Chromeleon 7 Operational Simplicity for the Laboratory

Chromeleon 7
Operational Simplicity for the Laboratory
Topics
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Introducing Chromeleon 7
User Interface
Peak Detection Tools
eWorkflows™
Interactive Charting
Reporting
Support for Third Party Instrumentation
Summary
Introducing Chromeleon® 7
• New-generation Chromatography Data System
• “Simply Intelligent”
• Intelligent Functionality - it does everything you need!
• Operational Simplicity™ - everything is fast and easy!
• Simplifies all chromatography processes
Chromeleon® 7 - Operational Simplicity
• Operational Simplicity™ was the core design principle
• Major design rules:
• Minimize number of steps needed to perform any task
• Make all steps easy to understand and easy to use
• Minimize time needed to perform any task
• Major features for Operational Simplicity:
• Modern user interface
• Peak detection and integration tools
• eWorkflows
• Data visualization tools
• Enterprise functionality
USER INTERFACE
User Interface
The Chromeleon User Interface consists of two major parts:
• Chromeleon Console
• Chromatography Studio
Chromeleon Console
• Designed to provide easy navigation through your data
• Provides quick access to:
• Instruments
• Data
• eWorkflows
Console – Quick Access to Information
Navigation
Pane
Category Bars
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Thumbnails – Quick Access to Data
• Quick check to see if
chromatogram ran
properly
• Check for presence /
absence of peaks
• Check quality of
separations
Instruments - ePanels
Provides access to
all instruments on
the network
Direct Control of
Instrument through
controls on ePanel
Chromatography Studio
• Used for All Data Evaluation
• Provides access to every object in the sequence:
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Injection List
Instrument Method
Processing Method
Results
Report Template
Spectral Library
• Opens in separate window on task bar – makes working with multiple
sequences easy
• Uses new “Ribbon” technology introduced in Microsoft Office 2007
Chromatography Studio
Ribbon
Navigation
Pane
Category Bars
New Ribbon Interface
• Provides contextual access to commands and options in the
Studio
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PEAK DETECTION
COBRA™ Detection Algorithm / SmartPeaks™
Peak Detection
• Most time consuming and tedious task in chromatography process:
• Chromatogram Integration
• Chromeleon 7 introduces two new tools to simplify this process:
• Cobra Peak Detection Algorithm / Wizard
• SmartPeaks Integration Assistant
Peak Detection – Cobra
• Cobra is a new algorithm that:
• Finds peak start and end times accurately and consistently
• Requires minimum number of parameters to reach integration goals
• Cobra Wizard provides:
• Fast, guided way to determine initial detection parameters
Peak Detection – Cobra Wizard
Peak Detection – Cobra Wizard
Start Cobra Wizard
Define the integration range
Select the
narrowest peak to
be integrated
Select the smallest peak to be integrated
Peak Detection – Cobra Wizard
And your integration is done!
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Peak Detection - SmartPeaks
• Unique tool for easily reaching your integration goals for unresolved
peaks
• Requires no training
• Great example of Operational Simplicity
• Process is clear and understandable
• Requires only a few steps
• Correctly integrates all unresolved peaks in seconds
Peak Detection – SmartPeaks
Activate SmartPeaks Wizard
Select area of interest
Select the integration you want
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Peak Detection – SmartPeaks
And your integration is done!
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eWORKFLOWS™
The Ultimate in Operational Simplicity
eWorkflows
• eWorkflows automate all chromatography processes
• Applies to all laboratories, for example:
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QA/QC laboratories
Method development laboratories
Research & Development laboratories
Walk-up instrument workflows
• Takes you from Samples to Results in only a few steps
eWorkflows
• An eWorkflow brings together all aspects of a chromatography run:
• Instruments which are allowed to run this application
• All associated files:
• Instrument Methods
• Processing Methods
• Reports
• Spectral Libraries
• Documents with description of method
• Template for sequence name and storage location
• Custom Variables
• Rules for sequence layout
eWorkflows – A Regulated USP/EP Method
Sequence is created and
can be immediately run
Choose
eWorkflow,
select
instrument, and
click “Start”
Enter number
of samples,
and start
position
eWorkflows – A Regulated USP/EP Method
• This eWorkflow also:
• Processes all data
• Calculates all results
eWorkflows – From Samples to Results
• eWorkflows take you from Sample to Results in the minimum number of
steps
• Fully customizable for any application
• Minimum amount of training required
• Reduces errors and produces results faster
• A new framework for Operational Simplicity
INTERACTIVE CHARTING
Data Visualization
• Interactive Charts for Data
Visualization
• Fully customizeable
• Templates for the most
common tasks
• Available for both on-screen
and printed/exported reports.
Interactive Charting
● Various Chart types
Pie Chart 2D /
3D
Stacked Column 2D /
3D
Scatter Plot
Interactive Charting: Examples
Product Stability
Query performed on SQL Server
database on all data (including historical)
Active Rel.Area % vs. Impurity Rel.Area %.
Interactive Charting: Examples
Instrument Utilization
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Interactive Charting: Examples
Column Performance
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REPORTING
Spreadsheet Based Reporting
• The Excel-like report
environment is both
familiar and intuitive.
• If Excel is used for
additional calculations
they can be included in
Chromeleon.
• No data transcription or
export to Excel is
required.
• Results are generated
instantly.
Spreadsheet Based Reporting
Excel-like formulae can be
included for custom
calculations
In this case the operator has
configured a report to flag
out of specification results.
Report Designer - Functions
Many Excel-like functions available – use identical syntax
AVERAGE
IF / AND / OR
STDEV
COUNT
SUM
LOOKUP
etc……
Report Designer – Export Options
1. TXT
2. PDF
3. XLS
SUPPORT FOR THIRD PARTY INSTRUMENTS
Instrument Control
• Chromeleon 7 can control Thermo Scientific
LC, GC and IC.
• Chromeleon 7 can control 3rd Party LCs and
GCs
• Agilent 1100, 1200, 1260, 1290, G1888,
6850, 6890, 7890
• Waters Acquity, Alliance
• Shimadzu LC10, LC2010, LC20
• Chromeleon 6.8 controls over 330 different
modules from 30 different manufacturers.
• These drivers are being converted to CM7
Interfacing with 3rd Party Instruments
● Formal Code Exchange agreements with major
manufacturers:
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Waters
Agilent
CTC
Shimadzu
● For other manufacturers we rely on openly published codes
● e.g. GSIOC codes for Gilson systems
● For some manufacturers we provide a Driver Development Kit
● Merck Hitachi
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SUMMARY
Chromeleon 7 – Simply Intelligent
• Contains the Intelligent Functionality needed to generate the result!
• Uses Operational Simplicity™ to minimize the steps and time needed to
generate the result!
• Offers state-of-the-art technology:
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User Interface with “Ribbon”
COBRA Peak Detection Algorithm & Wizard
SmartPeaks Integration Assistant
eWorkflows – THE framework for Operational Simplicity
Advanced Interactive Charting
Advanced Reporting
• Permits control of multiple vendors equipment from one application.
Chromeleon 7 – Simply Intelligent
Questions?