
incredibly gratifying and
motivating.”
And today she’s
getting hands-on
experience saving lives.
As part of her internship
at Inviragen, a biotech
company in Fort Collins
that develops several
vaccines, she’s working
Kaitlyn Mulhern
on a Dengue Fever
Vaccine. The Dengue
Fever is often spread by mosquitoes, and is viral and
often fatal. Mulhern explains she’s developing an assay to
molecularly characterize the final vaccine product. “It’s
an exciting time for Inviragen and I’m thrilled to be a
part of it,” she says.
As a sophomore, Mulhern interned at the California
biotech giant, Genentech, and worked in late-stage
purification and tested a high-pressure system used to
refold proteins and compare to the original protocol.
“I also got to see the entire process of getting a drug
to market … it was an
incredible experience.”
Another student,
Van Willis, is studying
molecular biology at the
University of Colorado
Denver Anschutz Medical
Campus. He, too, says
he’s in the field to make
peoples’ lives better.
“I want to apply my
scientific training to
help great ideas become
Van Willis
products and applications that improve lives.”
In one of his classes, Willis designed a complete
clinical trial from the ground up. “I learned how much
time and money clinical trials really take and the great
responsibility for patient safety; plus, how all the
research steps leading up to clinical trials are an integral
part of the clinical trial itself, and why you need an
excellent plan in the pre-clinical phase.”
Willis also presides over the Alternatives in Science
Club (AIS), a student-run group that focuses on career
development in science outside of academia (more on
AIS and career development in a minute). He says his
work there has helped him appreciate the regulations
of research and manufacturing. “It’s given me the big
picture of why the regulations are in place and the
purposes behind why the bioscience industry operates as
it does.”
And then there’s Misty Rowe-Konopacki, a postdoctoral fellow in applied chemistry at Mines, whose
studies led to her co-founding TheragNos, an early stage
biotech company in
Golden. The company
works to dramatically
improve the therapeutic
outcome of both the
imaging and treatment
of many diseases. Today
Rowe juggles both the
business and research
sides of biotech: writing
proposals, getting
investors and working in
the lab.
Misty Rowe-Konopacki
Rowe-Konopacki
was originally a pre-med
undergrad but in her senior year she got the chance
to develop potential breast cancer drugs as a research
2010/2011
BIOSCIENCE COLORADO
PHOTO BY TINA WOOD
status but lack funds. They’re looking at
sources for cash including grants and industry
sponsorships. “We have to make sure the
funding is sustainable,” Meyers says.
If it does happen, Willis says the
program would feature specialized courses
in bioscience along with patents, regulatory
affairs, business among others, and plenty of
interaction between students and bioscience
industry leaders via internships and guest
speakers.
In the meantime, Willis says AIS is
connecting local bioscience companies
and industry pros with students through
monthly question-and-answer sessions and
“matchmaker” meetings where employers
introduce their companies and employment
to students. To learn more, visit www.
aiscolorado.org.
For the longer-term future, Meyers says he
believes there are three keys to adding more
scientists from schools to the job pools: “We
know you need math before you can learn
science; we need to reach students before and
during middle school and we have to have
parental involvement.”
Despite any labor force shortfalls, Willis
is bullish on Colorado’s future: “Colorado
bioscience is poised to continue growing.
Whether it will do so with an influx of
Colorado’s best students hinges on the ability
of Colorado’s bioscience sector to connect
with local universities to share essential
information and training.”
Willis can count on Mulhern. She says
after grad school, her aim is a doctorate in
biochemistry or molecular biology. “After that,
I’d love to come back to Colorado and work
at a biotech company. Colorado has so many
start-up companies … that have huge potential
to do great things for people. I know this is the
right place for me.”
project. “That sent me down the bioscience
research road,” she says. “I’d learned that
while physicians implement the cures, the true
innovation comes from those who are doing
the base level research.”
FROM SCHOOL TO JOB POOL
All three are first-class examples of
the faces in the future of bioscience. Faces
Arlen Meyers, M.D., would like to clone to
keep students streaming out of colleges with
degrees in the sciences to fill Colorado’s need
for employees.
“Clearly, there’s a demonstrated need in
Colorado and elsewhere for bioscience talent,”
BIOSCIENCE COLORADO
2010/2011 says Meyers, a professor of otolaryngology
at CU-Denver and an activist in growing
Colorado’s scientific workforce. “A lot of
scientists are going for academic jobs, but
there aren’t any.
That leaves students who’ve studied
biosciences, but who lack the skills they
need to work in the industry outside of the
classroom. Willis says Colorado students
“face a difficult transition” from academia to
bioscience.
One way Meyers hopes to solve the
problem is through a kind of biotech/
entrepreneurship and internship program.
He and Willis have the program near liftoff
Arlen Meyers
25
On The Verge Of Greatness:
Colorado Grants Develop
Innovative
Research
HB 1001 PROOF-OF-CONCEPT GRANTS
COLORADO SCHOOL OF MINES
INVESTIGATOR: Brajendra Mishra, PhD
TITLE: Biocompatibility study of oxide-coated titanium alloys for
dental implants
RESEARCH: This grant supports research to better understand the
osteo-integration of titanium and its alloys, specifically in the oral
cavity for the commercial potential of oral prostheses.
IMPACT: If successful, this project will point to some alloys that can
be used to improve upon the stability, longevity and strength of
dental implants.
T
he Bioscience Discovery Evaluation Grant Program (BDEGP)
began in 2006, when the state began to realize the importance of
supporting the thriving bioscience industry. The support came into
effect through a matching grant program that offered support to
researchers trying to establish proof of concept.
Success shown by the state’s initial funding allowed Colorado’s
legislature to expanded the program in 2008, creating a five year and
26.5 million dollar matching grant program. The BDEGP now helps
the industry by providing matching grants in three key areas: proof of
concept for Colorado’s research institutions, early-stage companies, and
to build infrastructure for the growing industry.
As we embark on the fourth year of the Bioscience Discovery Evaluation Grant Program (BDEGP), we realize that the research and innovations being conducted by Colorado’s bioscience community will never
cease. The following tables showcase the research and companies that
have been awarded grants from the fourth quarter of 2008 until now.
26
INVESTIGATOR: Keith Neeves, PhD.
TITLE: Microfluidic flow assay for diagnosing bleeding and throm-
botic disorders
RESEARCH: The strategic objective of this project is to validate
a microfluidic-based flow assay that can diagnose bleeding and
thrombotic disorders and eventually predict risk for bleeding.
There are currently no methods that can accurately predict bleeding
disorders.
IMPACT: Would be the first blood test to take place as the blood is
flowing and could screen for multiple conditions. If successful it
could replace and/or complement traditional hematological assays.
2010/2011
BIOSCIENCE COLORADO
NATIONAL JEWISH HEALTH
Investigator: Carl W. White, MD.
Title: Thioredoxin as mucolytic agent for cystic fibrosis.
Investigator: David Lynch, MB and Russell Bowler, MD, PhD.
Research: The goal of this grant is to identify a novel thioredoxin
Title: Textural approach to quantification of diffuse lung disease on CT
Research: Under this grant, a new commercially viable, clinically
valid, set of texture-based tools for CT image analysis of chronic
obstructive pulmonary disease and idiopathic pulmonary fibrosis
will be developed with the aim of quantifying diffuse lung disease.
Quantification will allow for appropriate novel treatment.
that disrupts cystic fibrosis sputum without causing or enhancing
inflammation in cystic fibrosis lung disease or disease models.
Impact: Cystic fibrosis (CF) is the most common fatal genetic disease among Caucasians. The main cause of death in the disease is
chronic lung infection, caused by the inability to clear thick sputum
from the airways. This discovery will utilize a naturally occurring
agent, thioredoxin, which can break down the sputum.
Impact: CT scans are commonly performed, yet the information
and abnormalities are described in only vague terms. This project
will provide a novel approach to the challenge of identifying features of lung disease on CT, allowing for a more precise description
of any abnormalities found in a scan.
COLORADO STATE UNIVERSITY
Investigator: Nora Lapitan, PhD and B Joe E. Brummer, PhD
Investigator: Laurel L. Lenz, PhD.
Title: Evaluation of Miscanthus as a Bioenergy Crop in Colorado
and Development of Genetic Resource
Title: Therapeutic activation of Natural Killer cells for treatment of
haematological cancers
Research: The aim of this work is to develop E415 and “second
generation” derivatives of E415 as potential commercial Natural
Killer cell activating therapeutics.
Impact: Developing a novel therapeutic that would activate NK
cells which would target and kill certain haematological cancer
cells.
Research: The goal of this project is to evaluate Miscanthus and
M. sinensis for agronomic performance in Colorado and develop
genetic resources fo M. sinensis to facilitate breeding and cloning
of genes for biomass and other traits including adaptability and
drought tolerance. The long-term objective is to develop Miscanthus cultivars adapted to Colorado and the western U.S. as a biomass
resource for fuel.
Impact: Not only is Miscanthus a viable crop for bioenergy, adapt-
ing the grass to grow prolifically in land unable to support other
crops leads to additional crop sources and income for farmers.
Investigator: Vijaya Nagabhushanam, PhD and Ronald J. Har-
beck, PhD
Investigator: Patrick F. Byrne, PhD and Shusong Zheng, PhD.
Title: Immortalization of basophils towards the development of the
next generation assay for the laboratory diagnosis of autoimmune
chronic urticaria
Title: Overcoming the Bottleneck of Oilseed Crop Development for
Research: The aim of this work is to develop an immortalized
Research: The goal of this project is to identify key traits – dwarf
basophil-like cell line that will replace the need for individual human donor basophils for the evaluation of anti-Fc epsilon R1alpha
antibodies that assist in the laboratory diagnosis of autoimmune
chronic urticaria.
stature, improved stem strength, and altered oil profiles – in Brassica juncea. This plant is targeted as an oilseed biofuel crop suitable
for Colorado.
Biofuels through Mutagenesis and Interspecies Crosses.
Impact: Stable and reliable crop suitable for biodiesel production in
Impact: Developing a diagnostic assay for chronic urticaria. This
Colorado.
disorder is defined as the presence of hives lasting for at least
six weeks. Autoimmune uticaria is triggered by auto antibodies
to the high affinity immunoglobulin E (IgE) receptor, FcεR1α,
present in serum of affected individuals. These antibodies bind
to FcεR1αon basophils and trigger degranulation and thereby
symptoms.
BIOSCIENCE COLORADO
2010/2011 27
Investigator: George Collins, PhD
Investigator: Matt J. Kipper, PhD
Title: Water Plasma for Tooth Surface Texturing, Functionalization
Title: Development of Nanoparticle Optical Trap-Base Biosensor
and Biofilm Removal
Research: Build a prototype optical trap‐based biosensor, evaluate
Research: This work advances a room temperature water-plasma
device to generate chemically active species for tooth surface
texturizing and functionalization. The technology avoids generating
hazardous components to surrounding tissues. The grant work will
focus on the selective removal of layers deposited on teeth including proteins and biofilms associated with periodontal disease.
its performance by measuring limits of detection for bacteriophage
(or a another suitable target analyte), and design experiments to test
a mathematical model describing the optical trapping phenomenon.
The goal is to develop a more rapid and sensitive technique for
detecting food-borne and water-borne pathogens.
Impact: Better and more rapid detection of pathogens means a safer
Impact: Replacement of current technology which utilizes toxic and
food supply.
carcinogenic materials.
Investigator: Kenneth F. Reardon, PhD
Investigator: Jessica G. Davis, PhD
Title: Multichannel Optical Biosensor for Detection of ContamiTitle: Harnessing the Sun for On-farm Fertilizer Production
nants in Water and Food
Research: Grantee will develop a low-cost bio-fertilizer production
Research: This project advances the technological state of an opti-
system that will reduce fossil fuel use and greenhouse gas emissions from fertilizer production and transportation. Bio-fertilizer
technology is an untapped solution to food security, energy, and soil
fertility issues worldwide. Using technology developed through this
research, farmers will be able to use bacterial nitrogen (N) fixation
to harness the sun’s energy and create fertilizer from the air we
breathe.
cal enzymatic biosensor platform by using biological and engineering approaches to increase the biosensor lifetime, improving the
multichannel optoelectronic hardware system used for measuring
analytes in mixtures, and developing multichannel calibration and
measurement protocols. The multichannel optical biosensor will be
used to detect contaminants in water and food.
Impact: The ability to easily and accurately monitor water and food
Impact: Bio-fertilizers will contribute to the sustainability and
competitiveness of small to mid-sized farms by decreasing costs
and energy needs.
supplies for contaminants has tremendous health and economic
benefits.
Investigator: Melissa Reynolds, PhD
Investigator: Lawrence D. Goodridge, PhD
Title: Universal Biocompatible Coating Process for Medical DeTitle: A Multiangle Light Scattering Biosensor for Rapid Detection
vices
of Waterborne Viruses
Research: This project is focused on investigating the viability of
Research: The objective of this proposal is the development of a
Multiangle Light Scattering Biosensor for Rapid Detection of Waterborne Viruses. In this method, viruses in large (10-50 L) volumes
of water are concentrated using anionic exchange resin beads. The
beads (with viruses attached) are added to a tissue culture flask,
which contains a suitable cell line. The viruses will infect the cells,
and after an incubation period of several hours, an aliquot of the
infected cells is analyzed for viral infection using multiangle light
scattering, which is a technique capable of detecting changes in
virus infected cells relative to non infected cells (control). The
method is simple to complete and is expected to lead to much faster
detection times than currently used methods.
novel metal-organic frameworks (MOF) as delivery materials for
use in biomedical coatings.
Impact: The coatings will mimic the function of healthy living cells
and be a more natural and safe approach to healing.
Impact: Rapid and accurate detection of pathogenic viruses has
worldwide implications for safety of water and food supplies.
28
2010/2011
BIOSCIENCE COLORADO
Investigator: Ronald B. Tjalkens, PhD
Title: Development of Neuroprotective Compounds for Treating
Parkinson’s Disease
Research: The neurological symptoms of Parkinson’s disease (PD)
are caused by the degeneration of neurons in the midbrain but there
are no approved drugs that slow this process, only those that treat
the symptoms caused by neuronal loss. The objective of this project
is to characterize the efficacy and safety of a novel series of antiinflammatory compounds to test their suitability as a new treatment
for blocking the progression of PD.
Impact: Successful application of these compounds will block the
neuroinflammation caused by PD in order to halt the disease rather
than just controlling the symptoms.
Investigator: Kristi Anseth, PhD
Investigator: John D. Williams, PhD and Ketul Popat, PhD
Title: Acute full-thickness wound healing; custom therapeutics,
bio-responsive thiol-enes.
Title: Evaluation of Hydroxyapatite Coatings Deposited Using
Novel Plasma Based Deposition Techniques for near Term Implementation in Dental and Orthopedic Implants
Research: Develop optimized coatings that are needed to improve
the longevity and effectiveness of load-bearing hip arthroplasty
components. Project work involves characterizing plasma based
ion implantation and deposition (PBII&D) and plasma enhanced
chemical vapor deposition (PECVD) as novel techniques for applying thin film hydroxyapatite (HA) coatings onto titanium, titanium
alloy, and next-generation titanium -alloy implantable biocompatible materials.
Research: The strategic objective of this project is to complete a
pre-clinical efficacy study of the performance of a novel biomaterial system in promoting wound healing in a human equivalent
large animal model. Bioresponsive thiol-ene hydrogels are designed
to increase the efficiency of wound closure and reduce scaring.
Impact: More effective treatment for severe wounds such as dia-
betic ulcers.
Investigator: Stephanie J. Bryant, PhD.
Impact: Creation of better coating techniques so as to avoid revi-
Title: Mechanically trained engineered cartilage for craniofacial
sion surgery due to loosening or infection within the patient’s
lifetime.
reconstruction.
Research: The goal of the project work is to create new therapies
for treating patients who are in need of craniofacial reconstruction.
COLORADO INSTITUTE OF MOLECULAR BIOTECHNOLOGY
Impact: Cartilage for craniofacial reconstruction that can be formed
from a patient’s own cells rather than artificial materials.
Investigator: Natalie Ahn, PhD
Title: Pharmacophore Optimization for Targeted Therapeutics
Investigator: Xuedong Liu, PhD.
Research: The goal of this project is to develop a medicinal
Title: Targeting mitotic kinase Mps1 for cancer therapy
chemistry core resource whereby identified lead compounds will be
optimized, using the expertise of medicinal chemistry in an iterative
processes, for the treatment of chronic pain and cancer.
Research: Develop patentable potent sub-nanomolar small mol-
Impact: Develop new composition of matter intellectual property
ecule compounds against TTK/Mps1 and test the efficacy of these
inhibitors in human cancer cell lines and xenograft models. The
outcome will improve the results of oncology drugs.
for therapeutic drug candidates associated with proprietary drug
screen assays at CU.
Impact: Current anti-mitotic cancer therapies have severe side ef-
fects on healthy, non-cancerous cells. This project seeks to further
develop novel drugs for the treatment of cancer, with a primary
focus on lung cancer.
BIOSCIENCE COLORADO
2010/2011 29
UNIVERSITY OF COLORADO
Investigator: Sean Colgan, PhD.
Title: IBD-DIFF: Commercial Development of a CD116-based
assay to distinguish irritable bowel syndrome from inflammatory
bowel disease.
Research: Development, validation, and commercialization of
a diagnostic blood test named “IBDiff ”, to distinguish between
inflammatory bowel disease and irritable bowel syndrome. IBDiff
relies on identifying the GM-CSF receptor, CD116, on circulating
leukocytes as a specific biomarker in distinguishing IBS from IBD.
Symptoms of IBS and IBD are similar while treatment is quite different, the ability to easily distinguish the two conditions improves
treatment and reduces costs associated with testing for IBD.
Impact: Will allow lower cost and more presice diagnosis with ear-
lier and more efficacious treatment of both IBD and IBS patients.
Investigator: Jeff Olson, MD.
Title: Zip Clip – Microsurgical suturing device.
Research: The goal of this project is to position the “Zip Clip” for
first-in-human use. The “Zip Clip” is a surgical system consisting
of a minimally invasive dep0loyment tool designed to accurately
and safely deliver a nitinol clip to suture in the setting of complex
ophthalmic microsurgical procedures, wherein conventional suturing is either impractical or critically time-intensive.
Title: DT-EGF for the treatment of bladder cancer.
“510(k)” refers to Section 510(k) of the Food, Drug and Cosmetic
Act which requires device manufacturers to notify the Food and
Drug Administration of their intent to market a medical device.
Research: The goal of the project is to advance the clinical
Impact: Lower the cost, time, and improve outcomes in opthamo-
development of DAB389EGF for the treatment of bladder cancer.
DAB389EGF is being explored as a targeted toxin that will bind to
tumor cells and kill the targeted cell. Additional pre-clinical data
will be developed to support a pre-IND meeting.
logic surgery.
Investigator: David Ross, PhD.
Impact: Add an alternative therapy to the 50% of bladder cancer
Title: Novel benzoquinone ansamycins. Hsp90 inhibitors with
patients that are not benefited by standard of care.
decreased toxicity
Investigator: Thomas Flaig, MD.
Research: The goal of this project is to limit toxicity of an anticanInvestigator: Ryan T. Gill, PhD.
Title: Molecular biorefining for sustainable gasoline.
Research: The goal of this project is to demonstrate a new pathway for
the sustainable production of fungible gasoline from cellulosic biomass.
cer agent (Hsp90 inhibitors).Hsp90 inhibitors allow a combinatorial
inhibition of multiple pathways that drive the oncogenic process
and are an attractive anticancer targeting strategy; however, the
Hsp90 inhibitors being developed are benzoquinone ansamycins
which have a dose limiting toxicity. Under the project, 19-substituted benzoquinone ansamycins will be evaluated for effectiveness
and decreased toxicity.
Impact: Potential for cost-competitive production of gasoline from
biomass rather than fossil fuel sources.
Impact: A more effective cancer drug with fewer toxic side effects.
Investigator: Malik Kahook, MD.
Investigator: David H. Wagner, PhD.
Title: KSCO: Keep Schlemm’s Canal Open
Title: A novel small therapeutic peptide prevents and reverses
autoimmune diseases
Research: The primary goal of the work is to design, develop and test a
novel shape memory polymer based device for maintaining fluid communication between the anterior chamber and collection channels of
the eye. Such a device would improve outcomes for glaucoma patients.
Research: The project goal is to identify lead candidate peptides
proving efficacious treatment options in delaying/preventing/reversing diabetes.
Impact: Allow for more sustainable, lower cost treatment of the
Impact: Slowing or halting the progression of autoimmune disease
symptoms associated with glaucoma.
before permanent organ or joint damage occurs.
30
2010/2011
BIOSCIENCE COLORADO
UNIVERSITY OF DENVER
Investigator: Rahmat Shoreshi, PhD.
Title: Adaptive cast for enhanced healing and reduced cost.
Research: Under this grant, a semi-permanent, reusable cast for
diabetic patients suffering from peripheral neuropathic foot ulcers
will be developed. It is intended to be a safer, more effective means
of healing foot injuries while reducing costs.
Impact: This Adaptive Cast has the potential to have healing effi-
ciency while also providing features that include forced compliance
(semi-permanent design), early detection of new ulcers and immediate pressure reduction in new ulcer area, active control system for
off-loading, skin toughening subsystem to reduce immediate onset
of new ulcers after removal of the cast, simpler application and no
requirement for specialized technicians.
EARLY STAGE COMPANY AWARDS – 2009 TO PRESENT
InDevR, Inc. Boulder
This grant supports the commercialization of a new detection
technology (Phox™) for low-density microarrays that enables
inexpensive and rapid identification of pathogens in a robust and
field portable diagnostic platform. The products, specifically the
Phox™ reagent kits and associated equipment (e.g., the IntelliChip
Reader™), will be launched for food safety testing or the identification of viruses that cause respiratory diseases.
KromaTiD, Inc., Fort Collins
KromaTiD is working to create the next generation of chromosome
analysis products, which will have valuable application in clinical diagnostics, biomedical research, and biodosimetry. This grant
supports the evaluation of the technology’s market opportunity in a
formal business plan.
MicroPhage, Inc., Longmont
The main objective of the project is to increase the sensitivity of
phage amplification technology via optimization of amplification
(AMP) reagents and sample processing to meet the increased performance demands of the nasal swab sample for MRSA screening.
Oberon FMR, Inc., Idaho Springs
Develop, validate and commercialize “QuantumCharge”, 2C Tech’s
proprietary intraocular implant as a next-generation, in vivo system
for stimulating degenerated retinal cells and restoring vision.
The main objective of the project is to improve Oberon’s process
for converting food-processing byproducts into Single Cell Protein
for animal feeds by increasing protein content and reducing protein
content variability.
BioAMPS International, LLC, Aurora
PolyNew Inc., Aurora
This grant builds on a prior grant under the BDEGP to identify
a drug solution or solutions to the problem of gram-positive and
gram-negative bacteria resistance to conventional antibiotics
through the introduction of an antimicrobial technology with no
known route of drug resistance.
The grantee is developing next-generation bioplastics for food and
beverage containers, and must test the technology for large industrial application.
2C Tech Corporation, Longmont
ClariMedix Inc., Boulder
The goal of this grant is to further the development of a proprietary
medical device technology with the ability to non-invasively trigger
and modulate the production of nitric oxide to treat Alzheimer’s
disease.
Flashback Technologies, LLC, Longmont
The goal of this grant is to develop an improved prototype device,
building on prior work, for estimating a patient’s blood volume
loss and the conditions for cardiovascular collapse. This will offer
a non-invasive device to provide a real time estimate of a patient’s
volume of blood loss, and a real time estimate of when a patient
will experience cardiovascual collapse so that medical personnel
can quickly and accurately identify and manage bleeding patients.
Quest Product Development Corp., Wheat Ridge
With grant funds the company will establish a dedicated thin-film
actuator fabrication line. Quest is developing MicroFlex Technology for digitally controlling the shape of an endoscope by using
advanced shape memory alloy micro-actuators fabricated as thin
film assemblies using integrated circuit manufacturing techniques.
MicroFlex technology will allow endoscopes that are far more
flexible, thinner and guidable, enabling access, visualization and
treatment at currently inaccessible locations.
Snoasis Medical, Inc., Denver
Evaluate two different Human Platelet Morphogen (HPM) processing methods and specify top line requirements for a pilot manufacturing facility. Research developed will support an NIH Phase
II grant application. HPM holds great potential for use in dental
surgery to speed healing and improve outcomes.
HepQuant LLC, Aurora
ValveXchange, Inc., Aurora
This grant builds on a prior grant under the BDEGP to further
the development of a diagnostic test for hepatic portal circulation
which will enhance the safety and accuracy of assessing liver function. Under this grant HepQuant will initiate FDA clinical trials of
“HepQuant-Dual”.
The grantee is developing a novel implantable heart valve technology allowing for minimally invasive surgery for the replacement of
leaflet sets. This combined with patient specific heart models will
allow for an optimal valve exchange procedure.
BIOSCIENCE COLORADO
2010/2011 31
INFRASTRUCTURE AWARDS
Colorado Institute for Drug, Device and Diagnostic
Development
The Colorado Institute for Drug, Device and Diagnostic Development will manage life science discoveries from Colorado research
institutions and start-up companies through feasibility, pre IND
studies, and initial clinical trials with the goal of creating viable
new Colorado bioscience companies supporting quality jobs.
CSU – Colorado Center for Drug Discovery
The Colorado Center for Drug Discovery (C2D2) fills a gap in
drug-discovery at CO research universities. The C2D2 provides
medicinal chemistry, pharmacokinetics, and consulting resources
to create new patent-protected compounds useful for validation of
novel drug discovery targets and drug candidates for clinical development by Colorado biopharma companies and others.
This grant supports the C2D2 as a resource to faculty at Colorado
research universities, bringing biology and chemistry faculty together to use chemical libraries, computational resources, bioinformatics, cheminformatics, database support, virtual high throughput
screening, and Computer Aided Drug Design to pharmacologically
validate drug candidates with patent-protected chemical matter and
innovative therapeutics for unmet medical needs.
Furthermore, the infrastructure and framework of expertise created by C2D2 across Colorado research universities will expand
opportunities for emerging Colorado bioscience companies to
access critical expertise and resources that would be difficult to
establish within these companies.
CU – Colorado Initiative in Molecular Biotechnology
This grant supports the development of a state-of-the art research and
education facility that links the basic sciences, engineering, clinical
practice, and industry at the University of Colorado’s Boulder campus
to support breakthrough developments in areas such as engineering
human tissues, RNA enzyme and aptamer based pharmaceutical,
biorefining, and genetics. Grant funds will applied to equipment,
resources and personnel costs of the Integrated Novel Therapeutic
Discovery Center , and to support architectural, engineering, and construction services (as per policy of the State of Colorado’s Office of the
State Architect), and equipment costs of the Vivarium Expansion.
CU – Drug Development Center High Throughput
Screening Core
Pharmaceutical Research & Manufacturers of America
Disease is our enemy. Working to save lives is our job.
32
This grant supports the establishment of a Core Facility for high
throughput screening of small molecule libraries against molecular
targets, open to users within Colorado.. A gap in capability for
many current researchers in Colorado is the inability to perform
HTS screens against a particular molecular target to identify hit
molecules. Hit molecules can be developed into lead molecules
which often form the basis for intellectual property, subsequent
company formation and economic development.
2010/2011
BIOSCIENCE COLORADO
DEPARTMENT HEAD
What Colorado Can Do For You:
Colorado’s Investments
In the Biosciences
By: Leah Kientz
BY
A
bioscience cluster
with world-renowned resources
and talents sits at
the base of the Rocky
Mountains. Colorado’s
growing bioscience
industry proves that this
skier’s paradise has not
only beautiful scenery but
also internationally competitive research facilities,
investors and bioscience
firms.
While many states are
itching to grow their own
bioscience cluster, the
Colorado state government has been nurturing
this sector for more than
20 years. As a result, there
are a variety of state-led
business incentives and
investment funds for
bioscience firms. These
incentives help Colorado’s
research institutions spin
out a handful of new
companies a year and bring more business to the Rocky
Mountain Region.
Here is a look into some of these programs;
The Bioscience Discovery Evaluation Grant Program
The Bioscience Discovery Evaluation Grant Program (BDEGP), originally funded in 2006 for $4.5
million, received another $26.5 million in 2008 which
will be funded over a five year period. The funds will
be disbursed through the Colorado Office of Economic
Development and International Trade (OEDIT).
BIOSCIENCE COLORADO
2010/2011 The BDEGP provides 30 percent of the funds for
“proof of concept” matching grants through the OEDIT
to Colorado technology transfer offices to accelerate
commercialization of bioscience technologies up to
$150,000 per research project. Evidence of a dedicated,
matching source of monies that is equal to the amount
applied for under the program is required and cannot be
used to supplement the funding of research scope of the
project.
Another 30 percent of the funds are provided as
matching grants to early stage Colorado-based bioscience
33
companies that have licensed a technology
from a state research institution. These state
matching funds will be given to companies
that have received less than $5 million dollars
from grants and third-party investors and that
employ fewer than 20. The grants shall be for
no more than $250,000 over the lifetime of the
company. Evidence of a dedicated matching
source of monies that is equal to the amount
applied for under the program is required.
Lastly, up to 40 percent is dedicated to support partnership efforts between the bioscience
industry and research institutions to build
infrastructure that supports the commercialization of therapeutic and diagnostic products,
devices or instruments to improve human
health, agriculture and biofuels.
For more information on the Bioscience Discovery Evaluation Grant Program or to apply,
please visit www.AdvanceColorado.com.
The Colorado Innovation Investment Tax
Credit (CIITC)
CIITC was created in 2009 by the Colorado
legislature (House Bill 09-1105) to encourage,
Top-Quality Life Science, Priceless Networking
Keystone Symposia on Molecular and Cellular Biology, a nonprofit
organization based in Silverthorne, Colorado, has been conducting
open, international conferences for research scientists since 1972.
Listen to presentations on unpublished data, gain feedback on your
research and build new collaborations at any of 55 conferences to
be held fall 2010–spring 2011 all over the world. Meetings include:
• Immunological Mechanisms of Vaccination,
October 27–November 1, 2010, Seattle, Washington, USA
• Antibodies as Drugs, February 6–11, 2011, Keystone, Colorado, USA
• Biofuels, March 1–6, 2011, Singapore
• Stem Cells, Cancer and Metastasis, March 6-11, Keystone, CO
• Evolving Approaches to Early-Stage Drug Discovery,
April 3–7, 2011, Snowbird, Utah, USA
Rates are the same for industry as academia. Visit us on the web at
keystonesymposia.org/2011meetings and at BIO (booth #1426).
34
promote, and stimulate investments in new,
small Colorado businesses primarily involved
in research & development, or manufacturing,
of new technologies, products, or processes. CIITC is a one year pilot program that
provides investors a state income tax credit of
15% (not to exceed $20,000) of the amount
invested during calendar year 2010. The
program’s primary goal is to motivate angel
investors to provide capital to early-stage companies. Successful, newly funded, companies
then become growth engines for the state, and
help attract additional investors and entrepreneurs.
For more information on the Colorado
Innovation Investment Tax Credit or to apply,
The Job Creation Performance Incentive
Fund
Companies that maintain new positions
with salaries at least 110 percent above the
average salaries in their counties for one year
will be awarded with a performance-based
incentive. Three million dollars will be distributed annually by The Economic Development
Commission (EDC) with administrative support from the Office of Economic Development and International Trade. The goal of this
program is to foster new business development, business expansion and relocations that
generate new jobs within the state.
Companies located in rural areas must
hire at least five new full-time employees
in six months and companies in urban areas
2010/2011
BIOSCIENCE COLORADO
must hire 10 new full-time employees in six
months. Businesses with multiple locations in
Colorado may combine locations to meet the
minimum requirements. Contact Colorado’s
Office of Economic Development and International Trade at www.advancecolorado.com
CRB is a global provider of end-to-end solutions for life science and advanced technology companies. Our solutions deliver enhanced value, productivity and return on
investment. Whether you are across town or across the pond, CRB’s consulting, design and construction expertise will meet your R&D and manufacturing needs, while
adding some black to your bottom line.
www.crbusa.com
Job Growth Incentive Tax Credit
The Job Growth Incentive Tax Credit
provides a state income tax credit to businesses
undertaking job creation projects that would
not occur in Colorado without this program and
that have met certain requirements under the
Economic Development Commission’s (EDC)
Job Growth Incentive Tax Credit Program.
Businesses have to create at least 20 net
new jobs in Colorado during the allocated
credit period with an average yearly wage of
at least 110% of the county average wage. A
business located in an Enhanced Rural Enterprise Zone has to create at least 5 net new jobs
in Colorado during the allocated credit period
with an average yearly wage of at least 110%
of the county average wage.
For more information on the Colorado
Innovation Investment Tax Credit or to apply,
Jason Robertson
816.891.3667
[email protected]
www.crbusa.com
Consulting
Design
Construction
Commissioning
Qualification
Biotechnology R&D Sales and Use Tax
Refund
Colorado’s biotechnology industry has the
ability to recover the sales and use taxes paid
in the preceding year on equipment and supplies purchased to conduct biotechnology research and development. The biotech company
may seek a refund every year for all Colorado
sales and use taxes they paid on purchases of
tangible personal property used directly in
research and development of biotechnology.
Qualified applicants must submit a refund
claim between January 1 and April 1 to the
Colorado Department of Revenue. The refund
helps promote the biotechnology industry in
the state, aiding both start-up and established
companies.
During the 2009 legislative session, the
Colorado state legislature voted to expand the
Biotechnology R&D Sales and Use Tax Refund to include both medical device and clean
technology companies. While this legislation
passed, the expansion will not take effect until
the Legislative Council of the state indicates
that general fund revenues are sufficient
enough to maintain the program.
To find out more information or to submit a
refund claim, contact the Colorado Department
of Revenue or visit www.revenue.state.co.us.
BIOSCIENCE COLORADO
2010/2011 -Custom exhibits
-International and
domestic rentals
-Modular and
portable exhibits
-Installation and
logistical services
-Graphic design
and in-house
production
for more information
please call
Ned Mackey
303 698 3971
www.condit.com
35
minimum specified requirements. Investments
range from $250,000 to $3.375 million.
For more information or to submit a funding request, please visit www.Coloradofund1.
com.
Manufacturing Equipment Exemption from
Colorado Sales and Use Tax
The purchase of machinery or machine
tools and parts are exempt from state sales and
use tax when the machinery will be used in
manufacturing. The machinery must be used
to manufacture tangible personal property for
sale or profit in Colorado. The tax exemption includes tangible personal property that
will be used for one year or more and limits
qualifying purchases of used equipment to a
maximum of $150,000 annually.
For more information, contact the Colorado
Department of Revenue at www.revenue.state.
co.us.
Enterprise Zone
Certified Capital Companies (CAPCOs)
The Certified Capital Companies Program
was created by the Colorado legislature with
the goal of making venture capital funds
available to new or expanding Colorado small
businesses. The CAPCO Program is expected
to create new employment opportunities
within the state and to stimulate economic
growth. Colorado has six independently operated CAPCOs that provide loans and equity to
Colorado businesses. Investments generated
from a CACPO generally range from $100,000
to $3.3 million.
To receive funding you must contact the
CAPCOs directly. To view a list of CACPOs
please visit http://www.state.co.us/oed/business-finance/capco-list.cfm.
Venture Capital Authority
The Colorado General Assembly in 2004
passed legislation that established the Colorado Venture Capital Authority (VCA), and in
2005 High County Venture was selected as the
fund manager to establish the first fund. Colorado Fund 1 will make seed- and early-stage
capital investments in businesses. The VCA
anticipates the establishment of a second fund
of approximately $25 million in 2010.
High Country Venture is independently operated and generally makes independent funding
decisions. State approval is limited to ensuring that businesses receiving funding meet
Colorado’s enterprise zone program provides tax incentives to encourage businesses to
locate and expand in economically distressed
areas. Criteria for the establishment of zones
include higher-than-average unemployment
rates, low per capita incomes, and/or a population base of less than 80,000. There are 18
enterprise zones and subzones in Colorado. Businesses making qualifying investments
and creating jobs in these zones are entitled
to various incentives, including ten different
enterprise zone tax credits.
To view the enterprise zones or for more information on tax incentives, please visit www.
AdvanceColorado.com.
Job Training Grant Funds
The Colorado First and Existing Industry grants are jointly administered by the
OEDIT and the Colorado Community College
System. Colorado First grants are provided to
companies relocating to Colorado or existing
companies undertaking a major expansion.
The Existing Industry grants are designed
for Colorado companies implementing new
technology in order to remain competitive and
retain local jobs.
Both grants assist with the cost of employee
training. The grant-funded training must be
for permanent full-time positions that require
substantive and company specific training.
Training must occur within the fiscal year that
funds are awarded, and the company must pay
a minimum of 40 percent of the total cost of
training. The grant applications are reviewed
on a rolling basis throughout each fiscal year,
and the grants generally fund up to $800 per
employee.
To apply for the grants or for more information, please visit www.AdvanceColorado.com
Local Incentives
Your local community may also provide
business development incentives. For additional information, contact your local economic
development organization. A list can be found
at www.advancecolorado.com.
Go to www.coloradoprospects.com to find
more information on Colorado’s business
incentives.
36
2010/2011
BIOSCIENCE COLORADO
As the premier provider
of non personal marketing solutions for the pharmaceutical, health care and life science industries, PROMOTECH provides a
comprehensive suite of services customized to meet your portfolio objectives. As a “one stop shop” our services can stand alone
or can be bundled, creating an all-inclusive package.
Warehouse and Fulfillment Services
Database Management
With almost 400,000 square feet, PROMOTECH fulfillment.
Database management is key to ensuring you reach the right
PDMA, GMP compliant, VAWD accredited and FDA and DEA
person, with the right message. PROMOTECH’s sophisticated
registered, we are licensed to Schedule II. Expertly integrated with
system extracts and manages the data that guides your marketing
Manhattan Associates Warehouse Management system, our strict
decisions. No guessing, no games. Just the information you need
quality control ensures accurate pick and pack of materials.
to target the right market. Our services include list acquisition and
qualification, data mining, expert analysis and custom
TeleSolutions
PROMOTECH’s robust Cisco Phone Switch, a 60+ seat Call Center,
report generation.
our dedicated team of professionals. Everything you need to
Printing and Direct Mail Services
communicate your message effectively, quickly and professionally.
Our Print Center is comprised of the finest printing technology
PROMOTECH’s TeleSolutions are the key in reaching your target
available with the industry experience to match. We can print an
market. Enhance your current field force or penetrate vacant
array of marketing pieces including: visual aids, brochures, PI’s,
territories through comprehensive tele-detailing and sampling
Slim Jims, and welcome kits and feature additional services such
services.
as bindery, ink jetting, insertion and more.
eSolutions
Effective direct mail can improve your campaigns significantly.
Our Internet services provides the recognition your business needs.
Our team will consult with you to ensure your pieces are opened,
From enhancing your current platform to ecommerce or complete
read and get a response.
portal development, PROMOTECH’s experienced team of IT
professionals, have the tools to create an effective offering.
1480 Arthur Ave, Suite D
Louisville, CO 80027
25 Madison Road
Totowa, NJ 07512
tel. 800-716-7166
[email protected]
www.promotechdirect.com
DIRECTORY
Accelr8 Technology Corporation
Denver
www.accelr8.com
INDE X
38 Medical Device and Related Companies
Develops medical diagnostic technologies
for research and clinical applications. The
primary focus is rapid, integrated bacterial
analysis system designed to identify, count,
and provide complete antibiotic susceptibility
data by bacterial species within a few hours
of sample injection without prior culturing.
52 Biotechnology, Pharmaceutical and
Related Companies
63 Biofuels and Related Companies
65 Research & Education Institutions
68 Foundations
Accu-Tube Corporation
Englewood
www.accutube.com
69 Service Providers
Medical Device and
Related Companies
Abilities Unlimited
Colorado Springs, Denver
www.auiop.com
Provides artificial limbs and custom
orthopedic appliances.
Able Planet
Wheat Ridge
www.ableplanet.com
Able Planet and its award-wining LINX
AUDIO™ are changing the lives of millions
of people worldwide, one customer at a
time. Able Planet is developing an extensive
line of audio and communications products
that are usable by people with all levels of
hearing, and provide a means whereby users
can listen at lower volumes without compromising full rich sound. Able Customers
include all people who want access to audio
and communication devices, and with LINX
AUDIO™, “It is Possible™”. Able Planet
is rapidly expanding its product portfolio.
Please become a member by logging into our
website, and then visit us often to see what’s
new.
38
AbleLink Technologies
Colorado Springs
www.ablelinktech.com
Addresses the need for well-researched
cognitive support technologies for
individuals with intellectual disabilities.
About Packaging Robotics
Thornton
www.aboutpackagingrobotics.com
Produces robotic package handling systems.
The products are engineered to open, fill,
transport, seal, code and label a variety
of pre-made pouches and bags. Their line
of packaging and systems for on demand
product identification are currently used in
the medical, industrial and food industries.
Accellent
Englewood, Longmont
www.accellent.com
Accellent is the best provider of
comprehensive supply chain solutions,
and we are always striving to be more
responsive to our partners. With our
Accellent Focus we continue aiming at
doing just that.
Manufactures standard and custom size
stainless steel hypodermic medical tubing.
Actall Security Products
Denver
www.actallsp.com
Engineers, manufactures and markets
wireless systems for hospital and
pharmaceutical company facilities.
ADA Technologies, Inc.
Littleton
www.adatech.com
Designs and manufactures prosthetic and
orthotic components.
Advanced MicroLabs, LLC
Fort Collins
www.advancedmicrolabs.com
Researches and develops chemical
analytical instruments in ‘Lab-on-a-chip’
format.
Advanced Research Instruments
Corporation
Golden
www.aricorp.com
Produces preamplifiers for PMT’s and
electron multipliers, high voltage power
supplies, counters and timers, precision rate
meters, and image analyzers for scanning
electron microscopes.
2010/2011
BIOSCIENCE COLORADO
Aerophase, Inc.
Longmont
www.aerophase.com
Allogenesis LLC
Denver
www.genbiomed.com
Apdyne Medical Company
Denver
www.apdyne.com
Research and Development of technologies
that reduce environmental impact, help
economically disadvantaged people, and
improve healthcare. Including low cost,
environmentaly friendly Meter Dose Inhaler
and iproved Aerosol Therapy for Lung
Cancer
Created purified human platelet mixture
from platelets contained in blood (from
blood banks) that holds promise to replace
current growth media for stem cells. The
company’s pHMP product promises to
offer researchers more affordable animalfree option capable of working across
applications.
Manufactures and distributes the Apdyne
Phenol Applicator Kit used to anesthetize
the tympanic membrane during in-office
myringotomy procedures.
Aesthetic Technologies
Golden
www.atimed.com
Aqueous Biomedical
Colorado Springs
www.aqueousbio.com
Develops, processes and distributes lifeenhancing bone and tissue allografts to the
medical community.
Develops biocompatible materials and
geometric designs that can be applied to
stents, shunts, artificial organs and drug
delivery devices. Their first product, the
Oculieve™ shunt, is designed to control
over-pressurization inside the eye caused by
glaucoma.
Aestis, Inc.
Boulder
www.aestis.com
AllPro
Broomfield
www.allprodental.com
ArcScan, Inc.
Morrison
www.arcscan.com
Develops a treatment for obesity through
controlled hypoxia technology. The two
principal components are the air separation
unit and proprietary control system.
Produces a large selection of non-latex
prophy cups, prophy angles and other dental
products.
ArcScan, Inc. has developed break though
imaging technology for the eye. Many
ophthalmologists feel its patented Artemis
3 (shown above) VHF Ultrasound Arc
Scanner will change ophthalmology the way
MRI changed radiology.
Manufactures and sells Parisian Peel®
brand microdermabrasion systems and
accessories along with skin care products to
medical, and spa professionals.
AlloSource
Centennial
www.allosource.com
Alpha Mold West
Broomfield
www.alphamoldwest.com
Boulder
www.agilent.com
Provides core electronic and bio-analytical
measurement tools to advance life science
research.
AirLift Unlimited, Inc.
Evergreen
www.airlift.com
Develops and manufactures soft-sided
oxygen carriers.
Allergan, Inc.
Denver
www.allergan.com
Plastic injection mold-making facility for
the medical industry.
Analytical Systems Research, Inc.
Aurora
www.asremed.com
Analytical Systems Research, Inc. (ASR) is
a software development company seeking
to provide patient management tools to the
practicing physician. ASR seeks to offer the
medical community a new approach to the
EHR (Electronic Health Record) based on a
web-based, point-of-care software.
Continually conduct research to develop
products that enable medical specialists
to help people preserve and protect their
vision, move freely, best express their inner
beauty and lead healthy and active lives.
Animal Care Systems, Inc.
Centennial
www.animalcaresystems.com
Allison Medical Inc
Littleton
www.allisonmedical.com
Animark, Inc.
Aurora
www.animark.us
Develops products to assist specialists in the
medical and veterinary industries, and have
designed and provided essential syringes,
needles and custom items for various
industries.
Manufactures and sells ultrasound
pregnancy detectors and ovulation
predictors for livestock breeding.
BIOSCIENCE COLORADO
2010/2011
Provides innovative rodent caging systems
for the life-science industry.
Aspire Biotech, Inc.
Colorado Springs
www.aspirebiotech.com
Provides contract services for all phases
of product development from concept to
launch, and produces its own skin sealant
and wound-closure adhesives.
Auri-Stim Medical
Denver
www.net1device.com
Offers an alternative therapy for migraine
headaches, hormonal migraine, chronic
headaches, premenstrual syndrome (PMS),
nicotine and narcotics addictions using the
NET-1000 device.
Avantes
Broomfield
www.avantes.com
Produces, develops and sells spectrometers,
light sources, fiber optic multiplexer,
fiber optic cables, software, fiber optics,
accessories to the medical device industry.
39
Bal Seal Engineering, Inc.
Colorado Springs
www.balseal.com
BioCare Systems, Inc.
Parker
www.biocaresystems.com
BioVision Technologies, Inc.
Golden
www.biovisiontech.com
Produces seals and canted-coil springs for
sealing, holding, latching, and electrical
contact in a variety of applications
throughout the medical market.
Designs, develops and markets patentprotected, FDA cleared, new health-care
devices (LumiWave™) that use deep-tissue
light therapy to decrease pain, accelerate
healing and improve quality of life.
Develops and manufactures microvisualization solutions that enable
endoluminal and minimally invasive
medical procedures in both human
and veterinary medicine. The imaging
technologies and customized microendoscope solutions are integrated to reduce
incision size and speed healing.
Baxa Corporation
Englewood
www.baxa.com
Develops and manufactures products
for preparing, handling, packaging and
administering fluid medications.
Beacon Biotechnology
Aurora
www.beaconbiotechnology.com
BP Proteomics, ProLume Ltd, and Black
Forest Engineering, LLC have come
together to create Beacon Biotechnology to
pursue new opportunities that build upon
their respective scientific expertise.
BeamOne, LLC
Denver
www.beam-one.com
Biodesix, Inc.
Aurora, Broomfield
www.biodesix.com
Provides clinically reliable methods for
the early detection, diagnosis, therapeutic
guidance, and monitoring in cancer and
degenerative diseases.
Biofeedback Systems, Inc.
Boulder
www.users.qwest.net/~pitchj
Designs, manufactures, sells and services a
line of biofeedback hardware and software
including subliminal and supraliminal audio
self-help cassette programs. The company
is an FDA registered medical device
manufacturer.
Boulder Innovation Group, Inc.
Boulder
www.boulderinnovators.com
Develops and manufactures image-guided
surgical navigation digitizers and industrial
3D capture and modeling equipment.
Braun BioSystems, Inc.
Centennial
www.braunbiosystems.com
Provides diagnostic point of care coagulation management systems that have a positive impact on patient outcomes in hospital,
outpatient, and home healthcare venues.
Offers electron beam sterilization for
medical and pharmaceutical devices.
Bio-Logistics Preclinical, Inc.
Pierce
www.bio-logistics.com
Beckman Coulter
Fort Collins
www.beckmancoulter.com
Offers engineering and regulatory support
and preclinical strategic development to the
medical device industry.
Develops and produces instruments for the
diagnostic industry. Specializes in the fields
of immunocytochemistry, flow cytometry,
and microbiology.
BiOptix LLC
Boulder
www.alphasniffer.com
Bell Dental Products, LLC
Englewood
www.belldental.com
Develops technologies to detect trace
amounts of bacteria, viruses, proteins,
nucleic acids, antibodies and human micro
RNA’s.
Offers ceramic manufacturing, materials
expertise, and custom engineering support
to prototype and commercialize designs and
patents to orthopedic companies for hip,
spinal and dental implants.
Biotricity Medical Inc.
Aurora
www.biotricitymedical.com
Canberra Industries
Greenwood Village
www.canberra.com
Research and manufacturing company
specializing in developing long-term power
requirements for implanted devices based
on bioelectric generation.
Manufactures and supplies analytical
instruments, systems and services
for radiation detection and radiation
monitoring.
Designs, develops, and manufactures
precision dental equipment based on
electric motor technology.
Byers Peak
WheatRidge
http://byerspeak.com
Leading contract manufacturer of low to
medium volume, complex products for
the medical device, biotech and industrial
instrumentation markets.
Broadwest Corporation
Denver
www.broadwest.com
Develops and manufactures ergonomic
mammography viewing equipment.
C5 Medical Werks
Grand Junction
www.c5medicalwerks.com
Car-May L.L.C.
Berthoud
www.car-may.com
Unlike basic metering pumps, Car-May’s
systems provide pumping capability, fluid
measurement, and flow control all in one
compact module.
40
2010/2011
BIOSCIENCE COLORADO
Care Electronics, Inc.
Boulder
www.medicalshoponline.com
Certol International, LLC
Commerce City
www.certol.com
ColdQuanta, Inc.
Boulder
www.coldquanta.com
Offers a range of electronic monitoring and
alarm equipment for the home health and
long term care markets.
Provide patients and healthcare
professionals with innovative products and
responsible solutions to the complicated
infection control challenges of the 21st
century.
Focuses on the development of BEC (BoseEinstein Condensate) generating devices
and systems, allowing them to be accessible
to a wide range of research, educational,
and industrial institutions. Our products are
intended for use in scientific and industrial
applications requiring high performance
and reliability.
CaridianBCT
Lakewood
www.caridianbct.com
Develops and manufactures automated
blood collection systems and related
information systems. Developing cancer
therapies and vaccines through therapeutic
apheresis and cell therapy. Developing
pathogen reduction technologies.
Clarimedix, Inc.
Boulder
www.clarimedix.com
Develops quantum devices for the
temporary relief of minor muscle and joint
pain, arthritis, muscle spasms and stiffness.
Clean Room Devices, LLC
Westminster
www.cleanroomdevices.com
Caroba Plastics, Inc.
Englewood
www.caroba.com
Provides custom injection molds and
specializes in the needs of the medical and
high technology industries.
Carsan Engineering, Inc.
Golden
www.carsaneng.com
Designs and manufactures products
for several of the leading OEMs in the
medical, dental, industrial, semiconductor,
entertainment, and video projection
markets.
CEA Technologies, Inc.
Colorado Springs
www.ceatechnologies.com
Provides product development and complete
product assembly and packaging services to
the medical industry.
CeraPedics, Inc.
Westminster
www.cerapedics.com
Globally supplying the orthopedic and
spinal communities with quality products,
services and educational opportunities to
improve patient outcomes
CereScan
Denver
www.cerescanimaging.com
Manufactures products that are engineered
specifically for “clean room” environments.
Clifford Consulting & Research, Inc.
Colorado Springs
www.ccrlab.com
Clifford Materials Reactivity Testing
(CMRT) is a laboratory screening process
used to help identify existing sensitivity
problems to various chemical groups and
families of compounds in an individual
patient. This process is currently being
implemented in the CMRT Dental and
Orthopedic panels.
Cobe Laboratories, Inc.
Lakewood
303-232-6800
EtO (ethylene oxide) sterilization facility
with services offered to third party
customers. Has fulfilled requirements for
EPA, FDA, ISO and OSHA compliance.
(Owned Subsidiary of Gambro AB)
Cochlear Americas
Centennial
www.cochlearamericas.com
Designs, manufactures and distributes
hearing implants including the Nucleus
Freedom and Baha implants.
Colorado Laser Technologies, Inc.
Colorado Springs
www.coloradolasermarking.com
Provides YAG laser engraving technology,
as well as CO2 and YAG laser cutting
services.
Colorado Precision Products, Inc.
Boulder
www.coloradoprecision.com
Provides diamond turned and polished
optics/parts. Fabricator of X-ray telescope
optical components. Produces and offers air
bearing LVDT contact linear measurement
systems, .05 microinch resolution.
Colorado Scientific
Denver
www.vibemachine.com
Offers a vibrational integrated bio-photonic
energizer device that brings the vibrational
level of a person’s body back to its natural
state.
COMEG U.S.A. Endoscopy, Inc.
Denver
www.comeg.de/eng
A product range producing high quality
video imagery that meets the needs of the
surgeons in terms of products, budget and
services, whatever their specialty.
Confi-Dental Products Company
Louisville
www.confi-dental.com
Manufacture a wide range of dental and
healthcare products including composites,
cements, creams, lotions & ointments.
Denver-based corporation, in 2008, they
acquired the assets and imaging database of
Brain Matters Inc., a company previously engaged in providing functional brain imaging
for almost five years. Anticipates opening 20
additional centers across the nation.
BIOSCIENCE COLORADO
2010/2011
41
CONMED Electrosurgery
Centennial
www.conmed.com
Darkhorse Technologies
Boulder
[email protected]
DNTLworks Equipment Corporation
Centennial
www.dntlworks.com
Designs and manufactures RF
electrosurgical generators and accessories
of the highest quality, safety and value for
use in surgical procedures performed in
virtually every hospital, surgery center and
physicians office.
Commercializes a patented technology for
affordable, hand-carried, battery operated
instruments for on-site genetic detection
using Polymerase Chain Reaction (PCR).
Manufactures portable, mobile and selfcontained dental systems.
CoorsTek
Golden
www.coorstek.com
Using our core strengths of custom
engineering, materials expertise, operational
excellence, and rapid execution, we help
our customers develop amazing solutions
to their toughest technical challenges. Our
experienced engineering and manufacturing
experts are ready to help with your next
project.
Corgenix Medical Corporation
Broomfield
www.corgenix.com
The Colorado facility is engaged in
research, development, manufacture, and
marketing of in vitro diagnostic products for
use in disease detection and prevention.
Covidien
Boulder
www.covidien.com
Offers an extensive product line, including
pulse oximetry and airway and temperature
management devices, ventilators, vessel
sealing, and electrosurgery equipment.
Crosstrees Medical, Inc.
Boulder
www.xtreesmed.com
Aims to improve the quality of patient care
by developing the next generation platform
for percutaneous vertebral augmentation.
DataWave Technologies Corporation
Berthoud
www.dwavetech.com
Manufactures a wireless and battery-free device for acquiring and transmitting data from
electrodes and other biosensors to a receiver
placed meters away for electrophysiology,
neurophysiology and physiology related
research on both humans and large animals. Delphi Medical Systems
Longmont
www.delphimedical.com
Delphi, a leading automotive supplier,
has invested its knowledge in the medical
device industry through Delphi Medical
Systems, a wholly-owned subsidiary.
Denver Instrument Company
Denver
www.denverinstrumentusa.com
Designs and manufacturers analytical
balances, electrochemistry instruments,
moisture analyzers, and titration controllers.
Denver Optic Company
Englewood
www.eyeprosthetics.com
Specializes in the fitting and fabrication of
two types of ocular prosthesis.
Desert Glass Works
Colorado Springs
www.dgw.com
Manufactures quartzware for the medical
and research industries.
Cryenco/Chart Denver
Denver
www.cryenco.com
Die Cut Technologies
Northglenn
www.diecuttech.com
Chart Denver provides manufacturing
services to companies who want to outsource some or all of their manufacturing
processes, and to companies that have
capacity issues with their current
manufacturing resources.
Offers precision material conversion, skilled
assembly and manufacturing efficiencies,
including cleanroom facilities.
Directed Energy Solutions
Colorado Springs
www.denergysolutions.com
Develops advanced laser and optical device
solutions for medical applications.
42
dpiX, Inc.
Colorado Springs
www.dpix.com
Produces high-resolution amorphous silicon
(a-Si) sensor arrays for medical X-ray
imaging.
E.I. Medical Imaging
Loveland
www.eimedical.com
Manufacturer of highly portable and
ruggedized ultrasound devices for the
veterinary industry. E.I. Medical Imaging
engineers, manufactures and services these
devices in Loveland, Colorado
E.N. Murray Company
Denver
www.enmurray.com
Develops cellular foam technology for the
Eldon James Corporation
Loveland
www.eldonjames.com
Designs and manufactures a diverse line of
plastic and stainless steel hose fittings with
a single-barb design.
Electronic Materials, Inc. (EMI)
Breckenridge
www.emiuv.com
Offers a complete line of EMCAST UV
adhesives, epoxies, sealants, encapsulants
and coatings, EMI also offers room
temperature, thermal and Visible light cure
adhesive systems.
Ellab, Inc.
Centennial
www.ellab.com
Manufactures thermal validation solutions
for food and pharmaceutical industries.
Empirical Testing Corporation
Colorado Springs
www.empiricaltesting.com
Provides medical device testing services
that add value throughout the product
development cycle, with a focus on spinal
implant device testing.
2010/2011
BIOSCIENCE COLORADO
Encision, Inc.
Boulder
www.encision.com
Falcon Rehabilitation Products
Denver
www.falconrehab.net
nathodontics, Ltd.
Lakewood
www.gnatho.com
Designs and manufactures innovative
surgical devices. Developed AEM®
Laparoscopic Instruments to improve
electrosurgery and reduce the chance for
patient injury in minimally invasive surgery.
Designs and builds high quality, innovative
quadriplegic seating systems and
accessories (Falcon Rehabilitation Products,
LaBac Seating Systems, Gel Ovations).
Specializes in functional dentistry, advanced
implant work, precision partial dentures,
combination cases and metal-free fixed
restorations.
Firefly Medical, Inc.
Fort Collins
www.fireflymedical.com
Great Basin Scientific
Longmont
www.gbscience.com
Designs and develops innovative durable
medical equipment for clinical healthcare
markets.
Technology entails an integrated disposable
cartridge containing all necessary reagents
and an inexpensive benchtop analyzer that
executes the assay, interprets the results and
provides electronic output to the clinician
that is fast, accurate, cost-effective and
easy-to-use.
EndoShape, Inc.
Boulder
www.endoshape.com
Manufactures surgical and medical
instruments focusing on shape memory
polymer devices for endolumenal
application.
Eurofins Medinet
Aurora, Longmont
www.eurofins-medinet.com
Offers a full range of safety parameters and
biomarkers, genomic testing, microbiology
testing and highly specialized bioanalytical
services.
Evergreen Research, Inc.
Golden
www.evergreenresearch.com
Eveia Medical
Boulder
www.eveiamedical.com
Development stage company focused on
creating a bioanalytical system designed
to conduct immunassay tests. Ky attributes
include; lowfemtomolar sensitivities, short
assay development cycles and results in
10-20 minutes. The product consists of the
instruments, software and reagents required
for analyte measurement.
Extreme Diagnostics
Boulder
www.extremediagnostics.com
Fluonic
Boulder
www.fluonic.com
Gambro Americas
Lakewood
www.usa-gambro.com
Hach Company
Loveland
www.hach.com
Manufactures and distributes analytical
instruments and reagents used to test
the quality of water and other aqueous
solutions.
HEI Advanced Medical Operations
Boulder
www.heii.com
Develops and supplies hemodialysis,
peritoneal dialysis and acute dialysis
products, therapies and services.
Develops and manufactures high
performance components, medical software,
medical devices, and non-medical products.
Produces microcircuits and subsystems for
hearing and medical applications.
GE Analytical Instruments
Boulder
www.geinstruments.com
Hirsh Precision Products, Inc.
Boulder
www.hppi.com
Manufactures instruments used to measure
total organic carbon (TOC) in water for
pharmaceutical applications and medical
research.
Manufactures precision-machined and assembled components for the medical industry.
Genesee BioMedical, Inc.
Denver
www.geneseebiomedical.com
Manufactures cardiac surgery instruments
and devices.
Develops noninvasive measurement
systems, including optical systems such
as custom holographic and interferometric
instruments. Specializes in structural health
monitoring, nondestructive testing, and
materials processing.
2010/2011
Designs, manufactures, and markets
imaging systems for the screening and
diagnosis of breast cancer.
Develops infusion therapy systems with
disposable sensors for OEM and proprietary
pumping systems.
Offers a complete range of development
services from product definition and
feasibility studies through detailed design to
pilot-run and low-volume production to the
BIOSCIENCE COLORADO
Fischer Medical Technologies, Inc.
Broomfield
www.fischermti.com
Global Therapeutics
Broomfield
www.gtcardio.com
Balance Medical, Inc.
Boulder
www.ibalancemedical.com
Develops a solution for knee malalignment
that preserves and restores natural knee
surfaces. The Axial Knee Realignment
System (AKRFX) comprises both a new
surgical technique and an anatomic-based,
knee implant system.
A Broomfield-based Cook Medical
company that specializes in cardiology, was
give the go-ahead on a new coronary stent.
43
Illumasonix LLC
Aurora
www.alliedminds.com/Portfolio/
Illumasonix/index.htm
InVitria
Fort Collins
www.invitria.com
Lanx, LLC
Broomfield
www.lanx.com
In partnership with Allied Minds, we
will develop and commercialize a new
non-invasive vascular disease detection
procedure which will provide near real-time
assessment of detailed blood flow patterns
within the cardiovascular system.
InVitria develops, manufactures and
markets a portfolio of high performance
and well defined cell culture products
and reagents used in bioprocessing,
biopharmaceutical formulation, stem cell &
regenerative medicine, life science research
and diagnostics.
Specializes in systems and implants for
all segments of spinal surgery. Integrating
leading technology, intellectual property
and state-of-the-art engineering, each
product is designed to simplify surgery
and improve the quality of care for patients
worldwide by providing surgeons with
innovative spinal products.
InDevR, Inc.
Boulder
www.indevr.net
IPAX, Inc.
Englewood
www.ipaxinc.com
Develops and manufactures biomedical
instruments including molecular diagnostic
assays, virus measurement systems and
detection technologies for micro-arrays.
Assembles and packs medical products,
focusing on bringing new medical products
to the marketplace. Specialty is small to
medium production runs, also has the
capacity and the manpower to take on the
larger jobs.
Infinity Photo-Optical Company
Boulder
www.infinity-usa.com
Manufactures long-distance and
continuously-focusable microscope
technology, macro systems, internalfocusing devices and other lenses.
Injectech, LLC
Loveland
www.injectech.net
Provides molding, assembly and design
of medical components and fittings for
OEM device manufacturers. Class 100,000
cleanroom molding and assembly available.
Instec, Inc.
Boulder
www.instec.com
Manufactures precision temperature
controllers and microscope hot stage
systems for temperature cycling, food
sciences, materials characterization,
forensics, polymers and liquid crystals and
microbiology.
Intertek
Boulder
www.intertek.com
Offers testing, inspection and certification
of products, commodities and systems for
medical devices. Performs FDA 510(k)
reviews, electrical safety certification
including CE Marking, testing to the
MDD and IVDD, risk analysis, EMC and
performance testing.
44
Jorgensen Laboratories, Inc.
Loveland
www.jorvet.com
Designs and manufactures instruments
which are used in the animal health field
including specialty instruments, surgical
suture, and veterinary equipment.
Kestrel Labs, Inc.
Boulder
www.kestrellabs.com
Kestrel Labs combines internal research and
development projects with consulting and
contract development of innovative, patient
monitoring concepts and other medical
technologies.
Kent Systems
Loveland
www.kentsystems.com
KENT Systems designs, manufactures, and
distributes Plastic Quick Couplings, Tube
Fittings, and Media Bags. All our products
are made in Colorado!
Kimble Precision, Inc.
Loveland
www.kimble-precision.com
Provides general machining, short run
production of existing products, prototyping
of new products, as well as fixturing and
tooling.
Leap Frogg, LLC
Grand Junction
970-260-7494
Created The Frogg Dynamic Compression
System which can be used at all times;
no gaps in protection; reduces accidents;
reduces nursing time; is more comfortable.
Laser Neurotherapy Development
Labs, Inc.
Colorado Springs
www.laserneurotherapy.com
While high-intensity lasers are best known
in their applications as precision surgical
tools, Laser Neurotherapy Development
Labs has discovered the biostimulative
value of high energy laser radiation. The
Neurolase™ direct high level,
monochromatic, continuous-wave optical
radiation to pathological tissue to restore
and improve function.
Leeds Precision Instruments, Inc.
Denver
www.leedsmicro.com
Offers microscopes and custom-engineered
products ranging from small modifications
on a microscope stand that accommodate
specific applications, to large specialized
systems, such as an optical comparison
bridge for forensic science.
Lenox MacLaren Surgical
Instruments
Louisville
www.lenoxmaclaren.com
Manufactures precision orthopedic and
neurological surgical instruments.
2010/2011
BIOSCIENCE COLORADO
Lexicor Medical Technology LLC
Boulder
www.lexicor.com
Develops neuropsychiatric medical devices,
such as Neba™ an experimental, small
format EEG-based device being studied
under an Investigational Device Exemption
from the Food and Drug Administration.
Locomotion Inc.
Nederland
http://locomotiondevices.com
mBio Diagnostics (a division of
Precision Photonics Corporation)
Boulder
www.mbiodx.com
Develops a low-cost, high sensitivity, multipathogen detection system for diagnostics.
MedEfficiency, Inc.
Wheat Ridge
www.medefficiency.com
Specializes in total contact casting products
for off-loading diabetic foot ulcers.
Locomotion’s vision is to be a leading
provider of specialized equipment that helps
people improve their daily lives through
physical rehabilitation.
Medical Modeling, Inc.
Golden
www.medicalmodeling.com
Produces highly accurate 3-D physical
models of human bone structure from
imaging such as CT or MRI.
Logisens Corporation
Fort Collins
www.logisens.com
Develops biosensor and software
technology, enabling a significant
breakthrough in real-time measurement and
reduction of stress.
Magnelab, Inc.
Longmont
www.magnelab.com
Manufactures custom magnetic components
(transformers/inductors) for the medical
field.
Massively Parallel Technologies, Inc.
Boulder
www.massivelyparallel.com
Focuses on the entire communication task
at the cluster level, and optimize it mathematically (22 patents granted or pending);
Rigorous algorithms allow a system to manage itself and adapt to changing requirements, at any scale; Libraries self-train on a
given hardware configuration, so there is no
tradeoff between optimality and generality.
Mayer Medical Technologies, Inc.
Grand Junction
www.mayermedical.com
Mayer Medical Technologies, Inc. improves
health and saves lives by innovating new
products, providing seed capital to medical
start-ups, and assisting medical professionals
in developing their product ideas.
Medivance, Inc.
Louisville
www.medivance.com
The Arctic Sun is the only non-invasive
product on the market specifically designed
to manage the core temperature of critically
ill patients. It is designed to mimic water
immersion, which is said to be the most
effective means of quickly decreasing core
body temperature.
Medtronic Navigation
Louisville
www.medtronicnavigation.com
At the forefront of surgical navigation
solutions, guiding the industry to a higher
standard of care for several clinical
specialties, including cranial neurosurgery,
functional neurosurgery, spinal, ENT,
joint replacement and orthopaedic trauma
surgeries.
Meinhard Glass Products
Golden
www.meinhard.com
Continues the evolution in nebulizer design.
The principle goal is to produce finer, more
narrowly sized-dispersed aerosols while
maintaining the high quality, low cost and
simplicity of design and operation that
characterize the MEINHARD® nebulizer.
Mesa Laboratories, Inc.
Lakewood
www.mesalabs.com
Provides dialysis meters and related
supplies to dialysis clinics world wide.
BIOSCIENCE COLORADO
2010/2011
Metafluidics, Inc.
Golden
www.metafluidics.com
An industry leader in microfluidic/optical
integration for sophisticated biomedical
diagnostic lab-on-a-chip applications.
Using novel optical trapping, fluorescence
detection and fluid control technology,
Metafluidics delivers point-of-care
cytometry and cell sorting solutions with a
minimum of user preparation or input.
Metamatrix, LLC
Boulder
www.zorbent.com
Manufacturers of ZORBENT which
absorbent is designed to leave no residue,
reducing the risk associated with slippery
surfaces and is completely safe to use and
represents no health hazard
Micro Imaging Solutions, LLC (MIS)
Englewood
www.micro-imaging.us
Developed an innovative-patented technology that can be utilized in the manufacture
of micro-digital CMOS cameras.
Microlife Medical Home Solutions, Inc.
Golden
www.mimhs.com
Microlife Medical Home Solutions is
dedicated to meeting the needs of healthcare
providers and their busy medical practices.
Our proprietary hand-held medical devices
and systemic solutions offer healthcare
providers evidence-based and practicetested methods for accurate assessment,
diagnosis, and treatment of cardiovascular
and metabolic diseases.
MicroPhage, Inc.
Longmont
www.microphage.com
Produces high-speed bacteria detection
technologies to commercialize in markets
including: food safety, water safety, clinical
and veterinary diagnostics and detection
applications.
Mikron Corporation Denver
Aurora
www.mikron.com
Supplies transfer machining systems for
complex parts, cutting tools with high
performance standards, self medication and
diagnostic devices.
45
Mind Studios
Colorado Springs
www.mind-studios.com
Otologics, LLC
Boulder
www.otologics.com
Peddle Master, Inc.
Johnstown
www.peddlemaster.com
A full service product design and research
studio housed within the University of
Colorado at Colorado Springs. Offers
concept generation, advanced prototyping,
engineering and consumer research, human
factors design and manufacturing solutions.
Develops and commercializes surgically
implantable alternatives to conventional “in
the ear” hearing aids. Designs and manufactures handicapped
driving aids. The Peddel Master is totally
portable and can be installed and removed
in a matter of seconds.
Mountainside Medical
Boulder
www.mountainsidemed.com
Produces induction loop assistive listening
systems and visual and vibrotactile
technologies that help deaf and hard of
hearing individuals.
Specializes in the contract manufacturing
of medical device components and
instruments, including electrosurgical
and laparoscopic instruments and jaws,
orthopedic implants, endoscopy devices.
NeuroQuest Therapeutics
Grand Junction
www.Nqtherapeutics.com
Develops an electrical brain stimulating
device to deliver neuromodulation
treatments to address the unment
therapeutic needs of nervous system
disorders, stroke recovery, chronic pain and
behavioral disorders.
nSpire Health, Inc.
Longmont
www.nspirehealth.com
Develops, manufactures and markets
respiratory care products and services
focused on cardiopulmonary diagnostics,
respiratory core lab services, and disease
management solutions.
Olympus Soft Imaging Solutions
Corporation (OSIS)
Lakewood
www.soft-imaging.de
Produces, markets, and sells image acquisition and processing software and hardware
for all areas of electron microscopy.
Optibrand Ltd., LLC
Fort Collins
www.optibrand.com
Provides a fraud-resistant system to
positively identify animals from birth and
throughout the food processing chain. The
Secure Identity Preservation system helps
assure food safety and control the spread of
animal disease.
46
Oval Window Audio
Nederland
www.ovalwindowaudio.com
Paré Surgical, Inc.
Centennial
www.paresurgical.com
Develops surgical instruments such as the
Quik-Stitch endoscopic suturing system.
Parker Medical
Highlands Ranch
www.parkermedical.com
Pernicka Corporation
Fort Collins
www.pernicka.com
Offers analytical testing that meets or
exceeds the requirements of MIL-STD
750/883 method 1018 and 45662A for
companies in the semiconductor, aerospace,
basic & applied research, surface analysis,
thin film deposition, laser technology, and
medical products industries.
PharmaJet, Inc.
Golden
www.pharmajet.com
Provides airway management products that
make intubation safer for the patient and
easier for the medical professional.
Develops a needle-free technology that
has a low cost, single use, disposable
polypropylene vial or cartridge, suitable
for the delivery of common vaccines and
standard dose injectable liquid medicines.
Particle Measuring Systems
Boulder
www.pmeasuring.com
Phillips Plastics (Farley Sales Group)
Denver
www.phillipsplastics.com
Designs, manufactures, and services
precision microcontamination monitoring
instrumentation and software used for
detecting particles in aerosols, liquids,
slurries, gas streams and vacuum processing
environments as well as surface molecular
contamination monitoring.
Phillips Plastics Corporation offers injection
molding from design through distribution
PCC/Advanced Forming Technology
Longmont
www.pcc-aft.com
Offers thixoforming and metal injection
molding for the medical device industry.
Peak Robotics, Inc.
Colorado Springs
www.peakrobotics.com
Manufactures robots, special equipment,
and turnkey automated systems for a variety
of industries including: biotech, electronics,
medical, semiconductor, etc.
Physical Activity Innovations
Fort Collins
970-217-9340
Developing unique, footwear-based systems
that motivate users to increase their daily
physical activity.
Pico-Tesla Magnetic Therapies, LLC
Littleton
www.pico-tesla.com
Manufactures, markets and supports
proprietary medical device technology
designed to treat the signs and symptoms
of neurological disorders like Parkinson’s
disease, Alzheimer’s, migraines and
epilepsy.
Plexus Corporation
Louisville
www.plexus.com
Provides integrated product development,
manufacturing, and sustaining services of
medical products.
2010/2011
BIOSCIENCE COLORADO
PolyNEW, Inc.
Golden
www.polynewinc.com
Prescott’s, Inc.
Monument
www.surgicalmicroscopes.com
Develops Polymer ice and methods of
making and using them.
Provides reconditioned operating
microscopes and allied accessories that
function as intended by the original
equipment manufacturer.
Porta-Lung, Inc.
Lakewood
www.portalung.com
Provides non-invasive ventilator support
for long-term patients who need more
portability than the iron lung allows, while
maintaining the same level of ventilating
efficiency.
Precision Biopsy
Aurora
www.alliedminds.com/Portfolio/Precision_
Biopsy/index.htm
In partnership with Allied Minds, we are
working to develop and commercialize
technology for the accurate diagnosis
of prostate cancer which uses advanced
spectroscopy imageing techniques in
combination with tissue biopsy.
Precision Diagnostic Instruments
Westminster
www.pdimeters.com
Designs and manufactures professional
quality, affordable test equipment.
Precision Glassblowing
Centennial
www.precisionglassblowing.com
Provides custom and OEM scientific glass
for custom synthesis, pharmaceutical,
environmental, petrochemical, research,
commercial, government and medical
laboratories.
Precision Photonics Corporation
Boulder
www.precisionphotonics.com
provide price-competitive laser optics
and coatings to the telecommunications,
defense, aerospace, biomedical, and
semiconductor industries.
Preferred Medical Products, Inc.
Englewood
www.pmpcolorado.com
Manufactures stainless steel medical
components for hypodermic needles and
lancet type products.
BIOSCIENCE COLORADO
2010/2011
Probetronix, LLC
Colorado Springs
www.probetronix.biz
Manufactures oscilloscope probes.
Products Group International, Inc.
Lyons
www.productsgroup.com
Researches, develops and engineers
ultrasound medical and veterinary
equipment.
Protogenic, Inc. (a division of
Spectrum Plastics Group)
Westminster
www.protogenic.com
Quest Product Development
Corporation
Wheat Ridge
www.quest-corp.com
Helps bring to market medical products
and analytical systems for small start-ups
to research universities and international
corporations. Has received numerous
SBIR/STTR grants from NIH, DOD, NASA
and NIST.
Radiological Imaging Technology, Inc
Colorado Springs
www.radimage.com
Provides clinical and research physicists
with a high precision automated QA tool
for advanced radiation therapies. Received
FDA clearance on RIT113 radiation therapy
film dosimetry.
Rand-Scot, Inc.
Fort Collins
http://randscot.com
Manufactures prototypes and conceptual
models using stereolithography (SLA) and
Laser Sintering (LS) rapid prototyping
technology.
Designs and manufactures products for
persons with disabilities including BBD
Cushions and Mattress Overlays, EasyPivot
Patient Lifts, and Saratoga Exercise
Products.
Protomed, Inc.
Westminster
www.protomed.net
Rapid Prototying Corporation
Longmont
www.rapidpro.com
Creates accurate anatomical models from
CT scans by using the latest imaging
software and laser driven technology.
Offers engineering and design and other
manufacturing services for the medical
device industry.
Prototype Casting, Inc.
Denver
www.protcast.com
RJD Machining
Parker
www.rjdmachining.com
Manufactures non-ferrous prototype parts
for the medical industry, specializes in RPM
(Rubber Plaster Mold) casting, sand casting
and rapid investment casting.
Specializes in precision production runs
and some prototype work for OEM’s in the
medical industry.
PTA Corporation
Longmont
www.ptacorp.com
Manufactures aluminum and steel molds
for projects with lifetime runs of 5,000 to
250,000 pieces for medical applications.
Rocky Mountain Biosystems, Inc.
Wheat Ridge
www.rmbi.net
Develops a tissue sealing technology that
activates a specially formulated adhesive
to bond tissue and achieve a uniform seal
in seconds. The systems temporarily or
permanently modify tissues for transdermal
and deposition drug delivery, and for
cosmetic skin resurfacing.
47
Rocky Mountain Instrument Company
(RMI)
Lafayette
www.rmico.com
Designs and manufactures optics and
coatings (ultraviolet through far infrared)
for the medical industry.
Rocky Mountain Orthodontics, Inc.
(RMO)
Denver
www.rmortho.com
Serves all areas of orthodontics including
pediatric orthodontic prevention, interceptive pediatric orthodontics, mixed dentition
orthodontics, adult orthodontics, reconstructive dentistry orthodontics, TMJ orthodontics, surgical orthodontics and breathing/sleep problem related orthodontics.
Samson Design Associates, Inc.
Boulder
www.samsondesign.com
Provides full service product development
ranging from concept to production
specifications, with many products for the
medical field.
Sandhill Scientific
Highlands Ranch
www.sandhillsci.com
diagnostic products focused on
gastroenterology.
Sealcon
Centennial
www.sealconusa.com
Sorin Group
Arvada
www.sorin.com
Manufactures cable management
components, including liquid tight strain
relief fittings, flexible conduit, M23 circular
connectors and related products for the
health care industry.
Develops and produces cardiovascular and
autologous transfusion therapy products.
Shippert Medical Technologies Corp.
Centennial
www.shippertmedical.com
Offers ultrasonic technologies and related
techniques for aesthetic surgery.
Manufactures and distributes medical
disposable products and instruments. Serves
the ear, nose and throat, plastic surgery,
cosmetic surgery, emergency/trauma care,
family practice, pediatric, ophthalmology
and dermatology fields.
Sienco, Inc.
Arvada
www.sienco.com
Manufactures and distributes Class II
medical devices, disposable supplies,
reagents and accessories for in-vitro
diagnostic use. Also, provides tools for
hemostasis monitoring and viscoelastic
evaluations.
Snoasis Medical
Denver
www.snoasismedical.com
Develops dental regenerative products
derived from discarded tissues and cells.
Science Care
Aurora
www.sciencecare.com
SomaLogic, Inc.
Boulder
www.somalogic.com
Provide human tissue for medical research
and education. We serve as a link between
individual donors and medical researchers
and educators.
Uses aptamer array technology and
bioinformatics capabilities to discover
disease-specific biomarkers and protein
signatures. Develops medical diagnostics
based on these signatures.
Scientech, Inc.
Boulder
www.scientech-inc.com
Manufactures analytical instruments: semimicro balances, analytical balances, semianalytical balances, and toploading balances
for the medical industry.
Sonora Medical Systems, Inc.
Longmont
www.4sonora.com
Provides high quality products and services
to the diagnostic ultrasound and MRI markets. ISO 9001 certified and FDA registered.
Scott Orthotic Labs, Inc.
Fort Collins
www.scottorthotic.com
Sontec Instruments, Inc
Centennial
www.sontecinstruments.com
Manufactures Orthotic and Prosthetic
Components, Pre-fabricated Orthotics, and
Custom O&P Devices.
Provides a broad line of instruments as well
as custom instrument manufacturing and
in-house repair service.
48
Sound Surgical Technologies, LLC
Louisville
www.vaser.com
Source MDx
Boulder
www.sourcemdx.com
Develops RNA-based biomarkers to create
companion diagnostics for inflammation
related therapeutic areas including
oncology, cardiovascular, autoimmune and
infectious diseases.
Spectrum Laser & Technologies, Inc.
Colorado Springs
www.spectrumlaser.com
Provides contract design and manufacturing
services for the medical industry.
ST Cardio Technologies, LLC
Broomfield
www.stcardio.com
Designs, develops, and manufactures
electronic medical devices for use in
electrophysiology cardiac cath labs. Our Z6
Cardiac Stimulator is our first product and
has FDA 510(k) clearance.
St. Renatus, LLC
Fort Collins
www.st-renatus.com
First needle-free, dental anesthetic suitable
for use in procedures involving most of
the upper teeth. Uses an accurate and
sophisticated method to anesthetize the upper
teeth without the risk and pain of a needle.
StrionAir, Inc.
Louisville
www.strionair.com
Manufactures and markets a product that
uses disposable media and that can be installed in any air handler or HVAC system.
2010/2011
BIOSCIENCE COLORADO
Stroke Recovery Systems, Inc.
Denver
www.strokeaid.com
Synthes, Inc.
Monument
www.synthes.com
The Harloff Company
Colorado Springs
www.harloff.com
Develops the AutoMove AM800 that
teaches healthy parts of the brain after a
stroke to take over lost functionality.
Develops, produces and markets
instruments, implants and biomaterials
for the surgical fixation, correction and
regeneration of the human skeleton and its
soft tissues.
Manufactures and sells a line of crash carts,
medication carts and other specialty carts
for hospitals, nursing homes, clinics and
surgery centers.
Summa Design
Ridgway
www.summa-design.com
The Synaptic® Corporation
Aurora
www.synapticusa.com
Contract design and development company
focused on the medical device market.
TRS, Inc.
Boulder
www.oandp.com/products/trs
Summit Doppler Systems
Golden
www.summitdoppler.com
Develops, manufactures, and markets
body-powered prosthetic devices. Designs
and builds technology for persons missing
hands.
Develops Synaptic®, a patented pain
control technology that works without
drugs. Marketed in accordance with FDA
regulations for the treatment of acute and
chronic pain.
Tapeless Wound Care Products, LLC
Englewood
www.tapelesswoundcare.com
TheraTogs, Inc.
Telluride
www.theratogs.com
Manufactures and distributes a system
of patented secondary wound dressing
retention devices, offering an alternative to
traditional secondary wound dressings, for
both human and animals.
Produces an orthotic undergarment and
strapping system that gives clients with sensorimotor impairment a new modality for
improving postural alignment and stability.
Manufactures ultrasound Doppler systems
used to detect fetal heartbeat and to monitor
peripheral arterial and venous blood flow.
Sunrise Medical Inc
Longmont
www.sunrisemedical.com
Provides home healthcare products including wheelchairs, respiratory, daily living
aids, and speech augmentation devices.
Supreme Cable Technologies, Inc.
Thornton
www.supremecable.com
Manufactures quality custom cable
assemblies and wire harnesses.
Surgical Pioneering, Inc.
Monument
http://profitintelligence.com
Dedicated to improving the recovery
times and mortality rate of cardiovascular
surgery patients through groundbreaking
innovations in surgical equipment
and operative techniques.
Swan Valley Medical, Inc.
Aurora
www.swanvalleymedical.com
Swan Valley Medical has developed a line
of urology instruments that allow for safer,
faster, and more economical treatment of
common urological disorders.
Tartan Orthopedics, Ltd
Northglenn
www.tartanortho.com
Manufactures sacro lumbar belts, dorsal
lumbar belts (corsets and moldable
inserts), Ottenberg style elbow splint,
pelvic traction belts, arm slings, cervical
collars, acromioclavicular splints, and ankle
supports.
TDA Research, Inc.
Wheat Ridge, Golden
www.tda.com
Provides automated catalyst testing
equipment to large chemical companies and
national laboratories.
Tech-X Corporation
Boulder
www.txcorp.com
Specializes in scientific and engineering
software, including visualization and
algorithm development.
The Spectranetics Corporation
Colorado Springs
www.spectranetics.com
Tensegrity Prosthetics, Inc.
Boulder
www.tensegrityprosthetics.com
Develops, manufactures and markets singleuse medical devices used in minimally
invasive surgical procedures within the
cardiovascular system along with its CVX300® excimer laser system.
Develops a prosthetic foot that mimics the
functional biomechanics of the human foot
in walking.
BIOSCIENCE COLORADO
2010/2011
Tissue Genetics, Inc.
Aurora
www.tissuegenetics.com
Molecular diagnostics company with unique
technology for improving the care of patients with genetic diseases using biomarkers to identify patients with hereditary diseases and to determine the course of care.
TMJ Implants, Inc.
Golden
www.tmj.com
Designs and manufactures alloplastic
implants for the treatment of temporomandibular joint disorders and injuries.
Toltec International, Inc.
Lakewood
www.toltec.biz
Toltec provides medical device engineering
services compliant with US FDA and
international regulatory standards. We
assist medical device companies with
the development and maintainence of
medical devices in full compliance with the
regulations and standards.
49
Touch of Life Technologies, Inc.
(ToLTech)
Aurora
www.toltech.net
Develops procedural simulators in the
areas of orthopaedics, gastroenterology,
rheumatology, radiology, ophthalmology,
and general surgical procedures.
Transtracheal Systems, Inc.
Englewood
www.tto2.com
Develops and manufactures innovative respiratory therapy products that advance medical
therapy for persons requiring continuous
supplemental oxygen, including the SCOOP
transtracheal oxygen therapy system.
Trelleborg Sealing Solutions
Mountain
Broomfield
www.trelleborg.com/en
Supplies high-quality products and
solutions for industrial sealing and bearing
systems. Activities are focused in many
business areas including the food and
pharmaceutical industries, as well as
medical engineering.
Ultrathera Technologies, Inc.
Colorado Springs
www.ultrathera.com
Life sciences company dedicated to
improving human performance by applying
advanced technologies to physiological and
neurological needs. Maker of AeroStim™
and PointScribe™.
Value Plastics, Inc.
Fort Collins
www.valueplastics.com
Designs and manufactures plastic tubing
fittings and connectors.
ValveXchange, Inc.
Aurora
www.valvexchange.com
Develops a bioprosthetic heart valve with
a percutaneously-exchangeable leaflet set
that provides lifetime service without anticoagulation therapy.
50
VitruMed, Inc.
Boulder
www.vitrumed.com
Ximedix, Inc.
Colorado Springs
www.ximedix.com
Focused on the development of a
minimally-invasive radio frequency (RF)
tissue welding technology for pulmonary
resections including biopsies, to further
advance early detection and treatment of
lung cancer.
Manufactures and sells single patient
use medical products for the anesthesia,
respiratory care, critical care and emergency
medicine applications.
WalkMed Infusion, LLC
Englewood
www.walkmed.net
Offers solutions for ambulatory infusion
therapy and pain management.
WAVi Company
Boulder
www.ewavi.com
The platform is based on the
Electroencephalograph (EEG) that
integrates with physician diagnostic
tools and a research library. Helps with
interpretation and treatment of brain
ailments and performance including TBI,
PTSD, Alzheimer’s Age Management and
depression.
WestMed, Inc.
Greenwood Village
www.westmedinc.com
Yamato Corporation
Colorado Springs
www.yamatocorp.com
Manufactures and sells weighing equipment
and systems for medical facilities.
Zetek, Inc.
Aurora
www.zetek.net
Manufactures the OvaCue family of
ovulation prediction products. Zynex Medical, Inc.
Lone Tree
www.zynexmed.com
Offers electrotherapy products, utilizing
various methods of non-invasive muscle
stimulation and electromyography
technology, Interferential Current (IFC)
and Transcutaneous Electrical Nerve
Stimulation (TENS).
Designs, manufacturers and markets
medical devices to anesthesia and
respiratory professionals.
Westone Laboratories
Colorado Springs
www.westone.com
Designs and manufactures custom
earmolds for hearing healthcare and other
applications.
Wi LLC – Medical Device Product
Development
Englewood
www.wiinc.net
Designs and engineers medical devices.
Including innovative services such as laser
welding, assay design, and air bubble management.
2010/2011
BIOSCIENCE COLORADO
BIOTECHNOLOGY, PHARMA, AND RELATED
COMPANIES
Accera, Inc.
Broomfield
www.accerapharma.com
Discovers and develops innovative
therapeutic treatments for
neurodegenerative diseases,like Parkinson’s,
Alzheimer’s and other age-related memory
loss disorders.
Accuthera, Inc.
Denver
www.accutherainc.com
Develops therapeutics for acute and critical
care indications. Initial clinical indication is
acute lung injury caused by trauma and/or
serious infectious pathogens.
Advanced Regenerative Therapies
(ART)
Fort Collins
970-222-9831
Provides a stem cell isolation and expansion
service for companion animal medicine.
Boulder
www.agilent.com
Agilent Nucleic Acid Solutions
develops and manufactures therapeutic
oligonucleotide in a multi-product, 33,500
square foot facility.
Agripro COKER
Berthoud
www.agriprowheat.com
Develops and delivers superior wheat seed
genetics in North America.
AKTIV-DRY
Boulder
www.aktiv-dry.com
Provides dry powder processing solutions
for the vaccine, pharmaceutical, and
biotechnology industries.
Albany Molecular Research, Inc
(AMRI)
Denver
www.amriglobal.com
Performs services including drug discovery,
pharmaceutical development, and
manufacturing of active ingredients and
pharmaceutical intermediates for many of
the world’s leading healthcare companies.
BIOSCIENCE COLORADO
2010/2011
Allergan, Inc.
Denver
www.allergan.com
Anabolic Labs
Colorado Springs
www.anaboliclabs.com
Our R&D programs today are focused
in ophthalmology, neurosciences,
medical aesthetics, medical dermatology,
gastroenterology (obesity intervention),
and urological diseases. Currently, we are
investigating a rich arsenal of potential new
treatments for chronic migraine, debilitating
neurological conditions, eye disease, and
overactive bladder, among other conditions.
Focused line of nutritional products,
with state-of-the-art pharmaceutical
manufacturing facilities in California and
Colorado.
Allos Therapeutics, Inc.
Westminster
www.allos.com
Develops and commercializes small
molecule therapeutics for the treatment of
cancer.
Alpharma, Inc.
Longmont
www.alpharma.com
Manufactures generic liquid and topical
pharmaceuticals including nutritional
supplements, water-soluble pharmaceutical
products and disinfectants for veterinary
use.
American Allied Biochemical, Inc.
Aurora
www.aablabs.com
Animal Health Options
Golden
www.animalhealthoptions.com
Since 1990, Animal Health Options has
been offering high quality nutritional
supplements that meet or exceed industry
standards and provide a noticeable benefit
to dogs, cats and horses.
ApopLogic Pharmaceuticals, LLC
Aurora
www.apoplogic.com
Develops biotech drugs that take advantage
of understanding the receptors and ligands
that control natural cell death (apoptosis).
Aquatic BioSystems
Fort Collins
www.aquaticbiosystems.com
Specializes in the production and
distribution of freshwater and marine
organisms for aquatic toxicology,
biomonitoring and other research activities.
Specializes in the purification and
distribution of restriction endonucleases
enzymes.
ARCA biopharma, Inc.
Broomfield, Aurora
www.arcabiopharma.com
Amgen, Inc.
Boulder, Longmont
www.amgen.com
Specializes in developing and
commercializing genetically-targeted
therapies for heart failure and other
cardiovascular diseases.
Discovers, develops, manufactures and
markets human therapeutics based on
advances in cellular and molecular biology.
Amgen Colorado is one of the company’s
key operations centers, providing
EPOGEN®, Aranesp® and Kepivance™.
AmideBio, LLC
Boulder
www.amidebio.com
AmideBio’s proprietary platform vector
technology addresses the challenges
of historically difficult-to-manufacture
peptides by providing products that are
reliable (BioPure™), economical and
incorporate environmentally sustainable
practices.
Array BioPharma
Boulder, Longmont
www.arraybiopharma.com
Discovers, develops and commercializes
targeted small molecule drugs to treat
debilitating and life-threatening diseases
such as cancer.
ASDx Biosystems, Inc.
Boulder
www.asdxbio.com
Specializes in the development of
immunoassays for environmental
agents, foodborne pathogens, infectious
diseases and oncology biomarkers using
luminescence detection technologies and
dedicated luminometer instrument systems.
51
AspenBio Pharma, Inc.
Castle Rock
www.aspenbioinc.com
bioNovo
Aurora
www.bionovo.com
Bolder BioTechnology, Inc.
Boulder
www.bolderbio.com
Primarily focused on advancing towards
commercialization, our recently patented
blood-based human diagnostic test,
AppyScore™ to aid in the diagnosis of
human appendicitis and several novel
reproduction drugs for use in high value
animals.
Discovers and develops drugs for women’s
health, including menopause, osteoporosis
and cancer.
Uses advanced protein engineering
technologies to create proprietary human
protein pharmaceuticals with enhanced
therapeutic properties.
Astellas Pharma US, Inc.
Denver
www.astellas.us
Researches and develops pharmaceuticals
for select theraputic areas, including
Urology, Immunology, Dermatology,
Cardiology, and Infectious Diseases.
Aurogen
Fort Collins
www.aurogen.com
Produces a pharmaceutical treatment
for diabetic neuropathy, with a second
invention showing that neurotrophic
hormones can act across the blood-brain
barrier (BBB) to treat various brain
disorders.
Avidity, LLC
Aurora
www.avidity.com
Licenses the patented biotin-accepting
peptides (AviTag) technology which
exploits the tight interaction of avidin or
streptavidin with biotin for immobilizing,
purifying and visualizing proteins.
BaroFold, Inc.
Aurora
www.barofold.com
Discovers, develops and commercializes
protein biologics. The pipeline contains
therapeutics with an immunology focus,
including Multiple Sclerosis, Rheumatoid
Arthritis, and Asthma.
BioAMPS Internatitonal, LLC
Aurora
www.bioamps.com
Focused on the discovery, development
and commercialization of proprietary
antimicrobial peptide (AMPS) therapeutic
solutions for the treatment of systemic
infectious diseases, including methicillinresistant Staphylococcus aureus (MRSA)
and other resistant gram-negative and gram
positive bacteria.
52
BioResponse, LLC
Boulder
www.bioresponse.com
Researches, develops and commercializes
dietary supplements for better absorption
and functional foods.
BioServe Space Technologies
Boulder
www.colorado.edu/engineering/BioServe
Researches space life science with
a wide range of biotechnology
applications involving animals, plants and
microorganisms. Specializing in conducting
microgravity life science research and
designing and developing space flight
hardware.
Biosyntrx Inc.
Colorado Springs
www.biosyntrx.com
Develops nutraceuticals to address the
micronutrient needs of the dry eye, cataract,
macular degeneration, glaucoma and
diabetic retinopathy patient.
Biotest Laboratories, LLC
Colorado Springs
www.biotest.net
Manufactures and distributes dietary
supplements.
BodySync, Inc.
Aurora
www.bodysync.com
Applies evidence-based genetic information
to develop personalized products that help
individuals achieve their health goals.
BodySync, Inc. purchased some of Sciona’s
assets recently.
Bolder BioPATH, Inc.
Boulder
www.bolderbiopath.com
Boulder Scientific Company
Mead
www.bouldersci.com
Provides organometallic compounds to the
pharmaceutical, polymer, and specialty
chemical industries.
Brotica
Bellvue
www.interval33.com
Produces Interval33, a termite attractant
which works by producing the precise
level of CO2 that has been shown to attract
termites, all natural and animal safe.
CaP Biotechnology
Golden
www.capbio.com
Develops advanced calcium phosphate
materials and devices for biomedical and
biotechnological applications.
Cargill Research
Fort Collins
www.cargill.com
Develops, processes and markets sciencebased, health promoting ingredients for
food and dietary supplement industries
worldwide.
CaridianBCT Biotechnologies, LLC
Lakewood
www.caridianbct.com
Develops techniques to improve safety of
the blood supply by reducing the pathogens
found in donated blood.
Catalent Pharma Solutions, Inc.
Boulder
www.catalent.com
specialized medical products for fluid
management of pleural effusion and ascites.
Contract pathology and pharmacology
research company that specializes in
inflammatory disease models with emphasis
on models of arthritis.
2010/2011
BIOSCIENCE COLORADO
Caveo Therapeutics
Aurora
www.caveotherapeutics.com
Cévan International, Inc.
Longmont
www.cevan.com
Colorado Genetics, Inc.
Loveland
www.coloradogenetics.com
Discovers and develops innovative
biopharmaceuticals to treat and cure
hematologic conditions. Provides
two research reagents, highly specific
monoclonal antibodies to the Mer receptor
tyrosine kinase
Delivers vitamins, minerals and botanical
extracts as well as specialty nutriceutical
formulations and antioxidants.
Provides livestock embryo-transfer
research, artificial insemination, embryo
collection, freezing and transfer, and
international import and export services.
CBL Biopharma LLC (Chemical and
Biopharmaceutical Laboratories)
Boulder
www.cblbiopharma.com
Offering peptide starting materials,
peptide intermediates, and industrial
and commercial-scale manufacturing of
proprietary and generic GMP and nonGMP peptides.
Cedarburg Hauser
Denver
www.cedarburghauser.com
Developed, scaled and optimized hundreds
of natural product extraction, isolation and
purification procedures, starting from preclinical stages to commercial production.
Manufactures blended reagents, HPLC
mobile phases, standards, buffers and
dissolution media.
Chemizon Inc.
Longmont
www.chemizon.com
Our team brings considerable experience to
a wide range of therapeutic areas including
oncology, inflammation, cardiovascular,
CNS, anti infective and metabolic diseases.
Our goal is to accelerate our collaborator’s
drug discovery efforts using a vertically
integrated discovery platform that
includes Progenitors Leadz ADMET and
radiolabeling capabilities.
Cinpathogen, Inc.
Boulder
www.cinpathogen.com
Cedus
Fort Collins
www.cedusinc.com
Dedicated to the research, development
and commercialization of hormonal based
health care strategies for both the human
and companion animal markets including
technology for sterilizing companion
animals with a single injection.
Develops novel radiopharmaceutical
imaging agents, radiotherapeutic agents
and local regional radio/chemotherapeutic
drug delivery systems for the diagnosis,
treatment and post therapy asessment of
cancer, cardiovascular disease, infectious
disease and metabolic diseases.
Ceragenix Pharmaceuticals, Inc.
Denver
www.ceragenix.com
Engages in the discovery, development
and commercialization of a portfolio of
innovative products for dermatolog and
infectious disease applications.
2010/2011
Brings together clinical operations,
diagnostic laboratories and access to a
large tissue bank to support diagnosis and
conduct protocol-driven research on the
etiology, pathogenesis and treatment of
disease.
ClinImmune Labs
Aurora
www.clinimmune.com
Cell>Point
Centennial
www.cellpointweb.com
BIOSCIENCE COLORADO
CHATA Biosystems
Fort Collins
www.chatasolutions.com
Provides clinical HLA typing and cross
matching in support of kidney, bone
marrow, heart, lung and pancreas transplant
programs.
Clovis Oncology, Inc.
Boulder
www.clovisoncology.com
Clovis Oncology is a biopharmaceutical
company focused on acquiring, developing
and commercializing innovative anti-cancer
agents in the US, Europe and additional international markets. Building on its core competencies in clinical development, regulatory
affairs and commercialization of innovative
anti-cancer agents, Clovis intends to license or
acquire rights to concology compounds in all
stages of clinical development.
Colorado Histo-Prep (CH-P)
Fort Collins
www.histoprep.com
Produces high quality slides, clinical
chemistry and hematology data and fully
integrated and detailed seamless pathology
reports.
Colorado Serum Company
Denver
www.colorado-serum.com
Supplies veterinary biologic vaccines,
instruments, laboratory reagents and
serums for the veterinary industry.
Cytomation GTX, Inc.
Fort Collins
www.cytomationgtx.com
Develops a sensitive and rapid genotoxicity
assay in mammalian cells using flow
cytometry.
Cytoskeleton, Inc.
Denver
www.cytoskeleton.com
Offers kits for drug screening, signal
transduction and cytoskeletal research
specializing in the production of purified
proteins and easy-to-use kits to study
biochemical and cellular processes.
DaVita
Lakewood
www.davita.com
DaVita provides a complete range of
dialysis treatments and support services for
patients living with chronic kidney failure.
DMI BioSciences, Inc.
Aurora
www.dmibio.com
Discovers and develops therapeutic options
to treat men’s health, ophthalmology, and
oncology with earlier-stage NCE programs
in autoimmune, cardiovascular and
oncology.
53
Eckstein Diagnostics
Fort Collins
970-223-3203
Genentech
Denver
www.gene.com
Greffex, Inc.
Aurora
www.greffex.com
Developing techniques to directly and
indirectly detect pathogens from tissues and
fluids through various methods.
Using human genetic information to
discover, develop, manufacture and
commercialize medicines to treat patients
with serious or life-threatening medical
conditions.
Develops and produces new therapeutics
for immune suppression in humans to
prevent transplant rejection, improve gene
therapy and develop novel approaches to
the treatment of autoimmune diseases.
Genesis Laboratories, Inc.
Wellington
www.genesislabs.com
Hauser Laboratories, Division of
Microbac
Boulder
www.hauserlabs.com
Efficas, Inc.
Boulder
www.efficas.com
Develops bioactive products that offer
natural relief from asthma and allergies in
both humans and animals.
ELISA Tech
Aurora
www.elisatech.com
Provides immunoassays for the
measurement of cytokines, growth factors,
and lipid inflammatory mediators such as
prostaglandins and leukotrienes
Provides services to clients in the agrochemical and pharmaceutical industries,
rodenticide research and development, as
well as invasive species, zoonotic disease,
and conservation research.
Provides research, development, and testing
to the pharmaceutical, natural products,
dietary supplement, and medical device
industries.
GeneThera, Inc.
Arvada
www.genethera.net
HemoGenix®
Colorado Springs
www.hemogenix.com
Identifies genes with a high likelihood
of commercial value for downstream
validation through their proprietary
Adapted Traits platform.
Develops and markets the latest molecular
technologies to eradicate “cross over”
diseases such as Johne’s Disease, Mad Cow
Disease, Chronic Wasting Disease, and
E.coli. Develops assay tests and vaccines
to radicate the threat to humans of diseases
transmitted up the food chain by cattle, elk
and deer.
Private contract research service and
assay development laboratory specializing
in developing predictive in vitro assay
platforms for primary human and animal
target cells and stem cell hemotoxicity
testing.
Feiger Health Research Center (FHRC)
Wheatridge
www.feigerresearch.com
Genetic Technologies Limited
Fort Collins
www.gtglabs.com
Private research facility specifically focused
on clinical trials for medication to treat
depression.
Uses the latest technology to identify
changes in DNA to either confirm a
diagnosis of a specific disorder of which a
person displays signs or symptoms, or to
identify individuals at risk of developing a
disease before any symptoms appear.
Designed test parameters using continuous
variables that may be correlated to clinical
features or may be followed over time to
measure disease progression. HepQuant-E
is non-invasive, uses stable (not radioactive)
isotopes, and relies on natural, well-defined
hepatic functions to measure the portal
circulation.
FluTrends creates an anti-viral nose and
throat spray to combat influenza, including
the H1N1 swine flu.
GlaxoSmithKline
Denver
www.gsk.com
Heska Corporation
Loveland
www.heska.com
GEL Analytics, LLC
Golden
www.gel.com
Produces medicines that treat six major
disease areas – asthma, virus control,
infections, mental health, diabetes and
digestive conditions as well as vaccines and
new treatments for cancer.
Develops advanced diagnostics and
specialty products for veterinary practices
that focus on companion animals.
Evolutionary Genomics (EG)
Lafayette
www.evolgen.com
FluTrends International, LLC
Denver
www.flutrends.com
Offers expertise in the field of mass spectrometry and provides chemistry, radiochemistry,
radiobioassay and bioanalytical analysis.
Gene Check, Inc.
Greeley
www.genecheck.com
Develops, produces and markets reagents
and kits for research and offers veterinary
genotyping tests for sheep.
54
GlobeImmune, Inc.
Louisville
www.globeimmune.com
Discovers, develops and manufactures
potent, targeted molecular immunotherapies
called Tarmogens, targeted antigens that
distinguish diseased cells from normal
cells, for the treatment of cancer and
HepQuant, LLC
Aurora
www.hepquant.com
Hiberna Corporation
Boulder
www.hibernapharma.com
Pursuing the potential clinical application
of hibernation in order to slow metabolism
thereby extending survival limits in traumas
that reduce oxygen to certain cells, e.g. in
the heart and brain.
2010/2011
BIOSCIENCE COLORADO
High Quality Research, LLC (HQR)
Fort Collins
www.hqrllc.com
iPDx Biosciences, Inc.
Boulder
www.ipdxbio.com
KromaTid, Inc.
Fort Collins
www.kromatid.com
Provides contract research in a wide range
of in vivo studies utilizing several different
animal models.
Develops and markets multiplexed immunoassay and proteomic test systems
and applications for the decentralized
and point-of-care personalized diagnostic
market. Clinical applications will focus
on autoimmune, metabolic, oncology and
neurodegenerative disorders.
Develops a method and kit using chromatid
paints to improve detection of chromosomal
inversions. The improvement is important
to medical applications such as cancer and
birth defects.
Hospira, Inc.
Boulder
www.hospira.com
Supplies injectably generic and specialty
pharmaceuticals. The Colorado site
specializes in the supply of active
pharmaceutical ingredients for both internal
and external markets.
IHCtech, LLC
Aurora
www.ihctech.net
Offers custom histopathology services,
antibodies, probes and biosensors
tested in tissue. Specializes in
immunohistochemistry and in situ
hybridization.
imuTek Laboratories, Inc.
Fort Collins
www.imutek.com
Develops and markets bovine colostrums
for the nutrition and health products
industry. The first manufacturer to receive
an indication for colostrum for the passive
transfer of antibodies (immunoglobulins) in
dry powder form.
InB: Paxis Pharmaceuticals, Inc.
Boulder
www.paxispharma.com
Manufactures and markets the generic
active pharmaceutical ingredient (API)
Paclitaxel as well as other naturally derived
taxanes.
Institute for Therapeutic Biology
Denver
www.therapeuticbiology.org
Research organization studying the Role of
T-Cell maturation in Immunology.
Develops therapies for organ transplantation
and genetic disease with products based on
the veto effect which occurs when specific
T-cells programmed to destroy a transplant
are all permanently inhibited.
Develops vaccines for emerging infectious
diseases worldwide, including dengue
fever, west nile, plague, smallpox and avian
influenza.
2010/2011
Regulated Testing
down to a science
www.labs-inc.org
Technical Sales Team 720.528.4799
Toll Free 800.321.6088
Johnson & Johnson/Ortho Biotech
Denver
www.jnj.com
LABS, Inc.
Denver
www.labs-inc.org
Manufactures a broad selection of health
care products, as well as a provider
of related services, for the consumer,
pharmaceutical, and medical devices and
diagnostics markets.
Provides laboratory testing services focused
on donor eligibiligy determination and
final product safety; infectious disease,
microbiology, histocompatibility and
environmental monitoring.
Keen Ingredients, Inc.
Louisville
www.keeningredients.com
Legacy BioDesign, LLC
Johnstown
www.LegacyBioDesign.com
Develops process to de-bitter and stabilize
quinoa naturally. Supplying the natural and
gluten free industries with high quality
Quinoa ingredients.
Conducts peptide and protein formulation
and assay development work for biopharma
companies. The company also specializes in
drug delivery and process development of
biotechnology-based products.
Keeton Industries, Inc.
Wellington
www.keetonaqua.com
Researches and develops biological water
treatment, aeration, ozone aeration, solids
removal, biofiltration and other new
technologies.
Kimball Genetics, Inc.
Denver
www.kimballgenetics.com
Genetic testing laboratory specializing in
DNA analysis for common genetic disorders that are preventable or can be treated.
InViragen, Inc.
Fort Collins
www.inviragen.com
BIOSCIENCE COLORADO
Isogenis, Inc.
Aurora
www.isogenis.com
Lohocla Research Corporation
Aurora
www.lohocla.com
Develops diagnostics and therapeutics
focused on pain, psychiatric and addictive
disorders such as alcoholism, depression,
smoking cessation and chronic pain.
MacLeod Pharmaceuticals, Inc.
Fort Collins
www.macleodpharma.com
Develops and manufactures anti-bacterial
pharmaceuticals for the veterinary industry.
Mantic Biotech
Loveland
www.manticbiotech.com
Develops proprietary technology and software to accurately represent and model protein conformations as discrete structures.
55
Martek Biosciences Boulder
Corporation
Boulder
www.martek.com
Develops, manufactures and sells
products from microalgae. Products
include nutritional supplements and food
ingredients which play a role in promoting
mental and cardiovascular health.
MBC Pharma, Inc.
Aurora
www.mbcpharma.com
Biopharmaceutical company focused on
discovering and developing drugs for bone
diseases such as cancer and osteoporosis.
MedImmune, LLC
Denver
www.medimmune.com
Strives to provide better medicines
to patients, new medical options for
physicians, and rewarding careers to
employees.
Molecular BioSciences, Inc.
Boulder
www.molbio.com
Manufactures products such as water soluble
biotinylation reagents, vitamin derivatives,
crosslinking reagents, lipophilic probes,
fluorophores, radioiodination reagents, and
dendritic cores for preparing oligomers.
Monsanto Company
Boulder, Denver, Lakewood
www.monsanto.com
Develops technology to produce healthier
foods, better animal feeds and more fiber,
while reducing agriculture’s impact on our
environment. Products lines include seeds
and traits and agricultural productivity.
MycoLogics, Inc.
Aurora
www.mycologics.com
Novartis Pharmaceuticals
Corporation
Broomfield
www.novartis.com
Researches and develops products to
protect and improve health and well-being
with core businesses in pharmaceuticals,
vaccines, consumer health, generics, eye
care and animal health.
Novus Biologicals, Inc.
Littleton
www.novusbio.com
Develops, tests and markets antibodies for
research of human diseases such as cancer,
cardiovascular and neurological disorders.
Nutraceutix, Inc.
Lafayette
www.nutraceutix.net
Specializes in the development of
therapeutic and prophylactic vaccines
against fungal and parasitic pathogens.
Offers probiotic organisms (powders) and
finished probiotic supplements. Specializes
in custom crafting dietary supplements with
advanced delivery technologies.
Mediral International, Inc.
Denver
www.mediral.com
Mycos Research, LLC
Loveland
www.mycosresearch.com
Oberon FMR
Idaho Springs
www.oberonfmr.com
Develops, manufactures and sells
homeopathic pharmaceuticals taking into
consideration antidotes.
Provides mycobacterial derived
biochemicals to the research community,
contract research, models for tuberculosis
research, and other BSL3 organisms, and
novel monitoring or vaccine products in the
area of mycobacterial infection.
Researches and develops the production of
single cell protein (SCP) from un-utilized
food processing by-product streams.
Supplier of high-quality SCP destined for
use in animal feed diets.
Merck & Co., Inc.
Denver
www.merck.com
Merck and Co. produces products that
cover a broad range of areas, including
heart and respiratory health, infectious
diseases, sun care and women’s health. And
they focus their research on conditions that
affect millions of people around the world
– diseases like Alzheimer’s, diabetes and
cancer – while building strengths in new
areas like biologics.
N30 Pharmaceuticals, LLC
Boulder
www.n30pharma.com
miRagen Therapeutics
Boulder
www.miragentherapeutics.com
Improves patients’ lives by developing
innovative microRNA (miRNA)
based therapeutics for the treatment
of cardiovascular and muscle disease.
miRNAs, are a recently discovered class of
small RNAs encoded in the genome, are
short, single-stranded RNA molecules.
56
Omni Bio Pharmaceutical, Inc.
Greenwood Village
www.omnibiopharma.com
A clinical stage biopharmaceutical
company focused on modulating
s-nitrosothiols to treat respiratory diseases.
Advancing broad-spectrum therapeutics
targeting bacterial and viral diseases,
biohazards, diabetes and transplant
rejection.
Nanodisc, Inc.
Boulder
www.nanodiscinc.com
OmniaVincit, LLC
Denver
www.omniavincit.com
Develops and commercializes Nanodiscs
that permit the functional solubilization of
membrane-associated proteins (MAPs) as
both drug targets and as drugs themselves.
Efficiently delivers successful clinical
development programs and clinical trials
in the Sponsor/Client - Contract Research
Organization (CRO) environment. The
OV Co-Founders/Principals have created
an organization that is flexible, nimble,
responsive, creative, and direct.
Nex Step, Inc.
Santa Fe, NM
505-501-2038
Pharma cogenomic decision support
software development for drug-genenutrient interactions.
2010/2011
BIOSCIENCE COLORADO
Optibrand Ltd., LLC
Fort Collins
www.optibrand.com
Pfizer Pharmaceutical Company
Centennial
www.pfizer.com
Qgenta
Aurora
720-859-4045
Provides a fraud-resistant system to positively
identify animals from birth and throughout
the food processing chain. The Secure Identity
Preservation system helps assure food safety
and control the spread of animal disease.
Discovers, develops, manufactures, and
markets prescription medicines for humans
and animals.
Harnessing innovative chemistry and
biology in the development of molecular
targeted agents for the treatment of cancer.
PhosphoSolutions®
Aurora
www.phosphosolutions.com
Quark Pharmaceuticals, Inc.
Boulder
www.quarkpharma.com
Designs and produces phosphoproteins
solutions using phosphor-specific
antibodies. Phosphoproteins are thought to
be critical elements in neurological diseases
such as Alzheimer’s and in cancer.
Discovers and develops siRNA drug
candidates for treating Age-related Macular
Degeneration and prevention of Acute
Renal Failure.
OPX Bioechnologies
Boulder
www.opxbiotechnologies.com
Technology platform enables rapid, rational,
and robust optimization of microbes and
bioprocesses to manufacture bioproducts
with equivalent performance and improved
sustainability at lower cost compared to
petroleum-based alternatives.
OSI Pharmaceuticals
Boulder
www.osip.com
Pisces Molecular
Boulder
www.pisces-molecular.com
Applies molecular biology to problems in
the aquatic environment.
Develops and commercializes high-quality
and novel pharmaceutical products for
patients with cancer, diabetes, and obesity.
Premier Laboratory, LLC
Boulder
www.premierlab.com
Pambec Laboratories, Inc.
Loveland
[email protected]
Contract research laboratory that offers
both standardized and specialized
preclinical pharmacology, histology and
pathology services.
Researches drug discoveries in the field of
AIDS.
Paragon Analytics
Fort Collins
www.paragonlabs.com
Environmental and radiochemistry testing
laboratory offering radiochemistry, mixed
waste, explosives, organics, metals, and
general chemistry analyses. Division of
DataChem Laboratories, Inc.
Proteome Resources
Englewood
www.proteomeresources.com
Manufactures ubiquitin-proteasome
enzymes and proteins and offers antibodies,
and custom protein and peptide services.
Provident Pharmaceuticals, LLC
Colorado Springs
www.providentpharma.com
Peak Analytical, Inc.
Golden
www.peaklab.net
Provides product development,
manufacturing and packaging, and
laboratory services for the pharmaceutical
industry.
Specializes in materials and chemical
analysis. Performs a variety of molecular
and atomic level spectroscopic techniques
to identify failures and defects.
Pulmonex, Inc.
Boulder
www.pulmonexinc.com
Developing a therapeutic product for
tuberculosis.
Peak BioSciences Inc.
Fort Collins
www.peakbiosciences.com
Specializes in developing and
commercializing nanoscale (ultra-localized)
radiotherapy products to treat cancer.
NanoZome is the first and only radiosurgery
that uses extremely small radiation spots to
kill cancer cells.
BIOSCIENCE COLORADO
2010/2011
Pyxant Labs, Inc.
Colorado Springs
www.pyxant.com
Specializes in GLP bioanalytical chemistry
development support for life sciences
clients.
Quasar Medical Co., LLC
Golden
www.quasargroup.com
Focus is on the development of high-value,
niche market, diagnostic and therapeutic
medical products that can be manufactured
and marketed more cost effectively by the
Quasar Group than by huge multi-national
pharmaceutical companies.
Reckitt Benckiser (RB)
Denver
www.rb.com
Fastest-growing companies in household,
health and personal care products.
Regenerative Sciences Inc.
Broomfield
www.regenexx.com
Advances stem cell therapies through
development of Regenexx™, an injection
procedure to treat a wide variety of painful
conditions.
Roche Colorado
Boulder
www.rochecolorado.com
Develops manufacturing processes for
complex pharmaceutical compounds in
the Colorado manufacturing facility, a
resource for small to large-scale peptide
manufacturing.
Rocky Mountain Diagnostics, Inc.
Colorado Springs
www.rmdiagnostics.com
Provides immunodiagnostic assays and
reagents for biogenic amines, research
reagents, a CLIA certified reference
laboratory and contract manufacturing
services.
57
Rocky Mountain Instrumental
Laboratories
Fort Collins
www.rockylab.com
Provides contract chromatographic
and mass spectrometric analysis of
pharmaceuticals (both traditional drugs
and biotechnology products, such as
proteins and peptides and oligonucleotides),
veterinary and human endocrinology, and
forensic toxicology.
Rocky Mountain Reagents, Inc.
Golden
www.rmreagents.com
Manufactures stains, culture media and
chemistry solutions for the medical
industry, as well as titration reagents,
indicators, acids, bases, and a variety of
chemicals for industrial uses.
Sandoz
Broomfield
www.us.sandoz.com
Focuses on pharmaceuticals, consumer
health, generics, eye care and animal
health. Therapeutic categories
inlcude anti-infectives, anti-arthritics,
cardiovasculars, gastrointestinal agents &
psychotherapeutics.
Sentry Biosciences
Englewood
720-488-4725
Discovers and develops compounds that
regulate the process pf programmed cell
death (apoptosis).
Sharklet Technologies, Inc.
Centennial
www.sharklet.com
Engineers surface technologies (Sharklet™)
that controls the growth of dangerous
bacteria.
STA Laboratories, Inc.
Longmont
www.stalabs.com
Agricultural product testing laboratory that
offers seed quality, genomics, plant health
and diagnostic services and products.
Summit Plant Laboratories, Inc.
Fort Collins
www.plantlabs.com
V-Clip Pharmaceuticals, Inc.
Colorado Springs
www.viralgenetics.com
Applies laboratory plant cloning and
greenhouse technologies to produce
planting stocks for breeders, greenhouses,
and field crop producers.
Modulating the immune system up or down,
and to causing a process called apoptosis.
This is accomplished using small protein
fragments (called peptides) to displace
other “bad” peptides that have been picked
up by immune system cells. These so-called
bad peptides sometimes result from the
body’s natural attempts to fight off viruses,
bacteria, and various diseases, including
HIV/AIDS.
Taiga Biotechnologies, Inc.
Aurora
www.taigabiotech.com
Develops cellular, biologic and
small molecule approaches to treat
hematological diseases, including cancers,
immunodeficiencies and autoimmune
conditions.
Taligen Therapeutics, Inc.
Aurora
www.taligentherapeutics.com
Develops a protein expression technology
platform called ExpressTec with a
product pipeline in human nutrition and
therapeutics.
Focuses on the treatment of serious
inflammatory diseases including asthma,
macular degeneration and immune kidney
disease.
Ventrus Biosciences, Inc.
Greenwood Village
www.ventrusbio.com
ThermoFisher Scientific
Lafayette
www.thermofisher.com
A specialty pharmaceutical company
focused on the late-stage development and
commercialization of gastroenterology
products.
Working to bring you the highest quality
brands and products available, including
electrophoresis and protein labeling
products from Amersham, illustra™
purification kits and a full line of Affinity
Chromatography products.
TOLMAR, Inc.
Fort Collins
www.tolmar.com
Develops and manufacturers both
proprietary and generic pharmaceutical
products with specific focus in therapeutic
areas of dental, dermatology, and oncology.
Upsher-Smith Laboratoriess, Inc.
Denver
www.upsher-smith.com
Develops, manufactures and markets a vast
range of prescription and over-the-counter
products for cardiology, dermatology,
women’s health and other areas.
US Pharmacal Company, Inc.
Erie
www.uspharmacal.com
Researches, develops and sells topical
pharmaceuticals for the senior community.
58
Ventria Bioscience
Fort Collins
www.ventria.com
Verdant BioSciences Corporation
Denver
www.verdantbio.com
Develops plant biochemical regulators
that provide superior plant performance
and unlock the productive power of plants
in markets from floriculture to industrial
agriculture.
Vitro Diagnostics, Inc.
Golden
www.vitrodiag.com
Develops and commercializes products
derived from human cell line research with
a focus predominantly in stem cell R&D
related to numerous diseases such as heart
disease, stroke, Parkinson’s and Alzheimer’s
disease.
Vitrolife, Inc.
Englewood
www.vitrolife.com
Develops, manufactures and sells products
and systems for the preparation, cultivation
and storage of human cells, tissue and
organs. Product areas include fertility,
transplantation and stem cell cultivation.
2010/2011
BIOSCIENCE COLORADO
Warren Analytical Laboratory
Greeley
www.warrenlab.com
Specializes in food microbiology,
molecular biology, food chemistry,
residue chemistry and nutritional
labeling.
Western States Biopharmaceuticals,
Inc.
Aurora
www.westernstatesbiopharm.com
Discovered a way to block the destructive
effects of these diseases like Rheumatoid
Arthritis without affecting the immune
system’s natural ability to fight disease.
Wildlife Pharmaceuticals, Inc.
Fort Collins
www.wildpharm.com
Providing pharmaceuticals for the safe
and humane care of non-domestic and
exotic wildlife species.
Windom Peak Pharmaceuticals
Boulder
www.windompeak.com
Develops novel antibiotics to treat
YewSavin, Inc.
Fort Collins
www.ajorganica.com
Develops chemical and biochemical
technologies. Successfully finished
multi-step syntheses using Bromination,
Grignard reaction, Suzuki coupling,
Amidation, and Esterification reactions.
ZeoponiX, Inc.
Boulder
www.zeoponix.com
Develops NASA originated technology
to produce a soil amendment/fertilizer
zeoponic material that utilizes nutrients
more efficiently and reduces nutrient
leaching into the environment.
ZooPharm, Inc.
Fort Collins
www.zoopharm.net
Specialized veterinary compounding
pharmacy. We custom compound
analgesics, sedatives, their antagonists,
and other unique drugs for use in
veterinary medicine.
BIOSCIENCE COLORADO
2010/2011
BIOFUELS AND RELATED COMPANIES
A1 Organics
Eaton
www.a1organics.com
Composts and recycles organic by-products
from various waste: yard trimmings, wood,
biocides, agricultural by-products, manure,
brewery by-products, construction debris
and food residuals.
A2BE Carbon Capture, LLC (algae@
work)
Boulder
www.algaeatwork.com
developing bio-secure, scalable, climate
adaptive, and highly cost effective
technology for producing valuable fuel and
food from CO2 using algal photosynthesis
and bio-harvesting.
Aerophase, Inc.
Longmont
www.aerophase.com
Research and Development of technologies
that reduce environmental impact, and
efficient extraction system for biodiesel
Agro Management Group, Inc.
Colorado Springs
www.agromgt.com
Researches, develops and markets vegetable
based motor oil for use in 4 cycle engines.
BBI International
Lakewood
www.bbibiofuels.com
Offers consulting services, including
feasibility studies, market analyses,
site & resource assessments, economic
impact studies, business plans, industry
benchmarking and industry surveys to the
biofuels sector.
BioEnergy of Colorado, LLC
Denver
www.bioenergycolorado.com
Biomass Energy Foundation (BEF)
Franktown
www.woodgas.com
Researches alternative fuels such as dried
fruit pits, vegetable oil, wood, coffee
grounds and the methods to produce
biofuels.
Blue Sun Biodiesel
Golden
www.gobluesun.com
Distributes premium agricultural and
renewable fuel products. Blue Sun Fusion™
a blend of premium Blue Sun Biodiesel
(20%) with petroleum diesel fuel (80%),
along with proprietary additive package
specifically tailored for regional climates
and seasons, is available at numerous retail
pumps throughout Colorado, Wyoming,
New Mexico, Nebraska, Utah, and Idaho.
Center for Biorefining and Biofuels
(C2B2)
Boulder
www.c2b2web.org
A cooperative research and educational
center devoted to the conversion of biomass
to fuels and other products. Works to
establish ground-breaking research and
educational programs for the advancement
of renewable energy technologies.
CH2M Hill
Englewood
www.ch2m.com
One of the world’s leading firms in the
design of biochemical and biofuels
facilities. Provides engineering,
procurement, construction, management,
consulting and sustaining services for
biochemicals, ethanol, cellulosic ethanol,
and biodiesel plants.
Ciris Energy, Inc.
Centennial
www.cirisenergy.com
Produces biofuel alternatives utilizing
Soy Biodiesel from virgin soy oil. Current
product line includes Biodiesel (Gold and
Green™) and BioHeat.
Formed to develop, commercialize and
produce clean energy from abundant, lowvalue carbon sources, on a large scale. We
are practical technology implementers, and
primarily an energy production company.
BioFuel Energy Corporation
Denver
www.bfenergy.com
Community Power Corporation
Littleton
www.gocpc.com
Constructs large scale ethanol production
facilities in cooperation with Cargill and
owns and operates two of the largest dry
mill ethanol facilities in the United States.
Develops, commercializes and markets
modular biopower systems to meet the
needs of distributed energy consumers in
both developing and developed countries.
59
Copernican Energy, Inc.
Boulder
www.copernicanenergy.com
Merrick® & Company
Aurora, Colorado Springs
www.merrick.com
Solix Biofuels, Inc.
Fort Collins
www.solixbiofuels.com
Produces fuels and chemicals from
renewable feedstocks through the
application of solar-thermal energy.
Provides engineering, construction
management, and development services
for biomass conversion-to-ethanol projects,
also providing consulting services to oil and
gas clients and local regulated utilities.
Develops massively scaleable photobioreactors for the production of biodiesel
and other valuable bio-commodities from
algae oil.
Delta Dynamics, LLC
Denver
www.deltadynamicsenergy.com
Constructs and installs small-scale biomass
plants.
Front Range Energy, LLC
Windsor
www.frontrangeenergy.com
Ethanol producer since 2006. Will process
approx. 40 million gallons of ethanol and
396,000 tons of wet distillers’ grain annually.
GeoSynFuels, LLC
Golden
www.geosynfuels.com
Developsd a low-cost method to convert
cellulosic biomass into fuel. The technology
uses biological mechanisms set in a solidstate fermenter (“SSF”) to convert the
biomass into ethanol and/or methane.
Gevo, Inc.
Englewood
www.gevo.com
Develops advanced biofuels like isobutanol,
butanol that will provide a sustainable path
to the replacement of petrochemicals like
gasoline, diesel and jet fuel.
Great Western Ethanol
Greeley
www.greatwesternethanol.com
Produces Ethanol/DDGS/CO2.
Intermountain CHP Center
Boulder
www.intermountainCHP.org
Formed by the U.S. Department of Energy
to increase adoption of Combined heat and
power (CHP) in the states of Arizona, Colorado, New Mexico, Utah, and Wyoming.
LUCA Technologies, Inc.
Golden
www.lucatechnologies.com
Researches the ability of naturally
occurring microorganisms to convert underutilized domestic oil, organic-rich shale and
coal resources to clean, renewable energy.
OPX Biotechnologies, Inc.
Boulder
www.opxbiotechnologies.com
Applying our EDGE™ (Efficiency Directed
Genome Engineering) technology, we will
manufacture bio-based products that are
more economical and sustainable than
petroleum-based alternatives.
PolyNEW, Inc.
Golden
www.polynewinc.com
Developed a new class of PLA bioplastics
which it terms “ecobionanocomposites.”
These are nanocomposites from 100%
renewable resources that could be used in
a wide variety of applications including
medical device applications.
Power Ecalene Fuels, Inc.
Arvada
http://powerecalene.com
Exclusive licensor of a patented nano-catalyst
technology that efficiently converts “syngas”
or “producer gas” into a premium mixed
alcohol transportation fuel called Ecalene™.
Ecalene™ is usable as a stand-alone fuel for
cars, trucks, buses, jet aircraft and boats.
PureVision Technology, Inc.
Fort Lupton
www.purevisiontechnology.com
Develops a carbon-neutral biomass
fractionation technology that converts
cellulosic biomass into sugars, energy
and fiber that are bio-based raw materials
to make many industrial and consumer
products.
Range Fuels
Broomfield
www.rangefuels.com
Converts biomass that cannot be used for
food into low carbon biofuels and clean
renewable energy using emerging clean
energy technologies. Biomass includes
all plant and plant-derived material, such
as wood, switch grass, corn stover, and
miscanthus grass – making it a renewable
energy resource that produces no net
greenhouse gases.
Sterling Ethanol, LLC
Sterling
www.sterlingethanol.com
Produces 42 million gallons of ethanol
annually, using the distiller’s grain produced
as a co-product of ethanol to the areas cattle
feeders for its high protein levels.
Sundrop Fuels, Inc.
Louisville
www.sundropfuels.com
A solar gasification-based renewable energy
company.
ZeaChem
Lakewood
www.zeachem.com
Developed a cellulose-based biorefinery
platform capable of producing thirdgeneration ethanol fuel and intermediate
chemicals. Our indirect approach leapfrogs
the yield and carbon dioxide (CO2)
problems associated with traditional and
cellulosic based ethanol processes.
RESEARCH AND EDUCATION
Advanced Diagnostic Laboratories
(Adx) at National Jewish Medical and
Research Center
Denver
www.njlabs.org
Adx offers cost-effective and timely preclinical, clinical and non-clinical trials and
helps customers select, customize, perform,
interpret and report clinical tests. Their
reference laboratory provides solutions for
the rapid development of custom assays,
consultation, clinical strategy assessments
and innovation within the areas of the
National Jewish expertise. ADx operates
under GLP guidelines when applicable and
the laboratories are fully accredited by the
College of American Pathologists (CAP)
and the Clinical Laboratory Improvement
Act (CLIA), as well as others.
Aims Community College
Greeley, Loveland, Fort Lupton
www.aims.edu
One of the largest and most comprehensive
two-year colleges in Colorado, offering
more than 160 degree and certificate
60
2010/2011
BIOSCIENCE COLORADO
programs. Since 1967 Aims has established
four campuses, constructed 18 buildings,
expanded curriculum to 2,000 day, evening
and weekend courses and taught more than
300,000 students.
AMC Cancer Research Center
Denver
www.amc.org
Biological Sciences Curriculum Study
(BSCS)
Colorado Springs
www.bscs.org
A nonprofit corporation that endeavors
to improve all students’ understanding
of science and technology by developing
exemplary curricular materials, supporting
their widespread and effective use,
providing professional development, and
conducting research and evaluation studies.
Bonfils Blood Center
Denver
www.bonfils.org
One of the nation’s leading community
blood centers through their commitment to
quality service, innovation, research and
technology. They offer a full range of blood
products and services to healthcare partners
including supplying rare blood units or
helping to determine the best cross-matched
unit to endure the best possible patient
outcomes.
Centers for Disease Control and
Prevention/Division of Vector-Borne
Infectious Disease
Fort Collins
www.cdc.gov/ncidod/dvbid
The Division of Vector-Borne Infectious
Diseases (DVBID) is part of the U.S. Centers
for Disease Control and Prevention (CDC).
CDC is the lead federal agency for protecting the health and safety of people at home
and abroad. DVBID serves as a national and
international reference center for vectorborne viral and bacterial diseases, such
as West Nile virus, Lyme disease, plague,
tularemia, yellow fever and dengue. It coordinates national disease monitoring activities, conducts field and laboratory research,
responds to epidemic situations, develops
strategies for disease prevention and control,
provides diagnostic reference and epidemio2010/2011
Colorado Prevention Center
Denver
www.cpcmed.org
Revolutionizing clinical research and creating innovative preventative programs that
will change behavior to improve your health.
AMC is a national, not for profit research
institute dedicated to the prevention
and control of cancer and other chronic
diseases. AMC is conducting innovative
and important research in the areas of
cancer causation and prevention, behavioral
research, nutrition, clinical and community
studies and health communication.
BIOSCIENCE COLORADO
logic consultation, and conducts technical assistance and professional training activities.
Colorado School of Mines
Golden
www.mines.edu
A public research university internationally
recognized for its leadership in engineering,
applied science and related disciplines,
with a special emphasis on the Earth
and its resources. These programs, with
strong interdisciplinary linkages across
the campus, have led to the integration
of bioscience and biotechnology into
educational and scholarly activities. CSM
has created a Bioengineering and Life
Science Program that draws upon faculty
and students from all of the academic units.
Biostatistical
Consulting Service
Comprehensive statistical support in the
design, conduct and analysis of research
studies in basic science, clinical and
epidemiologic research
Study Planning
Data Analysis
Data Management Reporting
Contact: Jens Eickhoff, PhD
(970)-491-5268
[email protected]
www.stat.colostate.edu/consulting/
Colorado State University
Fort Collins, Pueblo
www.colostate.edu
As one of the nation’s leading research
universities, Colorado State University
is committed to realizing its vision as a
21st century land-grant university. CSU
leads the world in such areas as infectious
disease research, atmospheric science and
environmental science. Its faculty members
are tackling such issues as the reemergence
of tuberculosis, the brown cloud of air
pollution in Asian cities, severe weather
forecasting, nutrition and wellness, and
bioterrorism. In addition to its excellent
programs in those areas, CSU offers among
the very best professional programs in
the United States in areas like veterinary
medicine, occupational therapy, journalism,
agriculture and construction management.
Its programs in the arts, humanities and
social sciences are also outstanding.
Community College of Aurora (CCA)
Aurora
www.ccaurora.edu
CCA provides lifelong educational
opportunities, prepares the current and
future workforce, and promotes excellence
in teaching, learning and service. CCA
offers a unique Biotechnology Technician
Research and Development Certificate
designed to train highly skilled lab
personnel for the biotech industry.
Denver School of Science and
Technology (DSST)
Denver
www.scienceandtech.org
Is dedicated to providing a diverse student
body with an outstanding liberal arts
high school education with a science and
technology focus. By creating a powerful
learning community centered on core
values and a shared commitment to
academic excellence, DSST will increase
the number of underrepresented students
(women, minorities and economically
disadvantaged) who attain college science
and liberal arts degrees.
Rose Medical Center
Denver
www.rosemed.com
Has earned a reputation as Denver’s
“Baby Hospital” while becoming a leader
in comprehensive women’s services,
internal medicine, endoscopy, heart and
vascular care, orthopedics and total joint
replacement, bariatric surgery, sports
medicine and aesthetic surgery.
Front Range Community College
Brighton, Fort Collins, Longmont and
Westminster
www.frontrange.edu
Front Range Community College, Colorado’s largest community college, provides
instruction, in both general education and
occupational areas, which may lead to a
certificate, an associate degree, or transfer
to a four-year institution. The college also
provides college preparatory education,
non-credit instruction for personal and
professional development, and workplace
skill development. With campuses located
in Fort Collins, Longmont and Westminster,
the college is proud of its many partnerships to provide quality programs that are
responsive to the needs of its local communities.
61
Keystone Symposia on Molecular and
Cellular Biology
Silverthorne
www.keystonesymposia.org
A non-profit organization that serves as a
catalyst for the advancement of biomedical
and life sciences by connecting scientists
within and across disciplines at conferences
and workshops held at venues that create
an environment conducive to information
exchange, generation of new ideas, and acceleration of applications that benefit society.
National Institute of Standards and
Technology (NIST)
Boulder
www.nist.gov
NIST is a non-regulatory federal agency that
operates eight different science and advanced
technology research divisions in Colorado.
NIST’s list of research accomplishments
includes a NIST senior scientist winning the
Nobel Prize in 2001 for creating the world’s
first “Bose-Einstein condensate.” In 2003
another NIST scientist won a MacArthur
Fellowship for discovering a new quantum
gas and was named by Science as one of the
top ten scientific advances of the year.
Poudre Valley Health System
Loveland, Fort Collins
www.pvhs.org
Poudre Valley Health System operates
as a private, not-for-profit organization
providing a regional network of health
care services for the people of northern
Colorado, western Nebraska, and southern
Wyoming. The system is comprised of the
Poudre Valley Hospital, the Medical Center
of the Rockies, as well as several community clinics that provide primary and
specialized medical services. Poudre Valley
Hospital was named one of the nation’s top
100 hospitals for the fifth year, has been
considered a Magnet Nursing Practice
since 2000 and has been presented with
the American Nurses Association’s highest
award for sustained overall excellence in
nursing quality.
Regis University
Denver
www.regis.edu
The number one respiratory hospital in
the U.S., is also one of the most influential
independent biomedical research centers in
the world. More than 100 faculty members
conduct basic, translational, and clinical research in immunology, respiratory medicine,
allergy, cancer, and cell and molecular biology. NJC ranks among the top ten percent of
all institutions for NIH support and for the
impact of its research papers in the fields of
Molecular Biology, Genetics, and Biology
and Biochemistry. NJC manages a technology portfolio of more than 100 investors.
The School of Pharmacy aspires to be the
foremost school of pharmacy in the United
States where students are nurtured and
developed to become leaders in pharmacy
practice, research, education, and public
service. As a result, students graduate as
professionals who are knowledgeable,
skillful, and principled, and who are able
to make a positive impact on the dramatically changing role of pharmacists in our
transforming society. They are educated to
be committed to excellence in healthcare,
evidenced not only by their knowledge and
abilities, but also by their quality of care,
integrity, compassion, respect, advocacy,
initiative, service and leadership. To achieve
these goals, faculty members are dedicated
to providing innovative practice models,
exploring novel applications of basic and
clinical research, and illustrating the value
of lifelong learning.
National Renewable Energy
Laboratory
Golden
www.nrel.gov
Scientific Education & Research
Institute (SERI)
Thornton
www.theseri.com
National Jewish Health®
Denver
www.njc.org
The nation’s primary laboratory for renewable energy and energy efficiency research
and development (R&D). NREL’s mission
and strategy are focused on advancing the
U.S. Department of Energy’s and our nation’s
energy goals. NREL’s R&D areas of expertise
are: renewable electricity (solar, wind, biomass,
geothermal), renewable fuels (biomass,
hydrogen), integrated energy system engineering and testing (buildings, electric systems and
transportation infrastructures), and strategic
development and analysis (economic, financial,
and market analysis, planning and portfolio
prioritization).
62
SERI is a unique institute, which combines
an orthopedic clinic, specializing in spine
surgery, with a clinical research unit and
and education and training program. Our facility has available to rent an amphitheater
with full AV setup for presentations, as well
as a bioskills lab with cadaveric dissection
capabilities. We host a variety of educational programs including summer science
camps. Additionally we host a large number
of training programs sponsored by surgical
and medical companies.
Swedish Medical Center
Englewood
www.swedishhospital.com
Level I Trauma Center, serves as the
region’s referral center for neurotrauma
and is a recognized leader in the treatment
of stroke. An acute care hospital with 368
licensed beds.
United States Geological Survey
(USGS) - Center for Biological
Informatics
Denver
http://biology.usgs.gov/cbi
The Center for Biological Informatics, at
the Denver Federal Center, operates the
national Biological Information Infrastructure (NBII). This is the first comprehensive
electronic gateway dedicated exclusively
to biological science data and information
from sources throughout the world.
HELP GROW COMPANIES
FROM UNIVERSITY RESEARCH
The University of Colorado Technology
Transfer Office is seeking Front Range
businesses and professionals to volunteer as
advisors for new companies.
Contact:
Lindsay Polak
303-735-5518
[email protected]
University of Colorado
Boulder, Denver, Aurora, Colorado Springs
www.cu.edu
The University of Colorado System’s
52,000 students and 28,000 faculty and staff
contribute to every facet of life in Colorado.
The state’s economic vitality, educated
workforce, entrepreneurial climate, cultural
capital, health care delivery, and scientific
explorations all rely on the driving force of
a vigorous state university. By working with
other CU academic and research units, as
well as local, state, and federal funding agencies, commercial business, and nonprofit
organizations, CU is creating a collaborative
synergy in important areas that will better
the wellness of society. The CU Institute
of Bioenergetics, the Colorado Initiative
in Molecular Biotechnology, the Center
for Computational Biology, and the Center
for Pharmaceutical Biotechnology attract
intellectual strength to Colorado, provide
new educational opportunities, and inspire
innovative health care advances. Research
and teaching hospitals affiliated with the
University of Colorado include: The University of Colorado Hospital, The Children’s
Hospital, National Jewish Medical and
Research Center, Denver Health and the VA
Medical Center.
2010/2011
BIOSCIENCE COLORADO
University of Denver
Denver
www.du.edu
FOUNDATIONS
Strives to provide the most modern educational and research facilities in the life
sciences. Their history spans the Denver
Research Institute’s development of the
first NASA life monitoring sensors, the
establishment of a state-of-the-art forensics
laboratory, to the 2003 acquisition of the
Eleanor Roosevelt Institute with pioneering efforts in genomics and bioinformatics.
In 2004, the School of Engineering and
Computer Science unveiled Colorado’s first
undergraduate program in Bioinformatics
and a master’s degree in Bioengineering.
The interdisciplinary mission of the University enabled the Department of Biology
to launch new emphases in Bioengineering,
Biophysics and Cognitive Neuroscience
designed for molecular biology majors. In
addition to strong and quality curricula, bioengineering and life sciences at DU carry
multimillion-dollar-a-year research studies
in the creation of new knowledge and leading edge biotechnologies to improve quality
of life for a worldwide community.
University of Northern Colorado
Greeley
www.unco.edu
University of Northern Colorado (UNC) is
a multipurpose institution with a wide range
of graduate and undergraduate programs.
The university’s mission is to prepare
individuals for advanced study, professional
careers, and positions of leadership.
Work, Education and Lifelong
Learning Simulation (WELLS) Center
Aurora
[email protected]
For the first time in Colorado, one facility
offers a complete array of state-of-theart patient simulation tools for building
clinical knowledge. Even more exciting,
high-speed datacasting technology makes
this unique resource available remotely.
Students, faculty and practicing nurses and
physicians from throughout Colorado can
enhance their diagnostic and clinical skills
at the WELLS Center either on-site or
on-line.Housed in the new Bioscience East
building at Fitzsimons, the WELLS Center
represents a unique collaboration among
educators, providers and policymakers.
BIOSCIENCE COLORADO
2010/2011
Colorado State University Research
Foundation (CSURF)
Fort Collins
www.csurf.org
CSURF is a private, not-for-profit Colorado
Corporation established (in 1941) to aid and
assist the University campuses (Colorado
State University and recently Colorado
State University Pueblo) governed by the
Board of Governors of the Colorado State
University System in their research and
educational efforts. Functions include patent and licensing management; equipment
leasing and municipal lease administration; financing of equipment, real estate
and buildings through mortgage debt
obligation(s); and land acquisition, development and management.
The Children’s Hospital Foundation
Aurora
www.imaginethemiracles.org
The Children’s Hospital Foundation is the
fundraising arm for TCH programs and
operations. Since 1978, the Foundation has
raised more than $200 million for the hospital and today is in the middle of a fudnraising campaign to financially support the
building of a new hospital at Fitzsimons, as
well as Children’s programs and services.
Poudre Valley Health System
Foundation
Loveland, Fort Collins
www.foundation.pvhs.org
The Poudre Valley Health System Foundation philanthropically supports and promotes the health interests of Poudre Valley
Hospital, the Medical Center of the Rockies
and the community by raising and distributing funds for programs that target prevention, education, research, health promotion,
wellness and disease management.
University of Colorado Foundation
Boulder
www.cufund.org
The University of Colorado Foundation is
a privately governed nonprofit corporation
whose mission is to support the University
of Colorado. As a valued and trusted partner, the University of Colorado Foundation
generates the private support needed in
perpetuity for CU to achieve international
preeminence as a public research university. Our donors enable CU to reach its full
potential to transform lives world-wide
through education, research, clinical care
and community service.
Service Providers
Architecture
HOK
www.hok.com
Leo A. Daly
www.leoadaly.com
Pelsue Architecture, LLC
http://pelsuearchitecture.com
The Abo Group
www.theabogroup.com
Business Services
Anacor Compliance Services
www.anacorcompliance.com
Construction and Facilities
Apecs Inc.
www.apecs.net
BioMedical Technology Solutions,
Inc.
www.bmtscorp.com
Cator, Ruma & Associates
www.catorruma.com
CH2M Hill
www.ch2m.com
Consolidated Building Services
[email protected]
CRB Engineers and Builders
www.crbusa.com
Facility Planning Arts
www.planningartsinc.com
Haldeman-Homme, Inc.
www.haldemanhomme.com
ISEC Laboratory Services
www.isecinc.com
Outsource Facility Solutions, LLC
(OFS)
www.outsourcefs.com
Shaffer Baucom Engineering &
Consulting
www.sbengr.com
The Neenan Company LLP
www.neenan.com
63
Consulting - Engineering
Biologics Consulting Group, Inc.
(BCG)
www.biologicsconsulting.com
CT Associates Incorporated
www.ctassociatesinc.com
BioNimbus
www.bionimbus.com
dBMEDx, LLC
www.dbmedx.com
CARE Research, Inc.
www.care-research.net
Consulting - General Business
Biomedical Communication &
Consulting
[email protected]
Biotech Clarity Consulting LLC
www.biotechclarityconsulting.com
Bridging Health-Matters, LLC
www.bridginghealthmatters.com
ClearMed LLC
[email protected]
Commissioning Agents, Inc.
www.cagents.com
LCC Consulting, LLC
www.lccconsulting.net
Lippert, Inc.
[email protected]
Morningstar Consulting LLC
[email protected]
Neil Burris & Associates
[email protected]
Peak to Peak Pharmaceutical Associates
[email protected]
Shapiro Solutions
www.shapirosolutions.com
Consulting - International
International Business Services of
Colorado (IBSC)
[email protected]
Lynx International
www.lynxcro.com
Consulting - Regulatory,
Commercialization and Development
Affygility Solutions
www.affygility.com
64
CBR International Corporation®
www.cbrintl.com
CytoAnalytics
www.cytoanalytics.com
Emerson Consultants, Inc.
www.emersonconsultants.com
Evergreen Research, Inc.
www.evergreenresearch.com
Evolve Biosciences LLC
www.evolvebiosciences.com
FDA Compliance Group, LLC™
www.fdacg.com
Foresight Science & Technology™
www.foresightst.com
HemoGenix®
www.hemogenix.com
MPI Research
www.mpiresearch.com
NextGen Pharma Technologies, Inc.
www.nextgenpharma.com
Distribution, Packaging and Sales Force
Airgas, Inc.
www.airgas.com
CGL - Concert Group Logistics
www.cglship.com
Doctor to Doctor Sales Solutions
www.doctortodoctorsales.com
Mesa Systems
www.mesasystemsinc.com
MM Solutions
www.mmsolutions.biz
QuickSTAT
www.qicstat.com
The FWA Group Architects
www.fwagroup.com
VWR International, LLC
www.vwr.com
Economic Development
Adams County Economic
Development, Inc. (ACED)
www.adamscountyed.com
Arvada Economic Development
Association
www.aeda.biz
OCAM Solutions, Inc.
www.ocamsolutions.com
Aurora Economic Development
Council
www.auroraedc.com
ORRA Group, LLC
www.orragroup.com
Boulder Economic Council
www.boulderbusiness.org
Pharmatech Oncology, Inc.
www.pharmatech.com
Broomfield Economic Development
Corporation (BEDC)
www.broomfieldedc.com
Promesa Bio, LLC
www.promesabio.com
Reglera, LLC
www.reglera.com
Regulus Pharmaceutical Consulting, Inc.
www.reguluspharma.com
Reimbursement Principles
www.reimbursementprinciples.com
RMC Pharmaceutical Solutions
Incorporated (RMC)
www.rmcpharma.com
Sampson Surgical
www.sampsonsurgical.com
Canadian Consulate
www.international.gc.ca
Colorado Rhône-Alpes Economic
Development Partnership (CORA)
www.coranetwork.org
Colorado Springs Regional
Economic Development
Corporation
www.csedc.org
Jefferson Economic Council
www.jeffco.org
Metro Denver Economic
Development Corporation
www.metrodenver.org
2010/2011
BIOSCIENCE COLORADO
Northern Colorado Economic
Development Corporation
www.ncedc.com
South Metro Denver Chamber of
Commerce
www.bestchamber.com
Equipment Remarketing
Grow, LLC
www.growllc.com
LBN Insurance Agency
www.lbninsurance.com
Hein & Associates LLP
www.heincpa.com
Lockton Companies, LLC
www.lockton.com
High Country Venture, LLC (HCV)
www.coloradofund1.com
Morgenthaler Ventures
www.morgenthaler.com
PBC Inc.
www.pbcinc.com
Silicon Valley Bank (SVB Financial
Group®)
www.svb.com
Finance, Investment and Financial
Services
Apis Business Solutions, LLC
www.apisbusinesssolutions.com
Berkshire Advisor Resource, Inc.
www.berkadvisor.com
Boulder Statistics
www.boulderstats.com
Capital Advisors Group, Inc.
www.capitaladvisors.com
EKS&H (Ehrhardt Keefe Steiner &
Hottman PC)
www.eksh.com
Ernst & Young
www.ey.com
2010/2011
Hotel
Embassy Suites Hotels®
www.embassysuites.com
Incubator
Boulder Innovation Center
www.boulderinnovationcenter.com
Insurance
Commerce Bank
www.realpeoplebank.com
BIOSCIENCE COLORADO
Hensley, Kim & Holzer, LLC (HKH)
www.hke-law.com
Colorado Springs Technology
Incubator (CSTI)
www.cstionline.org
ClearCreek Partners, LLC
www.clearcreekpartners.com
Fairfield and Woods P.C.
www.fwlaw.com
Tobin Ruparel Konczak & Mundell
PC (TRKM, Inc.)
www.trkm.com
Colorado Science + Technology
Park at Fitzsimons
www.colobio.com
Boulder Ventures
www.boulderventures.com
Dorsey & Whitney LLP
www.dorsey.com
Fulbright & Jaworski, L.L.P.
www.fulbright.com
The Brown Palace Hotel and Spa
www.brownpalace.com
Aweida Venture Partners
www.aweida.com
Cooley Godward Kronish LLP
www.cooley.com
TaxOps, LLC
www.taxops.com
UMB Bank
www.umb.com
Extronex, Inc.
www.extronex.com
Legal Services
Chubb Group of Insurance Companies
www.chubb.com
CoBiz Insurance/CoBiz Financial
www.cobizins.com
Hogan & Hartson, LLP
www.hhlaw.com
Holland & Hart LLP
www.hollandhart.com
Jondle & Associates P.C.
www.jondlelaw.com
Kendall Koenig & Oelsner P.C.
(KKO)
www.kkofirm.com
Marsh Fischmann & Breyfogle LLP
www.mfblaw.com
McKenna Long & Aldridge LLP
www.mckennalong.com
Polsinelli Shughart PC
www.polsinelli.com
Sheridan Ross PC
www.sheridanross.com
Snell & Wilmer L.L.P.
www.swlaw.com
Swanson & Bratschun L.L.C.
www.sbiplaw.com
The McGaw Law Firm, P.C.
www.mcgawlaw.com
The Rigney Law Office LLC
www.krigneylaw.com
Trusted GC
www.trustedgc.com
65
Marketing, Communications and
Public Relations
Scout IR (Scout Investor
Relations)
www.scoutir.com
Absolutely Public Relations
www.absolutelypr.com
Biolexica
www.biolexica.com
The Strong Group
[email protected]
BioPharm International
www.biopharminternational.com
Ubiquity specializes in medical
technology marketing. We help
companies:
Burns Marketing
Communications
www.burnsmarketing.com
• Create awareness
• Generate demand
• Retain customers
• Measure success
Business Wire
www.businesswire.com
Casey Demchak Copywriter &
Consultant
www.caseydemchak.com
Say hello: [email protected]
Let’s talk: 303.962.8700
3/1/10 Ubiquity
4:3
Group
UP TO OUR
OWN DEVICES.
www.ubiquity-design.com
Meeting and Incentives Planning
TM
35 years of award-winning
achievement in medical device
marketing communications,
and our best is yet to come.
Planning Partners International, LLC
www.ppimeetings.com
Professional Services Firm
303-443-7602 | 800-445-7602 | www.griffsmc.com
Griff/SMC Marketing
Communications, Inc.
www.griffsmc.com
Hillside Communications, Inc.
www.hillsidecommunications.com
HOWE Creative
www.howecreative.com
Hyper Dog Media
www.hyperdogmedia.com
JohnstonWells Public Relations
www.johnstonwells.com
Kaleidoscope Group
303-667-9265
Paul L. Anderson Productions,
Inc.
www.paulanderson.com
66
Fitzsimons Life Science District
www.colobio.com
Forest City Stapleton
www.forestcity.net
Freeman Myre Inc.
www.freemanproperty.com
Jones Lang LaSalle®
www.joneslanglasalle.com
Recruiting, Placement, and
Workforce
Blue Marble Enterprises, Inc.
www.blue-marble.com
GriffSMC_DirectoryAd_2010-D2
Citizen
Pictures, LLC
www.citizenpictures.com
PROMOTECH (an inVentiv Health
company)
www.promotechdirect.com
TriNet Group Inc.
www.trinet.com
VCFO©
www.vcfo.com
Administaff
www.administaff.com
Aerotek Scientific, LLC
www.aerotek.com
Arapahoe/Douglas Works!
Workforce Center
www.adworks.org
CoreLogic, Inc
www.corelogicinc.com
EFL Associates, Inc.
www.eflassociates.com
Elsner Scientific Search, LLC
www.elsnersearch.com
Jefferson County Workforce
Center
www.jeffcoworkforce.org
Kelly Scientific Resources®
www.kellyscientific.com
Lab Support (division of On
Assignment)
www.onassignment.com
Supplier
Public Policy
Boyle Silver & Weist Policy Strategist Inc. (BSW)
www.rbwpolicy.com
PhRMA
www.phrma.org
We Work for Health
www.weworkforhealth.org
Real Estate
CB Richard Ellis Group, Inc. (CBRE)
www.cbre.com
IdentiGEN North America, Inc.
www.identigen.com
Training and Education
Knowledge-Forge
www.knowledge-forge.com
Medical Simulation Corporation
www.medsimulation.com
Touch of Life Technologies, Inc.
www.toltech.net
2010/2011
BIOSCIENCE COLORADO
Precision
it’s true. we find
ourselves immersed
in the details.
The miniscule, tiny – often microscopic details.
At LABS, Inc. we are committed to guiding you through the maze
of regulated testing requirements for your device, biologic or
stem cell regenerative medicine product. We leverage our
expertise in the biological sciences with our proclivity for
delivering accurate, timely and reliable results. LABS, Inc. is
your ideal partner to help move your idea from concept and
development through scale-up and commercialization.
labs’ core competencies
microbiology
cell & molecular biology
immunogenetics
infectious disease screening
sample logistics & transit solutions
www.LABS-inc.org
6933-B S. Revere Pkwy., Centennial, CO 80112
Technical Sales Team 720.528.4799 / Toll Free 800.321.6088

Directory - Colorado BioScience Association

Transcription

Similar documents

January Newsletter 2016

The Denver Post

Seafood and Sandals

Jennifer Pitt - Colorado Mesa University

P.O.S.H. Couture Rentals

The Art of Summer - Colorado Youth Ballet

95% - Directorio Mi Gente

the 2012 Annual Report

110 volunteer champions 2 short months

2006 - Fall - Rocky Mountain Classics