Cooper: Excercise for Life Presentation
Transcription
Cooper: Excercise for Life Presentation
Exercise for for Life Life Exercise Kenneth H. Cooper, M.D., M.P.H. Chairman & Chief Executive Officer Cooper Clinic 12200 Preston Road Dallas, Texas Boston.rev.4.24.09 1 American Adult Exercise Habits 1968 -1990 1968-1990 Exercising Jogging 1968 < 24 % < 100,000 1984 59 % 1990 40 % 34 million 30 million 48 % ↓ CVD Boston.rev.4.24.09 Russia: ↑ 31 % Poland: ↑ 36 % Hungary: ↑ 40 % Romania: ↑ 60 % 2 American Adult Exercise Habits 1968 -1990 1968-1990 Medical Treatment 33 % 1968 - 1990 Lifestyle Change 67 % Cigarette Smoking Blood Pressure Control Cholesterol Reduction Stress Management Increased Activity CV Deaths ↓ 48 % News: Health & Behavior June June 7, 7, 2007 2007 Lowering Heart Risk Saves as Many Lives as Treatment 1980 - 2000 Medical Treatment 48 % CV Deaths ↓ 40 % Lifestyle Change 52 % Cigarette Smoking Blood Pressure Control Cholesterol Reduction Increased Activity *NN Eng Eng JJ Med, Med, Vol. Vol. 356, 356, No. No. 23, 23, June June 7, 7, 2007, 2007, pp 2389-2398 2389-2398 Boston.rev.4.24.09 3 January January 23, 23, 2008 2008 Cardiovascular Disease Death Rates 19991999-2005 Strokes / 100,000 Heart Disease / 100,000 1999 2005 195 144 25.8 % 24.4 % Medical Lifestyle Change • Early Detection • Treatment • Cigarette Smoking • Blood Pressure Control • Cholesterol Reduction • Increased Activity January January 23, 23, 2008 2008 Cardiovascular Disease Death Rates 19991999-2005 Early Detection • Resting and Stress ECGs • Resting and Stress Echocardiograms • Nuclear Scans • CT Scans for Early Calcification • CT Angiograms Boston.rev.4.24.09 61 47 Treatment • Pharmaceutical • Blood Lipids • Angioplasties (with stents) • Bypass Surgery 4 WARNING ““Signs Signs of trouble loom on the horizon, among them twin epidemics of diabetes and obesity in young people. people.”” National National Center Center for for Health Health Statistics, Statistics, January January 23, 23, 2008 2008 Adopting A Healthy Lifestyle 3 5 or more Fruits and Vegetables 3 Regular Exercise 3 No Smoking 3 BMI 18.5 – 29.9 • • • 15,708 Men and Women -64 years of age 45 Women 4545-64 st st 8.5% 1 visit: visit: 8.5% all all 44 6 years later: 8.4% all later: 8.4% all 44 (new (new adopters) adopters) After only 4 years NA Total Mortality CV Mortality N/C 2.5% 4.2% (40% ↓) 11.7% 16.5% (35% ↓) Dana Dana King, King, MD, MD, MS, MS, et et al, al, Am Am JJ Med, Med, July July 2007 2007 Boston.rev.4.24.09 5 Adopting A Healthy Lifestyle • The Healthy Aging & Longitudinal Study in Europe (HALE) 1507 men, 832 women, 70-90 years of age 70 70-90 3 3 3 3 3 3 3 3 After 10 yrs Mediterranean Mediterranean Diet Diet Moderate Moderate Alcohol Alcohol Use Use Physically Physically Active Active No No Smoking Smoking 65% -cause mortality all 65% ↓ ↓ in in allall-cause mortality and and CV CV disease disease • The Health Professionals Follow-Up Study Follow Follow-Up Study (Men) (Men) 3 3 55 Factors Factors After 16 yrs 62% 62% ↓ ↓ in in coronary coronary events events Dana Dana King, King, MD, MD, MS, MS, et et al, al, Am Am JJ Med, Med, July July 2007 2007 Multiple Cardiovascular Risk Factors • 50% men and almost 40% women in the U.S. will develop CVD. • For men and women with no risk factors at age 50, the risk of CVD had been essentially abolished. • 3564 men, 4362 women (Framingham Study): No CVD at age 50. • Survival for men: 80 years Survival for women: 86 years • Obesity ↑ CVD risk: 58% for men, 43% for women Circulation, Circulation, Feb Feb 14, 14, 2007 2007 Boston.rev.4.24.09 6 35 29 30 20 20 17 ru gs 47 43 D In fe ct io n 75 Se x 90 lc oh ol A cc o ie t/E xe rc is e 85 Tobacco Sex Related Motor Vehicles Guns G un s 100 eh .* 300 *Alcohol-related deaths: 1990 – 22,084 2000 – 16,653 D To Drugs Diet/Exercise Alcohol Infection 365 M .V 435 400 450 400 350 300 250 200 150 100 50 0 ba Deaths (1000's) Actual Causes of Death 1990 /2000 Source: JAMA, Mar 10, 2004, Vol. 291, No. 10. Body Mass Index BMI = (Weight in pounds) (Height in inches) x (Height in inches) Examples Range BMI Boston.rev.4.24.09 130 65 x 65 x 703 = 21.7 BMI 165 65 x 65 x 703 = 27.5 BMI < 25 25 – 30 > 30 x 703 Normal Overweight (66 %) Obese (34 %) 7 Obesity Trends* Among U.S. Adults BRFSS, 1990 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” woman) No Data <10% 10%–14% Obesity Trends* Among U.S. Adults BRFSS, 2006 (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data Boston.rev.4.24.09 <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% 8 Source: “Mending Broken Hearts,” National Geographic, Feb. 2007 Diabetes Trends* Among Adults in the U.S., (Includes Gestational Diabetes) BRFSS 2005 No Data < 5% 5 – 5.9% 6 – 6.9% 7 – 7.9% 8+% Source: Mokdad et al., Diabetes Care 2000;23:1278-83. Boston.rev.4.24.09 9 Relative Risk of Death from Cancer Contribution of Overweight and Obesity to Mortality from Cancer in the United States 2 1.5 1 0.5 0 18.5 - 24.9 25.0 - 29.9 30.0 - 34.9 35.0 - 39.9 ≥40 Body-Mass Index Source: Cancer Prevention Study II, 1982 – 1998. Boston.rev.4.24.09 Men Women 10 How is Obesity Determined In Children? Boston.rev.4.24.09 11 Body Mass Index BMI = (Weight in pounds) (Height in inches) x (Height in inches) x 703 OR PERCENT BODY FAT as determined by skinfold measurements Obese: Overweight: Top 5 percentile Top 15 percentile Proportion of Overweight Children in the United States 1963-1970 1976-1980 1999-2000 2000-2004 18.8% 20% 15.5% 15.3% 15% 10% 6.5% 4.2% 4.6% 5% 5% 0% 6-12-year-olds 12-19-year-olds Source: Centers for Disease Control and Prevention, 2003. Boston.rev.4.24.09 12 Obesity Projections in America – Adults and Children (2010 – 2048) Overweight 2010 2030 2048 2030 Adults Obese 66.3% 36% Children 40% 20% Adults 86.3 51% Children 80% 40% Adults 100% Overweight or Obese Cost of Obesity = $860.7- $956.9 Billion Black women and Mexican-American men most affected Source: Obesity, Vol. 16, no. 10, October 2008 There is an epidemic of adult -onset diabetes being adult-onset seen in children. It is estimated that among children born after the year 2000: • 1 out of 3 children will develop diabetes (higher in Hispanics and African-Americans) African African-Americans) If they develop adult -onset diabetes before 14 years adult-onset of age, it is estimated that that will shorten their lifespan by 17 to 27 years. As a result, this may be the first generation in which parents live longer than their children. Boston.rev.4.24.09 13 Stanford Achievement Test Ninth Edition (SAT-9) 2004 FITNESSGRAM®® Tests AEROBIC CAPACITY #1 PACER (Progressive Aerobic Cardiovascular Endurance Run) Set to music, a paced, 20-meter shuttle run increasing in 20 20-meter intensity as time progresses. Or: • One-Mile Run One One-Mile Students run (or walk if needed) one mile as fast as they can. • Walk Test Students walk one mile as fast as they can (for ages 13 or above since the test has only been validated for this age group). Boston.rev.4.24.09 14 FITNESSGRAM®® Tests BODY COMPOSITION #2 Skin Fold Test Measuring percent body fat by testing the triceps and calf areas. Or: • Body Mass Index (BMI) Calculated from height and weight FITNESSGRAM®® Tests MUSCULAR STRENGTH AND ENDURANCE #3 Curl-Up Curl Curl-Up Measuring abdominal strength and endurance, students lie down with knees bent and feet unanchored. Set to a specified pace, students complete as many repetitions as possible to a maximum of 75. Boston.rev.4.24.09 15 FITNESSGRAM®® Tests MUSCULAR STRENGTH AND ENDURANCE #4 Trunk Lift Measuring trunk extensor strength, students lie face down and slowly raise their upper body long enough for the tester to measure the distance between the floor and the student’ ’s chin. student student’s FITNESSGRAM®® Tests MUSCULAR STRENGTH AND ENDURANCE #5 Push-Up Push Push-Up Measuring upper body strength and endurance, students lower body to a 90-degree elbow 90 90-degree elbow angle angle and push up. Set to a specific pace, students complete as many repetitions as possible. Or: • Modified Pull-Up (proper equipment required) Pull Pull-Up With hands on a low bar, legs straight and feet touching the ground, students pull up as many repetitions as possible. • Flexed Arm Hang Students hang their chin above a bar as long as possible. Boston.rev.4.24.09 16 FITNESSGRAM®® Tests FLEXIBILITY #6 Back-Saver Sit and Reach Back Back-Saver Testing one leg at a time, students sit with one knee bent and one leg straight against a box and reach forward. Or: • Shoulder Stretch With one arm over the shoulder and one arm tucked under behind the back, students try to touch their fingers and then alternate arms. Boston.rev.4.24.09 17 2004 CST* Scores in Math by Number of Fitness Standards Grade 5 – 371,198 Students Grade 7 – 366,278 Students Grade 9 – 63,028 Students** CST Math Score Grade 5 Grade 7 Grade 9 370 360 350 340 330 320 310 300 290 280 0 1 2 3 4 5 6 Number of Fitness Standards Achieved *California Standards Test ** Grade 9 Students who took CST geometry Source: California Physical Fitness Test, 2004 Results, Calif. Dept. of Ed., April 2005 2004 CST* Scores in English-Language Arts English English-Language by Number of Fitness Standards Grade 5 – 371,198 Students Grade 7 – 366,278 Students Grade 9 – 298,910 Students Grade 5 Grade 7 Grade 9 CST E-LA Score 360 350 340 330 320 310 300 290 0 1 2 3 4 5 6 Number of Fitness Standards Achieved *California Standards Test Source: California Physical Fitness Test, 2004 Results, Calif. Dept. of Ed., April 2005 Boston.rev.4.24.09 18 2004 CST* Scores in English-Language Arts in Grade 5 English English-Language By Gender and Number of Fitness Standards 371,198 Students (182,287 Female and 188,921 Male) Female Male CST E-LA Score 370 360 350 340 330 320 310 300 0 1 2 3 4 5 6 Number of Fitness Standards Achieved *California Standards Test Results using math scores were consistent with those using English-Language Arts scores. Results for seventh- and ninth-grade students were consistent with those for fifth graders. Source: California Physical Fitness Test, 2004 Results, Calif. Dept. of Ed., April 2005 2004 CST* Scores in English-Language Arts in Grade 5 English English-Language by Socioeconomic Status** and Number of Fitness Standards 371,198 Students (203,726 NSLP and 167,472 Non-NSLP) Non-NSLP NSLP CST E-LA Score 380 370 360 350 340 330 320 310 300 0 1 2 3 4 5 6 Number of Fitness Standards Achieved *California Standards Test **National School Lunch Program Results using math scores were consistent with those using English-Language Arts scores. Results for seventh- and ninth-grade students were consistent with those for fifth graders. Source: California Physical Fitness Test, 2004 Results, Calif. Dept. of Ed., April 2005 Boston.rev.4.24.09 19 Early-Onset Obesity and Its Effect on I.Q. 106 120 120 78 I.Q. Score Score I.Q. 100 100 80 80 63 60 60 40 40 20 20 00 Prader-Willi Syndrome* (19 children & 5 adults) *Prader-Willi Syndrome is a genetic deficiency which causes marked obesity before age 6. Siblings: 150% Ideal Weight before age 6 (18 children & adults) Siblings: Normal Weight (24 children & adults) Source: Miller, et al, J of Ped, Vol. 149, Issue 2, Aug 2006, 192-198.e3 “… discovered a link between marked obesity in toddlers and lower IQ scores, cognitive delays, and brain lesions similar to those seen in Alzheimer’s disease patients.” Source: Miller, et al, J of Ped, Vol. 149, Issue 2, Aug 2006, 192-198.e3 Boston.rev.4.24.09 20 " … emerging research showing that physical activity sparks biological changes that encourage brain cells to bind to one another. For the brain to learn, these connections must be made." " … exercise provides an unparalleled stimulus, creating an environment in which the brain is ready, willing, and able to learn." "Exercise is fertilizer for the brain." "Spark: The Revolutionary New Science of Exercise and the Brain," John J Ratey, MD, 2008. Senate Bill Bill 530 530 Senate Passed by by Texas Texas State State Passed House of of Representatives Representatives and and House Senate on on May May 27, 27, 2007 2007 Senate Signed into into Law Law by by Signed Governor Rick Rick Perry Perry Governor on June June 13, 13, 2007 2007 on approved as as official official testing testing Fitnessgram approved Fitnessgram vehicle by by the the Texas Texas Education Education Agency Agency vehicle on September September 27, 27, 2007 2007 on ®® Boston.rev.4.24.09 21 Senate Bill 530 Exercise Requirements (Sep 2007) Grades 1 – 5 • 30 minutes 5 times/week or • 45 minutes 3 times/week (135 minutes total) • 225 minutes over 2 weeks (45 minutes 3 times the first week, 45 minutes 2 times the second week) Grades 6 – 8 • Same as above, but only 4 of 6 semesters are required Grades 9 – 12 • No physical education requirement Testing Requirements (using the Fitnessgram® Fitnessgram®) • Beginning in the 20072007-08 school year, all students grades 3 - 12 will be required to be tested annually at some time during the school year. Boston.rev.4.24.09 22 Texas Texas Youth Youth Evaluation Evaluation Project Project 2008 2008 Total -12: 2,658,665 33-12: Total ## of of Students Students Grades Grades 32,658,665 Grade FITNESSGRAM® Test % Achieving Healthy Fitness Zone on all 6 tests Total # Students Girls Boys 3 102,342 33.25 28.60 4 80,539 28.50 21.14 5 66,798 23.82 17.89 6 60,663 23.08 17.60 7 55,441 21.32 17.26 8 48,971 18.99 17.88 9 39,456 13.90 15.04 10 28,650 12.42 13.70 11 21,152 10.68 12.24 12 13,040 8.18 8.96 6,532 campuses out of 9,212 (70.91%) 1,074 districts out of 1,267 (84.77%) Texas Education Agency Physical Fitness Assessment Initiative 10 Variables Compared with Levels of Fitness • Attendance Rate • Eligible for free lunch program • Eligible for reduced lunch program • TAKS • Occurrence of substance abuse • Occurrence of violence • Occurrence of weapons • Occurrence of truancy _____________________________ • Obesity • Diabetes Boston.rev.4.24.09 23 Dallas, Texas Tuesday, March 10, 2009 Association Between Fitness and School Attendance Rates 0.52 Correlation Coefficient 0.6 All students from all eligible schools 0.5 0.4 0.3 0.18 0.2 0.1 Spearmen correlations between % achieving HFZ and % attendance (PEIMS data) adjusted for SES, minority % and school size 0 CV (HFZ) BMI (HFZ) Higher Levels of Fitness Associated with Better School Attendance Texas Youth Fitness Study Boston.rev.4.24.09 24 Association Between Fitness and Academic Performance (TAKS) 0.54 Correlation Coefficient 0.6 All students from all eligible schools 0.5 0.4 0.30 0.3 0.2 0.1 Spearmen correlations between % achieving HFZ and % achieving TAKS standards adjusted for SES, minority % and school size 0 CV (HFZ) BMI (HFZ) Higher Levels of Fitness Associated with Better Academic Performance Texas Youth Fitness Study Association Between Fitness and School Incidence Rates -0.52 -0.24 0 All students from all eligible schools Correlation Coefficient -0.1 -0.2 Spearmen correlations between % achieving HFZ and % of negative incidence adjusted for SES, minority % and school size -0.3 -0.4 -0.5 -0.6 CV (HFZ) BMI (HFZ) Higher Levels of Fitness Associated with Fewer Negative School Incidents Texas Youth Fitness Study Boston.rev.4.24.09 25 Percent Achieving Standards CV Fitness Corresponds with Academic Performance when Schools Stratified by State Rating System 100 90 80 70 60 50 40 30 20 10 0 ry pla m e Ex CV TAKS ed ni z og c Re pta ce Ac ble ta ep cc a Un bl e School Ratings Texas Youth Fitness Study Summary of Texas Youth Fitness Study Initial Results • Significant associations were consistently found between physical fitness and various indicators of academic achievement. • The results were controlled for the influence due to school social economic status, minority status and school size. • The consistent relationships observed support the thesis that physical fitness is associated with academic achievement in school aged youth. These are crosssectional results and cannot be used to infer causality. Boston.rev.4.24.09 26 How do we measure cardiovascular fitness? Boston.rev.4.24.09 27 22 18 BALKE 10 At 25:00 min speed Increases 0.2 mph/per min 6 Grade (%) 14 PROTOCOL 2 Calculated 3.3 mph Speed 0 26 2 4 6 8 10 12 14 16 18 20 22 24 Minutes Definitions Of Fitness Categories For Males Fitness Fitness Category* Category* <30 <30 30 30 -- 39 39 40 40 -- 49 49 50-59 50-59 Very Very Poor Poor <14:59 <14:59 <13:59 <13:59 <12:29 <12:29 <10:02 <10:02 Poor Poor 15:00-18:06 15:00-18:06 14:00 14:00 –– 16:59 16:59 12:30 12:30 15:29 15:29 10:03 10:03 –– 12:59 12:59 Fair Fair 18:07 18:07 –– 22:05 22:05 17:00 17:00 –– 20:59 20:59 15:30 15:30 –– 19:59 19:59 13:00 13:00 –– 16:59 16:59 Good Good 22:06 22:06 –– 26:00 26:00 21:00 21:00 –– 24:42 24:42 20:000 20:000 –– 23:13 23:13 17:00 17:00 20:29 20:29 Excellent Excellent 26:01 26:01 –– 28:59 28:59 24:43 24:43 –– 27:09 27:09 23:14 23:14 –– 26:15 26:15 20:30 20:30 –– 23:59 23:59 Superior Superior 29:00+ 29:00+ 27:10+ 27:10+ 26:16+ 26:16+ 24:00+ 24:00+ *Based *Based on on the the Cooper Cooper Clinic Clinic modified modified Balke Balke treadmill treadmill protocol protocol Boston.rev.4.24.09 28 Definitions Of Fitness Categories For Females Fitness Fitness Category* Category* <30 <30 30-39 30-39 40-49 40-49 50-59 50-59 Very Very Poor Poor <10:29 <10:29 <9:29 <9:29 <7:59 <7:59 <6:14 <6:14 Poor Poor 10:30 10:30 –– 13:15 13:15 9:30 9:30 –– 11:59 11:59 8:00 8:00 –– 10:29 10:29 6:15 6:15 –– 8:29 8:29 Fair Fair 13:16 13:16 –– 17:27 17:27 12:00 12:00 –– 15:20 15:20 10:30 10:30 –– 13:59 13:59 8:30 8:30 –– 11:20 11:20 Good Good 17:28 17:28 –– 20:59 20:59 15:21 15:21 –– 18:59 18:59 14:00 14:00 –16:59 –16:59 11:21-11:21-- 14:03 14:03 Excellent Excellent 21:00 21:00 –24:18 –24:18 19:00 19:00 –– 21:59 21:59 17:00 17:00 –– 20:09 20:09 14:04 14:04 –– 17:00 17:00 Superior Superior 24:19+ 24:19+ 22:00+ 22:00+ 20:10+ 20:10+ 17:01+ 17:01+ **Based Based on on the the Cooper Cooper Clinic Clinic modified modified Balke Balke treadmill treadmill protocol protocol Boston.rev.4.24.09 29 Age--Adjusted All All--Cause Mortality Mortality/10,000 /10,000 Age PY Boston.rev.4.24.09 Age -Adjusted All -Cause Mortality Age-Adjusted All-Cause by Fitness Groups, Men 70 70 60 60 50 50 40 40 30 30 20 20 10 10 00 Low Low 22 33 44 High High Fitness Groups 30 Age--Adjusted All All--Cause Mortality/ Age 10,000 PY Fitness and All -Cause Mortality, Men All-Cause 70 70 60 60 Unfit 50 50 Fit 40 40 30 30 20 20 10 10 00 Very Poor Poor Fair Good Excellent/Superior Health & Longevity Fitness Aerobic Fitness Exercising and Aging • Telomeres are protective tips on bundles of genes inside cells • Every time a cell divides, telomeres get shorter • Aging occurs as cells reach the end of the telomere and die ─ muscle weakens, skin wrinkles, and thinking clouds Arch of Int Med, Jan 28, 2008 Boston.rev.4.24.09 31 Exercise and Aging • 2,401 British Twins Long-term study, length of telomeres measured Long Long-term Exercise (min/wk) Reduction in Age (years) 16:00 Baseline 100:00 5.0 - 6.0 180:00 9.0 Arch of Int Med, Jan 28, 2008 Fitness, Body Composition and Distribution, and Mortality in ACLS Men ● Cohort of 21,925 men, followed an average of 8 years (176,742 manman-years) ● Baseline exclusion for MI, stroke, or cancer ● Outcomes − AllAll-cause mortality (428 deaths) − CVD mortality (144 deaths) ● Exposures − CRF from a maximal exercise test on a treadmill as an objective marker of habitual physical activity patterns − Body composition and fat distribution determined by hydrostatic weighing, sum of 7 skinfolds, and waist circumference Lee CD et al. Am J Clin Nutr 1999 Boston.rev.4.24.09 32 Boston.rev.4.24.09 33 Adjusted RR for All-Cause Mortality by Fitness and % Body Fat Fit Unfit 2.5 Adj RR* 2 *adj for age, exam year, smoking, alcohol, & fam history 1.5 1 0.5 0 Lean Normal Obese <17% 17-<25% ≥25% Body Fat Lee CD et al. Am J Clin Nutr 1999 Adjusted RR for CVD Mortality by Fitness and % Body Fat 4.5 Fit Unfit 4 Adj RR* 3.5 *adj for age, exam year, smoking, alcohol, & fam history 3 2.5 2 1.5 1 0.5 0 Lean <17% Normal 17-<25% Body Fat Obese ≥25 % Lee CD et al. Am J Clin Nutr 1999 Boston.rev.4.24.09 34 Body Fat (BMI), Fitness, and Cancer Mortality (34,410 -year followup) 17 (34,410 men, men, average average age age 43.8, 43.8, 1717-year Fit man--years Rate/10,000 man (top 80%) Unfit (lower 20%) 25 20 15 10 5 0 18.5-24.9 P = 0.001 25.0-29.9 P<0.001 >30 P = 0.01 BMI, kg/m2 ACSM, 2006 Quality of Life Variables by Fitness States (10,331 (10,331 Men Men and and Women) Women) Low (n = 1077) % Moderate High (n = 3555) (n = 5679) % % P for Trend Unexplained Fatigue 25.8 16.3 11.2 < 0.001 Problematic Snoring 49.9 34.8 21.9 < 0.001 Frequent Heartburn 30.9 22.1 12.1 < 0.001 Sexual Problems 11.0 7.4 5.0 < 0.001 29.8 22.2 19.6 < 0.001 9.7 (932*) 7.2 (3126*) 4.6 (4910*) < 0.001 Decreased Sex Drive Impotence (men only) * % (n) Source: ACLS, The Cooper Institute, January 2006 Boston.rev.4.24.09 35 Quality of Life Variables by Fitness States (10,331 (10,331 Men Men and and Women) Women) Low (n = 1077) % Moderate High (n = 3555) (n = 5679) % % P for Trend Chronic Joint or Muscle Pain 34.0 29.3 23.5 < 0.001 Low Back Pain 44.8 41.5 35.4 < 0.001 Frequent Headaches 16.7 15.0 12.0 < 0.001 Difficulty Sleeping 28.7 24.9 21.9 < 0.001 Depression 20.9 15.9 12.9 < 0.001 Anxiety 20.2 16.4 13.6 < 0.001 Source: ACLS, The Cooper Institute, January 2006 Aerobic Fitness 35 Aerobic points/week Run 2.0 miles < 20:00 minutes 4x/week Walk 3.0 miles < 45:00 minutes 5x/week Aerobic dance 45:00 minutes 4x/week Boston.rev.4.24.09 36 Health and Longevity Fitness 15 aerobic points /week Walk 2.0 miles < 30:00 minutes 3x/week Walk 2.0 miles < 35:00 minutes 4x/week Walk 2.0 miles < 40:00 minutes 5x/week Walk 3.0 miles < 45:00 minutes 2x/week Aerobic dance 45:00 minutes 2x/week Boston.rev.4.24.09 37 Boston.rev.4.24.09 38 Boston.rev.4.24.09 39 Boston.rev.4.24.09 40 Boston.rev.4.24.09 41 Boston.rev.4.24.09 42 Boston.rev.4.24.09 43 Boston.rev.4.24.09 44 Boston.rev.4.24.09 45 Boston.rev.4.24.09 46 Boston.rev.4.24.09 47