the Spring Bioscience Antibody Catalog.

Transcription

SPRING BIOSCIENCE TARGETED PRODUCTS FOR CANCER RESEARCH
2013 RESEARCH CATALOG
Spring Bioscience develops carefully
selected products that provide the
research community with strategic
antibody biomarkers for assessing
protein expression in tissue.
Spring’s expertise lies in the creation
of Rabbit Monoclonal Antibodies (SP
clones), complemented by advanced
detection and ancillary products used
in immunohistochemistry (IHC) and
other applications.
N-Ras (Q61R) (SP174)
SK-MEL-2 Cells
hENT1 (SP120)
Human Pancreas
SOX-2 (SP76)
Human Lung Carcinoma
PRIMARY ANTIBODIES
DETECTION SYSTEMS
RECOMBINANT PROTEINS
ANTIBODY MICROARRAYS
OTHER COMPLEMENTARY REAGENTS
ME SS AG E F R O M SPRI N G B I OSCI E NCE
Community of Cancer Researchers,
Thank you for using our 2013 catalog. Our mission is to build essential tools for cancer
researchers so that tomorrow’s patients may benefit from today’s innovations. Today, there are
very few of us who can say that their lives have not been touched by cancer. As part of Ventana
Medical Systems, and the greater Roche Group, we remain committed to providing researchers
with the tools needed for the analysis of cancer tissue.
Spring was founded in 2001 by a team of scientists and achieved early success with their line of
SP Clone rabbit monoclonal antibodies optimized for immunohistochemistry. This momentum
was quickly noticed by Ventana Medical Systems who acquired the company in 2007 for its
antibody development capabilities. Ventana Medical Systems was shortly thereafter acquired by
Roche.
Today Spring serves an important role as an antibody center of excellence in Roche’s mission
to deliver companion diagnostics. This is accomplished through not only developing antibodies
destined for clinical assays through Ventana and other Roche affiliates but using our collective
medical/market intelligence to serve the cancer research community.
Our 2013 catalog consists of the many new products we have launched during the past year.
This includes new mutation specific antibodies, as well as a broad selection of new recombinant
rabbit monoclonal antibodies. We are able to provide products and resources to end users, both
directly and via our distributor network.
We continue to add more content to our website, www.springbio.com. Throughout 2013, up to
date product information will be uploaded to include additional product images, protocols and
literature references, as well as highlighting new products and promotions.
Thank you for the opportunity to be a partner in your important research. If there is anything we
can do to better serve you, please let us know.
Sincerely,
y,
Megan Lehrkamp
Interim General Manager, Spring Bioscience
Table of Contents
Primary Antibody Products
13
Detection and Ancillary Products
117
Antibody Microarray Products
121
Recombinant Protein Products
123
Product Index
125
6
Urinary Bladder
Thyroid
Testis
Stomach
Soft Tissue
SM Intestine
Skin
Prostate
Pleura
Placenta
Pancreas
Ovary
Osseous Tissue
Nervous Tissue
Lung
Liver
Kidney
Hematopoietic Cells
Endocrine
Colorectum
Clone
Cervix
Product Name
Cardiovascular
Root
Cat#
Breast
Rabbit Monoclonal Antibodies by Tissue Focus
M424
Actin-beta
SP124
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M471
Actin-Smooth Muscle (SMA)
SP171
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
SMC
M308
ALK/p80
SP8
M454
Alpha-Fetoprotein (AFP)
SP154
M444
Anaplastic Lymphoma
Kinase (ALK)
SP144
√
√
√
CA
AL
√
√
CA
M407
Androgen Receptor (AR)
SP107
M456
Arginase-1
SP156
√
√
√
√
M347
BAX
SP47
√
√
√
√
√
√
M366
BCL-2 alpha
SP66
√
√
√
√
√
√
M392
BOB-1
SP92
M455
BCL-6
SP155
M453
BCL-10
SP153
M391
C4d
SP91
M483
Cadherin-17
SP183
M364
Cadherin-E/E-Cadherin
SP64
√
√
√
√
M390
Cadherin-N/N-Cadherin
SP90
√
√
√
√
M317
Calcitonin
SP17
M381
Calpain
SP81
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M382
Calpastatin
SP82
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M313
Calretinin
SP13
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M406
Carbonic Anhydrase 9
(CA-9)
SP106
M343
Caveolin-1
SP43
M457
CD1a
SP157
√
M307
CD3
SP7
TC
M462
CD3
SP162
M335
CD4
SP35
TC
M319
CD5
SP19
TC
M394
CD7
SP94
TC
M316
CD8
SP16
M367
CD10
SP67
√
√
√
√
√
√
√
√
M479
CD10
SP179
√
√
√
√
√
√
√
√
M459
CD15
SP159
√
M475
CD16a
SP175
√
M489
CD16a
SP189
√
M410
CD19
SP110
BC
M332
CD20
SP32
BC
M404
CD22
SP104
BC
M323
CD23
SP23
BC
M463
CD23
SP163
BC
M476
CD25
SP176
M338
CD31
SP38
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
M464
CD31
SP164
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
EC
M449
CD38
SP149
M355
CD43
SP55
M337
CD44 Std
SP37
√
√
√
√
√
√
M318
CD79a
SP18
M419
CD99
SP119
√
√
M326
CD117/c-kit
SP26
M452
CD138
SP152
M396
CD163
SP96
M398
CD278/ICOS
SP98
M380
CDK2
SP80
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
EC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
DC
√
√
√
√
√
√
√
√
√
√
√
√
√
TC
√
√
√
TC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
BC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
TC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√ Indicates the organs or tumors derived from these organs express these markers using the information available in the public domain.
Abbreviation: AL=Anaplastic Lymphoma, BC=B Lymphocyte, CA=Carcinoma, DC=Dendritic Cell, EC=Endothelial Cell, K=Kupffer Cells, M=Macrophages, MC=Cardiac, Skeletal, and Smooth
Muscle Cells, NE=Neuroendocrine Cell, PC=Plasma Cell, PLC=Proliferating Cell, PT=Parathyroid Gland, RBC=Red Blood Cell, SMC=Smooth Muscle Cell, ST=Stem Cell, TC=T Lymphocyte.
√
√
√
√
M401
c-erbB-2/HER-2
SP101
√
√
√
√
√
√
√
√
√
√
√
√
√
M371
c-erbB-3/HER-3
SP71
√
√
√
√
√
√
√
√
√
√
√
M312
Chromogranin A
SP12
NE
NE
NE
M428
Claudin-1
SP128
√
√
√
√
√
√
√
√
M344
c-Met
SP44
√
√
√
√
√
√
√
√
√
√
M359
c-Met (Paired 1003)
SP59
√
√
√
√
√
√
√
√
M358
c-Met (Phospho Y1003)
SP58
CA
M321
COX-2
SP21
√
M383
c-TEN
SP83
√
√
M304
Cyclin D1
SP4
PLC
PLC
M446
Cyclin E1
SP146
PLC
M438
Desmin
SP138
√
M331
DOG-1
SP31
M469
EphA2
SP169
CA
M309
Epidermal Growth Factor
Receptor (EGFR)
SP9
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M384
Receptor (EGFR)
SP84
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M368
ERCC1
SP68
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M301
Estrogen Receptor (ER)
SP1
√
M429
EZH2
SP129
√
√
M415
F4/80
SP115
M423
FLK-1 (mouse)
SP123
√
√
√
√
√
√
√
M434
Fn14
SP134
M388
FOXA1
SP88
√
√
√
√
√
√
√
M433
FOXP1
SP133
M397
FOXP3
SP97
M473
GIV
SP173
√
√
√
M458
GIV (pY1765)
SP158
√
√
√
M378
Glial Fibrillary Acidic
Protein (GFAP)
SP78
M468
GLUT-1
SP168
M386
Glypican-3
SP86
M420
hENT1
SP120
M408
IKAROS
SP108
M405
J-chain
SP105
M448
Kappa Light Chain
SP148
M327
Keratin 5
SP27
√
√
M478
Keratin 5
SP178
√
M387
Keratin 6
SP87
M352
Keratin 7
M402
M399
√
√
√
√
NE
√
√
NE
√
√
CA
CA
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
√
√
√
NE
√
NE
√
√
√
√
√
√
√
ca
ca
√
√
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
CA
√
√
√
√
NE
NE
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
ca
ca
√
√
√
√
√
√
√
ca
√
√
√
√
√
√
√
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
√
CA
√
√
√
√
√
√
PLC
PLC
√
√
√
CA
√
√
√
M
M
√
√
√
√
K
√
√
CA
√
√
√
√
CA
√
√
√
√
√
CA
√
√
√
CA
Urinary Bladder
SM Intestine
√
Thyroid
Skin
√
Testis
Prostate
√
√
Stomach
Pleura
√
Soft Tissue
Placenta
√
√
Pancreas
√
Ovary
√
Osseous Tissue
√
Nervous Tissue
√
Lung
√
Liver
Kidney
SP3
Endocrine
c-erbB-2/HER-2
Clone
Colorectum
SP54
M303
Product Name
Cervix
CDX2
Cardiovascular
M354
Root
Cat#
Breast
Hematopoietic Cells
√
√
√
√
M
√
√
M
M
√
√
CA
√
√
√
M
√
√
√
CA
√
√
√
√
√
√
√
√
CA
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
RBC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
SP52
√
√
√
√
√
√
√
√
√
√
√
√
√
√
Keratin 8
SP102
√
√
√
√
√
√
√
√
√
√
√
√
√
Keratin 10
SP99
√
√
√
√
√
√
√
√
M353
Keratin 14
SP53
√
√
√
√
√
√
M395
Keratin 17
SP95
√
√
√
M369
Keratin 18
SP69
√
√
√
√
M435
Keratin 18
SP135
√
√
√
√
M333
Keratin 20
SP33
√
√
M306
Ki-67
SP6
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
M430
Ku80
SP130
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M447
Lambda Light Chain
SP147
M351
LMO2
SP51
M432
Luteinizing Hormone (LH)
SP132
√
√
√
√
√
√
√
√
√
√
√
√
PC
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
PLC
PLC
PLC
PLC
PLC
PLC
√
√
√
√
√
√
√
√
√
√
√
√
√
7
8
√
√
√
√
√
√
√
√
√
√
√
√
√
M
M
Pancreas
√
√
Ovary
Osseous Tissue
√
√
√
√
√
√
√
Urinary Bladder
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M477
MAP4K4
SP177
M385
MCM2
SP85
√
M374
Mesothelin
SP74
√
M346
MSH2
SP46
M393
MSH6
SP93
M414
MUM1/IRF4
SP114
√
M372
Myeloperoxidase (MPO)
SP72
√
M437
Negative Control for
Rabbit IgG
SP137
M403
Nestin
SP103
M426
Nitric Oxide SynthaseInducible (iNOS)
SP126
M474
N-Ras (Q61R)
SP174
CA
M305
p53
SP5
√
M461
p53
SP161
M418
p57
SP118
M363
p120 (catenin delta 1)
SP63
M451
Parathyroid Hormone (PTH)
SP151
M334
PAX-5
SP34
M436
PCNA
SP136
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
PLC
M362
PI3K p85
SP62
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M439
pI3KCA
SP139
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M315
PLAP
SP15
M302
Progesterone Receptor (PR)
SP2
√
√
√
√
√
√
√
√
√
√
√
M342
SP42
√
√
√
√
√
√
√
√
√
√
√
M329
PSMA
SP29
M467
RRM1
SP167
M427
S100 beta
SP127
M350
S6 Ribosomal
(Phospho S235/236)
SP50
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M345
S6 Ribosomal
(Phospho S240/244)
SP45
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M422
SLIT2
SP122
M376
SOX-2
SP76
M466
Spink1
SP166
M349
Stathmin
SP49
√
√
√
√
√
√
√
√
√
√
√
√
√
M379
Survivin
SP79
√
√
√
√
√
√
√
√
√
√
√
√
√
M311
Synaptophysin
SP11
NE
NE
NE
NE
M336
Syntaxin 1A
SP36
M370
Tau (Neuronal Marker)
SP70
M450
Terminal Deoxynucleotidyl
Transferase (TdT)
SP150
M412
Thymidylate Synthase (TS)
SP112
M441
Thyroid Transcription
Factor-1 (TTF-1)
SP141
M373
Uroplakin III
SP73
M328
Vascular Endothelial
Growth Factor (VEGF)
SP28
M445
Villin
SP145
M320
Vimentin
M417
Vinculin
√
√
√
√
√
√
√
√
√
ST
M
ST
M
M
√
√
Thyroid
√
√
√
√
Testis
√
√
√
Stomach
√
Soft Tissue
√
√
SM Intestine
M
√
Skin
√
√
Prostate
√
√
Pleura
Lung
√
√
Placenta
Liver
√
√
Nervous Tissue
Hematopoietic Cells
√
Kidney
Endocrine
√
Colorectum
Clone
Cervix
Product Name
Cardiovascular
Root
Cat#
Breast
√
ST
M
CA
CA
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
PT
√
√
√
√
√
√
√
√
√
√
√
√
√
ST
ST
√
√
√
ST
ST
ST
ST
√
√
√
√
ST
√
√
√
√
√
√
√
√
√
ST
√
√
NE
√
√
ST
√
√
√
√
√
√
√
√
√
√
√
NE
NE
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
NE
√
√
ST
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
SP20
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
SP117
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
MC,
EC
√
√ Indicates the organs or tumors derived from these organs express these markers using the information available in the public domain.
Abbreviation: AL=Anaplastic Lymphoma, BC=B Lymphocyte, CA=Carcinoma, DC=Dendritic Cell, EC=Endothelial Cell, K=Kupffer Cells, M=Macrophages, MC=Cardiac, Skeletal, and Smooth
Muscle Cells, NE=Neuroendocrine Cell, PC=Plasma Cell, PLC=Proliferating Cell, PT=Parathyroid Gland, RBC=Red Blood Cell, SMC=Smooth Muscle Cell, ST=Stem Cell, TC=T Lymphocyte.
SP124
M308
ALK/p80
SP8
M454
Alpha-Fetoprotein (AFP)
SP154
M444
Anaplastic Lymphoma
Kinase (ALK)
SP144
Androgen Receptor (AR)
SP107
SP156
M347
BAX
SP47
√
M366
BCL-2 alpha
SP66
√
M392
BOB-1
SP92
M455
BCL-6
SP155
√
M453
BCL-10
SP153
√
M391
C4d
SP91
M483
Cadherin-17
SP183
Cadherin-E/E-Cadherin
SP64
SP90
M317
Calcitonin
SP17
M381
Calpain
SP81
M382
Calpastatin
SP82
√
√
√
√
√
√
√
Calretinin
SP13
SP106
M343
Caveolin-1
SP43
M457
CD1a
SP157
M307
CD3
SP7
√
M462
CD3
SP162
√
M335
CD4
SP35
√
M319
CD5
SP19
√
M394
CD7
SP94
M316
CD8
SP16
√
M367
CD10
SP67
√
M479
CD10
SP179
M459
CD15
SP159
√
√
√
√
√
√
√
M475
CD16a
SP175
M489
CD16a
SP189
M410
CD19
SP110
√
M332
CD20
SP32
√
M404
CD22
SP104
√
M323
CD23
SP23
√
M463
CD23
SP163
√
M476
CD25
SP176
M338
CD31
SP38
√
√
CD31
SP164
SP149
M355
CD43
SP55
M337
CD44 Std
SP37
M318
CD79a
SP18
M419
CD99
SP119
M326
CD117/c-kit
SP26
M452
CD138
SP152
M396
CD163
SP96
M398
CD278/ICOS
SP98
M380
CDK2
SP80
Translational Control
√
Carbonic Anhydrase 9
(CA-9)
CD38
Transcriptional Regulators
√
M313
M449
Synthesis and Degradation
√
M406
M464
Steroid Receptors
Stem Cell
Signal Transduction
Oncogenesis
Nitrogen Metabolism
Neuroscience
Muscle Markers
Metabolism
Lymphocyte Signaling
Immune Response
Immunoglobulin
Hormones
Homeodomain Proteins
Hematopoiesis
Enzymes
EGFR Family
DNA Synthesis
DNA Replication and Repai r
Cytoskeletal Proteins
Complement
Cell Junctions
Cell Cycle
√
√
Arginase-1
Cadherin-N/N-Cadherin
Cell Adhesion
√
M456
M390
Cancer Markers
√
M407
M364
B Cell Markers
Clone
Actin-beta
Apoptosis
Product Name
M424
Angiogenesis
Root
Cat#
AKT/PKB Signaling
Rabbit Monoclonal Antibodies by Research Interest
√
√
√
√
√
√
√
√
√
√
√
√
√
9
M354
CDX2
SP54
M303
c-erbB-2/HER-2
SP3
√
M401
c-erbB-2/HER-2
SP101
√
M371
c-erbB-3/HER-3
SP71
√
M312
Chromogranin A
SP12
M428
Claudin-1
SP128
M344
c-Met
SP44
√
M359
c-Met (Paired 1003)
SP59
√
M358
c-Met (phospho Y1003)
SP58
√
M321
COX-2
SP21
M383
c-TEN
SP83
Cyclin D1
SP4
√
SP146
√
M438
Desmin
SP138
M331
DOG-1
SP31
M469
EphA2
SP169
M309
Receptor (EGFR)
SP9
√
M384
Receptor (EGFR)
SP84
√
ERCC1
SP68
SP1
M429
EZH2
SP129
M415
F4/80
SP115
M423
FLK-1 (mouse)
SP123
M434
Fn14
SP134
M388
FOXA1
SP88
M433
FOXP1
SP133
√
√
√
√
√
√
√
√
√
√
FOXP3
SP97
M473
GIV
SP173
√
M458
GIV (pY1765)
SP158
√
M378
Glial Fibrillary Acidic
Protein (GFAP)
SP78
M468
GLUT-1
SP168
M386
Glypican-3
SP86
M420
hENT1
SP120
M408
IKAROS
SP108
M405
J-chain
SP105
M448
Kappa Light Chain
SP148
M327
Keratin 5
SP27
M478
Keratin 5
SP178
M387
Keratin 6
SP87
M352
Keratin 7
SP52
M402
Keratin 8
SP102
√
M399
Keratin 10
SP99
√
M353
Keratin 14
SP53
M395
Keratin 17
SP95
Keratin 18
SP69
M435
Keratin 18
SP135
M333
Keratin 20
SP33
M306
Ki-67
SP6
M430
Ku80
SP130
M447
Lambda Light Chain
SP147
10
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M397
M369
√
√
Cyclin E1
Estrogen Receptor (ER)
Steroid Receptors
√
√
M446
M301
Stem Cell
√
M304
M368
Signal Transduction
Oncogenesis
Nitrogen Metabolism
Neuroscience
Muscle Markers
Metabolism
Immune Response
Immunoglobulin
Hormones
Hematopoiesis
Enzymes
EGFR Family
DNA Synthesis
Complement
Cell Junctions
Cell Cycle
Cell Adhesion
Cancer Markers
B Cell Markers
Clone
Apoptosis
Product Name
Angiogenesis
Root
Cat#
AKT/PKB Signaling
SP51
M432
Luteinizing Hormone (LH)
SP132
Steroid Receptors
Stem Cell
Signal Transduction
Oncogenesis
Nitrogen Metabolism
Neuroscience
Muscle Markers
Metabolism
Immune Response
Immunoglobulin
Hormones
Hematopoiesis
Enzymes
EGFR Family
DNA Synthesis
Complement
Cell Junctions
Cell Cycle
Cell Adhesion
Cancer Markers
B Cell Markers
Clone
LMO2
Apoptosis
Product Name
M351
Angiogenesis
Root
Cat#
AKT/PKB Signaling
√
√
M477
MAP4K4
SP177
M385
MCM2
SP85
√
M374
Mesothelin
SP74
M346
MSH2
SP46
√
M393
MSH6
SP93
√
M414
MUM1/IRF4
SP114
M372
Myeloperoxidase (MPO)
SP72
M437
Negative Control for
Rabbit IgG
SP137
M403
Nestin
SP103
M426
Nitric Oxide SynthaseInducible (iNOS)
SP126
M474
N-Ras (Q61R)
SP174
M305
p53
SP5
√
M461
p53
SP161
√
M418
p57
SP118
M363
p120 (catenin delta 1)
SP63
M451
Parathyroid Hormone (PTH)
SP151
M334
PAX-5
SP34
M436
PCNA
SP136
M362
PI3k p85
SP62
M439
pI3KCA
SP139
M315
PLAP
SP15
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
M302
SP2
M342
SP42
M329
PSMA
SP29
M467
RRM1
SP167
M427
S100 beta
SP127
M350
S6 Ribosomal
(phospho S235/236)
SP50
√
M345
S6 Ribosomal
(phospho S240/244)
SP45
√
M422
SLIT2
SP122
M376
SOX-2
SP76
M466
Spink1
SP166
M349
Stathmin
SP49
M379
Survivin
SP79
M311
Synaptophysin
SP11
M336
Syntaxin 1A
SP36
√
M370
Tau (Neuronal Marker)
SP70
√
M450
Terminal Deoxynucleotidyl
Transferase (TdT)
SP150
M412
Thymidylate Synthase (TS)
SP112
M441
Thyroid Transcription
Factor-1 (TTF-1)
SP141
M373
Uroplakin III
SP73
M328
Vascular Endothelial
Growth Factor (VEGF)
SP28
M445
Villin
SP145
M320
Vimentin
SP20
M417
Vinculin
SP117
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
√
11
SP = Spring Proprietary
While you may not be familiar with Spring Bioscience Corporation, you are probably
quite familiar with rabbit monoclonal “SP” clones. All SP antibody clone products were
designed and manufactured by Spring Bioscience. It all started with SP1, the now gold
standard Estrogen Receptor marker. SP clones continue to emerge as best-in-class
immunohistochemistry markers for their high affinity, sensitivity, and specificity.
12
Terms and Conditions
Spring Bioscience products are for research use only. They are not for use in diagnostic procedures.
Spring Bioscience strives to provide complete and accurate information; however, Spring Bioscience and its business associates assume no liability for any reliance on any of the
information provided. Furthermore, Spring Bioscience assumes no liability for any omissions. It is the sole responsibility of researchers to independently validate the information and proper
use of any products. Spring Bioscience reserves the right to make any changes, additions, and/or deletions to its product information at anytime without notice.
PRIMARY ANTIBODY PRODUCTS
Spring Bioscience develops and
manufactures a wide range of products
primarily specialized for IHC and also
tested in other applications.
Primary Antibodies—specifically
optimized for use in IHC, featuring:
• Clean and intense staining
• Lower pre-treatment requirement
• Robust performance for FFPE tissue
• Improved reproducibility
• Accepted by industry leaders
Available in 0.1ml, 0.5ml and 1.0ml
concentrated sizes as well as a 7.0ml
Ready-to-Use configuration.
Antibody product technologies include:
• Rabbit Monoclonal (SP clones)
• Mouse Monoclonal (SPM clones)
• Rabbit Polyclonal
133
14-3-3 beta Rabbit Polyclonal
Actin-beta Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4550
0.1ml
Concentrate
Immunogen: N-terminus of human beta actin.
Concentrate
Immunogen: Synthetic peptide from
N-terminus of human 14-3-3 beta.
E4552
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P, WB
E4554
1.0ml
Concentrate
Species Reactivity*: Human
7.0ml
Ready-to-Use
E4551
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2920
0.1ml
Concentrate
E2922
0.5ml
E2924
E2921
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Leiomyoma, Skin
Control Tissue: Brain, Prostate
Carcinoma, Liver Carcinoma
Cellular Localization: Cytoplasm, Membrane
Cellular Localization: Cytoplasm
Control Lysate: Jurkat
Molecular Weight: 30 kDa
Human leiomyoma stained with
anti-actin-beta antibody E455
Human brain stained with
anti-14-3-3 beta antibody E292
Product Narrative: At least 7 mammalian isoforms comprise the 14-3-3 family of
signaling intermediates. 14-3-3 molecules are highly conserved, expressed in a broad
range of tissues and cell types and were first discovered as a series of highly abundant
proteins in brain tissue. There is increasing evidence that 14-3-3 proteins are critical to
cell transformation and mitotic signaling.
Product Narrative: The two major cytoskeletal proteins implicated in cell motility are
actin and myosin. There are three α-actins (skeletal, cardiac, and smooth muscle), one
β-actin (β-nonmuscle), and two γ-actins (γ-smooth muscle and γ-nonmuscle). Antibody
to β-actin provides a specific and useful tool in studying the intracellular distribution of
β-actin and the static and dynamic aspects of the cytoskeleton.
14-3-3 zeta Rabbit Polyclonal
Actin-Skeletal Muscle Mouse Monoclonal
Clone: 5C5.F8.C7
Clone: N/A
Catalog No.
Size
Format
E16650
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived
from internal region of human 14-3-3 zeta.
E16652
0.5ml
Concentrate
Immunogen: N-terminus decapeptide of alpha skeletal
muscle isoform of actin.
E16654
1.0ml
Concentrate
Application: IHC-P
E16651
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12600
0.1ml
Concentrate
E12602
0.5ml
E12604
1.0ml
Concentrate
E12601
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Mouse IgM
Control Tissue: Breast Carcinoma, Tonsil
Control Tissue: Skeletal Muscle
Control Lysate: 293T
Human skeletal muscle stained with
anti-actin antibody E1665
Human breast carcinoma stained with
anti-14-3-3 zeta antibody E1260
Product Narrative: 14-3-3 proteins regulate many cellular processes relevant to
cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints.
14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic
sequestration, occupation of interaction domains and import/export sequences,
prevention of degradation and activation/repression of enzyme activity.
Product Narrative: This antibody reacts with sarcomeric actins of normal tissues and
neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
Actin-beta Rabbit Monoclonal
Actin-Skeletal Muscle Rabbit Polyclonal
Clone: SP124
Catalog No.
Size
Format
E3880
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the
N-terminus of human actin-beta protein.
E3882
0.5ml
Concentrate
E3884
1.0ml
Concentrate
E3881
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4240
0.1ml
Concentrate
M4242
0.5ml
M4244
1.0ml
Concentrate
M4241
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Synthetic peptide derived from
N-terminus of human alpha skeletal muscle isoform
of actin.
Application: IHC-P
Isotype: Rabbit IgG
Control Tissue: Placenta
Isotype: Rabbit IgG
Control Lysate: Raji
Human placenta stained with
anti-actin-beta antibody M424
Product Narrative: Beta-actin is a nonmuscle cytoskeletal protein in all human cell
types and is involved in cell motility, structure, and integrity. There are six different actin
isoforms in human. Antibody to beta-actin provides a specific and useful tool in studying
the intracellular distribution of beta-actin and the static and dynamic aspects of the
cytoskeleton.
14
Product Narrative: This antibody reacts with sarcomeric actins of normal tissues and
neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting
*Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details.
**Product available to direct customers and Spring-appointed distributors only.
Primary Antibodies
Actin-Smooth Muscle Mouse Monoclonal
Adenomatous Polyposis Coli (APC) Rabbit Polyclonal
Clone: 1A4
Catalog No.
Size
Format
E4080
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus of
human alpha smooth muscle isoform of actin.
E4082
0.5ml
Concentrate
C-terminus of human APC protein.
Application: IHC-P
E4084
1.0ml
Concentrate
Application: IHC-P
E4081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14340
0.1ml
Concentrate
E14342
0.5ml
E14344
1.0ml
Concentrate
E14341
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Mouse IgG1/k
Isotype: Rabbit IgG
Control Tissue: Leiomyoma, Smooth Muscle
Control Tissue: Colon, Colon Carcinoma
Human small intestine stained with
Human colon carcinoma stained with
anti-APC antibody E408
Product Narrative: This antibody stains smooth muscle cells in vessel walls, gut wall, and
myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts
with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts
(beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium
(alpha-myocardial) are not stained.
Product Narrative: APC is associated with structural components of intracellular
junctions, including conductin, and it competes with E-cadherin for binding to specific
internal regions of both β- and γ-catenin. Like APC, APC2 contains SAMP domains, which
are required for conductin binding. Both APC and APC2 regulate the formation of active
β-catenin-Tcf complexes.
Actin-Smooth Muscle Rabbit Polyclonal
Adrenocorticotrophic Hormone (ACTH) Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E16450
0.1ml
Concentrate
Immunogen: ACTH synthetic peptide.
Concentrate
human alpha smooth muscle isoform of actin.
E16452
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E16454
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16451
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2460
0.1ml
Concentrate
E2462
0.5ml
E2464
E2461
Clone: SPM501
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: Pituitary
Control Tissue: Leiomyoma, Smooth Muscle
anti-actin smooth muscle antibody E246
Human pituitary stained with
anti-ACTH antibody E1645
Product Narrative: This antibody stains smooth muscle cells in vessel walls, gut wall, and
myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts
with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts
(beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium
(alpha-myocardial) are not stained.
Product Narrative: ACTH labels corticotrophs in the adenohypophysis and is useful in
the classification of pituitary adenomas.
Actin-Smooth Muscle (SMA) Rabbit Monoclonal
Adrenocorticotrophic Hormone (ACTH) Rabbit Polyclonal
Clone: SP171
Catalog No.
Size
Format
E3490
0.1ml
Concentrate
Concentrate
N-terminus of human SMA protein.
E3492
0.5ml
Concentrate
N-terminus of human ACTH.
E3494
1.0ml
Concentrate
Application: IHC-P
E3491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4710
0.1ml
Concentrate
M4712
0.5ml
M4714
1.0ml
Concentrate
M4711
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon
Control Lysate: HeLa Cell Lysate
Human colon stained with
anti-SMA antibody M471
Product Narrative: Smooth muscle actin-alpha (SMA) is a cytoskeleton protein in
smooth muscle cells and their derived tumors such as leiomyoma and leiomyosarcoma.
It is also expressed in myoepithelial cells of the breast and salivary gland, but not in
fibroblasts, striated muscle, and myocardium.
anti-ACTH antibody E349
Product Narrative: ACTH labels corticotrophs in the adenohypophysis and is useful in
the classification of pituitary adenomas.
US ORDERS Online: www.springbio.com Email: [email protected] Tel: +1.925.474.8440 Fax: +1.925.474.8469
INTERNATIONAL ORDERS Email: [email protected]
15
AKT-1/AKT-2 Rabbit Polyclonal
ALK/p80 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E1090
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from N-terminus
of human AKT-1.
E1092
0.5ml
Concentrate
Application: IHC-P
E1094
1.0ml
Concentrate
E1091
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10840
0.1ml
Concentrate
E10842
0.5ml
E10844
1.0ml
Concentrate
E10841
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Recombinant protein corresponding to a
region which spans the tyrosine kinase catalytic domain
and part of the C- terminus of the NPM-ALK transcript.
Application: IHC-P
Isotype: Rabbit IgG
Control Tissue: Lung Carcinoma
Isotype: Rabbit IgG
Control Tissue: Anaplastic Lymphoma
Cellular Localization: Cytoplasm, Nucleus
Human lung carcinoma stained with
anti-Akt 1/2 antibody E1084
Human anaplastic lymphoma stained with
anti-ALK antibody E109
Product Narrative: Two serine/threonine kinases, designated AKT-1 and AKT-2
(alternatively referred to as PKB or RacPK), exhibit sequence homology with the protein
kinase A and C families and are encoded by the c-AKT proto-oncogene. AKT-1 and AKT-2
contain a Pleckstrin homology (PH) domain and are activated by PDGF stimulation. This
activation is dependent on PDGFR-beta tyrosine residues 740 and 751, which bind the
85kDa subunit of the phosphatidylinositol 3-kinase (PI-3 kinase) complex.
Product Narrative: This antibody recognizes a human p80 protein, identified as a hybrid
of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene
resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas.
This antibody can be used to detect p80 in these lymphomas and may also be used to
detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.
AKT-1/PKB (Phospho S473) Rabbit Polyclonal
Alpha-Fetoprotein (AFP) Rabbit Monoclonal
Catalog No.
Size
Format
E13450
0.1ml
Concentrate
E13452
0.5ml
Concentrate
E13454
1.0ml
Concentrate
E13451
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide derived from the
region of human AKT-1 that contains phosphorylated
site of serine 473.
M4540
0.1ml
Concentrate
Immunogen: Purified human AFP
M4542
0.5ml
Concentrate
M4544
1.0ml
Concentrate
Application: IHC-P
M4541
7.0ml
Ready-to-Use
Clone: SP154
Isotype: Rabbit IgG
Control Tissue: Hepatocellular Carcinoma
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma
Control Lysate: HepG2 Cell Lysate
anti-AKT-1 antibody E1345
Human hepatocellular carcinoma stained with
anti-AFP antibody M454
Product Narrative: The AKT-1 serine threonine protein kinase is catalytically inactive
in serum starved primary and immortalized fibroblasts and activated by platelet
derived growth factor. The activation is rapid and specific. Survival factors can suppress
apoptosis in a transcription independent manner by activating AKT-1, which then
phosphorylates and inactivates components of the apoptotic machinery. This antibody
is specific to the phosphorylated form of AKT-1.
Product Narrative: AFP is normally synthesized in fetal liver, intestinal tract, and yolk sac.
High level of serum AFP has been identified in patients with hepatocellular carcinomas
(HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
ALK/p80 Rabbit Monoclonal
Alpha-Fetoprotein (AFP) Rabbit Polyclonal
Catalog No.
Size
Format
M3080
0.1ml
Concentrate
M3082
0.5ml
Concentrate
M3084
1.0ml
Concentrate
M3081
7.0ml
Ready-to-Use
Clone: SP8
Catalog No.
Size
Format
Immunogen: Recombinant protein corresponding to a
region which spans the tyrosine kinase catalytic domain
and part of the C-terminus of the NPM-ALK transcript.
E2950
0.1ml
Concentrate
Clone: N/A
E2952
0.5ml
Concentrate
Immunogen: Human alpha-fetoprotein
purified from human cord serum.
E2954
1.0ml
Concentrate
Application: IHC-P
E2951
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Fetal Liver, Hepatocellular
Carcinoma
anti-ALK antibody M308
Product Narrative: This antibody recognizes a human p80 protein, identified as a hybrid
of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene
resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas.
This antibody can be used to detect p80 in these lymphomas and may also be used to
detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.
16
Human fetal liver stained with
anti-AFP antibody E295
Product Narrative: AFP is normally synthesized in the liver, intestinal tract, and yolk sac
of the fetus. Antibody to AFP has been identified in hepatocellular carcinomas (HCC) and
germ cell neoplasms, especially yolk sac tumors.
Primary Antibodies
alpha-1-Antichymotrypsin Rabbit Polyclonal
Amyloid Precursor Protein (APP) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human alpha-1-antichymotrypsin.
E2650
0.1ml
Concentrate
Concentrate
Application: IHC-P
E2652
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to
N-terminus of human APP.
E2654
1.0ml
Concentrate
Application: IHC-P
E2651
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3450
0.1ml
E3452
0.5ml
E3454
1.0ml
Concentrate
E3451
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Control Tissue: Tonsil
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain
Cellular Localization: Cytoplasm, Extracellular Matrix
Human tonsil stained with
anti-ACT antibody E345
Human Alzheimer’s brain stained with
anti-APP antibody E265
Product Narrative: Alpha-1-Antichymotrypsin (Alpha 1-ACT) is an early-stage acutephase plasma protein and a serpin that preferentially inactivates chymotrypsin,
cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated
with amyloid plaques in Alzheimer’s disease (AD) and in normal aged human and
monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an
important role in neuromuscular differentiation.
Product Narrative: This antibody recognizes APP (β-APP770), MW 110kDa. Predicted
to recognize β-APP695 and β-APP751. Amyloid precursor protein (APP) and APP-like
proteins are transmembrane glycoproteins with a similar modular domain structure.
alpha-1-Antitrypsin Rabbit Polyclonal
Amyloid-beta/Amyloid A4 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human alpha-1-antitrypsin.
E3530
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3532
0.5ml
Concentrate
human amyloid beta.
E3534
1.0ml
Concentrate
Application: IHC-P
E3531
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3440
0.1ml
E3442
0.5ml
E3444
1.0ml
Concentrate
E3441
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Isotype: Rabbit IgG
Cellular Localization: Transmembrane,
Extracellular Matrix
anti-alpha-1-antitrypsin antibody E344
anti-amyloid β antibody E353
Product Narrative: Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic
variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it
acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase,
leucocytic proteases, plasmin, and thrombin. In the absence of alpha-1-AT, these
enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT
deficiency is associated with chronic obstructive lung disease (emphysema).
Product Narrative: Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived
from the amyloid betaprecursor protein. Beta amyloid is an extracellular filamentous
protein component of amyloid cores, neuritic plaques and is also found as a deposit in
neurofibrillary tangles in Alzheimer’s brain. Beta amyloid deposits are also detected
in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam
Parkinson-Dementia complex.
Amylin Peptide Rabbit Polyclonal
Anaplastic Lymphoma Kinase (ALK)** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4440
0.1ml
Concentrate
Concentrate
N-terminus of human amylin protein.
M4442
0.5ml
Concentrate
Application: IHC-P
M4444
1.0ml
Concentrate
M4441
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3400
0.1ml
Concentrate
E3402
0.5ml
E3404
1.0ml
Concentrate
E3401
7.0ml
Ready-to-Use
Clone: SP144
from the internal region of human ALK
protein.
Isotype: Rabbit IgG
Control Tissue: Pancreas
Isotype: Rabbit IgG
Control Lysate: Karpas Cell Lysate
Molecular Weight: 80 kDa, 88 kDa, 200 kDa
Human pancreas stained with
anti-amylin peptide antibody E340
Product Narrative: Amylin is a pancreatic islet peptide with a role in the maintenance of
glucose homoeostasis. It is predominantly found in the beta cells of the pancreas and to
a lesser extent in the gastrointestinal tract and nervous system. This antibody may prove
of value in studies to determine the level of staining for amylin in normal and diabetic
pancreas and pancreatic carcinoma.
anti-ALK antibody M444
Product Narrative: Anaplastic lymphoma kinase is a receptor tyrosine kinase.
Chromosomal translocations involving ALK have been found to be associated with
different diseases such as anaplastic large cell lymphomas (ALCLs) and non smallcell lung cancer (NSCLC). The constitutively active fusion proteins are responsible for
most of anaplastic large cell non-Hodgkin’s lymphomas. The EML4-ALK fusion gene is
responsible for approximately 3-5% of NSCLC.
17
Androgen Receptor (AR) Rabbit Monoclonal
Annexin VI Rabbit Polyclonal
Clone: SP107
Catalog No.
Size
Format
E12380
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide derived from near
N-terminus of human AR.
E12382
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding
to N-terminus of human Annexin VI.
Application: IHC-P
E12384
1.0ml
Concentrate
E12381
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4070
0.1ml
Concentrate
M4072
0.5ml
M4074
1.0ml
Concentrate
M4071
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Carcinoma
Control Tissue: Liver, Tonsil
Cellular Localization: Nucleus
Cellular Localization: Membrane
Human prostate carcinoma stained with
anti-AR- antibody M407
Human liver stained with
anti-Annexin VI antibody E1238
Product Narrative: The androgen receptor (AR) is a member of the steroid superfamily
of ligand-dependent transcription factors. The expression of AR is reportedly inversely
correlated with histologic grade, i.e., well differentiated prostate tumors show higher
expression than the poorly differentiated tumors.
Product Narrative: Annexin family members have been implicated as regulators of such
diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin
VI is positively regulated by calcium. It contains 8 annexin repeats and it binds actin
filament and lipids. Annexin VI has been localized to stress fibers, membrane ruffles, and
microspikes.
Androgen Receptor (AR) Rabbit Polyclonal
Apoptosis Protease Activating Factor 1 (APAF-1) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3950
0.1ml
Concentrate
Concentrate
from near N-terminus of human AR.
E3952
0.5ml
Concentrate
C-terminus of human APAF-1.
E3954
1.0ml
Concentrate
Application: IHC-P
E3951
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2720
0.1ml
Concentrate
E2722
0.5ml
E2724
1.0ml
Concentrate
E2721
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Testis
Control Lysate: LNCaP Cell Lysate
anti-AR antibody E272
Human testis stained with
anti-Apaf-1 antibody E395
Product Narrative: The androgen receptor (AR) is a member of the steroid superfamily
of ligand-dependent transcription factors. The expression of AR is reportedly inversely
correlated with histologic grade, i.e., well differentiated prostate tumors show higher
expression than the poorly differentiated tumors.
Product Narrative: APAF-1 is a cytosolic protein that rests in a latent state until bound
by cytochrome c (APAF-2). The resulting APAF-1/cytochrome c complex associates with
the zymogen form of caspase-9 (APAF-3) in the presence of dATP or ATP, promoting the
autocatalytic activation of caspase-9. This antibody can be useful in studies of apoptotic
cell death.
Annexin I Rabbit Polyclonal
Arginase-1** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4560
0.1ml
Concentrate
Concentrate
N-terminus of human annexin I.
M4562
0.5ml
Concentrate
C-terminus of human arginase-1 protein.
Application: IHC-P
M4564
1.0ml
Concentrate
Application: IHC-P
M4561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14030
0.1ml
Concentrate
E14032
0.5ml
E14034
1.0ml
Concentrate
E14031
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hepatocellular Carcinoma, Liver
anti-annexin A1 antibodyy E1403
anti-arginase-1 antibody M456
Product Narrative: Annexin family members have been implicated as regulators of such
diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin
A1, a gene related to phagocytosis, was found to be one of the most highly upregulated
genes in hairy cell leukemia.
18
Clone: SP156
Product Narative: Arginase-1 (ARG1) catalyzes the hydrolysis of L-arginine into ornithine
and urea, a critical step for the urea cycle. Defects in ARG1 are the cause of argininemia,
an autosomal recessive disorder characterized by hyperammonemia. There are several
isoforms of mammalian arginase. The type I isoform, is a cytosolic enzyme and expressed
predominantly in the liver as a component of the urea cycle. Hepatocellular carcinoma
usually shows higher protein expression of ARG1 than normal liver cells.
Primary Antibodies
Arginase-1 Rabbit Polyclonal
Catalog No.
Size
Format
E19280
0.1ml
Concentrate
E19282
0.5ml
Concentrate
E19284
1.0ml
Concentrate
E19281
7.0ml
Ready-to-Use
BAX Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
from the N-terminus of human arginase-1
protein.
E17990
0.1ml
Concentrate
Clone: N/A
E17992
0.5ml
Concentrate
Immunogen: Synthetic peptide derived from internal
region of human BAX protein.
E17994
1.0ml
Concentrate
Application: IHC-P
E17991
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit Ig G
Control Tissue: Breast, Colon
Control Tissue: Hepatocellular Carcinoma
(mild)
Control Lysate: MOLT-4 Cell Lysate
Human normal breast stained with
anti-BAX antibody E1799
anti-arginase-1 antibody E1928
Product Narative: Arginase-1 (ARG1) catalyzes the hydrolysis of L-arginine into ornithine
and urea, a critical step for the urea cycle. Defects in ARG1 are the cause of argininemia,
an autosomal recessive disorder characterized by hyperammonemia. There are several
isoforms of mammalian arginase. The type I isoform, is a cytosolic enzyme and expressed
predominantly in the liver as a component of the urea cycle. Hepatocellular carcinoma
usually shows higher protein expression of ARG1 than normal liver cells.
Product Narrative: BAX is a member of the BCL-2 family of proteins, which function as
regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can
form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
BCL-2 alpha** Rabbit Monoclonal
BAK Rabbit Polyclonal
Clone: SP66
Catalog No.
Size
Format
Clone: N/A
M3660
0.1ml
Concentrate
M3662
0.5ml
Concentrate
N-terminus of human BCL-2 alpha protein.
Concentrate
N-terminus of human BAK.
M3664
1.0ml
Concentrate
Application: IHC-P
Concentrate
Application: IHC-P
M3661
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3320
0.1ml
Concentrate
E3322
0.5ml
E3324
1.0ml
E3321
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-Bcl-2α antibody M366
anti-Bak antibody E332
Product Narrative: BAK or BCL-2-homologous antagonist is a member of the BCL-2
family of homologous proteins which function in the regulation of apoptosis. The
BCL-2 related proteins interact with one another through the formation of homo- and
heterodimers. BAK has been localized by immunohistochemistry to the cytosol of cells
and stains in a punctate pattern characteristic of other BCL-2 family proteins, which have
been localized to intracellular organelles.
Product Narrative: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell
death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express
high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers
are negative.
BCL-2 alpha Rabbit Polyclonal
BAX Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
Clone: SP47
E17980
0.1ml
Concentrate
E17982
0.5ml
Concentrate
N-terminus of human BCL-2 alpha protein.
Concentrate
internal region of human BAX protein.
E17984
1.0ml
Concentrate
Application: IHC-P
Concentrate
Application: IHC-P
E17981
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3470
0.1ml
Concentrate
M3472
0.5ml
M3474
1.0ml
M3471
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Colon
anti-BCL-2 alpha antibody E1798
Human normal breast stained with
anti-Bax antibody M347
Product Narrative: BAX is a member of the BCL-2 family of proteins, which function as
regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can
form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Product Narrative: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell
death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express
high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers
are negative.
19
BCL-6** Rabbit Monoclonal
BCL-10 Mouse Monoclonal
Clone: SP155
Catalog No.
Size
Format
E16760
0.1ml
Concentrate
Immunogen: Recombinant BCL-10 protein.
Concentrate
C-terminus of human BCL-6 protein.
E16762
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E16764
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16761
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4550
0.1ml
Concentrate
M4552
0.5ml
M4554
M4551
Clone:t SPM520
Isotype: Mouse IgG1
Isotype: Rabbit IgG
anti-BCL-6 antibody M455
anti-BCL-10 antibody E1676
Product Narrative: B cell lymphoma 6 protein (BCL-6) proto-oncogene product is mainly
expressed in normal germinal center B cells and related lymphomas. BCL-6 is involved
in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and BCL-6
rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas.
BCL-6 has been detected immunohistochemically in follicular lymphomas, diffuse large
B cell lymphomas, Burkitt lymphomas and in nodular, lymphocyte predominant
Hodgkin’s disease.
Product Narrative: BCL-10/CIPER/CLAP/mE10 is expressed in many human and
murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved
in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine
herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB.
Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in
pathogenesis of human cancer.
BCL-6 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E19030
0.1ml
Concentrate
Concentrate
internal region of human BCL-6 protein.
E19032
0.5ml
Concentrate
internal region of human BCL-10.
Application: IHC-P
E19034
1.0ml
Concentrate
Application: IHC-P
E19031
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14090
0.1ml
Concentrate
E14092
0.5ml
E14094
1.0ml
Concentrate
E14091
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-BCL-6 antibodyE1409
Product Narrative: BCL-6 proto-oncogene product is mainly expressed in normal
germinal center B cells and related lymphomas. BCL-6 is involved in chromosome
rearrangements at 3q27 in non-Hodgkin’s lymphomas and BCL-6 rearrangements
have been detected in diffuse large B cell lymphomas. BCL-6 has been detected
immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt
lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease.
Product Narrative: BCL-10/CIPER/CLAP/mE10 is expressed in many human and
murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved
in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine
herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB.
Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in
pathogenesis of human cancer.
BCL-10 Rabbit Monoclonal
Clone: SP153
Catalog No.
Size
Format
E19240
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide in the internal region of
the human BCL-10.
E19242
0.5ml
Concentrate
Immunogen: Synthetic peptide near the N-terminus of
human BCL-10 protein.
Application: IHC-P
E19244
1.0ml
Concentrate
Application: IHC-P
E19241
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4530
0.1ml
Concentrate
M4532
0.5ml
M4534
1.0ml
Concentrate
M4531
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: MALT B Cell Lymphoma, Tonsil
Human MALT B cell lymphoma stained with
anti-BCL-10 antibody M453
Product Narrative: BCL-10 is expressed at different evel in the cytoplasm of most normal
human cells and translocates into the nucleus in MALT lymphoma, especially in those
with translocation (1; 14)(p22;q32). BCL-10 and MALT-1 protein form a complex in MALT
lymphoma and are thought to synergize in the activation of NF-kappaB. BCL-10 contains
a caspase-recruiting (CARD) domain and is involved in activation of caspase-9 to induce
apoptosis. Mutations in BCL-10 are observed in some B and T cell lymphomas.
20
Clone: N/A
Product Narrative: BCL-10 is a cytoplasmic protein expressed at different levels in most
normal human cells and translocates into the nucleus of MALT lymphoma, especially in
those with translocation (1;14)(p22;q32). BCL-10 and MALT-1 protein form a complex in
MALT lymphoma. They are thought to synergize in the activation of NF-kappaB, and may
contribute to the same pathogenic process that leads to malignancy. Mutations in BCL10 are observed in some B and T cell lymphomas.
Primary Antibodies
BCL-X Rabbit Polyclonal
BIM/BOD Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4360
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic protein derived from
near N-terminus of the human BCL-X protein.
E4362
0.5ml
Concentrate
N-terminus of human BIM.
E4364
1.0ml
Concentrate
Application: IHC-P
E4361
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3370
0.1ml
Concentrate
E3372
0.5ml
E3374
1.0ml
Concentrate
E3371
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma
Cellular Localization: Cytoplasm,
Membrane, Nucleus
anti-Bim antibody E436
Human Hodgkin’s lymphoma stained with
anti-BCL-X antibody E337
Product Narrative: BCL-X is a member of the BCL-2 family of proteins, which function as
regulators of apoptosis. BCL-X has two isoforms, BCL-XL (long) a 241 amino acid protein
and BCL-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well
conserved among members of the BCL-2 family.
Product Narrative: BIM/BOD (BCL-2-related Ovarian Death Gene) belongs to BCL-2
family of proteins containing BCL-2 homology domain3 (BH3). It is proapoptotic and
exerts its effects by interacting with prosurvival members of the BCL-2 family like BCL-2,
BCL-XL and BCL-W. It exhibits three splice variants; BIML, BIMS and BIMEL. They all share
homology in their C-terminus BH3 domain and are ubiquitously expressed. BIMS is the
strongest of them with respect to the proapoptotic capacity.
BCL-XL Mouse Monoclonal
Bnip3L Rabbit Polyclonal
Clone: 7D9
Catalog No.
Size
Format
E16840
0.1ml
Concentrate
Concentrate
N-terminus of mouse BCL-XL protein.
E16842
0.5ml
Concentrate
internal region of human BNIP3L protein.
Application: IHC-P
E16844
1.0ml
Concentrate
Application: IHC-P
E16841
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16660
0.1ml
Concentrate
E16662
0.5ml
E16664
1.0ml
Concentrate
E16661
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Mouse IgG2a
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm, Membrane, Nucleus
anti-BCL-XL antibody E1666
anti-human Bnip3L antibody E1684
Product Narrative: BCL2/adenovirus E1B 19kDa protein-interacting protein 3-like
(Bnip3L) is a protein encoded by the BNIP3L gene in humans. Overexpression of Bnip3L
induces apoptosis. Bnip3L interacts with and overcomes suppression by BCL-2 and BCLXL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously
expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins.
BCL-XL Rabbit Polyclonal
BOB-1 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3920
0.1ml
Concentrate
Concentrate
N-terminus of human BCL-X protein.
M3922
0.5ml
Concentrate
to C-terminus of human BOB-1 protein.
M3924
1.0ml
Concentrate
M3921
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4200
0.1ml
Concentrate
E4202
0.5ml
E4204
1.0ml
Concentrate
E4201
7.0ml
Ready-to-Use
Clone: SP92
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma,
Hodgkin’s Lymphoma
Membrane, Nucleus
Control Lysate: Ramos
anti-Bob-1 antibody M392
anti-BCL-XL antibody E420
Product Narrative: B cell Oct binding protein 1 (BOB-1), is a transcription factor that
is required for germinal center formation and immunoglobulin production. BOB-1 is
expressed at high levels in spleen and peripheral blood leukocytes and represents an
OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.
21
BOB-1 Rabbit Polyclonal
BRAF V600E** Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E19290
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus
of human BOB-1.
E19292
0.5ml
Concentrate
E19294
1.0ml
Concentrate
N/A
N/A
N/A
Catalog No.
Size
Format
E16670
0.1ml
Concentrate
E16672
0.5ml
E16674
1.0ml
Concentrate
E16671
7.0ml
Ready-to-Use
Clone: VE1
Immunogen: Synthetic peptide representing the BRAF
V600E mutated amino acid sequence from amino acid
596 to 606 (GLATEKSRWSG).
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma with
BRAF V600E mutation
Control Lysate: N/A
anti-BOB-1 antibody E1667
Product Narrative: B cell Oct binding protein 1 (BOB-1), is a transcription factor that
is required for germinal center formation and immunoglobulin production. BOB-1 is
expressed at high levels in spleen and peripheral blood leukocytes and represents an
OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.
Bone Morphogenetic Protein 4 (BMP-4) Rabbit Polyclonal
Human colon carcinoma with V600E mutation stained with
anti-BRAF V600E antibody E1929
Product Narrative: Serine/threonine-protein kinase B-raf (BRAF) is a member of the Raf
family. BRAF V600E mutation accounts for the vast majority of BRAF alterations and the
mutation have been detected in melanoma, papillary thyroid carcinoma, pleomorphic
xanthoastrocytomas, Langerhans cell histiocytosis, borderline ovarian cancer,
ganglioglioma, colorectal carcinoma, and pilocytic astrocytoma.
Clone: N/A
C4d** Rabbit Monoclonal
Immunogen: Recombinant human BMP-4 protein.
Catalog No.
Size
Format
Application: IHC-P
M3910
0.1ml
Concentrate
M3912
0.5ml
Concentrate
C-terminus of human C4d protein.
Application: IHC-P
Catalog No.
Size
Format
E12510
0.1ml
Concentrate
E12512
0.5ml
Concentrate
E12514
1.0ml
Concentrate
E12511
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
M3914
1.0ml
Concentrate
M3911
7.0ml
Ready-to-Use
Control Tissue: Bone Marrow
Clone: SP91
Isotype: Rabbit IgG
Cellular Localization: Secreted Protein
Human bone marrow stained with
anti-BMP4 antibody E1251
Product Narrative: Bone morphogenetic protein 4 (BMP4) is one of nine structurally
related BMPs belonging to the transforming growth factor beta superfamily of secreted
proteins. BMP4 has important roles as a signaling molecule in the developing central
and peripheral nervous system, musculature and skeleton. BMP also plays an important
role in early tooth morphogenesis.
BRAF** Rat Monoclonal
Clone: pBR1
anti-C4d antibody M391
Product Narrative: C4 plays a central role in the activation of the classical pathway of
the complement system. Prior to secretion, the single-chain precursor is enzymatically
cleaved to yield the non-identical chains (alpha, beta and gamma). During activation,
the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and
gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and
C4d blocks the generation of C3 convertase.
C4d Rabbit Polyclonal
Catalog No.
Size
Format
E19300
0.1ml
Concentrate
Size
Format
0.5ml
Concentrate
Immunogen: Full length recombinant human
BRAF protein.
Catalog No.
E19302
E17340
0.1ml
Concentrate
Immunogen: Synthetic peptide of human C4d.
E19304
1.0ml
Concentrate
E17342
0.5ml
Concentrate
Application: IHC-P
E19301
7.0ml
Ready-to-Use
E17344
1.0ml
Concentrate
E17341
7.0ml
Ready-to-Use
Isotype: Rat IgG2a
Clone: N/A
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma
Control Tissue: Kidney, Tonsil
Cellular Localization: Secreted Protein
Control Lysate: N/A
anti-BRAF antibody E1930
Product Narrative: Serine/threonine-protein kinase B-raf (BRAF) is a member of the Raf
family. It participates in the transduction of mitogenic signals from the cell membrane
to the nucleus. BRAF mutations, especially BRAF V600E mutation, are frequent in benign
and malignant human tumors such as melanoma, papillary thyroid carcinoma, ovarian
cancer, and colorectal carcinoma.
22
anti-C4d antibody E1734
Product Narrative: C4 plays a central role in the activation of the classical pathway of
the complement system. Prior to secretion, the single-chain precursor is enzymatically
cleaved to yield the non-identical chains (alpha, beta and gamma). During activation,
the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and
gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and
C4d blocks the generation of C3 convertase.
Primary Antibodies
c-Abl Rabbit Polyclonal
Catalog No.
Size
Format
E4000
0.1ml
Concentrate
E4002
0.5ml
Concentrate
E4004
1.0ml
Concentrate
E4001
7.0ml
Ready-to-Use
Cadherin-E/E-Cadherin Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
Immunogen: Synthetic peptide from the sequence
adjacent to protein tyrosine kinase domain of
human c-Abl.
E8640
0.1ml
Concentrate
Clone: SPM471
E8642
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 600707 of human cadherin-E.
E8644
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E8641
7.0ml
Ready-to-Use
Isotype: Mouse IgG2b/k
Isotype: Rabbit IgG
Control Tissue: Breast, Skin, Tonsil
anti-c-Abl antibody E400
Human breast stained with
anti-cadherin-E/E-cadherin antibody E864
Product Narrative: The c-Abl proto-oncogene encodes a protein tyrosine kinase that
is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in
a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a
(9;22) chromosomal translocation producing a novel rearranged chromosome (the
Philadelphia chromosome). The molecular consequence of this translocation is the
generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Product Narrative: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell
adhesion molecule expressed predominately in epithelial tissues. It plays an important
role in the growth and development of cells via the mechanisms of control of tissue
architecture and the maintenance of tissue integrity.
Cadherin-17** Rabbit Monoclonal
Cadherin-E/E-Cadherin Rabbit Polyclonal
Clone: SP183
Catalog No.
Size
Format
E3460
0.1ml
Concentrate
Concentrate
C-terminus of human cadherin 17 protein.
E3462
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 600707 of human cadherin-E.
Application: IHC-P
E3464
1.0ml
Concentrate
Application: IHC-P
E3461
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4830
0.1ml
Concentrate
M4832
0.5ml
M4834
1.0ml
Concentrate
M4831
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Colon Adenocarcinoma
Control Tissue: Breast, Skin, Tonsil
Human colon adenocarcinoma stained with
anti-cadherin-17 antibody M483
Human skin stained with
anti-cadherin E/E-cadherin antibody E346
Product Narrative: Cadherin-17 (CDH17) is a calcium-dependent, membrane-associated
glycoprotein. It is consisted of an extracellular region with 7 cadherin domains and a
transmembrane region but lacking the conserved cytoplasmic domain. The protein
mainly distributes the gastrointestinal tract and pancreatic ducts. The protein is upregulated in various carcinomas of the digestive system.
Product Narrative: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell
adhesion molecule expressed predominately in epithelial tissues. It plays an important
role in the growth and development of cells via the mechanisms of control of tissue
architecture and the maintenance of tissue integrity.
Cadherin-E/E-Cadherin** Rabbit Monoclonal
Cadherin-N/N-Cadherin Rabbit Monoclonal
Clone: SP64
Catalog No.
Size
Format
M3900
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein
encoding aa 600-707 of human cadherin-E.
M3902
0.5ml
Concentrate
C-terminus of human cadherin-N protein.
M3904
1.0ml
Concentrate
Application: IHC-P
M3901
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3640
0.1ml
Concentrate
M3642
0.5ml
M3644
1.0ml
Concentrate
M3641
7.0ml
Ready-to-Use
Clone: SP90
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon
Control Tissue: Mesothelioma
Control Lysate: MCF7
Human breast ductal carcinoma stained with
anti-E-cadherin antibody M364
Product Narrative: Cadherin-E/E-cadherin (uvomorulin, cell-CAM120/80) is a calcium
dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays
an important role in the growth and development of cells via the mechanisms of control
of tissue architecture and the maintenance of tissue integrity.
Human mesothelioma stained with
anti-cadherin-N antibody M390
Product Narrative: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family
of transmembrane molecules that mediate calcium-dependent intercellular adhesion.
Cadherins are involved in controlling morphogenetic movements during development
and regulate cell surface adhesion. The function of N-cadherin is dependent on its
association with the actin-cytoskeleton and is mediated through interactions between
the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.
23
Cadherin-N/N-Cadherin Rabbit Polyclonal
Calcitonin Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3170
0.1ml
Concentrate
Concentrate
C-terminus of human cadherin-N protein.
M3172
0.5ml
Concentrate
Immunogen: Synthetic human calcitonin 1-32 amino
acid peptide.
Application: IHC-P
M3174
1.0ml
Concentrate
Application: IHC-P
M3171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18260
0.1ml
Concentrate
E18262
0.5ml
E18264
1.0ml
Concentrate
E18261
7.0ml
Ready-to-Use
Clone: SP17
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Adrenal Gland, Liver, Pancreas
Control Tissue: Thyroid, Thyroid Medullary Carcinoma
anti-cadherin-N/N-cadherin antibody E1826
Human thyroid medullary carcinoma stained with
anti-calcitonin antibody M317
Product Narrative: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family
of transmembrane molecules that mediate calcium-dependent intercellular adhesion.
Cadherins are involved in controlling morphogenetic movements during development
and regulate cell surface adhesion. The function of N-cadherin is dependent on its
association with the actin-cytoskeleton and is mediated through interactions between
the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.
Product Narrative: Calcitonin is a 32 amino acid peptide which can be demonstrated
in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum
of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors.
Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular
pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying
degrees of calcitonin activity.
Cadherin-pan Rabbit Polyclonal
Calcitonin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E1150
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of
chicken cadherin-N protein.
E1152
0.5ml
Concentrate
Immunogen: Synthetic human calcitonin
1-32 amino acid peptide.
Application: IHC-P
E1154
1.0ml
Concentrate
E1151
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2360
0.1ml
Concentrate
E2362
0.5ml
E2364
1.0ml
Concentrate
E2361
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin, Tonsil
Control Tissue: Thyroid, Thyroid Medullary
Carcinoma
Control Lysate: Human Thyroid
anti-cadherin (pan) antibody E236
Human thyroid stained with
anti-calcitonin antibody E115
Product Narrative: Cadherins are calcium dependent cell adhesion molecules, which
play important roles in the growth and development of cells via the mechanisms of
control of tissue architecture and the maintenance of tissue integrity. In adhesion
junctions, cadherins are bound to β and γ catenins, which in turn bind to α catenin, an
actin-binding protein. Cadherins play important roles in tumor invasion and metastasis.
Product Narrative: Calcitonin is a 32 amino acid peptide which can be demonstrated
in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum
of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors.
Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular
pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying
degrees of calcitonin activity.
Calbindin D28 Rabbit Polyclonal
Calcium Sensing Receptor (CaSR) Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E10620
0.1ml
Concentrate
Concentrate
C-terminus of human calbindin D28K protein.
E10622
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus of rat
calcium sensing receptor.
E10624
1.0ml
Concentrate
Application: IHC-P
E10621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10340
0.1ml
Concentrate
E10342
0.5ml
E10344
1.0ml
Concentrate
E10341
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Cerebellum, Kidney
Control Lysate: Human Kidney
Human cerebellum stained with
anti-calbindin D28 antibody E1034
Product Narrative: Calbindin-D-28K is a highly conserved calcium binding protein.
It belongs to a family of low molecular weight calcium-binding proteins (CaBPs).
Calbindin-D-28K is found predominantly in subpopulations of central and peripheral
nervous system neurons, and in certain epithelial nervous system neurons, and in
certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical
collecting tubules of the kidney, and in enteric neuroendocrine cells.
24
anti-CaSR antibody E1062
Product Narrative: The calcium sensing receptor (CaSR) has been shown to play a major
role in regulating parathyroid hormone secretion and subsequently influencing the
calcium concentration of extracellular fluids. Several disorders of calcium homeostasis
have been linked to mutations in the CaSR. These include familial hypocalciuric
hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal
dominant hypocalemia (ADHypo).
Primary Antibodies
Calpain Rabbit Monoclonal
Calpastatin Rabbit Polyclonal
Clone: SP81
Catalog No.
Size
Format
E18790
0.1ml
Concentrate
Concentrate
internal region of human calpain protein.
E18792
0.5ml
Concentrate
C-terminus of human calpastatin protein.
E18794
1.0ml
Concentrate
Application: IHC-P
Species Reactivity*: Human, Mouse
E18791
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3810
0.1ml
Concentrate
M3812
0.5ml
M3814
1.0ml
Concentrate
M3811
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-calpain antibody M381
anti-calpastatin antibody E1879
Product Narrative: Calpains are a ubiquitous, well-conserved family of calciumdependent, cysteine proteases. Calpain families have been implicated in
neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II
are heterodimeric with distinct large subunits associated with common small subunits,
all of which are encoded by different genes. Calpain S1 is a small subunit common to
both Calpain I and II and is associated with myotonic dystrophy.
Product Narrative: Calpastatin is an endogenous calpain (calcium-dependent cysteine
protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The
calpain/calpastatin system is involved in numerous membrane fusion events, such as
neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific
endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple
inhibitory fragments for calpain activity.
Calpain Rabbit Polyclonal
Calretinin Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3130
0.1ml
Concentrate
Concentrate
region of human calpain protein.
M3132
0.5ml
Concentrate
Immunogen: Recombinant full length mouse
calretinin protein.
Application: IHC-P
M3134
1.0ml
Concentrate
Application: IHC-P
M3131
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18780
0.1ml
Concentrate
E18782
0.5ml
E18784
1.0ml
Concentrate
E18781
7.0ml
Ready-to-Use
Clone: SP13
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Mesothelioma
Human breast ductal cell carcinoma stained with
anti-calpain antibody E1878
anti-calretinin antibody M313
Product Narrative: Calpains are a ubiquitous, well-conserved family of calciumdependent, cysteine proteases. Calpain families have been implicated in
neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II
are heterodimeric with distinct large subunits associated with common small subunits,
all of which are encoded by different genes. Calpain S1 is a small subunit common to
both Calpain I and II and is associated with myotonic dystrophy.
Product Narrative: Calretinin is an intracellular calcium-binding protein belonging to the
troponin C superfamily. The immunohistochemical detection of calretinin in developing
cerebellum is restricted to the later stages indicated by weak staining from week 21 of
gestation in Purkinje and basket cells and in neurons of the dentate nucleus. In tumors,
calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.
Calpastatin Rabbit Monoclonal
Calretinin Rabbit Polyclonal
Clone: SP82
Catalog No.
Size
Format
E1170
0.1ml
Concentrate
Concentrate
C-terminus of human calpastatin protein.
E1172
0.5ml
Concentrate
Immunogen: Recombinant full length mouse
calretinin protein.
Application: IHC-P
E1174
1.0ml
Concentrate
E1171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3820
0.1ml
Concentrate
M3822
0.5ml
M3824
1.0ml
Concentrate
M3821
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Mesothelioma
Control Lysate: Human Brain
anti-calpastatin antibody M382
Product Narrative: Calpastatin is an endogenous calpain (calcium-dependent cysteine
protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The
calpain/calpastatin system is involved in numerous membrane fusion events, such as
neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific
endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple
inhibitory fragments for calpain activity.
anti-calretinin antibody E117
Product Narrative: Calretinin is an intracellular calcium-binding protein belonging
to the troponin C superfamily. The immunohistochemical detection of calretinin in
developing cerebellum is restricted to the later stages indicated by weak staining from
week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus.
In tumors, calretinin has been detected in mesotheliomas and some pulmonary
adenocarcinomas.
25
CaM Kinase IV Rabbit Polyclonal
Carbonic Anhydrase 9 (CA-9) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18420
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from C-terminus of rat
CaM kinase IV.
E18422
0.5ml
Concentrate
from human CA-9.
Application: IHC-P
E18424
1.0ml
Concentrate
E18421
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10600
0.1ml
Concentrate
E10602
0.5ml
E10604
1.0ml
Concentrate
E10601
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain
Control Tissue: Stomach
Cellular Localization: Membrane, Nucleus
anti-CaM Kinase IV antibody E1060
Human stomach stained with
anti-CA-9 antibody E1842
Product Narrative: Calmodulin dependent protein kinases (CaM kinases) consist of a
family of Ser/Thr protein kinases including CaMKI, CaMKII and CaMKIV. CaMKs play a
central role in many cellular functions in response to Ca2+ signaling, including synthesis
and secretion of neurotransmitters, axonal transport, long term potentiation etc. CaM
kinase IV is abundantly expressed in the brain and in the thymus and is localized to the
cytoplasm and nucleus.
Product Narrative: Carbonic anhydrase (CA) is an enzyme that assists rapid
interconversion of carbon dioxide and water into carbonic acid, protons, and
bicarbonate ions. It is abundant in all mammalian tissues. Carbonic anhydrases have a
widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux
and it can be used as a histochemical marker of hypoxia.
CaM Kinase Kinase alpha Rabbit Polyclonal
CAS Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10810
0.1ml
Concentrate
Concentrate
C-terminus of human CaM kinase kinase alpha.
E10812
0.5ml
Concentrate
human CAS.
Application: IHC-P
E10814
1.0ml
Concentrate
Application: IHC-P
E10811
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13850
0.1ml
Concentrate
E13852
0.5ml
E13854
1.0ml
Concentrate
E13851
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver Carcinoma
anti-CaM kinase alpha antibody E1385
Human liver carcinoma stained with
anti-CAS antibody E1081
Product Narrative: Ca2+/Calmodulin dependent protein kinases (CaM Kinase I, II and
IV) are considered to play a central role in many cellular functions in response to Ca2+
signaling, including synthesis and secretion of neurotransmitters, axonal transport,
long term potentiation (LTP), receptor function, modification of the cytoskeleton and
regulation of gene expression.
Product Narrative: CAS (Cellular Apoptosis Susceptibility) contains 971 amino acids
with 59% overall sequence homology as compared to yeast chromosome segregation
homolog, CSE1. CAS is highly expressed in testis and fetal liver. CAS expression in
human fibroblasts increases as cells are induced to proliferate and decreases in growth
arrested cells.
Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal
Caspase-1 Rabbit Polyclonal
Clone: SP106
Catalog No.
Size
Format
E3910
0.1ml
Concentrate
Concentrate
human CA-9.
E3912
0.5ml
Concentrate
region of human caspase-1 protein.
Application: IHC-P
E3914
1.0ml
Concentrate
Application: IHC-P
E3911
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4060
0.1ml
Concentrate
M4062
0.5ml
M4064
1.0ml
Concentrate
M4061
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Cellular Localization: Membrane, Nucleus
anti-CA-9 antibody M406
anti-caspase 1 antibody E391
Product Narrative: Carbonic anhydrase (CA) is an enzyme that assists rapid
inter-conversion of carbon dioxide and water into carbonic acid, protons, and
bicarbonate ions. It is abundant in all mammalian tissues. CA-9 is one of the most
inducible genes because of its stability and location within the membrane. Carbonic
anhydrases have a widespread role in regulating pH in normal tissues, by regulating
hydrogen ion (H+) flux. CA-9 is a reliable histochemical marker of hypoxia.
26
Clone: N/A
Product Narrative: Caspase-1/ICE (Interleukin-1 Beta Converting Enzyme) is expressed
as a proenzyme of 45kDa in many tissues and is activated by proteolytic cleavage. Active
caspase-1 is a tetramer of two subunits p10 and p20. Caspase-1 (cystein asparticspecific protease 1) cleaves interleukin beta into its active form which further exerts
its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in
fibroblasts.
Primary Antibodies
Catenin-gamma Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E3680
0.1ml
Concentrate
Concentrate
N-terminus of human caspase-8 protein.
E3682
0.5ml
Concentrate
C-terminus of human catenin-gamma protein.
Application: IHC-P
E3684
1.0ml
Concentrate
Application: IHC-P
E3681
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2280
0.1ml
Concentrate
E2282
0.5ml
E2284
1.0ml
Concentrate
E2281
7.0ml
Ready-to-Use
Species Reactivity*: Human,
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-caspase-8 antibody E228
anti-catenin γ antibody E368
Product Narrative: Caspase-8 binds to the death effector domain (DED) through
an analogous DED domain. Recruitment of caspase-8 to the Fas receptor results
in oligomerization of the caspase-8 protein, which in turn drives its autoactivation
through “self-cleavage.” Activated caspase-8 then activates other downstream caspases
including caspase-9, thereby commiting the cell to undergo apoptosis. This antibody
also detects the processed forms (42/44kDa, 25kDA, and 14kDa) of caspase-8.
Product Narrative: The catenins (α, β and γ) are ubiquitously expressed, cytoplasmic
proteins that associate with E-cadherin. α-catenin can also bind P-cadherin and
N-cadherin. γ-catenin, also known as plakoglobin, is an 82kDa protein that binds with
α-catenin and N-cadherin.
Cathepsin D Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E2820
0.1ml
Concentrate
Immunogen: Recombinant human cathepsin D protein.
Concentrate
human caspase-10.
E2822
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E2824
1.0ml
Concentrate
7.0ml
Ready-to-Use
E2821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10850
0.1ml
Concentrate
E10852
0.5ml
E10854
E10851
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-cathepsin D antibody E282
anti-caspase-10 antibody E1085
Product Narrative: Caspase-10 is a member of the Ced-3 cystein protease family and it
has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
Caspase-1 to-10 function as key components of the apoptotic machinery and act to
destroy specific target proteins which are critical to cellular longevity.
Product Narrative: Cathepsin D is synthesized as a 54kDa precursor and is proteolytically
processed to an intermediate 48kDa single chain. The 48KDa form is further processed
into the more stable 34kDa and 14kDa mature forms. Cathepsin D is an estrogenregulated lysosomal protease that facilitates cancer cell migration and invasion by
digesting the basement membrane, extracellular matrix, and connective tissue.
Cathepsin D is expressed in epithelial cells as well as in macrophages.
Catenin-beta Rabbit Polyclonal
Caveolin-1 Rabbit Monoclonal
Clone: SP43t
Clone: N/A
Catalog No.
Size
Format
M3430
0.1ml
Concentrate
Concentrate
of the catenin-beta protein.
M3432
0.5ml
Concentrate
C-terminus of human caveolin-1 protein.
M3434
1.0ml
Concentrate
Application: IHC-P
M3431
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2260
0.1ml
Concentrate
E2262
0.5ml
E2264
1.0ml
Concentrate
E2261
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Lung Carcinoma
Membrane
Control Lysate: A431
Human lung adenocarcinoma stained with
anti-caveolin-1 antibody M343
anti-catenin-β antibody E226
Product Narrative: The catenins (α, β and γ) are ubiquitously expressed, cytoplasmic
proteins associated with E-cadherin at cellular junctions. β-catenin also binds to
N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are
linked to the cytoskeleton via a direct association between α-actin and α-catenin.
Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing
cellular adhesion.
Product Narrative: Caveolae are 50-100 nm flask-shaped subcompartment of
the plasma membrane. On the basis of morphological studies, caveolae have
been implicated to function in the transcytosis of various macromolecules across
capillary endothelial cells, uptake of small molecules via potocytosis and the
compartmentalization of certain signaling molecules or receptors. Three proteins,
caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components
of caveolae.
27
Caveolin-1 Rabbit Polyclonal
CCR8 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10790
0.1ml
Concentrate
Concentrate
human caveolin-1.
E10792
0.5ml
Concentrate
Immunogen: Synthetic peptide from aa 183-193 of
human CCR8.
Application: IHC-P
E10794
1.0ml
Concentrate
Application: IHC-P
E10791
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10780
0.1ml
Concentrate
E10782
0.5ml
E10784
1.0ml
Concentrate
E10781
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Thymus
anti-caveolin-1 antibody E1078
Human thymus stained with
anti-CCR8 antibody E1079
caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of
caveolae.
Product Narrative: C-C chemokine receptor type 8 (CCR8) encodes a member of
the beta chemokine receptor family. This receptor protein preferentially expresses
in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage
inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this
receptor. CCR8 expression has been reported in spleen and thymus, natural-killer cells,
monocytes, and T cells, and at lower levels in peripheral blood leukocytes.
Caveolin-1 Rabbit Polyclonal
CD1a Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4570
0.1ml
Concentrate
Concentrate
C-terminus of human caveolin-1.
M4572
0.5ml
Concentrate
internal region of human CD1a protein.
Application: IHC-P
M4574
1.0ml
Concentrate
Application: IHC-P
M4571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17640
0.1ml
Concentrate
E17642
0.5ml
E17644
1.0ml
Concentrate
E17641
7.0ml
Ready-to-Use
Clone: SP157
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin, Thymus
Human lung stained with
anti-caveolin-1 antibody E1764
anti-CD1a antibody M457
caveolin-1, caveolin-2 and caveolin-3 have been identified as principle components of
caveolae.
Product Narrative: T cell surface glycoprotein CD1a is a member of the CD1 family
of transmembrane glycoproteins and a MHC Class 1 related cell surface glycoprotein
involved in antigen processing and presentation. It forms heterodimers with beta
2-microglobulin. CD1a is expressed by cortical thymocytes, Langerhan’s cells, dendritic
cells, precursor T lymphoblastic lymphoma, and Langerhan’s cell histiocytosis.
CCR7 Rabbit Polyclonal
CD1a Rabbit Polyclonal
Catalog No.
Size
Format
E19270
0.1ml
Concentrate
Concentrate
human CCR7.
E19272
0.5ml
Concentrate
internal region of human CD1a protein.
Application: IHC-P
E19274
1.0ml
Concentrate
Application: IHC-P
E19271
7.0ml
Ready-to-Use
Size
Format
E18460
0.1ml
Concentrate
E18462
0.5ml
E18464
1.0ml
Concentrate
E18461
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Small Intestine
anti-CCR7 antibody E1846
anti-CD1a antibody E1927
Product Narrative: C-C chemokine receptor type 7 (CCR7) is a member of the G protein
coupled receptor family (subfamily: chemokine). This receptor was identified as a gene
induced by the Epstein Barr virus (EBV). It is expressed particularly in lymphoid tissues
and in activated B and T lymphocytes and has been shown to control the migration of
memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation.
28
Clone: N/A
Clone: N/A
Catalog No.
Product Narrative: T cell surface glycoprotein CD1a is a member of the CD1 family
of transmembrane glycoproteins and a MHC Class 1 related cell surface glycoprotein
involved in antigen processing and presentation. It forms heterodimers with beta
2-microglobulin. CD1a is expressed by cortical thymocytes, Langerhan’s cells, dendritic
cells, precursor T lymphoblastic lymphoma, and Langerhan’s cell histiocytosis.
Primary Antibodies
CD2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E1250
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa
25-209 of human CD2.
E1252
0.5ml
Concentrate
E1254
1.0ml
Concentrate
Species Reactivity: Human*
E1251
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3040
0.1ml
Concentrate
E3042
0.5ml
E3044
1.0ml
Concentrate
E3041
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Synthetic 13-mer peptide
corresponding to internal region of the
epsilon chain of human CD3 protein.
Isotype: Rabbit IgG
SSpecies Reactivity*: Human
Isotype: Rabbit IgG
Molecular Weight: 45-58 kDa
anti-CD2 antibody E304
Product Narrative: The CD2 antigen (LFA-2) is a monomeric 45 to 58kDa glycoprotein.
It is an accessory molecule important in mediating the adhesion of activated T cells and
thymocytes with antigen-presenting cells and target cells. This antibody reacts with the
majority of T cells in peripheral lymphoid tissue, NK cells, cortical thymocytes and most
malignant cells of T cell origin.
Product Narrative: This antibody reacts with the intracytoplasmic portion of the CD3
antigen expressed by T cells. It stains human T cells in both the cortex and medulla of
the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining
normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
CD3 Rabbit Monoclonal
CD3 zeta Rabbit Polyclonal
Catalog No.
Size
Format
M3070
0.1ml
Concentrate
M3072
0.5ml
Concentrate
M3074
1.0ml
Concentrate
M3071
7.0ml
Ready-to-Use
Clone: SP7
Catalog No.
Size
Format
to internal region of the epsilon chain of human
CD3 protein.
E3050
0.1ml
Concentrate
Clone: N/A
E3052
0.5ml
Concentrate
N-terminus of the zeta chain of human CD3 protein.
E3054
1.0ml
Concentrate
Application: IHC-P
E3051
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-CD3 antibody M307
anti-CD3 zeta antibody E305
Product Narrative: CD3 consists of five invariant polypeptide chains that associate to
form three dimers: a heterodimer of gamma and epsilon chains, a heterodimer of delta
and epsilon chains and a homodimer of two zeta chains or a heterodimer of zeta and eta
chains. The zeta chain contains three consecutive copies of the same motif.
Catalog No.
Size
Format
M4620
0.1ml
Concentrate
M4622
0.5ml
Concentrate
M4624
1.0ml
Concentrate
M4621
7.0ml
Ready-to-Use
Clone: SP162
Catalog No.
Size
Format
Immunogen: Synthetic peptide
corresponding to internal region of the
epsilon chain of human CD3 protein.
M3350
0.1ml
Concentrate
Clone: SP35
M3352
0.5ml
Concentrate
internal region of human CD4.
M3354
1.0ml
Concentrate
Application: IHC-P
M3351
7.0ml
Ready-to-Use
SSpecies Reactivity*: Human
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: T Cell Lymphoma, Tonsil
Product Narrative: CD4 is a membrane marker for T-helper cells representing 45% of
peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower
level on monocytes. It is involved in recognition of antigen presented along with MHC
class II by APCs and is expressed in T cell lymphomas. Non-specific nuclear staining is
sometimes seen in some lymphocytes with this antibody when tissues are not fixed
properly.
29
CD7** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3940
0.1ml
Concentrate
Concentrate
M3942
0.5ml
Concentrate
internal region of human CD7 protein.
Application: IHC-P
M3944
1.0ml
Concentrate
Application: IHC-P
M3941
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17680
0.1ml
Concentrate
E17682
0.5ml
E17684
1.0ml
Concentrate
E17681
7.0ml
Ready-to-Use
Clone: SP94
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD4, a single chain transmembrane glycoprotein, is found on a T
cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is
also present on 80% of thymocytes and at a lower level on monocytes. It is involved in
recognition of antigen presented along with MHC class II by APCs. It serves as receptor
for HIV and is expressed in T-cell lymphomas.
Product Narrative: CD7 (gp40, Leu9) is a member of the immunoglobulin gene
superfamily. This protein is found on thymocytes and mature T cells. It plays an essential
role in T cell interactions and also in T cell/B cell interactions during early lymphoid
development. CD7 is expressed on the majority of immature and mature T-lymphocytes,
and T cell leukemia. It is also found on natural killer cells, a small subpopulation of
normal B cells and on maligant B cells.
Clone: SP19
Catalog No.
Size
Format
E18930
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from the intracellular
region of human CD5.
E18932
0.5ml
Concentrate
region of human CD7 protein.
Application: IHC-P
E18934
1.0ml
Concentrate
Application: IHC-P
E18931
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3190
0.1ml
Concentrate
M3192
0.5ml
M3194
1.0ml
Concentrate
M3191
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD5, a transmembrane protein, is found on 95% of thymocytes and
72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed
in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated
T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell
lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center
cell lymphoma are CD5-.
Product Narrative: CD7 (gp40, Leu9) is a member of the immunoglobulin gene
superfamily. This protein is found on thymocytes and mature T cells. It plays an essential
role in T cell interactions and also in T cell/B cell interactions during early lymphoid
development. CD7 is expressed on the majority of immature and mature T-lymphocytes,
and T cell leukemia. It is also found on natural killer cells, a small subpopulation of
normal B cells and on maligant B cells.
Clone: N/A
Catalog No.
Size
Format
M3160
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from the intracellular
region of CD5.
M3162
0.5ml
Concentrate
C-terminus of alpha chain of the human CD8 molecule.
Application: IHC-P
M3164
1.0ml
Concentrate
Application: IHC-P
M3161
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2470
0.1ml
Concentrate
E2472
0.5ml
E2474
1.0ml
Concentrate
E2471
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD5, a transmembrane protein, is found on 95% of thymocytes and
72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed
in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated
T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell
lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center
cell lymphoma are CD5-.
30
Clone: SP16
Product Narrative: The CD8 molecule consists of two chains, termed α and β chain,
which are expressed as a disulfide-linked α/β heterdimer or as an α/α homodimer on
T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β
heterdimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class
I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).
Primary Antibodies
Catalog No.
Size
Format
E2480
0.1ml
Concentrate
E2482
0.5ml
Concentrate
E2484
1.0ml
Concentrate
E2481
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
C-terminus of the cytoplasmic domain of alpha chain of
the CD8 molecule.
M4790
0.1ml
Concentrate
Clone: SP179
M4792
0.5ml
Concentrate
the N-terminus of human CD10 protein.
M4794
1.0ml
Concentrate
Application: IHC-P
M4791
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Contr ol Lysate: LNCaP Cell Lysate
Human kidney stained with
Product Narrative: The CD8 molecule consists of two chains, termed α and β chain,
which are expressed as a disulfide-linked α/β heterdimer or as an α/α homodimer on
T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β
heterdimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class
I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).
Product Narrative: CD10, also known as the Common Acute Lymphocytic Leukemia
Antigen (CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity.
CD10 is a marker for germinal center B cells and is expressed in some B cell leukemia/
lymphomas such as chronic myelocytic leukemia (CML), lymphoblastic, and Burkitt’s
lymphomas as well as some carcinomas such as hepatocellular carcinoma and
renal cell carcinoma.
Clone: N/A
Catalog No.
Size
Format
E18270
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full-length
CD9 protein.
E18272
0.5ml
Concentrate
Application: IHC-P
E18274
1.0ml
Concentrate
Application: IHC-P
E18271
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11010
0.1ml
Concentrate
E11012
0.5ml
E11014
1.0ml
Concentrate
E11011
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: The CD9 antigen is a glycoprotein expressed on the surface of
developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T
lymphocytes and by neurons and glial cells in the peripheral nervous system. In pre-B
cells and platelets, CD9 antigen regulates cell activation aggregation possibly through
an association with the integrin CD41/CD61. It also regulates cell motility in a variety of
cell lines.
CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular lymphomas,
immature B cells, chronic myelocytic leukemia, and renal clear cell carcinoma. It is also
present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high
expression on the brush border kidney, and gut epithelial cells.
Clone: SP67
Catalog No.
Size
Format
M4590
0.1ml
Concentrate
Immunogen: Lewis-X purified from U937 cells.
Concentrate
corresponding to human CD10.
M4592
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
M4594
1.0ml
Concentrate
7.0ml
Ready-to-Use
M45901
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3670
0.1ml
Concentrate
M3672
0.5ml
M3674
M3671
Clone: SP159
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodkin’s Lymphoma
Control Tissue: Renal Cell Carcinoma, Tonsil
Membrane
Human RCC stained with
CD10 is expressed on the cells of lymphoblastic, Burkitt’s, and follicular lymphomas,
immature B cells, chronic myelocytic leukemia, and renal clear cell carcinoma. It is also
present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high
expression on the brush border kidney, and gut epithelial cells.
Human Hodgkin’s Lymphoma stained with
Product Narrative: CD15 (3-fucosyl-N-acetyl-lactosamine) is a carbohydrate adhesion
molecule expressed in majority of circulating granulocytes and monocytes, some
epithelial cells, and is absent in normal lymphocyte. It is also expressed on ReedSternberg cells of Hodgkin’s disease, T cell lymphomas including mycosis fungoides,
some leukemia, and some adenocarcinoma.
31
CD16a** Rabbit Monoclonal
Clone: SP175
Catalog No.
Size
Format
E18960
0.1ml
Concentrate
Concentrate
C-terminus of human CD16a protein.
E18962
0.5ml
Concentrate
C-terminus of human CD19 protein.
Application: IHC-P
E18964
1.0ml
Concentrate
Application: IHC-P
E18961
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4750
0.1ml
Concentrate
M4752
0.5ml
M4754
1.0ml
Concentrate
M4751
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Tonsil
Product Narrative: CD16 is a cluster of differentiation found on the surface of natural
killer cells, neutrophils or polymorphonuclear leukocytes (PMN), monocytes and
macrophages. There are two CD16 isoforms, CD16a and CD16b. CD16a is expressed in
monocytes, macrophages and NK cells and CD16b is expressed in neutrophils.
Product Narrative: CD19 is expressed in B lymphocytes and B-cell lymphoma. It
may also be present on some early myeloid progenitors, particularly those of the
monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly
those of monocytic lineage. Leukemia phenotype studies have demonstrated that the
earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T
lymphocytes, plasma cells, and their tumors.
CD16a** Rabbit Monoclonal
Catalog No.
Size
Format
M4890
0.1ml
Concentrate
M4892
0.5ml
Concentrate
M4894
1.0ml
Concentrate
M4891
7.0ml
Ready-to-Use
Clone: SP189
Catalog No.
Size
Format
derived from the C-terminus of
human CD16a protein.
M3320
0.1ml
Concentrate
Clone: SP32
M3322
0.5ml
Concentrate
M3324
1.0ml
Concentrate
M3321
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma, Tonsil
Membrane
Control Lysate: K562 Cell Lysate
Human B cell lymphoma stained with
Product Narrative: CD16 is a cluster of differentiation found on the surface of natural
killer or polymorphonuclear leukocytes (PMN) cells, neutrophils, monocytes and
macrophages. There are two CD16 isoform CD16a and CD16b. CD16a is expressed in
monocytes, macrophages and NK cells and CD16b is expressed in neutrophils.
Product Narrative: CD20 is a leukocyte surface antigen consisting of four
transmembrane regions and cytoplasmic N- and C-termini. CD20 is expressed primarily
on B cells but has also been detected on both normal and neoplastic T cells. Activation
of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loophelix leucine zipper transcription factors.
Clone: SP110
Catalog No.
Size
Format
E2560
0.1ml
Concentrate
Concentrate
C-terminus of human CD19.
E2562
0.5ml
Concentrate
Application: IHC-P
E2564
1.0ml
Concentrate
E2561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4100
0.1ml
Concentrate
M4102
0.5ml
M4104
1.0ml
Concentrate
M4101
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Membrane
Product Narrative: CD19 is expressed in B lymphocytes and B cell lymphoma. It
may also be present on some early myeloid progenitors, particularly those of the
monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly
those of monocytic lineage. Leukemia phenotype studies have demonstrated that the
earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T
lymphocytes, plasma cells, and their tumors.
32
Product Narrative: CD20 is a leukocyte surface antigen consisting of four
transmembrane regions and cytoplasmic N- and C-termini. CD20 is expressed primarily
on B cells but has also been detected on both normal and neoplastic T cells. Activation
of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loophelix leucine zipper transcription factors.
Primary Antibodies
Clone: SP104
Catalog No.
Size
Format
M4630
0.1ml
Concentrate
Concentrate
M4632
0.5ml
Concentrate
Immunogen: Recombinant protein of
human CD23.
Application: IHC-P
M4634
1.0ml
Concentrate
M4631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4040
0.1ml
Concentrate
M4042
0.5ml
M4044
1.0ml
Concentrate
M4041
7.0ml
Ready-to-Use
Clone: SP163
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD22 is a type 1 integral membrane glycoprotein expressed in both
the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B
cell lymphocyte differentiation at approximately the same stage as the CD19 antigen.
CD22 membrane expression is limited to the late differentiation stages. There are two
different isoforms of CD22. It exists as a monomer and heterodimer. CD22 is strongly
expressed in hairy cell leukemia.
Product Narrative: CD23 is a 45kDa glycoprotein, which is present on a subpopulation
of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBVtransformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE
receptor found on B cells. Expression of CD23 has been detected in neoplastic cells
from cases of B cell chronic lymphocyctic leukemia and some cases of centroblastic/
centrocytic lymphoma.
Clone: N/A
Catalog No.
Size
Format
E3020
0.1ml
Concentrate
Concentrate
E3022
0.5ml
Concentrate
Immunogen: Recombinant protein encoding aa 48-248
of human CD23.
Application: IHC-P
E3024
1.0ml
Concentrate
Application: IHC-P
E3021
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19020
0.1ml
Concentrate
E19022
0.5ml
E19024
1.0ml
Concentrate
E19021
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD22 is a type 1 integral membrane glycoprotein expressed in both
the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B
cell lymphocyte differentiation at approximately the same stage as the CD19 antigen.
CD22 membrane expression is limited to the late differentiation stages. There are two
different isoforms of CD22. It exists as a monomer and heterodimer. CD22 is strongly
expressed in hairy cell leukemia.
Clone: SP23
Catalog No.
Size
Format
M4760
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding
aa 48-248 of human CD23.
M4762
0.5ml
Concentrate
the C-terminus of human CD25 protein.
M4764
1.0ml
Concentrate
M4761
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3230
0.1ml
Concentrate
M3232
0.5ml
M3234
1.0ml
Concentrate
M3231
7.0ml
Ready-to-Use
Clone: SP176
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Lysate: MOLT-4 Cell Lysate
Product Narrative: Interleukin-2 receptor subunit alpha, also known as CD25, is a type I
transmembrane protein and the alpha chain of the IL-2 receptor. CD25 and CD122 form
a heterodimer to act as a high-affinity receptor for IL-2. CD25 is expressed on activated
T cells, activated B cells, some thymocytes, myeloid precursors, oligodendrocytes, and
most B cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and
tumor infiltrating lymphocytes.
33
Clone: N/A
Catalog No.
Size
Format
E11110
0.1ml
Concentrate
Concentrate
E11112
0.5ml
Concentrate
C-terminus of mouse CD31 protein.
Application: IHC-P
E11114
1.0ml
Concentrate
Application: IHC-P
E11111
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17410
0.1ml
Concentrate
E17412
0.5ml
E17414
1.0ml
Concentrate
E17411
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Hodgkin’s Lymphoma, Tonsil
Product Narrative: CD30, a single chain glycoprotein, is synthesized as a 90kDa
precursor which is processed in the Golgi complex into a membrane-bound
phosphorylated mature 105/120kDa glycoprotein. The CD30/Ki-1 antigen is expressed
by mononuclear Hodgkin and multinucleated Reed-Sternberg cells in Hodgkin’s disease,
by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying
proportion of activated T and B cells.
Product Narrative: CD31 is a glycoprotein expressed on endothelial cells and in
platelets. It is known to be involved in cell signaling and cell adhesion.
CD34 (Endothelial Cell Marker) Mouse Monoclonal
Clone: SP38
Catalog No.
Size
Format
E1280
0.1ml
Concentrate
Concentrate
C-terminus of mouse CD31 protein.
E1282
0.5ml
Concentrate
Application: IHC-P
E1284
1.0ml
Concentrate
E1281
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3380
0.1ml
Concentrate
M3382
0.5ml
M3384
1.0ml
Concentrate
M3381
7.0ml
Ready-to-Use
Clone: QBEnd/10
Immunogen: Detergent solubilized vesicular
suspension prepared from a perfusate of
human term placenta.
Application: IHC-P
Isotype: Rabbit IgG
Product Narrative: CD31 is a glycoprotein expressed on endothelial cells and in
platelets. It is known to be involved in cell signaling and cell adhesion.
Product Narrative: CD34, a single chain transmembrane glycoprotein, is selectively
expressed on human lymphoid and myeloid hematopoietic progenitor cells.
CD34 (Endothelial Cell Marker) Rabbit Polyclonal
Clone: SP164
Catalog No.
Size
Format
E17540
0.1ml
Concentrate
Concentrate
C-terminus of mouse CD31.
E17542
0.5ml
Concentrate
human CD34 protein.
Application: IHC-P
E17544
1.0ml
Concentrate
Application: IHC-P
E17541
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4640
0.1ml
Concentrate
M4642
0.5ml
M4644
1.0ml
Concentrate
M4641
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma, Lung, Tonsil
Human angiosarcoma stained with
Product Narrative: Platelet endothelial cell adhesion molecule (PECAM-1) also known
as cluster of differentiation 31 (CD31) is a glycoprotein mainly expressed by endothelial
cells and platelets. It can be also expressed by some inflammatory cells such as
macrophages, granulocytes, NK cells, lymphocytes, and neutrophils.
34
Clone: N/A
Product Narrative: CD34, a single chain transmembrane glycoprotein, is selectively
expressed on human lymphoid and myeloid hematopoietic progenitor cells.
Primary Antibodies
Clone: SP149
Catalog No.
Size
Format
M3550
0.1ml
Concentrate
Concentrate
M3552
0.5ml
Concentrate
the human CD43.
Application: IHC-P
M3554
1.0ml
Concentrate
M3551
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4490
0.1ml
Concentrate
M4492
0.5ml
M4494
1.0ml
Concentrate
M4491
7.0ml
Ready-to-Use
Clone: SP55
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Molecular Weight: 95/115/135 kDa
Product Narrative: CD38 (cluster of differentiation 38), also known as cyclic ADP ribose
hydrolase, is a transmembrane glycoprotein found on the surface of some immune cells
including plasma cells, activated or immature T and B cells, monocytes, and natural killer
cells. CD38 is expressed at high levels in the plasma cell tumor, prostate cancer, stomach
cancer, and neuroblastoma. CD38 is used as one of the plasma cell markers and its
ligand is CD31 molecules.
Product Narrative: CD43 is one of the major glycoproteins of thymocytes and T
lymphocytes. It plays a role in the physiochemical properties of the T cell surface and
in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended
rodlike structure that could protrude above the glycocalyx of the cell and allow multiple
glycan chains to be accessible for binding. During T cell activation CD43 is actively
removed from the T cell antigen presenting cell contact site.
Clone: N/A
Catalog No.
Size
Format
E17950
0.1ml
Concentrate
Concentrate
E17952
0.5ml
Concentrate
Immunogen: Synthetic peptide from internal region of
human CD43 protein.
E17954
1.0ml
Concentrate
Application: IHC-P
E17951
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19170
0.1ml
Concentrate
E19172
0.5ml
E19174
1.0ml
Concentrate
E19171
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Membranea
Molecular Weight: 46 kDa (predicted)
Product Narrative: CD38 (cluster of differentiation 38), also known as cyclic ADP ribose
hydrolase, is a transmembrane glycoprotein found on the surface of many immune cells
including plasma cells, activated or immature T and B cells, monocytes, and natural killer
cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. CD38
is used as one of the plasma cell markers and its ligand is CD31 molecules.
Product Description: CD43 is one of the major glycoproteins of thymocytes and
T lymphocytes. It plays a role in the physiochemical properties of the T cell surface and
in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended
rod-like structure that could protrude above the glycocalyx of the cell and allow multiple
glycan chains to be accessible for binding. During T cell activation CD43 is actively
removed from the T cell antigen presenting cell contact site.
CD44 Std** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3370
0.1ml
Concentrate
Concentrate
M3372
0.5ml
Concentrate
to human CD44.
Application: IHC-P
M3374
1.0ml
Concentrate
M3371
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3700
0.1ml
Concentrate
E3702
0.5ml
E3704
1.0ml
Concentrate
E3701
7.0ml
Ready-to-Use
Clone: SP37
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Esophageal Carcinoma
Product Narrative: The CD40 antigen is a single chain glycoprotein. It is known to be
a member of the tumor necrosis factor/nerve growth factor superfamily and shows a
significant homology to the Hodgkin’s disease associated antigen, CD30. CD40 is present
on all B cells except plasma cells. It is also found on some epithelial cells, carcinomas and
lymphoid dentritic cells.
Human esophageal carcinoma stained with
Product Narrative: CD44 is a cell surface glycoprotein expressed on lymphocytes,
monocytes, and granulocytes. CD44 is also known as homing cell adhesion molecule
(H-CAM), phagocytic glycoprotein-1 (PgP-1), ECM-III, HUTCH-1, or Hermes-1. CD44 has
been implicated in cell migration, in lymphocyte homing, and in tumor metastasis.
35
CD44 Std Mouse Monoclonal
CD45RA Mouse Monoclonal
Clone: SPM504
Clone: SPM521
Catalog No.
Size
Format
E16480
0.1ml
Concentrate
Immunogen: Stimulated human leucocytes.
Concentrate
corresponding to human CD44.
E16482
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
E16484
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16481
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17360
0.1ml
Concentrate
E17362
0.5ml
E17364
E17361
anti-CD45RA antibody E1648
Product Narrative: CD45 or Leukocyte Common Antigen (LCA/T200) is a membrane
sialoglycoprotein. The differential splicing of the exons generates various isoforms.
CD45RA is a single chain glycoprotein. It is expressed on appoximately 40-50% of
peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines.
T-cells expressing CD45RA are naive T-cells while CD45RO+ cells are memory T-cells.
CD44 Std Rabbit Polyclonal
CD56 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E11100
0.1ml
Concentrate
Concentrate
E11102
0.5ml
Concentrate
Immunogen: Membrane preparation of a small cell lung
carcinoma.
Application: IHC-P
E11104
1.0ml
Concentrate
Application: IHC-P
E11101
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17370
0.1ml
Concentrate
E17372
0.5ml
E17374
1.0ml
Concentrate
E17371
7.0ml
Ready-to-Use
Clone: 123C3
Isotype: Rabbit IgG
Control Tissue: Brain, Neuroblastoma, Pancreas
Product Narrative: Three isoforms of neural cell adhesion molecule (NCAM) are
produced by differential splicing of the RNA transcript from a single gene. NCAM
(CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and
neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma.
It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma
and also on natural killer cells.
CD45/T200/LCA Mouse Monoclonal
Clone: SPM496
Catalog No.
Size
Format
Concentrate
Immunogen: Stimulated human leucocytes.
E17510
0.1ml
Concentrate
Immunogen: Recombinant human CD63 protein.
0.5ml
Concentrate
Application: IHC-P
E17512
0.5ml
Concentrate
Application: IHC-P
E12434
1.0ml
Concentrate
E17514
1.0ml
Concentrate
E12431
7.0ml
Ready-to-Use
E17511
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12430
0.1ml
E12432
Clone: SPM524
Control Tissue: Melanoma
Cellular Loc alization: Cytoplasm
Human melanoma stained with
Product Narrative: CD45 leucocyte common antigen (LCA) belongs to a family of at
least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on
hematopoietic cell lines but absent on non-hematopoietic cell lines and normal and
malignant non-hematopoietic tissues. The intracellular portion of these molecules has
protein phosphatase activity and is involved in regulation of transmembrane signals.
Product Narrative: CD63 is expressed on activated platelets. CD63 is a lysosomal
membrane glycoprotein that is translocated to plasma membrane after platelet
activation. It is also present in monocytes and macrophages and is weakly expressed on
granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which
is ME491 and to the platelet antigen PTLGP40.
36
Primary Antibodies
Clone: N/A
Catalog No.
Size
Format
E17420
0.1ml
Concentrate
Concentrate
aa 155-355 of human CD68.
E17422
0.5ml
Concentrate
Immunogen: Recombinant human CD74
protein.
1.0ml
Concentrate
Application: WB
E17424
1.0ml
Concentrate
N/A
N/A
E17421
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13920
0.1ml
Concentrate
E13922
0.5ml
E13924
N/A
Clone: SPM523
Isotype: Rabbit IgG
Control Tissue: N/A
Cellular Localization: N/A
N/A E1392
Product Narrative: CD68 is an intracellular glycoprotein expressed on macrophages
and monocytes.
Product Narrative: Expression of the invariant chain of the HLA-DR antigen (CD74)
by B-lymphocytes begins in the pre-B stage but lost before the final differentiation to
plasma cells. This antibody is expressed in B-lymphocytes and many B cell lymphomas.
CD79a Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3180
0.1ml
Concentrate
Concentrate
M3182
0.5ml
Concentrate
N-terminus region of human CD79a protein.
M3184
1.0ml
Concentrate
Application: IHC-P
M3181
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19160
0.1ml
Concentrate
E19162
0.5ml
E19164
1.0ml
Concentrate
E19161
7.0ml
Ready-to-Use
Clone: SP18
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Lysate: Raji, SH-SY5Y
Molecular Weight: 37 kDa Protein; 110 kDa
Product Narrative: CD68 is an intracellular glycoprotein mainly expressed on
macrophages and monocytes. It could play a role in phagocytic activities of tissue
macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and
cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in
tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML),
and granulocytic sarcoma.
Product Narrative: A disulphide-linked heterodimer, consisting of CD79a/mb-1 and
CD79b/B29 polypeptides, CD79a is non-covalently associated with membrane-bound
immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears
at pre B cell stage and persists until the plasma cell stage where it is found as an
intracellular component. CD79a is found in the majority of acute leukemias of precursor
B cell type, in B cell lines, B cell lymphomas, and in some myelomas.
CD79a Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2490
0.1ml
Concentrate
Concentrate
human CD68 protein.
E2492
0.5ml
Concentrate
from N-terminus of human CD79a protein.
Application: IHC-P
E2494
1.0ml
Concentrate
E2491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19190
0.1ml
Concentrate
E19192
0.5ml
E19194
1.0ml
Concentrate
E19191
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: CD68 is an intracellular glycoprotein mainly expressed on
macrophages and monocytes. It could play a role in phagocytic activities of tissue
macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and
cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in
tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML),
and granulocytic sarcoma.
anti-CD79a antibody E249
Product Narrative: A disulphide-linked heterodimer, consisting of CD79a/mb-1 and
CD79b/B29 polypeptides, CD79a is non-covalently associated with membrane-bound
immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears
at pre B cell stage and persists until the plasma cell stage where it is found as an
intracellular component. CD79a is found in the majority of acute leukemias of precursor
B cell type, in B cell lines, B cell lymphomas, and in some myelomas.
37
CD105/Endoglin/TGF 1/3 Receptor Rabbit Polyclonal
CD95/FAS Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4230
0.1ml
Concentrate
Concentrate
C-terminus of human FAS protein.
E4232
0.5ml
Concentrate
Immunogen: Recombinant protein encoding 26-176 aa
of human CD105.
Application: IHC-P
E4234
1.0ml
Concentrate
Application: IHC-P
E4231
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2500
0.1ml
Concentrate
E2502
0.5ml
E2504
1.0ml
Concentrate
E2501
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Small Intestine
anti-CD95/Fas antibody E250
Product Narrative: CD95, also known as FAS, is a transmembrane glycoprotein. It is a
member of the nerve growth factor receptor/tumor necrosis factor superfamily. This cell
surface molecule mediates receptor-triggered apoptosis. The FAS antigen is expressed
on the surface of various cell types, including activated T and B lymphocytes and T
lymphoblastoid cell lines.
Product Narrative: CD105 or endoglin or GP160 is a Type I transmembrane protein,
which is highly expressed on human vascular endothelial cells. It exists as an Oand N-glycosylated homodimer. Up-regulation of endoglin expression has been
demonstrated in tumor vasculature and proliferating cells, suggesting that it is a
proliferation-associated endothelial cell marker. CD105 binds to TGF-Beta1 and Beta3
with high affinity but not TGF-Beta2.
CD117/c-kit Rabbit Monoclonal
Clone: SP119
Catalog No.
Size
Format
M3260
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length human
CD99 protein.
M3262
0.5ml
Concentrate
cytoplasmic domain of human CD117 protein.
Application: IHC-P
M3264
1.0ml
Concentrate
Application: IHC-P
M3261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4190
0.1ml
Concentrate
M4192
0.5ml
M4194
1.0ml
Concentrate
M4191
7.0ml
Ready-to-Use
Clone: SP26
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Gastrointestinal Stromal Tumor
Human gastrointestinal stromal tumor stained with
Product Narrative: CD99, or MIC2 gene product, or E2 antigen is expressed on the cell
membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary.
The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis,
and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is
strongly expressed on Ewing’s sarcoma cells and primitive peripheral neuroectodermal
tumors.
CD99/MIC2 Rabbit Polyclonal
Clone: N/A
Product Narrative: CD117, also called KIT or c-kit receptor, is a cytokine receptor on the
surface of hematopoietic stem cells and other cells. CD117 gene encodes the human
homolog of the proto-oncogene c-kit. Mutations in this gene are associated with
gastrointestinal stromal tumors, mast cell disease, and chronic myelogenous leukemia.
CD117/c-kit Rabbit Polyclonal
Catalog No.
Size
Format
E3390
0.1ml
Concentrate
Size
Format
0.5ml
Concentrate
Immunogen: Recombinant full length
human CD99 protein.
Catalog No.
E3392
E1440
0.1ml
Concentrate
E3394
1.0ml
Concentrate
E1442
0.5ml
Concentrate
Immunogen: Synthetic peptide from the cytoplasmic
domain of human CD117/c-kit protein.
E3391
7.0ml
Ready-to-Use
Application: IHC-P
Isotype: Rabbit IgG
Membrane
E1444
1.0ml
Concentrate
E1441
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Molecular Weight: 32/28 kDa
Product Narrative: CD99, or MIC2 gene product, or E2 antigen is expressed on the cell
membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary.
The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis,
and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is
strongly expressed on Ewing’s sarcoma cells and primitive peripheral neuroectodermal
tumors.
38
anti-CD117/c-kit antibody E144
Product Narrative: CD117, also called KIT or c-kit receptor, is a cytokine receptor on the
surface of hematopoietic stem cells and other cells. CD117 gene encodes the human
homolog of the proto-oncogene c-kit. Mutations in this gene are associated with
gastrointestinal stromal tumors, mast cell disease, and chronic myelogenous leukemia.
Primary Antibodies
Catalog No.
Size Format
Clone: SP152
Catalog No.
Size Format
Clone: N/A
M4520
0.1ml
Concentrate
Immunogen: Recombinant human CD138 protein.
E13940
0.1ml
Concentrate
M4522
0.5ml
Concentrate
Application: IHC-P
E13942
0.5ml
Concentrate
encoding aa 1-136 of human CD150.
E13944
1.0ml
Concentrate
Application: WB
N/A
N/A
N/A
M4524
1.0ml
Concentrate
M4521
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Lysate: Human Heart
N/A E1394
Product Narrative: CD138 / Syndecan-1, is a transmembrane, heparin sulphate
proteoglycan which is made up of one core protein and five glycosaminoglycans. CD138
is expected to play a role in cell adhesion, cell proliferation, cell migration and cell-matrix
interactions via its receptor for extracellular matrix proteins. It is expressed on the
surface of pre-B cells and plasma cells but is absent from mature B cells. It is lost from the
apoptotic myeloma cells.
Product Narrative: CD150, designated SLAM (Signaling Lymphocyte Activation
Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved
in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory
T cells, immature thymocytes, and a proportion of B cells, and is rapidly induced on
naive T cells after activation. Activated B cells express the membrane bound form, and
the cytoplasmic isoforms of SLAM.
Catalog No.
Size Format
Clone: N/A
Catalog No.
Size Format
Clone: SP96
E4560
0.1ml
Concentrate
M3960
0.1ml
Concentrate
E4562
0.5ml
Concentrate
human CD138.
M3962
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to near
N-terminus of human CD163 protein.
E4564
1.0ml
Concentrate
Application: IHC-P
M3964
1.0ml
Concentrate
Application: IHC-P
E4561
7.0ml
Ready-to-Use
M3961
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung
Product Narrative: CD138/Syndecan-1 is a transmembrane heparin sulphate
proteoglycan which is made up of one core protein and five glycosaminoglycan. CD138
is expected to play a role in cell adhesion. It is expressed on the surface of pre-B cells and
plasma cells but is absent from mature B cells. It is lost from the apoptotic myeloma cells.
Product Narrative: CD163, a 130kDa membrane glycoprotein, is expressed exclusively
on the cell surface of human monocytes and macrophages that evolve predominantly in
the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most
CD64 positive monocytes, and shows higher expression on CD16 positive monocytes.
CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone.
Catalog No.
Size Format
Clone: N/A
Catalog No.
Size Format
Clone: N/A
E11130
0.1ml
Concentrate
E18680
0.1ml
Concentrate
E11132
0.5ml
Concentrate
Immunogen: Recombinant human CD146 protein
encoding aa 433-647 expressed in E. coli.
E18682
0.5ml
Concentrate
E11134
1.0ml
Concentrate
Application: IHC-P
E18684
1.0ml
Concentrate
Application: IHC-P
E11131
7.0ml
Ready-to-Use
E18681
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma
Product Narrative: CD146, also known as the melanoma cell adhesion molecule
(MCAM), is a 113kDa cell adhesion molecule currently used as a marker for endothelial
cell lineage. CD146 belongs to the immunoglobulin super-gene family with five
immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue
cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+
independent cell adhesion molecule involved in heterophilic cell to cell interactions.
Product Narrative: CD163, a 130kDa membrane glycoprotein, is expressed exclusively
on the cell surface of human monocytes and macrophages that evolve predominantly in
the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most
CD64 positive monocytes, and shows higher expression on CD16 positive monocytes.
CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone.
39
CDC2 p34 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4150
0.1ml
Concentrate
Concentrate
E4152
0.5ml
Concentrate
Application: IHC-P
E4154
1.0ml
Concentrate
E4151
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18740
0.1ml
Concentrate
E18742
0.5ml
E18744
1.0ml
Concentrate
E18741
7.0ml
Ready-to-Use
Clone: N/A
from C-terminus of human CDC2 p34
protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-CDC2 p34 antibody E415
Product Narrative: The CD168 antigen is a non-integral cell surface hyaluronan receptor
and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of
a number of proteins, including the focal adhesion kinase occurs. CD168 activation
regulates various cellular processes including cell migration, proliferation, signaling,
regulation of gene expression, cell differentiation, morphogenesis, and metastasis.
Product Narrative: In vertebrates, multiple cyclins have been identified, including a
total of eight such regulatory proteins in mammals. In contrast to the situation in yeast,
the CDC2 p34 kinase is not the only catalytic subunit identified in vertebrates that can
interact with cyclins. CDC2 p34 is essential for the G2 to M transition in vertebrate cells.
Several additional CDC2 p34-related cyclin dependent kinases have been identified.
CD278/ICOS Rabbit Monoclonal
CDH1 Rabbit Polyclonal
Clone: SP98
Catalog No.
Size
Format
E18830
0.1ml
Concentrate
Concentrate
E18832
0.5ml
Concentrate
N-terminus of human CDH1 protein.
Application: IHC-P
E18834
1.0ml
Concentrate
Application: IHC-P
E18831
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3980
0.1ml
Concentrate
M3982
0.5ml
M3984
1.0ml
Concentrate
M3981
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Reactive Lymph Node, Tonsil
Control Tissue: Rectal Carcinoma
Human reactive lymph node stained with
Human rectal carcinoma stained
with anti-CDH1 antibody E1883
Product Narrative: CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family
and is highly expressed in activated T cells. It is essential both for efficient interaction
between T and B cells and for normal antibody responses to T cell dependent antigens. It
enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of
lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective
help for antibody secretion by B cells.
Product Narrative: CDH1 protein is a limiting, substrate-specific activator of anaphasepromoting complex (APC)-dependent proteolysis and is required for the degradation
of the APC substrates, such as CIB2 and ASE1. CDH1 plays an important role in mitotic
regulation.
CD278/ICOS Rabbit Polyclonal
CDK2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3800
0.1ml
Concentrate
Concentrate
M3802
0.5ml
Concentrate
Application: IHC-P
M3804
1.0ml
Concentrate
M3801
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18650
0.1ml
Concentrate
E18652
0.5ml
E18654
1.0ml
Concentrate
E18651
7.0ml
Ready-to-Use
Clone: SP80
corresponding to C-terminus of human
CDK2 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-CD278/ICOS antibody E1865
Product Narrative: CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family
and is highly expressed in activated T cells. It is essential both for efficient interaction
between T and B cells and for normal antibody responses to T cell dependent antigens. It
enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of
lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective
help for antibody secretion by B cells.
40
anti-Cdk2 antibody M380
Product Narrative: CDK2 is a member of the Ser/Thr protein kinase family. It is highly
similar to the gene products of S. cerevisiae CDC28, and S. pombe CDC2. It is a catalytic
subunit of the cyclin-dependent protein kinase complex, whose activity is restricted
to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein
is regulated by the regulatory subunits of the complex including cyclin A or E, CDK
inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).
Primary Antibodies
CDK2 Rabbit Polyclonal
CEA/CD66e Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E16500
0.1ml
Concentrate
Immunogen: Purified human CEA.
Concentrate
from C-terminus of human CDK2 protein.
E16502
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
E16504
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18540
0.1ml
Concentrate
E18542
0.5ml
E18544
E18541
Clone: SPM506
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm, Luminal Membrane
anti-Cdk2 antibody E1854
Human colon carcinoma stained
with anti-CEA antibody E1650
Product Narrative: CDK2 is a member of the Ser/Thr protein kinase family. It is highly
similar to the gene products of S. cerevisiae CDC28, and S. pombe CDC2. It is a catalytic
subunit of the cyclin-dependent protein kinase complex, whose activity is restricted
to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein
is regulated by the regulatory subunits of the complex including cyclin A or E, CDK
inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).
Product Narrative: Carcinoembryonic antigen (CEA), is synthesized during development
in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and
several other tumors. CEA is expressed in various metastatic adenocarcinomas and in
pulmonary adenocarcinomas.
CDX2 Rabbit Monoclonal
CEA/CD66e Rabbit Polyclonal
Clone: SP54
Catalog No.
Size
Format
E2970
0.1ml
Concentrate
Immunogen: Purified human CEA.
Concentrate
N-terminus of human CDX2.
E2972
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E2974
1.0ml
Concentrate
7.0ml
Ready-to-Use
E2971
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3540
0.1ml
Concentrate
M3542
0.5ml
M3544
M3541
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm, Luminal Membrane
anti-CDX2 antibody M354
anti-CEA antibody E297
Product Narrative: CDX2 encodes an intestine-specific transcription factor that is
expressed early in intestinal development and may be involved in the regulation of
proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei
of epithelial cells throughout the intestine, colorectal carcinomas, intestinal metaplasia
of the stomach, and intestinal-type gastric cancer, while it is not expressed in the normal
gastric mucosa.
Product Narrative: Carcinoembryonic antigen (CEA), is synthesized during development
in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and
several other tumors. CEA is expressed in various metastatic adenocarcinomas and in
pulmonary adenocarcinomas.
CDX2 Rabbit Polyclonal
c-erbB-2 (Paired 1248) Rabbit Polyclonal
Catalog No.
Size
Format
E14180
0.1ml
Concentrate
E14182
0.5ml
Concentrate
E14184
1.0ml
Concentrate
N/A
N/A
N/A
Clone: N/A
Catalog No.
Size
Format
corresponding to N-terminus of
human CDX2.
E18480
0.1ml
Concentrate
E18482
0.5ml
Concentrate
E18484
1.0ml
Concentrate
Application: WB
E18481
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Synthetic peptide derived from the region
of human c-erbB-2 that contains non-phosphorylated
tyrosine 1248.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
Control Lysate: Human Placenta
N/A E1418
Product Narrative: CDX2 encodes an intestine-specific transcription factor that is
expressed early in intestinal development and may be involved in the regulation of
proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei
of epithelial cells throughout the intestine, colorectal carcinomas, intestinal metaplasia
of the stomach, and intestinal-type gastric cancer, while it is not expressed in the normal
gastric mucosa.
anti-c-erbB-2 (paired1248) antibody E1848
Product Narrative: c-erbB-2 is a 185kDa transmembrane tyrosine kinase that belongs
to the epidermal growth factor receptor (EGFR) family. This family comprises four
homologous receptors: ERFR, c-erbB-2, cerbB-3 and c-erbB-4. Activation of c-erbB-2
through autophosphorylation at tyrosine residues, is initiated by either homo- or
heterodimerization and triggers intracellular signaling events. This antibody labels
c-cerbB-2 that is non-phosphorylated at 1248 tyrosine residue.
41
c-erbB-2 (Phospho Y1248) Rabbit Polyclonal
Catalog No.
Size
Format
E18470
0.1ml
Concentrate
E18472
0.5ml
Concentrate
E18474
1.0ml
Concentrate
E18471
7.0ml
Ready-to-Use
c-erbB-2/HER-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
region of human c-erbB-2 that contains phosphorylated
tyrosine 1248.
E2440
0.1ml
Concentrate
Clone: N/A
E2442
0.5ml
Concentrate
human c-erbB-2 protein.
E2444
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E2441
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-c-erbB-2 (phospho Y1248) antibody E1847
anti-c-erbB-2 antibody E244
Product Narrative: c-erbB-2 is a 185kDa transmembrane tyrosine kinase belongs
to the epidermal growth factor receptor (EGFR) family. This family comprises four
homologous receptors: ERFR, c-erbB-2, cerbB-3 and c-erbB-4. Activation of c-erbB-2
through autophosphorylation at tyrosine residues, is initiated by either homo- or
heterodimerization and triggers intracellular signaling events. This antibody labels
c-cerbB-2 that is non-phosphorylated at 1248 tyrosine residue.
Product Narrative: c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely
related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is
detectable in a proportion of breast and other adenocarconomas, as well as transitional
cell carcinomas.
c-erbB-2/HER-2 Rabbit Monoclonal
Clone: SP3
Catalog No.
Size
Format
M3710
0.1ml
Concentrate
Concentrate
extracellular domain of human c-erbB-2.
M3712
0.5ml
Concentrate
internal region of human c-erbB-3.
Application: IHC-P
M3714
1.0ml
Concentrate
Application: IHC-P
M3711
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3030
0.1ml
Concentrate
M3032
0.5ml
M3034
1.0ml
Concentrate
M3031
7.0ml
Ready-to-Use
Clone: SP71
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-c-erbB2 antibody M303
cell carcinomas.
Product Narrtive: The gene for c-erbB-3/HER-3 is located on the long arm of human
chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated
into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well
as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is
overexpressed in a variety of tumors including breast, stomach, pancreas, and colon.
Clone: SP101
Catalog No.
Size
Format
E17930
0.1ml
Concentrate
Concentrate
extracellular domain of human c-erbB-2.
E17932
0.5ml
Concentrate
Immunogen: Synthetic peptide from near N-terminus
of human c-erbB-3 protein.
Application: IHC-P
E17934
1.0ml
Concentrate
Application: IHC-P
E17931
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4010
0.1ml
Concentrate
M4012
0.5ml
M4014
1.0ml
Concentrate
M4011
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon Carcinoma
anti-c-erbB-3 / HER-3 antibody E1793
cell carcinomas.
42
Clone: N/A
Product Narrative: The gene for c-erbB-3/HER-3 is located on the long arm of human
Primary Antibodies
Cholecystokinin (CCK-8) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4510
0.1ml
Concentrate
Concentrate
region of human c-erbB-3 protein.
E4512
0.5ml
Concentrate
Application: IHC-P
E4514
1.0ml
Concentrate
E4511
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18580
0.1ml
Concentrate
E18582
0.5ml
E18584
1.0ml
Concentrate
E18581
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Synthetic peptide sulfated
cholecystokinin (26-33) amide
(sulfated CCK-8).
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon Carcinoma
Isotype: Rabbit IgG
anti-c-erbB-3 / HER-3 antibody E1858
anti-CCK-8 antibody E451
Product Narrative: The gene for c-erbB-3/HER-3 is located on the long arm of human
Product Narrative: Cholecystokinin (CCK) is a neuropeptide hormone and
neurotransmitter widely distributed throughout the gastrointestinal (GI) tract and the
central nervous system (CNS). Antibodies that react specifically with CCK are useful
for the study of the mode of action, differential tissue expression and intracellular and
subcellular localization of CCK in the CNS and periphery as well as in neuroendocrine
cells of the digestive system.
Chromogranin A Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3120
0.1ml
Concentrate
Concentrate
C-terminus of human c-erbB-4 protein.
M3122
0.5ml
Concentrate
Immunogen: Recombinant protein encoding human
chromogranin A.
M3124
1.0ml
Concentrate
Application: IHC-P
M3121
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2760
0.1ml
Concentrate
E2762
0.5ml
E2764
1.0ml
Concentrate
E2761
7.0ml
Ready-to-Use
Clone: SP12
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Membrane
anti-c-erbB-4/HER-4 antibody E276
anti-chromogranin A antibody M312
Product Narrative: c-erbB-4 or HER-4 is the fourth member of the class I receptor kinase
family. HER-4 is expressed in normal skeletal muscle, heart, pituitary, cerebellum, and
breast. It is specifically bound and activated by neuregulins, NRG-2, NRG-3, heparinbinding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors
induces cell differentiation. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and
H3396 are found to have the highest levels of mRNA.
Product Narrative: Chromogranin A (a protein of 439 amino acid which is encoded on
chromosome 14) is present in neuroendocrine cells throughout the body, including the
neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic
islets. It has been identified in carcinoid tumors, phenochromocytomas, paragangliomas,
and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific
enolase (NSE) is common in neuroendocrine neoplasms.
c-Fos Rabbit Polyclonal
Chromogranin A Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E1520
0.1ml
Concentrate
Concentrate
region of human c-Fos oncoprotein.
E1522
0.5ml
Concentrate
chromogranin A.
Application: IHC-P
E1524
1.0ml
Concentrate
Application: IHC-P
E1521
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4460
0.1ml
Concentrate
E4462
0.5ml
E4464
1.0ml
Concentrate
E4461
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin
anti-c-fos antibody E446
anti-chromogranin A antibody E152
Product Narrative: The c-Fos proto-oncogene encodes a nuclear phosphoprotein and is
a regulator of transcription, forming a complex with the c-Jun proto-oncogene product.
Expression of the c-Fos gene is low in most normal adult tissues. However, high levels of
expression have been detected in normal skin.
Product Narrative: Chromogranin A (a protein of 439 amino acid which is encoded on
chromosome 14) is present in neuroendocrine cells throughout the body, including the
neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic
islets. It has been identified in carcinoid tumors, phenochromocytomas, paragangliomas,
and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific
enolase (NSE) is common in neuroendocrine neoplasms.
43
Claudin-1 Rabbit Monoclonal
Claudin-4 Rabbit Polyclonal
Clone: SP128
Catalog No.
Size
Format
E3980
0.1ml
Concentrate
Concentrate
C-terminus of human claudin-1 protein.
E3982
0.5ml
Concentrate
human claudin-4.
Application: IHC-P
E3984
1.0ml
Concentrate
Application: IHC-P
E3981
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4280
0.1ml
Concentrate
M4282
0.5ml
M4284
1.0ml
Concentrate
M4281
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver, Hepatocellular Carcinoma
Control Tissue: Ovarian Carcinoma, Tonsil
anti-claudin-1 antibody M428
Human ovarian carcinoma stained with
anti-claudin 4 antibody E398
Product Narrative: Claudin-1 is a member of the transmembrane protein family
claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into
hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain
epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian
tube, liver, pancreas, prostate, and skin.
Product Narrative: Claudin 1-18 proteins are a family of transmembrane proteins
associated with tight junctions. Tight junctions are specialized regions of cell to cell
contact, made up of a network of strands to act as a molecular gasket for preventing the
leakage of ions and water between cells. They are abundant in luminal epithelial sheets
where they maintain epithelial cell polarity. Different tissues exhibit different claudin
composition.
Clone: N/A
Catalog No.
Size
Format
E3750
0.1ml
Concentrate
Concentrate
C-terminus of human claudin-1 peptide.
E3752
0.5ml
Concentrate
C-terminus of mouse claudin-5.
E3754
1.0ml
Concentrate
Application: IHC-P
E3751
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3410
0.1ml
Concentrate
E3412
0.5ml
E3414
1.0ml
Concentrate
E3411
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Skin
Cellular Localization: Cell Junction,
Cytoplasm, Membrane
anti-claudin-5 antibody E375
composition.
composition.
Clone: N/A
Catalog No.
Size
Format
E10590
0.1ml
Concentrate
Concentrate
C-terminus of mouse claudin-3.
E10592
0.5ml
Concentrate
human claudin-7 protein.
Application: IHC-P
E10594
1.0ml
Concentrate
Application: IHC-P
E10591
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3830
0.1ml
Concentrate
E3832
0.5ml
E3834
1.0ml
Concentrate
E3831
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
composition.
44
Clone: N/A
Product Narrative: The claudin superfamily consists of many structurally related proteins
in humans. These proteins, which include claudin 1 through 18, are important structural
and functional components of tight junctions in paracellular transport. Claudins are
located in both epithelial and endothelial cells in all tight junction-bearing tissues.
Claudins, which consist of four trans-membrane domains and two extracellular loops,
make up tight junction strands.
Primary Antibodies
c-Met Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10610
0.1ml
Concentrate
Concentrate
human claudin-10 protein.
E10612
0.5ml
Concentrate
of human c-Met protein.
Application: IHC-P
E10614
1.0ml
Concentrate
Application: IHC-P
E10611
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10240
0.1ml
Concentrate
E10242
0.5ml
E10244
1.0ml
Concentrate
E10241
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Skeletal Muscle
Control Tissue: Breast Carcinoma, Ovarian Carcinoma
anti-claudin-10 antibody E1024
anti-c-Met antibody E1061
Claudins, which consist of four trans-membrane domains and two extracellular loops,
make up tight junction strands.
Product Narrative: The c-Met oncogene was originally isolated from human osteogenic
sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene
product was identified as a transmembrane receptor-like protein with tyrosine kinase
activity that is expressed in many tissues. The c-Met gene product has been identified
as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein
thought to be a humoral mediator of liver regeneration.
c-Met (Paired 1003) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3590
0.1ml
Concentrate
Concentrate
C-terminus of human claudin-11 protein.
M3592
0.5ml
Concentrate
Application: IHC-P
M3594
1.0ml
Concentrate
Species Reactivity: Human
M3591
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E8770
0.1ml
Concentrate
E8772
0.5ml
E8774
1.0ml
Concentrate
E8771
7.0ml
Ready-to-Use
Clone: SP59
Immunogen: Synthetic peptide corresponding to the
region of c-Met that contains non-phosphorylated
tyrosine 1003.
Application: IHC-P
Isotype: Rabbit IgG
Control Tissue: Mouse Brain, Testis
Isotype: Rabbit IgG
anti-c-Met (paired1003) antibody M359
Claudin-11 plays a major role in tight junction-specific obliteration of the intercellular
space.
Product Narrative: The c-Met oncogene was identified as a transmembrane receptorlike protein with tyrosine kinase activity. The c-Met gene product has been identified
as the cell surface receptor for hepatocyte growth factor and is involved in cell
proliferation, scattering, morphogenesis, and survival. This antibody labels c-Met that is
non-phosphorylated at 1003 tyrosine residue.
c-Met** Rabbit Monoclonal
c-Met (Paired 1003) Rabbit Polyclonal
Clone: SP44
Catalog No.
Size
Format
E18110
0.1ml
Concentrate
Concentrate
C-terminus of human c-Met protein.
E18112
0.5ml
Concentrate
Application: IHC-P
E18114
1.0ml
Concentrate
E18111
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3440
0.1ml
Concentrate
M3442
0.5ml
M3444
1.0ml
Concentrate
M3441
7.0ml
Ready-to-Use
Clone: N/A
tyrosine 1003.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-c-Met antibody M344
sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene
product was identified as a transmembrane receptor-like protein with tyrosine kinase
activity that is expressed in many tissues. The c-Met gene product has been identified
as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein
thought to be a humoral mediator of liver regeneration.
anti-c-Met (paired 1003) antibody E1811
45
c-Met (Paired 1349) Rabbit Polyclonal
Catalog No.
Size
Format
E18130
0.1ml
Concentrate
E18132
0.5ml
Concentrate
E18134
1.0ml
Concentrate
E18131
7.0ml
Ready-to-Use
c-Met (Phospho Y1234/1235) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
tyrosine 1349.
E18140
0.1ml
Concentrate
E18142
0.5ml
Concentrate
E18144
1.0ml
Concentrate
Application: IHC-P
E18141
7.0ml
Ready-to-Use
Clone: N/A
region of c-Met that contains phosphorylated tyrosine
1234/1235.
Application: IHC-P
Species Reactivity* Human
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-c-Met (paired 1349) antibody E1813
anti-c-Met (phospho Y1234/1235) antibody E1814
sarcoma cell line by transfection analysis in NIH/3T3 cells. The c-Met protein was
identified as a transmembrane receptor-like protein with tyrosine kinase activity. It is
a cell surface receptor for hepatocyte growth factor and involves in cell proliferation,
scattering, morphogenesis, and survival. This antibody is specific for Met (c-Met), only
when phosphorylated at tyrosine 1234 and 1235.
c-Met (Phospho Y1003) Rabbit Monoclonal
Connexin-43 Rabbit Polyclonal
Catalog No.
Size
Format
M3580
0.1ml
Concentrate
M3582
0.5ml
Concentrate
M3584
1.0ml
Concentrate
M3581
7.0ml
Ready-to-Use
Clone: SP58
Catalog No.
Size
Format
the region of c-Met that contains phosphorylated
tyrosine 1003.
E2740
0.1ml
Concentrate
E2742
0.5ml
Concentrate
E2744
1.0ml
Concentrate
Application: IHC-P
E2741
7.0ml
Ready-to-Use
Clone: N/A
a segment of the 3rd cytoplasmic domain of
rat connexin-43.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Heart
Control Lysate: MCF-7
anti-c-Met (phospho Y1003) antibody M358
Human heart stained with
anti-connexin 43 antibody E274
Product Narrative: The c-Met oncogene was identified as a transmembrane receptorlike protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte
growth factor and involves in cell proliferation, scattering, morphogenesis, and survival.
This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1003.
Product Narrative: The connexins are a group of gap junction proteins which form a
hexamer to compose a connexon. Clusters of connexins form a gap junction through
which low molecular weight proteins may diffuse from cell to cell. Connexins are also
thought to be essential for the development of labor contractions.
c-Met (Phospho Y1003) Rabbit Polyclonal
Corticotropin Releasing Factor (CRF) Rabbit Polyclonal
Catalog No.
Size
Format
E18100
0.1ml
Concentrate
E18102
0.5ml
Concentrate
E18104
1.0ml
Concentrate
E18101
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
the region of c-Met that contains phosphorylated
tyrosine 1003.
E10250
0.1ml
Concentrate
Clone: N/A
E10252
0.5ml
Concentrate
human CRF protein.
E10254
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E10251
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Placenta
anti-c-Met (phospho Y1003) antibody E1810
Product Narrative: The c-Met oncogene was identified as a transmembrane receptorlike protein with tyrosine kinase activity. It is a cell surface receptor for hepatocyte
growth factor and involves in cell proliferation, scattering, morphogenesis, and survival.
This antibody is specific for Met (c-Met), only when phosphorylated at tyrosine 1003.
46
anti-CRF antibody E1025
Product Narrative: Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide,
belongs to a family of structurally related peptides including urocortin, sauvagine and
urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in
endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in
the brain and peripheral nervous system with the highest levels in the hypothalamic
paraventricular nucleus.
Primary Antibodies
COX-1 Rabbit Polyclonal
CREB-Binding Protein (CBP ) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13840
0.1ml
Concentrate
Concentrate
C-terminus of human COX-1.
E13842
0.5ml
Concentrate
aa 2422-2441 of human CBP.
Application: IHC-P
E13844
1.0ml
Concentrate
Application: IHC-P
E13841
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14310
0.1ml
Concentrate
E14312
0.5ml
E14314
1.0ml
Concentrate
E14311
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-COX-1 antibody E1431
anti-CBP antibody E1384
Product Narrative: Cyclooxygenases 1 and 2 (COX-1, COX-2) are enzymes involved in
the conversion of arichidonate to prostaglandins. COX-1 and COX-2 are very similar in
structure and function, though they vary in expression. COX-1 is normally expressed in
most cell types, whereas COX-2 expression is at low levels unless induced by hormonal
stimuli. In some breast cancer and bladder carcinoma studies, COX-1 was expressed in
the stroma cells adjacent to the tumors but not in tumor cells.
Product Narrative: CBP (CREB-binding protein) is a 265kDa nuclear protein which
probably has many of the properties expected of a CREB co-activator. It shows
substantial sequence homology with p300.
COX-2 Rabbit Monoclonal
Cripto-1 Rabbit Polyclonal
Clone: SP21
Catalog No.
Size
Format
E18430
0.1ml
Concentrate
Concentrate
C-terminus of rat COX-2.
E18432
0.5ml
Concentrate
human cripto-1.
Application: IHC-P
E18434
1.0ml
Concentrate
Application: IHC-P
E18431
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3210
0.1ml
Concentrate
M3212
0.5ml
M3214
1.0ml
Concentrate
M3211
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon, Lung
anti-COX-2 antibody M321
anti-Cripto-1 antibody E1843
Product Narrative: COX2 (Cyclooxygenase-2 COX2) is an inducible enzyme in response
to growth factors, tumor promoters, and cytokines. COX2 is induced by a wide variety of
stimuli and was initially identified as immediate-early growth response gene. In addition,
COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma
whereas COX1 levels remain unchanged.
Product Narrative: The cripto gene is expressed both in embryonic stem cells and
during the early phases of embryo development, while in adults it is reactivated in a
wide range of epithelial cancers. The expression of Cripto-1 may represent a useful
marker to identify cancer stem cells in melanoma, and possibly other aggressive tumors
as well. Caveolin-1 can be down-regulated during the process of Cripto-1 mediated
tumorigenesis in the mammary gland.
COX-2 Rabbit Polyclonal
c-TEN Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3830
0.1ml
Concentrate
Concentrate
C-terminus of rat COX-2.
M3832
0.5ml
Concentrate
C-terminus of human c-TEN protein.
Application: IHC-P
M3834
1.0ml
Concentrate
Application: IHC-P
M3831
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3030
0.1ml
Concentrate
E3032
0.5ml
E3034
1.0ml
Concentrate
E3031
7.0ml
Ready-to-Use
Clone: SP83
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Colon, Lung
anti-COX-2 antibody E303
Human liver hepatocellular carcinoma stained with
anti-CTEN antibody M383
Product Narrative: COX2 (Cyclooxygenase-2 COX2) is an inducible enzyme in response
to growth factors, tumor promoters, and cytokines. COX2 is induced by a wide variety of
stimuli and was initially identified as immediate-early growth response gene. In addition,
COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma
whereas COX1 levels remain unchanged.
Product Narrative: c-TEN/TNS4 links the focal adhesion and cell adhesion signaling to
the actin cytoskeleton. It may be involved in cell survival and migration. The protein may
be involved in cell migration, cartilage development and in linking signal transduction
pathways to the cytoskeleton and promote apoptosis, via its cleavage by caspase-3.
47
c-TEN Rabbit Polyclonal
CXCR4 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18440
0.1ml
Concentrate
Concentrate
C-terminus of human c-TEN protein.
E18442
0.5ml
Concentrate
human CXCR4.
Application: IHC-P
E18444
1.0ml
Concentrate
Application: IHC-P
E18441
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18190
0.1ml
Concentrate
E18192
0.5ml
E18194
1.0ml
Concentrate
E18191
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-c-TEN antibody E1819
anti-CXCR4 antibody E1844
Product Narrative: c-TEN/TNS4 links the focal adhesion and cell adhesion signaling to
the actin cytoskeleton. It may be involved in cell survival and migration. The protein may
be involved in cell migration, cartilage development and in linking signal transduction
pathways to the cytoskeleton and promote apoptosis, via its cleavage by caspase-3.
Product Narrative: CXCR4 is a principal coreceptor for T cell tropic strains of HIV1 fusion
and entry of human white blood cells. CXCR4 is also required for the infection by dualtropic strains of HIV1 and mediates CD4 independent infection by HIV2. The chemokine
SDF1 is the ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 is highly
expressed in brain and heart, and in white blood cells, vascular endothelial cells, and
umbilical cord endothelial cells.
Cullin-1 (CUL-1) Rabbit Polyclonal
Cyclin B1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4100
0.1ml
Concentrate
Concentrate
C-terminus of human cullin-1.
E4102
0.5ml
Concentrate
C-terminus of human cyclin B1 protein.
Application: IHC-P
E4104
1.0ml
Concentrate
Application: IHC-P
E4101
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3790
0.1ml
Concentrate
E3792
0.5ml
E3794
1.0ml
Concentrate
E3791
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma, Tonsil
anti-cullin-1 antibody E379
anti-cyclin B1 antibody E410
Product Narrative: Cullin-1 (CUL-1) is a member of the family of human cullin genes
(cullin-1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc53 gene. Cullin-1 forms a
complex with human p19skp1 and F box protein p45skp2, both of which, together with
cdc53, as three subunits, form an ubiquitin ligase controlling proteolysis of G1 cell cycle
regulatory proteins. The cullin-1/p19skp1/p45skp2 complex is thought to play a role in
the ubiquitination of G1 regulatory proteins.
Product Narrative: Cyclin B1 is a regulatory protein involved in mitosis. Cyclin B1
associates with inactive p34 (cdc2) to facilitate phosphorylation of p34 (cdc2) at aa 14Thr
and 15Tyr. Cyclin B1 is expressed predominantly during G2/M phase of the cell cycle.
The cyclin B1-p34 (cdc2) complex plays a critical role in G2 to M transition. Cyclin B1 also
contributes to the switch-like all or none behavior of the cell in deciding to commit to
mitosis.
Cullin-2 (CUL-2) Rabbit Polyclonal
Cyclin D1 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3040
0.1ml
Concentrate
Concentrate
C-terminus of human cullin-2.
M3042
0.5ml
Concentrate
C-terminus of human cyclin D1.
Application: IHC-P
M3044
1.0ml
Concentrate
M3041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4160
0.1ml
Concentrate
E4162
0.5ml
E4164
1.0ml
Concentrate
E4161
7.0ml
Ready-to-Use
Clone: SP4
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mantle Cell Lymphoma,
Tonsil
anti-cullin-2 antibody E416
Product Narrative: Cullin-2 (CUL-2) is a member of human cullin gene family (CUL-1,
-2, -3, -4a, -4b, and -5). It is the core component of multiple cullin-RING-based ECS
(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. The
ECS ligase complexes mediate the ubiquitination of target proteins such as hypoxiainducible factor (HIF).
48
Human mantle cell lymphoma stained with
anti-cyclin D1 antibody M304
Product Narrative: Cyclin D1 or PRAD-1 or BCL-1 is one of the key cell cycle regulators,
and functions in association with CDK4 and / or CDK6 by phosphorylating the Rb
protein. It is a putative proto-oncogene overexpressed in a wide variety of human
neoplasms including mantle cell lymphomas (MCL).
Primary Antibodies
Cyclin D1 Rabbit Polyclonal
CYR61 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18300
0.1ml
Concentrate
Concentrate
C-terminus of human cyclin D1.
E18302
0.5ml
Concentrate
internal region of human CYR61.
E18304
1.0ml
Concentrate
Application: IHC-P
E18301
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E1540
0.1ml
Concentrate
E1542
0.5ml
E1544
1.0ml
Concentrate
E1541
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mantle Cell Lymphoma,
Tonsil
Control Tissue: Colon, Placenta
Human mantle cell lymphoma stained with
anti-cyclin D1 antibody E154
anti-CYR61 antibody E1830
Product Narrative: Cyclin D1 or PRAD-1 or BCL-1 is one of the key cell cycle regulators,
and functions in association with CDK4 and / or CDK6 by phosphorylating the Rb
protein. It is a putative proto-oncogene overexpressed in a wide variety of human
neoplasms including mantle cell lymphomas (MCL).
Product Narrative: CYR61 is a secreted cysteine-rich heparin binding protein, encoded
by a growth factor inducible immediate-early gene. CYR61 is a member of a distinct
family of angiogenic and vasculogenic regulators designated CCN proteins. As an
angiogenic inducer, CYR61 binds to the cell surface receptor to promotes DNA synthesis
of human vascular endothelial cells. CYR61 is also detected in a wide variety of tumors as
it induces tumor growth.
Cyclin E Rabbit Polyclonal
Cytochrome C Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12410
0.1ml
Concentrate
Concentrate
human cyclin E.
E12412
0.5ml
Concentrate
cytochrome C protein.
Application: IHC-P
E12414
1.0ml
Concentrate
Application: IHC-P
E12411
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3600
0.1ml
Concentrate
E3602
0.5ml
E3604
1.0ml
Concentrate
E3601
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Placenta
anti-cyclin E antibody E360
anti-cytochrome c antibody E1241
Product Narrative: Cyclin E is a regulatory subunit of CDK-2 and controls G1/S transition
during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in
tumors but not in the normal tissues, suggesting a post-transcriptional regulation of
Cyclin E. In vitro analysis indicated that these truncated variant isoforms of Cyclin E are
able to phosphorylate histone H1.
Product Narrative: Cytochrome C is an electron transporting protein that resides within
the inter-membrane space of the mitochondria, where it plays a critical role in the
process of oxidative phosphorylation and production of cellular ATP. Cytocrome C is upregulated and it is rapidly released from the mitochondria into the cytosol in apoptotic
processes. Cytosolic cytochrome C participates in the activation of apoptotic effectors
such as caspase-3 and ICE family molecule.
Cyclin E1 Rabbit Monoclonal
D4-GDI Rabbit Polyclonal
Clone: SP146
Catalog No.
Size
Format
E2430
0.1ml
Concentrate
Concentrate
Immunogen: Near the C-terminus of the human cyclin
E1 protein.
E2432
0.5ml
Concentrate
Immunogen: Recombinant full-length
human D4-GDI protein.
Application: IHC-P
E2434
1.0ml
Concentrate
E2431
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4460
0.1ml
Concentrate
M4462
0.5ml
M4464
1.0ml
Concentrate
M4461
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Tonsil
anti-cyclin E1 antibody M446
Product Narrative: G1/S-specific cyclin-E1 (Cyclin E) is a regulatory subunit of CDK2
during G1 phase and controls G1/S transition during the mammalian cell cycle. The
Cyclin E/CDK2 complex phosphorylates p27Kip1 and truncated variant isoforms of cyclin
E can phosphorylate histone H1 to initiate DNA synthesis. Multiple isoforms of cyclin E
are identified in tumor tissues.
anti-D4GDI antibody E243
Product Narrative: D4-GDI belongs to the family of Rho-GDIs or GDP-dissociation
inhibitors for the Rho/Rac family of small G proteins; consisting of RhoGDI-1, D4-GDI/
RhoGDI-2 and RhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential
for GTP-loading and activation of GTPase activity. D4- GDI is located in the cytoplasm
and is involved in the regulation of the membrane association and dissociation cycle of
Rho/Rac proteins.
49
D5DR Rabbit Polyclonal
Desmin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2570
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide corresponding to aa
459-477 of human D5DR.
E2572
0.5ml
Concentrate
Immunogen: Synthetic peptide mapping near the
C-terminus of human desmin.
Application: IHC-P
E2574
1.0ml
Concentrate
Application: IHC-P
E2571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12580
0.1ml
Concentrate
E12582
0.5ml
E12584
1.0ml
Concentrate
E12581
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Sarcoma, Skeletal Muscle
anti-D5DR antibody E1258
anti-desmin antibody E257
Product Narrative: The dopamine receptors are divided into two classes, D1 and D2,
which differ in their functional characteristics. D1DR and D5DR compose the D1 class of
dopamine receptors, and D2DR, D3DR and D4DR compose the D2 class. D1 receptors
stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity.
Product Narrative: Desmin is an intermediate filament protein of both smooth and
striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well
as smooth muscle cells. In skeletal and cardiac muscles, the staining is confined to the
Z-bands giving a characteristic striated appearance.
DAPK2 Rabbit Polyclonal
DFF-45 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3900
0.1ml
Concentrate
Concentrate
C-terminus of human DAPK2 protein.
E3902
0.5ml
Concentrate
N-terminus of human DFF-45 protein.
Application: IHC-P
E3904
1.0ml
Concentrate
Application: IHC-P
E3901
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16860
0.1ml
Concentrate
E16862
0.5ml
E16864
1.0ml
Concentrate
E16861
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-DAPK2 antibody E1686
anti-DFF-45 antibody E390
Product Narrative: Death-associated protein kinase 2 (DAPK2) is a protein belonging to
the serine/threonine protein kinase family. It is pro-apoptotic calcium-regulated serine/
threonine kinase containing death domain. Ectopic expression of DAPK induces cell
death and suppresses oncogenic transformation. DAPK mediates IFN gamma induced
apoptosis. The messenger RNA of DAPK2 is expressed in multiple human tissues.
Product Narrative: DFF45 and DFF40 (ICAD and CAD) are two subunits of heterodimeric
caspase activated DNAse. DFF45/ ICAD (Inhibitor of Caspase Activated DNAse) acts as
a chaperon for appropriate folding of DFF40 and it also acts as inhibitor of DFF40. The
activation of caspase 3 cleaves DFF to release DFF40/CAD, which oligomerizes into a
large active complex and eventually causes the degradation of DNA in nuclei. Hence
cleavage of DFF45 is an important step in apoptosis.
Desmin Rabbit Monoclonal
DHFR Rabbit Polyclonal
Catalog No.
Size
Format
M4380
0.1ml
Concentrate
M4382
0.5ml
Concentrate
M4384
1.0ml
Concentrate
M4381
7.0ml
Ready-to-Use
Clone: SP138
Catalog No.
Size
Format
from the C-terminus of human desmin
protein.
E18220
0.1ml
Concentrate
Clone: N/A
E18222
0.5ml
Concentrate
internal region of human DHFR.
E18224
1.0ml
Concentrate
Application: IHC-P
E18221
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Lysate: Human Skeletal Muscle
anti-desmin antibody M438
Product Narrative: Desmin is a type III intermediate filament protein near the Z-line in
sarcomeres of cardiac, smooth, and striated muscles. It is highly expressed in muscle
cells and their derived tumors.
50
anti-DHFR antibody E1822
Product Narrative: Dihydrofolate reductase (DHFR) converts dihydrofolate into
tetrahydrofolate, and is required for the synthesis of purines, thymidylic acid and certain
amino acids. While the functional dihydrofolate reductase gene has been mapped to
chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase
like genes have been identified on separate chromosomes. Dihydrofolate reductase
deficiency has been linked to megaloblastic anemia.
Primary Antibodies
DJ-1 Rabbit Polyclonal
DOK-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E16830
0.1ml
Concentrate
Concentrate
from C-terminus of human DJ-1 protein.
E16832
0.5ml
Concentrate
N-terminus of human DOK-1 protein.
E16834
1.0ml
Concentrate
Application: IHC-P
E16831
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E8760
0.1ml
Concentrate
E8762
0.5ml
E8764
1.0ml
Concentrate
E8761
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast
anti-DJ-1 antibody E876
anti-DOK-1 antibody E1683
Product Narrative: DJ-1 protein has 189 amino acids and was cloned from a HeLa
cell cDNA library as a novel oncogene which weakly transformed NIH3T3 cells. The
expression of DJ-1 is induced by growth signals and is translocated from the cytoplasm
to the nucleus during the S phase, although no nuclear localization signals are present.
It has been suggested that DJ-1 is a mitogen-dependent oncogene product involved in
Ras-related signal transduction pathway.
Product Narrative: DOK-1 (P62dok, Docking protein 1) is believed to be a mainly
cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase
activation, inhibits cell proliferation and transformation, and promotes cell spreading
and cell migration. DOK-1 is a major substrate for many tyrosine kinases including c-kit,
v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK-1 forms a complex
with ras GTPase-activating protein.
DOG-1 Rabbit Monoclonal
DOK-2 Rabbit Polyclonal
Clone: SP31
Catalog No.
Size
Format
E16730
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide of
human DOG-1 protein.
E16732
0.5ml
Concentrate
C-terminus of human DOK-2 protein.
Application: IHC-P
E16734
1.0ml
Concentrate
Application: IHC-P
E16731
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3310
0.1ml
Concentrate
M3312
0.5ml
M3314
1.0ml
Concentrate
M3311
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-DOG-1 antibody M331
anti-DOK-2 antibody E1673
Product Narrative: DOG-1, a novel marker, is expressed ubiquitously in gastrointestinal
stromal tumors (GIST) irrespective of KIT or PDGFR alpha mutation status.
Product Narrative: Docking proteins interact with receptor tyrosine kinases and
mediate particular biological responses using signal transduction. DOK-2 acts as a
multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By
this mechanism it acts to negatively regulate signal transduction and cell proliferation
controlled by cytokines in a feedback loop. DOK-2 is highly expressed in cells and tissues
of hematopoietic origin as well as in lung.
DOG-1 Rabbit Polyclonal
DRAK2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E16750
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide of human
DOG-1 protein.
E16752
0.5ml
Concentrate
C-terminus of human DRAK2 protein.
Application: IHC-P
E16754
1.0ml
Concentrate
Application: IHC-P
E16751
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16710
0.1ml
Concentrate
E16712
0.5ml
E16714
1.0ml
Concentrate
E16711
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-DOG-1 antibody E1671
anti-DRAK2 antibody E1675
Product Narrative: DOG-1, a novel marker, is expressed ubiquitously in gastrointestinal
stromal tumors (GIST) irrespective of KIT or PDGFR alpha mutation status.
Product Narrative: Two novel serine/threonine kinases that induce apoptosis were
recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosisinducing protein kinases). DRAKs contain a N-terminal kinase domain and a C-terminus
regulation domain. Overexpression of DRAK2 induces apoptosis. DRAK2 is located in
nucleus and its mRNA is ubiquitously expressed in human tissue.
51
Dysferlin Rabbit Polyclonal
E2F-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13610
0.1ml
Concentrate
Concentrate
from C-terminus of human dysferlin.
E13612
0.5ml
Concentrate
E13614
1.0ml
Concentrate
N/A
N/A
N/A
Catalog No.
Size
Format
E2670
0.1ml
Concentrate
E2672
0.5ml
E2674
1.0ml
Concentrate
E2671
7.0ml
Ready-to-Use
Clone: N/A
corresponding to N-terminus of
human E2F-2.
Application: WB
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Membrane
Control Tissue: N/A
Molecular Weight: ~231 kDa
anti-dysferlin antibody E267
N/A E1361
Product Narrative: Dysferlin is the protein product of the 2p13 gene that is defective in
patients with Limb-Girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi Myopathy
(MM). Dysferlin is normally localized to the muscle plasma membrane. In patients with
LGMD2B and MM, immunoreactivity to dysferlin is severely reduced or lost, depending
on the type of mutation.
Product Narrative: E2F transcription factors are functionally regulated by binding to Rb
p110, p107, and p130. E2F-2 is regulated by complex formation with Rb p110. E2F family
members bind DNA as heterodimers with members of the DP family of polypeptides.
Dystrophin Mouse Monoclonal
EGFL7 Rabbit Polyclonal
Clone: SPM499
Catalog No.
Size
Format
E19130
0.1ml
Concentrate
Concentrate
C-terminus of human dystrophin.
E19132
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to an
internal region of human EGFL7 protein.
Application: IHC-P
E19134
1.0ml
Concentrate
Application: IHC-P
E19131
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14010
0.1ml
Concentrate
E14012
0.5ml
E14014
1.0ml
Concentrate
E14011
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
anti-dystrophin antibody E1401
anti-EGFL7 antibody E1913
Product Narrative: Dystrophin is a member of the spectrin/alpha-actinin family of actinbinding, triple helix rod-containing proteins. It is absent or greatly reduced in individuals
with the X-linked recessive Duchenne’s muscular dystrophy disorder, as well as in mice
with the mdx (murine muscular dystrophy) mutation. This antibody is highly specific to
dystrophin and shows no cross-reaction with C-protein (an isoform of α-actinin), α-actin,
or human muscle spectrin.
Product Narrative: Epidermal growth factor-like protein 7 (EGFL7), also known as VEstatin, MEGF7, Notch4-like protein or Zneu1, is a 29.6 kDa protein produced and secreted
by endothelium. The protein is also expressed by some normal and malignant tissues.
The main function of EGFL7 is to regulate angiogenesis and vasculogenesis. A high level
of EFGL-7 can be found in tissues with active angiogenesis of a variety of disorders.
Dystrophin Rabbit Polyclonal
EphA2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4690
0.1ml
Concentrate
Concentrate
from C-terminus of human dystrophin.
M4692
0.5ml
Concentrate
internal region of human EphA2 protein.
M4694
1.0ml
Concentrate
Application: IHC-P
M46901
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2660
0.1ml
Concentrate
E2662
0.5ml
E2664
1.0ml
Concentrate
E2661
7.0ml
Ready-to-Use
Clone: SP169
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-dystrophin antibody E266
Product Narrative: Dystrophin is a member of the spectrin/alpha-actinin family of actinbinding, triple helix rod-containing proteins. It is absent or greatly reduced in individuals
with the X-linked recessive Duchenne’s muscular dystrophy disorder, as well as in mice
with the mdx (murine muscular dystrophy) mutation. This antibody is highly specific to
dystrophin and shows no cross-reaction with C-protein (an isoform of α-actinin), α-actin,
or human muscle spectrin.
52
anti-EphA2 antibodyy M469
Product Narrative: Ephrin type-A receptor 2 (EphA2) is a protein-tyrosine kinase
in the ephrin receptor subfamily. EphA2 plays a role for angiogenesis and tumor
neovascularization. High levels of EphA2 protein expression can be detected in some
tumor cells such as breast carcinoma, bladder carcinoma, renal cell carcinoma (RCC), and
non-small cell lung carcinoma (NSCLC). Inhibition of EphA2 kinase activity is considered
for the treatment of various tumors such as RCC and NSCLC.
Primary Antibodies
Ephrin A4 Rabbit Polyclonal
Epidermal Growth Factor Receptor (EGFR) Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E6690
0.1ml
Concentrate
Concentrate
ephrin A4 protein.
E6692
0.5ml
Concentrate
Immunogen: Extracellular domain of human
recombinant EGFR protein.
Application: IHC-P
E6694
1.0ml
Concentrate
Application: IHC-P
E6691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11150
0.1ml
Concentrate
E11152
0.5ml
E11154
1.0ml
Concentrate
E11151
7.0ml
Ready-to-Use
Clone: SPM341
Isotype: Rabbit IgG
Isotype: Mouse IgG1
Control Tissue: Placenta, Skin, Squamous Cell
Carcinoma
anti-ephrin A4 antibody E1115
anti-EGFR antibody E669
Product Narrative: Ephrin-A4, also known as LERK-4 or ELF-4, is a ligand for the
erythropoietin-producing hepatocellular (Eph) receptor family of tyrosine kinases and
it binds EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. Ephrin-A4 interacts
with activated B lymphocytes and dendritic cells and it is expressed in the adult spleen,
lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and
kidney.
Product Narrative: EGFR is a type I receptor tyrosine kinase with sequence homology
to erbB-1, -2, -3, -4 or HER-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF),
Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HB-EGF),
amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of
breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and
endometrium. It is predominantly present in squamous cell carcinomas.
Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal
Epidermal Growth Factor Receptor (EGFR) Rabbit Polyclonal
Clone: SP9
Catalog No.
Size
Format
E18170
0.1ml
Concentrate
Concentrate
human EGFR protein.
E18172
0.5ml
Concentrate
to C-terminus of human EGFR protein.
Application: IHC-P
E18174
1.0ml
Concentrate
E18171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3090
0.1ml
Concentrate
M3092
0.5ml
M3094
1.0ml
Concentrate
M3091
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Placenta
Control Tissue: Esophageal Carcinoma,
Placenta
anti-EGFR antibody M309
Human esophagus carcinoma stained with
anti-EGFR antibody E1817
Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal
ERAB Rabbit Polyclonal
Clone: SP84
Catalog No.
Size
Format
E10320
0.1ml
Concentrate
Concentrate
to C-terminus of human EGFR protein.
E10322
0.5ml
Concentrate
region of human ERAB protein.
E10324
1.0ml
Concentrate
Application: IHC-P
E10321
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3840
0.1ml
Concentrate
M3842
0.5ml
M3844
1.0ml
Concentrate
M3841
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain, Tonsil
anti-EGFR antibody M384
anti-ERAB antibody E1032
Product Narrative: ERAB also known as 3-hydroxyacyl-CoA dehydrogenase type-2
belongs to the short-chain dehydrogenases/reductases (SDR) family. It is one of the
mutated genes associated with early onset Alzheimer’s disease. It is shown to be
expressed at high levels in Alzheimer’s disease-affected brain and may be related to
neuronal dysfunction in Alzheimer’s disease.
53
ERCC1 Rabbit Monoclonal
ERK-1 Rabbit Polyclonal
Clone: SP68
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human ERCC1 protein.
E3560
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3562
0.5ml
Concentrate
C-terminus of human ERK-1 protein.
E3564
1.0ml
Concentrate
Application: IHC-P
E3561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3680
0.1ml
M3682
0.5ml
M3684
1.0ml
Concentrate
M3681
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Control Tissue: Colon, Non-Small Cell Lung Carcinoma
Isotype: Rabbit IgG
anti-ERCC1 antibody M368
anti-ERK-1 antibody E356
Product Narrative: The mammalian ERCC1 (Excision Repair Cross Complementing)
polypeptide is required for nucleotide excision repair (NER) of damaged DNA
and is homologous to S. cerevisiae RAD10, which functions in repair and mitotic
intrachromosomal recombination. The NER mechanism involves dual incisions on both
sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3’ of
the DNA lesion while the ERCC1-XPF complex makes the 5’ incision.
Product Narrative: ERK-1/extracellular signal-regulated kinase 1/p44 MAP kinase/
microtubule-associated protein 2 kinase/myelin basic protein kinase/EGF receptor
T669 kinase is ubiquitously expressed in various tissues and cells. It gets activated by
phosphorylation of neighboring serine and threonine residues by MEK-1 and MEK-2 in
response to diverse stimuli like growth factors and mitogens.
ERCC1 Rabbit Polyclonal
ERK-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3970
0.1ml
Concentrate
Concentrate
region of human ERCC1 protein.
E3972
0.5ml
Concentrate
C-terminus of mouse ERK-2 protein.
Application: IHC-P
E3974
1.0ml
Concentrate
Application: IHC-P
E3971
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18550
0.1ml
Concentrate
E18552
0.5ml
E18554
1.0ml
Concentrate
E18551
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-ERCC1 antibody E1855
anti-ERK-2 antibodyy E397
Product Narrative: Extracellular signal-regulated kinase 2 (ERK-2) is a serine-threonine
kinase phosphorylates microtubule associated protein-2 and myelin basic protein. This
kinase is an important proximal component of the MAP kinase pathway involved in
transmitting the signals from growth factors, neurotransmitters and hormones at the cell
surface to the transcriptional events in the nucleus.
ERCC1 Rabbit Polyclonal
ESA/Ep-CAM Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E11170
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human
ERCC1 protein.
E11172
0.5ml
Concentrate
Immunogen: Recombinant human ESA protein
expressed in E. coli.
E11174
1.0ml
Concentrate
Application: IHC-P
E11171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18890
0.1ml
Concentrate
E18892
0.5ml
E18894
1.0ml
Concentrate
E18891
7.0ml
Ready-to-Use
Clone: SPM491
Isotype: Rabbit IgG
Control Tissue: Lung Carcinoma,
Rectal Carcinoma
anti-ERCC1 antibody E1889
54
anti-ESA antibody E1117
Product Narrative: EGP40 is a 40kDa transmembrane epithelial glycoprotein, also
identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule
(Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast
majority of carcinomas.
Primary Antibodies
Estrogen Receptor (ER) Rabbit Monoclonal
Catalog No.
Size
Format
M3010
0.1ml
Concentrate
M3012
0.5ml
Concentrate
M3014
1.0ml
Concentrate
M3011
7.0ml
Ready-to-Use
EZH2 Rabbit Polyclonal
Clone: SP1
Catalog No.
Size
Format
from C-terminus of human estrogen
receptor alpha.
E19090
0.1ml
Concentrate
Clone: N/A
E19092
0.5ml
Concentrate
region of human EZH2 protein.
E19094
1.0ml
Concentrate
Application: IHC-P
E19091
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-ER antibody M301
anti-EZH2 antibodyE1909
Product Narrative: This antibody recognizes a protein of 67kDa, which is identified as
estrogen receptor (ER). This antibody strongly stains the nucleus of epithelial cells in
breast carcinomas. The ER is an important regulator of growth and differentiation in the
mammary gland.
Product Narrative: KMT6 / Enhancer of zeste homologue 2 (EZH2) is a histone lysine
methyl transferase which is associated with transcriptional repression. EZH2 is
ubiquitously expressed during early embryo genesis, and becomes restricted to the
central and peripheral nervous systems and sites of fetal hematopoiesis during later
development. The expression of EZH2 is highly expressed in follicular T cells and a
variety of tumors including lymphoma, breast and prostate cancer.
Estrogen Receptor (ER) Rabbit Polyclonal
F4/80 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4150
0.1ml
Concentrate
Concentrate
C-terminus of human estrogen receptor.
M4152
0.5ml
Concentrate
N-terminus of mouse F4/80 protein.
Application: IHC-P
M4154
1.0ml
Concentrate
Application: IHC-P
M4151
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E1640
0.1ml
Concentrate
E1642
0.5ml
E1644
1.0ml
Concentrate
E1641
7.0ml
Ready-to-Use
Clone: SP115
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Mouse Liver
anti-ER antibody E164
Mouse liver stained with
anti-F4/80 antibody M415
Product Narrative: This antibody recognizes a protein of 67kDa, which is identified as
estrogen receptor (ER). This antibody strongly stains the nucleus of epithelial cells in
breast carcinomas. The ER is an important regulator of growth and differentiation in the
mammary gland.
Product Narrative: F4/80 is a cell surface glycoprotein and is reported to vary during
macrophage maturation and activation. The F4/80 antigen is expressed on a wide
range of mature tissue macrophages including Kupffer cells, Langerhans, microglia,
macrophages and a subpopulation of dendritic cells. The ligands and biological
functions of the F4/80 antigen have not yet been determined but recent studies suggest
a role for F4/80 in the generation of efferent CD8+ regulatory T cells.
EZH2** Rabbit Monoclonal
F4/80 Rabbit Polyclonal
Catalog No.
Size
Format
M4290
0.1ml
Concentrate
M4292
0.5ml
Concentrate
M4294
1.0ml
Concentrate
M4291
7.0ml
Ready-to-Use
Clone: SP129
Catalog No.
Size
Format
EZH2 protein.
E18970
0.1ml
Concentrate
Clone: N/A
E18972
0.5ml
Concentrate
N-terminus of mouse F4/80 protein.
E18974
1.0ml
Concentrate
Application: IHC-P
E18971
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Tonsil, Prostate Carcinoma
anti-EZH2 antibody M429
Product Narrative: KMT6/Enhancer of zeste homologue 2 (EZH2) is a histone lysine
methyl transferase associated with transcriptional repression. It is a component of the
polycomb repressive complexes PRC2 and PRC3. EZH2 is highly expressed in follicular
T-cells and in a variety of tumors such as lymphoma, breast and prostate.
anti-F4/80 antibody E1897
Product Narrative: F4/80 antigen is a 160kDa cell surface glycoprotein expressed in
mature tissue macrophages such as Kupffer cells, Langerhans, microglia, macrophages
located in the gut lamina propria, peritoneal cavity, lung, thymus, and bone marrow
stroma. F4/80 is also expressed in a subpopulation of dendritic cells but absent from
macrophages located in T cell areas of the spleen and lymph node. Recent studies
suggest a role for F4/80 in the generation of CD8+ regulatory T cells.
55
FAS Ligand Rabbit Polyclonal
FGFR-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10580
0.1ml
Concentrate
Concentrate
N-terminus of human FAS ligand.
E10582
0.5ml
Concentrate
region of human FGFR-1 protein.
Application: IHC-P
E10584
1.0ml
Concentrate
Application: IHC-P
E10581
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2710
0.1ml
Concentrate
E2712
0.5ml
E2714
1.0ml
Concentrate
E2711
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Testis, Tonsil
Control Tissue: Breast Carcinoma, Pituitary
anti-Fas ligand antibody E271
anti-FGFR-1 antibody E1058
Product Narrative: Fas ligand is a cell surface molecule belonging to the tumor
necrosis factor family, binds to its receptor Fas, thus inducing apoptosis. Various
cells express Fas, where Fas ligand is expressed predominantly on activated T cells.
Fas and Fas ligand are involved in the down-regulation of immune reactions as well
as T cell-mediated cytotoxicity.
Product Narrative: Fibroblast growth factors (FGFs) are members of a large family of
structurally related polypeptides that regulates growth and differentiation in most cells.
FGFR-1 is one of the four genes encoding for high affinity cell surface FGF receptors
(FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors. At
the mRNA level, FGFR-1 is highly expressed in developing human tissues such as brain,
vascular basement membrane, and skin.
FAS-Associated Phosphatase (FAP-1) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10570
0.1ml
Concentrate
Concentrate
aa 2290-2491 of human FAP-1.
E10572
0.5ml
Concentrate
Immunogen: Synthetic peptide from aa 362-374 of
human FGFR-2 protein.
Application: IHC-P
E10574
1.0ml
Concentrate
Application: IHC-P
E10571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12360
0.1ml
Concentrate
E12362
0.5ml
E12364
1.0ml
Concentrate
E12361
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Carcinoma, Placenta
Control Tissue: Breast Carcinoma, Liver Carcinoma
anti-Fap-1 antibody E1236
Product Narrative: FAS-associated phosphatase (FAP-1), a novel protein tyrosine
phosphatase, regulates FAS-induced apoptosis and nerve growth factor receptor
(NGFR)-mediated pro-apoptotic signaling. It has been shown to associate with the
fifteen amino acids at the carboxy terminus of FAS. FAP-1 contains three isoforms and a
membrane-binding domain. It is present in most tissues with the exception of the liver
and skeletal muscle, and is most abundant in lung, kidney and fetal brain.
(FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors.
FGFR-2 is highly expressed in developing human tissues such as brain, choroids plexus,
and lung.
FcRH5 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10230
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near the C-terminus of
human FcRH5 protein.
E10232
0.5ml
Concentrate
region of human FGFR-3 protein.
Application: IHC-P
E10234
1.0ml
Concentrate
Application: IHC-P
E10231
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19250
0.1ml
Concentrate
E19252
0.5ml
E19254
1.0ml
Concentrate
E19251
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Breast Carcinoma
anti-FcRH5 antibody E1925
Product Narrative: Fc receptor homologs (FcRH5), also known as IRTA2 proteins, are
transmembrane proteins with sequence homology to classical Fc receptor families.
FcRH5 function as activating or inhibitory receptors on discrete B cell populations and
are involved in B cell development and differentiation in peripheral lymphoid organs.
FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines
with 1q21 abnormalities.
56
Clone: N/A
(FGFRs). FGFRs are members of the tyrosine kinase family of growth factor receptors.
FGFR-3 is widely expressed in many fetal and adult human and animal tissues.
Primary Antibodies
FLI-1 Rabbit Polyclonal
FLT-1/VEGFR1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2800
0.1ml
Concentrate
Concentrate
C-terminus of human FLI-1.
E2802
0.5ml
Concentrate
C-terminus of human FLT-1.
Application: IHC-P
E2804
1.0ml
Concentrate
Application: IHC-P
Species Reactivity* Human
E2801
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4280
0.1ml
Concentrate
E4282
0.5ml
E4284
1.0ml
Concentrate
E4281
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma, Ewing Sarcoma
Control Tissue: Angiosarcoma, Placenta
Human Ewing’s sarcoma stained with
anti-Fli-1 antibody E428
anti-Flt-1 antibody E280
Product Narrative: Fli-1 is a member of the ETS-1gene family which includes ETS-1, ETS2, ERG-1, ERG-2, ELK, E74, FLI-1, PU-1 and PEA-3. Fli-1 is a nuclear protein and its defects
are the cause of Ewing sarcoma (ES), a highly malignant, metastatic, primitive small
round cell tumor of bone and soft tissue in children and adolescents.
Product Narrative: FLT-1/vascular endothelial growth factor receptor 1 (VEGFR1), a cell
membrane receptor kinase, is a high affinity receptor for vascular endothelial growth
factor and is putatively involved in the growth of endothelial cells and angiogenesis. It
contains seven immunoglobulin like sequences in the extracellular domain and exhibits
sequence similarity to FLK-1 and FLT-4.
FLK-1 (mouse) Rabbit Monoclonal
FLT-4/VEGFR3 Rabbit Polyclonal
Clone: SP123
Catalog No.
Size
Format
E3870
0.1ml
Concentrate
Concentrate
mouse FLK-1 protein.
E3872
0.5ml
Concentrate
C-terminus of human FLT-4 protein.
Application: IHC-P
E3874
1.0ml
Concentrate
Application: IHC-P
E3871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4230
0.1ml
Concentrate
M4232
0.5ml
M4234
1.0ml
Concentrate
M4231
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-FLK-1 antibody M423
anti-Flt-4 antibody E387
Product Narrative: FLK-1/KDR/VEGFR2, a cell membrane receptor kinase, is a high
affinity receptor for vascular endothelial growth factor and is putatively involved in the
growth of endothelial cells and angiogenesis. It contains seven immunoglobulin-like
sequences in the extracellular domain and exhibits sequence similarity to FLT-1
and FLT-4.
Product Narrative: Three cell membrane receptor tyrosine kinases, FLT (also designated
VEGF-R1), FLK-1 (also designated VEGF-R2) and FLT-4 (also designated VEGF-R3), are
putatively involved in the growth of endothelial cells as characterized by the presence
of seven immuno-globulin-like sequences in their extracellular domain. On the basis of
structural similarity to FLT and FLK-1, it has been speculated that FLT-4 might represent a
third receptor for either VEGF or a VEGF-related ligand.
FLK-1/KDR/VEGFR-2 Rabbit Polyclonal
Fn14** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4340
0.1ml
Concentrate
Concentrate
C-terminus of human FLK-1.
M4342
0.5ml
Concentrate
C-terminus of human Fn14 protein.
Application: IHC-P
M4344
1.0ml
Concentrate
M4341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3710
0.1ml
Concentrate
E3712
0.5ml
E3714
1.0ml
Concentrate
E3711
7.0ml
Ready-to-Use
Clone: SP134
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Angiosarcoma, Placenta
Control Tissue: Renal Cell Carcinoma,
Kidney
Control Lysate: Calu-3
anti-Flk-1 antibody E371
Product Narrative: FLK-1/KDR/VEGFR2, a cell membrane receptor kinase, is a high
affinity receptor for vascular endothelial growth factor and is putatively involved in the
growth of endothelial cells and angiogenesis. It contains seven immunoglobulin-like
sequences in the extracellular domain and exhibits sequence similarity to FLT-1
and FLT-4.
Human renal cell carcinoma stained with
anti-Fn14 antibody M434
Product Narrative: Fn14/Tweak receptor/CD266/TNFRSF12A, tumor necrosis factor
receptor superfamily member 12A, is the receptor for Tweak, a member of the TNF
family and was first described as a weak inducer of apoptosis in some cell types. It is
thought to promote angiogenesis and the proliferation of endothelial cells as well as
modulating cellular adhesion to matrix proteins.
57
Fn14 Rabbit Polyclonal
FOXO1A Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Internal region of human Fn14.
E17820
0.1ml
Concentrate
Concentrate
Application: IHC-P
E17822
0.5ml
Concentrate
internal region of human FOXO1A.
E17824
1.0ml
Concentrate
Application: IHC-P
E17821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19080
0.1ml
E19082
0.5ml
E19084
1.0ml
Concentrate
E19081
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Control Tissue: Kidney, Placenta
Isotype: Rabbit IgG
anti-Fn14 antibody E1908
anti-FOXO1A antibody E1782
Product Narrative: Fibroblast growth factor-inducible 14 (Fn14) is the receptor for
Tweak, a member of the TNF receptor family. It was first described as a weak inducer of
apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation
of endothelial cells as well as modulating cellular adhesion to matrix proteins. Fn14 is
highly expressed in glioma and some cancer cases of breast, pancreas, and liver.
Product Narrative: FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a member
of a subfamily of the forkhead homeotic gene family of transcription factors. Recent
studies have shown that this protein can act as either a coactivator or a corepressor of
nuclear receptor activity. This action is mediated through the LXXLL motif found in the
C-terminus of the FOXO1A protein. Chromosomal aberrations involving FOXO1A are
associated with rhabdomyosarcoma 2 (RMS2) or alveolar rhabdomyosarcoma.
FOXA1 Rabbit Monoclonal
FOXO3A Rabbit Polyclonal
Clone: SP88
Catalog No.
Size
Format
E17730
0.1ml
Concentrate
Concentrate
C-terminus of human FOXA1 protein.
E17732
0.5ml
Concentrate
N-terminus of human FOXO3A protein.
Application: IHC-P
E17734
1.0ml
Concentrate
Application: IHC-P
E17731
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3880
0.1ml
Concentrate
M3882
0.5ml
M3884
1.0ml
Concentrate
M3881
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate
Cellular Localization: Nucleus in Breast Carcinoma,
Prostate. Cytoplasm in most malignancies.
Human prostate stained with
anti-FOXA1 antibody M388
anti-FOXO3A antibody E1773
Product Narrative: This gene encodes a member of the forkhead class of DNA-binding
proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific
transcripts such as albumin and transthyretin, and they also interact with chromatin.
Similar family members in mice have roles in the regulation of metabolism and in the
differentiation of the pancreas and liver.
Product Narrative: FOXO3A belongs to the forkhead family of transcription factors
which are characterized by a distinct forkhead domain. This gene likely functions as a
trigger for apoptosis through expression of genes necessary for cell death. Translocation
of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
FOXA1 Rabbit Polyclonal
FOXP1** Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4330
0.1ml
Concentrate
Concentrate
C-terminus of human FOXA1 protein.
M4332
0.5ml
Concentrate
Application: IHC-P
EM4334
1.0ml
Concentrate
M4331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18850
0.1ml
Concentrate
E18852
0.5ml
E18854
1.0ml
Concentrate
E18851
7.0ml
Ready-to-Use
Clone: SP133
corresponding to the C-terminus of human
FOXP1 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Molecular Weight: 55-75 kDa (four isoforms)
Human breast ductal cell carcinoma stained with
anti-FOXA1 antibody E1885
Product Narrative: This gene encodes a member of the forkhead class of DNA-binding
proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific
transcripts such as albumin and transthyretin, and they also interact with chromatin.
Similar family members in mice have roles in the regulation of metabolism and in the
differentiation of the pancreas and liver.
58
anti-FoxP1 antibody M433
Product Narrative: Forkhead box protein P1 (FOXP1) is a transcriptional repressor that
plays an important role in the development of the brain and lung in mammals. It is
essential transcriptional regulator of B cell development. PAX5/FOXP1 translocation
t(9;3)(p13;p14.1) is found in acute lymphoblastic leukemia. FOXP1 is positive in subset of
diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphomas.
Primary Antibodies
FOXP1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E16390
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near C-terminus of
human FOXP1.
E16392
0.5ml
Concentrate
C-terminus of human FOXP4 protein.
Application: IHC-P
E16394
1.0ml
Concentrate
Application: IHC-P
E16391
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19060
0.1ml
Concentrate
E19062
0.5ml
E19064
1.0ml
Concentrate
E19061
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-FoxP1 antibody E1906
anti-FOXP-4 antibody E1639
Product Narrative: Forkhead box (FOX) proteins are a group of 43 conserved
transcription factors that are further divided into subgroups. The FOXP subgroup has
four members, FOXP1 to FOXP4, which are widely expressed and contribute some
critical roles in organ development, immune response, and cancer pathogenesis. FOXP1
is a transcriptional repressor that plays an important role in lung, cardiac valve, and B cell
development.
Product Narrative: FOXP4 gene belongs to subfamily P of the forkhead box (FOX)
transcription factor family. Forkhead box transcription factors play important roles in the
regulation of tissue- and cell type-specific gene transcription during both development
and adulthood. Many members of the forkhead box gene family, including members
of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the
development of tumors of the kidney and larynx.
FOXP3 Rabbit Monoclonal
FPGS Rabbit Polyclonal
Clone: SP97
Catalog No.
Size
Format
E18340
0.1ml
Concentrate
Concentrate
E18342
0.5ml
Concentrate
internal region of human FPGS.
Application: IHC-P
E18344
1.0ml
Concentrate
Application: IHC-P
E18341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3970
0.1ml
Concentrate
M3972
0.5ml
M3974
1.0ml
Concentrate
M3971
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Liver Carcinoma
anti-FoxP3 antibody M397
anti-FPGS antibody E1834
Product Narrative: Forkhead box protein P3 (FOXP3) is a member of the forkhead/
winged-helix family of transcriptional regulators. FOXP3 is essential for normal immune
homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25+ and
CD4+ T cells, at low level in CD4+/CD25- cells, and is absent in CD4-/CD8+ T cells. FOXP-3
may be a master regulatory gene and a more specific marker of regulatory T cells than
other T cells.
Product Narrative: Folylpoly-gamma-glutamate synthetase (FPGS) converts folates to
polyglutamate derivatives by catalyzing the addition of several equivalents of glutamic
acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.
FFPGS is widely expressed in human tumors and is tightly linked either to proliferation
or to a lack of differentiation.
FRA-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4210
0.1ml
Concentrate
Concentrate
E4212
0.5ml
Concentrate
N-terminus of human FRA-2 protein.
Application: IHC-P
E4214
1.0ml
Concentrate
Application: IHC-P
E4211
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18490
0.1ml
Concentrate
E18492
0.5ml
E18494
1.0ml
Concentrate
E18491
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-FOXP3 antibody E1849
anti-Fra2 antibody E421
Product Narrative: Forkhead box protein P3 (FOXP3) is a member of the forkhead/
winged-helix family of transcriptional regulators. FOXP3 is essential for normal immune
homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25+ and
CD4+ T cells, at low level in CD4+/CD25- cells, and is absent in CD4-/CD8+ T cells. FOXP-3
may be a master regulatory gene and a more specific marker of regulatory T cells than
other T cells.
Product Narrative: FRA-2 has homologous sequence with c-FOS, FRA-1, and FOS B.
It forms heterodimers with c-Jun that recognize specific DNA sequences, such as the
binding site for transcription factor AP-1.
59
Fragile Histidine Triad (FHIT) Rabbit Polyclonal
GANP Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E14080
0.1ml
Concentrate
Concentrate
FHIT protein.
E14082
0.5ml
Concentrate
of human GANP.
Application: IHC-P
E14084
1.0ml
Concentrate
Application: IHC-P
E14081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3640
0.1ml
Concentrate
E3642
0.5ml
E3644
1.0ml
Concentrate
E3641
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-FHIT antibody E364
anti-GANP antibody E1408
Product Narrative: This antibody reacts with human FHIT (Fragile Histidine Triad).
Alterations and deletions of the FHIT gene are strongly linked to the genesis and
establishment of human tumors of the lung, cervix, breast, colon, stomach, and
pancreas. In normal cells, FHIT may act as a tumor suppressor.
Product Narrative: Germinal center-associated nuclear protein (GANP) is thought
to be involved in the nuclear localization pathway of MCM3 and in regulation of cell
proliferation of antigen-driven B cells in germinal centers. It carries an MCM-binding
domain in the carboxyl-terminal side and it is up-regulated selectively in germinal
centers.
GADD153 Rabbit Polyclonal
Gastrin-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4490
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full length
GADD153 protein.
E4492
0.5ml
Concentrate
N-terminus of gastrin-1.
Application: IHC-P
E4494
1.0ml
Concentrate
Application: IHC-P
E4491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10980
0.1ml
Concentrate
E10982
0.5ml
E10984
1.0ml
Concentrate
E10981
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-GADD153 antibody E1098
anti-gastrin antibody E449
Product Narrative: GADD153 has been described as a growth arrest and DNA damageinducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression
is induced by a variety of cellular stresses. GADD153 functions to block cells in G1 to
S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to
direct GADD153 dimers away from classical C/EBP binding sites.
Product Narrative: Gastrin is a 17 amino acid peptide hormone and neurotransmitter
widely distributed throughout the gastrointestinal (GI) tract and the central nervous
system (CNS). Antibodies that react specifically with gastrin may be used to study the
differential tissue expression and intracellular and subcellular localization of gastrin in
neuroendocrine cells of the gastrointestinal tract, and in the CNS.
Gamma Glutamylcysteine Synthetase (GCS) Rabbit Polyclonal
GDNF Rabbit Polyclonal
Catalog No.
Size
Format
E16740
0.1ml
Concentrate
E16742
0.5ml
Concentrate
E16744
1.0ml
Concentrate
E16741
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
corresponding to internal region of rat
heavy subunit of GCS protein.
E11020
0.1ml
Concentrate
Clone: N/A
E11022
0.5ml
Concentrate
aa 186-205 of human GDNF.
E11024
1.0ml
Concentrate
Application: IHC-P
E11021
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain (Hippocampus)
Control Tissue: Kidney, Testis
anti-GCS antibody E1674
Product Narrative: Gamma Glutamylcysteune Synthetase (GCS) is the first enzyme and
rate limiting step in the glutathione biosynthesis pathway. Glutathione (GSH) plays an
important role in detoxification of oxidants and toxins from the cells. It is composed
of heavy and light subunits. These subunits are coded by different genes which are
controlled by different mechanisms. The heavy subunit carries the catalytic activity and
can be inhibited through feedback mechanism by GSH.
60
anti-GDNF antibody E1102
Product Narrative: Glial cell line-derived neurotrophic factor (GDNF) has been
identified as a potent neurotrophic factor that enhances survival of midbrain
dopaminergic neurons. GDNF promotes the survival and morphological differentiation
of dopaminergic neurons and increases their high-affinity dopamine uptake. It was
suggested that GDNF may have utility in the treatment of Parkinson’s disease, which is
marked by progressive degeneration of midbrain dopaminergic neurons.
Primary Antibodies
GIV Rabbit Monoclonal
Glial Fibrillary Acidic Protein (GFAP) Mouse Monoclonal
Clone: SP173
Catalog No.
Size
Format
E16510
0.1ml
Concentrate
Immunogen: Porcupine spinal cord.
Concentrate
C-terminus of human GIV protein.
E16512
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E16514
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16511
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4730
0.1ml
Concentrate
M4732
0.5ml
M4734
M4731
Clone: SPM507
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: Astrocytoma, Brain
Control Tissue: Colon Adenocarcinoma
anti-GIV antibody M473
Human astrocytoma stained with
anti-GFAP antibody E1651
Product Narrative: Girdin (girders of actin filaments), also known as APE and GIV, is a
widely expressed cytosolic protein and plays a key modulating role for the AKT-mTOR
signaling pathway. Girdin enhances phosphoinositide 3-kinase (PI3K)-dependent
phosphorylation and kinase activity of AKT1/PKB. It is essential for the integrity of the
actin cytoskeleton and for cell migration. Four isoforms of Girdin have been reported.
Product Narrative: Glial Fibrillary Acidic Protein (GFAP) is specific to astrocytes (i.e., glial
cells) and ependymal cells of the central nervous system. The antibody to GFAP is useful
for documenting astrocytic differentiation in tumors outside the CNS.
GIV (pY1765) Rabbit Monoclonal
Glial Fibrillary Acidic Protein (GFAP) Rabbit Polyclonal
Clone: SP158
Catalog No.
Size
Format
E18320
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide containing
phosphotyrosine at 1765 of human GIV protein.
E18322
0.5ml
Concentrate
C-terminus of human GFAP.
Application: IHC-P
E18324
1.0ml
Concentrate
Application: IHC-P
E18321
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4580
0.1ml
Concentrate
M4582
0.5ml
M4584
1.0ml
Concentrate
M4581
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon Adenocarcinoma
Control Tissue: Astrocytoma
anti-GIV (pY1765) antibody M458
anti-GFAP antibody E1832
Product Narrative: Girdin (girders of actin filements), also known as APE and GIV, is a
widely expressed cytosolic protein and plays a key modulating role for the AKT-mTOR
signaling pathway. Girdin is membrane-associated and interacts with phosphoinositides.
Four isoforms of Girdin have been reported. GIV (pY175) is overexpressed in some
human cancers such as colon, breast, and pancreatic carcinoma.
Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal
Glucagon Rabbit Polyclonal
Clone: SP78
Catalog No.
Size
Format
E18180
0.1ml
Concentrate
Concentrate
C-terminus of human GFAP protein.
E18182
0.5ml
Concentrate
internal region of human glucagon.
Application: IHC-P
E18184
1.0ml
Concentrate
Application: IHC-P
E18181
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3780
0.1ml
Concentrate
M3782
0.5ml
M3784
1.0ml
Concentrate
M3781
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Astrocytoma
anti-GFAP antibody M378
anti-glucagon antibody E1818
Product Narrative: Glucagon is a hormone that is secreted by alpha cells in the pancreas.
Glucagon antagonizes insulin by converting glycogen to glucose in the liver and
increasing blood sugar levels. Glucagon-like peptide 1 (GLP1), Glucagon-like peptide
2 (GLP2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase
activating polypeptide) are in the glucagons hormone family.
61
GluR1 Rabbit Polyclonal
GLUT-1 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4680
0.1ml
Concentrate
Concentrate
human GluR1.
M4682
0.5ml
Concentrate
Application: IHC-P
M4684
1.0ml
Concentrate
M4681
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3060
0.1ml
Concentrate
E3062
0.5ml
E3064
1.0ml
Concentrate
E3061
7.0ml
Ready-to-Use
Clone: SP168
derived from the C-terminus of
human GLUT-1 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-GluR1 antibody E306
anti-GLUT-1 antibody M468
Product Narrative: Glutamate receptors constitute the principal excitatory
neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic
receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric
complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated
calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors
and they activate phopholipases or adenylylcyclase once they are activated.
Product Narrative: Glucose transporter 1 (or GLUT-1), also known as solute carrier family
2, is a protein facilitating the transport of glucose across the plasma membranes of
mammalian cells. Several GLUT isoforms have been identified and shown to function in
response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human
tissues including colon, lung, stomach, esophagus, and breast. GLUT-1 is up-regulated in
some human cancers from these organs.
GluR2/3 Rabbit Polyclonal
GLUT-1 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E13810
0.1ml
Concentrate
Concentrate
human GluR2/3.
E13812
0.5ml
Concentrate
C-terminus of human GLUT-1 protein.
Application: IHC-P
E13814
1.0ml
Concentrate
Application: IHC-P
E13811
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3000
0.1ml
Concentrate
E3002
0.5ml
E3004
1.0ml
Concentrate
E3001
7.0ml
Ready-to-Use
Clone: SPM498
Isotype: Rabbit IgG
Isotype: Mouse IgG2a/k
Control Tissue: Cerebellum
Control Tissue: Breast Carcinoma, Esophageal
Carcinoma
Human cerebellum muscle stained with
anti-GluR2/3 antibody E300
anti-GLUT-1 antibody E1381
calcium channels. Metabotropic glutamate receptors are G protein coupled receptors
Product Narrative: Glucose is fundamental to the metabolism of mammalian cells.
Several glucose transporter protein (Glut) isoforms have been identified and shown
to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in
many human tissues including those of the colon, lung, stomach, esophagus, and breast.
GluR6/7 Rabbit Polyclonal
GLUT-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2840
0.1ml
Concentrate
Concentrate
human GluR6/7.
E2842
0.5ml
Concentrate
Application: IHC-P
E2844
1.0ml
Concentrate
Application: IHC-P
E2841
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2930
0.1ml
Concentrate
E2932
0.5ml
E2934
1.0ml
Concentrate
E2931
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Esophageal
Carcinoma
anti-GluR6/7 antibody E293
calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors
62
anti-GLUT-1antibody E284
Several glucose transporter protein (Glut) isoforms have been identified and shown
to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in
many human tissues including those of the colon, lung, stomach, esophagus, and breast.
Primary Antibodies
GLUT-3 Rabbit Polyclonal
Glypican-3 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3860
0.1ml
Concentrate
Concentrate
M3862
0.5ml
Concentrate
C-terminus of human glypican-3 protein.
Application: IHC-P
M3864
1.0ml
Concentrate
M3861
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3270
0.1ml
Concentrate
E3272
0.5ml
E3274
1.0ml
Concentrate
E3271
7.0ml
Ready-to-Use
Clone: SP86
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-GLUT-3 antibody E327
anti-glypican-3 antibody M386
Several glucose transporter protein (GLUT) isoforms have been identified and shown to
function in response to insulin and IGF-1 induced signaling. GLUT-3 is detectable in a few
normal cell type spermatids in testis with active spermatogenesis, placental trophoblast
membranes, and neurons in brain. GLUT-3 staining is also detectable in human cancers
including those of the ovary, lung, and testis.
Product Narrative: Expression alteration of glypican-3 (GPC3) is associated with several
malignancies and has been identified as an overexpressed gene in hepatocellular
carcinoma (HCC). Glypican-3 is a cell surface proteoglycan that bears heparan sulfate
(HS). It may be involved in the suppression/modulation of growth in the predominantly
mesodermal tissues and organs.
Glutamic Acid Decarboxylase 65 (GAD65) Rabbit Polyclonal
Glypican-3 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18870
0.1ml
Concentrate
Concentrate
human GAD65.
E18872
0.5ml
Concentrate
C-terminus of human glypican-3 protein.
Application: IHC-P
E18874
1.0ml
Concentrate
Application: IHC-P
E18871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3310
0.1ml
Concentrate
E3312
0.5ml
E3314
1.0ml
Concentrate
E3311
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-GAD65 antibody E331
anti-glypican-3 antibody E1887
Product Narrative: Glutamate decarboxylase 2 (GAD65) catalyzes the production of
γ-Aminobutyric acid (GABA). Adults express two forms of glutamate decarboxylase
(GAD), GAD65 and GAD67. Both are expressed in most GABA containing neurons. GAD65
appears to be targeted to the membrane and nerve endings; GAD65 is predominantly
expressed in pancreatic beta cells. Autoantibodies to GAD65 are strongly associated with
insulin-dependent diabetes mellitus.
Product Narrative: Expression alteration of glypican-3 (GPC3) is associated with several
malignancies and has been identified as an overexpressed gene in hepatocellular
carcinoma (HCC). Glypican-3 is a cell surface proteoglycan that bears heparan sulfate
(HS). It may be involved in the suppression/modulation of growth in the predominantly
mesodermal tissues and organs.
Glutamic Acid Decarboxylase 67 (GAD67) Rabbit Polyclonal
GNB2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17940
0.1ml
Concentrate
Concentrate
of mouse GAD67 protein.
E17942
0.5ml
Concentrate
of human GNB2 protein.
Application: IHC-P
E17944
1.0ml
Concentrate
Application: IHC-P
E17941
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10260
0.1ml
Concentrate
E10262
0.5ml
E10264
1.0ml
Concentrate
E10261
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Pancreas
anti-GAD67 antibody E1026
anti-GNB-2 antibody E1794
Product Narrative: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion
of L-glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory
neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic
islets. GAD67 is a cytoplasmic protein and is encoded on chromosome 2.
Product Narrative: Guanine nucleotide-binding protein subunit beta-2 (GNB2) is one
of the three subunits (alpha, beta and gamma) for guanine nucleotide binding proteins
(G proteins). G proteins are membrane associated and heterotrimeric proteins. G
proteins and their receptors (GPCRs) form one of the most prevalent signaling systems in
mammalian cells. G protein signaling system regulates sensory perception, cell growth,
and hormonal regulation.
63
GP200 (Renal Cell Carcinoma Marker) Mouse Monoclonal
GRP78 Rabbit Polyclonal
Clone: SPM487
Catalog No.
Size
Format
Concentrate
Immunogen: Recombinant human gp200 protein.
E12570
0.1ml
Concentrate
Concentrate
Application: IHC-P
E12572
0.5ml
Concentrate
N-terminus of human GRP78 protein.
E12574
1.0ml
Concentrate
Application: IHC-P
E12571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11050
0.1ml
E11052
0.5ml
E11054
1.0ml
Concentrate
E11051
7.0ml
Ready-to-Use
Clone: N/A
Control Tissue: Kidney, Renal Cell Carcinoma
Isotype: Rabbit IgG
Human renal cell carcinoma stained with
anti-gp200 antibody E1105
anti-GRP78 antibody E1257
Product Narrative: GP200 is localized along the brush border of renal tubule and
Bowman’s capsule, the luminal surfaces of breast lobules and ducts and the epididymal
tubular epithelium, cytoplasm of parathyroid parenchymal cells and the colloid of
thyroid follicles. GP200 is reportedly expressed by 93% of primary and 84% of metastatic
renal cell carcinomas.
Product Narrative: The HSP70 family is composed of four highly conserved proteins:
HSP70, HSC70, GRP75 and GRP78. GRP78 is localized in the endoplasmic reticulum
where it receives imported secretory proteins and is involved in the folding and
translocation of nascent peptide chains.
Granzyme B Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13860
0.1ml
Concentrate
Concentrate
human granzyme B.
E13862
0.5ml
Concentrate
Application: IHC-P
E13864
1.0ml
Concentrate
E13861
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2580
0.1ml
Concentrate
E2582
0.5ml
E2584
1.0ml
Concentrate
E2581
7.0ml
Ready-to-Use
Clone: N/A
GRP94 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-granzyme B antibody E258
anti-GRP-94 antibody E1386
Product Narrative: Granzyme A and granzyme B are serine proteases that mediate
apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both
granzyme A and granzyme B are synthesized as inactive proenzymes, and are stored
within cytolytic granules and released by effector cells during degradation. This antibody
should be useful for the localization of granzyme B-containing lytic granules and for the
characterization of activated CTLs or NK cells.
Product Narrative: Glucose-regulated protein 94kDa (GRP-94), also known as
endoplasmin, is a member of human heat shock protein (HSP) 90 family. GRP-94 is a
cytosolic protein that participates in signaling pathways with PKC ε to protect cells from
external damage, particularly in heat shock-mediated events. GRP-94 localizes to the ER
and is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in
human endothelial cells in response to hypoxia by HIF-1.
GRSF-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18690
0.1ml
Concentrate
Concentrate
aa 661-679 of human GRP75 protein.
E18692
0.5ml
Concentrate
region of human GRSF-1 protein.
Application: IHC-P
E18694
1.0ml
Concentrate
Application: IHC-P
E18691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12490
0.1ml
Concentrate
E12492
0.5ml
E12494
1.0ml
Concentrate
E12491
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-GRP75 antibody E1249
anti-GRSF-1 antibody E1869
HSP70, HSC70, GRP75 and GRP78. These proteins serve a variety of roles. GRP75
expression is restricted to the mitochondrial matrix and aids in the translocation and
folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP75
and GRP78 are unresponsive to heat stress and are induced by glucose deprivation.
64
Clone: N/A
Product Narrative: G-rich sequence factor 1 (GRSF-1) is a cytoplasmic protein that
binds RNAs containing the G-rich element. GRSF-1 is up-regulated with prostate cancer
progression and down regulated by the differentiating agents phenylacetate and
phenylbutyrate. The function of GRSF-1 is uncharacterized, but potential roles include
mRNA transport, stabilization, and translation. It might be involved in prostate cancer
metastasis.
Primary Antibodies
GSK-3 Rabbit Polyclonal
H. Pylori Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3010
0.1ml
Concentrate
Immunogen: Purified Helicobacter pylori.
Concentrate
human GSK-3.
E3012
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E3014
1.0ml
Concentrate
Species Reactivity: Human
7.0ml
Ready-to-Use
E3011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2910
0.1ml
Concentrate
E2912
0.5ml
E2914
E2911
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: H. Pylori Infected Tissue
Cellular Localization: H. Pyloric
anti-GSK-3 antibody E291
Human H. pylori infected stomach tissue stained with
anti-H pylori antibody E301
Product Narrative: Glycogen Synthase Kinase-3 (GSK-3) differs from most serine/
threonine kinases in that it is active in the absence of the action of signaling pathways.
Two isoforms exist, GSK-3α and GSK-3β. The function of GSK-3 is to phosphorylate
glycogen synthase and thereby inactivate it. Insulin action stimulates the PI 3-kinase
pathway, resulting in Akt activation, which phosphorylates and inactivates GSK-3.
Product Narrative: Helicobacter pylori (H. Pylori) is known to cause peptic ulcers and
chronic gastritis in human. It is associated with duodenal ulcers and may be involved
in development of adenocarcimona and low grade lymphoma of mucosa-associated
lymphoid tissue in the stomach.
Guanylyl Cyclase beta Rabbit Polyclonal
HDAC1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3550
0.1ml
Concentrate
Concentrate
region of human guanylyl cyclase beta 1, soluble.
E3552
0.5ml
Concentrate
C-terminus of human HDAC1 protein.
Application: IHC-P
E3554
1.0ml
Concentrate
Application: IHC-P
E3551
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10270
0.1ml
Concentrate
E10272
0.5ml
E10274
1.0ml
Concentrate
E10271
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-guanylyl cyclase beta antibody E1027
anti-HDAC-1 antibody E355
Product Narrative: Soluble guanylyl cyclase catalyses in a Mg2+ or Mn2+ dependent
manner, the conversion of guanosine-5’-triphosphate (GTP) to cyclic guanosine-3’,5monophosphate (cGMP) and pyrophosphate. This enzyme is a major physiological
receptor for nitric oxide (NO), an important intra- and intercellular membrane-permeant
signaling molecule.
Product Narrative: Mammalian HADC1 (also designated HD1), HDAC2 (also designated
mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional
regulator Rpd3p, have been identified as histone deacetylases. The deacetylation of
histones is associated with transcriptional silencing.
H. Pylori Mouse Monoclonal
HDAC2 Rabbit Polyclonal
Clone: SPM526
Catalog No.
Size
Format
Concentrate
Immunogen: Purified helicobacter pylori.
E10640
0.1ml
Concentrate
Concentrate
Application: IHC-P
E10642
0.5ml
Concentrate
C-terminus of human HDAC2.
E10644
1.0ml
Concentrate
E10641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18380
0.1ml
E18382
0.5ml
E18384
1.0ml
Concentrate
E18381
7.0ml
Ready-to-Use
Clone: N/A
Control Tissue: H. Pylori Infected Tissue
Isotype: Rabbit IgG
Cellular Localization: H. Pyloric
Human H. pylori infected tissue stained with
anti-H. pylori antibody E1838
Product Narrative: Helicobacter pylori (H. Pylori) is known to cause peptic ulcers and
chronic gastritis in human. It is associated with duodenal ulcers and may be involved
in development of adenocarcimona and low grade lymphoma of mucosa-associated
lymphoid tissue in the stomach.
anti-HDAC-2 antibody E1064
Product Narrative: Histone acetylation is a dynamic process whose levels are
determined by the net activities of histone acetyltransferases (HATs) and the competing
enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear
matrix. Six or seven different mammalian HDACs have been described. HDAC1, HDAC2
and several other HDACs are the catalytic subunits of different multiprotein regulatory
complexes.
65
Heat Shock Protein 60 (HSP60) Rabbit Polyclonal
HMGA2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E16330
0.1ml
Concentrate
Concentrate
to aa 31-50 of human HSP60 protein.
E16332
0.5ml
Concentrate
human HMGA2.
E16334
1.0ml
Concentrate
Application: IHC-P
E16331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12450
0.1ml
Concentrate
E12452
0.5ml
E12454
1.0ml
Concentrate
E12451
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-HSP60 antibody E1245
anti-HMGA2 antibody E1633
Product Narrative: A wide variety of environmental and pathophysiological stressful
condition triggers the synthesis of heat shock proteins or stress response proteins.
HSP60 is a potential antigen in a number of autoimmune diseases including human
arthritis.
Product Narrative: HMGA2, previously known as HMGI-C, belongs to the group of high
mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly
and ubiquitously expressed during embryogenesis. Chromosomal rearrangements
of the HMGA2 gene and overexpression are frequently associated with benign and
malignant tumors, respectively. Human and mouse HMGA2 share 95% amino acid
sequence identity.
Heat Shock Protein 70 (HSP70) Rabbit Polyclonal
Human Growth Hormone (HGH) Rabbit Polyclonal
Catalog No.
Size
Format
E12330
0.1ml
Concentrate
E12332
0.5ml
Concentrate
E12334
1.0ml
Concentrate
E12331
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
corresponding to aa 574-591 of human
HSP70 protein.
E17470
0.1ml
Concentrate
Immunogen: Purified human growth hormone.
E17472
0.5ml
Concentrate
Application: IHC-P
E17474
1.0ml
Concentrate
E17471
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Control Tissue: Anterior Pituitary
Isotype: Rabbit IgG
anti-HSP70 antibody E1233
Human anterior pituitary stained with
anti-HGH antibody E1747
HSP70, HSC70, GRP75 and GRP78. These proteins serve a variety of roles: they act
as molecular chaperones facilitating the assembly of multi-protein complexes, they
participate in the translocation of polypeptides across cell membranes and to the
nucleus and they aid in the proper folding of nascent polypeptide chain. HSP70
expression is strongly induced in response to heat stress.
Product Narrative: HGH is produced by the somatotroph cells in the pituitary. HGH acts
through binding to membrane receptors. Ligand binding induces receptor dimerization
and activation of the receptor-associated kinase. This results in phosphorylation of the
kinase itself, of the receptor, and of many cellular proteins including the Stat proteins as
well as adaptors leading to the activation of the Ras/MAP kinase pathway and of the PI-3
kinase pathway.
hENT1** Rabbit Monoclonal
ID2 Rabbit Polyclonal
Clone: SP120
Catalog No.
Size
Format
E16410
0.1ml
Concentrate
Concentrate
C-terminus of human hENT1 protein.
E16412
0.5ml
Concentrate
human ID2 protein.
Application: IHC-P
E16414
1.0ml
Concentrate
Application: IHC-P
E16411
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4200
0.1ml
Concentrate
M4202
0.5ml
M4204
1.0ml
Concentrate
M4201
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas, Tonsil
anti-hENT1 antibody M420
anti-ID2 antibody E1641
Product Narrative: Human equilibrative nucleoside transporter 1 (hENT1) is a member
of the equilibrative nucleoside transporter family. It is a transmembrane glycoprotein
in the plasma and mitochondrial membranes and mediates the cellular uptake of
nucleosides. Nucleoside transporters such as hENT1 are required for nucleotide
synthesis in cells that lack de novo nucleoside synthesis pathways. These transporters
are necessary for the uptake of cytotoxic nucleosides used for chemotherapies.
66
Clone: N/A
Product Narrative: Inhibitor of differentiation 2 (ID2) protein is a transcriptional
modulator. ID2 participates in the differentiation and cell cycle progression in organisms.
It belongs to a protein family characterized by a helix-loop-helix (HLH) region, but
lacking the basic amino acid domain required to bind to DNA. Id2 can disrupt the
antiproliferative effects of retinoblastoma (Rb) family tumor suppressor proteins and
facilitate the progression of the cell cycle.
Primary Antibodies
ID3 Rabbit Polyclonal
Inhibin-alpha Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17390
0.1ml
Concentrate
Concentrate
C-terminus of human ID3 protein.
E17392
0.5ml
Concentrate
from N-terminus of human inhibin-alpha.
Application: IHC-P
E17394
1.0ml
Concentrate
E17391
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14050
0.1ml
Concentrate
E14052
0.5ml
E14054
1.0ml
Concentrate
E14051
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-Id-3 antibody E1405
anti-inhibin alpha antibody E1739
Product Narrative: DNA-binding protein inhibitor ID-3 (ID3) is a basic helix-loop-helix
(bHLH) protein that inhibits muscle-specific gene expression by the binding of E2Acontaining protein complexes to the muscle creatine kinase E-box enhancer. Under
conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing
E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate
myogenic differentiation.
Product Narrative: Inhibin is a dimeric glycoprotein hormone from the TGF-beta family
made up of alpha and beta subunits. It inhibits the production of follicle-stimulating
hormone from the pituitary while activin stimulates the production of FSH. It is
suggested that inhibin may act as a gonadal tumor suppressor.
IKAROS Rabbit Monoclonal
Integrin beta 5 Rabbit Polyclonal
Clone: SP108
Catalog No.
Size
Format
E2860
0.1ml
Concentrate
Concentrate
human IKAROS.
E2862
0.5ml
Concentrate
human integrin beta 5 subunit.
Application: IHC-P
E2864
1.0ml
Concentrate
Application: IHC-P
E2861
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4080
0.1ml
Concentrate
M4082
0.5ml
M4084
1.0ml
Concentrate
M4081
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow, Colon Carcinoma,
Small Intestine
anti-integrin β5 antibody E286
anti-IKAROS antibody M408
Product Narrative: DNA-binding protein IKAROS functions in the specification and the
maturation of the T lymphocyte. It also interacts with a critical control element in the
terminal deoxynucleotidyl transferase promoter as well as with the promoters for other
genes expressed during early stages of B cell and T cell development.
Product Narrative: Integrins are heterodimers composed of noncovalently associated
transmembrane α and β subunits. Most integrin receptors bind ligands that are
components of the extracellular matrix, including fibronectin, collagen and vitronectin.
Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors.
In addition to mediating cell adhesion and cytoskeletal organization, integrins function
as signaling receptors.
IKAROS Rabbit Polyclonal
Involucrin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10630
0.1ml
Concentrate
Concentrate
N-terminus of human IKAROS protein.
E10632
0.5ml
Concentrate
aa 420-578 of human involucrin.
Application: IHC-P
E10634
1.0ml
Concentrate
Application: IHC-P
E10631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19000
0.1ml
Concentrate
E19002
0.5ml
E19004
1.0ml
Concentrate
E19001
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-IKAROS antibody E1900
anti-involucrin antibody E1063
Product Narrative: DNA-binding protein IKAROS functions in the specification and the
maturation of the T lymphocyte. It also interacts with a critical control element in the
terminal deoxynucleotidyl transferase promoter as well as with the promoters for other
genes expressed during early stages of B cell and T cell development.
Product Narrative: Involucrin is a cytoplasmic protein precursor of the epidermal
cornified envelope that becomes cross-linked by transglutaminase during envelope
assembly. Involucrin is expressed in a range of stratified squamous epithelia, including
the cornea which lacks a distinct cornified layer. The protein is a useful marker of
terminal differentiation. It is tightly linked to the onset of differentiation and first
expressed in the immediate suprabasal layers of the epidermis.
67
IPO-38 (Proliferation Marker) Mouse Monoclonal
J-chain Rabbit Monoclonal
Clone: SPM515
Catalog No.
Size
Format
M4050
0.1ml
Concentrate
Concentrate
Immunogen: Spleen cells of a patient with hairy cell
leukemia.
M4052
0.5ml
Concentrate
Immunogen: Synthetic peptide near the internal region
of human J-chain.
Application: IHC-P
M4054
1.0ml
Concentrate
Application: IHC-P
M4051
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16580
0.1ml
Concentrate
E16582
0.5ml
E16584
1.0ml
Concentrate
E16581
7.0ml
Ready-to-Use
Clone: SP105
Isotype: Mouse IgM/k
Isotype: Rabbit IgG
anti-IPO antibody E1658
anti-J-chain antibody M405
Product Narrative: IPO-38 antigen is present in the nuclei of proliferating cells such as
Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias, breast
and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the
cells of non-stimulated lymphocytes and granulocytes.
Product Narrative: J chain is a small glycopeptide and is structurally unrelated to heavy
or light chains, but is synthesized by all plasma cells. J chain is linked to IgA and IgM
by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. B
cells secrete J chain at an early stage of differentiation. J chains are present in a large
proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil
and lymph node.
IRS-1 Rabbit Polyclonal
J-chain Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E19010
0.1ml
Concentrate
Concentrate
aa 1223-1242 of human IRS-1.
E19012
0.5ml
Concentrate
C-terminus of human J-chain protein.
Application: IHC-P
E19014
1.0ml
Concentrate
Application: IHC-P
E19011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12590
0.1ml
Concentrate
E12592
0.5ml
E12594
1.0ml
Concentrate
E12591
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-IRS-1 antibody E1259
anti-J-chain antibody E1901
Product Narrative: The insulin receptor substrate-1 (IRS-1), a 170-185kDa protein major
substrate of the insulin receptor is phosphorylated in response to stimulation of cells by
insulin, insulin-like growth factor (IGF-I) and interleukin 4. IRS-1 is phosphorylated on
serine, threonine and tyrosine residues in a variety of tissues.
Product Narrative: J chain is a small glycopeptide and is structurally unrelated to heavy
or light chains, but is synthesized by all plasma cells. J chain is linked to IgA and IgM
by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. B
cells secrete J chain at an early stage of differentiation. J chains are present in a large
proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil
and lymph node.
JAB1 Rabbit Polyclonal
Jena-Muenchen4 (JM4) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E14000
0.1ml
Concentrate
Concentrate
human JAB1 protein.
E14002
0.5ml
Concentrate
aa 165-178 of human JM4.
Application: IHC-P
E14004
1.0ml
Concentrate
Application: IHC-P
E14001
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10280
0.1ml
Concentrate
E10282
0.5ml
E10284
1.0ml
Concentrate
E10281
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-JAB-1 antibody E1028
anti-JM4 antibody E1400
Product Narrative: Jun activation domain-binding protein-1 (JAB1) also designated
COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also
promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts
with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in
mammalian tissues. It is localized both in the nucleus and the cytoplasm.
68
Clone: N/A
Product Narrative: JM4 is a 19kDa four-transmembrane protein binding to the CCR5
receptor. It plays a role in the regulation of intracellular protein transport. It is expressed
in normal brain, small intestine, lung, spleen, and pancreas and has also been detected
in tumors of breast, colon, lung, and ovary.
Primary Antibodies
Kappa Light Chain** Rabbit Monoclonal
Keratin 5** Rabbit Monoclonal
Clone: SP148
Catalog No.
Size
Format
M4780
0.1ml
Concentrate
Concentrate
Immunogen: Free kappa light chain from
pooled human IgG lambda myeloma sera.
M4782
0.5ml
Concentrate
internal region of human keratin 5 protein
M4784
1.0ml
Concentrate
Application: IHC-P
M4781
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4480
0.1ml
Concentrate
M4482
0.5ml
M4484
1.0ml
Concentrate
M4481
7.0ml
Ready-to-Use
Clone: SP178
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Tonsil
Control Lysate: Human Spleen
anti-kappa light chain antibody M448
anti-keratin 5 antibody M478
Product Narrative: Kappa light chains are polypeptide chains resided in the cell
membrane and cytoplasmic regions of normal B cells and plasma cells. Individual
lymphoid cell only contains a single light chain class. This clonal restriction may be used
to indicate the polyclonal or monoclonal nature of B cell and plasma cell populations.
The ratio of kappa to lambda is about 2:1. The level of kappa can be greatly elevated in
serum of patients with multiple myeloma or other B cell malignancies.
Product Narrative: Keratin-5 (CK5) is a basic (type II) polypeptides expressed by
squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the
prostate. It is expressed in most epithelial mesotheliomas, but not by most pulmonary
adenocarcinomas. CK5 along with CK6 is expressed in almost all squamous cell
carcinomas, half of transitional cell carcinomas, and many undifferentiated large cell
carcinomas.
Kappa Light Chain (B Cell Marker) Mouse Monoclonal
Keratin 5 Rabbit Polyclonal
Clone: SPM508
Catalog No.
Size
Format
Concentrate
Immunogen: B-lymphoma cells.
E13820
0.1ml
Concentrate
Concentrate
E13822
0.5ml
Concentrate
C-terminus of human cytokeratin 5.
E13824
1.0ml
Concentrate
Application: IHC-P
E13821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16520
0.1ml
E16522
0.5ml
E16524
1.0ml
Concentrate
E16521
7.0ml
Ready-to-Use
Isotype: Mouse IgG1
Clone: N/A
Isotype: Rabbit IgG
Control Tissue: Breast, Mesothelioma, Prostate, Skin
anti-kappa light chain antibody E1652
anti-keratin 5 antibody E1382
Product Narrative: Immunoglobulins have similar structures of two identical heavy
chains and two identical light chains. Both the heavy chains and the light chains are
divided into constant and variable regions. The constant regions have the same amino
acid sequences between all the immunoglobulin classes. The variable regions have
approximately 110 amino acids with high sequence variability. Kappa light chain
contains one immunoglobulin like domain.
Product Narrative: Twenty human keratins are divided into acidic and basic subfamilies.
Members of the acidic and basic subfamilies are found together in pairs. The
composition of keratin pairs varies with the epithelial cell type, stage of differentiation,
cellular growth environment, and disease state. Human keratins are useful markers in
cancer research. Cytokeratin 5 is expressed in breast myoepithelia cells, prostate basal
cells, most epithelial and biphasic mesotheliomas..
Keratin 5 Rabbit Monoclonal
Clone: SP27
Catalog No.
Size
Format
M3870
0.1ml
Concentrate
Concentrate
M3872
0.5ml
Concentrate
from C-terminus of human keratin 6 protein.
M3874
1.0ml
Concentrate
M3871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3270
0.1ml
Concentrate
M3272
0.5ml
M3274
1.0ml
Concentrate
M3271
7.0ml
Ready-to-Use
Clone: SP87
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Mesothelioma,
Prostate, Skin
Control Tissue: Prostate, Skin
Human prostate adenocarcinoma stained with
Product Narrative: Twenty human keratins are divided into acidic and basic subfamilies.
Members of the acidic and basic subfamilies are found together in pairs. The
composition of keratin pairs varies with the epithelial cell type, stage of differentiation,
cellular growth environment, and disease state. Human keratins are useful markers in
cancer research. Cytokeratin 5 is expressed in breast myoepithelia cells, prostate basal
cells, most epithelial and biphasic mesotheliomas.
Human prostate cancer stained with
Product Narrative: Cytokeratin 6 (CK6) and 16 (CK16) are expressed in keratinocytes,
which undergo rapid turnover in the suprabasal region. CK6 is found in basal cells of
prostate glands, hair follicles, suprabasal cells of a variety of internal stratified epithelia
and in epidermis. Epidermal injury results in activation of keratinocytes which express
CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell
carcinomas.
69
Clone: N/A
Catalog No.
Size
Format
E18400
0.1ml
Concentrate
Concentrate
C-terminus of human cytokeratin 6 protein.
E18402
0.5ml
Concentrate
human cytokeratin 8.
Application: IHC-P
E18404
1.0ml
Concentrate
Application: IHC-P
E18401
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18880
0.1ml
Concentrate
E18882
0.5ml
E18884
1.0ml
Concentrate
E18881
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Skin
Product Narrative: Cytokeratin 6 (CK6) and 16 (CK16) are expressed in keratinocytes,
which undergo rapid turnover in the suprabasal region. CK6 is found in basal cells of
prostate glands, hair follicles, suprabasal cells of a variety of internal stratified epithelia
and in epidermis. Epidermal injury results in activation of keratinocytes which express
CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell
carcinomas.
Product Narrative: Keratin 8 belongs to the type B (basic) subfamily of high molecular
weight keratins and exists in association with keratin 18. Keratin 8 is primarily found in
the non-squamous epithelia. It is present in hepatocellular carcinomas and the majority
of adenocarcinomas and ductal carcinomas, but it is absent in squamous
cell carcinomas.
Clone: SP52
Catalog No.
Size
Format
E3260
0.1ml
Concentrate
Concentrate
to C-terminus of human cytokeratin 7.
E3262
0.5ml
Concentrate
encoding aa 1-483 of human cytokeratin 8.
E3264
1.0ml
Concentrate
E3261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3520
0.1ml
Concentrate
M3522
0.5ml
M3524
1.0ml
Concentrate
M3521
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian
Carcinoma
Control Tissue: Breast Carcinoma, Lung, Skin
Membrane
Product Narrative: Cytokeratin 7 (CK7) is a basic cytokeratin which is found in most
glandular and transitional epithelia but not in the stratified squamous epithelia.
Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not in
colon, prostate, or gastrointestinal tract.
cell carcinomas.
Clone: SP102
Clone: N/A
Catalog No.
Size
Format
M4020
0.1ml
Concentrate
Concentrate
M4022
0.5ml
Concentrate
C-terminus of human keratin 8.
M4024
1.0ml
Concentrate
Application: IHC-P
M4021
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18000
0.1ml
Concentrate
E18002
0.5ml
E18004
1.0ml
Concentrate
E18001
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian
Carcinoma
Product Narrative: Cytokeratin 7 (CK7) is a basic cytokeratin which is found in most
glandular and transitional epithelia but not in the stratified squamous epithelia.
Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of
colon, prostate, or gastrointestinal tract.
70
cell carcinomas.
Primary Antibodies
Clone: N/A
Catalog No.
Size
Format
E2620
0.1ml
Concentrate
Concentrate
C-terminus of human keratin 10 protein.
E2622
0.5ml
Concentrate
Application: IHC-P
E2624
1.0ml
Concentrate
Application: IHC-P
E2621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18980
0.1ml
Concentrate
E18982
0.5ml
E18984
1.0ml
Concentrate
E18981
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Skin, Squamous Cell Carcinoma
Product Narrative: Cytokeratin 10 is a type I cytokeratin, expressed by suprabasal cells
of stratified and cornified epithelia. Its defects are implicated in bullous congenital
ichthyosiform erythroderma, epidermolytic hyperkeratosis and diffuse nonepidermolytic palomoplantar keratoderma.
Product Narrative: Cytokeratin 14 (CK14) belongs to the type A (acidic) subfamily of low
molecular weight keratins and exists in combination with cytokeratin 5.
Clone: SP99
Catalog No.
Size
Format
M3950
0.1ml
Concentrate
Concentrate
C-terminus of human keratin 10.
M3952
0.5ml
Concentrate
Application: IHC-P
M3954
1.0ml
Concentrate
M3951
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3990
0.1ml
Concentrate
M3992
0.5ml
M3994
1.0ml
Concentrate
M3991
7.0ml
Ready-to-Use
Clone: SP95
keratin 17 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: Cytokeratin 10 is a type I cytokeratin, expressed by suprabasal cells
of stratified and cornified epithelia. Its defects are implicated in bullous congenital
ichthyosiform erythroderma, epidermolytic hyperkeratosis and diffuse nonepidermolytic palomoplantar keratoderma.
Product Narrative: Cytokeratin 17 (CK17) plays a role in the formation and maintenance
of various skin appendages cytokeratin 17 is expressed in the outer root sheath and
medulla region of hair follicle from mucosal stratified squamous epithelia, basal cells
of oral epithelium, palmoplantar epidermis, and sweat and mammary glands. It is also
expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of
sebaceous gland and in exocervix.
Clone: SP53
Catalog No.
Size
Format
E18920
0.1ml
Concentrate
Concentrate
E18922
0.5ml
Concentrate
from C-terminus of cytokeratin 17 protein.
E18924
1.0ml
Concentrate
E18921
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3530
0.1ml
Concentrate
M3532
0.5ml
M3534
1.0ml
Concentrate
M3531
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Skin, Squamous
Cell Carcinoma
Control Tissue: Lung Carcinoma, Prostate
Carcinoma
Product Narrative: Cytokeratin 14 (CK14) belongs to the type A (acidic) subfamily of low
molecular weight keratins and exists in combination with cytokeratin 5.
Product Narrative: Cytokeratin 17 (CK17) plays a role in the formation and maintenance
of various skin appendages cytokeratin 17 is expressed in the outer root sheath and
medulla region of hair follicle from mucosal stratified squamous epithelia, basal cells
of oral epithelium, palmoplantar epidermis, and sweat and mammary glands. It is also
expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of
sebaceous gland and in exocervix.
71
Clone: SP69
Catalog No.
Size
Format
M4350
0.1ml
Concentrate
Concentrate
M4352
0.5ml
Concentrate
the C-terminus of human keratin 18 protein.
M4354
1.0ml
Concentrate
M4351
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3690
0.1ml
Concentrate
M3692
0.5ml
M3694
1.0ml
Concentrate
M3691
7.0ml
Ready-to-Use
Clone: SP135
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Liver
Human breast adenocarcinoma stained with
anti- keratin 18 antibody M369
Product Narrative: Cytokeratin 18 (CK18), which belongs to the type A (acidic) subfamily
of low molecular weight keratins exists in combination with cytokeratin 8. It was
reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and
18 but do not contain cytokeratin 14.
Product Narrative: Cytokeratin 18 (CK18) is an acidic keratin found primarily in simple
epithelium and is present in a majority of adenocarcniomas and ductal carcinomas
but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with a basic
keratin cytokeratin 8.
Keratin 18 Mouse Monoclonal
Clone: DC10
Catalog No.
Size
Format
E2630
0.1ml
Concentrate
Concentrate
Immunogen: Human breast cancer
PMC42 cells.
E2632
0.5ml
Concentrate
E2634
1.0ml
Concentrate
Application: IHC-P
E2631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17010
0.1ml
Concentrate
E17012
0.5ml
E17014
1.0ml
Concentrate
E17011
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Product Narrative: Cytokeratin 19 (CK19) is a member of type I acidic subfamily of
intermediate filaments. It is expressed in various different human tissues except in liver.
Cytokeratin 19 is not expressed in hepatocytes.
Clone: N/A
Catalog No.
Size
Format
M3330
0.1ml
Concentrate
Concentrate
to C-terminus of human cytokeratin 18
M3332
0.5ml
Concentrate
human cytokeratin 20.
M3334
1.0ml
Concentrate
Application: IHC-P
M3331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18330
0.1ml
Concentrate
E18332
0.5ml
E18334
1.0ml
Concentrate
E18331
7.0ml
Ready-to-Use
Clone: SP33
Isotype: Rabbit IgG
Isotype: Rabbit IgG
72
Product Narrative: Cytokeratin 20 (CK20) is a Type-I keratin primarily expressed in
gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in
adenocarcinomas of the colon, stomach, pancreas and the bile system, mucinous
ovarian tumors, transitional-cell, and Merkel-cell carcinomas. CK20 is negative in
squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium,
non-mucinous tumors of the ovary, and small cell carcinomas.
Primary Antibodies
KOC/L523S Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18310
0.1ml
Concentrate
Concentrate
E18312
0.5ml
Concentrate
internal region of human KOC/L523S.
Application: IHC-P
E18314
1.0ml
Concentrate
Application: IHC-P
E18311
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16440
0.1ml
Concentrate
E16442
0.5ml
E16444
1.0ml
Concentrate
E16441
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Prostate Carcinoma
anti-KOC/L523S antibody E1831
Product Narrative: Cytokeratin 20 (CK20) is a Type-I keratin primarily expressed in
gastric and intestinal epithelium, urothelium, and Merkel-cells. CK20 is expressed in
adenocarcinomas of the colon, stomach, pancreas and the bile system, mucinous
ovarian tumors, transitional-cell, and Merkel-cell carcinomas. CK20 is negative in
squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium,
non-mucinous tumors of the ovary, and small cell carcinomas.
Product Narrative: Insulin-like growth factor-II messenger RNA (mRNA)-binding
protein-3 (IMP-3), also known as K homology domain-containing protein (KOC), is
a member of the insulin-like growth factor-II mRNA-binding protein family and is
expressed in some malignancies such as melanoma but not in benign nevi. IMP-3 is
expressed in a significantly higher proportion of melanomas than Spitz nevi. IMP-3
appears to be involved in the progression of malignant melanoma.
Ki-67 Rabbit Monoclonal
k-Ras Rabbit Polyclonal
Clone: SP6
Catalog No.
Size
Format
E17960
0.1ml
Concentrate
Concentrate
human Ki-67 protein.
E17962
0.5ml
Concentrate
Immunogen: Synthetic peptide from internal region of
human k-Ras protein.
Application: IHC-P
E17964
1.0ml
Concentrate
Application: IHC-P
E17961
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3060
0.1ml
Concentrate
M3062
0.5ml
M3064
1.0ml
Concentrate
M3061
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Prostate Carcinoma
anti-Ki-67 antibody M306
anti-k-Ras antibody E1796
Product Narrative: Ki-67 is a nuclear protein which is expressed in the proliferating cells.
Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle,
while cells in the G0 (quiescent) phase are negative for this protein.
Product Narrative: The guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras)
cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine
kinases and G-protein-coupled receptors activate Ras. GTPase-activating proteins
(GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors,
point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most
common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D).
Ki-67 Rabbit Polyclonal
Ku80 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4300
0.1ml
Concentrate
Concentrate
human Ki-67 protein.
M4302
0.5ml
Concentrate
Application: IHC-P
M4304
1.0ml
Concentrate
M4301
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E1870
0.1ml
Concentrate
E1872
0.5ml
E1874
1.0ml
Concentrate
E1871
7.0ml
Ready-to-Use
Clone: SP130
corresponding to an internal region of human
Ku80 protein.
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Lymph Node, Tonsil
Isotype: Rabbit IgG
anti-Ki-67 antibody E187
Product Narrative: Ki-67 is a nuclear protein which is expressed in the proliferating cells.
Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle,
while cells in the G0 (quiescent) phase are negative for this protein.
anti-Ku80 antibody M430
Product Narrative: X-ray repair cross-complementing protein 5 (XRCC5), alternative
name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in
chromosome translocation. Ku80 is widely expressed nuclear protein that binds to and
stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition
of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the
killing of cancer cells, and reduce drug resistance.
73
Ku80 Rabbit Polyclonal
Lambda Light Chain Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E19200
0.1ml
Concentrate
Concentrate
C-terminus of human Ku80 protein.
E19202
0.5ml
Concentrate
Immunogen: Free lambda light chain from
Application: IHC-P
E19204
1.0ml
Concentrate
E19201
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19110
0.1ml
Concentrate
E19112
0.5ml
E19114
1.0ml
Concentrate
E19111
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-Ku80 antibody E1911
anti-Lambda Light Chain antibody E1920
name (Ku80), is a single stranded DNA-dependent ATP-dependent helicase. Ku80, along
with Ku70 forms a heterodimeric protein and Ku80 is a widely expressed nuclear protein
that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA
breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and
potentially increase the killing of cancer cells.
Product Narrative: Lambda light chains are polypeptide chains located in the cell
membrane and cytoplasmic regions of normal B cells and plasma cells. The combination
of lambda light chains and heavy chains forms immunoglobulin molecules. There are
two classes of light chains found in immunoglobulins: kappa light chains and lambda
light chains. Light chain production by lymphoid cells is genetically restricted to single
light chain class.
Ku80 Rabbit Polyclonal
Lamin B Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13490
0.1ml
Concentrate
Concentrate
region of human Ku80 protein.
E13492
0.5ml
Concentrate
to C-terminus of human lamin B.
Application: IHC-P
E13494
1.0ml
Concentrate
E13491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19120
0.1ml
Concentrate
E19122
0.5ml
E19124
1.0ml
Concentrate
E19121
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Cellular Localization: Nucleus Envelope
anti-Ku80 antibody E1912
anti-lamin B antibody E1349
name (Ku80), is a single stranded DNA-dependent ATP-dependent helicase. Ku80, along
with Ku70 forms a heterodimeric protein and Ku80 is a widely expressed nuclear protein
that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA
breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and
potentially increase the killing of cancer cells.
Product Narrative: Nuclear lamins form a network of filaments at the nucleoplasmic site
of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished,
i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins
arising from the same gene by alternative splicing: lamin A, lamin C and lamin Adel10.
While the B-type lamins include two proteins arising from two distinct genes: lamin B1
and lamin B2.
Lambda Light Chain** Rabbit Monoclonal
Lewis A Mouse Monoclonal
Clone: SP147
Catalog No.
Size
Format
E17380
0.1ml
Concentrate
Immunogen: Mucin isolated from an ovarian cyst.
Concentrate
Immunogen: Free lambda light chain from
E17382
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
E17384
1.0ml
Concentrate
7.0ml
Ready-to-Use
E17381
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4470
0.1ml
Concentrate
M4472
0.5ml
M4474
M4471
Clone: SPM522
Isotype: Mouse IgG1
Isotype: Rabbit IgG
anti-lambda light chain antibody M447
Product Narrative: Lambda light chains are polypeptide chains located in the cell
membrane and cytoplasmic regions of normal B cells and plasma cells. Light chain
production is genetically restricted to a single light chain class for a given lymphoid cell.
This clonal restriction may be used to indicate the polyclonal or monoclonal nature of B
cell and plasma cell populations. The level of lambda can be greatly elevated in multiple
myeloma or other B cell malignancies.
74
anti-Lewis A antibody E1738
Product Narrative: Lewis A is a blood group antigen consisting of Gal Beta1-3 (Fuc
alpha1-4) GlcNAc. Lewis A is found to be present primarily on epithelial cells such as
colon and kidneys.
Primary Antibodies
LIMD1 Rabbit Polyclonal
LMO2 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E17650
0.1ml
Concentrate
Concentrate
N-terminus of human LIMD1 protein.
E17652
0.5ml
Concentrate
human LMO2 protein.
Application: IHC-P
E17654
1.0ml
Concentrate
Application: IHC-P
E17651
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18700
0.1ml
Concentrate
E18702
0.5ml
E18704
1.0ml
Concentrate
E18701
7.0ml
Ready-to-Use
Clone: 1A9-3D11
Isotype: Rabbit IgG
Isotype: Mouse IgG1
anti-LIMD1 antibody E1870
anti-LMO2 antibody E1765
Product Narrative: The Zyxin family of proteins contains five members: Ajuba, LIMD1,
LPP, TRIP6 and Zyxin. LIMD1 is a ubiquitously expressed tumor suppressor. LIM domains
consist of a cysteine-rich consensus sequence containing two distinct zinc-binding
subdomains, which mediate protein-protein interactions. LIMD1 was first identified
when the deletion of its gene was noted in some cervical cancers. LIMD1 blocks tumor
growth and is downregulated in lung cancer.
Product Narrative: LMO-2 encodes a cysteine-rich, two LIM-domain protein that is
required for yolk sac erythropoiesis. The LMO-2 protein has a central and crucial role in
hematopoietic development and is highly conserved. The LMO-2 transcription start site
is located approximately 25 kb downstream from the 11p13 T cell translocation cluster
(11p13 ttc), where T cell acute lymphoblastic leukemia-specific translocations occur.
Lipocalin-2 Rabbit Polyclonal
LMO2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17830
0.1ml
Concentrate
Concentrate
N-terminus of human lipocalin-2 protein.
E17832
0.5ml
Concentrate
human LMO2 protein.
Application: IHC-P
E17834
1.0ml
Concentrate
Application: IHC-P
E17831
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18810
0.1ml
Concentrate
E18812
0.5ml
E18814
1.0ml
Concentrate
E18811
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Stomach Carcinoma
Human stomach adenocarcinoma stained with
anti-lipocalin-2 antibody E1881
anti-LMO2 antibody E1783
Product Narrative: Lipocalin 2 is a member of the lipocalin family which encompass
more than 25 members (including proteins like retinol binding protein, a1
microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The
members of the lipocalin family are characterized by their ability to bind small lipophilic
substances in their hydrophobic core, and thereby serve as transporters of substances.
LMO2** Rabbit Monoclonal
Luteinizing Hormone (LH) Rabbit Monoclonal
Catalog No.
Size
Format
M3510
0.1ml
Concentrate
M3512
0.5ml
Concentrate
M3514
1.0ml
Concentrate
M3511
7.0ml
Ready-to-Use
Clone: SP51
Catalog No.
Size
Format
corresponding to near N-terminus of human
LMO2 protein.
M4320
0.1ml
Concentrate
Immunogen: Recombinant human LH protein.
M4322
0.5ml
Concentrate
Application: IHC-P
M4324
1.0ml
Concentrate
M4321
7.0ml
Ready-to-Use
Clone: SP132
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-LMO2 antibody M351
anti-LH antibody M432
Product Narrative: Luteinizing hormone (LH, also known as lutropin) is a tropic hormone
which modulates the secretory activity of other endocrine glands. It is produced in the
anterior hypophysis of the pituitary gland. The glycoprotein hormone, LH, like follicle
stimulating hormone and thyroid stimulating hormone, is composed of a common
alpha-subunit but also a specific beta-subunit, which characterizes each of these
hormones.
75
Luteinizing Hormone (LH) Rabbit Polyclonal
MAP4K4 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human luteinizing hormone.
M4770
0.1ml
Concentrate
Concentrate
Application: IHC-P
M4772
0.5ml
Concentrate
C-terminus of human MAP4K4 protein.
M4774
1.0ml
Concentrate
Application: IHC-P
M4771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17480
0.1ml
E17482
0.5ml
E17484
1.0ml
Concentrate
E17481
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: SP177
Isotype: Rabbit IgG
Control Tissue: Prostate Adenocarcinoma
anti-luteinizing hormone (LH) antibody E1748
anti- MAP4K4 antibody M477
Product Narrative: LH is a tropic hormone which modulates the secretory activity of
other endocrine glands. It is produced in the anterior hypophysis of the pituitary gland.
The glycoprotein hormone, LH, like follicle stimulating hormone and thyroid stimulating
hormone, is composed of a common alpha-subunit but also a specific beta-subunit,
which characterizes each of these hormones.
Product Narrative: Mitogen-activated protein kinase kinase kinase 4 (MAP4K4) is a
member of stress activated MAP kinase signaling pathway. It directly phosphorylates
and activates the c-Jun N-terminal kinase (JNK) and p38 families of MAP kinases in
response to various stimulating factors. It involves the mediation of TNF-alpha signaling
pathway. MAP4K4 is overexpressed in many types of human cancer such as carcinoma of
prostate, ovarian, liver, and pancreas.
MAGE-1 Rabbit Polyclonal
MART-1/Melan-A Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2830
0.1ml
Concentrate
Immunogen: Recombinant human MART-1 protein.
Concentrate
MAGE-1 protein.
E2832
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E2834
1.0ml
Concentrate
7.0ml
Ready-to-Use
E2831
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4500
0.1ml
Concentrate
E4502
0.5ml
E4504
E4501
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Melanoma, Testis
anti-MAGE-1 antibody E450
anti-MART-1 antibody E283
Product Narrative: Melanoma-associated antigen 1 (MAGE-1) genes encode an
important group of antigens. MAGE-1 is expressed on a significant proportion of human
neoplasms such as melanoma, brain glial tumors, neuroblastoma, non-small cell lung
cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas, but not on kidney
tumor, leukemias and lymphomas.
Product Narrative: MART-1 / Melan-A is a melanocyte differentiation antigen recognized
by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens
recognized by autologous cytotoxic T cells include MAGE-1, MAGE-1 tyrosinase, gp100,
gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in
melanosomes and endoplasmic reticulum.
MALT-1 Rabbit Polyclonal
MCL-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2640
0.1ml
Concentrate
Concentrate
internal region of human MALT-1 protein.
E2642
0.5ml
Concentrate
region of human MCL-1.
E2644
1.0ml
Concentrate
Application: IHC-P
E2641
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18900
0.1ml
Concentrate
E18902
0.5ml
E18904
1.0ml
Concentrate
E18901
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma,
Lymph Node, Tonsil
anti-MALT-1 antibody E1890
Product Narrative: Mucosa-associated lymphoid tissue lymphoma translocation protein
1 (MALT-1) has two alternatively spliced transcript variants encoding different isoforms.
Isoform a is protein of 824 amino acids, and isoform b is a protein of 813 amino acids.
MALT-1 is thought to play a role in NF kappaB signaling by enchancing NF kappaB
activation through interaction with BCL-10. Interaction between MALT-1 and BCL-10
mediates IKK activation in vitro.
76
anti-MCL-1 antibody E264
Product Narrative: Myeloid cell leukemia-1 (MCL-1) is a member of the BCL-2 family. The
carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression
of MCL-1 is increased upon exposure of ML-1 cells to ionizing radiation, ultraviolet
radiation, and alkylating drugs along with increases in GADD45 and Bax and a decrease
in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions
that otherwise cause apoptosis.
Primary Antibodies
MCM2 Rabbit Monoclonal
Catalog No.
Size
Format
M3850
0.1ml
Concentrate
M3852
0.5ml
Concentrate
M3854
1.0ml
Concentrate
M3851
7.0ml
Ready-to-Use
MCM5 Rabbit Polyclonal
Clone: SP85
Catalog No.
Size
Format
from internal region of human MCM2
protein.
E13830
0.1ml
Concentrate
Clone: N/A
E13832
0.5ml
Concentrate
aa 1-150 of human MCM5.
E13834
1.0ml
Concentrate
Application: IHC-P
E13831
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Human rectal carcinoma stained with
anti-MCM2 antibody M385
anti-MCM-5 antibody E1383
Product Narrative: The mini-chromosome maintenance (MCM) family of proteins,
including MCM2, MCM3, MCM4(CDC21), MCM5(CDC46), MCM6(Mis5) and
MCM7(CDC47), are regulators of DNA replication that act to ensure replication occurs
only once in the cell cycle. Expression of MCM proteins increases during cell growth,
peaking at G1 to S phase. MCM2/MCM4 complexes function as substrates for CDC2/
cyclin B in vitro.
Product Narrative: MCM5 (Mini Chromosome Maintainance protein-5) is involved in
the control of DNA replication. MCM proteins have DNA dependent ATPase motifs in
their central domain which is conserved from yeast to mammals. MCM proteins form
a complex which exhibits ATPase and helicase activities. G0 phase levels of MCM2 and
MCM5 are lower than that of MCM7 and MCM3 but increase as the cell enters G1/S
phase of the cell cycle.
MDGI Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18670
0.1ml
Concentrate
Concentrate
N-terminus of human MCM2 protein.
E18672
0.5ml
Concentrate
region of human MDGI protein.
Application: IHC-P
E18674
1.0ml
Concentrate
Application: IHC-P
E18671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12480
0.1ml
Concentrate
E12482
0.5ml
E12484
1.0ml
Concentrate
E12481
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-MCM2 antibody E1248
anti-MDGI antibody E1867
cyclin B in vitro.
Product Narrative: MDGI/FABP3 is a small cytosolic protein responsible for the transport
and deposition of fatty acids inside the cell.
MDGI Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18620
0.1ml
Concentrate
Concentrate
region of human MCM2 protein.
E18622
0.5ml
Concentrate
N-terminus of human MDGI protein.
Application: IHC-P
E18624
1.0ml
Concentrate
Application: IHC-P
E18621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18730
0.1ml
Concentrate
E18732
0.5ml
E18734
1.0ml
Concentrate
E18731
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Human rectal adenocarcinoma stained with
anti-MCM2 antibody E1873
anti-MDGI antibody E1862
cyclin B in vitro.
Product Narrative: MDGI/FABP3 is a small cytosolic protein responsible for the transport
and deposition of fatty acids inside the cell.
77
MEF-2 Rabbit Polyclonal
Mesothelin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18390
0.1ml
Concentrate
Concentrate
aa 487-507 of human MEF-2.
E18392
0.5ml
Concentrate
human mesothelin.
Application: IHC-P
E18394
1.0ml
Concentrate
Application: IHC-P
E18391
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12390
0.1ml
Concentrate
E12392
0.5ml
E12394
1.0ml
Concentrate
E12391
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-MEF-2 antibody E1239
anti-mesothelin antibody E1839
Product Narrative: The myocyte enhancer factors-2 (MEF-2) family of transcription
factors associate with a variety of co-repressors or co-activators to regulate development
and function of T cells, neuronal cells, and muscle cells. Four distinct family members
arise from alternatively splices transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF2D. These members bind as homo- and heterodimers to the MEF2 site in the promoter
region of affected genes.
Product Narrative: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface
glycoprotein that is present on the surface of normal mesothelium and is overexpressed
in epithelial ovarian cancer and malignant mesotheliomas.
Melanoma (gp100) Rabbit Polyclonal
mGluR1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2890
0.1ml
Concentrate
Concentrate
human gp100.
E2892
0.5ml
Concentrate
human mGluR1.
Application: IHC-P
E2894
1.0ml
Concentrate
Application: IHC-P
E2891
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4450
0.1ml
Concentrate
E4452
0.5ml
E4454
1.0ml
Concentrate
E4451
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-melanoma gp100 antibody E445
anti-GluR1 antibody E289
Product Narrative: By immunohistochemistry, this antibody specifically recognizes a
protein in melanocytes and melanomas. Intradermal nevi, normal adult melanocytes,
and non-melanocytic cells are negative. It does not stain tumor cells of epithelial,
lymphoid, glial, or mesenchymal origin.
complexes of various subunits (GluR1-7, NMDA1-3, KAI-2) which comprise ligand-gated
calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors,
which when activated can activate phopholipases or adenylylcyclase.
Mesothelin Rabbit Monoclonal
mGluR5 Rabbit Polyclonal
Clone: SP74
Catalog No.
Size
Format
E2870
0.1ml
Concentrate
Concentrate
C-terminus of human mesothelin protein.
E2872
0.5ml
Concentrate
human mGluR5.
Application: IHC-P
E2874
1.0ml
Concentrate
Application: IHC-P
E2871
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3740
0.1ml
Concentrate
M3742
0.5ml
M3744
1.0ml
Concentrate
M3741
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-mesothelin antibody M374
anti-mGluR5 antibody E287
Product Narrative: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface
glycoprotein that is present on the surface of normal mesothelium and is overexpressed
in epithelial ovarian cancer and malignant mesotheliomas.
78
Clone: N/A
complexes of various subunits (GluR1-7, NMDA1-3, KAI-2) which comprise ligand-gated
calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors,
which when activated can activate phopholipases or adenylylcyclase.
Primary Antibodies
Microphthalmia (MiTF) Rabbit Polyclonal
MMP-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3570
0.1ml
Concentrate
Concentrate
human MiTF.
E3572
0.5ml
Concentrate
Immunogen: Synthetic peptide from near C-terminus of
human MMP-1 protein.
Application: IHC-P
E3574
1.0ml
Concentrate
Application: IHC-P
E3571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17900
0.1ml
Concentrate
E17902
0.5ml
E17904
1.0ml
Concentrate
E17901
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Ovarian Carcinoma,
Placenta
anti-MITF antibody E1790
anti-MMP-1 antibody E357
Product Narrative: Microphthalmia associated transcription factor (MiTF) is a basic helixloop-helix leucine zipper transcription factor implicated in pigmentation, mast cells
and bone development. There are two known isoforms of MiTF. The shorter forms are
expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer
Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells,
as well as mast cells and heart.
Product Narrative: Matrix metalloproteinases (MMP) are proteolytic enzymes capable
of degrading connective tissue components. Imbalanced secretion of certain MMP
or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs)
is implicated in the invasive potential of tumors. MMP-1, MMP2, and MMP-9 dissolve
extracellular matrix (ECM) and may initiate and promote angiogenesis.
MIP-1 alpha Rabbit Polyclonal
MMP-2 (72kDa Collagenase IV) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18010
0.1ml
Concentrate
Concentrate
internal region of human MIP-1 alpha.
E18012
0.5ml
Concentrate
N-terminus of human MMP-2 protein.
Application: IHC-P
E18014
1.0ml
Concentrate
Application: IHC-P
E18011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12680
0.1ml
Concentrate
E12682
0.5ml
E12684
1.0ml
Concentrate
E12681
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Ovarian Carcinoma,
Placenta
anti-MIP-1 alpha antibody E1268
Product Narrative: Macrophage inflammatory protein-1a (MIP-1a) is an 8kDa member of
the C-C chemokine subfamily. C-C chemokines are chemoattractants and activators for
monocytes and T cells. MIP-1a has been identified as one of the major HIV-SFs produced
by CD8+ T cells, along with MIP-1b and RANTES.
Product Narrative: MMPs are proteolytic enzymes capable of degrading connective
tissue components. They have a common mode of activation, a conserved amino acid
sequence in the putative metal-binding active site region, and are inhibited by specific
tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in
regulating angiogenesis. MMP-2 is activated by cleavage of the first 80 amino acids. This
antibody reacts with both latent and active MMP-2.
MLH1 Rabbit Polyclonal
MMP-3 (Stromelysin-1) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12670
0.1ml
Concentrate
Concentrate
internal region of human MLH1 protein.
E12672
0.5ml
Concentrate
aa 251-478 of human MMP-3.
Application: IHC-P
E12674
1.0ml
Concentrate
Application: IHC-P
E12671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17810
0.1ml
Concentrate
E17812
0.5ml
E17814
1.0ml
Concentrate
E17811
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Rectal Carcinoma
anti-MLH1 antibody E1781
Product Narrative: MUTL protein homolog 1 (MLH1) is a DNA mismatch repair protein.
The repair of mismatch DNA is essential to maintain the integrity of genetic information.
An alteration of microsatellite repeats due to strand misalignment during DNA
replication is referred to as microsatellite instability (MSI). These defects in DNA repair
pathways have been related to human carcinogenesis.
Product Narrative: Matrix metalloproteinases (MMP) are proteolytic enzymes capable
of degrading connective tissue components. Imbalanced secretion of certain MMP or
disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is
implicated in the invasive potential of malignant tumors. Stromelysin (MMP3/Transin)
degrades several matrix components including the core proteins of proteoglycans,
laminin and non-helical regions of collagens.
79
MMP-9 (92kDa Collagenase IV) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4030
0.1ml
Concentrate
Concentrate
C-terminus of humtan MMP-9 protein.
E4032
0.5ml
Concentrate
Application: IHC-P
E4034
1.0ml
Concentrate
Application: IHC-P
E4031
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3660
0.1ml
Concentrate
E3662
0.5ml
E3664
1.0ml
Concentrate
E3661
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
sequence in the putative metal binding-active site region, and are inhibited by specific
regulating angiogenesis. This antibody reacts with both latent and active MMP-9.
regulating angiogenesis. MMP-19 is the target of autoantibodies in rheumatoid arthritis
and SLE.
MMP-14/MT1-MMP Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4040
0.1ml
Concentrate
Concentrate
region of human MMP-14 protein.
E4042
0.5ml
Concentrate
Application: IHC-P
E4044
1.0ml
Concentrate
Application: IHC-P
E4041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3860
0.1ml
Concentrate
E3862
0.5ml
E3864
1.0ml
Concentrate
E3861
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: MMPs are a group of enzymes involved in matrix degradation. MT1MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively, contain
a C-terminus transmembrane domain anchoring them to the cell surface. They have an
8 amino acid insert in their catalytic domain. MMP-14 cleaves progelatinase A (MMP-2)
and progelatinase B to their active forms and it gets activated through the membrane
plasmin cascade.
tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play a significant role in
regulating angiogenesis. MMP-23 transcripts have been detected in reproductive organs
like ovary, testis and prostate. MMP-23 is inhibited by TIMP-1.
MMP-15/MT2-MMP Rabbit Polyclonal
MSH2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3460
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide from the catalytic
domain of mouse MMP-15/MT2-MMP protein.
M3462
0.5ml
Concentrate
internal region of human MSH2.
Application: IHC-P
M3464
1.0ml
Concentrate
Application: IHC-P
M3461
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4120
0.1ml
Concentrate
E4122
0.5ml
E4124
1.0ml
Concentrate
E4121
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-MSH2 antibody M346
Product Narrative: MMPs are a group of enzymes involved in matrix degradation. MT1MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain
a C-terminus transmembrane domain anchoring them to the cell surface. MMP15 plays
a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. MMP14
and MMP15 can be coexpressed in advanced stages of breast carcinoma.
80
Clone: SP46
Product Narrative: MSH2 as a mismatch repair protein is involved in DNA repair.
Mutations of MSH2 are found in approximately 50% of inherited non polyposis
colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal,
dominantly inherited disease associated with marked increase in cancer susceptibility.
It is characterized by a familial predisposition to early onset colorectal carcinoma and
cancers of the gastrointestinal, urological and female reproductive tracts.
Primary Antibodies
MSH2 Rabbit Polyclonal
MSH6 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E18370
0.1ml
Concentrate
Concentrate
internal region of human MSH2.
E18372
0.5ml
Concentrate
internal region of human MSH6 protein.
Application: IHC-P
E18374
1.0ml
Concentrate
Application: IHC-P
E18371
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17790
0.1ml
Concentrate
E17792
0.5ml
E17794
1.0ml
Concentrate
E17791
7.0ml
Ready-to-Use
Clone: SPM525
Isotype: Rabbit IgG
anti-MSH2 antibody E1779
Product Narrative: MSH2 as a mismatch repair protein is involved in DNA repair.
Mutations of MSH2 are found in approximately 50% of inherited non polyposis
colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal,
dominantly inherited disease associated with marked increase in cancer susceptibility.
It is characterized by a familial predisposition to early onset colorectal carcinoma and
cancers of the gastrointestinal, urological and female reproductive tracts.
Product Narrative: MSH6 as a mismatch repair protein is central to mismatch DNA
repair. Mutations of MSH6 are found in inherited non polyposis colorectal carcinoma
(HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease
associated with marked increase in cancer susceptibility. It is characterized by a familial
predisposition to early onset colorectal carcinoma and cancers of the gastrointestinal,
urological and female reproductive tracts.
Clone: N/A
Catalog No.
Size
Format
E17670
0.1ml
Concentrate
Concentrate
region of human MSH3 protein.
E17672
0.5ml
Concentrate
internal region of human MSH6 protein.
Application: IHC-P
E17674
1.0ml
Concentrate
Application: IHC-P
E17671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18940
0.1ml
Concentrate
E18942
0.5ml
E18944
1.0ml
Concentrate
E18941
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Product Narrative: MSH3 belongs to the MutS DNA mismatch repair family although its
precise function in mammals is still unknown. Yeast MSH3 is thought to act in a complex
with MSH2 to recognize DNA insertion/deletion mispairs.
MSH6 Rabbit Monoclonal
mTOR Rabbit Polyclonal
Catalog No.
Size
Format
M3930
0.1ml
Concentrate
M3932
0.5ml
Concentrate
M3934
1.0ml
Concentrate
M3931
7.0ml
Ready-to-Use
Clone: SP93
Catalog No.
Size
Format
corresponding to internal region of human
MSH6 protein.
E18450
0.1ml
Concentrate
Clone: N/A
E18452
0.5ml
Concentrate
human mTOR.
E18454
1.0ml
Concentrate
Application: IHC-P
E18451
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-MSH6 antibody M393
anti-mTOR antibody E1845
Product Narrative: Mammalian target of rapamycin (mTOR) or FKBP12-rapamycin
associated protein (FRAP) is a serine/threonine-protein kinase involved in cell cycle
progression, DNA recombination, and DNA damage detection. The MTOR-rapamycin
complex is known to inhibit progression through the G1 cell cycle stage by interfering
with mitogenic signaling pathways. The binding of FRAP to FKBP12-rapamycin is
correlated with the ability of these ligands to inhibit cell cycle progression.
81
mTOR Rabbit Polyclonal
MUC-1/EMA/Epithelial Membrane Antigen Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3540
0.1ml
Concentrate
Concentrate
C-terminus of human mTOR protein.
E3542
0.5ml
Concentrate
Immunogen: Synthetic peptide from the cytoplasmic
tail of human MUC-1.
Application: IHC-P
E3544
1.0ml
Concentrate
Application: IHC-P
E3541
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18590
0.1ml
Concentrate
E18592
0.5ml
E18594
1.0ml
Concentrate
E18591
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-mTOR antibody E1859
anti-MUC-1 antibody E354
Product Narrative: Mammalian target of rapamycin (mTOR) or FKBP12-rapamycin
associated protein (FRAP) is a serine/threonine-protein kinase involved in cell cycle
progression, DNA recombination, and DNA damage detection. The MTOR-rapamycin
complex is known to inhibit progression through the G1 cell cycle stage by interfering
with mitogenic signaling pathways. The binding of FRAP to FKBP12-rapamycin is
correlated with the ability of these ligands to inhibit cell cycle progression.
Product Narrative: MUC-1 is a heavily O-glycosylated transmembrane protein expressed
on most secretory epithelium, including mammary gland and some hematopoietic cells.
It is expressed abundantly in lactating mammary glands and overexpressed abundantly
in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to
associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
MUC-1 Underglycosylated Mouse Monoclonal
Mucin 5AC Mouse Monoclonal
Clone: SPM493
Catalog No.
Size
Format
Concentrate
Immunogen: Human breast cell line ZR-75-1.
E11080
0.1ml
Concentrate
Concentrate
E11082
0.5ml
Concentrate
Immunogen: M1 mucin preparation from the fluid of an
ovarian mucinous cyst.
E11084
1.0ml
Concentrate
Application: IHC-P
E11081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11200
0.1ml
E11202
0.5ml
E11204
1.0ml
Concentrate
E11201
7.0ml
Ready-to-Use
Clone: 45M1
Membrane
anti-Muc5AC antibody E1108
Product Narrative: Epithelial membrane antigen (EMA), or CA15-3, or polymorphic
epithelial mucin (PEM), or sialomucin, or episialin, is a mucin-like glycoprotein. This
antibody stains an underglycosylated MUC1 often present on carcinoma cells.
Product Narrative: Mucins are high molecular weight glycoproteins with 80%
carbohydrate contents and the remaining 20% is constituted by protein core. Gastric
mucin is found in normal human gastrointestinal tract. Resurgence of gastric mucin
reactivity during colonic carcinogenesis is due to re-expression of the peptide core of
gastric (or fetal colonic) mucins.
MUC-1/EMA/Epithelial Membrane Antigen Mouse Monoclonal
Mucin-2/MUC-2 Mouse Monoclonal
Clone: SPM492
Catalog No.
Size
Format
Concentrate
Immunogen: Human breast cell line ZR-75-1.
E16560
0.1ml
Concentrate
Concentrate
Application: IHC-P
E16562
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to a site
on the MUC-2 glycoprotein.
E16564
1.0ml
Concentrate
Application: IHC-P
E16561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E11190
0.1ml
E11192
0.5ml
E11194
1.0ml
Concentrate
E11191
7.0ml
Ready-to-Use
Clone: SPM512
Isotype: Mouse IgG1
Product Narrative: MUC-1 is a heavily O-glycosylated transmembrane protein expressed
on most secretory epithelium, including mammary gland and some hematopoietic cells.
It is expressed abundantly in lactating mammary glands and overexpressed abundantly
in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to
associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
82
Product Narrative: Secreted epithelial mucins are large macromolecules which exhibit
extreme polydispersity. Mucin-2 is the major intestinal mucin. O-glycans are attached
to MUC-2 in a potentially diverse arrangement, which is crucial for their interaction with
endogeneous and exogeneous lectins.
Primary Antibodies
MUM1/IRF4 Rabbit Monoclonal
Myeloperoxidase (MPO) Rabbit Polyclonal
Clone: SP114
Catalog No.
Size
Format
E17710
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near
C-terminus of human MUM1/IRF4.
E17712
0.5ml
Concentrate
C-terminus of human myeloperoxidase protein.
E17714
1.0ml
Concentrate
Application: IHC-P
E17711
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4140
0.1ml
Concentrate
M4142
0.5ml
M4144
1.0ml
Concentrate
M4141
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lymph Node, Spleen, Tonsil
Molecular Weight: ~51.7 kDa
anti-Mum1/IRF4 antibody M414
Human lymph node stained with
anti-myeloperoxidase antibody E1771
Product Narrative: The MUM1 (Multiple Myeloma Oncogene 1) gene was originally
identified because of its involvement in the t(6;14) translocation observed in multiple
myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus.
MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and
extra-hematopoitic tumors. It is an excellent marker for Reed-Sternberg cells of classic
Hodgkin’s disease.
Product Narrative: Myeloperoxidase (MPO) is an important enzyme used
by granulocytes during phagocytic lysis. In normal tissues and in a variety of
myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types
exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes,
lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is postive in myeloid,
but negative in lymphoid leukemias.
MUM1/IRF4 Rabbit Polyclonal
Myoglobin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2990
0.1ml
Concentrate
Immunogen: Purified human myoglobin.
Concentrate
aa 144-451 of human MUM1 protein.
E2992
0.5ml
Concentrate
1.0ml
Concentrate
Application: IHC-P
E2994
1.0ml
Concentrate
7.0ml
Ready-to-Use
E2991
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18350
0.1ml
Concentrate
E18352
0.5ml
E18354
E18351
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-MUM1 antibody E1835
anti-myoglobin antibody E299
Product Narrative: The MUM1 (Multiple Myeloma Oncogene 1) gene was originally
identified because of its involvement in the t(6;14) translocation observed in multiple
myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus.
MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid
and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and
characterizing histogenesis of B-cell lymphomas.
Product Narrative: Myoglobin is a cytoplasmic, single chain polypeptide of 153 amino
acids and contains a single heme group. Myoglobin is found in skeletal and cardiac
muscle but not in smooth muscle and functions as an oxygen transporting pigment.
Upon damage to the muscle cell due to infarction of a coronary artery, neurological
trauma, infection of tumor processes, myoglobin escapes to the environment.
Myeloperoxidase (MPO) Rabbit Monoclonal
NCK2 Rabbit Polyclonal
Clone: SP72
Catalog No.
Size
Format
E11040
0.1ml
Concentrate
Concentrate
C-terminus of human myeloperoxidase protein.
E11042
0.5ml
Concentrate
aa 119-276 of human NCK2.
Application: IHC-P
E11044
1.0ml
Concentrate
Application: IHC-P
E11041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3720
0.1ml
Concentrate
M3722
0.5ml
M3724
1.0ml
Concentrate
M3721
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Human Tonsil stained with
anti-Myeloperoxidase (MPO) antibody M372
anti-NCK2 antibody E1104
Product Narrative: Myeloperoxidase (MPO) is an important enzyme used
by granulocytes during phagocytic lysis. In normal tissues and in a variety of
myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types
exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes,
lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is postive in myeloid,
but negative in lymphoid leukemias.
Product Narrative: The NCK family of SH2/SH3 adaptor proteins consists of two
members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF
and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds
human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane
ruffling and lamellipod formation.
83
Negative Control for Rabbit IgG Rabbit Monoclonal
Nestin Rabbit Polyclonal
Clone: SP137
Catalog No.
Size
Format
Concentrate
Immunogen: N/A
E18750
0.1ml
Concentrate
Concentrate
Application: IHC-P
E18752
0.5ml
Concentrate
region of human nestin protein.
Species Reactivity*: N/A
E18754
1.0ml
Concentrate
Application: IHC-P
E18751
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4370
0.1ml
M4372
0.5ml
M4374
1.0ml
Concentrate
M4371
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Control Tissue: N/A
Isotype: Rabbit IgG
N/A M437
anti-nestin antibody E1875
Product Narrative: The Negative Control is a recombinant rabbit monoclonal antibody
against a small molecule, which is normally not present in human or animal. The product
will not cross-react with human tissues when used at the recommended concentration.
Product Narrative: Nestin is a class VI intermediate filament expressed in the developing
central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein
has been widely used as a predominant marker for stem / progenitor cells, glioma
cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior
angiogenic marker to evaluate neovascularity of endothelial cells in tumor.
Nephrin Rabbit Polyclonal
Nestin Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4030
0.1ml
Concentrate
Concentrate
internal region of human nephrin.
M4032
0.5ml
Concentrate
Application: IHC-P
M4034
1.0ml
Concentrate
Species Reactivity*: Htuman
M4031
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18160
0.1ml
Concentrate
E18162
0.5ml
E18164
1.0ml
Concentrate
E18161
7.0ml
Ready-to-Use
Clone: SP103
corresponding to C-terminus of
human nestin.
Isotype: Rabbit IgG
Control Tissue: Kidney
Isotype: Rabbit IgG
Control Tissue: Kidney
anti-nephrin antibody E1816
anti-nestin antibody. M403
Product Narrative: Nephrin, a cell adhesion molecule, may play a crucial role in
maintaining the glomerular filtration barrier. Three novel podocyte proteins, podocin,
nephrin and alpha actinin 4 have been identified. The role of nephrin in anti-apoptotic
activity in podocyte is believed to be associated with vascular endothelial derived
growth factors VEGF signaling. Nephrin seems to play a role in the development or
function of the kidney glomerular filtration barrier.
Nestin Rabbit Polyclonal
Neuron Specific Enolase (NSE) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3300
0.1ml
Concentrate
Concentrate
C-terminus of human nestin protein.
E3302
0.5ml
Concentrate
C-terminus of human NSE.
Application: IHC-P
E3304
1.0ml
Concentrate
Application: IHC-P
E3301
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18610
0.1ml
Concentrate
E18612
0.5ml
E18614
1.0ml
Concentrate
E18611
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Kidney, Liver Carcinoma
Human liver hepatoma stained with
anti-nestin antibody E1861
anti-NSE antibody E330
84
Clone: N/A
Product Narrative: Enolase is a glycolytic enzyme catalyzing the reaction pathway
between 2-phospho-glycerate and phosphoenol pyruvate. In mammals, enolase
molecules are dimers composed of three distinct subunits (α,β and γ). The alpha-subunit
is expressed in most tissues and the beta-subunit only in muscle. The gamma-subunit
is expressed primarily in neurons, in normal and in neoplastic neuroendocrine cells.
Coexpression of NSE and chromogranin A is common in neuroendocrine neoplasms.
Primary Antibodies
NFkB p50 Rabbit Polyclonal
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4260
0.1ml
Concentrate
Concentrate
human NFκB p50.
M4262
0.5ml
Concentrate
Immunogen: Synthetic peptide near the C-terminus of
mouse iNOS protein.
Application: IHC-P
M4264
1.0ml
Concentrate
Application: IHC-P
M4261
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3630
0.1ml
Concentrate
E3632
0.5ml
E3634
1.0ml
Concentrate
E3631
7.0ml
Ready-to-Use
Clone: SP126
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Testis, Tonsil
anti-NFκB p50 antibody E363
anti-iNOS antibody M426
Product Narrative: NF kappa B is a heterodimer consisting of a DNA binding subunit and
a transactivating subunit (RelA). P50 subunit of NFkB has an isoform and two proteins
of 105 and 100kDa respectively. The p50/p65 heterodimer is present in the cytoplasm in
active form bound to its inhibitor, IkB. Upon stimulation of cells with stimuli like LPS, IL-1,
IkB gets phosphorylated and degraded by proteosomes releasing the activated NFkB
which goes to the nucleus inducing gene expression.
Product Narrative: Inducible NOS (iNOS) or macrophage NOS (mNOS) is calcium/
calmodulin independent and is expressed in activated macrophages and stimulated glial
cells. NOS oxidizes a guanidine nitrogen of arginine, releasing nitric oxide in the form of
a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse
functions including vasodilation, neurotransmission, anti-tumor and anti-pathogenic
activities.
NFkB p65 Rabbit Polyclonal
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3740
0.1ml
Concentrate
Concentrate
domain of human NFκB p65.
E3742
0.5ml
Concentrate
C-terminus of mouse i-NOS.
Application: IHC-P
E3744
1.0ml
Concentrate
Application: IHC-P
E3741
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2750
0.1ml
Concentrate
E2752
0.5ml
E2754
1.0ml
Concentrate
E2751
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Prostate
anti-NFκB/p65 antibody E275
anti-iNOS antibody E374
Product Narrative: NF kappa B is a heterodimer consisting of a 50kDa DNA binding
subunit and a 65kDa transactivating subunit (RelA). The p50/p65 heterodimer is present
in the cytoplasm in inactive form bound to its inhibitor, IκB. In unstimulated cells,
nuclear localization signals present on p65 are masked by members of the IκB family
of inhibitory proteins. Subsequent to cell stimulation, IκB undergoes phosphorylation,
ubiquitination and degradation by a proteosome-dependent pathway.
Product Narrative: NOS oxidizes a guanidine nitrogen of arginine releasing nitric
oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a
messenger in diverse functions including vasodilation neurotransmission, anti-tumor
and anti-pathogenic activities. Inducible NOS (iNOS) or macrophage NOS (mNOS) is
calcium/calmodulin independent and is expressed in activated macrophages and
stimulated glial cells. This antibody reacts with iNOS.
Nitric Oxide Synthase-Endothelial (eNOS) Rabbit Polyclonal
Nitric Oxide Synthase-Universal (uNOS) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3930
0.1ml
Concentrate
Concentrate
C-terminus of human e-NOS.
E3932
0.5ml
Concentrate
C-terminus of mouse iNOS and nNOS.
Application: IHC-P
E3934
1.0ml
Concentrate
Application: IHC-P
E3931
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4110
0.1ml
Concentrate
E4112
0.5ml
E4114
1.0ml
Concentrate
E4111
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-e-NOS antibody E411
anti-uNOS antibody E393
oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a
and anti-pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS)
or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial
NOS (eNOS). This antibody reacts with eNOS.
oxide in the form of a free radical and citrulline. Nitric oxide thus generated, acts as a
and anti-pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS)
or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial
NOS (eNOS). This antibody reacts with iNOS, bNOS and eNOS.
85
NKX3.1 Rabbit Polyclonal
NRF2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12500
0.1ml
Concentrate
Concentrate
N-terminus of human NKX3.1
E12502
0.5ml
Concentrate
C-terminus of human NRF2 protein.
Application: IHC-P
E12504
1.0ml
Concentrate
Application: IHC-P
E12501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14100
0.1ml
Concentrate
E14102
0.5ml
E14104
1.0ml
Concentrate
E14101
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate, Prostate Carcinoma
Control Tissue: Placenta, Lung
anti-NKX3.1 antibody E1410
anti-Nrf2 antibody E1250
Product Narrative: The NKX3.1 gene is an androgen regulated prostate-specific
homeobox gene, located on chromosome 8p21. In mice, the homologue NKX3.1 is
exclusively expressed in prostate epithelium. In humans, NKX3.1 expression is also
restricted to the prostate. Many data show that NKX3.1 expression is highly, but not
exclusively, specific for the prostate.
Product Narrative: NRF1 (also designated TCF11), NRF2 and NRF3 are bZIP transcription
factors that heterodimerize with Maf proteins to bind MARE (Maf recognition elements)
sequences. NRF2 is widely expressed and is thought to translocate to the nucleus after
treatment with xenobiotics and antioxidants, which stimulate its release from a repressor
protein Keap1.
Notch-1 Rabbit Polyclonal
Occludin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17460
0.1ml
Concentrate
Concentrate
human notch-1.
E17462
0.5ml
Concentrate
Application: IHC-P
E17464
1.0ml
Concentrate
E17461
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E10860
0.1ml
Concentrate
E10862
0.5ml
E10864
1.0ml
Concentrate
E10861
7.0ml
Ready-to-Use
Clone: N/A
occludin.
Isotype: Rabbit IgG
Control Tissue: Breast Carcinoma, Ovarian Carcinoma
Isotype: Rabbit IgG
anti-occludin antibody E1746
anti-notch-1 antibody E1086
Product Narrative: The 280-330kDa Notch proteins have been found to be
overexpressed or rearranged in human tumors. Ligands for notch include Jagged,
Jagged-2 and delta. Jagged can activate notch and prevent myoblast differentiation by
inhibiting the expression of muscle regulatory and structural genes.
Product Narrative: Occludin can exist in a variety of phosphorylated forms, ranging up
to approximately 82kDa. This phosphorylation is thought to be involved in regulating
both the localization and the function of occludin. Polyunsaturated fatty acids are
known to up-regulate occludin expression. The level of occludin varies. In brain tissue,
occludin is highly expressed at cell-cell contact sites, whereas non-neural tissues show
lower expression and discontinuous distribution.
N-Ras (Q61R) Rabbit Monoclonal
OCT-1 Rabbit Polyclonal
Catalog No.
Size
Format
M4740
0.1ml
Concentrate
M4742
0.5ml
Concentrate
M4744
1.0ml
Concentrate
M4741
7.0ml
Ready-to-Use
Clone: N/A
Clone: SP174
Catalog No.
Size
Format
N-Ras protein containing N-Ras (Q61R) point
mutation.
E3840
0.1ml
Concentrate
E3842
0.5ml
Concentrate
C-terminus of human OCT-1.
E3844
1.0ml
Concentrate
Application: IHC-P
E3841
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: SK-MEL-2 Cell Line
Control Lysate: SK-MEL-2 Cell Lysate
SK-MEL-2 cells stained with
anti-N-Ras (Q61R) antibody M474
Product Narrative: GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein.
Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then
stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAPmediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma
and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation,
resistance to both apoptosis and cancer therapy.
86
anti-Oct-1 antibody E384
Product Narrative: The POU dimer from the OCT-1 gene formed on the palindromic
OCT factor recognition element, or PORE (ATTTGAAATGCAAAT), could recruit the
transcriptional coactivator OBF1. OCT-1 encodes one protein, NF-A1, which is found
in nuclear extracts from all cell types and thus is not specific to lymphoid cells as is
the protein NF-A2, which is encoded by OCT-2. The OCT-1 and OCT-2 map to human
chromosomes 1q22-q23 and 19, respectively.
Primary Antibodies
OCT-2 Rabbit Polyclonal
Osteopontin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3280
0.1ml
Concentrate
Concentrate
C-terminus of human OCT-2.
E3282
0.5ml
Concentrate
domain of human osteopontin.
Application: IHC-P
E3284
1.0ml
Concentrate
Application: IHC-P
E3281
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4300
0.1ml
Concentrate
E4302
0.5ml
E4304
1.0ml
Concentrate
E4301
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-Oct-2 antibody E430
anti-osteopontin antibody E328
Product Narrative: OCT-2 is a transcription factor belonging to the POU homeo-domain
family that binds to the Ig gene octomer sites regulating B cell specific genes. OCT-2
protein expression is not restricted to B cells, although expression levels are much
higher in these cells. OCT-2 expression is reported to be significantly greater in germinal
center derived lymphomas, although other B cell lymphomas also display high levels of
expression.
Product Narrative: Osteopontin is a 34kDa extracellular matrix protein with a cell
binding domain. It was originally identified as a major component of the noncollagenous organic bone matrix, however, it has subsequently been demonstrated in a
wide range of normal adult tissue and body fluids. It is involved in bone mineralization,
cell adhesion, cell migration, chronic inflammatory disease and transformation.
OCT-3/OCT-4 Rabbit Polyclonal
p14ARF Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4350
0.1ml
Concentrate
Concentrate
internal region of human OCT-3/OCT-4 protein.
E4352
0.5ml
Concentrate
C-terminus of human p14ARF.
Application: IHC-P
E4354
1.0ml
Concentrate
Application: IHC-P
E4351
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17720
0.1ml
Concentrate
E17722
0.5ml
E17724
1.0ml
Concentrate
E17721
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Seminoma
Control Tissue: Lymphoma
Human seminoma stained with
anti-Oct-3/Oct-4 antibody E1772
Human lymphoma stained with
anti-p14ARF antibody E435
Product Narrative: OCT-3 (also known as OCT-4) is a mammalian POU transcription
factor expressed by early embryo cells and germ cells. OCT-3/4 is essential for the
identity of the pluripotential founder cell population in the mammalian embryo. A
critical amount of OCT-3/4 is required to sustain stem cell renewal, and up or down
regulation induce divergent developmental programs.
Product Narrative: The INK4a-ARF locus encodes two unrelated proteins both of
which function in tumor suppression. p14ARF binds to mdm2 and promotes the rapid
degradation of mdm2 protein required for mdm2 modification and concurrent p53
stabilization and accumulation. This interaction is mediated by the exon 1beta-encoded
N-terminal domain of p14ARF and a C-terminus region of mdm2.
OCT-3/OCT-4 Rabbit Polyclonal
p27Kip1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2600
0.1ml
Concentrate
Concentrate
internal region of human OCT-3/OCT-4 protein.
E2602
0.5ml
Concentrate
C-terminus of human p27Kip1.
Application: IHC-P
E2604
1.0ml
Concentrate
Application: IHC-P
E2601
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18280
0.1ml
Concentrate
E18282
0.5ml
E18284
1.0ml
Concentrate
E18281
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Seminoma
Control Tissue: Colon, Prostate
anti-Oct-3/Oct-4 antibody E1828
anti-p27Kip1 antibody E260
Product Narrative: OCT-3 (also known as OCT-4) is a mammalian POU transcription
factor expressed by early embryo cells and germ cells. OCT-3/4 is essential for the
identity of the pluripotential founder cell population in the mammalian embryo. A
critical amount of OCT-3/4 is required to sustain stem cell renewal, and up or down
regulation induce divergent developmental programs.
Product Narrative: This antibody recognizes a protein of 27kDa, identified as p27Kip1.
p27Kip1 is a candidate tumor suppressor gene and functions as a negative regulator
of G1 progression and has been proposed to function as a possible mediator of TGF-b
induced G1 arrest.
87
p300/CBP Rabbit Polyclonal
p53 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E16570
0.1ml
Concentrate
Immunogen: Recombinant human p53 protein.
Concentrate
C-terminus of human p300.
E16572
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E16574
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16571
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E14070
0.1ml
Concentrate
E14072
0.5ml
E14074
E14071
Clone: SPM514
Isotype: Mouse IgG2a/k
Isotype: Rabbit IgG
anti-p300 antibody E1407
Product Narrative: The p300-CBP is composed of two transcriptional co-activating
proteins with similar structures: p300 and CBP. Both p300 and CBP interact with
numerous transcription factors and act to increase the expression of their target genes
such as cAMP-regulated enhancer (CRE). Both contain five protein interaction domains:
the nuclear receptor interaction domain, the CREB-MYB interaction domain, the
cysteine/histidine regions and the interferon binding domain.
Product Narrative: p53 is a tumor suppressor gene expressed in a wide variety of tissue
types and is involved in regulating cell growth, replication, and apoptosis. It binds to
mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage
and possibly facilitates repair. Mutation involving p53 is found in a wide variety of
malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
p53 Rabbit Monoclonal
p53 Rabbit Polyclonal
Clone: SP5
Catalog No.
Size
Format
E2010
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant human full length wild type
p53 protein.
E2012
0.5ml
Concentrate
p53 protein.
Application: IHC-P
E2014
1.0ml
Concentrate
Application: IHC-P
E2011
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3050
0.1ml
Concentrate
M3052
0.5ml
M3054
1.0ml
Concentrate
M3051
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-p53 antibody M305
p53 Rabbit Monoclonal
p57** Rabbit Monoclonal
Clone: SP161
Catalog No.
Size
Format
M4180
0.1ml
Concentrate
Concentrate
p53 protein.
M4182
0.5ml
Concentrate
Immunogen: Synthetic peptide corresponding to an
internal region of human p57 protein.
Application: IHC-P
M4184
1.0ml
Concentrate
Application: IHC-P
M4181
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4610
0.1ml
Concentrate
M4612
0.5ml
M4614
1.0ml
Concentrate
M4611
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
88
Clone: SP118
Product Narrative: Cyclin-dependent kinase inhibitor 1C (CDKN 1C or p57/Kip2) is a
nuclear protein and a potent inhibitor for several G1 cyclin/Cdk complexes. P57 inhibits
cell proliferation and the mutation of p57 gene can lead to uncontrollable cell growth
and malignancy such as hydatidiform mole.
Primary Antibodies
p57 Rabbit Polyclonal
p70S6k (Phospho T421/S424) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18500
0.1ml
Concentrate
Concentrate
N-terminus of human p57/kip2 protein.
E18502
0.5ml
Concentrate
Application: IHC-P
E18504
1.0ml
Concentrate
E18501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18990
0.1ml
Concentrate
E18992
0.5ml
E18994
1.0ml
Concentrate
E18991
7.0ml
Ready-to-Use
Clone: N/A
region of human p70S6K that contains phosphorylated
threonine 421 and serine 424.
Application: IHC-P
Isotype: Rabbit IgG
Control Tissue: Hydatid Mole, Placenta
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain, Breast Carcinoma
Human hydatid mole (stromal area) stained with
anti-p70S6K (phospho T421/S424) antibody E1850
Product Narrative: p57/Kip 2 (or CDKN 1C) is a potent tight binding inhibitor of several
G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding
human p57/Kip 2 is located on chromosome 11p15.5, a region implicated in both
sporadic cancers, Wilm’s tumor, and Beckwith Wiedemann syndrome (BWS, a cancer
syndrome) making p57/Kip 2 a tumor suppressor candidate.
Product Narrative: Ribosomal S6 kinase has two isoforms, termed S6K1 (S6Ka) and S6K2
(S6Kb). The S6K1 isoform has two splicing forms: p70S6K or p70S6K1 with a molecular
mass of 70kDa and the second isoform, p85S6K or p85S6K1 with a molecular mass
of 85kDa. Both p70 and p85 S6K1 are activated by multiple S/T phosphorylations in
response to various mitogenic stimuli and nutrients. This antibody detects p70S6K only
when phosphorylated at T421/S424.
p70S6k Rabbit Polyclonal
p120 (catenin delta 1) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3630
0.1ml
Concentrate
Concentrate
region of human p70S6k protein.
M3632
0.5ml
Concentrate
human p120.
Application: IHC-P
M3634
1.0ml
Concentrate
Application: IHC-P
M3631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18640
0.1ml
Concentrate
E18642
0.5ml
E18644
1.0ml
Concentrate
E18641
7.0ml
Ready-to-Use
Clone: SP63
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-p70S6k antibody E1864
of 85kDa. Both, p70 and p85 S6K1 are activated by multiple S/T phosphorylations in
response to various mitogenic stimuli and nutrients.
Product Narrative: Catenin delta 1 (p120) is an efficient tyrosine kinase substrate
implicated both in cell transformation by SRC and in ligand-induced receptor signaling
through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to
cadherins produces a complex which is linked to the actin filament network, and which
seems to be of primary importance for the cell-adhesion properties of cadherins.
p70S6k (Paired 421/424) Rabbit Polyclonal
p120 (catenin delta 1) Rabbit Polyclonal
Catalog No.
Size
Format
E18510
0.1ml
Concentrate
E18512
0.5ml
Concentrate
E18514
1.0ml
Concentrate
E18511
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
of human p70S6K that contains non-phosphorylated
threonine 421 and serine 424.
E17530
0.1ml
Concentrate
Clone: N/A
E17532
0.5ml
Concentrate
C-terminus of human p120.
E17534
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E17531
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-p70S6K (paired421/424) antibody E1851
of 85kDa. Both p70 and p85 S6K1 are activated by multiple S/T phosphorylations in
response to various mitogenic stimuli and nutrients. This antibody detects p70S6K that is
non-phosphorylated at T421/S424.
Human breast lobular carcinoma stained with
Product Narrative: Catenin delta 1 (p120) is an efficient tyrosine kinase substrate
implicated both in cell transformation by SRC and in ligand-induced receptor signaling
through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to
cadherins produces a complex which is linked to the actin filament network, and which
seems to be of primary importance for the cell-adhesion properties of cadherins.
89
PAK alpha Rabbit Polyclonal
Parathyroid Hormone Receptor 1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17890
0.1ml
Concentrate
Concentrate
aa 525-545 of rat PAK alpha.
E17892
0.5ml
Concentrate
Application: IHC-P
E17894
1.0ml
Concentrate
E17891
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12550
0.1ml
Concentrate
E12552
0.5ml
E12554
1.0ml
Concentrate
E12551
7.0ml
Ready-to-Use
Clone: N/A
N-terminus of human parathyroid hormone receptor
type 1.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Parathyroid Gland
anti-PAK alpha antibody E1255
Human parathyroid gland stained with
anti-PTH receptor type 1 antibody E1789
Product Narrative: Alpha PAK p68, beta PAK p65 and gamma PAK p62 are three isoforms
of serine/threonine kinases. These three isoforms complex specifically with Rac1 and
Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to
their autophosphorylation.
Product Narrative: Two human parathyroid hormone (hPTH) receptors are known: one
that binds both hPTH and a PTH-related protein called PTHrP (the Type I receptor); and
one that only binds hPTH (the Type II receptor).
Parathyroid Hormone (PTH) Rabbit Polyclonal
Parkin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3470
0.1ml
Concentrate
Concentrate
C-terminus of human parathyroid hormone.
E3472
0.5ml
Concentrate
N-terminus of human parkin protein.
Application: IHC-P
E3474
1.0ml
Concentrate
Application: IHC-P
E3471
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18090
0.1ml
Concentrate
E18092
0.5ml
E18094
1.0ml
Concentrate
E18091
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Parathyroid Gland
Human parathyroid gland stained with
anti-parathyroid hormone antibody E1809
anti-parkin antibody E347
Product Narrative: Parathyroid hormone (PTH) is secreted by parathyroid cells. This
hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their
renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism.
Most PTH is secreted in its intact, mature 9.5kDa form, amino acids 1-84; however, it
can also be secreted as N-terminal truncated fragments or C-terminus fragments after
intracellular degradation, as in case of hypercalcemia.
Product Narrative: Parkin has been mapped to chromosome 6 and encodes a protein
of 465 amino acids with similarity to ubiquitin at the amino terminus and a RINGfinger motif at the carboxyl terminus. Parkinson’s disease is the second most common
neurodegenerative disease following Alzheimer’s. The characteristic movement disorder
results from dysfunction and neuron loss in the substantia nigra. Deletions in Parkin
have been associated with autosomal-recessive juvenile parkinsonism.
Parathyroid Hormone (PTH) Rabbit Monoclonal
PAX-5 Rabbit Monoclonal
Clone: SP151
Catalog No.
Size
Format
M3340
0.1ml
Concentrate
Concentrate
internal region of human PTH protein.
M3342
0.5ml
Concentrate
C-terminus of human PAX-5 protein.
Application: IHC-P
M3344
1.0ml
Concentrate
Application: IHC-P
M3341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4510
0.1ml
Concentrate
M4512
0.5ml
M4514
1.0ml
Concentrate
M4511
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Parathyroid Glands
Human parathyroid stained with
anti-PTH antibody M451
anti-Pax-5 antibody M334
Product Narrative: Parathyroid hormone (PTH) is secreted by parathyroid cells. PTH
increases blood Ca2+ levels by dissolving the salts in bone and preventing their renal
excretion. Most PTH is secreted in its intact, mature 9.5 kDa form, amino acids 1-84;
however, it can also be secreted as N-terminal truncated fragments or C-terminal
fragments after intracellular degradation, as in the case of hypercalcemia.
90
Clone: SP34
Product Narrative: PAX-5 is a B cell specific activator protein. In the early stages of B cell
development, PAX-5 influences the expression of several B cell specific genes, such as
CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not
in plasma cells. PAX-5 mRNA is transiently detected in the mesencephalon and spinal
cord during embryogenesis and then shifts to the fetal liver. This indicates that PAX-5 is
important in B cell and neuronal development.
Primary Antibodies
PAX-5 Rabbit Polyclonal
PCNA Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2850
0.1ml
Concentrate
Concentrate
C-terminus of human PAX-5 protein.
E2852
0.5ml
Concentrate
PCNA protein.
Application: IHC-P
E2854
1.0ml
Concentrate
E2851
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4390
0.1ml
Concentrate
E4392
0.5ml
E4394
1.0ml
Concentrate
E4391
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Small Intestine, Tonsil
anti-pax-5 antibody E439
anti-PCNA antibody E285
Product Narrative: PAX-5 is a B cell specific activator protein. In the early stages of B cell
development, PAX-5 influences the expression of several B cell specific genes, such as
CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not
in plasma cells. PAX-5 mRNA is transiently detected in the mesencephalon and spinal
cord during embryogenesis and then shifts to the fetal liver. This indicates that PAX-5 is
important in B cell and neuronal development.
Product Narrative: Expression of proliferating cell nuclear antigen (PCNA) or cyclin
or polymerase delta auxiliary protein is elevated in the nucleus during late G1 phase
immediately before the onset of DNA synthesis, becoming maximal during S-phase and
declining during G2 and M phases. PCNA/cyclin may act as an auxiliary protein of DNA
polymerase-delta to play a fundamental role in the initiation of cell proliferation.
Paxillin Rabbit Polyclonal
PD-1/CD279 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E18660
0.1ml
Concentrate
Concentrate
aa 356-558 of human paxillin.
E18662
0.5ml
Concentrate
Application: IHC-P
E18664
1.0ml
Concentrate
Application: IHC-P
E18661
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13870
0.1ml
Concentrate
E13872
0.5ml
E13874
1.0ml
Concentrate
E13871
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-paxillin antibody E1387
anti-PD-1/CD279 antibody E1866
Product Narrative: Paxillin is a focal adhesion protein and a substrate for several tyrosine
kinases such as SRC, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin
is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with
FAK and CRK through its SH2 domain. Although paxillin was initially discovered in
fibroblasts, its phosphorylation may also be important during neurite extension during
differentiation.
Product Narrative: CD279, also known as Programmed Cell Death 1 (PD-1), is an
immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8
thymocytes, and on activated T and B cells. It is thought to be involved in lymphocyte
clonal selection and peripheral tolerance. The PD-1 ligands, PDL1 (also known as B7H1)
and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
PCNA Rabbit Monoclonal
PD-1/CD279 Rabbit Polyclonal
Clone: N/A
Clone: SP136
Catalog No.
Size
Format
E18630
0.1ml
Concentrate
Concentrate
Immunogen: Full length recombinant
human PCNA protein.
E18632
0.5ml
Concentrate
region of human PD-1/CD279 protein.
Application: IHC-P
E18634
1.0ml
Concentrate
Application: IHC-P
E18631
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4360
0.1ml
Concentrate
M4362
0.5ml
M4364
1.0ml
Concentrate
M4361
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lymph Node, Tonsil
anti-PCNA antibody M436
anti-PD-1/CD279 antibody E1863
Product Narrative: Expression of proliferating cell nuclear antigen (PCNA) is elevated
in the nucleus during late G1 phase immediately before the onset of DNA synthesis,
becoming maximal during S-phase and declining during G2 and M phases. PCNA may
act as an auxiliary protein of DNA polymerase-delta to play a fundamental role in the
initiation of cell proliferation.
Product Narrative: CD279, also known as Programmed Cell Death 1 (PD-1), is an
immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8
thymocytes, and on activated T and B cells. It is thought to be involved in lymphocyte
clonal selection and peripheral tolerance. The PD-1 ligands, PDL1 (also known as B7H1)
and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
91
PDCD6 Rabbit Polyclonal
PDK-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18410
0.1ml
Concentrate
Concentrate
C-terminus of human PDCD6 protein.
E18412
0.5ml
Concentrate
human PDK-1.
Application: IHC-P
E18414
1.0ml
Concentrate
Application: IHC-P
E18411
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17690
0.1ml
Concentrate
E17692
0.5ml
E17694
1.0ml
Concentrate
E17691
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PDCD6 antibody E1769t
anti-PDK1 antibody E1841
Product Narrative: This gene encodes a calcium-binding protein belonging to the
penta-EF-hand protein family. Calcium binding is important for homodimerization and
for conformational changes required for binding to other protein partners. This gene
product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed
cell death. In mice deficient for this gene product, however, apoptosis was not blocked
suggesting this gene product is functionally redundant.
Product Narrative: Phosphoinositide-dependent protein kinase 1 (PDK1) plays a
central role in many signal transduction pathways, including the activation of Akt and
PKC isoenzyme p70S6 kinase and RSK. Through its effects on these kinases, PDK1 is
involved in the regulation of a wide variety of processes, including cell proliferation,
differentiation and apoptosis.
PDGFR alpha Rabbit Polyclonal
PDS-1/Securin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18530
0.1ml
Concentrate
Concentrate
C-terminus of human PDGFR alpha.
E18532
0.5ml
Concentrate
region of human PDS-1 protein.
Application: IHC-P
E18534
1.0ml
Concentrate
Application: IHC-P
E18531
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2690
0.1ml
Concentrate
E2692
0.5ml
E2694
1.0ml
Concentrate
E2691
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Kidney, Ovarian Carcinoma, Skin
anti-PDGFR-alpha antibody E269
anti-PDS-1 / securin antibody E1853
Product Narrative: PDGFR (Platelet Derived Growth Factor Receptor) exhibits two
different isoforms, alpha and beta, coded by two different genes. PDGF alpha receptors
are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are
expressed on neurons. This antibody is specific for PDGFR alpha and does not react with
PDGFR beta.
Product Narrative: Securin is an anaphase inhibitor and plays an important role in
DNA damage and spindle check point pathways. It is targeted for degradation by
ubiquitination mediated by a ubiquitin ligase - anaphase promoting complex (APC).
Securin is highly expressed in various human tumors, including pituitary, adrenal,
kidney, liver, and ovarian tumors, and in cell lines derived from pituitary tumors, breast
tumors, endometrial tumors, and ovarian tumors.
PDGFR beta Rabbit Polyclonal
Peripheral Myelin Protein (PMP-22) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3520
0.1ml
Concentrate
Concentrate
C-terminus of human PDGFR beta.
E3522
0.5ml
Concentrate
Immunogen: Synthetic peptide from near C-terminus of
human PMP-22.
Application: IHC-P
E3524
1.0ml
Concentrate
Application: IHC-P
E3521
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2730
0.1ml
Concentrate
E2732
0.5ml
E2734
1.0ml
Concentrate
E2731
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Kidney, Ovarian Carcinoma, Skin
anti-PDGFR-beta antibody E273
anti-PMP22 antibody E352
Product Narrative: PDGFR (Platelet Derived Growth Factor Receptor) exhibits two
different isoforms, alpha and beta, coded by two different genes. PDGF alpha receptors
are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are
expressed on neurons. This antibody is specific for PDGFR beta and does not react with
PDGFR alpha.
92
Clone: N/A
Product Narrative: PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in
the compact myolin of the peripheral nervous system. In the peripheral nervous system,
PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for
myelin basic protein (MBP) and protein P0 during nerve development and regeneration.
Alterations in the level of this protein cause several genetic human diseases.
Primary Antibodies
Phospho-Ser/Thr/Tyr Mouse Monoclonal
PI3K p85 Rabbit Monoclonal
Clone: SPM101
Catalog No.
Size
Format
M3620
0.1ml
Concentrate
Concentrate
Immunogen: Phosphoserine, phosphothreonine, and
phosphotyrosine conjugated to protein carriers.
M3622
0.5ml
Concentrate
human PI3K p85.
1.0ml
Concentrate
Application: WB
M3624
1.0ml
Concentrate
Application: IHC-P
N/A
N/A
M3621
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3070
0.1ml
Concentrate
E3072
0.5ml
E3074
N/A
Clone: SP62
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: N/A
Molecular Weight: 20 KDa
N/A E307
anti-PI3K p85 antibody M362
Product Narrative: This antibody recognizes serine, threonine, and tyrosine
phosphorylated proteins as determined by ELISA using phosphorylated peptides.
Reactivity has also been shown with phosphorylated proteins in western blots.
Product Narrative: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of
phosphatidylinositol at the 3-prime position. The enzyme comprises a 110kDa catalytic
subunit and a regulatory subunit of either 85, 55, or 50kDa. This antibody is specific to
PI3K p85 which is a 85kDa regulatory subunit.
Phosphotyrosine Mouse Monoclonal
PI3K p85 Rabbit Polyclonal
Clone: SPM102
Catalog No.
Size
Format
E18200
0.1ml
Concentrate
Concentrate
Immunogen: Phosphotyrosine conjugated to
protein carriers.
E18202
0.5ml
Concentrate
N-terminus of human PI3K p85.
Application: IHC-P
E18204
1.0ml
Concentrate
Application: IHC-P
E18201
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3080
0.1ml
Concentrate
E3082
0.5ml
E3084
1.0ml
Concentrate
E3081
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Mouse IgG1
Isotype: Rabbit IgG
anti-phosphotyrosine antibody E308
anti-PI3K p85 antibody E1820
Product Narrative: Protein phosphorylation is a fundamental event in the regulation of
a large number of intracellular processes. This antibody is specific to phosphotyrosine
and shows no cross-reaction with other phosphoamino acids.
phosphatidylinositol at the 3-prime position. The enzyme comprises a 110kDa catalytic
subunit and a regulatory subunit of either 85, 55, or 50kDa. This antibody is specific to
PI3K p85 which is a 85kDa regulatory subunit.
PI3K p110beta Rabbit Polyclonal
pI3KCA Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4390
0.1ml
Concentrate
Concentrate
internal region of human PI3k p110beta.
M4392
0.5ml
Concentrate
the human pI3KCA protein.
Application: IHC-P
M4394
1.0ml
Concentrate
Application: IHC-P
M4391
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18210
0.1ml
Concentrate
E18212
0.5ml
E18214
1.0ml
Concentrate
E18211
7.0ml
Ready-to-Use
Clone: SP139
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PI3k p110beta antibody E1821
anti-pI3KCA antibody M439
phosphatidylinositol. The enzyme comprises a 110kDa catalytic subunit and a regulatory
subunit of either 85, 55, or 50kDa. The loss of p110 beta decreases tumorigenesis in a
mouse cancer model with lipid phosphatase PTEN deficiency. This antibody is specific to
PI3K p110beta.
Product Narrative: Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit
alpha isoform (PI3KCA) catalyzes the production of phosphatidylinositol-3, 4,
5-triphosphate (PIP3). PIP3 activates downstream signaling components such as protein
kinase AKT and promotes cell growth and survival. PI3KCA mutations are associated
with colorectal cancer, breast cancer, ovarian cancer, endometrial carcinoma and
hepatocellular carcinoma.
93
PIM-1 Rabbit Polyclonal
PLAP Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3150
0.1ml
Concentrate
Concentrate
region of human PIM-1 protein.
M3152
0.5ml
Concentrate
placental alkaline phosphatase.
Application: IHC-P
M3154
1.0ml
Concentrate
Application: IHC-P
M3151
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18710
0.1ml
Concentrate
E18712
0.5ml
E18714
1.0ml
Concentrate
E18711
7.0ml
Ready-to-Use
Clone: SP15
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Adenocarcinoma
Control Tissue: Placenta, Seminoma
anti-PIM-1 antibody E1871
anti-PLAP antibody M315
Product Narrative: PIM-1 is a member of the serine/threonine kinase PIM oncogene
family. PIM-1 has been implicated in lymphomagenesis, cell proliferation, apoptosis,
differentiation and tumourigenesis. The PIM-1 protein kinase is upregulated in
prostate cancer.
Product Narrative: This antibody reacts with a membrane-bound isoenzyme of
placental alkaline phosphatase (PLAP) occurring in the placenta during the 3rd trimester
of gestation. It is expressed in testicular germ cell tumors. Unlike germ cell tumors, PLAPpositive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
PIM-2 Rabbit Polyclonal
PLAP Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E2040
0.1ml
Concentrate
Concentrate
C-terminus of human PIM-2 protein.
E2042
0.5ml
Concentrate
placental alkaline phosphatase.
Application: IHC-P
E2044
1.0ml
Concentrate
Application: IHC-P
E2041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18800
0.1ml
Concentrate
E18802
0.5ml
E18804
1.0ml
Concentrate
E18801
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: B Cell Lymphoma
Control Tissue: Placenta, Seminoma
anti-PIM-2 antibody E1880
anti-PLAP antibody E204
Product Narrative: PIM-2 belongs to a family of cytoplasmic serine/threonine protein
kinases that consists of two other members, PIM-1 and PIM-3. Expression of this
protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed
in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as
in testis, small intestine, and colon. PIM-2 is thought to be a mediator of p53 mediated
apoptosis inhibition by interleukin 3.
Product Narrative: This antibody reacts with a membrane-bound isoenzyme of
placental alkaline phosphatase (PLAP) occurring in the placenta during the 3rd trimester
of gestation. It is expressed in testicular germ cell tumors. Unlike germ cell tumors, PLAPpositive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
Placental Lactogen (hPL) Rabbit Polyclonal
PLC beta 1 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E14110
0.1ml
Concentrate
Concentrate
Immunogen: Purified human placental
lactogen.
E14112
0.5ml
Concentrate
C-terminus of human PLC beta 1.
E14114
1.0ml
Concentrate
Application: IHC-P
E14111
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2980
0.1ml
Concentrate
E2982
0.5ml
E2984
1.0ml
Concentrate
E2981
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-hPL antibody E298
Product Narrative: Human placental lactogen (hPL) is known to originate in the
syncytiotrophoblasts. Ultrastructural localization indicates that placental lactogen
is stored in small morphologically distinct cytoplasmic granules within these cells
and has a different secretory mechanism from other hormonal peptides such as
human chorionic gonadotropin. The level of expression of placental lactogen through
pregnancy increases gradually to term.
94
anti-PLC beta 1 antibody E1411
Product Narrative: Phosphoinositide-specific phospholipase C (PLC) plays a crucial
role in the initiation of receptor mediated signal transduction through the generation
of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes such
as PLC β1a and PLC β1b. PLC β1a is preferentially expressed in the cytosol, whereas PLC
β1b is predominantly localized in the nuclei.
Primary Antibodies
PLC gamma 2 Rabbit Polyclonal
PMS2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18560
0.1ml
Concentrate
Concentrate
C-terminus of human PLC gamma 2 protein.
E18562
0.5ml
Concentrate
C-terminus of human PMS2 protein.
Application: IHC-P
E18564
1.0ml
Concentrate
Application: IHC-P
E18561
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12470
0.1ml
Concentrate
E12472
0.5ml
E12474
1.0ml
Concentrate
E12471
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PLC gamma 2 antibody E1247
anti-PMS2 antibody E1856
Product Narrative: Phosphoinositide-specific phospholipase C (PLC) plays a critical
role in the initiation of receptor mediated signal transduction through the generation
of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from
phosphatidylinositol 4,5 bisphosphate. There are many mammalian PLC isozymes,
including PLC B1, PLC B2, PLC B3, PLCB4, PLCy1, PLCy2, PLC 81, PLC82 and PLCe with
molecular weights ranging from 85 to 150kDa.
Product Narrative: Mismatch DNA repair in bacteria is carried out by the MutL, MutH,
and MutS proteins. The MutS protein initially binds to mismatched DNA. This is followed
by binding of the MutH endonuclease and MutL to form a complex that carries out
excision repair. The hMSH2 gene specifies a MutS homologue whereas hMLH1, hPMS1,
and hPMS2 encode MutL homologs. Mutations in these genes are associated with
hereditary nonpolyposis colon cancer (HNPCC).
Pleiotrophin Rabbit Polyclonal
Poly ADP-Ribose Polymerase (PARP) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4220
0.1ml
Concentrate
Concentrate
N-terminus of human pleiotrophin protein.
E4222
0.5ml
Concentrate
N-terminus of human PARP protein.
Application: IHC-P
E4224
1.0ml
Concentrate
Application: IHC-P
E4221
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18820
0.1ml
Concentrate
E18822
0.5ml
E18824
1.0ml
Concentrate
E18821
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Brain, Colon Carcinoma
Human cerebellum stained with
anti-pleiotrophin antibody E1882
anti-PARP antibody E422
Product Narrative: Pleiotrophin (PTN) is a secreted heparin and chondroitin-binding
protein. It is a regulatory cytokine critical to the early development of blood vessels and
neurons. High PTN serum levels are associated with a variety of solid tumors such as
multiple myeloma (MM). The amount of PTN is correlated with the MM disease status and
response to treatment. The expression of this protein is very limited in normal adult tissues.
Product Narrative: PARP uses nicotinamide adenine dinucleotide (oxidized form) NAD
as a substrate to catalyze the transfer of ADP-ribose to a variety of nuclear protein
acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of
programmed cell death and is mediated by the caspase CPP32 protein.
PML Rabbit Polyclonal
Presenilin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3480
0.1ml
Concentrate
Concentrate
N-terminus of human PML.
E3482
0.5ml
Concentrate
N-terminus of human presenilin 1 protein.
Application: IHC-P
E3484
1.0ml
Concentrate
Application: IHC-P
E3481
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12400
0.1ml
Concentrate
E12402
0.5ml
E12404
1.0ml
Concentrate
E12401
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lymph Node
anti-PML antibody E1240
anti-presenilin 1 antibody E348
Product Narrative: The PML protein is a zinc finger transcription factor expressed
as three major transcription products due to alternative splicing. The t(15;17)
(q22;q11.2-q12) chromosomal translocation of the retinoic acid receptor alpha gene
occurs in virtually all cases of acute promyelocytic leukemia. Myeloid precursor cells
expression the PML/RAR alpha chimera fail to differentiate and exhibit an increased
growth rate consequent to diminished apoptosis. growth rate consequent to diminished
apoptosis.
Product Narrative: In addition to β-amyloid precursor protein (β-APP), three other gene
products have been implicated in Familial Alzheimer’s Disease (FAD): presenilin 1 (PS-1),
presenilin 2 (PS-2), and apolipoprotein E (apoE4). Mutations in the genes encoding
β-APP, PS-1, and PS-2 are believed to contribute to presenile FAD.
95
Progesterone Receptor (PR) Rabbit Monoclonal
Prohibitin Rabbit Polyclonal
Clone: SP2
Catalog No.
Size
Format
E17750
0.1ml
Concentrate
Concentrate
aa 412-526 of human progesterone receptor.
E17752
0.5ml
Concentrate
C-terminus of human prohibitin protein.
Application: IHC-P
E17754
1.0ml
Concentrate
Application: IHC-P
E17751
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3020
0.1ml
Concentrate
M3022
0.5ml
M3024
1.0ml
Concentrate
M3021
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PR antibody M302
anti-prohibitin antibody E1775
Product Narrative: The progesterone receptor (PR) is an estrogen-regulated protein. It
has been proposed that expression of PR determination indicates a responsive estrogen
receptor (ER) pathway. A number of studies have shown that PR determination provides
supplementary information to ER.
Product Narrative: Prohibitin is an evolutionarily conserved protein located in the
inner membrane of mitochondria. Prohibitin appears to be a very reliable marker of
mitochondria. Prohibitin shows antiproliferative activity and has been proposed to play
a role in normal cell cycle regulation, replicative senescence, cellular immortalization,
and tumor suppression.
Progesterone Receptor (PR) Rabbit Polyclonal
Prolactin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17490
0.1ml
Concentrate
Immunogen: Purified human prolactin.
Concentrate
C-terminus of human PgR.
E17492
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E17494
1.0ml
Concentrate
7.0ml
Ready-to-Use
E17491
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2070
0.1ml
Concentrate
E2072
0.5ml
E2074
E2071
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PR antibody E207
anti-prolactin antibody E1749
Product Narrative: Prolactin is a pituitary hormone involved in the stimulation of milk
production, salt and water regulation, growth, development and reproduction. Prolactin
producing cells make up approximately 20% of the pituitary.
Progesterone Receptor (PR) Rabbit Monoclonal
Prostate Apoptosis Response 4 (PAR-4) Rabbit Polyclonal
Clone: SP42
Catalog No.
Size
Format
E3420
0.1ml
Concentrate
Concentrate
aa 412-526 of human progesterone receptor.
E3422
0.5ml
Concentrate
Application: IHC-P
E3424
1.0ml
Concentrate
E3421
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3420
0.1ml
Concentrate
M3422
0.5ml
M3424
1.0ml
Concentrate
M3421
7.0ml
Ready-to-Use
Clone: N/A
C-terminus of human prostate apoptosis response
4 protein.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PR antibody M342
96
anti-PAR-4 antibody E342
Product Narrative: Prostate apoptosis response-4 (PAR-4) is a 38kDa protein originally
identified as the product of a gene that is upregulated in prostate tumor cells
undergoing apoptosis. It is a leucine zipper and death domain-containing protein whose
levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal
or exposure to oxidative and metabolic insults. PAR-4 levels are increased in the spinal
cord specimens from patients with neuronal degeneration.
Primary Antibodies
Prostate Specific Antigen (PSA) Rabbit Polyclonal
PSMA Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human PSA.
M3290
0.1ml
Concentrate
Concentrate
Application: IHC-P
M3292
0.5ml
Concentrate
C-terminus of human PSMA.
M3294
1.0ml
Concentrate
Application: IHC-P
M3291
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2960
0.1ml
E2962
0.5ml
E2964
1.0ml
Concentrate
E2961
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: SP29
Isotype: Rabbit IgG
anti-PSA antibody E296
anti-PSMA antibody M329
Product Narrative: PSA is a chymotrypsin-like serine protease (kallikrein family)
exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA
can be detected in the sera of patients with prostatic carcinoma. It is predominantly
complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT).
A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign
prostate hyperplasia.
Product Narrative: Prostate-specific membrane antigen (PSMA) is a type II
transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally
distinct proteins are encoded including folylpoly-gamma-glutamate carboxypeptidase
in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and
prostate-specific membrane antigen in the prostate. PSMA is involved in prostate tumor
progression.
Prostate Stem Cell Antigen (PSCA) Rabbit Polyclonal
PSMA Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17330
0.1ml
Concentrate
Concentrate
extracellular region of human PSCA protein.
E17332
0.5ml
Concentrate
C-terminus of human PSMA.
Application: IHC-P
E17334
1.0ml
Concentrate
Application: IHC-P
E17331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3290
0.1ml
Concentrate
E3292
0.5ml
E3294
1.0ml
Concentrate
E3291
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-PSCA antibody E329
anti-PSMA antibody E1733
Product Narrative: PSCA (Prostate Stem Cell antigen) is a cell surface antigen, which
is overexpressed in approximately 40% of primary prostate cancers and in as many as
100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and
pancreatic carcinomas.
Product Narrative: Prostate-specific membrane antigen (PSMA) is a type II
transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally
distinct proteins are encoded including folylpoly-gamma-glutamate carboxypeptidase
in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and
prostate-specific membrane antigen in the prostate. PSMA is involved in prostate tumor
progression.
Protein Gene Protein 9.5 (PGP9.5) Rabbit Polyclonal
RACK-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E18910
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant full length
human protein gene product 9.5 protein.
E18912
0.5ml
Concentrate
region of human RACK-1 protein.
E18914
1.0ml
Concentrate
Application: IHC-P
E18911
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3340
0.1ml
Concentrate
E3342
0.5ml
E3344
1.0ml
Concentrate
E3341
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas, Small Intestine
anti-PGP9.5 antibody E334
Product Narrative: Protein gene product (PGP9.5) is a neuron specific protein distinct
from neuron specific enolase. PGP9.5 is present in neurons, nerve fibers, neuroendocrine
cells, renal tubules, spermatogonia, Leydig cells of the testis, ova and some cells of both
the pregnant and non-pregnant corpus luteum.
anti-RACK-1 antibody E1891
Product Narrative: RACK-1 (receptor for activated C kinase 1) was identified through
its binding to various PKC isoforms. Its main function is to recruit PKC and various other
proteins to specific locations to form multiprotein complexes, mediating various signal
pathways.
97
RAD51 Rabbit Polyclonal
RCC1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E13440
0.1ml
Concentrate
Concentrate
N-terminus of human RAD51 protein.
E13442
0.5ml
Concentrate
N-terminus of human RCC1.
Application: IHC-P
E13444
1.0ml
Concentrate
Application: IHC-P
E13441
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19100
0.1ml
Concentrate
E19102
0.5ml
E19104
1.0ml
Concentrate
E19101
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-RAD51 antibody E1910
anti-RCC-1 antibody E1344
Product Narrative: RAD51 is a member of the RAD51 protein family involved in repair
of DNA double strand breaks. The protein is highly conserved in most eukaryotes from
yeast to humans. It can interact with the ssDNA-binding protein RPA and Rad52, and is
thought to play roles in homologous pairing and strand transfer of DNA. The interactions
between Rad51 with BRCA1 and BRCA2 may be important for the cellular response to
DNA damage. RAD51 is overexpressed in a variety of tumors.
Product Narrative: Regulator of Chromosome Condensation 1 (RCC-1) binds to
chromatin and participates in the regulation of chromosome condensation in the S
phase. RCC-1 interacts with GTP-binding nuclear protein Ran and catalyzes guanine
nucleotide exchange. Both RCC-1 and Ran are components of an intrinsic checkpoint
control that prevents the premature initiation of mitosis.
RAN Rabbit Polyclonal
Retinoblastoma (Rb) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4310
0.1ml
Concentrate
Concentrate
aa 197-216 of human RAN protein.
E4312
0.5ml
Concentrate
C-terminus of human retinoblastoma.
Application: IHC-P
E4314
1.0ml
Concentrate
Application: IHC-P
E4311
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12460
0.1ml
Concentrate
E12462
0.5ml
E12464
1.0ml
Concentrate
E12461
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-Ran antibody E1246
anti-RB antibody E431
Product Narrative: The small Ras-related protein Ran, also called TC4, is a 24kDa,
nuclear localized GTPase implicated in a diverse array of cellular processes including
DNA replication, entry into and exit from mitosis and the transport of RNA and proteins
through the nuclear pore complex.
Product Narrative: Rb is a tumor suppressor nuclear phosphoprotein capable of binding
to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues.
It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma
virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to
uncontrolled cell growth.
RCAS1 Rabbit Polyclonal
Retinoic Acid Receptor beta Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4370
0.1ml
Concentrate
Concentrate
C-terminus of human RCAS1.
E4372
0.5ml
Concentrate
N-terminus of human RAR beta.
Application: IHC-P
E4374
1.0ml
Concentrate
Application: IHC-P
E4371
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16370
0.1ml
Concentrate
E16372
0.5ml
E16374
1.0ml
Concentrate
E16371
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Heart, Testis
anti-RCAS-1 antibody E1637
HHuman testis stained with
anti-hRARbeta antibody E437
Product Narrative: RCAS-1 (Receptor binding cancer antigen expressed on SiSo cells)
is a type III transmembrane protein mostly in the Golgi. It induces apoptosis of natural
killer (NK)/T cells through activation of interleukin-1-beta converting enzyme (ICE)-like
proteases. RCAS-1 is abundantly expressed in prostate cancer cells when compared to
normal epithelial cells.
98
Clone: N/A
Product Narrative: Retinoids are metabolites of vitamin A and represent important
signaling molecules during vertebrate development and tissue differentiation. Two
families of retinoid receptors have been identified: retinoic acid receptors (RARs-α, -β
and -γ); and retinoid X receptors (RXR-α, -β and -γ). RXRs have a high affinity for all-trans
retinoic acids and belong to the same class of nuclear transcription factors such as
thyroid hormone receptors and vitamin D3 receptor.
Primary Antibodies
Retinoic X Receptor gamma Rabbit Polyclonal
RRM1 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M4670
0.1ml
Concentrate
Concentrate
from N-terminus of mouse RXR gamma.
M4672
0.5ml
Concentrate
human RRM1 protein.
M4674
1.0ml
Concentrate
Application: IHC-P
M4671
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4330
0.1ml
Concentrate
E4332
0.5ml
E4334
1.0ml
Concentrate
E4331
7.0ml
Ready-to-Use
Clone: SP167
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Prostate Carcinoma
Control Tissue: Lung Adenocarcinoma
Control Lysate: NIH3T3
anti-RXR-gamma antibody E433
Human lung adenocarcinoma stained with
anti-RRM1 antibody M467
Product Narrative: Retinoids are metabolites of vitamin A and represent important
signaling molecules during vertebrate development and tissue differentiation. Two
families of retinoid receptors have been identified: retinoic acid receptors (RAR-α, RAR-β
and RAR-γ); and retinoid X receptors (RXR-α, RXR-β and RXR-γ). RXRs are activated by
9-cis-retinoic acid, a stereo- and photoisomer of all-trans-RA expressed in vivo in both
liver and kidney.
Product Narrative: Ribonucleotide reductase M1 polypeptide (RRM1) is one of two
non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which
catalyzes the biosynthesis of deoxyribonucleotides. It provides the precursors necessary
for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated
in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the
response of non-small-cell lung cancer (NSCLC) to chemotherapy.
RHO Rabbit Polyclonal
RRM1 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E18040
0.1ml
Concentrate
Concentrate
corresponding to human Rho protein.
E18042
0.5ml
Concentrate
human RRM1.
1.0ml
Concentrate
Application: WB
E18044
1.0ml
Concentrate
Application: IHC-P
N/A
N/A
E18041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17850
0.1ml
Concentrate
E17852
0.5ml
E17854
N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: N/A
anti-RRM1 antibody E1804
N/A E1785
Product Narrative: The RHO proteins are members of the Ras superfamily of small
GTP-binding proteins. The RHO proteins play an important role in the organization of
actin cytoskeleton, cell adhesion, cell motility and smooth muscle contraction. The RHO
proteins are also involved in the signal transduction pathways mediated by the actin
cytoskeleton and the activation of the stress activated MAP kinase cascades.
Product Narrative: RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two nonidentical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme
which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding
ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is
involved in carcinogenesis and tumor progression.
ROC1 Rabbit Polyclonal
S100 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E2140
0.1ml
Concentrate
Concentrate
C-terminus of human ROC1.
E2142
0.5ml
Concentrate
S100 protein.
Application: IHC-P
E2144
1.0ml
Concentrate
Application: IHC-P
E2141
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4190
0.1ml
Concentrate
E4192
0.5ml
E4194
1.0ml
Concentrate
E4191
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Melanoma, Schwannoma
anti-ROC1 antibody E419
anti-S100 antibody E214
Product Narrative: ROC1 and ROC2 are the two highly conserved RING finger proteins
that are homologous to APC11, a subunit of the anaphase-promoting complex (APC).
ROC1 and ROC2 commonly interact with all cullins. ROC1 and APC11 immunocomplexes
can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2dependent manner. ROC1 is thought to play a unique role in the ubiquitination reaction
by heterodimerizing with cullin1 to catalyze ubiquitin polymerization.
Product Narrative: S100 belongs to the family of calcium binding proteins such as
calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas
S100B is composed of two beta chains. The antibody to S100 stains schwannomas,
ependymomas, astrogliomas, almost all benign and malignant melanomas and their
metastases. S100 protein is also expressed in the antigen presenting cells such as the
Langerhans cells in skin and interdigitating reticulum cells.
99
S100 beta Rabbit Monoclonal
S6 Ribosomal (Paired 235/236) Rabbit Polyclonal
Clone: SP127
Catalog No.
Size
Format
E18080
0.1ml
Concentrate
Concentrate
S100 beta.
E18082
0.5ml
Concentrate
Application: IHC-P
E18084
1.0ml
Concentrate
E18081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4270
0.1ml
Concentrate
M4272
0.5ml
M4274
1.0ml
Concentrate
M4271
7.0ml
Ready-to-Use
Clone: N/A
from the region of human S6 ribosomal that
contains unphosphorylated serines 235
and 236.
Isotype: Rabbit IgG
Control Tissue: Colon, Melanoma
Isotype: Rabbit IgG
anti-S100 beta antibody M427
anti-S6 ribosomal antibody E1808
S100B is composed of two beta chains. S100 is highly expressed in melanocyte, nerve
cells, and their tumors. S100 protein is also expressed in the antigen presenting cells
such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex
of lymph nodes.
Product Narrative: 40S ribosomal protein S6 (RPS6) is a substrate of p70 S6 kinase
(p70S6K) and a major component of translational machinery involved in protein
synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation
on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. This antibody detects non-phosphorylated S6 ribosomal at 235/236
serine residue..
S100A4 Rabbit Polyclonal
S6 Ribosomal (Paired 240/244) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17770
0.1ml
Concentrate
Concentrate
encoding full length human S100A4.
E17772
0.5ml
Concentrate
E17774
1.0ml
Concentrate
E17771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4440
0.1ml
Concentrate
E4442
0.5ml
E4444
1.0ml
Concentrate
E4441
7.0ml
Ready-to-Use
Clone: N/A
region of human S6 ribosomal that contains
non-phosphorylated serines 240 and 244.
Application: IHC-P
Isotype: Rabbit IgG
Control Tissue: Melanoma, Tonsil
Isotype: Rabbit IgG
anti-S100A4 antibody E444
anti-S6 ribosomal (paired 240/244) antibody E1777
S100B is composed of two beta chains. S100 protein is also expressed in the antigen
presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in
the paracortex of lymph node.
on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. Hyperphosphorylation of RPS6 stimulates protein synthesis. This antibody detects
non-phosphorylated S6 ribosomal at 240/244 serine residue.
S6 Ribosomal Rabbit Polyclonal
S6 Ribosomal (Phospho S235/236) Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3500
0.1ml
Concentrate
Concentrate
from internal region of human S6 ribosomal.
M3502
0.5ml
Concentrate
M3504
1.0ml
Concentrate
M3501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17780
0.1ml
Concentrate
E17782
0.5ml
E17784
1.0ml
Concentrate
E17781
7.0ml
Ready-to-Use
Clone: SP50
of human S6 ribosomal that contains phosphorylated
serines 235 and 236.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-S6 ribosomal antibody E1778
Product Narrative: 40S ribosomal protein S6 (also known as RPS6) is a 31kDa substrate
of p70 S6 kinase (p70S6K) and a major component of translational machinery involved
in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes
phosphorylation on multiple serines in the carboxyl terminal region in the order 236->235-->240-->244-->247. Hyperphosphorylation of RPS6 stimulates protein synthesis
that mediates progression through the cell cycle.
100
anti-S6 (phospho S235/236) antibody M350
S6 ribosomal only when it is phosphorylated at 235/236 serine residue.
Primary Antibodies
S6 Ribosomal (Phospho S235/236) Rabbit Polyclonal
Catalog No.
Size
Format
E18070
0.1ml
Concentrate
E18072
0.5ml
Concentrate
E18074
1.0ml
Concentrate
E18071
7.0ml
Ready-to-Use
SHIP-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E14060
0.1ml
Concentrate
Clone: N/A
E14062
0.5ml
Concentrate
C-terminus of human SHIP-1.
E14064
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E14061
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-S6 ribosomal E1807
anti-SHIP-1 antibody E1406
S6 ribosomal only when it is phosphorylated at 235/236 serine residue.
Product Narrative: SHIP-1 p145 (SH2-containing-inositol phosphatase) contains
two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain,
and two highly conserved motifs found among inositol phosphate 5-phosphatases.
SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5
-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that
SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.
S6 Ribosomal (Phospho S240/244) Rabbit Monoclonal
SH-PTP2 Rabbit Polyclonal
Catalog No.
Size
Format
M3450
0.1ml
Concentrate
M3452
0.5ml
Concentrate
M3454
1.0ml
Concentrate
M3451
7.0ml
Ready-to-Use
Clone: SP45
Catalog No.
Size
Format
E12440
0.1ml
Concentrate
E12442
0.5ml
Concentrate
aa 576-593 of human SH-PTP2 protein.
E12444
1.0ml
Concentrate
Application: IHC-P
Application: IHC-P
E12441
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow
anti-S6 (phsopho S240/244) M345
anti-SH-PTP2 antibody E1244
Product Narrative: 40S ribosomal protein S6 (RPS6) is a 31kDa substrate of p70 S6
kinase (p70S6K) and a major component of translational machinery involved in protein
on multiple serines in the carboxyl terminal region in the order 236-->235-->240-->244->247. This antibody detects S6 ribosomal only when it is phosphorylated at 240/244
serine residue.
Product : The steady state of protein tyrosyl phosphorylation in cells is regulated by the
opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). SH-PTP1
is primarily expressed in hematopoietic cells and characterized by the presence of two
SH2 domains N-terminal to the PTP domain. SH-PTP2 works on the downstream of
various receptor and cytoplasmic protein tyrosine kinases to participate in the signal
transduction from the cell surface to the nucleus.
S6 Ribosomal (Phospho S240/244) Rabbit Polyclonal
SKP1 p19 Rabbit Polyclonal
Catalog No.
Size
Format
E17760
0.1ml
Concentrate
E17762
0.5ml
Concentrate
E17764
1.0ml
Concentrate
E17761
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
E14120
0.1ml
Concentrate
E14122
0.5ml
Concentrate
E14124
1.0ml
Concentrate
Application: IHC-P
E14121
7.0ml
Ready-to-Use
Clone: N/A
SKP1 p19.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-S6 ribosomal (phospho S240/244) antibody E1776
S6 Ribosomal only when it is phosphorylated at 240/244 serine residue.
anti-SKP1 p19 antibody E1412
Product Narrative: SKP1 p19 and SKP2 p45 are two cyclin A-CDK2 complex binding
proteins participating in cell cycle regulation. Cyclin A accumulates prior to cyclin B
in the cell cycle, appears to be involved in control of S phase and has been shown to
associate with cyclin dependent kinase-2 (CDK2). Although the Skps (S phase kinaseassociated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit
any regulatory effects on the complex.
101
SKP2 p45 Rabbit Polyclonal
SMA Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E19220
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein encoding aa
221-425 of human SKP2 alpha.
E19222
0.5ml
Concentrate
human smooth muscle actin-alpha.
Application: IHC-P
E19224
1.0ml
Concentrate
Application: IHC-P
E19221
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13880
0.1ml
Concentrate
E13882
0.5ml
E13884
1.0ml
Concentrate
E13881
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Small Intestine
anti-SKP2 p45 antibody E1388
anti-SMA antibody E1922
Product Narrative: SKP2 (S-phase Kinase-associated Protein 2) belongs to the family
of F-box proteins that interact with the cyclin A-CDK2 complex. SKP2 is essential for
the G1-S transition in both transformed cells and diploid fibroblasts. SKP2 is widely
expressed in normal and cancer tissues such as tonsil, placenta and cancers from colon,
prostate, pancreas, skin, lung, breast, ovarian, and endometrium. SKP2 plays a role in
oncogenesis, particularly in lymphomas and breast cancers.
Product Narrative: Smooth muscle actin-alpha is a cytoskeleton protein in smooth
muscle cells and their derived tumors such as leiomyoma and leiomyosarcoma. It is also
expressed in myoepithelial cells of the breast and salivary gland, but not in fibroblasts,
striated muscle, and myocardium.
SLIT2 Rabbit Monoclonal
SMAD3 Rabbit Polyclonal
Clone: SP122
Catalog No.
Size
Format
E11250
0.1ml
Concentrate
Concentrate
C-terminus of human SLIT2 protein.
E11252
0.5ml
Concentrate
internal region of human SMAD3.
Application: IHC-P
E11254
1.0ml
Concentrate
Application: IHC-P
E11251
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4220
0.1ml
Concentrate
M4222
0.5ml
M4224
1.0ml
Concentrate
M4221
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Breast, Breast Carcinoma
anti-SLIT2 antibody M422
anti-SMAD3 antibody E1125
Product Narrative: SLIT2 are ligands for Robo receptors and play a vital role for axonal
migration/navigation during neural development. A number of cleavage products
through alternate splicing are reported in the literature for SLIT2 proteins. The C-terminal
cleavage proteins are more diffusible than the larger N-terminal protein that is more
tightly cell associated. SLIT2 protein is expressed in tissues such as fetal lung, kidney, and
adult spinal cord.
Product Narrative: SMAD proteins mediate signaling events leading to transcriptional
activation initiated by members of the TGF-beta superfamily. Biological activities
mediated by smads include cell growth and morphogenesis, development, and
immune response. A reduction in SMAD2/3 signaling enhances tumorigenesis, but also
suppresses metastasis of breast cancer cell lines.
SLIT2 Rabbit Polyclonal
SMRTe Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10990
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near N-terminus of
human SLIT2.
E10992
0.5ml
Concentrate
aa 994-1005 of human SMRTe protein.
Application: IHC-P
E10994
1.0ml
Concentrate
Application: IHC-P
E10991
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19050
0.1ml
Concentrate
E19052
0.5ml
E19054
1.0ml
Concentrate
E19051
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Fetal Kidney, Prostate Carcinoma
Control Tissue: Brain, Lung Carcinoma
anti-SLIT2 antibody E1905
anti-SMRTe antibody E1099
Product Narrative: Slit homolog 2 proteins (SLIT2) are ligands for the Roundabout
(Robo) receptors and act as molecule guidance cues in cell migration. Slit1 and Slit2 are
essential for midline guidance in the forebrain by acting as repulsive signals preventing
inappropriate midline crossing by axons projecting from the olfactory bulb. Slit2
protein is expressed in fetal lung and kidney, and adult spinal cord. SLIT2 is a target for
repression by EZH2 and is up-regulated in prostate cancer.
102
Clone: N/A
Product Narrative: SMRT is 1495 amino acids and contains an 8 amino acid sequence
that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe
contains an N-terminal sequence spanning over 1,000 amino acids that is not present
in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated
during cell cycle progression, suggesting a role for SMRTe in the regulation of cyclespecific gene expression in diverse signaling pathways.
Primary Antibodies
SOCS-2 Rabbit Polyclonal
Sodium Channel-pan Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10290
0.1ml
Concentrate
Concentrate
C-terminus of human SOCS-2 protein.
E10292
0.5ml
Concentrate
Application: IHC-P
E10294
1.0ml
Concentrate
E10291
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16720
0.1ml
Concentrate
E16722
0.5ml
E16724
1.0ml
Concentrate
E16721
7.0ml
Ready-to-Use
Clone: N/A
of the alpha subunit of rat type 1 voltage-gated
sodium channel.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-SOCS-2 antibody E1672
anti-sodium channel pan antibody E1029
Product Narrative: Suppressor of Cytokine Signaling (SOCS) includes eight members
of SOCS family (SOCS-1, 2, 3, 4, 5, 6, 7 and CIS). Structurally the SOCS proteins are
composed of an N-terminal region of variable length and amino acid composition, a
central SH2 domain, and a previously unrecognized C-terminus motif called the SOCS
box. The SOCS-2 appear to form part of a classical negative feed back loop that regulates
cytokine signal transduction.
Product Narrative: Voltage-gated sodium channels (VGSC) are present in most excitable
cells. In neuronal tissue, they are responsible for generating and propagating action
potentials. Brain VGSCs are heteromers of αβ1β2 subunits. Of these, the α subunit forms
the channel pore. This antibody recognizes the alpha subunit of type I voltage-gated
sodium channel.
Sonic Hedgehog Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E17920
0.1ml
Concentrate
Concentrate
E17922
0.5ml
Concentrate
N-terminus of human sonic hedgehog.
Application: IHC-P
E17924
1.0ml
Concentrate
Application: IHC-P
E17921
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16850
0.1ml
Concentrate
E16852
0.5ml
E16854
1.0ml
Concentrate
E16851
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Testis
Control Tissue: Fetal Brain, Lung
Cellular Localization: Extracellular Matrix, Membrane
anti-SOCS3 antibody E1685
anti-Sonic Hedgehog antibody E1792
Product Narrative: Suppressor of Cytokine Signaling 3 (SOCS-3) is involved in
negative regulation of cytokines that signal through the JAK/STAT pathway. It inhibits
cytokine signal transduction by binding to tyrosine kinase receptors including gp130,
LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. It suppresses fetal liver
erythropoiesis and regulates onset and maintenance of allergic responses mediated by
T-helper type 2 cells.
Product Narrative: Sonic Hedgehog (SHH) is expressed only during embryogenesis
and is instrumental in patterning in the early embryo. It has been implicated as the key
inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis,
and the ventral somites. SHH binds to the patched (PTC) receptor, which functions in
association with smoothened (SMO), to activate the transcription of target genes.
SOX-2 Rabbit Monoclonal
Clone: N/A
Catalog No.
Size
Format
M3760
0.1ml
Concentrate
Concentrate
M3762
0.5ml
Concentrate
Application: IHC-P
M3764
1.0ml
Concentrate
M3761
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16780
0.1ml
Concentrate
E16782
0.5ml
E16784
1.0ml
Concentrate
E16781
7.0ml
Ready-to-Use
Clone: SP76
corresponding to N-terminus of human
SOX-2 protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Newborn Brain
anti-SOCS-6 antibody E1678
Product Narrative: Suppressor of Cytokine Signaling 6 (SOCS-6) interacts with the
insulin receptor (IR) when expressed in human hepatoma cells (HepG2) overexpressing
human IR. SOCS-1 and SOCS-6 inhibit insulin-dependent activation of ERK1/2 and
protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. SOCS-6
proteins may be inhibitors of IR signaling and could mediate cytokine-induced insulin
resistance and contribute to the pathogenesis of type II diabetes.
Human newborn brain stained with
anti-SOX-2 antibody M376
Product Narrative: SOX-2 is also known as SRY related HMG BOX gene 2. It is a
transcription factor that forms a trimeric complex with OCT4 on DNA and controls the
expression of a number of genes involved in embryonic development such as YES1,
FGF4, UTF1 and ZFP206. It is critical for early embryogenesis and for embryonic stem cell
pluripotency. SOX-2 is highly expressed in glioma, lung cancer and stomach cancer.
103
SOX-2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E14040
0.1ml
Concentrate
Concentrate
N-terminus of human SOX-2 protein
E14042
0.5ml
Concentrate
aa 316-510 of human SOX-9 protein.
Application: IHC-P
E14044
1.0ml
Concentrate
Application: IHC-P
E14041
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18600
0.1ml
Concentrate
E18602
0.5ml
E18604
1.0ml
Concentrate
E18601
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Newborn Brain, Skin
Human newborn brain stained with
anti-SOX-2 antibody E1860
Product Narrative: SOX-2 is also known as SRY related HMG BOX gene 2. It is a
transcription factor that forms a trimeric complex with OCT4 on DNA and controls the
expression of a number of genes involved in embryonic development such as YES1,
FGF4, UTF1 and ZFP206. It is critical for early embryogenesis and for embryonic stem cell
pluripotency. SOX-2 is highly expressed in glioma, lung cancer and stomach cancer.
Product Narrative: SOX-9 is a member of the SOX family (Sry-type high mobility group
box) genes that was first identified on the basis of region with high homology to that
of SRY (Sex-determining region Y). SOX-9 is a transcription factor with a high mobility
group DNA-binding domain in all prechondrocytic and chondrocytic cells during
embryonic development. SOX-9 regulates expression of chondrocyte phenotype
related genes.
Clone: N/A
Catalog No.
Size
Format
E16820
0.1ml
Concentrate
Concentrate
internal region of human SOX-4 protein.
E16822
0.5ml
Concentrate
C-terminus of human SOX-14 protein.
Application: IHC-P
E16824
1.0ml
Concentrate
Application: IHC-P
E16821
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16380
0.1ml
Concentrate
E16382
0.5ml
E16384
1.0ml
Concentrate
E16381
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Fetal Brain
anti-sox4 antibody E1638
Human fetal brain stained with
Product Narrative: SOX-4 is a member of the SOX (SRY-related HMG-box) family of
transcription factors involved in the regulation of embryonic development and in the
determination of the cell fate. SOX-4 binds with high affinity to the T-cell enhancer
motif 5’-AACAAAG-3’ motif. Sox-4 is expressed in lymphocytes (B and T) and it is
required for B lymphocyte development. It is also expressed in breast, breast cancer,
medulloblastoma, and prostate cancer.
Product Narrative: The SOX (SRY-box containing gene) gene family encodes a group of
transcription factors defined by the conserved high motility group (HMG) DNA-binding
domain. They are involved in the regulation of embryonic development and in the
determination of cell fate (specifically neuronal). SOX-14 is most closely related to SOX
factors 1, 2 and 3 and likely mirrors expression of these genes in the developing brain
and spinal cord.
SP1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12540
0.1ml
Concentrate
Concentrate
aa 1-150 of human SOX-9 protein.
E12542
0.5ml
Concentrate
C-terminus of human SP1.
Application: IHC-P
E12544
1.0ml
Concentrate
Application: IHC-P
E12541
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E13470
0.1ml
Concentrate
E13472
0.5ml
E13474
1.0ml
Concentrate
E13471
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-SOX9 antibody E1347
anti-SP1 antibody E1254
Product Narrative: SOX-9 is a member of the SOX family (Sry-type high mobility group
box) genes that was first identified on the basis of region with high homology to that
of SRY (Sex-determining region Y). SOX-9 is a transcription factor with a high mobility
group DNA-binding domain in all prechondrocytic and chondrocytic cells during
embryonic development. SOX-9 regulates expression of chondrocyte phenotype
related genes.
Product Narrative: SP1 is a sequence-specific transcription factor that recognizes
GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes.
SP1 belongs to a subgroup of transcription factors that are phosphorylated upon
binding to promoter sequences.
104
Primary Antibodies
Spink1** Rabbit Monoclonal
STAT3 Rabbit Polyclonal
Clone: SP166
Catalog No.
Size
Format
E3690
0.1ml
Concentrate
Concentrate
Immunogen: Full length recombinant
protein of human spink1.
E3692
0.5ml
Concentrate
aa 50-240 of human Stat3.
E3694
1.0ml
Concentrate
Application: IHC-P
E3691
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4660
0.1ml
Concentrate
M4662
0.5ml
M4664
1.0ml
Concentrate
M4661
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Lysate: Human Pancreas
Molecular Weight: 8.5 kDa
anti-STAT3 antibody E369
anti-Spink1 antibody M466
Product Narrative: Spink1 is a trypsin inhibitor secreted from pancreatic acinar cells
into pancreatic juice. It prevents the trypsin-catalyzed premature activation of
zymogens within the pancreas and the pancreatic duct. Spink-1 is overexpressed in
some prostate carcinoma.
Product Narrative: The STAT3 protein is a transcription factor expressed in most cell
types and is activated by multiple cytokines and growth factors including: IFN-a,
IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. STAT3 binds to DNA as either a homodimer or as a
heterodimer with STAT1. STAT3 interacts with the APRE (acute phase response element)
and SIE (c-sis inducible element).
ST13 Rabbit Polyclonal
STAT5 alpha Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E3590
0.1ml
Concentrate
Concentrate
human ST13.
E3592
0.5ml
Concentrate
from C-terminus of human STAT5 alpha.
Application: IHC-P
E3594
1.0ml
Concentrate
E3591
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17870
0.1ml
Concentrate
E17872
0.5ml
E17874
1.0ml
Concentrate
E17871
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-STAT5α antibody E359
anti-ST13 antibody E1787
Product Narrative: ST13 is a cofactor of heat shock protein 70 (HSP70). To date, all data
since the discovery of ST13 in 1993 until more recent studies in 2007 have proved that
ST13 is down regulated in tumors and it is proposed to be a tumor suppressor gene.
Product Narrative: STAT5a protein is a transcription factor activated by hormone and
cytokines. Two highly related, but distinct STAT5 genes (STAT5a and STAT5b) were
identified in mouse. STAT5a is critically involved in a variety of physiological functions,
including reproduction, lactation, immune function and somatic growth.
Stanniocalcin-2 Rabbit Polyclonal
STAT6 Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4290
0.1ml
Concentrate
Concentrate
region of human stanniocalcin-2 protein.
E4292
0.5ml
Concentrate
C-terminus of human STAT6.
Application: IHC-P
E4294
1.0ml
Concentrate
Application: IHC-P
E4291
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18840
0.1ml
Concentrate
E18842
0.5ml
E18844
1.0ml
Concentrate
E18841
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Placenta, Tonsil
anti-stanniocalcin-2 antibody E1884
anti-STAT6 antibody E429
Product Narrative: Stanniocalcin-2 is a homodimeric glycoprotein that is expressed in a
wide variety of tissues and may have autocrine or paracrine functions. The protein may
play a role in the regulation of renal and intestinal calcium and phosphate transport
and cell metabolism. In the ovary, it has been shown to be a paracrine hormone that
regulates granulosa cell function. Expression of this gene is induced by estrogen and
altered in some breast cancers.
Product Narrative: STAT6 protein is a transcription factor activated by cytokines,
particularly interleukin-4 and IL13. STAT6 was found to be deficient in IL-4-mediated
functions including Th2 helper T-cell differentiation, expression of cell surface
markers, and T-cell proliferation. STAT6 mRNA has been detected in peripheral blood
lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and
placenta. STAT6 is critically involved in Th2 immune response.
105
Stathmin Rabbit Monoclonal
Survivin Rabbit Polyclonal
Clone: SP49
Catalog No.
Size
Format
E3770
0.1ml
Concentrate
Concentrate
from internal region of human stathmin.
E3772
0.5ml
Concentrate
C-terminus of human survivin.
E3774
1.0ml
Concentrate
Application: IHC-P
E3771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3490
0.1ml
Concentrate
M3492
0.5ml
M3494
1.0ml
Concentrate
M3491
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-survivin antibody E377
anti-stathmin antibody M349
Product Narrative: Stathmin is a ubiquitous cytosolic phosphoprotein proposed
to function as an intracellular relay integrating regulatory signals of the cellular
environment. The encoded protein is involved in the regulation of the microtubule
filament system by destabilizing microtubules. It prevents assembly and promotes
disassembly of microtubules. Alternatively spliced transcript variants encoding the same
protein have been identified.
Product Narrative: Survivin is an inhibitor of apoptosis (IAP) protein. It is expressed
in the G2/M phase of the cell cycle in a cycle-regulated manner. The overexpression
of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant
progression of transformed cells through mitosis.
Stathmin Rabbit Polyclonal
SYK Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4050
0.1ml
Concentrate
Concentrate
from internal region of human stathmin.
E4052
0.5ml
Concentrate
from internal region of human SYK protein.
E4054
1.0ml
Concentrate
E4051
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18060
0.1ml
Concentrate
E18062
0.5ml
E18064
1.0ml
Concentrate
E18061
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bone Marrow, Lymphoma
anti-stathmin antibody E1806
anti-Syk antibody E405
Product Narrative: Stathmin is a ubiquitous cytosolic phosphoprotein proposed
to function as an intracellular relay integrating regulatory signals of the cellular
environment. The encoded protein is involved in the regulation of the microtubule
filament system by destabilizing microtubules. It prevents assembly and promotes
disassembly of microtubules. Alternatively spliced transcript variants encoding the same
protein have been identified.
Product Narrative: SYK, a protein tyrosine kinase (PTK) is expressed in immature T cells,
all B cells, basophils, hepatocytes, platelets, and erythrocytes. It functions in some T cell
receptor signaling processes in addition to B cell receptor and integrin-mediated signal
transduction processes. SYM-/syk- mice exhibit defective phagocytosis by macrophages.
Survivin Rabbit Monoclonal
Synaptophysin Rabbit Monoclonal
Catalog No.
Size
Format
M3790
0.1ml
Concentrate
M3792
0.5ml
Concentrate
M3794
M3791
1.0ml
7.0ml
Concentrate
Ready-to-Use
Clone: SP11
Clone: SP79
Catalog No.
Size
Format
C-terminus of human survivin protein.
M3110
0.1ml
Concentrate
M3112
0.5ml
Concentrate
to C-terminus of human synaptophysin.
Application: IHC-P
M3114
1.0ml
Concentrate
M3111
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Neuroendocrine Tumor,
Pancreas, Pheochromcytoma
anti-survivin antibody M379
Product Narrative: Survivin is an inhibitor of apoptosis (IAP) protein. It is expressed
in the G2/M phase of the cell cycle in a cycle-regulated manner. The overexpression
of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant
progression of transformed cells through mitosis.
106
Human neuroendocrine tumor stained with
anti-synatophysin antibody M311
Product Narrative: Synaptophysin is expressed in neuroendocrine cells of human
adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas,
gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal
cells, neurons in the brain, spinal cord, and retina. It is also expressed in neuroendocrine
tumors such as neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.
Primary Antibodies
Synaptophysin Rabbit Polyclonal
Synuclein-alpha Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2680
0.1ml
Concentrate
Concentrate
synaptophysin.
E2682
0.5ml
Concentrate
C-terminus of human synuclein-alpha.
Application: IHC-P
E2684
1.0ml
Concentrate
Application: IHC-P
E2681
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E2170
0.1ml
Concentrate
E2172
0.5ml
E2174
1.0ml
Concentrate
E2171
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Pancreas
Control Tissue: Brain (Posterior Cingulated Gyrus)
Cellular Localization: Cytoplasm, Presynaptic Terminals
anti-synaptophysin antibody E217
anti-synuclein-alpha antibody E268
Product Narrative: Synaptophysin is expressed in neuroendocrine cells of human
adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas,
gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and of gastric parietal
cells, neurons in the brain, spinal cord, and retina. It is also expressed in neuroendocrine
tumors such as neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.
Product Narrative: Synucleins are small, soluble proteins expressed primarily in neural
tissue and in certain tumors. The family includes three known proteins: alpha-synuclein,
beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are
found primarily in brain tissue, where they are seen mainly in presynaptic terminals. This
antibody is specific for alpha-synuclein and is useful for the localization and detection of
alpha-synuclein.
Syntaxin 1A Rabbit Monoclonal
Synuclein-beta Rabbit Polyclonal
Clone: SP36
Catalog No.
Size
Format
E2770
0.1ml
Concentrate
Concentrate
N-terminus of human syntaxin 1A protein.
E2772
0.5ml
Concentrate
C-terminus of human synuclein-beta.
Application: IHC-P
E2774
1.0ml
Concentrate
Application: IHC-P
E2771
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3360
0.1ml
Concentrate
M3362
0.5ml
M3364
1.0ml
Concentrate
M3361
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Human cerebral cortex stained with
anti-syntaxin 1A antibody M336
anti-synuclein-beta antibody E277
Product Narrative: Syntaxin 1A (STX1A) is potentially involved in docking of synaptic
vesicles at presynaptic active zones and may play a critical role in neurotransmitter
exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and
musculoskeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare
developmental disorder. It is a contiguous gene deletion syndrome involving genes
from chromosome band 7q11.23.
beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are
found primarily in brain tissue, where they are seen mainly in presynaptic terminals.
This antibody is specific for beta-synuclein and does not cross react with alpha-and
gamma-synuclein.
Syntaxin 1A Rabbit Polyclonal
Synuclein-pan Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E2790
0.1ml
Concentrate
Concentrate
N-terminus of human syntaxin 1A protein.
E2792
0.5ml
Concentrate
N-terminus of human α, β, γ-Synuclein protein.
Application: IHC-P
E2794
1.0ml
Concentrate
Application: IHC-P
E2791
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17700
0.1ml
Concentrate
E17702
0.5ml
E17704
1.0ml
Concentrate
E17701
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-syntaxin 1A antibody E1770
anti-synuclein-pan antibody E279
Product Narrative: Syntaxin 1A (STX1A) is potentially involved in docking of synaptic
vesicles at presynaptic active zones and may play a critical role in neurotransmitter
exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and
musculoskeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare
developmental disorder. It is a contiguous gene deletion syndrome involving genes
from chromosome band 7q11.23.
beta-synuclein, and gamma-synuclein. The alpha- and beta- synuclein proteins are
found primarily in brain tissue. This antibody detects all synuclein proteins.
107
Tau (Neuronal Marker) Rabbit Monoclonal
Terminal Deoxynucleotidyl Transferase (TdT)** Rabbit Monoclonal
Clone: SP70
Catalog No.
Size
Format
M4500
0.1ml
Concentrate
Concentrate
N-terminus of human tau protein.
M4502
0.5ml
Concentrate
Application: IHC-P
M4504
1.0ml
Concentrate
M4501
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3700
0.1ml
Concentrate
M3702
0.5ml
M3704
1.0ml
Concentrate
M3701
7.0ml
Ready-to-Use
Clone: SP150
derived from the internal region of
human TdT protein.
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Thymus
Human breast adenocarcinoma stained with
anti-tau antibody M370
anti-TdT antibody M450
Product Narrative: Tau is a neuronal microtubule associated protein found mainly on
axons. Its function is to promote tubulin polymerization and stabilize microtubules and
to link certain signaling pathways to the cytoskeleton. Tau is the major component of
paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer’s disease (AD)
brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting
in the destruction of microtubules and neurons in AD brain.
Product Narrative: Terminal deoxynucleotidyl transferase (TdT), is a nuclear DNA
polymerase responsible for the template-independent addition of N-nucleotides. It
is expressed in normal hematopoietic cells, normal cortical thymocytes (immature,
pre-B, pre-T lymphoid cells), and megakaryocytes of the bone marrow, as well as acute
lymphoblastic leukemia/lymphoma cells.
Tau (Neuronal Marker) Rabbit Polyclonal
Thioredoxin Reductase 2 (TrxR2) Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3610
0.1ml
Concentrate
Concentrate
N-terminus of human tau protein.
E3612
0.5ml
Concentrate
C-terminus of human TrxR2.
Application: IHC-P
E3614
1.0ml
Concentrate
Application: IHC-P
E3611
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18290
0.1ml
Concentrate
E18292
0.5ml
E18294
1.0ml
Concentrate
E18291
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain, Breast Carcinoma
anti-tau antibody E1829
anti-TrxR2 antibody E361
Product Narrative: Tau is a neuronal microtubule associated protein found mainly on
axons. Its function is to promote tubulin polymerization and stabilize microtubules and
to link certain signaling pathways to the cytoskeleton. Tau is the major component of
paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer’s disease (AD)
brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting
in the destruction of microtubules and neurons in AD brain.
Product Narrative: The reduced form of thioredoxin serves as a hydrogen donor,
contributes to the up-regulation of various transcription factors and binds to and
inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by
Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in
mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial
protein. TrxR expression is induced in several tumors.
TdT Rabbit Polyclonal
Thrombin R/ATAP2 Rabbit Polyclonal
Catalog No.
Size
Format
E19230
0.1ml
Concentrate
E19232
0.5ml
Concentrate
E19234
E19231
1.0ml
7.0ml
Concentrate
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
human TdT protein.
E12530
0.1ml
Concentrate
E12532
0.5ml
Concentrate
Application: IHC-P
E12534
1.0ml
Concentrate
E12531
7.0ml
Ready-to-Use
Clone: N/A
corresponding to near N-terminus of human
thrombin R.
Isotype: Rabbit IgG
Control Tissue: Thymus, Thymomas
Isotype: Rabbit IgG
anti-TdT antibody E1923
anti-thrombin R antibody E1253
Product Narrative: Terminal deoxynucleotidyl transferase (TdT) is a nuclear DNA
polymerase responsible for the template-independent addition of N-nucleotides. It
is expressed in normal hematopoietic cells, normal cortical thymocytes (immature,
pre-B, pre-T lymphoid cells), and megakaryocytes of the bone marrow as well as acute
lymphoblastic leukemia/lymphoma cells.
Product Narrative: Thrombin is a serine protease that is involved in platelet aggregation
and blood coagulation. It is cleaved from its precursor, prothrombin, and converts
fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its
regulatory effects by activating cell surface G-protein coupled receptors which include
PAR-1, PAR-2 and PAR3.
108
Primary Antibodies
Thymidylate Synthase (TS) Rabbit Monoclonal
Thyroglobulin Mouse Monoclonal
Clone: SP112
Catalog No.
Size
Format
E16600
0.1ml
Concentrate
Immunogen: Human thyroglobulin.
Concentrate
Immunogen: Synthetic peptide near C-terminus of
human TS.
E16602
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E16604
1.0ml
Concentrate
7.0ml
Ready-to-Use
E16601
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M4120
0.1ml
Concentrate
M4122
0.5ml
M4124
M4121
Clone: SPM517
Isotype: Mouse IgG1
Isotype: Rabbit IgG
Control Tissue: Thyroid
Control Tissue: Colon Carcinoma, Tonsil
anti-TS antibody M412
anti-thyroglobulin antibody E1660
Product Narrative: Thymidylate Synthase (TS) converts deoxyuridine monophosphate
(dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA
biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Overexpression
of TS has been demonstrated in many types of tumors including breast, colon, gastric
and melanoma.
Product Narrative: Thyroglobulin is expressed in thyroid carcinomas of the papillary and
follicular types. Adenocarcinomas of non-thyroid origin are not reactive.
Thymidylate Synthase (TS) Rabbit Polyclonal
Thyroid Hormone Receptor alpha1/alpha2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4060
0.1ml
Concentrate
Concentrate
human TS.
E4062
0.5ml
Concentrate
Application: IHC-P
E4064
E4061
1.0ml
7.0ml
Concentrate
Ready-to-Use
Catalog No.
Size
Format
E17910
0.1ml
Concentrate
E17912
0.5ml
E17914
1.0ml
Concentrate
E17911
7.0ml
Ready-to-Use
Clone: N/A
N-terminus of human TR-alpha 1 protein.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-TS antibody E1791
anti-THR alpha1/2 antibody E406
(dUMP) to deoxythymidine monophosphate (dTMP) during DNA biosynthesis. TS is a
critical target for the fluoropyrimidines, an important group of antineoplastic drugs in
the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor
cells to FdUMP which inactivates TS. Over expression of TS has been demonstrated in
many types of tumors including breast, colon, gastric and melanoma.
Product Narrative: Thyroid hormone receptors (TRs) are ligand dependent members of
the steroid/retinoic acid superfamily of transcription factors. The two genes encoding
TRs identified to date, TRalpha and TRbeta, have been mapped to human chromosomes
17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with
half site binding motifs in the orientation of palindromes, direct repeats, or inverted
palindromes.
Thymidylate Synthase (TS) Rabbit Polyclonal
Thyroid Hormone Receptor beta Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4070
0.1ml
Concentrate
Concentrate
C-terminus of human TS protein.
E4072
0.5ml
Concentrate
N-terminus of human TR-beta protein.
Application: IHC-P
E4074
1.0ml
Concentrate
Application: IHC-P
E4071
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18570
0.1ml
Concentrate
E18572
0.5ml
E18574
1.0ml
Concentrate
E18571
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-TS antibody E1857
anti-THR beta antibody E407
(dUMP) to deoxythymidine monophosphate (dTMP) during DNA biosynthesis. TS is a
critical target for the fluoropyrimidines, an important group of antineoplastic drugs in
the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor
cells to FdUMP which inactivates TS. Over expression of TS has been demonstrated in
many types of tumors including breast, colon, gastric and melanoma.
Product Narrative: Thyroid hormone receptors (TRs) are ligand dependent members of
the steroid/retinoic acid superfamily of transcription factors. The two genes encoding
TRs identified to date, TRalpha and TRbeta, have been mapped to human chromosomes
17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with
half site binding motifs in the orientation of palindromes, direct repeats, or inverted
palindromes.
109
Thyroid Stimulating Hormone (TSH) Rabbit Polyclonal
TIMP-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
Concentrate
Immunogen: Purified human TSH.
E3360
0.1ml
Concentrate
Concentrate
Application: IHC-P
E3362
0.5ml
Concentrate
Immunogen: Synthetic peptide from N-terminus half of
human TIMP-1.
E3364
1.0ml
Concentrate
Application: IHC-P
E3361
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17500
0.1ml
E17502
0.5ml
E17504
1.0ml
Concentrate
E17501
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Clone: N/A
Isotype: Rabbit IgG
Control Tissue: Bladder, Breast, Colon Carcinoma,
Ovarian Carcinoma
anti-TSH antibody E1750
anti-TIMP-1 antibody E336
Product Narrative: TSH is a pituitary hormone of 28kDa, which stimulates thyroid
growth and production of thyroid hormones. This antibody labels thyrotropic cells of the
pituitary.
Product Narrative: Tissue inhibitor of metalloproteinases-1 and 2 (TIMP-1 and TIMP-2)
have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase
family, and are thought to be of great importance in the maintenance of connective
tissue integrity. TIMP-1 forms a complex with activated interstitial collagenases,
stromelysin, and type IV collagenase. TIMPs inhibit the proteolytic invasiveness of tumor
cells and normal placental trophoblast cells.
Thyroid Transcription Factor-1 (TTF-1)** Rabbit Monoclonal
Clone: SP141
Catalog No.
Size
Format
E4180
0.1ml
Concentrate
Concentrate
internal region of human TTF-1 protein.
E4182
0.5ml
Concentrate
Application: IHC-P
E4184
E4181
1.0ml
7.0ml
Concentrate
Ready-to-Use
Catalog No.
Size
Format
M4410
0.1ml
Concentrate
M4412
0.5ml
M4414
1.0ml
Concentrate
M4411
7.0ml
Ready-to-Use
Clone: N/A
N-terminus half of human TIMP-2.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Thyroid
anti-TTF-1 antibody M441
Product Narrative: Thyroid transcription factor-1 (TTF-1), also known as NK2 homeobox
1(NKX2-1), is a member of the NKx2 family of homeodomain transcription factors.
TTF-1 is expressed in epithelial cells of the thyroid gland and the lung, and their derived
tumors such as lung adenocarcinoma and small cell carcinomas and thyroid cancer. It is
absent in mesotheliomas, breast cancer, and colon cancer.
Product Narrative: Tissue inhibitor of metalloproteinases-1 and 2 (TIMP-1 and TIMP-2)
have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase
family, and are thought to be of great importance in the maintenance of connective
tissue integrity. TIMP-1 forms a complex with activated interstitial collagenases,
stromelysin, and type IV collagenase. TIMPs inhibit the proteolytic invasiveness of tumor
cells and normal placental trophoblast cells.
TIE-1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3850
0.1ml
Concentrate
Concentrate
C-terminus of human TIE-1.
E3852
0.5ml
Concentrate
C-terminus of human TIMP-3.
Application: IHC-P
E3854
1.0ml
Concentrate
Application: IHC-P
E3851
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E17520
0.1ml
Concentrate
E17522
0.5ml
E17524
1.0ml
Concentrate
E17521
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-TIE-1 antibody E1752
Product Narrative: TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and
TIE2/Tek are expressed primarily on endothelial and hematopoietic progenitor cells, and
play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing
vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind
TIE have been identified, angiopoietin 1 and angiopoietin 2. The in vivo functions of TIE1
are related to endothelial cell differentiation.
110
Clone: N/A
Product Narrative: TIMPs (Tissue Inhibitors of Metallo Proteinases) form tight inhibitory
complexes with MMPs which are involved in matrix degradation and hence, in tumor
invasiveness and metastasis. TIMPs inhibit the proteolytic invasiveness of tumor cells and
normal placental trophoblast cells.
Primary Antibodies
TNF-R2 Rabbit Polyclonal
Toxoplasma Gondii Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4520
0.1ml
Concentrate
Immunogen: Toxoplasma gondii.
Concentrate
C-terminus of mouse TNF-R2.
E4522
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E4524
1.0ml
Concentrate
7.0ml
Ready-to-Use
E4521
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4320
0.1ml
Concentrate
E4322
0.5ml
E4324
E4321
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Toxoplasma Gondii Infected Tissue
Control Tissue: Liver Carcinoma, Thymus
anti-TNF-R2 antibody E432
Human toxoplasma gondii infected brain stained with
anti-T. gondii antibody E452
Product Narrative: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function
is mediated through two distinct cell surface receptors. These receptors, designated
TNF-R1 and TNF-R2, are 55kDa and 75kDa respectively, and are expressed on most cell
types. Signaling through TNF-R2 is confined to cells of the immune system.
Product Narrative: Toxoplasma is as an intracellular parasite in various tissues of
vertebrates and completes its life cycle in a single host. It is transmitted via raw/
undercooked meat, contaminated soil, or by direct contact. Toxoplasma infects tissue
of the GI tract where an active infection is accompanied by fever and enlargement
of the spleen. Symptoms of toxoplasmosis are generally mild. However congenital
toxoplasmosis can produce blindness or mental retardation in the newborn.
Topo II beta Rabbit Polyclonal
TRADD Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4340
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant of human topoisomerase II
beta protein.
E4342
0.5ml
Concentrate
C-terminus of human TRADD.
Application: IHC-P
E4344
1.0ml
Concentrate
Application: IHC-P
E4341
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E4140
0.1ml
Concentrate
E4142
0.5ml
E4144
1.0ml
Concentrate
E4141
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-topo II beta antibody E414
anti-TRADD antibody E434
Product Narrative: Topo II beta plays important roles in synthesis and transcription of
DNA as well as chromosomal segregation during mitosis. It is present ubiquitously in
normal cells and is upregulated in tumors and proliferating cells.
Product Narrative: TRADD (TNF-R1-associated death domain) is an important
mediator of FAS and TNF-r1 associated apoptotic signaling. It contains a death
domain homologous region (DDH) through which it binds to both FAS and TNF-R1.
Overexpression of TRADD causes NFkB activation and apoptosis in absence of TNF.
Topoisomerase I Rabbit Polyclonal
Transforming Growth Factor beta R3 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E11230
0.1ml
Concentrate
Concentrate
region of human topoisomerase I protein.
E11232
0.5ml
Concentrate
Application: IHC-P
E11234
1.0ml
Concentrate
E11231
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18860
0.1ml
Concentrate
E18862
0.5ml
E18864
1.0ml
Concentrate
E18861
7.0ml
Ready-to-Use
Clone: N/A
Immunogen: Recombinant human TGF beta Type III
receptor protein encoding aa 644-850 expressed in
E. coli.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-TGF beta receptor 3 antibody E1123
anti-topoisomerase I antibody E1886
Product Narrative: Topoisomerases are nuclear enzymes involved in chromosome
condensation, DNA replication, transcription, recombination and segregation during
mitosis. Human topoisomerase I is a 100kDa protein capable of relaxing positively
and negatively supercoiled DNA by performing a transient single stranded nick.
Autoantibodies for both DNA topoisomerases I and II were found to be targets of
autoantibodies in the sera of patients with certain autoimmune diseases such as
systemic lupus erythematosus.
Product Narrative: A total of three members of the TGF beta family, TGF beta1, TGF
beta2 and TGF beta3, have been identified in mammals. The type III TGF beta receptor,
also referred to as beta-glycan, confers an additional level of regulation to the TGF
beta signaling system by influencing the affinity with which the TGF betas bind to their
respective receptors.
111
Transforming Growth Factor beta1 (TGFb1) Rabbit Polyclonal
Transforming Growth Factor R1 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E12340
0.1ml
Concentrate
Concentrate
Immunogen: Recombinant protein located in
aa 177-391 of human TGF beta 1.
E12342
0.5ml
Concentrate
Application: IHC-P
E12344
E12341
1.0ml
7.0ml
Concentrate
Ready-to-Use
Catalog No.
Size
Format
E11260
0.1ml
Concentrate
E11262
0.5ml
E11264
1.0ml
Concentrate
E11261
7.0ml
Ready-to-Use
Clone: N/A
internal region of human TGF beta R1.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
anti-TGF β1 antibody E1126
anti-TGF beta1 antibody E1234
beta2 and TGF beta3, have been identified in mammals. TGF betas mediate their
activity by high affinity binding to the type II receptor transmembrane protein with a
cytoplasmic serine/threonine kinase domain.
beta2 and TGF beta3, have been identified in mammals. Each is synthesized as a latent
precursor that is subsequently cleaved forming the 112 amino acid growth factor which
becomes active upon dimerization. TGFbetas mediate their activity by high affinity
binding to the type II receptor 70kDa transmembrane protein with a cytoplasmic serine/
threonine kinase domain.
Transglutaminase II Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4170
0.1ml
Concentrate
Concentrate
region of human TGF beta 2.
E4172
0.5ml
Concentrate
transglutaminase II protein.
Application: IHC-P
E4174
1.0ml
Concentrate
Application: IHC-P
E4171
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E18020
0.1ml
Concentrate
E18022
0.5ml
E18024
1.0ml
Concentrate
E18021
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Cellular Localization: Cytoplasm, Extracellular Matrix,
Membrane
anti-TGF beta 2 antibody E1802
anti-TGase II antibody E417
Product Narrative: Transforming growth factor betas (TGFbs) mediate many cell-cell
interactions that occur during embryonic development. Three TGFbs (TGFb1, TGFb2 and
TGFb3) have been identified in mammals. They are synthesized as precursor proteins
and then cleaved to yield a 112 amino acid polypeptide. This antibody reacts with the
precursor and mature form of TGFb2 and to a lesser extent TGF3, but does not cross
react with TGFb1.
Product Narrative: TGase II is implicated in programmed cell death, signal transduction,
drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract
formation, and wound healing.
TTF-1 Mouse Monoclonal
Clone: N/A
Catalog No.
Size
Format
E17080
0.1ml
Concentrate
Immunogen: Rat TTF-1 recombinant protein.
Concentrate
C-terminus of the precursor form of human TGF beta 3.
E17082
0.5ml
Concentrate
Application: IHC-P
1.0ml
Concentrate
Application: IHC-P
E17084
1.0ml
Concentrate
7.0ml
Ready-to-Use
E17081
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3940
0.1ml
Concentrate
E3942
0.5ml
E3944
E3941
Clone: 8G7G3/1
Isotype: Rabbit IgG
Control Tissue: Lung, Thyroid
anti-TGFβ3 antibody E394
beta2 and TGF beta3, have been identified in mammals. The type III TGF beta receptor,
also referred to as beta-glycan, confers an additional level of regulation to the TGF
beta signaling system by influencing the affinity with which the TGF betas bind to their
respective receptors.
112
anti-TTF-1 antibody E1708
Product Narrative: TTF-1 (Thyroid transcription factor-1) is a member of the NKx2
family of homeodomain transcription factors. It is expressed in epithelial cells of the
thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon,
kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. TTF-1
is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in
colon and breast carcinomas.
Primary Antibodies
TTF-1 Rabbit Polyclonal
Tubulin-gamma Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E10330
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide in the
internal region of human TTF-1 protein.
E10332
0.5ml
Concentrate
C-terminus of human tubulin gamma protein.
E10334
1.0ml
Concentrate
Application: IHC-P
E10331
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19180
0.1ml
Concentrate
E19182
0.5ml
E19184
1.0ml
Concentrate
E19181
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Lung Carcinoma,
Thyroid
anti-tubulin gamma antibody E1033
anti-TTF-1 antibody E1918
Product Narrative: Thyroid transcription factor-1 (TTF-1) is a member of the NKx2 family
of homeodomain transcription factors. It binds and activates the promoter of thyroid
specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. TTF-1
is important in the maintenance of thyroid differentiation and lung development. It is
expressed in epithelial cells of the thyroid gland and the lung, and tumors derived from
such epithelial cells.
Product Narrative: Tubulin gamma, an essential structural protein for cell growth,
organizes microtubule arrays in the nucleus and cytoplasm. Tubulin gamma-depleted
cells fail to form functional spindles and arrest during nuclear division. Tubulin gamma
associates with spindle body components Spc97 and Spc98 to form the tubulin gamma
complex. The phosphorylation of tubulin gamma at Tyr445 plays a regulatory role in
microtubule formation.
Tubulin-alpha Rabbit Polyclonal
Ubiquitin Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E3350
0.1ml
Concentrate
Concentrate
C-terminus of human tubulin alpha.
E3352
0.5ml
Concentrate
Application: IHC-P
E3354
E3351
1.0ml
7.0ml
Concentrate
Ready-to-Use
Catalog No.
Size
Format
E4130
0.1ml
Concentrate
E4132
0.5ml
E4134
1.0ml
Concentrate
E4131
7.0ml
Ready-to-Use
Clone: N/A
ubiquitin protein.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Alzheimer’s Brain, Pancreas
anti-tubulin alpha antibody E413
anti-ubiquitin antibody E335
Product Narrative: Microtubules, the major cytoskeletal elements found in all
eukaryotic cells, consist of tubulin, which is a dimer of two 55kDa subunits: alpha and
beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular
transport, ciliary and flagellar bending, and structural support of the cytoskeleton.
Product Narrative: Ubiquitin (Ub) plays a very important role in regulated nonlysosomal ATP dependent protein degradation. The protein to be degraded is
conjugated to Ub and the ubiquinated protein is then selectively degraded by a 26S
complex, multicatalytic cytosolic and nuclear protease termed proteasome. The Ubproteasome proteolytic pathway, which is a complex process, is implicated to be of great
importance for regulating numerous cellular processes.
Tubulin-beta Rabbit Polyclonal
Urocortin Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
E4480
0.1ml
Concentrate
Concentrate
C-terminus of human tubulin beta.
E4482
0.5ml
Concentrate
C-terminus of urocortin.
Application: IHC-P
E4484
1.0ml
Concentrate
Application: IHC-P
E4481
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E3810
0.1ml
Concentrate
E3812
0.5ml
E3814
1.0ml
Concentrate
E3811
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Lung, Skin
anti-tubulin beta antibody E381
anti-urocortin antibody E448
Product Narrative: Microtubules, the major cytoskeletal elements found in all
eukaryotic cells, consist of tubulin, which is a dimer of two 55kDa subunits: alpha and
beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular
transport, ciliary and flagellar bending, and structural support of the cytoskeleton. This
antibody blocks (by 70-80%) the ability of tubulin dimers (with GppNHp bound) to
promote a stable inhibition of adenylyl cyclase.
Product Narrative: Urocortin (UCN), a neuropeptide widely distributed in the central
nervous system (CNS), belongs to a family of structurally related peptides including
corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived
from a larger precursor protein (pro-urocortin). Urocortin has biological actions similar
to CRF. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by
corticotroph cells from the anterior pituitary.
113
Uroplakin III Rabbit Monoclonal
Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal
Clone: SP73
Catalog No.
Size
Format
N/A
N/A
N/A
Concentrate
C-terminus of human uroplakin III protein.
N/A
N/A
N/A
Application: IHC-P
N/A
M3281
N/A
7.0ml
N/A
Ready-to-Use
Catalog No.
Size
Format
M3730
0.1ml
Concentrate
M3732
0.5ml
M3734
1.0ml
Concentrate
M3731
7.0ml
Ready-to-Use
Clone: SP28
N-terminus of human VEGF.
Application: IHC-P
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Bladder Carcinoma
Membrane
Human bladder transitional cell carcinoma stained with
anti-uroplakin III antibody M373
anti-VEGF antibody M328
Product Narrative: Uroplakins are specific differentiation products of terminally
differentiated superficial urothelial cells. Uroplakin III is expressed in primary and
metastatic urothelial carcinomas.
Product Narrative: VEGF (Vascular Endothelial Growth Factor) is a homodimeric,
disulfide-linked glycoprotein involved in angiogenesis which promotes tumor
progression and metastasis. This antibody reacts with the 165, 189 and 121 amino acid
splice variants of human VEGF.
Uroplakin III Rabbit Polyclonal
Vascular Endothelial Growth Factor (VEGF) Rabbit Polyclonal
Catalog No.
Size
Format
E18240
0.1ml
Concentrate
E18242
0.5ml
Concentrate
E18244
1.0ml
Concentrate
E18241
7.0ml
Ready-to-Use
Clone: N/A
Catalog No.
Size
Format
uroplakin III.
E2610
0.1ml
Concentrate
Clone: N/A
E2612
0.5ml
Concentrate
N-terminus of human VEGF.
E2614
1.0ml
Concentrate
Application: IHC-P
E2611
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Bladder, Bladder Carcinoma
Membrane
Control Lysate: Human Bladder
anti-VEGF antibody E261
Human bladder carcinoma stained with
anti-uroplakin III antibody E1824
Product Narrative: Uroplakins are specific differentiation products of terminally
differentiated superficial urothelial cells. Uroplakin III is expressed in primary and
metastatic urothelial carcinomas.
Product Narrative: VEGF (Vascular Endothelial Growth Factor) is a homodimeric,
disulfide-linked glycoprotein involved in angiogenesis which promotes tumor
progression and metastasis. This antibody reacts with the 165, 189 and 121 amino acid
splice variants of human VEGF.
USF-2 Rabbit Polyclonal
Villin Rabbit Monoclonal
Clone: SP145
Clone: N/A
Catalog No.
Size
Format
M4450
0.1ml
Concentrate
Concentrate
aa 327-346 of mouse USF-2.
M4452
0.5ml
Concentrate
from the C-terminus of human villin protein.
Application: IHC-P
M4454
1.0ml
Concentrate
M4451
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E12560
0.1ml
Concentrate
E12562
0.5ml
E12564
1.0ml
Concentrate
E12561
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Colon, Kidney,
Small Intestine
Cellular Localization: Brush Border,
Cytoplasm
Control Lysate: HT-29
anti-USF-2 antibody E1256
Product Narrative: The ubiquitously expressed cellular upstream stimulatory factor
(USF) consists of 43kDa (USF-1) and 44kDa (USF-2) polypeptides which independently
exhibit site-specific DNA binding and are members of the c-Myc-related family of
regulatory factors containing helix-loop-helix domains. USF also contains a leucine
repeat that is required for efficient DNA binding.
114
anti-villin antibody M445
Product Narrative: Villin is part of cytoskeleton associated with the microvillar actin core
bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and
phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas
of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell
tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.
Primary Antibodies
Villin Rabbit Polyclonal
Vinculin Rabbit Polyclonal
Clone: N/A
Clone: N/A
Catalog No.
Size
Format
Concentrate
Concentrate
C-terminus of human villin.
E18720
0.1ml
Concentrate
E18722
0.5ml
Concentrate
C-terminus of human vinculin protein.
Application: IHC-P
E18724
1.0ml
Concentrate
Application: IHC-P
E18721
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E16640
E16642
0.1ml
0.5ml
E16644
1.0ml
Concentrate
E16641
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Pancreas, Small Intestine
anti-villin antibody E1664
anti-vinculin antibody E1872
Product Narrative: Villin is an actin binding protein expressed mainly in the brush
border of the epithelium in vertebrates. Villin can cap, nucleate, sever and bundle actin
in a Ca2+ and phosphoinositide-regulated manner. Villin is composed of six repeats
that together constitute the core domain. The core domain retains the Ca2+ dependent
capping nucleating and severing activity, whereas the headpiece domain contributes
towards actin filament bundling and binding F-actin.
Product Narrative: Vinculin is a cytoskeletal protein associated with the cytoplasmic
faces of both cell-cell and cell extracellular matrix adherens type junctions. It functions
as one of several interacting proteins involved in anchoring F-actin to the membrane.
Vinculin represents a key element in the transmembrane linkage of the extracellular
matrix to the cytoplasmic microfilament system.
Vimentin Rabbit Monoclonal
Wilm’s Tumor (WT) Rabbit Polyclonal
Clone: N/A
Clone: SP20
Catalog No.
Size
Format
E3990
0.1ml
Concentrate
Concentrate
vimentin protein.
E3992
0.5ml
Concentrate
human Wilm’s tumor protein.
E3994
1.0ml
Concentrate
Application: IHC-P
E3991
7.0ml
Ready-to-Use
Catalog No.
Size
Format
M3200
0.1ml
Concentrate
M3202
0.5ml
M3204
1.0ml
Concentrate
M3201
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Melanoma, Sarcomas
Control Tissue: Wilm’s Tumor
Human Wilm’s tumor stained with
anti-WT1 antibody E399
anti-vimentin antibody M320
Product Narrative: Vimentin is the main intermediate filament protein in mesenchymal
cells. This protein is believed to be involved with the intracellular transport of proteins
between the nucleus and plasma membrane. Vimentin is expressed in sarcomas of
neural, muscle and fibroblast origin, but carcinomas are generally negative. Melanomas,
lymphomas and vascular tumors may express vimentin.
Product Narrative: Wilm’s tumor (WT), a sporadic and familial childhood kidney tumor,
is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a
zinc-finger transcription factor that is essential for the development of the metanephric
kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney
and mesothelioma.
Vinculin Rabbit Monoclonal
WNT-1 Rabbit Polyclonal
Catalog No.
Size
Format
E3960
0.1ml
Concentrate
E3962
0.5ml
Concentrate
from N-terminus of human WNT-1.
Catalog No.
Size
Format
M4170
0.1ml
Concentrate
M4172
0.5ml
Concentrate
C-terminus of human vinculin protein.
Application: IHC-P
E3964
1.0ml
Concentrate
E3961
7.0ml
Ready-to-Use
M4174
1.0ml
Concentrate
M4171
7.0ml
Ready-to-Use
Clone: N/A
Clone: SP117
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Heart, Small Intestine
anti-Wnt-1 antibody E396
anti-vinculin antibody M417
Product Narrative: Vinculin is a muscle-specific cytoskeletal protein associated with the
cytoplasmic faces of both cell-cell and cell extracellular matrix adherens type junctions.
It functions as one of several interacting proteins involved in anchoring F-actin to the
membrane and regulating cell-surface E-cadherin expression. The defect of this protein
can cause dilated cardiomyopathy
Product Narrative: Wnt-1 is a cysteine-rich secreted glycoprotein that associates with
cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1 is
essential for normal development of the embryonic nervous system and its expression is
normally limited to the embryonic neural tube and adult spermatids.
115
XMRV Rabbit Polyclonal
ZO-3 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E17450
0.1ml
Concentrate
Concentrate
Immunogen: Synthetic peptide near N-terminus of
XMRV envelope protein.
E17452
0.5ml
Concentrate
C-terminus of human ZO-3.
Application: IHC-P
E17454
1.0ml
Concentrate
Application: IHC-P
E17451
7.0ml
Ready-to-Use
Catalog No.
Size
Format
E19070
0.1ml
Concentrate
E19072
0.5ml
E19074
1.0ml
Concentrate
E19071
7.0ml
Ready-to-Use
Clone: N/A
Isotype: Rabbit IgG
Isotype: Rabbit IgG
Control Tissue: Prostate Carcinoma with XMRV Infection
anti-XMRV antibody E1907
anti-ZO-3 antibody E1745
Product Narrative: Xenotropic murine leukemia virus-related virus (XMRV) is a newly
recognized human retrovirus first identified in prostate cancer tissues from men with a
deficiency in the innate immunity gene RNASEL. At present, studies have detected XMRV
DNA and protein in prostate cancer at widely different rates and in patients with chronic
fatigue syndrome. The XMRV protein is synthesized in the Golgi by host cells.
Product Narrative: Tight junctions are complexes of proteins between the plasma
membrane domains of epithelial and endothelial cells. ZO-3 forms complexes with ZO-1
and interacts with occludin and claudins. ZO-2 and ZO-3 are ubiquitously expressed
within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell
junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
XRCC2 Rabbit Polyclonal
Clone: N/A
Catalog No.
Size
Format
E4010
0.1ml
Concentrate
E4012
0.5ml
Concentrate
human XRCC2.
Application: IHC-P
E4014
1.0ml
Concentrate
E4011
7.0ml
Ready-to-Use
Isotype: Rabbit IgG
nti-XRCC2 antibody E401
Product Narrative: XRCC2 (X-Ray Cross Complementing 2) is essential for repairing the
double strand DNA breaks by homologous recombination between sister chromatids. It
is homologous to Rad51. Five human homologues of RAD 51; XRCC2, XRCC3, RAD51B,
RAD51C, RAD51D, interact among themselves to form one big complex or several
smaller complexes.
ZAP-70 Rabbit Polyclonal
Catalog No.
Size
Format
E12520
0.1ml
Concentrate
E12522
0.5ml
Concentrate
E12524
1.0ml
Concentrate
E12521
7.0ml
Ready-to-Use
Clone: N/A
ZAP-70.
Isotype: Rabbit IgG
anti-ZAP-70 antibody E1252
Product Narrative: Mutations in ZAP-70 gene results in a form of Severe Combined
Immunodeficiency Syndrome (SCID) in humans. ZAP-70 is also expressed in a subset of
Chronic Lymphocytic Leukemia (CLL).
116
DETECTION AND ANCILLARY PRODUCTS
Spring Bioscience offers a complete
line of detection systems optimized for
immunohistochemistry (IHC) and are
designed to meet the complex needs of
any laboratory.
Featuring:
• Improved signal to noise ratios
• Shorter incubation times
• Works with mouse and rabbit primary
antibodies
REVEAL™ Detection Systems – novel
biotin-free chemistries enable our bestin-class detection systems, including:
• REVEAL HRP DAB System
• REVEAL HRP AEC System
• REVEAL AP Red System
REVEAL™ Best-in-Class Detection Systems
Spring Bioscience’s novel biotin-free detection system, REVEAL™, eliminates the polymer
backbone and allows the enzyme to be conjugated directly to the secondary antibody
by long-arm linkers. The compact size of the molecule enables diffusion through tissue
promoting access to targeted binding sites.
p53 (SP5) Cat# M3054, Colon Adenocarcinoma
p53 (SP5) Cat #M3054, Colon Carcinoma
REVEAL AP Conjugate
REVEAL HRP Conjugate
Leading Competitor’s AP Conjugate
Leading Competitor’s HRP Polymer
Spring REVEAL Biotin-Free Detection Systems
Catalog
Number
118
Product Name
Size
Format
15ml
Ready-to-Use
SPA-015
Reveal - Biotin-Free Polyvalent AEC
SPA-060
60ml
Ready-to-Use
SPA-125
125ml
Ready-to-Use
SPD-015
Reveal - Biotin-Free Polyvalent DAB
15ml
Ready-to-Use
SPD-060
60ml
Ready-to-Use
SPD-125
125ml
Ready-to-Use
PAR-015
Reveal - Biotin-Free Polyvalent AP (Red)
15ml
Ready-to-Use
PAR-060
60ml
Ready-to-Use
PAR-125
125ml
Ready-to-Use
SRA-015
Reveal - Rabbit-Specific AEC
15ml
Ready-to-Use
SRA-060
60ml
Ready-to-Use
SRA-125
125ml
Ready-to-Use
SRD-015
Reveal - Rabbit-Specific DAB
15ml
Ready-to-Use
SRD-060
60ml
Ready-to-Use
SRD-125
125ml
Ready-to-Use
RAR-015
Reveal - Rabbit Specific AP (Red)
15ml
Ready-to-Use
RAR-060
60ml
Ready-to-Use
RAR-125
125ml
Ready-to-Use
MAR-015
Reveal - Mouse Specific AP (Red)
15ml
Ready-to-Use
MAR-060
60ml
Ready-to-Use
125ml
Ready-to-Use
1000ml
Ready-to-Use
MAR-125
SPB-999
Reveal - Polyvalent HRP
Spring Bioscience offers a
complete line of detection
systems optimized for
immunohistochemistry (IHC)
and are designed to meet
the complex needs of
any laboratory.
Detection and Ancillary Products
Biotin-Streptavidin Detection Systems
Catalog
Number
Product Name
Size
Format
TPA-015
Polyvalent HRP AEC Detection System
15ml
Ready-to-Use
TPD-015
Polyvalent HRP DAB Detection System
15ml
Ready-to-Use
TRA-015
Anti-rabbit HRP AEC Detection System
15ml
Ready-to-Use
TRD-015
Anti-rabbit HRP DAB Detection System
15ml
Ready-to-Use
TMA-015
Anti-mouse HRP AEC Detection System
15ml
Ready-to-Use
TMD-015
Anti-mouse HRP DAB Detection System
15ml
Ready-to-Use
HRP-060
Polyvalent HRP Kit
60ml
Ready-to-Use
HRP-125
Polyvalent HRP Kit
125ml
Ready-to-Use
HRP-999
Polyvalent HRP Kit
1000ml
Ready-to-Use
UVX-060
Polyvalent HRP Plus Kit
60ml
Ready-to-Use
UVX-125
Polyvalent HRP Plus Kit
125ml
Ready-to-Use
UVP-060
Polyvalent Alk Phos Kit
60ml
Ready-to-Use
UVP-125
Polyvalent Alk Phos Kit
125ml
Ready-to-Use
Size
Format
Detection Components
Catalog
Number
Product Name
DGP-125
Biotinylated Goat Polyvalent IgG's
125ml
Ready-to-Use
DGP-999
Biotinylated Goat Polyvalent IgG's
1000ml
Ready-to-Use
DGR-125
Biotinylated Goat anti-Rabbit IgG's
125ml
Ready-to-Use
DGM-125
Biotinylated Goat anti-Mouse IgG's
125ml
Ready-to-Use
DSA-125
Streptavidin Alkaline Phosphatase
125ml
Ready-to-Use
DSP-125
Streptavidin Horseradish Peroxidase
125ml
Ready-to-Use
DSP-999
Streptavidin Horseradish Peroxidase
1000ml
Ready-to-Use
Diluent/Buffers/Miscellaneous
Catalog
Number
Product Name
Size
Format
ADC-125
Antibody Diluent UC
125ml
Ready-to-Use
ADP-125
Antibody Diluent UP
125ml
Ready-to-Use
ADS-125
Antibody Diluent
125ml
Ready-to-Use
ADV-060
Antibody Diluent V
60ml
Ready-to-Use
ADV-125
Antibody DiluentV
125ml
Ready-to-Use
PBS-125
PBS (25x) pH 7.6
125ml
Concentrate
PBS-999
PBS (25x) pH 7.6
1000ml
Concentrate
PBT-125
PBS with Tween 20 (20x)
125ml
Concentrate
PBT-999
PBS with Tween 20 (20x)
1000ml
Concentrate
TBS-125
TBS (25x), pH7.4
125ml
Concentrate
TBS-999
TBS (25x), pH7.4
1000ml
Concentrate
TBT-125
TBS with Tween 20 (20x)
125ml
Concentrate
TBT-999
TBS with Tween 20 (20x)
1000ml
Concentrate
DMM-060
Mounting Media
60ml
Ready-to-Use
DMM-125
Mounting Media
125ml
Ready-to-Use
119
Epitope Recovery/Pretreatment Products
Catalog
Number
Product Name
Size
Format
PMB1-125
Antigen Retrieval Buffer 1 (100x) pH=6.0
125ml
Concentrate
PMB1-250
250ml
Concentrate
PMB2-125
125ml
Concentrate
PMB2-250
250ml
Concentrate
PMB3-125
125ml
Concentrate
PMB3-250
250ml
Concentrate
PMB4-125
125ml
Concentrate
PMB4-250
250ml
Concentrate
DCB-125
Citrate Buffer (10x) pH 6.0
125ml
Concentrate
DCBX-050
Citrate Buffer (100x) pH 6.0
50ml
Concentrate
DEB-125
EDTA Buffer (10x) pH 8.0
125ml
Concentrate
DEBX-050
EDTA Buffer (100x) pH 8.0
50ml
Concentrate
DTB-125
Tris Buffer (10x) pH 10.0
125ml
Concentrate
DTBX-050
Tris Buffer (100x) pH 10.0
50ml
Concentrate
DTS-007
Trypsin (2 components)
7ml
Concentrate
DPS-007
Pepsin
7ml
Ready-to-Use
PRK-004
Proteinase K
4ml
Ready-to-Use
Blocking Reagents
Catalog
Number
Size
Format
Hydrogen Peroxide Block
60ml
Ready-to-Use
DHP-125
Hydrogen Peroxide Block
125ml
Ready-to-Use
DPB-060
Protein Block
60ml
Ready-to-Use
DPB-125
Protein Block
125ml
Ready-to-Use
DHP-060
Product Name
BRB-050
Background Reducing Buffer
50ml
Ready-to-Use
DBB-015
Avidin/Biotin Blocking System (2 components)
15ml
Ready-to-Use
Size
Format
AEC Single Solution
60ml
Ready-to-Use
ASS-125
AEC Single Solution
125ml
Ready-to-Use
DAB-060
DAB (2 components, 50x)
60ml
Concentrate
DAB-125
125ml
Concentrate
DAB-999
1000ml
Concentrate
DABD-999
DAB (2 components, 25X)
1000ml
Concentrate
LFR-060
Liquid Fast Red Substrate System (75x)
60ml
Concentrate
LFR-125
125ml
Concentrate
LFR-999
1000ml
Concentrate
LFRD-999
1000ml
Concentrate
Chromogens
Catalog
Number
ASS-060
120
Product Name
ANTIBODY MICROARRAY PRODUCTS
Antibody microarrays provide researchers
the convenience of detecting and analyzing
multiple proteins simultaneously on a
single slide.
Formats Include:
• Master Array (650+ antibodies)
• Arrays by Pathway (Apoptosis, Cell
Cycle, Cytokine and Signal Transduction)
Research Applications Include:
• Protein expression profiling
• Comparison profiles of normal,
diseased, or treated samples
• Identification of candidate biomarkers
Researcher Benefits Include:
• Time savings
• Reduction in reagent costs
• Reduced variability
• Flexible sample preparations (cell
extracts, tissue lysates, treated
samples)
• Built-in control
Array Options to Meet Your Varied Research Interests
Antibody microarrays provide a high-throughput platform for sensitive, efficient and accurate
protein expression profiling, screening and comparison between normal and diseased or
treated samples. Proteins from cell extracts, tissue lysates or treated samples may be used for
analysis and detection. Antibody microarrays enable the qualitative measurement of protein
expression.
Spring’s Master Antibody Microarray kit consists of a set of two slides containing over 650
antibodies printed in duplicate. These high affinity antibodies are well characterized for
immunohistochemistry or Western blot.
Spring’s antibody microarrays by pathway are designed for researchers interested in a specific
field. Each pathway microarray kit contains two identical subarrays (one subarray for normal
sample and another for the treated sample). Each subarray contains 6 replicates of each
antibody. Positive and negative controls are included on each subarray.
Microarray Products
Catalog
Number
122
Product Name
Size
AMD-001
Antibody Microarray Detection Kit
1 kit
AMS-700
Master Antibody Microarray Slides (656 Abs)
2 slides
AAP-100
Apoptosis Microarray Slides (71 Abs)
2 slides
ACC-100
Cell Cycle Microarray Slides (60 Abs)
2 slides
ACK-100
Cytokine Microarray Slides (77 Abs)
2 slides
AST-100
Signal Transduction Microarray Slides (165 Abs)
2 slides
Antibody microarrays
provide researchers the
convenience of detecting
and analyzing multiple
proteins simultaneously on
a single slide.
RECOMBINANT PROTEIN PRODUCTS
Recombinant proteins – expressed in
E. coli and are:
• Full length or partial sequence of
specific proteins
• Fused at N-terminus with GST/His-tag
• Analyzed by SDS-PAGE using coomassie
Blue staining
• Available in 0.1ml (0.1mg/ml) size
124
Catalog
Number
Product Name
Domain
P1094
ALK/p80
aa 426-528
P7014
BCL-6
aa 1-150
P3464
Cadherin E
aa 600-707
P1174
Calretinin
full length
P2824
Cathepsin D
full length
P3044
CD2
aa 25-209
P7044
CD4
aa 26-226
P7979
CD4
aa 207-316
P3024
CD23
aa 48-248
P7122
CD34
full length
P7054
CD68
full length
P3394
CD99
full length
P7982
CD138
aa 18-218
P2444
c-erbB2
aa 537-636
P1524
Chromogranin A
aa 260-454
P7978
c-Met
aa 18-217
P2434
D4GDI
full length
P1644
ER alpha
aa 1-300
P7977
ERCC1
full length
P3644
FHIT
full length
P7127
gp100
aa 1-150
P7113
GST
full length
P7513
IGF-1R
aa 1213-1367
P7861
Involucrin
aa 420-578
P7126
IRF4/MUM1
aa 144-451
P3264
Keratin 8
full length
P7514
LYVE-1
aa 243-323
P7120
MAGE-1
full length
P7522
NY-ESO-1
full length
P7074
p53 mutant (aa135)
full length
P2014
p53 wild type
full length
P2854
PCNA
full length
P3344
PGP9.5
full length
P7125
PPAR gamma
aa 1-477
P2074
aa 412-562
P7935
PSMA
aa 1-150
P7094
PTEN
full length
P2144
S100 beta
full length
P7121
S100A4
full length
P7914
SOX9
aa 1-150
P7874
TGF beta1
aa 177-391
P3354
Ubiquitin
full length
P2944
Vimentin
full length
Product Index
RbMab – SP Clones
Actin-beta Rabbit Monoclonal 14
ALK/p80 Rabbit Monoclonal 16
Androgen Receptor (AR) Rabbit Monoclonal 18
BAX Rabbit Monoclonal 19
BCL-2 alpha Rabbit Monoclonal 19
BOB-1 Rabbit Monoclonal 21
C4d Rabbit Monoclonal 22
Cadherin-E/E-Cadherin Rabbit Monoclonal 23
Cadherin-N/N-Cadherin Rabbit Monoclonal 23
Calcitonin Rabbit Monoclonal 24
Calpain Rabbit Monoclonal 25
Calpastatin Rabbit Monoclonal 25
Calretinin Rabbit Monoclonal 25
Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal 26
Caveolin-1 Rabbit Monoclonal 27
CD3 Rabbit Monoclonal 29
CD44 Std Rabbit Monoclonal 35
CD79a Rabbit Monoclonal 37
CD117/c-kit Rabbit Monoclonal 38
CD278/ICOS Rabbit Monoclonal 40
14-3-3 beta Rabbit Polyclonal 14
14-3-3 zeta Rabbit Polyclonal 14
A
Actin-beta Rabbit Monoclonal 14
Actin-beta Rabbit Polyclonal 14
Actin-Skeletal Muscle Mouse Monoclonal 14
Actin-Skeletal Muscle Rabbit Polyclonal 14
Actin-Smooth Muscle Mouse Monoclonal 15
Actin-Smooth Muscle Rabbit Polyclonal 15
Actin-Smooth Muscle (SMA) Rabbit Monoclonal 15
Adenomatous Polyposis Coli (APC) Rabbit Polyclonal 15
Adrenocorticotrophic Hormone (ACTH) Rabbit Polyclonal 15
Adrenocorticotrophic Hormone (ACTH) Mouse Monoclonal 15
AKT-1/AKT-2 Rabbit Polyclonal 16
AKT-1/PKB (Phospho S473) Rabbit Polyclonal 16
ALK/p80 Rabbit Monoclonal 16
ALK/p80 Rabbit Polyclonal 16
alpha Fetoprotein (AFP) Rabbit Polyclonal 16
alpha-1-Antichymotrypsin Rabbit Polyclonal 17
alpha-1-Antitrypsin Rabbit Polyclonal 17
Amylin Peptide Rabbit Polyclonal 17
Amyloid Precursor Protein (APP) Rabbit Polyclonal 17
Amyloid-beta/Amyloid A4 Rabbit Polyclonal 17
Anaplastic Lymphoma Kinase (ALK) Rabbit Monoclonal 17
Androgen Receptor (AR) Rabbit Monoclonal 18
Androgen Receptor (AR) Rabbit Polyclonal 18
Ki-67 Rabbit Monoclonal 73
LMO2 Rabbit Monoclonal 75
MCM2 Rabbit Monoclonal 77
Mesothelin Rabbit Monoclonal 78
MSH2 Rabbit Monoclonal 80
MUM1/IRF4 Rabbit Monoclonal 83
Myeloperoxidase (MPO) Rabbit Monoclonal 83
Nestin Rabbit Monoclonal 84
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal 85
p120 (catenin delta 1) Rabbit Monoclonal 89
p53 Rabbit Monoclonal 88
PAX-5 Rabbit Monoclonal 90
PI3K p85 Rabbit Monoclonal 93
PLAP Rabbit Monoclonal 94
Progesterone Receptor (PR) Rabbit Monoclonal 96
PSMA Rabbit Monoclonal 97
S6 Ribosomal (Phospho S235/236) Rabbit Monoclonal 100
SLIT2 Rabbit Monoclonal 102
SOX-2 Rabbit Monoclonal 103
Stathmin Rabbit Monoclonal 106
Survivin Rabbit Monoclonal 106
Synaptophysin Rabbit Monoclonal 106
Syntaxin 1A Rabbit Monoclonal 107
Tau (Neuronal Marker) Rabbit Monoclonal 108
Thymidylate Synthase (TS) Rabbit Monoclonal 109
Uroplakin III Rabbit Monoclonal 114
Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal 114
Vimentin Rabbit Monoclonal 115
Vinculin Rabbit Monoclonal 115
CDK2 Rabbit Monoclonal 40
CDX2 Rabbit Monoclonal 41
c-erbB-2/HER-2 Rabbit Monoclonal 42
Chromogranin A Rabbit Monoclonal 43
c-Met Rabbit Monoclonal 45
c-Met (Paired 1003) Rabbit Monoclonal 45
c-Met (Phospho Y1003) Rabbit Monoclonal 46
COX-2 Rabbit Monoclonal 47
c-TEN Rabbit Monoclonal 47
Cyclin D1 Rabbit Monoclonal 48
DOG-1 Rabbit Monoclonal 51
Epidermal Growth Factor Receptor (EGFR) Rabbit Monoclonal 53
ERCC1 Rabbit Monoclonal 54
Estrogen Receptor (ER) Rabbit Monoclonal 55
F4/80 Rabbit Monoclonal 55
FLK-1 (mouse) Rabbit Monoclonal 57
FOXA1 Rabbit Monoclonal 58
FOXP3 Rabbit Monoclonal 59
Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal 61
Glypican-3 Rabbit Monoclonal 63
hENT1 Rabbit Monoclonal 66
IKAROS Rabbit Monoclonal 67
J-chain Rabbit Monoclonal 68
Keratin 5 Rabbit Monoclonal 69
Annexin I Rabbit Polyclonal 18
Annexin VI Rabbit Polyclonal 18
Apoptosis Protease Activating Factor 1 (APAF-1) Rabbit Polyclonal 18
Arginase-1 Rabbit Monoclonal 18
Arginase-1 Rabbit Polyclonal 19
B
BAK Rabbit Polyclonal 19
BAX Rabbit Monoclonal 19
BAX Rabbit Polyclonal 19
BCL-2 alpha Rabbit Monoclonal 19
BCL-2 alpha Rabbit Polyclonal 19
BCL-6 Rabbit Monoclonal 20
BCL-6 Rabbit Polyclonal 20
BCL-10 Rabbit Monoclonal 20
BCL-10 Mouse Monoclonal 20
BCL-X Rabbit Polyclonal 21
BCL-XL Rabbit Polyclonal 21
BCL-XL Mouse Monoclonal 21
BIM/BOD Rabbit Polyclonal 21
Bnip3L Rabbit Polyclonal 21
BOB-1 Rabbit Monoclonal 21
BOB-1 Rabbit Polyclonal 22
Bone Morphogenetic Protein 4 (BMP-4) Rabbit Polyclonal 22
BRAF Rat Monoclonal 22
BRAF B600E Mouse Monoclonal 22
C
C4d Rabbit Monoclonal 22
C4d Rabbit Polyclonal 22
c-Abl Rabbit Polyclonal 23
Cadherin 17 Rabbit Monoclonal 23
Cadherin-E/E-Cadherin Rabbit Monoclonal 23
Cadherin-E/E-Cadherin Mouse Monoclonal 23
Cadherin-E/E-Cadherin Rabbit Polyclonal 23
Cadherin-N/N-Cadherin Rabbit Monoclonal 23
Cadherin-N/N-Cadherin Rabbit Polyclonal 24
Cadherin-pan Rabbit Polyclonal 24
Calbindin D28 Rabbit Polyclonal 24
Calcitonin Rabbit Monoclonal 24
Calcitonin Rabbit Polyclonal 24
Calcium Sensing Receptor (CaSR) Rabbit Polyclonal 24
Calpain Rabbit Monoclonal 25
Calpain Rabbit Polyclonal 25
Calpastatin Rabbit Monoclonal 25
Calpastatin Rabbit Polyclonal 25
Calretinin Rabbit Monoclonal 25
Calretinin Rabbit Polyclonal 25
CaM Kinase IV Rabbit Polyclonal 26
CaM Kinase Kinase alpha Rabbit Polyclonal 26
Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal 26
Carbonic Anhydrase 9 (CA-9) Rabbit Polyclonal 26
125
CAS Rabbit Polyclonal 26
Caspase-1 Rabbit Polyclonal 26
Catenin-beta Rabbit Polyclonal 27
Catenin-gamma Rabbit Polyclonal 27
Cathepsin D Rabbit Polyclonal 27
Caveolin-1 Rabbit Monoclonal 27
Caveolin-1 Rabbit Polyclonal 28
Caveolin-1 Rabbit Polyclonal 28
CCR7 Rabbit Polyclonal 28
CCR8 Rabbit Polyclonal 28
CD1a Rabbit Polyclonal 28
CD2 Rabbit Polyclonal 29
CD3 zeta Rabbit Polyclonal 29
CD34 (Endothelial Cell Marker) Rabbit Polyclonal 34
CD34 (Endothelial Cell Marker) Mouse Monoclonal 34
CD44 Std Rabbit Monoclonal 35
CD44 Std Rabbit Polyclonal 36
CD44 Std Mouse Monoclonal 36
CD45/T200/LCA Mouse Monoclonal 36
CD45RA Mouse Monoclonal 36
CD56 Mouse Monoclonal 36
126
CD79a Rabbit Polyclonal 37
CD95/FAS Rabbit Polyclonal 38
CD99/MIC2 Rabbit Polyclonal 38
CD105/Endoglin/TGF 1/3 Receptor Rabbit Polyclonal 38
CD117/c-kit Rabbit Monoclonal 38
CD117/c-kit Rabbit Polyclonal 38
CD278/ICOS Rabbit Monoclonal 40
CD278/ICOS Rabbit Polyclonal 40
CDC2 p34 Rabbit Polyclonal 40
CDH1 Rabbit Polyclonal 40
CDK2 Rabbit Monoclonal 40
CDK2 Rabbit Polyclonal 41
CDX2 Rabbit Monoclonal 41
CDX2 Rabbit Polyclonal 41
CEA/CD66e Rabbit Polyclonal 41
CEA/CD66e Mouse Monoclonal 41
c-erbB-2 (Paired 1248) Rabbit Polyclonal 41
c-erbB-2 (Phospho Y1248) Rabbit Polyclonal 42
c-erbB-2/HER-2 Rabbit Polyclonal 42
c-Fos Rabbit Polyclonal 43
Cholecystokinin (CCK-8) Rabbit Polyclonal 43
Chromogranin A Rabbit Monoclonal 43
Chromogranin A Rabbit Polyclonal 43
Claudin-1 Rabbit Monoclonal 44
Claudin-1 Rabbit Polyclonal 44
c-Met Rabbit Monoclonal 45
c-Met Rabbit Polyclonal 45
c-Met (Paired 1003) Rabbit Monoclonal 45
c-Met (Paired 1003) Rabbit Polyclonal 45
c-Met (Paired 1349) Rabbit Polyclonal 46
c-Met (Phospho Y1003) Rabbit Monoclonal 46
c-Met (Phospho Y1003) Rabbit Polyclonal 46
c-Met (Phospho Y1234/1235) Rabbit Polyclonal 46
Connexin-43 Rabbit Polyclonal 46
Corticotropin Releasing Factor (CRF) Rabbit Polyclonal 46
COX-1 Rabbit Polyclonal 47
COX-2 Rabbit Monoclonal 47
COX-2 Rabbit Polyclonal 47
CREB-Binding Protein (CBP) Rabbit Polyclonal 47
Cripto-1 Rabbit Polyclonal 47
c-TEN Rabbit Monoclonal 47
c-TEN Rabbit Polyclonal 48
Cullin-1 (CUL-1) Rabbit Polyclonal 48
Cullin-2 (CUL-2) Rabbit Polyclonal 48
CXCR4 Rabbit Polyclonal 48
Cyclin B1 Rabbit Polyclonal 48
Cyclin D1 Rabbit Monoclonal 48
Cyclin D1 Rabbit Polyclonal 49
Cyclin E Rabbit Polyclonal 49
Cyclin E1 Rabbit Monoclonal 49
CYR61 Rabbit Polyclonal 49
Cytochrome C Rabbit Polyclonal 49
D
D4-GDI Rabbit Polyclonal 49
D5DR Rabbit Polyclonal 50
DAPK2 Rabbit Polyclonal 50
Desmin Rabbit Monoclonal 50
Desmin Rabbit Polyclonal 50
DFF-45 Rabbit Polyclonal 50
DHFR Rabbit Polyclonal 50
DJ-1 Rabbit Polyclonal 51
DOG-1 Rabbit Monoclonal 51
DOG-1 Rabbit Polyclonal 51
DOK-1 Rabbit Polyclonal 51
DOK-2 Rabbit Polyclonal 51
DRAK2 Rabbit Polyclonal 51
Dysferlin Rabbit Polyclonal 52
Dystrophin Rabbit Polyclonal 52
Dystrophin Mouse Monoclonal 52
E
E2F-2 Rabbit Polyclonal 52
EGFL7 Rabbit Polyclonal 52
EphA2 Rabbit Monoclonal 52
Ephrin A4 Rabbit Polyclonal 53
Epidermal Growth Factor Receptor (EGFR) Mouse Monoclonal 53
Epidermal Growth Factor Receptor (EGFR) Rabbit Polyclonal 53
ERAB Rabbit Polyclonal 53
ERCC1 Rabbit Monoclonal 54
ERCC1 Rabbit Polyclonal 54
ERCC1 Rabbit Polyclonal 54
ERK-1 Rabbit Polyclonal 54
ERK-2 Rabbit Polyclonal 54
ESA/Ep-CAM Mouse Monoclonal 54
Estrogen Receptor (ER) Rabbit Monoclonal 55
Estrogen Receptor (ER) Rabbit Polyclonal 55
EZH2 Rabbit Monoclonal 55
EZH2 Rabbit Polyclonal 55
F
F4/80 Rabbit Monoclonal 55
F4/80 Rabbit Polyclonal 55
FAS Ligand Rabbit Polyclonal 56
FAS-Associated Phosphatase (FAP-1) Rabbit Polyclonal 56
FcRH5 Rabbit Polyclonal 56
FGFR-1 Rabbit Polyclonal 56
FLI-1 Rabbit Polyclonal 57
FLK-1 (mouse) Rabbit Monoclonal 57
FLK-1/KDR/VEGFR-2 Rabbit Polyclonal 57
FLT-1/VEGFR1 Rabbit Polyclonal 57
FLT-4/VEGFR3 Rabbit Polyclonal 57
Fn14 Rabbit Monoclonal 57
Fn14 Rabbit Polyclonal 58
Product Index
FOXA1 Rabbit Monoclonal 58
FOXA1 Rabbit Polyclonal 58
FOXO1A Rabbit Polyclonal 58
FOXO3A Rabbit Polyclonal 58
FOXP1 Rabbit Polyclonal 59
FPGS Rabbit Polyclonal 59
FRA-2 Rabbit Polyclonal 59
Fragile Histidine Triad (FHIT) Rabbit Polyclonal 60
G
GADD153 Rabbit Polyclonal 60
Gamma Glutamylcysteine Synthetase (GCS) Rabbit Polyclonal 60
GANP Rabbit Polyclonal 60
Gastrin-1 Rabbit Polyclonal 60
GDNF Rabbit Polyclonal 60
GIV Rabbit Polyclonal 61
GIV(pY1765) Rabbit Monoclonal 61
Glial Fibrillary Acidic Protein (GFAP) Rabbit Monoclonal 61
Glial Fibrillary Acidic Protein (GFAP) Rabbit Polyclonal 61
Glial Fibrillary Acidic Protein (GFAP) Mouse Monoclonal 61
Glucagon Rabbit Polyclonal 61
GluR1 Rabbit Polyclonal 62
GluR2/3 Rabbit Polyclonal 62
GluR6/7 Rabbit Polyclonal 62
GLUT-1 Rabbit Monoclonal 62
GLUT-1 Rabbit Polyclonal 62
GLUT-1 Mouse Monoclonal 62
GLUT-3 Rabbit Polyclonal 63
Glutamic Acid Decarboxylase 65 (GAD65) Rabbit Polyclonal 63
Glutamic Acid Decarboxylase 67 (GAD67) Rabbit Polyclonal 63
Glypican-3 Rabbit Monoclonal 63
Glypican-3 Rabbit Polyclonal 63
GNB2 Rabbit Polyclonal 63
GP200 (Renal Cell Carcinoma Marker) Mouse Monoclonal 64
Granzyme B Rabbit Polyclonal 64
GRP75 Rabbit Polyclonal 64
GRSF-1 Rabbit Polyclonal 64
GSK-3 Rabbit Polyclonal 65
Guanylyl Cyclase beta Rabbit Polyclonal 65
Involucrin Rabbit Polyclonal 67
IPO-38 (Proliferation Marker) Mouse Monoclonal 68
IRS-1 Rabbit Polyclonal 68
J
JAB1 Rabbit Polyclonal 68
J-chain Rabbit Monoclonal 68
J-chain Rabbit Polyclonal 68
Jena-Muenchen4 (JM4) Rabbit Polyclonal 68
K
Kappa Light Chain Rabbit Monoclonal 69
Kappa Light Chain (B Cell Marker) Mouse Monoclonal 69
Keratin 5 Rabbit Polyclonal 69
Keratin 18 Mouse Monoclonal 72
Ki-67 Rabbit Monoclonal 73
Ki-67 Rabbit Polyclonal 73
KOC/L523S Rabbit Polyclonal 73
k-Ras Rabbit Polyclonal 73
Ku80 Rabbit Monoclonal 73
Ku80 Rabbit Polyclonal 74
Ku80 Rabbit Polyclonal 74
L
H. Pylori Rabbit Polyclonal 65
H. Pylori Mouse Monoclonal 65
HDAC1 Rabbit Polyclonal 65
HDAC2 Rabbit Polyclonal 65
Heat Shock Protein 60 (HSP60) Rabbit Polyclonal 66
Heat Shock Protein 70 (HSP70) Rabbit Polyclonal 66
hENT1 Rabbit Monoclonal 66
HMGA2 Rabbit Polyclonal 66
Human Growth Hormone (HGH) Rabbit Polyclonal 66
Lambda Light Chain Rabbit Monoclonal 74
Lambda Light Chain Rabbit Polyclonal 74
Lamin B Rabbit Polyclonal 74
Lewis A Mouse Monoclonal 74
LIMD1 Rabbit Polyclonal 75
Lipocalin-2 Rabbit Polyclonal 75
LMO2 Rabbit Monoclonal 75
LMO2 Rabbit Polyclonal 75
LMO2 Mouse Monoclonal 75
Luteinizing Hormone (LH) Rabbit Monoclonal 75
Luteinizing Hormone (LH) Rabbit Polyclonal 76
I
M
ID2 Rabbit Polyclonal 66
ID3 Rabbit Polyclonal 67
IKAROS Rabbit Monoclonal 67
IKAROS Rabbit Polyclonal 67
Inhibin-alpha Rabbit Polyclonal 67
Integrin beta 5 Rabbit Polyclonal 67
MAGE-1 Rabbit Polyclonal 76
MALT-1 Rabbit Polyclonal 76
MAP4K4 Rabbit Monoclonal 76
MART-1/Melan-A Rabbit Polyclonal 76
MCL-1 Rabbit Polyclonal 76
MCM2 Rabbit Monoclonal 77
H
MCM2 Rabbit Polyclonal 77
MDGI Rabbit Polyclonal 77
MDGI Rabbit Polyclonal 77
MEF-2 Rabbit Polyclonal 78
Melanoma (gp100) Rabbit Polyclonal 78
Mesothelin Rabbit Monoclonal 78
Mesothelin Rabbit Polyclonal 78
mGluR1 Rabbit Polyclonal 78
mGluR5 Rabbit Polyclonal 78
Microphthalmia (MiTF) Rabbit Polyclonal 79
MIP-1 alpha Rabbit Polyclonal 79
MLH1 Rabbit Polyclonal 79
MMP-1 Rabbit Polyclonal 79
MMP-2 (72kDa Collagenase IV) Rabbit Polyclonal 79
MMP-3 (Stromelysin-1) Rabbit Polyclonal 79
MMP-9 (92kDa Collagenase IV) Rabbit Polyclonal 80
MMP-14/MT1-MMP Rabbit Polyclonal 80
MMP-15/MT2-MMP Rabbit Polyclonal 80
MSH2 Rabbit Polyclonal 81
MSH6 Mouse Monoclonal 81
mTOR Rabbit Polyclonal 81
mTOR Rabbit Polyclonal 82
MUC-1 Underglycosylated Mouse Monoclonal 82
MUC-1/EMA/Epithelial Membrane Antigen Rabbit Polyclonal 82
MUC-1/EMA/Epithelial Membrane Antigen Mouse Monoclonal 82
Mucin 5AC Mouse Monoclonal 82
Mucin-2/MUC-2 Mouse Monoclonal 82
MUM1/IRF4 Rabbit Monoclonal 83
MUM1/IRF4 Rabbit Polyclonal 83
Myeloperoxidase (MPO) Rabbit Monoclonal 83
Myeloperoxidase (MPO) Rabbit Polyclonal 83
Myoglobin Rabbit Polyclonal 83
N
NCK2 Rabbit Polyclonal 83
Negative Control for Rabbit IgG Rabbit Monoclonal 84
Nephrin Rabbit Polyclonal 84
Nestin Rabbit Monoclonal 84
Nestin Rabbit Polyclonal 84
Nestin Rabbit Polyclonal 84
Neuron Specific Enolase (NSE) Rabbit Polyclonal 84
NFkB p50 Rabbit Polyclonal 85
NFkB p65 Rabbit Polyclonal 85
Nitric Oxide Synthase-Endothelial (eNOS) Rabbit Polyclonal 85
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Monoclonal 85
Nitric Oxide Synthase-Inducible (iNOS) Rabbit Polyclonal 85
Nitric Oxide Synthase-Universal (uNOS) Rabbit Polyclonal 85
NKX3.1 Rabbit Polyclonal 86
Notch-1 Rabbit Polyclonal 86
N-Ras (Q61R) Rabbit Monoclonal 86
NRF2 Rabbit Polyclonal 86
O
Occludin Rabbit Polyclonal 86
OCT-1 Rabbit Polyclonal 86
OCT-2 Rabbit Polyclonal 87
127
OCT-3/OCT-4 Rabbit Polyclonal 87
OCT-3/OCT-4 Rabbit Polyclonal 87
Osteopontin Rabbit Polyclonal 87
P
p14ARF Rabbit Polyclonal 87
p27Kip1 Rabbit Polyclonal 87
p300/CBP Rabbit Polyclonal 88
p53 Rabbit Polyclonal 88
p53 Mouse Monoclonal 88
p57 Rabbit Polyclonal 89
p70S6k Rabbit Polyclonal 89
p70S6k (Paired 421/424) Rabbit Polyclonal 89
p70S6k (Phospho T421/S424) Rabbit Polyclonal 89
p120 (catenin delta 1) Rabbit Monoclonal 89
p120 (catenin delta 1) Rabbit Polyclonal 89
PAK alpha Rabbit Polyclonal 90
Parathyroid Hormone Rabbit Polyclonal 90
Parathyroid Hormone Receptor 1 Rabbit Polyclonal 90
Parkin Rabbit Polyclonal 90
PAX-5 Rabbit Monoclonal 90
PAX-5 Rabbit Polyclonal 91
Paxillin Rabbit Polyclonal 91
PCNA Rabbit Monoclonal 91
PCNA Rabbit Polyclonal 91
PD-1/CD279 Rabbit Polyclonal 91
PD-1/CD279 Rabbit Polyclonal 91
PDCD6 Rabbit Polyclonal 92
PDGFR alpha Rabbit Polyclonal 92
PDGFR beta Rabbit Polyclonal 92
PDK-1 Rabbit Polyclonal 92
PDS-1/Securin Rabbit Polyclonal 92
Peripheral Myelin Protein (PMP-22) Rabbit Polyclonal 92
Phospho-Ser/Thr/Tyr Mouse Monoclonal 93
Phosphotyrosine Mouse Monoclonal 93
PI3K p110beta Rabbit Polyclonal 93
PI3K p85 Rabbit Monoclonal 93
PI3K p85 Rabbit Polyclonal 93
PI3KCA Rabbit Monoclonal 93
PIM-1 Rabbit Polyclonal 94
PIM-2 Rabbit Polyclonal 94
Placental Lactogen (hPL) Rabbit Polyclonal 94
PLAP Rabbit Monoclonal 94
PLAP Rabbit Polyclonal 94
PLC beta 1 Rabbit Polyclonal 94
PLC gamma 2 Rabbit Polyclonal 95
Pleiotrophin Rabbit Polyclonal 95
PML Rabbit Polyclonal 95
PMS2 Rabbit Polyclonal 95
Poly ADP-Ribose Polymerase (PARP) Rabbit Polyclonal 95
Presenilin Rabbit Polyclonal 95
Progesterone Receptor (PR) Rabbit Polyclonal 96
Prohibitin Rabbit Polyclonal 96
Prolactin Rabbit Polyclonal 96
Prostate Apoptosis Response 4 (PAR-4) Rabbit Polyclonal 96
Prostate Specific Antigen (PSA) Rabbit Polyclonal 97
Prostate Stem Cell Antigen (PSCA) Rabbit Polyclonal 97
Protein Gene Protein 9.5 (PGP9.5) Rabbit Polyclonal 97
PSMA Rabbit Monoclonal 97
PSMA Rabbit Polyclonal 97
128
R
T
RACK-1 Rabbit Polyclonal 97
RAD51 Rabbit Polyclonal 98
RAN Rabbit Polyclonal 98
RCAS1 Rabbit Polyclonal 98
RCC1 Rabbit Polyclonal 98
Retinoblastoma (Rb) Rabbit Polyclonal 98
Retinoic Acid Receptor beta Rabbit Polyclonal 98
Retinoic X Receptor gamma Rabbit Polyclonal 99
RHO Rabbit Polyclonal 99
ROC1 Rabbit Polyclonal 99
RRM1 Rabbit Monoclonal 99
RRM1 Rabbit Polyclonal 99
Tau (Neuronal Marker) Rabbit Monoclonal 108
Tau (Neuronal Marker) Rabbit Polyclonal 108
TdT Rabbit Polyclonal 108
Terminal Deoxynucleotidyl Transferase (TdT) Rabbit Monoclonal 108
Thioredoxin Reductase 2 (TrxR2) Rabbit Polyclonal 108
Thrombin R/ATAP2 Rabbit Polyclonal 108
Thymidylate Synthase (TS) Rabbit Monoclonal 109
Thymidylate Synthase (TS) Rabbit Polyclonal 109
Thymidylate Synthase (TS) Rabbit Polyclonal 109
Thyroglobulin Mouse Monoclonal 109
Thyroid Hormone Receptor alpha1/alpha2 Rabbit Polyclonal 109
Thyroid Hormone Receptor beta Rabbit Polyclonal 109
Thyroid Stimulating Hormone (TSH) Rabbit Polyclonal 110
Thyroid Transcription Factor-1 (TTF-1) Rabbit Monoclonal 110
TIE-1 Rabbit Polyclonal 110
TIMP-1 Rabbit Polyclonal 110
TNF-R2 Rabbit Polyclonal 111
Topo II beta Rabbit Polyclonal 111
Topoisomerase I Rabbit Polyclonal 111
Toxoplasma Gondii Rabbit Polyclonal 111
TRADD Rabbit Polyclonal 111
Transforming Growth Factor beta R3 Rabbit Polyclonal 111
Transforming Growth Factor beta1 (TGFb1) Rabbit Polyclonal 112
Transforming Growth Factor R1 Rabbit Polyclonal 112
Transglutaminase II Rabbit Polyclonal 112
TTF-1 Mouse Monoclonal 112
TTF-1 Rabbit Polyclonal 113
Tubulin-alpha Rabbit Polyclonal 113
Tubulin-beta Rabbit Polyclonal 113
Tubulin-gamma Rabbit Polyclonal 113
S
S100 Rabbit Polyclonal 99
S100 beta Rabbit Monoclonal 100
S100A4 Rabbit Polyclonal 100
S6 Ribosomal Rabbit Polyclonal 100
S6 Ribosomal (Paired 235/236) Rabbit Polyclonal 100
S6 Ribosomal (Paired 240/244) Rabbit Polyclonal 100
S6 Ribosomal (Phospho S235/236) Rabbit Polyclonal 101
S6 Ribosomal (Phospho S240/244) Rabbit Polyclonal 101
SHIP-1 Rabbit Polyclonal 101
SH-PTP2 Rabbit Polyclonal 101
SKP1 p19 Rabbit Polyclonal 101
SKP2 p45 Rabbit Polyclonal 102
SLIT2 Rabbit Monoclonal 102
SLIT2 Rabbit Polyclonal 102
SMA Rabbit Polyclonal 102
SMAD3 Rabbit Polyclonal 102
SMRTe Rabbit Polyclonal 102
SOCS-2 Rabbit Polyclonal 103
Sodium Channel-pan Rabbit Polyclonal 103
Sonic Hedgehog Rabbit Polyclonal 103
SOX-2 Rabbit Monoclonal 103
SOX-2 Rabbit Polyclonal 104
SP1 Rabbit Polyclonal 104
Spink1 Rabbit Monoclonal 105
ST13 Rabbit Polyclonal 105
Stanniocalcin-2 Rabbit Polyclonal 105
STAT3 Rabbit Polyclonal 105
STAT5 alpha Rabbit Polyclonal 105
STAT6 Rabbit Polyclonal 105
Stathmin Rabbit Monoclonal 106
Stathmin Rabbit Polyclonal 106
Survivin Rabbit Monoclonal 106
Survivin Rabbit Polyclonal 106
SYK Rabbit Polyclonal 106
Synaptophysin Rabbit Monoclonal 106
Synaptophysin Rabbit Polyclonal 107
Syntaxin 1A Rabbit Monoclonal 107
Syntaxin 1A Rabbit Polyclonal 107
Synuclein-alpha Rabbit Polyclonal 107
Synuclein-beta Rabbit Polyclonal 107
Synuclein-pan Rabbit Polyclonal 107
U
Ubiquitin Rabbit Polyclonal 113
Urocortin Rabbit Polyclonal 113
Uroplakin III Rabbit Monoclonal 114
Uroplakin III Rabbit Polyclonal 114
USF-2 Rabbit Polyclonal 114
V
Vascular Endothelial Growth Factor (VEGF) Rabbit Monoclonal 114
Vascular Endothelial Growth Factor (VEGF) Rabbit Polyclonal 114
Villin Rabbit Monoclonal 114
Villin Rabbit Polyclonal 115
Vimentin Rabbit Monoclonal 115
Vinculin Rabbit Monoclonal 115
Vinculin Rabbit Polyclonal 115
W
Wilm’s Tumor (WT) Rabbit Polyclonal 115
WNT-1 Rabbit Polyclonal 115
X
XMRV Rabbit Polyclonal 116
XRCC2 Rabbit Polyclonal 116
Z
ZAP-70 Rabbit Polyclonal 116
ZO-3 Rabbit Polyclonal 116
CORPORATE OFFICE
6920 Koll Center Parkway, Suite 211
Pleasanton CA 94566 USA
Email: [email protected]
Telehone: +1.925.474.8440
Toll Free: 800.787.6896
Fax: +1.925.474.8469
www.springbio.com
US CUSTOMERS
[email protected]
INTERNATIONAL CUSTOMERS
[email protected]
TECHNICAL SUPPORT
Telephone: +1.925.474.8479
Email: [email protected]
For Research Use Only. Not for use in diagnostic procedures.
© 2013, Spring Bioscience Corporation. Spring Bioscience, the logo and REVEAL
are trademarks of Spring Bioscience Corporation. All rights reserved.

the Spring Bioscience Antibody Catalog.

Transcription

Similar documents

White Light - Compagnie Papier Plum

Please click here for a downloadable brochure

A P O C A L I P P O

Rabbit moved into a small hotel room above the bar. The room was

the velveteen rabbit agenda

how to hold and cuddle your dwarf rabbit

Bunny 101 - Rabbit Advocates

Stories spread throughout the city of how violent the Sloth`s bar was

Summer Reading 1 - Edgartown School

Rossini 3SE THE RABBIT OF SEVILLE “I Think I`m in Love with You