ZIAUDDIN MEDICAL UNIVERSITY

Transcription

ZIAUDDIN MEDICAL UNIVERSITY
4
ISSUED BY: REGISTRARS OFFICE, MAY 2014
FIRST YEAR
SEMESTER 2 |MAY 2014 - SEPTEMBER 2014|
CONTENTS
S. No.
Page
1.
Introduction
2
2.
Learning Methods
3
3.
Examination Rules
7
4.
Test Administration Rules & Regulations
11
5.
Whom to Contact
13
6.
Management
14
7.
Course Objectives & Strategies
Module – 1
Respiratory System
15
Module – 2
Inferential Biostatistics
20
Module – 3a
Haemopoietic System
Module – 3b
Immune System
22
25
8.
Learning Resources
27
9.
Student Code of Conduct
29
10.
Schedule
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INTRODUCTION
Why Study Guide?
To inform students how student-learning programme has been organized
semester wise, and how it would be implemented.
To help students organize and manage their studies throughout the year.
What is a Study Guide Book ?
(Figure selected from AMEE Medical Education
Guide #16)
The Guide provides:
Information on organization and management of the semester. This will help you
to contact the right individual in case you have any difficulty.
A description of the module objectives which you will be expected to achieve
at the end of each module.
Information on learning methods that you will experience during the module.
The methods include: Problem-Based Learning (PBL), tutorials (SG), lectures, skills/
practicals and field visits. These learning methods should help you achieve the
module objectives.
A description of the learning resources available for the Semesters. These
include: books, Computer Assisted Learning Programmes, videos and others.
Information on the contribution of continuous and semester examinations and
your overall performance.
Information on the methods of assessment that will be held to determine your
achievement of objectives.
Information on examination policy, rules and regulations.
The Curriculum:
It is integrated comprising of system based modules
Curriculum Organization :
Consists of following for each module and generic courses
Course No
Duration of Semester and Modules
Objectives of each module
Learning Strategies
Number of Hours
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Ziauddin University
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Test Schedule / CAT & Semester.
Semester Schedule.
LEARNING METHODS
The following teaching / learning methods/strategies are used to promote better
understanding:
Problem Based Learning (PBL)
Tutorials
-Field Visits
-Lectures
Hospital Visits
-Seminars
Practicals
-Assignments
Computer Assisted Learning Program (CALP)
Case- Based Sessions (CBS)
Small Group Sessions (SGS)
The programme emphasis is on:
Problem-Based Learning:
This is a small group activity in which the discussion revolves around a real life
problem using the Seven Jump process. Students are expected to consult
various learning resources to develop better understanding of the subject.
Self-Directed Study:
Students may achieve the Objectives by assuming responsibilities of their own
learning. How? By sharing and discussing with peers, working individually, seeking
information from LRC, teachers and resource persons within and outside the
college. This is possible by utilizing scheduled self -study period in college, and
time outside the college.
Community-Based Learning Activities:
This takes place within a community including homes of individuals, families, and
a variety of health service settings.
Family assignment is an integral component of this activity. The Department of
Family Medicine monitors students’ activity, and provide constructive feedback.
PROBLEM-BASED LEARNING (PBL): WHAT IS IT?
It is a method of learning in which learners (students) in small groups first
encounter a problem, which are close to real life situations. The problem is
generally discussed in two sessions.
First Session: Learners in small groups, using existing knowledge, discuss (in the
presence of a tutor) and list what they do not know or are not sure of, about the
problem. The list is known as learning issues (goals).
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Self Study: Learners have approximately three days time to report. During this
time, learners search for new information required to achieve the learning goals
listed. In this process, learners are encouraged to consult various learning
resources in addition to the textbooks. This does not require a tutor.
Second Session: Learners discuss learning issues and application of new
knowledge to the problem and summarize by integrating prior and new
knowledge in understanding the problem.
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EXAMPLE OF PBL SCENARIO:
A 1½ year old male was brought to the OPD by his father with complaints of a swelling
in the right groin since birth.
Birth History:
He was born at 34 weeks’ gestation. His birth weight was 2 kg.
PHYSICAL EXAMINATION:
BP:
100/60mmHg
Pulse:
86/min
Temp:
98oF
R/R:
15/min
Local Examination:
Left testis is palpable in the scrotum.
Right testis could not be palpated in the scrotum.
A 1x1 inch oval, firm, non-tender mass was present in the right inguinal region.
Lab:
Serum testosterone level: 110 ng/dl
Ultrasound:
Showed an ovoid homogenous medium-level echogenicity within the right inguinal canal.
The parent was counseled about the prevalence of the condition.
Orchidopexy was advised.
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PBL PROCESS
JUMP 1
Read the Problem:
Clarify terms not known
to you in the problem description
The
JUMP 2
Define the problem.
Draw up a list of
phenomena that need to be explained
Seven
Jumps
JUMP 3
Explain the problem
Try to produce as many different
explanations for the phenomena
as you can think of
JUMP 4
Arrange the explanations
Proposed in a logical sequence
and summarize them
JUMP 5
Formulate learning goals:
make a list of what you need to
study in order to solve the problem
JUMP 6
Through individual study, attempt
to fill the gaps in your knowledge
JUMP 7
Summarize the information
collected and verify it by
applying it to the problem
Evaluation
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EXAMINATION RULES
In one academic year there will be two semesters each followed by an
examination.
At the end of the academic year there will be resit examinations for 1st and
2nd semester courses.
A student passing in 1st semester will be allowed to go to 2nd semester.
Those failing in courses of 1st semester will also be allowed to join 2nd
semester classes but will appear in the resit exam for the required courses
held at the end of the academic year.
Students failing in the 2nd semester will also appear in the resit exam at the
end of the year.
Students failing to achieve required aggregate after the resit of 1st or 2nd
semester courses / subjects will repeat the year.
There will be external examiners in all semester examinations and resits.
2. ASSESSMENT: MOST FREQUENTLY ASKED QUESTIONS
(i) CONTINUOUS ASSESSMENT
Q. Are tests scheduled throughout both semesters? YES
Q. What contribute to continuous assessment in Semesters I and II?
Scheduled test/s for every module during the semester
PBL, assignments, presentations (may not necessarily be all)
Q.
In tests and semester examinations, what methods are used to assess
knowledge and skills?
MCQs: One best/ true false.
Structured cased based viva voice
Practicals and Objective Structured Practical Examinations
(OSPE)
Q. What is the passing mark or score for tests and semester examinations?
Fifty-five percent (55%).
Q. What is the grading system?
Satisfactory (S)
60% and above
Satisfactory Borderline (S*)
55 to 59%
Unsatisfactory Borderline (US*)
50-54%
Unsatisfactory (US)
Below 50%
Q. Are the students notified of the marks in tests and semester examinations and
receive feedback of their progress?
Marks are not notified but Results are notified in semesters of S, S*, US, or
US*
Students receive feedback on written tests of MCQs.
Q. How is the result compiled of Semesters One and Two?
According to duration, and importance, every module may have one to
three tests which carry a defined weightage. Test marks are totaled
according to the weightage.
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The following EXAMPLE may help you understand how Continuous Assessment
result is compiled.
Weightage for Continuous Assessment (Sample)
Test
PBL
Total
75%
25%
100%
Note: Quizzes etc may be scheduled by individual module Coordinator, which
may not contribute towards your aggregate score.
Q. Is there a final or annual examination? No
There are two semester examinations for 1st year MBBS – Semester I & II.
Q. Are all enrolled students eligible to take the Semester examination?
No Eligibility is determined as follows:
Attendance
Cont.
Assess.
1
Decision
Eligible for Semester
2
75-80%
Eligible for Semester
3
60 – 75%
Eligible for Re-sit
4
<60%
Any score
Repeats the year*
5
Any value
<35%
Repeats the year*
*Note:
To decide about repeating the year
cumulative scores for two semesters is
considered(Attendance and
Continuous Assessment)
Q.Does continuous assessment has any credit or contributes towards the Semester
Examination?
Yes (20%).
Q. Who is declared Satisfactory?
Student is declared Pass if,
o He/she scores an aggregate of 55% cumulative in each semester.
AND
o Scores a minimum of 50% in each subject.
Note: If student score an aggregate of 55% in the two semesters, but in any individual
subject scores <50%, then cumulative score of that subject in both semesters will be
considered to declare him satisfactory.
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Q. What happens if a student is unable to sit for the Semester Examination?
He/she is allowed to take the resit examination which will be considered
as second chance.
Q .What happens if a student is unable to sit for the Resit Examination?
The student will be allowed to repeat the year provided he/she has
cleared at least one semester for that year. If the student has not cleared
both the semester and the resits he/she will be asked to withdraw.
WITHDRAWAL FROM THE PROGRAM
A student of first and second year will have to withdraw from the program if he/she
fails to pass both semester examinations of any year, within 2 years (4 attempts)
TEST ADMINISTRATION RULES and REGULATIONS
GENERAL RULES:
All tests /examinations are monitored by the Department of Examination with the
support of the College Dean/Principal, faculty and staff.
To ensure that the examinations are held according to the standard conditions
and that no examinee or group of examinees receives unfair advantage in the
examination, Students (examinees) must strictly adhere to / abide by the rules
and regulations of the University.
IRREGULAR BEHAVIOR
Specific examples of irregular behavior include, but are not necessarily limited to
the following:
1. Copying answers from another examinee or allowing answers to be copied.
2. Making notes of any kind during an examination.
3. Failure to follow instructions of the staff present in the examination hall.
4. Acts of disruptive behavior such as raising ones voice, talking to others,
interrupting the examination process upon entering the examination hall, or
during an examination and other similar acts of behavior.
5. During an examination usage of any unauthorized material such as
photographic equipment, communication or recording devices, including
electronic paging devices and cellular telephones.
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6. Altering or misrepresenting examination result, theft or unauthorized
possession of examination materials.
7. Memorizing and reproducing examination materials and any unauthorized
reproduction by any means and / or dissemination of examination materials.
8. Looking in the direction of another examinee, passing of written notes,
leaving written notes on vacant seats/ desks not occupied by examinees
during the examination may be considered as evidence of copying or
attempting to copy and a report of such behavior may result in irregular
behavior.
9. Sitting for an examination without being eligible for it, impersonating an
examinee or engaging a proxy to take the examination.
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TEST ADMINISTRATION RULES AND REGULATIONS
Advice for Students: What to do?
Students should arrive at the examination hall before scheduled time.
Students arriving within 10 minutes after scheduled test time may be admitted
only by the approval of head examiner or official of the Department of
Examination. Incase a student arrives late, that is, after scheduled time, he / she
is not to be admitted.
2. Students should present College Identity Card and Admit Card for Annual / Resit
Examinations. If student/s does not bring the required Identification Card, he /
she may not be admitted to the examination.
1.
Advice for Students: What NOT to do?
1.
Do not bring into the examination hall any personal belongings, including
mechanical or electrical devices, backpacks, handbags, books, notes or
study guide materials, calculators, digital watches, watches with computer
communication and/ or memory capability, electronic paging devices,
recording or filming devices, radios, cellular telephones, food and drinks.
Only for specified subject/s special instruction will be given on use of
calculator for examination.
Do not make written notes or record in anyway the contents of an
examination.
3. Any notes found will be confiscated and reported for disciplinary action.
2.
Do not communicate with, seek aid from, or provide aid to any other
examinee during the examination.
5. Once you (students) start taking an examination, you cannot cancel that
examination.
4.
6.
If the test is completed in less than the time allotted then do not leave
without seeking permission from the staff present in the examination hall.
No extra time will be allowed if he /she leave the examination hall for
any reason.
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WARNING
`
STUDENTS (EXAMINEES) OBSERVED IN ACT/S THAT
IS/ARE POSSIBLE VIOLATION OF TEST ADMINISTRATION
RULES OR OTHER FORMS OF IRREGULAR BEHAVIOR
DURING AN EXAMINATION WILL BE REPORTED
TO THE DISCIPLINARY COMMITTEE FOR ACTION.
ALL STUDENTS FOUND INVOLVED IN INDISCIPLINARY
ACTION IN THE UNIVERSITY PREMISES (INCLUDING
SMOKING) WILL BE SUBJECTED TO DISCIPLINARY ACTION
WHICH MAY BE IN FORM OF DEDUCTION IN ATTENDANCE
FIVE CONSECUTIVE ACADEMIC SESSIONS.
DRESS CODE:
o WEARING WHITE COAT IS MANDATORY IN ALL
CLINICAL AND LAB SESSIONS.
o DRESS SHOULD BE DECENT AND FORMAL FOR BOTH
BOYS & GIRLS.
o SLIPPERS ARE NOT ALLOWED.
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WHOM TO CONTACT?
Any queries or difficulties with the schedule, learning strategy should be directed:
In the first instance to the individual, teacher or module coordinator and then to
Semester In-charge.
Contacts:
Semester Incharge
Dr. Zil-e-Rubab
Dean Ziauddin Medical College
Dr. Kamran Hameed
Controller of Examinations
Dr. Owais Ismail
Registrar:
Mr. Mohammad Yousuf
ZU Literary and Cultural Society
Dr. Saeeda Baig
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MANAGEMENT/ ORGANIZATION
Semester Incharge:
Dr. Zil-e-Rubab
Professor, Department of Biochemistry
Course Name
Coordinator
Respiratory System
Dr Iffat Raza
Inferential Biostatistics
Dr Nosheen Zehra
Haemopoietic & Immume System
Dr. Fauzia Perveen
Other Team Members
Dr. Fouzia Shaikh
Ms. Areeba Qamar
Dr. Sofia Amjad
Dr. Sameena Mohiuddin
Dr. Shehla Shaheen
Dr. Santosh Kumar
Dr. Arsalan Manzoor
Dr. Saniya Farrukh
Dr. Najia Tabassum
Dr. Madiha Sadiq
Dr. Bilal Aheed
Dr. Nazia Moin
Mr. M. Haris Lucky
Dr. Fatima Ali Raza Mughal
Dr. Ghazala Farrukh
Dr. Irrum Faisal ( E )
Dr. Maria Mohiuddin
Dr. Ali Nawaz Bijrani ( E )
Dr. Sabeen Akbar Yezdani (E)
Resource Persons:
Basic Health Sciences:
Anatomy
Prof. Ishrat Shokh
Prof. Nuzhat Hassan
Dr Bushra Waseem
Dr Kevin Borges
Dr Arsalan Manzoor
Biochemistry
Prof. Saeeda Baig
Prof. Zil-e-Rubab
Dr. Shamim
Physiology
Prof. Syed Touseef Ahmed
Dr. Sadaf Fatima
Dr. Sofia Amjad
Pathology
Pharmacology
Prof. Serajuddaula Syed
Prof. Qamar Jamal
Prof. Naila Hadi
Dr. Fouzia Shiekh
Dr. Faraz Baig
Dr. Najia
Prof. Zahida Memon
Prof.Samia Pervaiz
Prof. Owais Ismail
Dr. Shehla Shaheen
Community Health Sciences:
Prof.Shahida Rasheed
Dr. Farah Ahmad
Dr. Nosheen Zehra
Dr. Hassan Danish
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COURSE NO: 212
COURSE: RESPIRATORY SYSTEM
Objectives:
At the end of the course students should be able to: 1. Describe the microscopic structure of Respiratory Tract and Respiratory
Membrane on slides.
2. Explain the gross structure, neurovascular supply, lymphatic drainage and
functions of:
- Upper Respiratory Tract
a. Nose - Paranasal Sinuses
b. Pharynx - Larynx - Trachea
- Lower Respiratory Tract
a. Bronchial Tree
b. Lungs
c. Pleura
3. Describe the development, gross structure, neurovascular supply and functions
of diaphragm.
4. Describe the development of respiratory system and the underlying
developmental mechanism of the following:
a. Tracheoesophageal fistula
b. Respiratory distress syndrome (of newborn)
5. Describe the formation and functions of surfactant.
6. Describe the etiology, pathogenesis and natural history of the disease of
respiratory distress syndrome.
7. Relate the diffusion of gases and mechanism of pulmonary ventilation to the
structure of the lung and thoracic cage, with specific reference to work of
breathing and compliance of lungs.
8. Differentiate between normal and abnormal pulmonary volume, capacity and
pulmonary function tests in a given set of data.
9. Interpret normal and abnormal in a given set of different values of the partial
pressure of respiratory gases.
10. Differentiate between normal and abnormal in a given set of ventilation
perfusion ratio curves.
11. Analyze the cases of following diseases with reference to etiology,
pathogenesis, diagnostic workup, risk factors, and preventive strategies.
a. Restrictive lung diseases
b. Obstructive lung diseases
c. Common Respiratory tract infections
d. Tumors of lungs and pleura.
e. ARDS / NRDS
f. Pneumonia
g. Pulmonary Tuberculosis
h. Diseases of nose,sinuses, nasopharynx. and larynx.
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12. Classify the drugs used for the treatment and prophylaxis of asthma according
to their mechanism of action.
13. Describe their adverse effects, contraindications and common drug –drug
interaction.
14. Describe the mechanism of action and adverse effects of antitussives and
mucolytic agents.
15. Explain the mechanism of transportation of oxygen and carbon dioxide in
blood.
16. Correlate the factors involved in the production of abnormal curve in a given set
of oxygen hemoglobin dissociation curves.
17. Explain Carbon dioxide and Carbon monoxide - Hb dissociation curve on the
basis of its effects on binding of oxygen with hemoglobin.
18. Describe the mechanism of regulation of respiration (neural and chemical) on
the following conditions:
a. Exercise
b. High altitude
c. Under high pressure (deep sea)
19. Differentiate between Respiratory and Metabolic acidosis and alkalosis with their
compensatory mechanisms in given set of Arterial Blood Gases and Electrolytes.
20. Explain how different factors produce hypoxia, hypercapnia and dyspnea.
21. Describe the rationale and types of Oxygen therapy.
22. Describe pulmonary circulation and pulmonary edema.
23. Describe the role of allergens and occupations in the manifestation of
respiratory diseases..
24. Appraise the preventive measures of the complications of common
occupational lung disease.
25. Describe the impact of ARI on the health status of community with special
emphasis in children under 5 years of age.
26. Describe the risk factors for ARI in children in a community setting.
27. Describe the general principles of the domiciliary management of ARI.
28. Describe the integrated management of childhood illness.
29. Describe priority health problems of children under 5 years of age in developing
countries with special reference to Pakistan.
30. Identify the structures on a normal chest X ray, C.T scan and models.
SKILLS
Identify on a given microscopic slide the various components of respiratory system.
Perform physical examination of respiratory system.
Perform and interpret
Peak expiratory flow volume.
Vital capacity.
Interpret ABGs on given reports.
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LEARNING STRATEGIES
S.NO.
1
2
TOPIC
Introduction to respiratory system
Development of respiratory system
a. Nose, paranasal sinuses
b. Pharynx, Larynx, Trachea
c. Bronchial tree, pleura, lungs
d. Diaphragm & body cavity
Histology of upper respiratory tract
3
4
5
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
6
7
Histology of lower respiratory tract
Gross anatomy of respiratory system
External features of nose, nasal septum & nasal
cavity, Nasopharynx
Lateral wall of nose and Paranasal air sinuses.
Larynx & Laryngopharynx : Skeleton, cartilages,
joints, ligaments & membrane.
Larynx: Cavity, muscles, neurovascular supply.
Trachea neurovascular supply and lymphatic
drainage
Thoracic wall, sternum & ribs, joints of the thoracic
cage, thoracic inlet & outlet
Intercostal spaces, musculature & accessory
muscles of respiration
Diaphragm
Mediastinum and its contents Lymphatics and
lymph nodes of thorax and thoracic duct
Pleura (layers, functions, nerve supply & surface
marking
Lungs: Surfaces, borders, fissure, lobes, roots
Bronchial tree, bronchopulmonary segments,
blood supply, nerve supply and lymphatic
drainage
Nerve supply, arterial supply and venous drainage
of the thoracic wall along with azygous system of
veins
Pharynx (Nasopharynx, Oropharynx and
Laryngopharynx)
Surface marking of pleura, lung and trachea
Pulmonary volumes & capacities
Compliance of lungs and work of breathing
STRATEGY
Lecture
PBL
HRS.
1
4
Lecture
Lecture
Lecture
Lecture
Lecture
Lecture
D/Ds
1
1
1
1
1
2
30
D/D
2
D/D
D/D
2
2
D/D
D/D
2
2
D/D
2
D/D
2
D/D
D/D
2
2
D/D
2
D/D
D/D
2
2
D/D
2
D/D
2
Skill
SGS
SGS
Lecture
2
2
2
1
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Ventilation & perfusion in lungs
ARDS/ NRDS
Etiology, pathogenesis, diagnostic workup, risk
factors, and preventive strategies of common
respiratory infections.(Pneumonia & TB)
Biochemical role of Vitamin D in asthma
Lecture
Lecture
PBL
1
1
4
Lecture
1
12
13
Pneumonia and Tuberculosis
Etiology, pathogenesis, diagnostic workup, risk
factors, treatment and preventive strategies of
obstructive lung diseases.
Lecture
PBL
Lecture
2
4
1
14
15
1
4
1
18
19
Pharmacology of drugs for Asthma
Lecture
Etiology, pathogenesis, diagnostic workup, risk
PBL
factors, and preventive strategies of restrictive
Lecture
lung diseases.
Respiratory tumors
Lecture
Respiratory System I
Kodachrom
e
Solutions (nutrient, hospital)
Practical
Risk factors and preventive strategies for Asthma
Lecture
20
Transport of O2 in blood
1
21
2
27
28
O2 – Hb dissociation curve: CO-Hb dissociation
SGS
curve
Transport of CO2 in blood: CO2-Hb dissociation
Lecture
curve
Control of respiration
Lectures
Respiratory adjustments during exercise
Lecture
Respiratory adjustments at low & high atmospheric
SGS
pressure
Hypoxia, hypercapnia and dyspnea
Interactive
Session
Pharmacology of the Antitussive and mucolytics
Lecture
Effects of hypo & hyperventilation on pH of blood
Lectures
29
Analysis of ABGs in acidosis & alkalosis
PBL
4
30
31
32
Mechanism of pulmonary circulation & edema
Rationale of O2 therapy in pulmonary diseases
Graphs in respiratory physiology
SGS
Lecture
Lecture
SGS
2
1
1
2
33
34
35
Formation and functions of surfactant.
Microscopic structure of respiratory system (lungs,
trachea)
Lecture
Practical
1
6
11
16
17
22
23
24
25
26
Lecture
1
2
2
1
1
2
1
2
1
1
2
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37
38
The common occupational lung diseases.
Lecture
Describe the preventive measures, natural history
and complications of occupational lung diseases
(Pneumoconioses).
Respiratory System II
Kodachrom
e
Drops calculations
Practical
Perform and interpret vital capacity
Practical
39
Study of chest radiographs & CT Scan
Lecture
1
40
Perform peak expiratory flow
Practical
2
41
Role of allergens and occupations in the
manifestation of respiratory diseases
Impact of ARI on the health status of different age
groups
Risk factors for ARI and general principles for
management of ARI in children under five years of
age
Management & home advice for ARI in children
under five years of age
Differentiate between life threatening & non life
threatening ARI.
Integrated management of childhood illness
Priority health problems of children under 5 years
of age in developing countries with special
reference to Pakistan.
Lecture
1
Lecture
1
PBL
4
Lecture
1
Video
2
PBL
Lecture
4
1
Diseases of nose,sinuses, nasopharynx. and larynx
Lecture
Total Hours
1
158
36
42
43
44
45
46
47
48
2
2
2
SGS = Small Group Session
PBL = Problem Based Learning
CBS = Case Based Session
D/D = Dissection & Demonstration
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COURSE NAME: INFERENTIAL BIOSTATISTICS
COURSE NO: 307
Objectives:
At the end of the term students should be able to:
1. Explain the concept of hypothesis testing.
2. Determine and interpret the confidence interval for population means and
Proportions.
3. Determine the sample size for a variable at a specified level of accuracy.
4. Explain the significance of:
i) p-value
ii) Power
iii) Types of error
5. Explain the procedure for applying the tests of significance on a given data set.
6. Apply the appropriate test of significance on a set of data:
i) z-test
ii) t-test (paired / pooled)
iii) Chi-square
iv) Test of proportions v) Correlation
vi) ANOVA
7. Identify the types of error in a test of significance.
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LEARNING STRATEGIES
Objective
No.
1,5 & 6 (i)
2,7 & 3
6 (ii)
6 (iv) & 2
6 (iii & v)
TOPIC
STRATEGY
HOURS
Sampling Distribution of means
Test of significance
Test for single mean
Confidence interval for population
mean
Types of error p-value
Sample Size
Pooled t-Test
Paired t-Test
Lecture
Small group session
3
3
Lecture
Small group session
3
3
Lecture
Small group session
2
3
Test of single proportion & test of
two proportions
Confidence interval for proportions
Chi-Square test
Correlation
Lecture
Small group session
3
3
Lecture
Small group session
2
3
Total Hours
28
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
COURSE NO: 211
COURSE: HAEMOPOETIC SYSTEM
Objectives:
1. Describe the composition, properties and functions of blood.
2. Describe the functions of following plasma proteins:
a. i) Albumin
ii) Globulin ( , , )
iii) Ceruloplasmin
b. iv) -Fetoprotein
v) Haptoglobin.
vi) Transferrin
c. vii) C reactive protein
3. Describe the site of origin and process of hemopoiesis with special reference to
RBCs, WBCs and platelets.
4. Describe the Gross structure of the components of lymphoid organs (lymph
node, tonsil, spleen and thymus).
5. Describe the Microscopic structure of the components of lymphoid organs
(lymph node, tonsil, spleen and thymus).
6. Describe the development of the components of lymphoid system.
7. Describe the production of lymph and pattern of lymph flow from lymphatic
capillaries to the venous system.
8. Identify on a given microscopic slide/illustration/laboratory data the various
components of hematopoietic system with particular reference to:
a. RBCs
b. Lymphocytes
c. Polymorphonuclear leukocytes (neutrophils)
d. Basophils
e. Eosinophils
f. Monocytes
g. Reticulocytes
h. Platelets
9. Describe the structure, synthesis, and degradation of hemoglobin.
10. Describe the role of various hormones, vitamins and cofactors in the formation of
RBC.
11. Interpret the cellular count in a given blood report with special reference to RBC,
TLC, DLC and platelets.
12. Describe the various blood group systems, with special reference to ABO and Rh
blood group systems.
13. Describe the complications of transfusion with particular reference to:
a. ABO mismatch
b. Rh incompatibility and hemolytic anemia of the newborn.
c. Transmission of infections
14. Describe the mechanism of hemostasis (intrinsic and extrinsic pathways) and
pathogenesis of thrombosis.
15. Describe the physiological mechanisms that promote the dissolution of a blood
clot.
16. Analyze the following on basis of signs and symptoms, genetic susceptibility and
clinical data:
a. Hypochromic microcytic
b. Normochromic microcytic
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
c. Normochromic normocytic
d. Macrocytic (megaloblastic)
e. Sickle cell disease
f. Thalassemia
g. Primary polycythemia.
h. Secondary polycythemia
i. Purpura
j. Hemophilia
k. Von Willebrand’s disease
17. Describe briefly the types, pathogenesis & clinical features of leukemia.
18. Describe briefly the types, pathogenesis & clinical features of lymphoma
(Hodgkin, Non Hodgkin).
19. Describe the drugs used for the treatment of anemia and other hemopoetic
disorders.
20. Describe the mechanism of action, clinical uses, adverse effects, common drugdrug interactions and contraindications of the following:
a. Antiplatelet drugs
b. Anticoagulant drugs
c. Thrombolytic drugs
Skills:
21. Perform estimation of hemoglobin concentration by cyanmethemoglobin
method.
22. Perform estimation of ESR by Westergren method.
23. Perform bleeding time and clotting time.
24. Prepare peripheral blood film (thick and thin).
25. Demonstrate the Hb-Electrophoresis
26. Identify the various parts and their uses of Langerdoff”s and Dales
.
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
LEARNING STRATEGIES
TOPIC
Composition, properties and functions of blood
Hemopoiesis
Gross and microscopic features of the components
of hemopoietic and lymphoid system
Development of the components of hemopoietic
and lymphoid system
Structure, synthesis and degradation of heme
Types of hemoglobin
Types of anemia & polycythemia and their treatment
ABO and Rh blood group systems and..
complications of transfusion and plasma expanders
Lymphatic flow
Plasma proteins
Extrinsic and Intrinsic clotting pathways.
Consequences of thrombosis
Classification of leukemia
Classification of lymphoma
Agents used in anemia and hemopoietic growth
factors
Coagulation disorders, antithrombotics,
thrombolytics
Anticoagulants, antiplatelets
Thrombolytics
Various types of emboli
Identify the blood cells in the slide
Estimation of hemoglobin concentration
Demonstration of Hb electrophoresis
Estimation of ESR by Westergren method
Bleeding time and clotting time
STRATEGY
CBS
CBS
Lecture
Practical
HRS.
1
1
2
10
Lecture
2
Lecture
CBS
PBL
CBS
Lecture
CBS
Lecture
CBS
Lecture
Lecture
Lecture
2
2
4
2
1
2
1
2
1
2
2
Lecture
1
PBL
4
Lecture
Lecture
CBS
Practical
Practical
Practical
Practical
Practical
Total
1
1
2
2
2
2
2
2
56
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
COURSE NO: 224
IMMUNE SYSTEM:
Objectives:
1. Describe following types of immunity:
a. Natural immunity
b. Acquired immunity,
c. Active immunity
d. Passive immunity.
2. Differentiate between antigen and hapten, and discuss antigen presentation at
different sites.
3. Describe the production, structure and functions of T cells.
4. Describe the production, structure and functions of B cells, plasma cells, and
antibodies (IgA, IgD, IgE, IgG, and IgM) in bone marrow.
5. Describe the functions of the cytokines (Interleukins, Tumor necrosis Factors,
Interferon Factor, Platelets Drive Growth Factor and Platelet Activating Factors).
6. Describe primary and secondary immune response (T, B & scavenger cells).
7. Describe the sequence of events in the development of cell-mediated and
humoral immune response following first and second exposures to antigens with
particular reference to BCG, Hepatitis B and polio vaccines.
8. Describe the role of vitamin D in immunity.
9. Describe the steps of complement pathways and its functions.
10. Define Isograft, Autograft, Allograft and Xenograft.
11. Describe histocompatibility antigens (HLA) and histocompatibility testing.
12. Describe the different types of hypersensitivity reactions.
13. Describe the mechanism involved in autoimmunity.
14. Describe the mechanism involved in immunodeficiency disorders.
15. Describe transplant rejection reactions and graft-versus-host disease.
16. Describe the role of inflammation in defense mechanisms of the body.
17. Describe the mechanism of vascular changes in acute inflammation.
18. Describe the following cellular events in acute inflammation:
a) Margination
b) Diapedesis
c) Chemotaxis
d) Opsonization
e) Pavementation
f) Degranulation
19. Describe the role of local and systemic mediators in acute inflammation.
20. Describe the role of cytokines in acute inflammation.
21. Describe the systemic effects of acute inflammation.
22. Describe the mechanism of chronic inflammation.
23. Describe the mechanism of chronic granulamatous inflammation.
24. Describe the mechanism of action, uses and adverse effects of ecosinoids.
25. Classify NSAIDS. Describe the mechanism of action, uses and adverse effects of
NSAIDS.
26. Describe the mechanism of action of Aspirin and paracetamol toxicity.
27. Describe the mechanism of action, uses and adverse effects of immunemodulating drugs.
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
LEARNING STRATEGIES
TOPIC
Natural and acquired immunity, active and passive
Immunity
Antigen presentation
Cell mediated immunity and humoral immunity
Primary and secondary immune response
Role of vitamin D in immunity
Autoimmunity
Hypersensitivity reactions
Complement pathway
Histocompatibility antigens
Transplant rejection
Immunodeficiency disorder
Overview of immune modulation drugs
Acute inflammation
Acute inflammation and anti-inflammatory drugs
Mediators of acute inflammation
Role of cytokines in acute inflammation
Exudate and transudate
Chronic inflammation
Systemic effects of inflammation
Eicosanoids
NSAIDs
Immune modulating and suppressing agents
Aspirin and Paracetamol toxicity
Langerdroff’s and Dale’s apparatus
Wound healing
Outcome of healing and repair
Morbidity and mortality due to immunizable diseases
Aims and objectives of EPI and criteria for inclusion of
specific vaccines
Schedule of EPI
Indications, contraindications and adverse reactions
of vaccines in EPI
Importance of cold chain for vaccines
Bleeding Disorders
STRATEGY
HRS.
CBS
2
Lecture
PBL
CBS
CBS
CBS
CBS
Lecture
Lecture
PBL
Lecture
Lecture
Lecture
PBL
Lecture
Lecture
CBS
Lecture
Lecture
Lecture
Lecture
Lecture
CBS
Practical
PBL
Lecture
Lecture
1
4
2
2
1
2
1
1
1
1
2
1
4
1
1
1
1
1
1
1
2
2
2
4
1
1
Lecture
1
Lecture
1
Lecture
2
Lecture
Lecture
Total
1
2
51
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
Learning Resources
Recommended Books
Anatomy
K.L. Moore. Clinically Oriented Anatomy, 6th edition 2009.
B Young, J.W. Heath. Wheater’s Functional Histology, 5th edition 2006.
Keith L. Moore. The Developing Human 9th edition 2011.
Medical Histology by Laiq Hussain 4th ediation 1999.
Richard S. Snell. Clinical Anatomy for Medical Students, 9th edition 2011.
Langman’s Medical Embryology 12th edition 2011.
Physiology
Arthur C. Guyton, John E. Hall. Textbook of Medical Physiology, 12th edition 2010.
Recommended
Robert M. Berne, Matthew N. Levy. Principle of Physiology, 5th edition 2006.
William F. Ganong. Review of Medical Physiology,24th edition 2012.
Sherwood, Lauralee. Human physiology : from cells to systems 8th edition 2012.
Bijlani, R.L. Understanding Medical physiology : a textbook of medical students
4th edition 2012.
Biochemistry
Robber K. Murray, Daryl K. Granner, Peter A. Mayes, Victor W. Rodwell. Harper’s
Biochemistry, 29th edition 2012.
Pamela C. Champe, Richard A. Harvey. Lippincott’s Illustrated Review of
Biochemistry, 5th edition 2010.
Harold C. Sox Jr. Common Diagnostic Tests, use and interpretation 2nd edition
1990.
Jhon F. Zilva, Peter R. Pannall, Philip D. Mayne. Clinical Chemistry in Diagnosis
and Treatment, 5th edition 1988.
U. Satyanarayana. Biochemistry 2006.
Community Health Sciences
Mohd. Ilyas et. Al. Community Medicine and Public Health, 7th edition 2006.
Kumza JW, Bohnenblust SE, Basic Statistics for the Health Sciences, 5th Edition
2005.
CHS Course Book (available from CHS / ZU).
Pharmalcology
Bertram G. Katzung. Basic and Clinical Pharmacology, 12th Edition. 2011.
Bennett and Brown. Clinical Pharmacology, 11th Edition. 2012.
27
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Ziauddin University
MBBS 1 Year 2013– 2014 Semester 2
Goodman and Gillman. The Pharmacological Basis of Therapeutics, 12th Edition.
2011.
Rang, Dale, Ritter and Moore. Pharmacology, 7th Edition. 2012.
Tripathi. Essentials of Medical Pharmacology. 6th Edition. 2008.
Pathology
Peter D. Turnpenny, Emery’s Elements of Medical Genetics (14th ed.). New York:
Churchill Livingstone. 2011.
Cotran RS, Kumar V and Collins T. Robbin’s Pathologic Basis of Disease (8th ed.).
Philadelphia: W.B. Saunders. 2012.
Walter JB and Talbot IC. Walter and Israel’s General Pathology (7th ed.). New
York: Churchill Livingstone. 1996.
Kumar V, Cotran RS, and Robbins SL. Basic Pathology (9th ed.). Philadelphia: W.B.
Saunders. 2012.
Rubin E, Pathology (6th ed.) Philadelphia: Lippincott-Raven. 2011
Ivan Roitt. Riott’s Essential Immunology (12th ed.). New Delhi:I.K. International Pvt.
Ltd. 2011.
Wheater P et al. Basic Histopathology: A Color Atlas and Text (4th ed.).
Edinburgh: Churchill Livingstone. 2002.
Computer Assisted Learning:
Topic
-
Catalogue #
Interactive Atlas of Human Anatomy
Explorations in Cell Biology and Genetics
Interactive Physiology
Wheater’s Interactive Histology
Radiological Anatomy
Imaging Atlas of Human Anatomy 2.0
Human Anatomy
Virtual Human Atlas
Comprehensive Microscopic Anatomy
Video:
Statistics. Decisions through Data.
43 and 116
44 and 115
48
52
54
67
76
78
77
12-16
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Ziauddin University
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STUDENT CODE OF CONDUCT
1.
1.1
1.2
1.3
2.
2.1
INTRODUCTION:
The ZU was established with the objective of developing human resources
appropriately equipped to deal with the problems, which are of particular
relevance to its environment. The University considers its students to be mature
and responsible individuals and makes all efforts for developing matching
professional attributes.
The University expects that behaviour of the students, within and outside the
premises of the University, should be in conformity with the highest standards of
honesty, morality and discipline. The students should respect the rights and
privileges of the members of the University community at all times. They should
refrain from conduct that might damage the reputation of the University or any
of its programmes.
The students should refrain from any conduct that may lead to the disruption of
an academic programme of the University and from cheating and plagiarism in
any setting of the University.
THE CONDUCT OF STUDENTS:
GENERAL CONDUCT:
All students should present themselves with dignity befitting their status as mature
professionals and responsible citizens.
a.
Students in all settings on campus are expected to dress in a simple and
decent manner.
b.
Students individually or as a group, should obtain written ZU approval
before organizing or assisting in organizing demonstrations, rallies or
picketing on campus.
c.
Students individually or as a group should refrain from disseminating or
causing to disseminate material or engage in activity which hinder or
prevent the full participation of another person or group in the life of the
University.
d.
Religious and social activities held on campus must have prior written
University authorization.
e.
Students should ensure that their actions do not endanger or threaten the
health, safety or well being of other persons.
f.
Students should refrain from any behaviour, which can be interpreted by
others as sexual harassment.
g.
Students should obtain written authorization before making public
statements, communication, or correspondence with the press or other
media for mass communication on behalf of the University.
h.
Unless otherwise authorized in writing the students should refrain from
inviting government and or foreign dignitaries, ministers, representatives of
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Ziauddin University
I.
2.2
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MBBS 1 Year 2013– 2014 Semester 2
foreign governments/agencies or other public personalities in their official
capacity on campus.
Students should refrain from any activity, which is subversive of discipline
and may constitute misconduct.
ACADEMIC CONDUCT:
All students should diligently apply themselves to their registered courses of
study. They should respect the confidentiality of information and should use it in
no other circumstances than for professional and authorized academic
purposes.
a.
Students should attend lectures, PBLs, tutorials, seminars, practicals, clinics
and ward assignments, examinations and other scheduled courses,
activities and assignments given by the faculty except for reasons
acceptable to the University.
b.
Students should ensure that any original academic writing, including
essays, theses, research projects or assignments in a course or programme
of study either represents their own words, ideas, images or data or is
appropriately referenced.
c.
Students should obtain authorization before procuring, possessing,
distributing or receiving any confidential material pertaining to academic
tests, examinations, research or laboratory results from any source.
d.
Students should respect the confidentiality of information pertaining to
patients, including their records or files.
RULES:
1. INTRODUCTION:
1.1
Students of ZU are required to exhibit good attitude and discipline. Guidelines
have been delineated in the University’s Code of Conduct (“Code of
Conduct”) framed by the University to provide students with a reference to
the standards for discipline. It is expected that all students will strictly uphold
and adhere to the Code of Conduct, but in cases where there are grounds
to suspect a breach or any infringement of the Code of Conduct or
disregard or contempt of the Code of Conduct, disciplinary action may be
initiated for such behaviour committed either within or outside the precincts
of the University or any establishment, project or setting thereof anywhere
located. The reference to the expression “University” shall mean and include
(unless the context provides otherwise), any establishment, project or setting
of the University located anywhere in the world.
1.2
The disciplinary procedure to be followed upon breach and /or infringement
of the Code of Conduct is defined herein, along with the actions, which
constitute disciplinary offences and the decision-making authority.
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
2. DISCIPLINARY OFFENCE:
Without prejudice to the generality of the provisions of the Code of Conduct
and the provisions of Rules 1.1 and 1.2, the following conduct will constitute
disciplinary offence:
1.1.
MINOR OFFENCES:
a. Repeated failure to conform to scheduled instruction, practical work,
examination, clinical assignments and or forcing other students to act
likewise.
b. Smoking, eating and drinking are prohibited in the University Premises.
NOTE: All minor offences will be dealt with as major if repeated.
1.2.
a.
b.
c.
d.
e.
f.
g.
h.
i.
MAJOR OFFENCES:
Assault on students, members of staff, faculty or patients.
Any form of unauthorized picketing, rallies, demonstrations or organized
obstructions of any student/University/University Hospital function in any
manner whatsoever.
Any attempt to conceive, design or affect any plans of whatever nature
whose object or consequence is to disrupt academic programmes of the
University or its operations.
Malicious acts, theft, willful damage or misuse of University property.
Disorderly conduct and/or molestation of other members of the University
Community within and outside the University premises.
Bringing unauthorized persons in the university premises or any other
building related to the University.
Cheating, plagiarism and or use of unfair means in examinations or any
other academic setting.
Possession, use and display of firearms, drugs, alcohol or other contraband
items on campus or at University related events.
Any other offence, which is considered to be harmful to the academic
atmosphere.
DISCIPLINARY ACTIONS:
The University will have the powers to impose any one or more of the following
actions. However, nothing will preclude the University from requiring any student
or parent or both to execute any bond, assurance or undertaking to support
expected conduct throughout his/her stay at the University.
MINOR DISCIPLINARY OFFENCE will be liable to one or more of the following
sanctions.
a) Counselling of the student.
b) Probation: A student can be put on probation for a specified period of time
with mandatory periodic counseling.
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
c) A letter of warning or reprimand to the student with information to the
parents.
d) The payment of fine by the offender commensurate with the nature and
gravity of the offence committed amounting up to 5% of the annual fees of
the student.
MAJOR DISCIPLINARY OFFENCE will be liable to one or more of the following
sanctions
a) The payment of fine by the offender commensurate with the nature and
gravity of
the offence committed amounting up to 5% of the annual
fees of the student.
b) Suspension from the University for a specified period.
c) Expulsion from the University.
d) Any other penalty which the University may deem fit to impose.
DISCIPLINARY PROCEDURE:
The following steps constitute the disciplinary procedure.
4.1
Any disciplinary offence not of serious nature may be brought to the attention of
the offender by an affected student through the faculty/staff member
concerned of the University. The purpose of this in the first instance is to resolve
the matter through constructive criticism ounseling and/or admonition. The
expression “offence not of serious nature” appearing herein above shall be such
offence as is considered as an offence of not a serious nature by the
faculty/staff member of the University in his/her sole discretion. The expression
“faculty/staff member of the University” shall be in relation to the following Units
of the University namely,
(i) Medical College, (ii) College of Nursing, (iii) College of Physical Therapy
(iv) School Medical Technology (v) College of Pharmacy. (vi) College of Speech
Language Therapy (vii) Dental college (viii) Faculty of Media Sciences.
4.2
If the matter is not resolved or the student repeats an offence or if the offence is
a serious one, the head of the Unit concerned i.e. (i) in the case of Medical
College/College of Pharmacy – the Dean, (ii) in the case of school of Medical &
CSLT Technology – the Director and (iii) in the case of school of Physiotherapy /
School of Nursing respective dean/Principals or their designate will be informed,
who shall advise investigation by the Disciplinary Committee constituted under
Rule 5.1. The outcome of the investigation shall be communicated to the head
of the relevant Unit. He/she may act upon the recommendation of the
Disciplinary Committee or in accordance with his/her judgment. The decision
shall then be communicated to the offender. The matter shall be resolved
normally within fourteen working days of the day the Head of the Unit is informed
of the offence.
4.3
A student may appeal in writing against such a decision to the Head of his Unit
within ten working days of the decision having been communicated in writing to
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Ziauddin University
4.4
4.5
5.
5.1
5.2
5.3
6.
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MBBS 1 Year 2013– 2014 Semester 2
the student. The student shall within the said period of time submit his/her appeal
to the Head of his/her Unit i.e. Dean or his designate in the case of Medical
College and College of Pharmacy, Dental College, College of Nursing– (ii) in the
case of Institute of Medical Technology the Director and (iii) in the case of
College of Physical Therapy Principal as the case may be for onward submission
to the Vice Chancellor. The Head of the Unit shall request the Vice chancellor to
constitute the Appeal Committee under Rule 5.2 and refer the matter to it for
consideration of the appeal.
The Appeal Committee shall take up and review the case and communicate its
decision in writing to the VC normally within ten working days. The VC may act
upon the recommendations of the Appeal Committee or in accordance with
his/her own judgment.
If the decision is not acceptable to the student, he/she may request a final
review by the VC. The VC’s decision thereafter shall be final and binding.
STRUCTURE OF THE DISCIPLINARY AND APPEAL COMMITTEES:
The structure of Disciplinary Committee shall consist of five members of the
faculty, one of whom shall be the Chairperson. The Chairperson and members
may serve for three years. They may be appointed for another term of two
years. The Committee shall be appointed by the ZU Academic Council.
A University Appellate Committee shall be appointed as and when required, by
the VC. It shall consist of three faculty members (one of whom shall be the
chairperson) who have not been associated with
ounseling or with
investigation of the student’s current or his/her any previous offence.
The Disciplinary Committee and the Appellate Committee will have authority to
call for evidence or questioning any person witness to the offence/ event
reported for investigation to the disciplinary committee.
DISCIPLINARY AUTHORITY:
Notwithstanding anything contained herein, the VC shall be the final disciplinary
authority of the University with powers to:
Appoint or change a Disciplinary Committee and define disciplinary
procedures.
a. Suspend the privileges of enrolment of a student who is suspected of a
breach of the code, pending investigation.
b. Act upon the recommendations of the Disciplinary Committee which may
include expulsion of a student from the University.
c. Appoint an Appeal Committee and define procedures for appeal.
d. Take any measure that may be necessary for ensuring effective disciplinary
procedures.
e. Delegate any of his authority.
f. Make, alter and modify the Disciplinary Procedure (Rules).
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
DEFINITIONS:
The said expression shall mean and include any person enrolled with the University for a
course of studies leading to an undergraduate or postgraduate degree or diploma or
certificate within the University or the University Hospital or any person registered with
any other University or Institution who has been accepted for an approved programme
of study or training at ZU.
Vice Chancellor:
The VC shall be deemed to mean the VC of the University unless otherwise stated.
Dean:
Unless otherwise indicated, the “Dean” shall be interpreted as the Dean of
(a) Medical College.
(b) Post Graduate Studies. (Clinical / Basic)
(c) Pharmacy.
(d) College of Nursing
Unit:
Unless otherwise indicated, a unit shall mean the Medical College, College of Physical
Therapy, College of Pharmacy or any Institute, College or School of the University.
Head of the Unit:
Shall mean Director of the Medical Technology & College of SLT, Principle of College
of Physiotherapy and Dental College, Dean or his/her designate for the Medical
College, Pharmacy.
Suspension:
Suspension requires a student to withdraw completely from all the activities of the
University for a specified period of time. Upon expiry of the period of suspension the
student will be re-admitted, contingent upon the terms and conditions of the
suspension without any obligation or liability whatsoever on the part of the University or
any of its staff/faculty members or officers.
Expulsion:
Expulsion means termination of enrolment in the University.
Interns and Residents:
These shall be deemed to be the students of the University.
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Ziauddin University
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MBBS 1 Year 2013– 2014 Semester 2
Fine:
This is an order to student for payment of a sum of money to the University as penalty
for any offence committed by the student. The student may or may not be permitted
to continue with the course of studies until the fine has been paid.
END
35