5th Lugano Stem Cell Meeting 20th – 21st June 2016

5
Th
5 th Lu g a n o
St e m C e ll
M eet i n g
20th – 21st June
2016
Università della Svizzera Italiana
Lugano
Switzerland
FI N A L P RO G RA M
www.sirm-institute.ch/lscm
ORG A N IZ E D B Y
Associated Institute
of the University of Zurich
M A IN S P O N SO R S
Dipartimento delle finanze e dell’economia
Divisione dell’economia
F I N AL P ROG RAM
Introduction
Basic and translational research on stem cells for regenerating injured organs, including the heart and the brain, has
experienced tremendous progress over the past decade.
Besides cell types traditionally used in regenerative protocols, such as bone marrow-derived cells and mesenchymal
stem cells, new candidate cell types for cardiac repair have
emerged, most notably cardiac-resident stem and progenitor cells. Meanwhile, induced pluripotent stem (iPS) cells
provide a unique opportunity of disease modelling and
personalized medicine. The roles of molecular mediators
of stem cell effects, such as paracrine factors including
exosomes and noncoding RNA, are increasingly well understood and exploited in therapeutic strategies.
The fifth edition of the Lugano Stem Cell Meeting provides
a unique opportunity to discuss the above scientific issues
with worldwide leaders in the field within a particularly
comfortable context. As for the previous editions of the
Meeting, the first day will be focused on basic research
while the second day will be more specifically devoted to
clinical applications and cell therapy trials. Spotlight sessions of this edition will highlight exosomes as paracrine
mediators of functional effects of stem cells, noncoding RNA as critical regulators of cell function, and stem
cell-based approaches for the treatment of neurological
diseases.
We look forward to welcoming you in Lugano,
Prof. Piero Anversa
Dr. Lucio Barile
Prof. Tiziano Moccetti
Dr. Daniel Sürder
Prof. Giuseppe Vassalli
F I N AL P ROG RAM
M O N DAY 2 0
TH
JUNE 2016
M O R N I N G M O N D A Y 2 0
08:30 – 09:00 09:00 – 09:10
09:10 – 09:20 T H
J U NE 2016
Registration
Welcome Address - T. Moccetti
Introduction - G. Vassalli
SESSION 1
Cellular and non cellular approaches for heart dysfunction
Chairman: G. Pompilio
Panel: O. Binah, P. Ferdinandy, C. Gaetano
09:20 – 09:35 09:35 – 09:50 09:50 – 10:05
Autophagy-lysosomal pathway alterations in heart failure - A. Beltrami
Fate of cardiac stem cells in the adult heart - A. Leri
Long non-coding RNAs in post-ischemic heart failure - F. Martelli
10:05 – 10:35 Lecture
Molecular approaches for cardiac regeneration - M. Giacca
10:35 – 11:00
Coffee break - POSTER SESSION
SESSION 2
Extracellular vesicles: Emerging biomarkers and therapeutics
Chairman: A. Leri
Panel: G. Camussi, G. Vassalli
11:00 – 11:15 Heterogeneous populations of extracellular vesicle subtypes - J.P. Sluijter
11:15 – 11:30
Cardiac exosomes for cardiac repair - L. Barile
11:30 – 11:45
Functional genomics of cardioprotection: role microRNAs and exosomes
P. Ferdinandy
Lecture
11:45 – 12:15
Exosomes as therapeutic agents - E. Marbán
12:15 – 13:10Lunch - POSTER SESSION
F I N AL P ROG RAM
M O N DAY 2 0
th
JUNE 2016
A F T E R N O O N M O N D A Y 2 0
t h
J U N E 2016
SESSION 3
Cardiomyocytes specification from ESC or iPS
Chairman: J.P. Sluijter
Panel: C. Altomare, L. Barile, A. Beltrami
13:10 – 13:25
13:25 – 13:40
13:40 – 13:55
iPS cell-derived cardiomyocytes - P. Dell’Era
Modelling congenital heart diseases with human embryonic stem cells:
the case of Down syndrome - M. Jaconi
Electrophysiology of iPS cell-derived cardiomyocytes - O. Binah
13:55 – 14:25 Lecture
Calcium handling in human induced pluripotent stem cell derived
cardiomyocytes
L. Gepstein
SESSION 4
Neuroregeneration
Chairman: P. Paganetti
Panel: A. Faedo
14:25 – 14:45
14:45 – 15:05
Molecular and cellular control of neural stem cell activity - S. Jessberger
Attempts to characterize the limited capacity of the mammalian retina
to regenerate photoreceptors - Y. Arsenijevik
15:05 – 15:35
Lecture A differentiation toolkit for the derivation of neurons from pluripotent
stem cells, the example of Huntington’s Disease - A. Faedo
Coffee break - POSTER SESSION
15:35 – 16:15
SESSION 5 The big debate on meta analysis in cardiac regeneration
Chairman: A. Mathur
Panel: D. Locca, G. Pedrazzini
16:15 – 16:27
16:27 – 16:39
Why I prefer IPD based meta-analyses - M. Gyöngyösi
16:39 – 16:51
16:51
– 17:05
How can they come together - A. Zeiher
Discussion
Why I prefer publication based meta-analyses - B. Dawn
SESSION 6
Vascular aging, regeneration and diabetes
Chairman: S. Dimmeler
Panel: A. Beltrami, G. Vassalli
17:05 – 17:20
Translating metabolism into cardiovascular epigenetics - C. Gaetano
17:20 – 17:35
Molecular mechanisms of age-related endothelial dysfunction and CVD
G. Camici
17:35 – 17:50
Endothelial progenitor cell-derived exosomes - G. Camussi
17:50 – 18:00
POSTER AWARD - T. MOCCETTI
F I N AL P ROG RAM
T U E S DAY 2 1
ST
JUNE 2016
M O R N I N G T U E S D A Y 2 1
s t
J U NE 2016
08:00 – 08:20
08:20 – 08:30
Registration
Welcome address - D. Sürder
SESSION 7
How to design animal models in regeneration cardiovascular research
translation of the unmet need
Chairman: P. Anversa
Panel: J. Kastrup, W. Wojakowski
08:30 – 08:42 Good cardiac regeneration comes in small animals: myth or fact - V. Lionetti
08:42 – 08:54 Large animal models - M. Emmert
08:54 – 09:05Discussion
SESSION 8 Now it counts! Update on planned, resumed and ongoing trials
Chairman: A. Zeiher
Panel: R. Corti, G. Pompilio
09:05 – 09:17 The CHART program – preliminary results and future objectives - A. Mathur
09:17 – 09:29 DREAM-HF- Will the dream become true? - E. Perin
09:29 – 09:41
i.c. CD133+ cells in patients with No-option resistant angina results from the REGENT-VSEL trial - W. Wojakowski
09:41 – 09:53 Update on clinical trials of allogeneic CDCs: ALLSTAR, DYNAMIC
and HOPE-Duchenne - E. Marbán
09:53 – 10:05
Update on the Copenhagen ASC program - M. Haack-Sørensen
10:05 – 10:17
Update on the STEM-AMI OUTCOME trial - F. Achilli
10:17 – 10:29
Study design, rationale and status of the ESCORT trial - P. Menasché
10:29 – 10:45Discussion
10:45 – 11:15
Coffee break
11:15 – 11:45
Lecture
The RNA world: targeting novel RNA species for cardiovascular repair
S. Dimmeler
11:45 – 12:00
Closing Remarks - T. Moccetti
12:00 – 13:30Lunch
13:30 – 14:15 Special Joint Lecture
Chairmen: T. Moccetti, M. Moccetti, E. Fretz
Long Duration Space Mission: Medical Risk - O. J. Atkov
End of the 5th Lugano Stem Cell Meeting
C O U RS E DIRECTO RS - FAC ULTY
S P O NSORS
COURSE DIRECTORS
P. Anversa, Lugano – Switzerland
L. Barile, Lugano – Switzerland
T. Moccetti, Lugano – Switzerland
P. Paganetti, Lugano – Switzerland
D. Sürder, Lugano – Switzerland
G. Vassalli, Lugano – Switzerland
FACULTY
F. Achilli, Monza – Italy
Y. Arsenijevik, Lausanne – Switzerland
O. Atkof, Moscow – Russia
A. Beltrami, Udine – Italy
O. Binah, Haifa – Israel
G. Camici, Zürich – Switzerland
G. Camussi, Torino – Italy
R. Corti, Zürich - Switzerland
B. Dawn, Kansas –USA
P. Dell’Era, Brescia – Italy
S. Dimmeler, Frankfurt - Germany
M. Emmert, Zürich - Switzerland
A. Faedo, Milano – Italy
P. Ferdinandy, Budapest – Hungary
S P O NSORS
C. Gaetano, Frankfurt – Germany
L. Gepstein, Haifa – Israel
M. Giacca, Trieste – Italy
M. Gyöngyösi, Wien – Austria
M. Haack-Sørensen – Copenagen – Denmark
M. Jaconi, Geneve – Switzerland
S. Jessberger, Zürich – Switzerland
V. Lionetti, Pisa - Italy
D. Locca, Lausanne - Switzerland
E. Marbán, Los Angeles – USA
F. Martelli, Milano – Italy
A. Mathur, London - UK
P. Menasché, Paris –France
E. Perin, Houston – USA
G. Pompilio, Milano - Italy
J. P. Sluijter, Utrecht –Netherlands
W. Wojakowski, Katowice - Poland
A . Zeiher, Frankfurt - Germany
LOCAL FACULTY
C. Altomare, E. Cervio, A. Leri,
G. Milano, G. Pedrazzini
G E N ERA L I NFO R MAT IO N
LOCATION
The 5th Lugano Stem Cell Meeting (LSCM) 2016
will take place in Lugano, the most important city
in the Italian speaking part of Switzerland. This
region is considered one of the most beautiful
spots in Europe.
VENUE
The Symposium will take place at the Università della Svizzera Italiana, which is located 10
minutes walking distance of many hotels, shops
and attractions. The venue is centrally located,
and 30 minutes by taxi from the local airport
(Lugano-Agno). The Milan Malpensa Airport is 1
hour by shuttle-bus from Lugano.
By car: motorway exit Lugano Nord.
CLIMATE
June often presents a warm temperature (2327°C), with possible rain-showers.
CERTIFICATE OF ATTENDANCE
A Certificate of Attendance will be given to the
participants attending all sessions of the Symposium.
ACCREDITATION
FAMH: 10,5 credits (pending approval)
CONFERENCE LANGUAGE
The conference language is English for all sessions. No translation is provided.
POSTER SESSION
Call for abstracts on the website www.cardiocentro.org. The bestposter will be awarded and
will be presented as an oral presentation on June
20th.
Deadline poster submission: June 10th, 2016
HOTEL ACCOMMODATION
Participants are responsible for their own hotel
booking.
For assistance please contact:
Amiconi Consulting
Via Al Forte 10
6900 Lugano, Switzerland
Phone: +41 91 921 38 12
Fax: +41 91 921 38 13
[email protected]
WEB SITE
On the official conference website
www.sirm-institute.ch/lscm
you’ll find more information about:
•
Organizing institutions
•Venue
• Scientific program
•
Abstract submission
Registration form:
www.sirm-institute.ch/lscm/registration
Abstract submission form:
www.sirm-institute.ch/lscm/abstract
CONFERENCE SECRETARIAT
Please contact the secretariat in case of any
query at the following address:
Events and Communication Department Cardiocentro Ticino
Via Tesserete 48
CH - 6900 Lugano
Phone: +41 91 805 31 93 / 33 78
Fax: +41 91 805 38 13
[email protected]
5 th L u g a no
St em C ell
M eet i ng
20th-21st June 2016
Università della Svizzera Italiana
Lugano - Switzerland
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Registration fees
Free registration for academy participants
Euro 250 for industry participants
Free registration for congress sponsors
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REGISTRATION FORM
DEADLINE FOR REGISTRATION
1 ST J U N E 2 0 1 6
TO BE RETURNED WITH ENCLOSURES TO
Fondazione Cardiocentro Ticino
Events and Communication Department
Via Tesserete 48
CH-6900 Lugano
Phone +41 91 805 33 78 /31 93 - Fax +41 91 805 38 13
[email protected]
www.sirm-institute.ch/lscm
Associated Institute
of the University of Zurich