ZIAUDDIN MEDICAL UNIVERSITY
Transcription
ZIAUDDIN MEDICAL UNIVERSITY
4 ISSUED BY: REGISTRARS OFFICE, MAY 2014 FIRST YEAR SEMESTER 2 |MAY 2014 - SEPTEMBER 2014| CONTENTS S. No. Page 1. Introduction 2 2. Learning Methods 3 3. Examination Rules 7 4. Test Administration Rules & Regulations 11 5. Whom to Contact 13 6. Management 14 7. Course Objectives & Strategies Module – 1 Respiratory System 15 Module – 2 Inferential Biostatistics 20 Module – 3a Haemopoietic System Module – 3b Immune System 22 25 8. Learning Resources 27 9. Student Code of Conduct 29 10. Schedule 36 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 INTRODUCTION Why Study Guide? To inform students how student-learning programme has been organized semester wise, and how it would be implemented. To help students organize and manage their studies throughout the year. What is a Study Guide Book ? (Figure selected from AMEE Medical Education Guide #16) The Guide provides: Information on organization and management of the semester. This will help you to contact the right individual in case you have any difficulty. A description of the module objectives which you will be expected to achieve at the end of each module. Information on learning methods that you will experience during the module. The methods include: Problem-Based Learning (PBL), tutorials (SG), lectures, skills/ practicals and field visits. These learning methods should help you achieve the module objectives. A description of the learning resources available for the Semesters. These include: books, Computer Assisted Learning Programmes, videos and others. Information on the contribution of continuous and semester examinations and your overall performance. Information on the methods of assessment that will be held to determine your achievement of objectives. Information on examination policy, rules and regulations. The Curriculum: It is integrated comprising of system based modules Curriculum Organization : Consists of following for each module and generic courses Course No Duration of Semester and Modules Objectives of each module Learning Strategies Number of Hours 2 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 Test Schedule / CAT & Semester. Semester Schedule. LEARNING METHODS The following teaching / learning methods/strategies are used to promote better understanding: Problem Based Learning (PBL) Tutorials -Field Visits -Lectures Hospital Visits -Seminars Practicals -Assignments Computer Assisted Learning Program (CALP) Case- Based Sessions (CBS) Small Group Sessions (SGS) The programme emphasis is on: Problem-Based Learning: This is a small group activity in which the discussion revolves around a real life problem using the Seven Jump process. Students are expected to consult various learning resources to develop better understanding of the subject. Self-Directed Study: Students may achieve the Objectives by assuming responsibilities of their own learning. How? By sharing and discussing with peers, working individually, seeking information from LRC, teachers and resource persons within and outside the college. This is possible by utilizing scheduled self -study period in college, and time outside the college. Community-Based Learning Activities: This takes place within a community including homes of individuals, families, and a variety of health service settings. Family assignment is an integral component of this activity. The Department of Family Medicine monitors students’ activity, and provide constructive feedback. PROBLEM-BASED LEARNING (PBL): WHAT IS IT? It is a method of learning in which learners (students) in small groups first encounter a problem, which are close to real life situations. The problem is generally discussed in two sessions. First Session: Learners in small groups, using existing knowledge, discuss (in the presence of a tutor) and list what they do not know or are not sure of, about the problem. The list is known as learning issues (goals). 3 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 Self Study: Learners have approximately three days time to report. During this time, learners search for new information required to achieve the learning goals listed. In this process, learners are encouraged to consult various learning resources in addition to the textbooks. This does not require a tutor. Second Session: Learners discuss learning issues and application of new knowledge to the problem and summarize by integrating prior and new knowledge in understanding the problem. 4 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 EXAMPLE OF PBL SCENARIO: A 1½ year old male was brought to the OPD by his father with complaints of a swelling in the right groin since birth. Birth History: He was born at 34 weeks’ gestation. His birth weight was 2 kg. PHYSICAL EXAMINATION: BP: 100/60mmHg Pulse: 86/min Temp: 98oF R/R: 15/min Local Examination: Left testis is palpable in the scrotum. Right testis could not be palpated in the scrotum. A 1x1 inch oval, firm, non-tender mass was present in the right inguinal region. Lab: Serum testosterone level: 110 ng/dl Ultrasound: Showed an ovoid homogenous medium-level echogenicity within the right inguinal canal. The parent was counseled about the prevalence of the condition. Orchidopexy was advised. 5 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 PBL PROCESS JUMP 1 Read the Problem: Clarify terms not known to you in the problem description The JUMP 2 Define the problem. Draw up a list of phenomena that need to be explained Seven Jumps JUMP 3 Explain the problem Try to produce as many different explanations for the phenomena as you can think of JUMP 4 Arrange the explanations Proposed in a logical sequence and summarize them JUMP 5 Formulate learning goals: make a list of what you need to study in order to solve the problem JUMP 6 Through individual study, attempt to fill the gaps in your knowledge JUMP 7 Summarize the information collected and verify it by applying it to the problem Evaluation 6 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 EXAMINATION RULES In one academic year there will be two semesters each followed by an examination. At the end of the academic year there will be resit examinations for 1st and 2nd semester courses. A student passing in 1st semester will be allowed to go to 2nd semester. Those failing in courses of 1st semester will also be allowed to join 2nd semester classes but will appear in the resit exam for the required courses held at the end of the academic year. Students failing in the 2nd semester will also appear in the resit exam at the end of the year. Students failing to achieve required aggregate after the resit of 1st or 2nd semester courses / subjects will repeat the year. There will be external examiners in all semester examinations and resits. 2. ASSESSMENT: MOST FREQUENTLY ASKED QUESTIONS (i) CONTINUOUS ASSESSMENT Q. Are tests scheduled throughout both semesters? YES Q. What contribute to continuous assessment in Semesters I and II? Scheduled test/s for every module during the semester PBL, assignments, presentations (may not necessarily be all) Q. In tests and semester examinations, what methods are used to assess knowledge and skills? MCQs: One best/ true false. Structured cased based viva voice Practicals and Objective Structured Practical Examinations (OSPE) Q. What is the passing mark or score for tests and semester examinations? Fifty-five percent (55%). Q. What is the grading system? Satisfactory (S) 60% and above Satisfactory Borderline (S*) 55 to 59% Unsatisfactory Borderline (US*) 50-54% Unsatisfactory (US) Below 50% Q. Are the students notified of the marks in tests and semester examinations and receive feedback of their progress? Marks are not notified but Results are notified in semesters of S, S*, US, or US* Students receive feedback on written tests of MCQs. Q. How is the result compiled of Semesters One and Two? According to duration, and importance, every module may have one to three tests which carry a defined weightage. Test marks are totaled according to the weightage. 7 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 The following EXAMPLE may help you understand how Continuous Assessment result is compiled. Weightage for Continuous Assessment (Sample) Test PBL Total 75% 25% 100% Note: Quizzes etc may be scheduled by individual module Coordinator, which may not contribute towards your aggregate score. Q. Is there a final or annual examination? No There are two semester examinations for 1st year MBBS – Semester I & II. Q. Are all enrolled students eligible to take the Semester examination? No Eligibility is determined as follows: Attendance Cont. Assess. 1 Decision Eligible for Semester 2 75-80% Eligible for Semester 3 60 – 75% Eligible for Re-sit 4 <60% Any score Repeats the year* 5 Any value <35% Repeats the year* *Note: To decide about repeating the year cumulative scores for two semesters is considered(Attendance and Continuous Assessment) Q.Does continuous assessment has any credit or contributes towards the Semester Examination? Yes (20%). Q. Who is declared Satisfactory? Student is declared Pass if, o He/she scores an aggregate of 55% cumulative in each semester. AND o Scores a minimum of 50% in each subject. Note: If student score an aggregate of 55% in the two semesters, but in any individual subject scores <50%, then cumulative score of that subject in both semesters will be considered to declare him satisfactory. 8 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 Q. What happens if a student is unable to sit for the Semester Examination? He/she is allowed to take the resit examination which will be considered as second chance. Q .What happens if a student is unable to sit for the Resit Examination? The student will be allowed to repeat the year provided he/she has cleared at least one semester for that year. If the student has not cleared both the semester and the resits he/she will be asked to withdraw. WITHDRAWAL FROM THE PROGRAM A student of first and second year will have to withdraw from the program if he/she fails to pass both semester examinations of any year, within 2 years (4 attempts) TEST ADMINISTRATION RULES and REGULATIONS GENERAL RULES: All tests /examinations are monitored by the Department of Examination with the support of the College Dean/Principal, faculty and staff. To ensure that the examinations are held according to the standard conditions and that no examinee or group of examinees receives unfair advantage in the examination, Students (examinees) must strictly adhere to / abide by the rules and regulations of the University. IRREGULAR BEHAVIOR Specific examples of irregular behavior include, but are not necessarily limited to the following: 1. Copying answers from another examinee or allowing answers to be copied. 2. Making notes of any kind during an examination. 3. Failure to follow instructions of the staff present in the examination hall. 4. Acts of disruptive behavior such as raising ones voice, talking to others, interrupting the examination process upon entering the examination hall, or during an examination and other similar acts of behavior. 5. During an examination usage of any unauthorized material such as photographic equipment, communication or recording devices, including electronic paging devices and cellular telephones. 9 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 6. Altering or misrepresenting examination result, theft or unauthorized possession of examination materials. 7. Memorizing and reproducing examination materials and any unauthorized reproduction by any means and / or dissemination of examination materials. 8. Looking in the direction of another examinee, passing of written notes, leaving written notes on vacant seats/ desks not occupied by examinees during the examination may be considered as evidence of copying or attempting to copy and a report of such behavior may result in irregular behavior. 9. Sitting for an examination without being eligible for it, impersonating an examinee or engaging a proxy to take the examination. 10 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 TEST ADMINISTRATION RULES AND REGULATIONS Advice for Students: What to do? Students should arrive at the examination hall before scheduled time. Students arriving within 10 minutes after scheduled test time may be admitted only by the approval of head examiner or official of the Department of Examination. Incase a student arrives late, that is, after scheduled time, he / she is not to be admitted. 2. Students should present College Identity Card and Admit Card for Annual / Resit Examinations. If student/s does not bring the required Identification Card, he / she may not be admitted to the examination. 1. Advice for Students: What NOT to do? 1. Do not bring into the examination hall any personal belongings, including mechanical or electrical devices, backpacks, handbags, books, notes or study guide materials, calculators, digital watches, watches with computer communication and/ or memory capability, electronic paging devices, recording or filming devices, radios, cellular telephones, food and drinks. Only for specified subject/s special instruction will be given on use of calculator for examination. Do not make written notes or record in anyway the contents of an examination. 3. Any notes found will be confiscated and reported for disciplinary action. 2. Do not communicate with, seek aid from, or provide aid to any other examinee during the examination. 5. Once you (students) start taking an examination, you cannot cancel that examination. 4. 6. If the test is completed in less than the time allotted then do not leave without seeking permission from the staff present in the examination hall. No extra time will be allowed if he /she leave the examination hall for any reason. 11 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 WARNING ` STUDENTS (EXAMINEES) OBSERVED IN ACT/S THAT IS/ARE POSSIBLE VIOLATION OF TEST ADMINISTRATION RULES OR OTHER FORMS OF IRREGULAR BEHAVIOR DURING AN EXAMINATION WILL BE REPORTED TO THE DISCIPLINARY COMMITTEE FOR ACTION. ALL STUDENTS FOUND INVOLVED IN INDISCIPLINARY ACTION IN THE UNIVERSITY PREMISES (INCLUDING SMOKING) WILL BE SUBJECTED TO DISCIPLINARY ACTION WHICH MAY BE IN FORM OF DEDUCTION IN ATTENDANCE FIVE CONSECUTIVE ACADEMIC SESSIONS. DRESS CODE: o WEARING WHITE COAT IS MANDATORY IN ALL CLINICAL AND LAB SESSIONS. o DRESS SHOULD BE DECENT AND FORMAL FOR BOTH BOYS & GIRLS. o SLIPPERS ARE NOT ALLOWED. 12 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 WHOM TO CONTACT? Any queries or difficulties with the schedule, learning strategy should be directed: In the first instance to the individual, teacher or module coordinator and then to Semester In-charge. Contacts: Semester Incharge Dr. Zil-e-Rubab Dean Ziauddin Medical College Dr. Kamran Hameed Controller of Examinations Dr. Owais Ismail Registrar: Mr. Mohammad Yousuf ZU Literary and Cultural Society Dr. Saeeda Baig 13 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 MANAGEMENT/ ORGANIZATION Semester Incharge: Dr. Zil-e-Rubab Professor, Department of Biochemistry Course Name Coordinator Respiratory System Dr Iffat Raza Inferential Biostatistics Dr Nosheen Zehra Haemopoietic & Immume System Dr. Fauzia Perveen Other Team Members Dr. Fouzia Shaikh Ms. Areeba Qamar Dr. Sofia Amjad Dr. Sameena Mohiuddin Dr. Shehla Shaheen Dr. Santosh Kumar Dr. Arsalan Manzoor Dr. Saniya Farrukh Dr. Najia Tabassum Dr. Madiha Sadiq Dr. Bilal Aheed Dr. Nazia Moin Mr. M. Haris Lucky Dr. Fatima Ali Raza Mughal Dr. Ghazala Farrukh Dr. Irrum Faisal ( E ) Dr. Maria Mohiuddin Dr. Ali Nawaz Bijrani ( E ) Dr. Sabeen Akbar Yezdani (E) Resource Persons: Basic Health Sciences: Anatomy Prof. Ishrat Shokh Prof. Nuzhat Hassan Dr Bushra Waseem Dr Kevin Borges Dr Arsalan Manzoor Biochemistry Prof. Saeeda Baig Prof. Zil-e-Rubab Dr. Shamim Physiology Prof. Syed Touseef Ahmed Dr. Sadaf Fatima Dr. Sofia Amjad Pathology Pharmacology Prof. Serajuddaula Syed Prof. Qamar Jamal Prof. Naila Hadi Dr. Fouzia Shiekh Dr. Faraz Baig Dr. Najia Prof. Zahida Memon Prof.Samia Pervaiz Prof. Owais Ismail Dr. Shehla Shaheen Community Health Sciences: Prof.Shahida Rasheed Dr. Farah Ahmad Dr. Nosheen Zehra Dr. Hassan Danish 14 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 COURSE NO: 212 COURSE: RESPIRATORY SYSTEM Objectives: At the end of the course students should be able to: 1. Describe the microscopic structure of Respiratory Tract and Respiratory Membrane on slides. 2. Explain the gross structure, neurovascular supply, lymphatic drainage and functions of: - Upper Respiratory Tract a. Nose - Paranasal Sinuses b. Pharynx - Larynx - Trachea - Lower Respiratory Tract a. Bronchial Tree b. Lungs c. Pleura 3. Describe the development, gross structure, neurovascular supply and functions of diaphragm. 4. Describe the development of respiratory system and the underlying developmental mechanism of the following: a. Tracheoesophageal fistula b. Respiratory distress syndrome (of newborn) 5. Describe the formation and functions of surfactant. 6. Describe the etiology, pathogenesis and natural history of the disease of respiratory distress syndrome. 7. Relate the diffusion of gases and mechanism of pulmonary ventilation to the structure of the lung and thoracic cage, with specific reference to work of breathing and compliance of lungs. 8. Differentiate between normal and abnormal pulmonary volume, capacity and pulmonary function tests in a given set of data. 9. Interpret normal and abnormal in a given set of different values of the partial pressure of respiratory gases. 10. Differentiate between normal and abnormal in a given set of ventilation perfusion ratio curves. 11. Analyze the cases of following diseases with reference to etiology, pathogenesis, diagnostic workup, risk factors, and preventive strategies. a. Restrictive lung diseases b. Obstructive lung diseases c. Common Respiratory tract infections d. Tumors of lungs and pleura. e. ARDS / NRDS f. Pneumonia g. Pulmonary Tuberculosis h. Diseases of nose,sinuses, nasopharynx. and larynx. 15 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 12. Classify the drugs used for the treatment and prophylaxis of asthma according to their mechanism of action. 13. Describe their adverse effects, contraindications and common drug –drug interaction. 14. Describe the mechanism of action and adverse effects of antitussives and mucolytic agents. 15. Explain the mechanism of transportation of oxygen and carbon dioxide in blood. 16. Correlate the factors involved in the production of abnormal curve in a given set of oxygen hemoglobin dissociation curves. 17. Explain Carbon dioxide and Carbon monoxide - Hb dissociation curve on the basis of its effects on binding of oxygen with hemoglobin. 18. Describe the mechanism of regulation of respiration (neural and chemical) on the following conditions: a. Exercise b. High altitude c. Under high pressure (deep sea) 19. Differentiate between Respiratory and Metabolic acidosis and alkalosis with their compensatory mechanisms in given set of Arterial Blood Gases and Electrolytes. 20. Explain how different factors produce hypoxia, hypercapnia and dyspnea. 21. Describe the rationale and types of Oxygen therapy. 22. Describe pulmonary circulation and pulmonary edema. 23. Describe the role of allergens and occupations in the manifestation of respiratory diseases.. 24. Appraise the preventive measures of the complications of common occupational lung disease. 25. Describe the impact of ARI on the health status of community with special emphasis in children under 5 years of age. 26. Describe the risk factors for ARI in children in a community setting. 27. Describe the general principles of the domiciliary management of ARI. 28. Describe the integrated management of childhood illness. 29. Describe priority health problems of children under 5 years of age in developing countries with special reference to Pakistan. 30. Identify the structures on a normal chest X ray, C.T scan and models. SKILLS Identify on a given microscopic slide the various components of respiratory system. Perform physical examination of respiratory system. Perform and interpret Peak expiratory flow volume. Vital capacity. Interpret ABGs on given reports. 16 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 LEARNING STRATEGIES S.NO. 1 2 TOPIC Introduction to respiratory system Development of respiratory system a. Nose, paranasal sinuses b. Pharynx, Larynx, Trachea c. Bronchial tree, pleura, lungs d. Diaphragm & body cavity Histology of upper respiratory tract 3 4 5 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) 15) 6 7 Histology of lower respiratory tract Gross anatomy of respiratory system External features of nose, nasal septum & nasal cavity, Nasopharynx Lateral wall of nose and Paranasal air sinuses. Larynx & Laryngopharynx : Skeleton, cartilages, joints, ligaments & membrane. Larynx: Cavity, muscles, neurovascular supply. Trachea neurovascular supply and lymphatic drainage Thoracic wall, sternum & ribs, joints of the thoracic cage, thoracic inlet & outlet Intercostal spaces, musculature & accessory muscles of respiration Diaphragm Mediastinum and its contents Lymphatics and lymph nodes of thorax and thoracic duct Pleura (layers, functions, nerve supply & surface marking Lungs: Surfaces, borders, fissure, lobes, roots Bronchial tree, bronchopulmonary segments, blood supply, nerve supply and lymphatic drainage Nerve supply, arterial supply and venous drainage of the thoracic wall along with azygous system of veins Pharynx (Nasopharynx, Oropharynx and Laryngopharynx) Surface marking of pleura, lung and trachea Pulmonary volumes & capacities Compliance of lungs and work of breathing STRATEGY Lecture PBL HRS. 1 4 Lecture Lecture Lecture Lecture Lecture Lecture D/Ds 1 1 1 1 1 2 30 D/D 2 D/D D/D 2 2 D/D D/D 2 2 D/D 2 D/D 2 D/D D/D 2 2 D/D 2 D/D D/D 2 2 D/D 2 D/D 2 Skill SGS SGS Lecture 2 2 2 1 17 Ziauddin University 8 9 10 st MBBS 1 Year 2013– 2014 Semester 2 Ventilation & perfusion in lungs ARDS/ NRDS Etiology, pathogenesis, diagnostic workup, risk factors, and preventive strategies of common respiratory infections.(Pneumonia & TB) Biochemical role of Vitamin D in asthma Lecture Lecture PBL 1 1 4 Lecture 1 12 13 Pneumonia and Tuberculosis Etiology, pathogenesis, diagnostic workup, risk factors, treatment and preventive strategies of obstructive lung diseases. Lecture PBL Lecture 2 4 1 14 15 1 4 1 18 19 Pharmacology of drugs for Asthma Lecture Etiology, pathogenesis, diagnostic workup, risk PBL factors, and preventive strategies of restrictive Lecture lung diseases. Respiratory tumors Lecture Respiratory System I Kodachrom e Solutions (nutrient, hospital) Practical Risk factors and preventive strategies for Asthma Lecture 20 Transport of O2 in blood 1 21 2 27 28 O2 – Hb dissociation curve: CO-Hb dissociation SGS curve Transport of CO2 in blood: CO2-Hb dissociation Lecture curve Control of respiration Lectures Respiratory adjustments during exercise Lecture Respiratory adjustments at low & high atmospheric SGS pressure Hypoxia, hypercapnia and dyspnea Interactive Session Pharmacology of the Antitussive and mucolytics Lecture Effects of hypo & hyperventilation on pH of blood Lectures 29 Analysis of ABGs in acidosis & alkalosis PBL 4 30 31 32 Mechanism of pulmonary circulation & edema Rationale of O2 therapy in pulmonary diseases Graphs in respiratory physiology SGS Lecture Lecture SGS 2 1 1 2 33 34 35 Formation and functions of surfactant. Microscopic structure of respiratory system (lungs, trachea) Lecture Practical 1 6 11 16 17 22 23 24 25 26 Lecture 1 2 2 1 1 2 1 2 1 1 2 18 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 1 37 38 The common occupational lung diseases. Lecture Describe the preventive measures, natural history and complications of occupational lung diseases (Pneumoconioses). Respiratory System II Kodachrom e Drops calculations Practical Perform and interpret vital capacity Practical 39 Study of chest radiographs & CT Scan Lecture 1 40 Perform peak expiratory flow Practical 2 41 Role of allergens and occupations in the manifestation of respiratory diseases Impact of ARI on the health status of different age groups Risk factors for ARI and general principles for management of ARI in children under five years of age Management & home advice for ARI in children under five years of age Differentiate between life threatening & non life threatening ARI. Integrated management of childhood illness Priority health problems of children under 5 years of age in developing countries with special reference to Pakistan. Lecture 1 Lecture 1 PBL 4 Lecture 1 Video 2 PBL Lecture 4 1 Diseases of nose,sinuses, nasopharynx. and larynx Lecture Total Hours 1 158 36 42 43 44 45 46 47 48 2 2 2 SGS = Small Group Session PBL = Problem Based Learning CBS = Case Based Session D/D = Dissection & Demonstration 19 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 COURSE NAME: INFERENTIAL BIOSTATISTICS COURSE NO: 307 Objectives: At the end of the term students should be able to: 1. Explain the concept of hypothesis testing. 2. Determine and interpret the confidence interval for population means and Proportions. 3. Determine the sample size for a variable at a specified level of accuracy. 4. Explain the significance of: i) p-value ii) Power iii) Types of error 5. Explain the procedure for applying the tests of significance on a given data set. 6. Apply the appropriate test of significance on a set of data: i) z-test ii) t-test (paired / pooled) iii) Chi-square iv) Test of proportions v) Correlation vi) ANOVA 7. Identify the types of error in a test of significance. 20 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 LEARNING STRATEGIES Objective No. 1,5 & 6 (i) 2,7 & 3 6 (ii) 6 (iv) & 2 6 (iii & v) TOPIC STRATEGY HOURS Sampling Distribution of means Test of significance Test for single mean Confidence interval for population mean Types of error p-value Sample Size Pooled t-Test Paired t-Test Lecture Small group session 3 3 Lecture Small group session 3 3 Lecture Small group session 2 3 Test of single proportion & test of two proportions Confidence interval for proportions Chi-Square test Correlation Lecture Small group session 3 3 Lecture Small group session 2 3 Total Hours 28 21 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 COURSE NO: 211 COURSE: HAEMOPOETIC SYSTEM Objectives: 1. Describe the composition, properties and functions of blood. 2. Describe the functions of following plasma proteins: a. i) Albumin ii) Globulin ( , , ) iii) Ceruloplasmin b. iv) -Fetoprotein v) Haptoglobin. vi) Transferrin c. vii) C reactive protein 3. Describe the site of origin and process of hemopoiesis with special reference to RBCs, WBCs and platelets. 4. Describe the Gross structure of the components of lymphoid organs (lymph node, tonsil, spleen and thymus). 5. Describe the Microscopic structure of the components of lymphoid organs (lymph node, tonsil, spleen and thymus). 6. Describe the development of the components of lymphoid system. 7. Describe the production of lymph and pattern of lymph flow from lymphatic capillaries to the venous system. 8. Identify on a given microscopic slide/illustration/laboratory data the various components of hematopoietic system with particular reference to: a. RBCs b. Lymphocytes c. Polymorphonuclear leukocytes (neutrophils) d. Basophils e. Eosinophils f. Monocytes g. Reticulocytes h. Platelets 9. Describe the structure, synthesis, and degradation of hemoglobin. 10. Describe the role of various hormones, vitamins and cofactors in the formation of RBC. 11. Interpret the cellular count in a given blood report with special reference to RBC, TLC, DLC and platelets. 12. Describe the various blood group systems, with special reference to ABO and Rh blood group systems. 13. Describe the complications of transfusion with particular reference to: a. ABO mismatch b. Rh incompatibility and hemolytic anemia of the newborn. c. Transmission of infections 14. Describe the mechanism of hemostasis (intrinsic and extrinsic pathways) and pathogenesis of thrombosis. 15. Describe the physiological mechanisms that promote the dissolution of a blood clot. 16. Analyze the following on basis of signs and symptoms, genetic susceptibility and clinical data: a. Hypochromic microcytic b. Normochromic microcytic 22 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 c. Normochromic normocytic d. Macrocytic (megaloblastic) e. Sickle cell disease f. Thalassemia g. Primary polycythemia. h. Secondary polycythemia i. Purpura j. Hemophilia k. Von Willebrand’s disease 17. Describe briefly the types, pathogenesis & clinical features of leukemia. 18. Describe briefly the types, pathogenesis & clinical features of lymphoma (Hodgkin, Non Hodgkin). 19. Describe the drugs used for the treatment of anemia and other hemopoetic disorders. 20. Describe the mechanism of action, clinical uses, adverse effects, common drugdrug interactions and contraindications of the following: a. Antiplatelet drugs b. Anticoagulant drugs c. Thrombolytic drugs Skills: 21. Perform estimation of hemoglobin concentration by cyanmethemoglobin method. 22. Perform estimation of ESR by Westergren method. 23. Perform bleeding time and clotting time. 24. Prepare peripheral blood film (thick and thin). 25. Demonstrate the Hb-Electrophoresis 26. Identify the various parts and their uses of Langerdoff”s and Dales . 23 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 LEARNING STRATEGIES TOPIC Composition, properties and functions of blood Hemopoiesis Gross and microscopic features of the components of hemopoietic and lymphoid system Development of the components of hemopoietic and lymphoid system Structure, synthesis and degradation of heme Types of hemoglobin Types of anemia & polycythemia and their treatment ABO and Rh blood group systems and.. complications of transfusion and plasma expanders Lymphatic flow Plasma proteins Extrinsic and Intrinsic clotting pathways. Consequences of thrombosis Classification of leukemia Classification of lymphoma Agents used in anemia and hemopoietic growth factors Coagulation disorders, antithrombotics, thrombolytics Anticoagulants, antiplatelets Thrombolytics Various types of emboli Identify the blood cells in the slide Estimation of hemoglobin concentration Demonstration of Hb electrophoresis Estimation of ESR by Westergren method Bleeding time and clotting time STRATEGY CBS CBS Lecture Practical HRS. 1 1 2 10 Lecture 2 Lecture CBS PBL CBS Lecture CBS Lecture CBS Lecture Lecture Lecture 2 2 4 2 1 2 1 2 1 2 2 Lecture 1 PBL 4 Lecture Lecture CBS Practical Practical Practical Practical Practical Total 1 1 2 2 2 2 2 2 56 24 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 COURSE NO: 224 IMMUNE SYSTEM: Objectives: 1. Describe following types of immunity: a. Natural immunity b. Acquired immunity, c. Active immunity d. Passive immunity. 2. Differentiate between antigen and hapten, and discuss antigen presentation at different sites. 3. Describe the production, structure and functions of T cells. 4. Describe the production, structure and functions of B cells, plasma cells, and antibodies (IgA, IgD, IgE, IgG, and IgM) in bone marrow. 5. Describe the functions of the cytokines (Interleukins, Tumor necrosis Factors, Interferon Factor, Platelets Drive Growth Factor and Platelet Activating Factors). 6. Describe primary and secondary immune response (T, B & scavenger cells). 7. Describe the sequence of events in the development of cell-mediated and humoral immune response following first and second exposures to antigens with particular reference to BCG, Hepatitis B and polio vaccines. 8. Describe the role of vitamin D in immunity. 9. Describe the steps of complement pathways and its functions. 10. Define Isograft, Autograft, Allograft and Xenograft. 11. Describe histocompatibility antigens (HLA) and histocompatibility testing. 12. Describe the different types of hypersensitivity reactions. 13. Describe the mechanism involved in autoimmunity. 14. Describe the mechanism involved in immunodeficiency disorders. 15. Describe transplant rejection reactions and graft-versus-host disease. 16. Describe the role of inflammation in defense mechanisms of the body. 17. Describe the mechanism of vascular changes in acute inflammation. 18. Describe the following cellular events in acute inflammation: a) Margination b) Diapedesis c) Chemotaxis d) Opsonization e) Pavementation f) Degranulation 19. Describe the role of local and systemic mediators in acute inflammation. 20. Describe the role of cytokines in acute inflammation. 21. Describe the systemic effects of acute inflammation. 22. Describe the mechanism of chronic inflammation. 23. Describe the mechanism of chronic granulamatous inflammation. 24. Describe the mechanism of action, uses and adverse effects of ecosinoids. 25. Classify NSAIDS. Describe the mechanism of action, uses and adverse effects of NSAIDS. 26. Describe the mechanism of action of Aspirin and paracetamol toxicity. 27. Describe the mechanism of action, uses and adverse effects of immunemodulating drugs. 25 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 LEARNING STRATEGIES TOPIC Natural and acquired immunity, active and passive Immunity Antigen presentation Cell mediated immunity and humoral immunity Primary and secondary immune response Role of vitamin D in immunity Autoimmunity Hypersensitivity reactions Complement pathway Histocompatibility antigens Transplant rejection Immunodeficiency disorder Overview of immune modulation drugs Acute inflammation Acute inflammation and anti-inflammatory drugs Mediators of acute inflammation Role of cytokines in acute inflammation Exudate and transudate Chronic inflammation Systemic effects of inflammation Eicosanoids NSAIDs Immune modulating and suppressing agents Aspirin and Paracetamol toxicity Langerdroff’s and Dale’s apparatus Wound healing Outcome of healing and repair Morbidity and mortality due to immunizable diseases Aims and objectives of EPI and criteria for inclusion of specific vaccines Schedule of EPI Indications, contraindications and adverse reactions of vaccines in EPI Importance of cold chain for vaccines Bleeding Disorders STRATEGY HRS. CBS 2 Lecture PBL CBS CBS CBS CBS Lecture Lecture PBL Lecture Lecture Lecture PBL Lecture Lecture CBS Lecture Lecture Lecture Lecture Lecture CBS Practical PBL Lecture Lecture 1 4 2 2 1 2 1 1 1 1 2 1 4 1 1 1 1 1 1 1 2 2 2 4 1 1 Lecture 1 Lecture 1 Lecture 2 Lecture Lecture Total 1 2 51 26 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 Learning Resources Recommended Books Anatomy K.L. Moore. Clinically Oriented Anatomy, 6th edition 2009. B Young, J.W. Heath. Wheater’s Functional Histology, 5th edition 2006. Keith L. Moore. The Developing Human 9th edition 2011. Medical Histology by Laiq Hussain 4th ediation 1999. Richard S. Snell. Clinical Anatomy for Medical Students, 9th edition 2011. Langman’s Medical Embryology 12th edition 2011. Physiology Arthur C. Guyton, John E. Hall. Textbook of Medical Physiology, 12th edition 2010. Recommended Robert M. Berne, Matthew N. Levy. Principle of Physiology, 5th edition 2006. William F. Ganong. Review of Medical Physiology,24th edition 2012. Sherwood, Lauralee. Human physiology : from cells to systems 8th edition 2012. Bijlani, R.L. Understanding Medical physiology : a textbook of medical students 4th edition 2012. Biochemistry Robber K. Murray, Daryl K. Granner, Peter A. Mayes, Victor W. Rodwell. Harper’s Biochemistry, 29th edition 2012. Pamela C. Champe, Richard A. Harvey. Lippincott’s Illustrated Review of Biochemistry, 5th edition 2010. Harold C. Sox Jr. Common Diagnostic Tests, use and interpretation 2nd edition 1990. Jhon F. Zilva, Peter R. Pannall, Philip D. Mayne. Clinical Chemistry in Diagnosis and Treatment, 5th edition 1988. U. Satyanarayana. Biochemistry 2006. Community Health Sciences Mohd. Ilyas et. Al. Community Medicine and Public Health, 7th edition 2006. Kumza JW, Bohnenblust SE, Basic Statistics for the Health Sciences, 5th Edition 2005. CHS Course Book (available from CHS / ZU). Pharmalcology Bertram G. Katzung. Basic and Clinical Pharmacology, 12th Edition. 2011. Bennett and Brown. Clinical Pharmacology, 11th Edition. 2012. 27 st Ziauddin University MBBS 1 Year 2013– 2014 Semester 2 Goodman and Gillman. The Pharmacological Basis of Therapeutics, 12th Edition. 2011. Rang, Dale, Ritter and Moore. Pharmacology, 7th Edition. 2012. Tripathi. Essentials of Medical Pharmacology. 6th Edition. 2008. Pathology Peter D. Turnpenny, Emery’s Elements of Medical Genetics (14th ed.). New York: Churchill Livingstone. 2011. Cotran RS, Kumar V and Collins T. Robbin’s Pathologic Basis of Disease (8th ed.). Philadelphia: W.B. Saunders. 2012. Walter JB and Talbot IC. Walter and Israel’s General Pathology (7th ed.). New York: Churchill Livingstone. 1996. Kumar V, Cotran RS, and Robbins SL. Basic Pathology (9th ed.). Philadelphia: W.B. Saunders. 2012. Rubin E, Pathology (6th ed.) Philadelphia: Lippincott-Raven. 2011 Ivan Roitt. Riott’s Essential Immunology (12th ed.). New Delhi:I.K. International Pvt. Ltd. 2011. Wheater P et al. Basic Histopathology: A Color Atlas and Text (4th ed.). Edinburgh: Churchill Livingstone. 2002. Computer Assisted Learning: Topic - Catalogue # Interactive Atlas of Human Anatomy Explorations in Cell Biology and Genetics Interactive Physiology Wheater’s Interactive Histology Radiological Anatomy Imaging Atlas of Human Anatomy 2.0 Human Anatomy Virtual Human Atlas Comprehensive Microscopic Anatomy Video: Statistics. Decisions through Data. 43 and 116 44 and 115 48 52 54 67 76 78 77 12-16 28 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 STUDENT CODE OF CONDUCT 1. 1.1 1.2 1.3 2. 2.1 INTRODUCTION: The ZU was established with the objective of developing human resources appropriately equipped to deal with the problems, which are of particular relevance to its environment. The University considers its students to be mature and responsible individuals and makes all efforts for developing matching professional attributes. The University expects that behaviour of the students, within and outside the premises of the University, should be in conformity with the highest standards of honesty, morality and discipline. The students should respect the rights and privileges of the members of the University community at all times. They should refrain from conduct that might damage the reputation of the University or any of its programmes. The students should refrain from any conduct that may lead to the disruption of an academic programme of the University and from cheating and plagiarism in any setting of the University. THE CONDUCT OF STUDENTS: GENERAL CONDUCT: All students should present themselves with dignity befitting their status as mature professionals and responsible citizens. a. Students in all settings on campus are expected to dress in a simple and decent manner. b. Students individually or as a group, should obtain written ZU approval before organizing or assisting in organizing demonstrations, rallies or picketing on campus. c. Students individually or as a group should refrain from disseminating or causing to disseminate material or engage in activity which hinder or prevent the full participation of another person or group in the life of the University. d. Religious and social activities held on campus must have prior written University authorization. e. Students should ensure that their actions do not endanger or threaten the health, safety or well being of other persons. f. Students should refrain from any behaviour, which can be interpreted by others as sexual harassment. g. Students should obtain written authorization before making public statements, communication, or correspondence with the press or other media for mass communication on behalf of the University. h. Unless otherwise authorized in writing the students should refrain from inviting government and or foreign dignitaries, ministers, representatives of 29 Ziauddin University I. 2.2 st MBBS 1 Year 2013– 2014 Semester 2 foreign governments/agencies or other public personalities in their official capacity on campus. Students should refrain from any activity, which is subversive of discipline and may constitute misconduct. ACADEMIC CONDUCT: All students should diligently apply themselves to their registered courses of study. They should respect the confidentiality of information and should use it in no other circumstances than for professional and authorized academic purposes. a. Students should attend lectures, PBLs, tutorials, seminars, practicals, clinics and ward assignments, examinations and other scheduled courses, activities and assignments given by the faculty except for reasons acceptable to the University. b. Students should ensure that any original academic writing, including essays, theses, research projects or assignments in a course or programme of study either represents their own words, ideas, images or data or is appropriately referenced. c. Students should obtain authorization before procuring, possessing, distributing or receiving any confidential material pertaining to academic tests, examinations, research or laboratory results from any source. d. Students should respect the confidentiality of information pertaining to patients, including their records or files. RULES: 1. INTRODUCTION: 1.1 Students of ZU are required to exhibit good attitude and discipline. Guidelines have been delineated in the University’s Code of Conduct (“Code of Conduct”) framed by the University to provide students with a reference to the standards for discipline. It is expected that all students will strictly uphold and adhere to the Code of Conduct, but in cases where there are grounds to suspect a breach or any infringement of the Code of Conduct or disregard or contempt of the Code of Conduct, disciplinary action may be initiated for such behaviour committed either within or outside the precincts of the University or any establishment, project or setting thereof anywhere located. The reference to the expression “University” shall mean and include (unless the context provides otherwise), any establishment, project or setting of the University located anywhere in the world. 1.2 The disciplinary procedure to be followed upon breach and /or infringement of the Code of Conduct is defined herein, along with the actions, which constitute disciplinary offences and the decision-making authority. 30 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 2. DISCIPLINARY OFFENCE: Without prejudice to the generality of the provisions of the Code of Conduct and the provisions of Rules 1.1 and 1.2, the following conduct will constitute disciplinary offence: 1.1. MINOR OFFENCES: a. Repeated failure to conform to scheduled instruction, practical work, examination, clinical assignments and or forcing other students to act likewise. b. Smoking, eating and drinking are prohibited in the University Premises. NOTE: All minor offences will be dealt with as major if repeated. 1.2. a. b. c. d. e. f. g. h. i. MAJOR OFFENCES: Assault on students, members of staff, faculty or patients. Any form of unauthorized picketing, rallies, demonstrations or organized obstructions of any student/University/University Hospital function in any manner whatsoever. Any attempt to conceive, design or affect any plans of whatever nature whose object or consequence is to disrupt academic programmes of the University or its operations. Malicious acts, theft, willful damage or misuse of University property. Disorderly conduct and/or molestation of other members of the University Community within and outside the University premises. Bringing unauthorized persons in the university premises or any other building related to the University. Cheating, plagiarism and or use of unfair means in examinations or any other academic setting. Possession, use and display of firearms, drugs, alcohol or other contraband items on campus or at University related events. Any other offence, which is considered to be harmful to the academic atmosphere. DISCIPLINARY ACTIONS: The University will have the powers to impose any one or more of the following actions. However, nothing will preclude the University from requiring any student or parent or both to execute any bond, assurance or undertaking to support expected conduct throughout his/her stay at the University. MINOR DISCIPLINARY OFFENCE will be liable to one or more of the following sanctions. a) Counselling of the student. b) Probation: A student can be put on probation for a specified period of time with mandatory periodic counseling. 31 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 c) A letter of warning or reprimand to the student with information to the parents. d) The payment of fine by the offender commensurate with the nature and gravity of the offence committed amounting up to 5% of the annual fees of the student. MAJOR DISCIPLINARY OFFENCE will be liable to one or more of the following sanctions a) The payment of fine by the offender commensurate with the nature and gravity of the offence committed amounting up to 5% of the annual fees of the student. b) Suspension from the University for a specified period. c) Expulsion from the University. d) Any other penalty which the University may deem fit to impose. DISCIPLINARY PROCEDURE: The following steps constitute the disciplinary procedure. 4.1 Any disciplinary offence not of serious nature may be brought to the attention of the offender by an affected student through the faculty/staff member concerned of the University. The purpose of this in the first instance is to resolve the matter through constructive criticism ounseling and/or admonition. The expression “offence not of serious nature” appearing herein above shall be such offence as is considered as an offence of not a serious nature by the faculty/staff member of the University in his/her sole discretion. The expression “faculty/staff member of the University” shall be in relation to the following Units of the University namely, (i) Medical College, (ii) College of Nursing, (iii) College of Physical Therapy (iv) School Medical Technology (v) College of Pharmacy. (vi) College of Speech Language Therapy (vii) Dental college (viii) Faculty of Media Sciences. 4.2 If the matter is not resolved or the student repeats an offence or if the offence is a serious one, the head of the Unit concerned i.e. (i) in the case of Medical College/College of Pharmacy – the Dean, (ii) in the case of school of Medical & CSLT Technology – the Director and (iii) in the case of school of Physiotherapy / School of Nursing respective dean/Principals or their designate will be informed, who shall advise investigation by the Disciplinary Committee constituted under Rule 5.1. The outcome of the investigation shall be communicated to the head of the relevant Unit. He/she may act upon the recommendation of the Disciplinary Committee or in accordance with his/her judgment. The decision shall then be communicated to the offender. The matter shall be resolved normally within fourteen working days of the day the Head of the Unit is informed of the offence. 4.3 A student may appeal in writing against such a decision to the Head of his Unit within ten working days of the decision having been communicated in writing to 32 Ziauddin University 4.4 4.5 5. 5.1 5.2 5.3 6. st MBBS 1 Year 2013– 2014 Semester 2 the student. The student shall within the said period of time submit his/her appeal to the Head of his/her Unit i.e. Dean or his designate in the case of Medical College and College of Pharmacy, Dental College, College of Nursing– (ii) in the case of Institute of Medical Technology the Director and (iii) in the case of College of Physical Therapy Principal as the case may be for onward submission to the Vice Chancellor. The Head of the Unit shall request the Vice chancellor to constitute the Appeal Committee under Rule 5.2 and refer the matter to it for consideration of the appeal. The Appeal Committee shall take up and review the case and communicate its decision in writing to the VC normally within ten working days. The VC may act upon the recommendations of the Appeal Committee or in accordance with his/her own judgment. If the decision is not acceptable to the student, he/she may request a final review by the VC. The VC’s decision thereafter shall be final and binding. STRUCTURE OF THE DISCIPLINARY AND APPEAL COMMITTEES: The structure of Disciplinary Committee shall consist of five members of the faculty, one of whom shall be the Chairperson. The Chairperson and members may serve for three years. They may be appointed for another term of two years. The Committee shall be appointed by the ZU Academic Council. A University Appellate Committee shall be appointed as and when required, by the VC. It shall consist of three faculty members (one of whom shall be the chairperson) who have not been associated with ounseling or with investigation of the student’s current or his/her any previous offence. The Disciplinary Committee and the Appellate Committee will have authority to call for evidence or questioning any person witness to the offence/ event reported for investigation to the disciplinary committee. DISCIPLINARY AUTHORITY: Notwithstanding anything contained herein, the VC shall be the final disciplinary authority of the University with powers to: Appoint or change a Disciplinary Committee and define disciplinary procedures. a. Suspend the privileges of enrolment of a student who is suspected of a breach of the code, pending investigation. b. Act upon the recommendations of the Disciplinary Committee which may include expulsion of a student from the University. c. Appoint an Appeal Committee and define procedures for appeal. d. Take any measure that may be necessary for ensuring effective disciplinary procedures. e. Delegate any of his authority. f. Make, alter and modify the Disciplinary Procedure (Rules). 33 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 DEFINITIONS: The said expression shall mean and include any person enrolled with the University for a course of studies leading to an undergraduate or postgraduate degree or diploma or certificate within the University or the University Hospital or any person registered with any other University or Institution who has been accepted for an approved programme of study or training at ZU. Vice Chancellor: The VC shall be deemed to mean the VC of the University unless otherwise stated. Dean: Unless otherwise indicated, the “Dean” shall be interpreted as the Dean of (a) Medical College. (b) Post Graduate Studies. (Clinical / Basic) (c) Pharmacy. (d) College of Nursing Unit: Unless otherwise indicated, a unit shall mean the Medical College, College of Physical Therapy, College of Pharmacy or any Institute, College or School of the University. Head of the Unit: Shall mean Director of the Medical Technology & College of SLT, Principle of College of Physiotherapy and Dental College, Dean or his/her designate for the Medical College, Pharmacy. Suspension: Suspension requires a student to withdraw completely from all the activities of the University for a specified period of time. Upon expiry of the period of suspension the student will be re-admitted, contingent upon the terms and conditions of the suspension without any obligation or liability whatsoever on the part of the University or any of its staff/faculty members or officers. Expulsion: Expulsion means termination of enrolment in the University. Interns and Residents: These shall be deemed to be the students of the University. 34 Ziauddin University st MBBS 1 Year 2013– 2014 Semester 2 Fine: This is an order to student for payment of a sum of money to the University as penalty for any offence committed by the student. The student may or may not be permitted to continue with the course of studies until the fine has been paid. END 35
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