Max Hilz - European Medicines Agency

Transcription

Max Hilz - European Medicines Agency
Curriculum vitae
PERSONAL INFORMATION
Max Hilz
WORK EXPERIENCE
February 1981–April 1982
Resident
Hospital of the City of Nuremberg, (Germany)
Training in anesthesia and intensive care medicine
May 1982–September 1982
Resident, Dept. of ENT
University of Erlangen-Nuremberg, (Germany)
Training in ear-nose and throat diseases and in the diagnosis of vertigo and dizziness
October 1982–June 1984
Resident, Dept. of Neurology
University of Erlangen-Nuremberg, (Germany)
Training in General Neurology
July 1984–August 1986
Resident, Dept. of Psychiatry
University of Erlangen-Nuremberg, (Germany)
Training in Psychiatry
September 1986–June 1990
Resident and Board Certified Neurologist
University of Erlangen-Nuremberg, (Germany)
Clinical Neurophysiology; Intensive Care Neurology; general neurology
July 1990–December 1990
Fellowship in Neuroradiology
University of Erlangen-Nuremberg, (Germany)
Training in Neuroradiology
July 1991–September 1992
Oberarzt-Service, i.e. Attending Neurologist
University of Erlangen-Nuremberg, (Germany)
Clinical Neurophysiology, General Neurology, autonomic nervous system disorders
October 1992–June 1994
Visiting Professor, Dept. of Neurology
New York University, (United States)
Focus on autonomic nervous system diseases, particularly Hereditary Sensory and Autonomic
Neuropathies, orthostatic hypotension, diabetes, epilepsy etc
July 1994–September 2013
Attending Neurologist with admitting privileges
NYU Tisch Hospital, (United States)
Focus on autonomic nervous system diseases, particularly Hereditary Sensory and Autonomic
Neuropathies, orthostatic hypotension, diabetes, epilepsy etc
September 1994–November
1995
15/10/15
Medical Director, Neurodiagnostic Laboratory
NYUMC Tisch Hospital, (United States)
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Curriculum vitae
Max Hilz
Clinical Neurophysiology & Autonomic Nervous System Disorders
October 1995–August 2012
Consultant Neurologist
New York Veterans Affairs Medical Center, (United States)
Autonomic Nervous System Disorders
July 1996–July 2006
Director, Clinical Neurophysiology and Autonomic Nervous System
University Erlangen-Nuremberg, (Germany)
Clinical Neurophysiology & Autonomic Nervous System Disorders
September 1997–August 2013
Director of Autonomic Diseases Laboratory, Dept. of Neurology
New York University Medical Center, (United States)
Autonomic Nervous System Disorders
April 1999–December 2006
Associate Director, Dysautonomia Treatment and Evaluation Center
New York University Medical Center, (United States)
Autonomic Nervous System Disorders
April 1996–Present
Professor and Extraordinarius, Dept. of Neurology
University of Erlangen-Nuremberg, (Germany)
General Neurology, Clinical Neuropyhsiology, autonomic nervous system disorders
EDUCATION AND TRAINING
September 1964–June 1973
High school and College
Graf-Münster-Gymnasium Bayreuth, (Germany)
October 1973–October 1974
Medical School
University of Cologne, (Germany)
November 1974–December 1980
Medical School
Friedrich-Alexander University of Erlangen-Nuremberg, (Germany)
February 1981–April 1984
Resident, Dept. of Anesthesiology & Intensive Care Medicine
Hospital of the City of Nuremberg; Nuremberg, (Germany)
May 1982–September 1982
Resident, Department of ENT
University of Erlangen-Nuremberg, (Germany)
October 1982–June 1984
Resident, Dept. of Neurology
University of Erlangen-Nuremberg, (Germany)
July 1984–August 1986
Resident, Dept. of Psychiatry
University of Erlangen-Nuremberg, (Germany)
15/10/15
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Curriculum vitae
September 1986–March 1988
Max Hilz
Resident, Dept. of Neurology
University of Erlangen-Nuremberg, (Germany)
March 1988–June 1990
Fellow and Board Certified Neurologist
Dept. of Neurology, University of Erlangen-Nuremberg, (Germany)
July 1990–December 1990
Fellowship in Neuroradiology
Department of Neuroradiology, University of Erlangen-Nuremberg, (Germany)
ADDITIONAL INFORMATION
Expertise
I have more than 25 years of experience with autonomic nervous system disorders and conducted
many international studies in an autonomic laboratory at New York University, New York, NY, USA,
and at the UNiversity of Erlangen-Nuremberg, Erlangen, Germany.
To better understand autonomic feedback loops and organ interactions, we use sophisticated testingprocedures, such as combined chemoreflex and sinusoidal baroreflex stimulation.
We studied a wide spectrum of autonomic disorders associated with common diseases, such as
diabetes, obesity, stroke, epilepsy, traumatic brain injury, Parkinson disease, Multiple Sclerosis,
Guillain-Barré-Syndrome, amyotrophic lateral sclerosis, normal-pressure glaucoma, Syncope or
POTS, as well as rare hereditary or neurodegenerative disorders, including Hereditary Sensory and
Autonomic Neuropathies Fabry disease.
I am particularly interested in the effects of central autonomic network lesions on the cardiovascular
system, e.g. in patients with epilepsy, multiple sclerosis, stroke or traumatic brain injury, in orthostatic
hypotension and postural tachycardia syndrome (POTS).
Publications
Peer Reviewed Original Contributions
1. Schellmann B, Hilz MJ, Opitz O (1980) Cadmium- und Kupferausscheidung nach Aufnahme von
Champignon-Mahlzeiten. Z Lebenssm Unters Forsch, 171:189-92 [Conception and design of Study,
Data analysis and interpretation, drafting or revising critically important intellectual content]
2. Claus D, Hilz MJ, Hummer I, Neundörfer B (1987) Methods of measurement of thermal thresholds.
Acta Neurol Scand, 76:288-96 (IF 1.71) [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
3. Hilz MJ, Claus D, Neundörfer B (1988) Early diagnosis of diabetic small fiber neuropathy by
disturbed cold perception. J Diabetes Complicat, 2:38-43 (IF 1.86)
4. Hilz MJ, Huk W, Druschky KF, Erbguth (1989) Fat deposition surrounding intracerebral hemorrhage
in a patient suffering from Zieve-syndrome. Neuroradiology, 31:102-3 (IF 1.51)
5. Bauer J, Stefan H, Huk WJ, Feistel H, Hilz MJ, Brinkmann HG, Druschky KF, Neundörfer B (1989)
CT, MRI and SPECT neuroimaging in Status epilepticus with simple partial and complex partial
seizures: case report. J Neurol, 236:296-99 (IF 3.14) [Conception and design of Study, Data analysis
and interpretation, drafting or revising critically important intellectual content]
6. Druschky KF, Pfurtscheller G, Litscher G, Hilz MJ, Schwarz G, Jahns I, Neundörfer B (1989) Visuell
evozierte Potentiale bei primär infra- und supratentoriellen Läsionen. Visual evoked potentials in
patients with primary infratentorial and supratentorial lesions. Intensivbehandlung, 14:168-73
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
7. Mösler TA, Koniszewski G, Barocka A, Höll R, Hilz MJ, Frontzek T, Rossa U (1989) Psychogene
Störungen des visuellen Systems. Eine Studie an Erwachsenen und Kindern. Augenärztliche
Fortbildung, 12:54-61 [Data interpretation, drafting or revising critically important intellectual content]
8. Hilz MJ, Bauer J, Druschky KF, Huk WJ, Neundörfer B (1990) Zieve's syndrome and intracranial
hemorrhage: coincidence or related disorders. J Neurol, 237:120-21 (IF 3.14)
9. Hilz MJ, Druschky KF, Bauer J, Neundörfer B, Schuierer G (1990) Morbus Wilson - kritische
Verschlechterung unter hochdosierter parenteraler Penicillamin-Therapie. Wilson's disease deterioration with high-dosage parenteral penicillamine treatment. Dtsch Med Wschr, 115:93-97
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Curriculum vitae
Max Hilz
10. Hilz MJ, Claus D, Bauer J, Neundörfer B (1990) Transkutaner Herzschrittmacher in der
Prophylaxe und Notfalltherapie bei Neurologischen Intensivpatienten. Nervenarzt; 61:744-48 (IF 0.89)
11. Hilz MJ, Huk W, Schellmann B, Sörgel F, Druschky KF (1990) Fatal complications after
myelography with meglumine diatrizoate. Neuroradiology, 32:70-73 (IF 1.51)
12. Weis M, Hilz MJ, Claus D, Neundörfer B, Druschky KF, Litscher G, Pfurtscheller G (1990) Longtime monitoring - Options to use on patients in neurologic intensive care units. J Clin Monitoring,
6:168-69 [Conception and design of Study, Data analysis and interpretation, drafting or revising
critically important intellectual content]
13. Hilz MJ, Neundörfer B, Engelhardt A, Claus D, Grahmann F (1990) Idiopathische
Polyradikuloneurits Landry-Guillain Barré nach Kohlenmonoxyd-Vergiftung. Landry-Guillain-Barré
Syndrome after Carbon Monoxide Intoxication. Akt Neurol, 17:113-16 (IF 0.33)
14. Claus D, Hilz MJ, Neundörfer B (1990) Thermal discrimination thresholds: a comparison of
different methods. Acta Neurol Scand, 81:533-40 (IF 1.71) [Conception and design of Study, Data
analysis and interpretation, drafting or revising critically important intellectual content]
15. Erbguth F, Druschky KF, Gmeiner HJ, Hilz MJ, Neundörfer B (1990) Bilaterale Thalamusläsionen
bei Hirnvenenthrombosen. Nervenarzt, 61:123-26 (IF 0.89) [Data interpretation, drafting or revising
critically important intellectual content]
16. Hilz MJ, Litscher G, Weis M, Claus D, Druschky KF, Pfurtscheller G, Neundörfer B (1991)
Continuous multivariable monitoring in neurological intensive care patients - preliminary reports on
four cases. Intensive Care Med, 17:87-93 (IF 3.03)
17. Rechlin T, Hilz MJ, Claus D (1991) Erfolgreiche Behandlung des malignen neuroleptischen
Syndroms mit Dantrolen-Natrium i.v. auf der neurologischen Intensivstation. Anästhesiol Intensivmed.
Notfallmed. Schmerzther, 26:156-60 [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
18. Bauer J, Schüler P, Feistel H, Hilz MJ, Stefan H (1991) Blindness as an ictal phenomenon. Investigations with EEG and SPECT in two patients suffering from epilepsy. J Neurol, 238:44-46 (IF 3.14)
[Data interpretation, drafting or revising critically important intellectual content]
19. Hilz MJ, Bauer J, Claus D, Stefan H, Neundörfer B (1992) Isoflurane anaesthesia in the treatment
of convulsive status epilepticus. J Neurol, 239:135-37 (IF 3.14)
20. Hilz MJ, Claus D, Balk M, Neundörfer (1992) Influence of caffeine, sweating and local
hyperemisation on "Marstock" thermotesting. Acta Neurol Scand, 86:19-23 (IF 1.71)
21. Hilz MJ, Claus D, Druschky KF, Rechlin T (1992) Air fluidization therapy of pressure sores due to
Guillain-Barré and Cushing syndrome. Intensive Care Med, 18:62-63 (IF 3.03)
22. Hilz MJ, Litscher G, Pfurtscheller G, Schwarz G, Druschky KF, Neundörfer B (1993) Visuell
evozierte Potentiale: Zum Einfluß primärer Hirnstammläsionen auf die Skalp-Topographie. Z EEG
EMG, 24:258-62
23. Hilz MJ, Claus D, Neundörfer B, Zimmermann P, Beric A (1994) Is heat hypoalgesia a useful parameter in quantitative thermal testing of alcoholic polyneuropathy? Muscle Nerve, 17:1456-60 (IF 2.43)
24. Hilz MJ, Zimmermann P, Claus D, Neundörfer (1995) Thermal threshold determination in alcoholic
polyneuropathy - an improvement of diagnosis. Acta Neurol Scand, 91:389-93 (IF 1.71)
25. Hilz MJ, Glorius S, Beric A (1995) Thermal perception thresholds: influence of determination
paradigm and reference temperature. J Neurol Sci, 129:135-40 (IF 2.37)
26. Hilz MJ, Erbguth F, Stefan H, Neundörfer B (1995) Isoflurane for seven days in refractory status
epilepticus. Eur J Neurol, 2:95-99 (IF 2.22)
27. Hilz MJ, Claus D, Rösl G, Hofmann E, Braun J, Neundörfer B (1995) Besserung des TemperaturundVibrationsempfindens bei chronischer Urämie nach Einzeldialyse. Fortschr Neurol Psychiat,
63:264-69 (IF 0.75)
28. Hilz MJ, Zimmermann P, Rösl G, Scheidler W, Braun J, Stemper B, Neundörfer B (1995)
Vibrameter testing facilitates the diagnosis of uremic and alcoholic polyneuropathy. Acta Neurol
Scand, 92:486-90 (IF 1.71)
29. Hilz MJ, Glorius SE, Schweibold G, Neuner I, Stemper B, Axelrod FB (1996) Quantitative thermal
perception testing in preschool children. Muscle Nerve, 19:381-83 (IF 2.43)
30. Neundörfer B, Hilz MJ, Wimbauer M (1996) Zum Verlauf und zur Prognose von Patienten einer
neurologischen Intensivstation unter besonderer Berücksichtigung des Alters. Fortschr Neurol
Psychiat; 64:285-91 (IF 0.75) [Conception and design of Study, Data analysis and interpretation,
drafting or revising critically important intellectual content]
31. Grahmann F, Schober S, Hilz MJ (1996) Neundörfer B. Late life polyneuropathy. AGE, 19:13-16
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Curriculum vitae
Max Hilz
(IF 1.64) [Conception and design of Study, Data analysis and interpretation, drafting or revising
critically important intellectual content]
32. Warner LE, Hilz MJ, Appel SH, Killian JM, Kolodny EH, Karpati G, Carpenter S, Watters GV,
Wheeler C, Witt D, Bodell A, Nelis E, Van Broeckhoven C, Lupski JR (1996) Clinical phenotypes of
different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and
congenital hypomyelination. Neuron, 17:451-60 (IF 14.43) [Conception and design of Study, Data
analysis and interpretation, drafting or revising critically important intellectual content]
33. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (1997) Benign exertional
headache/benign sexual headache: a disorder of myogenic cerebrovascular autoregulation?
Headache, 37:597-98 (IF 2.30) [Conception and design of Study, Data analysis and interpretation,
drafting or revising critically important intellectual content]
34. Heckmann JG, Erbguth F, Hilz MJ, Huk W, Neundörfer B (1997) Effect of dopamine on middle
cerebral artery blood flow: a single case study. Neurol Psychiat Brain Res, 5:107-10 (IF 0.16) [Data
interpretation, drafting or revising critically important intellectual content]
35. Weiser M, Hilz MJ, Bronfin L, Axelrod FB (1998) Assessing microcirculation in familial
dysautonomia by laser Doppler flowmetry. Clin Auton Res, 8:13-23 (IF 0.83) [Conception and design
of Study, Data analysis and interpretation, drafting or revising critically important intellectual content]
36. Heckmann JG, Mück-Weymann M, Katalinic A, Hilz MJ, Claus D, Neundörfer B (1998) TCDErgometer-Test bei Patienten mit chronischem Kopfschmerz vom Spannungstyp (CKST). Nervenarzt,
69:131-36 (IF 0.89) [Data interpretation, drafting or revising critically important intellectual content]
37. Heckmann JG, Hilz MJ, Katalinic A, Marthol H, Mück-Weymann M, Neundörfer B (1998)
Myogenic cerebrovascular autoregulation in migraine measured by stress transcranial Doppler
sonography. Cephalalgia, 18:133-37 (IF 3.13) [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
38. Hilz MJ, Kolodny EH, Neuner I, Stemper B, Axelrod FB (1998) Highly abnormal thermotest in
Familial Dysautonomia suggests increased cardiac risk.J Neurol Neurosurg Psychiatry, 65:338-43 (IF
3.11)
39. Hilz MJ, Axelrod FB, Hermann K, Haertl U, Duetsch M, Neundörfer B (1998) Normative values of
vibratory per-ception in 530 preschool children, juveniles and adults aged 3 to 79 years. J Neurol Sci,
159:219-25 (IF 2.36)
40. Hilz MJ, Stemper B, Schweibold G, Neuner I, Grahmann F, Kolodny EH (1998) Quantitative
thermal perception testing in 225 children and juveniles. J Clin Neurophysiol,15:529-34 (IF 1.53)
41. Hilz MJ, Stemper B, Axelrod FB (1999) Sympathetic Skin Response differentiates Hereditary
Sensory Autonomic Neuropathies III and IV. Neurology, 52:1652-57 (IF 5.97)
42. Heckmann JG, Hilz MJ, Hagler H, Mück-Weymann M, Neundörfer B (1999) Transcranial Doppler
sonography during acute 80° head-down tilt (HDT) for the assessment of cerebral autoregulation in
humans. Neurol Res, 21:457-62 (IF 1.21) [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
43. Druschky A, Spitzer A, Platsch G, Claus D, Feistel H, Druschky K, Hilz MJ, Neundörfer B (1999)
Cardiac sympathetic denervation in early stages of amyotrophic lateral sclerosis demonstrated by
123-I-MIBG-SPECT. Acta Neurol Scand, 99:308-14 (IF 1.71) [Data interpretation, drafting or revising
critically important intellectual content]
44. Druschky K, Hilz MJ, Kölsch C, Platsch G, Neundörfer B (1999) Cardiac sympathetic denervation
in Ross syndrome demonstrated by MIBG-SPECT. J Auton Nerv Syst, 76:184-87 (IF 1.31)
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
45. Hilz MJ, Stemper B, Sauer P, Haertl U, Singer W, Axelrod FB (1999) Cold face test demonstrates
parasympathetic cardiac dysfunction in familial dysautonomia. Am J Physiol, 276:R1833-39 (IF 3.53)
46. Hecht M, Kober H, Claus D, Hilz M, Vieth J, Neundörfer B (1999) The electrical and magnetical
cerebral responses evoked by electrical stimulation of the esophagus and the location of their cerebral
sources. J Clin Neurophysiol, 110:1435-44 (IF 1.53) [Data interpretation, drafting or revising critically
important intellectual content]
47. Hilz MJ, Stemper B, Axelrod FB, Kolodny EH, Neundörfer B (1999) Quantitative thermal
perception testing in adults. J Clin Neurophysiol, 16:462-71 (IF 1.53)
48. Heckmann JG, Niedermeier W, Brandt-Pohlmann M, Hilz MJ, Hecht M, Neundörfer B (1999)
Detektion eines offenen Foramen ovale: Transösophageale Echokardiographie und transcranielle
Doppler-Sonographie mit Echovist sind „ergänzende, nicht-konkurrierende Methoden“. Med Klin, 36770 (IF 0.47) [Data interpretation, drafting or revising critically important intellectual content]
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Curriculum vitae
Max Hilz
49. Heckmann JG, Leis S, Mück-Weymann M, Hilz MJ, Neundörfer B (1999) Vestibular evoked blood
flow response in the basilar artery. Acta Neurol Scand, 100:12-17 (IF 1.71) [Data interpretation,
drafting or revising critically important intellectual content]
50. Hilz MJ, Axelrod FB, Schweibold G, Kolodny EH (1999) Sympathetic skin response following
thermal, electrical, acoustic and inspiratory gasp stimulation in Familial Dysautonomia patients and
healthy persons. Clin Auton Res, 9:165-77 (IF 0.83)
51. Saleh Y, Kirchner A, Pauli E, Hilz MJ, Neundörfer B, Stefan H (2000) Temporallappenepilepsien –
Einfluß der Fokusseite auf die autonome Regulation der Herzfrequenz? Nervenarzt, 71:477-80 (IF
0.89) [Data interpretation, drafting or revising critically important intellectual content]
52. Kilo S, Berghoff M, Hilz M, Freeman R (2000) Neural and Endothelial Control of the
Microcirculation in Diabetic Peripheral Neuropathy. Neurology, 54:1246-52 (IF 5.97) [Data
interpretation, drafting or revising critically important intellectual content]
53. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (2000) Transcranial Doppler
sonography – ergometer test for the non-invasive assessment of cerebrovascular autoregulation in
humans. J Neurol Sci, 177:41-47 (IF 2.36) [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
54. Hilz MJ, Stemper B, Kolodny EH (2000) Lower limb cold exposure induces pain and prolonged
small fiber dysfunction in Fabry patients. PAIN, 84:361-65 (IF 4.06)
55. Druschky A, Hilz MJ, Platsch G, Radespiel-Tröger M, Druschky K, Kuwert T, Neundörfer B (2000)
Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means
of I-123-MIGB-SPECT. J Neurol Sci, 175:3-12 (IF 2.36) [Conception and design of Study, Data
analysis and interpretation, drafting or revising critically important intellectual content]
56. Hilz MJ, M Hecht M, Berghoff M, Singer W, Neundörfer B (2000) Abnormal vasoreaction to
arousal stimuli - an early sign of diabetic sympathetic neuropathy demonstrated by Laser Doppler
flowmetry. J Clin Neurophysiol, 17:419-25 (IF 1.53)
57. Axelrod F, Zupanc M, Hilz MJ, Kramer EL (2000) Ictal SPECT during autonomic crisis in Familial
Dysautonomia. Neurology, 55:122-25 (IF 5.97) [Conception and design of Study, Data analysis and
interpretation, drafting or revising critically important intellectual content]
58. Hilz MJ, Axelrod FB (2000) Quantitative sensory testing of thermal and vibratory perception in
familial dysautonomia. Clin Auton Res, 10:177-83 (IF 0.83)
59. Reinhardt F, Wetzel T, Vetten S, Radespiel-Tröger M, Hilz MJ, Heuss D, Neundörfer B (2000).
Peripheral neuropathy in chronic venous insuffiency. Muscle Nerve; 6: 883-87 (IF 2.43) [Conception
and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual
content]
60. Heckmann JG, Hilz MJ, Hummel T, Popp M, Marthol H, Neundörfer B, Heckmann SM (2000) Oral
mucosal blood flow following dry ice stimulation in humans. Clin Auton Res, 10:317-21 (IF 0.83)
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
61. Hilz MJ, Dütsch M, Perrine K, Nelson PK, Rauhut U, Devinsky O (2001) Hemispheric influence on
autonomic modulation and baroreflex sensitivity. Ann Neurol, 49:575-84 (IF 8.09)
62. Druschky A, Herkert M, Radespiel-Tröger M, Druschky K, Hund E, Becker CM, Hilz MJ, Erbguth F,
Neundörfer B (2001) Critical illness polyneuropathy: Clinical findings and cell culture assay of
neurotoxicity assessed by a prospective study. Intensive Care Med, 27:686-93 (IF 3.03) [Data
interpretation, drafting or revising critically important intellectual content]
63. Hecht MJ, Neundörfer B, Kiesewetter F, Hilz MJ (2001) Neuropathy is a major contribution factor
to diabetic erectile dysfunction. Neurol Res, 23:651-54 (IF 1.21)
[Conception and design of Study, drafting or revising critically important intellectual content]
64. Hecht MJ, Fellner F, Fellner C, Hilz MJ, Heuss D, Neundörfer B (2001) MRI-FLAIR images of the
head show corticospinal tract alterations in the ALS patients more frequently than T2-, T1- and proton
density weighted images. J Neurol Sci, 186:37-44 (IF 2.36) [drafting or revising critically important
intellectual content]
65. Heckmann SM, Heckmann JG, Hilz MJ, Popp M, Marthol H, Neundörfer B (2001) Hummel T. Oral
mucosal blood flow in patients with burning mouth syndrome. PAIN, 90:281-86 (IF 4.06) [Data
interpretation, drafting or revising critically important intellectual content]
66. Singer W, Tonette L, Opfer-Gehrking, McPhee BR, Hilz MJ, Low PA (2001) Influence of posture on
the Valsalva manoeuvre. Clin Sci; 100: 433-40 (IF 2.16) [drafting or revising critically important
intellectual content]
67. Druschky A, Hilz MJ, Hopp P, Platsch G, Radespiel-Tröger M, Druschky K, Kuwert T, Stefan H,
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Curriculum vitae
Max Hilz
Neundörfer B (2001) Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated
by [123I]metaiodobenzylguanidine-SPECT. Brain, 124:2372-82 (IF 8.2) [drafting or revising critically
important intellectual content]
68. Hilz MJ, Devinsky O, Doyle W, Mauerer A, Dütsch M (2002) Decrease of sympathetic
cardiovascular modulation after temporal lobe epilepsy surgery. Brain, 125:985-95 (IF 8.2)
69. Dütsch M, Hilz MJ, Rauhut U, Solomon J, Neundörfer B, Axelrod FB (2002) Sympathetic and
parasympathetic pupillary dysfunction in familial dysautonomia. J Neurol Sci, 195:77-83 (IF 2.36)
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
70. Brown C, Dütsch M, Michelson G, Neundörfer B, Hilz MJ (2002) Impaired cardiovascular
responses to baroreflex stimulation in open-angle and normal-pressure glaucoma. Clin Sci,102:62330 (IF 2.16) [Conception and design of Study, Data analysis and interpretation, drafting or revising
critically important intellectual content]
71. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R (2002) Vascular and neural mechanisms of
Ach-mediated vasodilatation in the forearm cutaneous mircrocirculation. J Appl Physiol, 92:780-88 (IF
2.82) [drafting or revising critically important intellectual content]
72. Stemper B, Hilz MJ, Rauhut U, Neundörfer B (2002) Evaluation of cold face test bradycardia by
means of spectral analysis. Clin Auton Res, 12:78-83 (IF 0.83) [Conception and design of Study, Data
analysis and interpretation, drafting or revising critically important intellectual content]
73. Hilz MJ, Axelrod FB, Braeske K, Stemper B (2002) Cold pressor test demonstrates residual
sympathetic cardiovascular activation in familial dysautonomia. J Neurol Sci, 196:81-89 (IF 2.36)
74. Hilz MJ, Axelrod FB, Haertl U, Brown CM, Stemper B (2002) Transcranial Doppler sonography
during head up tilt suggests preserved central sympathetic activation in familial dysautonomia. J
Neurol Neurosurg Pschiat, 72:657-60 (IF 3.11)
75. Hecht MJ, Fellner F, Fellner C, Hilz MJ, Neundörfer B, Heuss D (2002) Hyperintense and
hypointense MRI signals of the precentral gyrus and the pyramidal tract in ALS - a follow up
examination including FLAIR images. J Neurol Sci, 199:59-65 (IF 2.36) [drafting or revising critically
important intellectual content]
76. Singer W, Win-Kuang S, Opfer-Gehrking L, McPhee BR, Hilz MJ, Low PA (2002) Evidence of an
instrinsic sinus node abnormality in patients with postural tachycardia syndrome. Mayo Clin Proc,
77:246-52 (IF 3.74) [drafting or revising critically important intellectual content]
77. Lang E, Hilz MJ, Erxleben H, Ernst M, Neundörfer B, Liebig K (2002) Reversible prolongation of
motor conduction time after transcranial magnetic brain stimulation following neurogenic claudication
in spinal stenosis. Spine, 7:2284-90 (IF 2.29) [drafting or revising critically important intellectual
content]
78. Hilz MJ, Axelrod FB, Steingrüber M, Stemper B (2002) Valsalva maneuver suggests increased
rigidity of cerebral resistance vessels in Familial Dysautonomia. Clin Auton Res, 12:385-92 (IF 0.83)
79. Kirchner A, Pauli E, Hilz MJ, Neundörfer B, Stefan H (2002) Sex differences and lateral
asymmetry in heart rate modulation in patients with temporal lobe epilepsy. J Neurol Neurosurg
Psychiatry, 72:73-75 (IF 3.11) [drafting or revising critically important intellectual content]
80. Sommer JB, Schoerner C, Heckmann JG, Neundörfer B, Hilz MJ (2002) Mononeuritis multiplex
due to Coixella Burnetii infection (Q fever). Acta Neurol Scand, 106:371-73 (IF 1.71) [revising critically
important intellectual content]
81. Bickel A, Krämer H, Hilz MJ, Birklein F, Neundörfer B, Schmelz M (2002) Assessment of the
neurogenic flare reaction in small fiber neuropathies. Neurology, 59:617-19 (IF 5.97) [ revising critically
important intellectual content]
82. Bickel A, Axelrod FB, Schmelz M, Marthol H, Hilz MJ (2002) Dermal microdialysis provides
evidence for hypersensitivity to norepinephrine in familial dysautonomia patients. J Neurol Neurosurg
Psychiatry, 73:299-302 (IF 3.11) [Conception and design of Study, Data analysis and interpretation,
drafting or revising critically important intellectual content]
83. Dütsch M, Marthol H, Stemper B, Brys M, Haendl T, Hilz MJ (2002) Small fiber neuropathy
predominates in Fabry neuropathy. J Clin Neurophysiol, 19:575-86 (IF 1.53) [Conception and design
of Study, Data analysis and interpretation, drafting or revising critically important intellectual content]
84. Hilz MJ, Hecht MJ, Mittelhamm F, Neundörfer B, Brown CM (2002) Baroreflex stimulation shows
impaired cardiovagal and preserved vasomotor function in early stage amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Other Motor Neuron Disord, 3:137-44 (IF 1.21) [Conception and design of
Study, Data analysis and interpretation, drafting or revising critically important intellectual content]
85. Hecht MJ, Hillemacher T, Gräsel E. Tigges S. Winterholler M, Heuss D, Hilz MJ, Neundörfer B
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Max Hilz
(2002) Subjective experience and coping in ALS. Amyotroph Lateral Scler Other Motor Neuron
Disord, 3:225-31 (IF 1.21) [drafting or revising critically important intellectual content]
86. Kolominsky-Rabas PL, Hilz MJ, Neundörfer B, Heuschmann PU (2003) Impact of urinary
incontinence after stroke: results from a prospective population-based stroke register. Neurourol
Urodynam, 22:322-27 (IF 3.65) [drafting or revising critically important intellectual content]
87. Werner D, Marthol H, Brown CM, Daniel WG, Hilz MJ (2003) Changes of cerebral blood flow
velocities during enhanced external counterpulsation (EECP). Acta Neurol Scand, 107:405-11 (IF
1.71)
88. Brown CM, Stemper B, Welsch G, Brys M, Axelrod FB, Hilz MJ (2003) Orthostatic challenge
reveals impaired vascular resistance control, but normal venous pooling and capillary filtration in
familial dysautonomia. Clin Sci, 104:163-69 (IF 2.16)
89. Bernardi L, Hilz MJ, Stemper B, Passino C, Welsch G, Axelrod FB (2003) Respiratory and
cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia. Am J Resp Crit
Care, 167:141-49 (IF 8.12) [Conception and design of Study, Data analysis and interpretation, drafting
or revising critically important intellectual content]
90. Singer W, Shen WK, Opfer-Gehrking TL, McPhee BR, Hilz MJ (2003) Heart rate-dependent
electrocardio-gramm abnormalities in patients with postural tachycardia syndrom. Auton Neurosci,
103:106-13 (IF 1.31)
91. Brown, CM, Hecht MJ, Weih A, Neundörfer B, Hilz MJ (2003) Effects of age on the cardiac and
vascular limbs of the arterial baroreflex. Eur J Clin Invest, 33:10-16 (IF 2.53)
92. Brown CM, Dütsch M, Hecht MJ, Neundörfer B, Hilz MJ (2003) Assessment of cerebrovascular
and cardiovascular responses to lower body negative pressure as a test of cerebral autoregulation. J
Neurol Sci, 208:71-78 (IF 2.36)
93. Stemper B, Hilz MJ (2003) Postischemic cutaneous hyperperfusion in the presence of forearm
hypoperfusion suggests sympathetic vasomotor dysfunction in Fabry disease. J. Neurology, 250:97076 (IF 5.97)
94. Hecht MJ, Brown CM, Mittelhamm F, Werner D, Neundörfer B, Hilz MJ (2003) Increased hypoxic
blood pressure response in patients with amyotrophic lateral sclerosis. J Neurol Sci, 213:47-53 (IF
2.36)
95. Brys M, Brown C, Marthol H, Franta R, Hilz MJ (2003) Dynamic cerebral autoregulation remains
stable during physical challenge in healthy persons. Am J Physiol C, 285:H1048-H54 (IF 3.53)
96. Stemper B, Axelrod F, Marthol H, Brown C, Brys M, Welsch G, Hilz MJ (2003) Terminal vessel
hyperperfusion despite organ hypoperfusion in familial dysautonomia. Clin Sci, 105:295-301 (IF 2.16)
97. Brown CM, Sanya EO, Hilz MJ (2003) Effect of cold face stimulation on cerebral bood flow in
humans. Brain Res Bull, 61:81-86 (IF 2.42)
98. Brown CM, Hecht MJ, Neundörfer B, Hilz MJ (2003) Effects of lower body negative pressure on
cardiac and vascular responses to carotid baroreflex stimulation. Physiol Res, 52:637-45 (IF 1.14)
99. Sanya EO, Brown CM, Dütsch M, Zikeli U, Neundorfer B, Hilz MJ (2003) Impaired cardiovagal
and vasomotor responses to baroreceptor stimulation in type II diabetes mellitus, Eur J Clin Invest,
33:582-88 (IF 2.53)
100. Marthol H, Tutaj M, Brys M, Brown C, Hecht M, Berlin D, Axelrod FB, Hilz MJ (2003) Clonidine
improves postprandial baroreflex control in familial dysautonomia. Eur J Clin Invest, 33:912-18 (IF
2.53)
101. Hilz MJ, Platsch G, Druschky K, Pauli E, Kuwert T, Stefan H, Neundörfer B, Druschky A (2003)
Outcome of epilepsy surgery correlates with sympathetic modulation and neuroimaging of the heart.
J Neurol Sci, 216:153-62 (IF 2.36)
102. Hecht MJ, Graesel E, Tigges S, Hillemacher T, Winterholler M, Hilz MJ, Heuss D, Neundörfer B
(2003) Burden of care in amyotrophic lateral sclerosis. Palliat Med, 17:327-33 (IF 1.12) [drafting or
revising critically important intellectual content]
103. Heckmann JG, Brown CM, Cheregi M, Hilz MJ, Neundörfer B (2003) Delayed cerebrovascular
autoregulatory response to ergometer exercise in normotensive elderly humans. Cerebrovasc Dis,
16:423-29 (IF 2.15) [Data analysis and interpretation, drafting or revising critically important intellectual
content]
104. Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA (2003)
Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic
hypotension. J Neurol Neurosurg Psychiatry, 74:1294-98 (IF 3.11) [drafting or revising critically
important intellectual content]
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Max Hilz
105. Brown CM, Dütsch M, Ohring S, Neundorfer B, Hilz MJ (2004) Cerebral autoregulation is
compromised during simulated fluctuations in gravitational stress. Eur J Appl Physiol, 91:279-86 (IF
2.82)
106. Bickel A, Axelrod FB, Marthol H, Schmelz M, Hilz MJ (2004) Sudomotor function in Familial
Dysautonomia, J Neurol Neurosurg Psychiatry, 75:275-79 (IF 3.11)
107. Hilz MJ, Brys M, Marthol H, Stemper B, Dütsch M (2004) Enzyme replacement therapy improves
function of C-, A delta- and A beta-nerve fibers in Fabry neuropathy. Neurology, 62:1066-72 (IF 5.97)
108. Tutaj M, Brown CM, Brys M, Marthol H, Hecht MJ, Dütsch M, Michelson G, Hilz MJ (2004)
Dynamic cerebral autoregulation is impaired in glaucoma. J Neurol Sci, 220:49-54 (IF 2.36)
109. Dütsch M, Marthol H, Michelson G, Neundörfer B, Hilz MJ (2004) Pupillography refines the
diagnosis of diabetic autonomic neuropathy. J Neurol Sci, 222:75-81 (IF 2.36)
110. Hilz MJ, Kolodny EH, Brys M, Stemper B, Haendl T, Marthol H (2004) Reduced cerebral blood
flow and impaired cerebral autoregulation in Fabry patients. J Neurol, 251:564-70 (IF 3.14)
111. Stemper B, Bernardi L, Axelrod F, Welsch G, Passino C, Hilz MJ (2004) Sympathetic and
parasympathetic baroreflex dysfunction in Familial Dysautonomia. Neurology, 63:1427-31 (IF 5.97)
112. Dütsch M, Devinsky O, Doyle W, Marthol H, Hilz MJ (2004) Cerebral autoregulation improves in
epilepsy patients after temporal lobe surgery. J Neurol, 251:1190-7 (IF 3.14)
113. Hilz MJ, Werner D, Marthol H, Flachskampf FA, Daniel WG (2004) Enhanced external
counterpulsation improves skin oxygenation and perfusion. Eur J Clin Invest, 34:385-91 (IF 2.53)
114. Hilz MJ, Axelrod F, Bickel A, Stemper B, Brys M, Wendelschafer-Crabb, Kennedy W (2004)
Assessing function and pathology in familial dysautonomia: Assessment of temperature perception,
sweating and cutaneous innervation. Brain, 127:2090-8 (IF 8.2)
115. Marthol H, Werner D, Brown C, Hecht M, Daniel WG, Hilz MJ (2005) Enhanced external counterpulsation does not compromise cerebral autoregulation. Act Neurol Scand, 111:34-41 (IF 1.71)
116. Sanya EO, Brown CM, Wilmowsky C, Neundörfer B, Hilz MJ (2005) Impairment of
parasympathetic baroreflex responses in migraine patients. Acta Neurol Scand, 111:102-7 (IF 1.71)
117. Sanya EO, Tutaj M, Brown CM, Goel N, Neundörfer B, Hilz MJ (2005) Abnormal heart rate and
blood pressure responses to baroreflex stimulation in multiple sclerosis patients. Clin Auton Res,
15:213-18 (IF 0.83)
118. Sanya EO, Tutaj M, Brown CM, Goel N, Neundörfer B, Hilz MJ. (2005) Letter to the Editors.
Response to Flachenecker et al. Abnormal baroreflex responses in Multiple sclerosis. Clin Auton Res,
15:420 (IF 0.83)
119. Tutaj M, Marthol H, Berlin D, Brown CM, Axelrod FB, Hilz MJ (2006) Effect of physical countermanoevers on orthostatic hypotension in Familial Dysautonomia, J Neurol, 253:65-72 (IF 3.14)
120. Berghoff M, Kilo S, Hilz M, Freeman R (2006) Differential impairment of the sudomotor and
nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve, 33:494-499 (IF 2.43)
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
121. Marthol H,Reich S, Jacke J, Lechner K.H., Wichmann M, Stemper B, Hilz MJ (2006) Enhanced
sympathetic cardiac modulation in bruxism patients. Clin Auton Res, 16:276-280 (IF 0.83)
122. Dütsch M, Hilz MJ, Devinsky O (2006) Impaired baroreflex function in temporal lobe epilepsy. J
Neurol, 253:1300-8 (IF 3.14) [Conception and design of Study, Data analysis and interpretation,
drafting or revising critically important intellectual content]
123. Stemper B, Beric A, Welsch G, Haendl T, Sterio D, Hilz MJ (2006) Deep brain stimulation
improves orthostatic regulation of Parkinson patients. Neurology, 67:1781-5.(IF 5.97)
124. Marthol H, Brown CM, Zikeli U, Ziegler D, Dimitrov N, Baltadhzieva R, Hilz MJ (2006) Altered
cerebral regulation in type 2 diabetic patients with cardiac autonomic neuropathy. Diabetologia,
49:2481-7 (IF 5.24)
125. Hilz MJ, Devinsky O, Szczepanska H, Borod J, Marthol H, Tutaj M (2006) Right ventromedial
prefrontal lesions result in paradoxical activation with emotional stimuli. Brain, 129:3343-55 (IF 8.2)
126. Marthol H, Zikeli U, Brown CM, Tutaj M, Hilz MJ (2007) Cardiovascular and cerbrovascular
responses to lower body negative pressure in type 2 diabetic patients. J Neurol Sci, 252:99-105 (IF
2.36)
127. Peters A, Schwarze B, Tomandl B, Probst-Cousin S, Lang C, Hilz M (2007) Bilateral striatal
hyperintensities on diffusion weighted MRI in acute methanol poisoning. Eur J Neurol, 14:e1-2 (IF
2.22)
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Max Hilz
128. Huttner HB, Richter G, Hildebrandt M, Blümcke I, Fritscher T, Brück W, Gärtner J, Seifert F,
Staykov D, Hilz MJ, Schwab S, Bardutzky J (2007) Acute onset of fatal vegetative symptoms: unusual
presentation of adult Alexander disease. Eur J Neurol, 14:1251-5 (IF 2.22) [drafting or revising critically
important intellectual content]
129. Dütsch M, Burger M, Dörfler C, Schwab S, Hilz MJ (2007) Cardiovascular autonomic function in
poststroke patients. Neurology, 69:2249-55 (IF 5.97)
130. Hilz MJ. Peripheral nervous system involvement in Fabry disease: role in morbidity and mortality
(2007) Clin Ther. Suppl A:S11-2. No abstract available. Erratum in: Clin Ther, 29:2268.
131. Stemper B, Devinsky O, Haendl T, Welsch G, Hilz MJ (2008) Effects of vagus nerve stimulation
on cardiovascular regulation in patients with epilepsy. Act Neurol Scand, 117:231-6 (IF 1.71)
132. Kanter IC, Huttner HB, Staykov D, Biermann T, Struffert T, Kerling F, Hilz MJ, Schellinger PD,
Schwab S, Bardutzky J (2008) Cyclophosphamide for anti-GAD antibody-positive refractory status
epilepticus.Epilepsia, 49:914-20 (IF 3.52) [drafting or revising critically important intellectual content]
133. Seifert F, Struffert T, Hildebrandt M, Blümcke I, Brück W, Staykov D, Huttner HB, Hilz MJ,
Schwab S, Bardutzky J (2008) In vivo detection of hepatitis C virus (HCV) RNA in the brain in a case
of encephalitis: evidence for HCV neuroinvasion. Eur J Neurol, 15:214-8 (IF 2.22) [drafting or revising
critically important intellectual content]
134. Brown CM, Marthol H, Zikeli U, Ziegler D, Hilz MJ (2008) A simple deep breathing test reveals
altered cerebral autoregulation in type 2 diabetic patients. Diabetologia, 51:756-61 (IF 5.24)
135. Solaimanzadeh I, Schlegel TT, Feiveson AH, Greco EC, DePalma JL, Starc V, Marthol H, Tutaj
M, Buechner S, Axelrod FB, Hilz MJ (2008) Advanced electrocardiographic predictors of mortality in
Familial Dysautomia. Autonomic Neuroscience: Basic and Clinical, 144:76-82 (IF 1.75)
136. Kiphuth IC, Staykov D, Kohrmann M, Struffert T, Richter G, Bardutzky J, Kollmar R, Maurer M,
Schellinger PD, Hilz MJ, Doerfler A, Schwab S, Huttner HB (2009) Early Administration of Low
Molecular Weight Heparin after Spontaneous Intracerebral Hemorrhage. A Safety Analysis.
Cerebrovasc Dis, 27:146-150.(IF 2.53) [drafting or revising critically important intellectual content]
137. Kerling F, Dütsch M, Linke R, Kuwert T, Stefan H, Hilz MJ (2009) Relation between ictal asystole
and cardiac sympathetic dysfunction shown by MIBG-SPECT Acta Neurol Scand, 120:1213-9 (IF
1.71)
138. Stirban A, Laude D, Elghozi JL, Sander D, Agelink MW, Hilz MJ, Ziegler D (2009) Acute effects
of Sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in Type 2
diabetic patients. Diabetes Metab Res Rev, 25:136-45 (IF 3.37) [drafting or revising critically important
intellectual content]
139. Bickel A, Heyer G, Senger C, Maihoefner C, Heuss D, Hilz MJ, Namer B (2009) C-fiber axon
reflex flare size correlates with epidermal nerve fiber density in human skin biopsies. J Peripher Nerv
Syst, 14:294-9. (IF 2.80) [Data interpretation, drafting or revising critically important intellectual content]
140. Strothotte S, Strigl-Prill N, Grunert B, Kornblum C, Eger K, Wessig C, Deschauer M, Breunig F,
Glocker FX, Vielhaber S, Brejova A, Hilz MJ, Reiners K, Müller-Felber W, Mengel E, Spranger M,
Schoser B (2010) Enzyme replacement therapy with alglucosidase alfa in 44 patients with late-onset
glycogen storage disease type 2: 12-month results of an observational clinical trial. J Neurol, 257:91-7
(IF 3.14) [drafting or revising critically important intellectual content]
141. Axelrod FB, Hilz MJ, Berlin D, Yau PL, Javier D, Sweat V, Bruehl H, Convit A (2010)
Neuroimaging supports central pathology in familial dysautonomia J Neurol, 257:198-206 (IF 3.14)
[Conception and design of Study, Data analysis and interpretation, drafting or revising critically
important intellectual content]
142. Giannini EH, Mehta AB, Hilz MJ, Beck M, Bichet DG, Brady RO, West M, Germain DP, Wanner
C, Waldek S, Clarke JT, Mengel E, Strotmann JM, Warnock DG, Linhart A (2010) A validated disease
severity scoring system for Fabry disease. Mol Genet Metab, 99:283-90. (IF 2.94) [drafting or revising
critically important intellectual content]
143. Cimaz R, Guillaume S, Hilz MJ, Horneff G, Manger B, Thorne JC, Møller AT, Wulffraat NM, Roth
J (2010) Awareness of Fabry disease among rheumatologist – current status and perspectives. Clin
Rheumatol, 30:467-75 (IF. 1.55) [drafting or revising critically important intellectual content]
144. Hilz MJ, Marthol H, Schwab S, Kolodny EH, Brys M, Stemper B (2010) Enzyme replacement
therapy improves cardiovascular responses to orthostatic challenge in Fabry patients. J Hypertens,
28:1438-1448 (IF 5.13)
145. Marthol H, Intravooth T, Bardutzky J, De Fina P, Schwab S, Hilz MJ (2010) Sympathetic
cardiovascular hyperactivity precedes brain death. Clin Auton Res, 20:363-9 (IF 1.51)
146. Kulesh SD, Filina NA, Frantava NM, Zhytko NL, Kastsinevich TM, Kliatskova LA, Shumskas MS,
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Max Hilz
Hilz MJ, Schwab S, Kolominsky-Rabas PL (2010) Incidence and Case-Fatality of Stroke on the East
Border of the European Union. The Grodno Stroke Study. Stroke, 41:2726-30 (IF 7.04) [Data
interpretation, drafting or revising critically important intellectual content]
147. Hilz MJ, DeFina P, Anders S, Koehn J, Lang CJ, Pauli E, Flanagan S, Schwab S, Marthol H
(2011) Frequency analysis reveals subtle cardiac autonomic dysfunction in patients with mild
traumatic brain injury. J Neurotrauma. 28:1727-38 (IF 4.25)
148. Hilz MJ, Moeller S, Akhundova A, Marthol H, Pauli E, DeFina P, Schwab S (2011) High NIHSS
values predict impairmant of cardiovascular autonomic control. Stroke, 42:1528-33 (IF 7.04)
149. Kulesh SD, Kastsinevich TM, Kliatskova LA, Sauchanka ME, Filina NA, Shumskas MS, Schwab
S, Hilz MJ, Kolominsky-Rabas PL (2011) Long-term outcome after stroke in Belarus: The Grodno
Stroke Study. Stroke, 42:3274-6 (IF 7.04) [Data interpretation, drafting or revising critically important
intellectual content]
150. Wagner I, Volbers B, Hilz MJ, Dörfler A, Schwab S, Staykov D (2012) Radiopacity of intracerebral
hemorrhage correlates with perihemorrhagic edema. Eur J Neurol, 19:525-8 (IF 1.16) [Data
interpretation, drafting or revising critically important intellectual content]
151. Hilz MJ, Koehn J, Kolodny Eh, Brys M, Moeller S, Stemper B (2011) Metronomic breathing
shows altered parasympathetic baroreflex function in untreated Fabry patients and baroreflex
improvement after enzyme replacement therapy. J Hypertens, 29:2387-94 (IF 3.98)
152. Üçeyler N, He L, Schönfeld D, Kahn AK, Reiners, K, Hilz, M, Breunig, F, Sommer, C (2011) Small
fibers in Fabry disease: baseline and follow-up data under enzyme replacement therapy. J Peripher
Nerv Syst, 16:304-14 (IF 3.03) [Data interpretation, drafting or revising critically important intellectual
content]
153. Moeller S, Hilz MJ, Blinzler C, Koehn J, Doerfler A, Schwab S, Köhrmann M (2012) Extracranial
Internal Carotid Artery Vasospasm due to Sympathetic Dysfunction. Neurology, 78:1892-4 (IF 8.25)
[Data interpretation, drafting or revising critically important intellectual content]
154. Hilz MJ, Ehmann E, Pauli E, Baltadzhieva R., Koehn J, Moeller S, DeFina P, Axelrod F (2012)
Combined counter-maneuvers accelerate recovery from orthostatic hypotension in Familial
Dysautonomia. Acta Neurol. Scand, 126:162-70 (IF 2.47)
155. Koehn J, Kollmar R, Cimpianu CL, Kallmünzer B, Moeller S, Schwab S, Hilz MJ (2012) Head
and Neck Cooling Decreases Tympanic and Skin Temperature, But Significantly Increases Blood
Pressure. Stroke, 43:2142-8 (IF 6.83)
156. Hilz MJ, Koehn J, Tillmann A, Riss S, Marthol H, Köhrmann M, Wasmeier G, Schwab S,
Stemper B (2013) Autonomic blockade during sinusoidal baroreflex activation proves sympathetic
modulation of cerebral blood flow velocity. Stroke, 44: 1062-9 (IF 6.83)
157. Breuer L, Huttner HB, Kiphuth IC, Ringwald J, Hilz MJ, Schwab S, Köhrmann M (2013) Waiting
for platelet counts causes unsubstantiated delay of thrombolysis therapy. Eur Neurol, 69:317-20 (IF
1.50) [Data interpretation, drafting or revising critically important intellectual content]
158. Hilz MJ, Stadler P, Gryc T, Juliane Nath J, Habib-Romstoeck L, Stemper B, Buechner S, Wong
S, Koehn J (2014) Music induces different cardiac autonomic arousal effects in young and older
persons. Autonomic Neuroscience: Basic and Clinical, 183: 83-93 (IF 1.85)
159. Kallmünzer B, Bobinger T, Kahl N, Kopp M, Kurka N, Hilz MJ, Marquardt L, Schwab S,
Köhrmann M (2014) Peripheral pulse measurement after ischemic stroke: A feasibility study.
Neurology, 83:5 98-603 (IF 8.30) [Data interpretation, drafting or revising critically important intellectual
content]
160. Winder K, Seifert F, Ohnemus T, Sauer EM, Kloska S, Dörfler A, Hilz MJ, Schwab S, Köhrmann
M (2015) Neuroanatomic correlates of poststroke hyperglycemia. Ann Neurol. 2015 Feb;77(2):262-8
(IF 11.91) [Data interpretation, drafting or revising critically important intellectual content]
161. Seifert F, Kallmünzer B, Gutjahr I, Breuer L, Winder K, Kaschka I, Kloska S, Doerfler A, Hilz MJ,
Schwab S, Köhrmann M (2015) Neuroanatomical correlates of severe cardiac arrhythmias in acute
ischemic stroke. J. Neurology, 262:1182-90 [IF 3.841] [Data interpretation, drafting or revising critically
important intellectual content]
162. Bobinger T, Kallmünzer B, Kopp M, Kurka N, Arnold M, Hilz MJ, Hagen B. Huttner HB, Schwab
S, Köhrmann M (2015) Prevalence and impact on outcome of electrocardiographic early
repolarization patterns among stroke patients. A prospective observational study. Clinical Research in
Cardiology, 104:666-71 (IF:4.2) [Data interpretation, drafting or revising critically important intellectual
content]
163. Hilz MJ., Intravooth T, Moeller S, Wang R, Lee DH, Koehn J, Linker RA (2015) Central autonomic
dysfunction delays recovery of Fingolimod induced heart rate slowing. PLoS One, 2015 Jul
6;10(7):e0132139. doi: 10.1371/journal.pone.0132139. eCollection 2015. (IF=3.534) [Data
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Max Hilz
interpretation, drafting or revising critically important intellectual content]
164. Hilz MJ, Aurnhammer F, Flanagan SR, Intravooth T, Wang R, Hösl KM, Pauli E, Koehn J (2015)
Eyeball pressure stimulation unveils subtle autonomic cardiovascular dysfunction in persons with a
history of mild traumatic brain injury. Journal of Neurotrauma, 2015 Sep 23. [Epub ahead of print] [IF
3.714] [Data interpretation, drafting or revising critically important intellectual content]
165. Koehn J, Crodel C, Deutsch M, Kolominsky-Rabas PL, Hösl KM, Köhrmann M, Schwab S, Hilz
MJ (2015) Erectile Dysfunction (ED) after ischemic stroke - association between prevalence and site
of lesion. Clin Auton Res, 2015 Sep 15. [Epub ahead of print] [IF 1.487] [Data interpretation, drafting or
revising critically important intellectual content]
166. Kallmünzer B, Bobinger T, Kopp M, Kurka N, Arnold M, Hilz MJ, Schwab , Köhrmann M (2015)
Impact of heart rate dynamics on mortality in the early phase after ischemic stroke: a prospective
observational trial. J Stroke Cerebrovasc Dis, 24: 946-51 [IF 1.669] [Data interpretation, drafting or
revising critically important intellectual content]
167. Winder K, Seifert F, Koehn J, Deutsch M, Engelhorn T, Dörfler A, Lee D.H., Linker R.A., and Hilz
M.J (2015) Site and Size of Multiple Sclerosis Lesions Predict Enhanced or Decreased Female
Orgasmic Function. [in press] [IF 3.841]
Other Peer Reviewed Publications
168. Neundörfer B, Druschky A, Hilz MJ (1997) Paraneoplastic syndromes of the central and
peripheral nervous system as well as the musculature. Neurology, Psychiatry and Brain Res, 5:15-20
(IF: 0.10) [Conception and design of Study, drafting or revising critically important intellectual content]
169. Heckmann JG, Mück-Weymann M, Hilz MJ, Claus D, Neundörfer B (1997) Die transkranielle
Doppler-sonographie unter Ergometerbelastung: Methodik und Fallbeispiele. Akt Neurol, 24: 9-83 (IF
0.33) [Conception and design of Study, drafting or revising critically important intellectual content]
170. Neundörfer B, Hilz MJ (1998) Ludwig Robert Müller (1870-1962) - a pioneer of autonomic
nervous system research. Clin Auton Res, 8: 1-5 (IF 0.83) [Conception and design of Study, drafting
or revising critically important intellectual content]
171. Hilz MJ, Dütsch M, Neundörfer B (1998) Autonome Störungen bei Polyneuropathien.
Med Klinik, 93:533-40 (IF 0.47)
172. Lang C, Hilz MJ (1998) Neurologische Expertise wünschenswert. Dtsch. Ärzteblatt, 37:A2268A2269 [Conception and design of Study, drafting or revising critically important intellectual content]
173. Hilz MJ, Stemper B (1998) Staging der diabetischen Neuropathie. Nervenheilkunde,17:424-29
(IF 0.45)
174. Hecht M, Hilz MJ. (1998) Neurophysiologische Befunde der diabetischen Neuropathie: Neurographie, Elektromyographie, Vibratometrie, Thermotestung. Nervenheilkunde, 17:430-36 (IF 0.45)
[Conception and design of Study, drafting or revising critically important intellectual content]
175. Stemper B, Hilz MJ (1998) Autonome diabetische Neuropathie: kardiale und peripher-autonome
Befunde. Nervenheilkunde, 17:437-43 (IF 0.45) [Conception and design of Study, drafting or revising
critically important intellectual content]
176. Zahner B, Hilz MJ (1998) Abgrenzung des Karpaltunnelsyndroms gegenüber der
Polyneuropathie bei Diabetes mellitus. Nervenheilkunde, 17:444-51 (IF 0.45) [Conception and design
of Study, drafting or revising critically important intellectual content]
177. Zahner B, Hilz MJ (1998) Therapiemöglichkeiten der diabetischen Polyneuropathie - ein
Ausblick.
Nervenheilkunde, 17:452-57 (IF 0.45) [Conception and design of Study, drafting or revising critically
important intellectual content]
178. Heckmann JG, Hilz MJ, Brandt-Pohlmann M, Hecht M, Neundörfer B (1998) Aktueller Stand der
Diagnostik des offenen Foramen ovale. Nervenheilkunde, 17:458-60 (IF 0.45) [Conception and design
of Study, drafting or revising critically important intellectual content]
179. Hilz MJ, Dütsch M, Kölsch C (1999) Epilepsie und autonome Störungen. Fortschr Neurol
Psychiat, 67:49-59
(IF 0.75)
180. Neundörfer B, Hilz MJ (1999) Störungen des autonomen Nervensystems. Akt Neurol, 26:49-54
(IF 0.33) [Conception and design of Study, drafting or revising critically important intellectual content]
181. Hilz MJ (1999) Neurodiagnostic procedures used in the diagnosis of erectile dysfunction.
Clin Auton Res, 9:291-93 (IF 0.83)
182. Hecht M, Hilz MJ, Neundörfer B (2000) Somatosensibel evozierte Potentiale nach Stimulation
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Max Hilz
des N. trigeminus in der Diagnostik von Hirnstammläsionen. Nervenheilkunde, 19:247-51 (IF 0.45)
[Conception and design of Study, drafting or revising critically important intellectual content]
183. Hecht M, Hilz MJ (2000) Differenzierung von Verschlüssen der Arteria carotis interna gegenüber
Pseudookklusionen – Sind sonographische Methoden ausreichend, um einen Verschluß sicher zu
diagnostizieren? Nervenheilkunde, 19:220-25 (IF 0.45) [Conception and design of Study, drafting or
revising critically important intellectual content]
184. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (2000) Funktionelle transkranielle
Dopplersonographie. Nervenheilkunde, 19:242-46 (IF 0.45) [Conception and design of Study, drafting
or revising critically important intellectual content]
185. Hilz MJ, Kölsch C, Marthol H, Neundörfer B (2000) Engpaßsyndrome der oberen Extremitäten.
Nervenheilkunde, 19:226-36 (IF 0.45)
186. Horn S, Hilz MJ (2000) Sympathische Hautantwort - Ableitetechnik und Befundinterpretation.
Nervenheilkunde, 19: 264-70 (IF 0.45) [Conception and design of Study, drafting or revising critically
important intellectual content]
187. Bickel A, Hilz MJ (2000) Der quantitative Sudomotor-Axonreflextest. Nervenheilkunde, 19:259-63
(IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content]
188. Hilz MJ, Stemper B, Neundörfer B (2000) Physiologie und Untersuchungsmethoden des
Baroreflexes. Fortschr Neurol Psychiat, 68:37-47 (IF 0.75)
189. Hilz MJ, Hecht M, Kölsch C (2000) Erektile Dysfunktion. Akt Neurol, 27:1-12 (IF 0.33)
190. Erxleben H, Hilz MJ (2000) Neurophysiologische Hirnstammdiagnostik mittels Blinkreflex,
Masseterreflex und Kieferöffnungsreflex. Nervenheilkunde, 19:252-58. (IF 0.45) [Conception and
design of Study, drafting or revising critically important intellectual content]
191. Neundörfer B, Hilz MJ (2000) Engpaßsyndrome der unteren Extremitäten.
Nervenheilkunde,19:247-51. (IF 0.45) [Conception and design of Study, drafting or revising critically
important intellectual content]
192. Hilz MJ (2000) Praxisrelevante Fortbildung - ein Bindeglied zwischen Kliniken und
niedergelassnen Nervenärzten. Editorial, Nervenheilkunde, 19: 217 (IF 0.45)
193. Hilz MJ, Marthol H, Neundörfer B (2000) Diabetische somatische Polyneuropathie Pathogenese, klinische Manifestationsformen u:Therapie-Konzepte. Fortschr Neurol Psychiat,
68:278-85 (IF 0.75)
194. Hilz MJ, Stemper B, Heckmann JG, Neundörfer B (2000) Mechanismen der zerebralen
Autoregulation, Untersuchungsverfahren und Beurteilung mittels transkranieller Dopplersonographie.
Fortschr Neurol Psychiat, 68:398-412 (IF 0.75)
195. Heckmann JG, Erbguth FJ, Hilz MJ, Lang CJG, Neundörfer B (2001) Die Hirndurchblutung aus
klinischer Sicht. Historischer Überblick, Physiologie, Pathophysiologie, diagnostische und
therapeutische Aspekte. Med Klin, 96:583-92 (IF 0.47) [Conception& design of Study, revising critically
important intellectual content]
196. Hecht MJ, Bickel A, Neundörfer B, Hilz MJ (2001) Elektrophysiologische Diagnostik des GuillainBarré-Syndroms und der chronisch-imflammatorischen demyelinisierten Polyneuropathie.
Nervenheilkunde, 20:486-90 (IF 0.45) [Conception and design of Study, drafting or revising critically
important intellectual content]
197. Bickel A, Neundörfer B, Hecht MJ, Hilz MJ (2001) Die multifokal-motorische Neuropathie.
Nervenheilkunde, 20:491-98 (IF 0.45) [Conception and design of Study, drafting or revising critically
important intellectual content]
198. Dütsch M, Hilz MJ, Neundörfer B (2001) Klinik und Diagnose der diabetischen autonomen
Neuropathie. Fortschr Neurol Psychiat, 69:423-38 (IF 0.75) [Conception and design of Study, drafting
or revising critically important intellectual content]
199. Hilz MJ (2002) Erektile Dysfunktion. Münchener Medizinische Wochenschrift, 7:41-44
200. Hilz MJ (2002) Assessment and evaluation of hereditary sensory and autonomic neuropathies
with autonomic and neurophysiological examinations. Clin Auton Res, 12, Suppl. 1:I/33-I/43 (IF 0.83)
201. Hilz MJ, Marthol H, Neundörfer B (2002) Synkopen – eine systematische Übersicht zur Klassifikation, Pathogenese, Diagnostik und Therapie. Fortschr Neurol Psychiat, 70:95-107 (IF 0.75)
202. Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K,
Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O’Connor DT, Peltzer SR, Robert-son
D, Rubin BY, Scudder Q, Smith LJ, Sonenshein GE, Svetjstrup, Xu Y, Slaugenhaupt SA (2003)
Hereditary dysautonomias: current knowledge and collaborations for the future. Clin Auton Res,
13:180-95 (IF 0.83) [Conception and design of Study, drafting or revising critically important intellectual
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Max Hilz
content]
203. Hilz MJ. Marthol H (2003) Erektile Dysfunktion - Wertigkeit neurophysiologischer
Diagnoseverfahren. Der Urologe, 10:1345-50 (IF: 0.44)
204. Marthol H, Hilz MJ (2004) Weibliche sexuelle Funktionsstörungen. Weibliche sexuelle Funktionsstörungen: Klassifikation, Diagnostik und Therapie. Fortschr Neurol Psychiatr, 72:121-35 (IF 0.75)
[Conception and design of Study, drafting or revising critically important intellectual content]
205. Hilz MJ, Dütsch M (2005) Methoden zur quantitativen Untersuchung des autonomen
Nervensystems. Der Nervenarzt, 76:767-78 (IF 0.89)
206. Hilz MJ, Dütsch M (2006) Quantitative studies of autonomic function. Muscle Nerve (invited
review article) Muscle Nerve, 33:6-20 (IF 2.43)
207. Hilz MJ (2007). Peripheral nervous system involvement in Fabry disease: Role in morbidity and
mortality.
Clin Ther, 29:11-2 (IF 2.89)
208. Kohl B, Hülsemann W, Habenicht R, Hilz MJ, Stemper B, Püst B (2007) Hereditary sensory
neuropathy type IV. Two case reports, Monatsschrift für Kinderheilkunde, 155:281-286 (IF: 0.23)
[Conception and design of Study, drafting or revising critically important intellectual content]
209. Schaefer R, Szymanska AT, Hilz MJ (2009) Enzyme replacement therapy for Fabry disease: A
systematic review of available evidence, Drugs, 69: 2179-205 (IF: 4.12) [Conception and design of
Study, drafting or revising critically important intellectual content]
210. Dütsch M, Hilz MJ (2010) Neurological complications in Fabry Disease. Rev Med Interne,
31:243-250 [Conception and design of Study, drafting or revising critically important intellectual
content]
211. Lahrmann H, Rocha I, Struhal W, Thijs RD, Hilz MJ (2011) Diagnosing autonomic nervous
system disorders – existing guidelines and future perspectives. European Neurological Review, 6: 526 [Conception and design of Study, drafting or revising critically important intellectual content]
212. Burlina AP, Sims KB, Politei JM, Bennett GJ, Baron R, Sommer C, Møller AT, Hilz MJ (2011)
Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of
neuropathic pain: the report of an expert panel. BMC Neurology, 11:61 (IF 2.56) [Conception and
design of Study, drafting or revising critically important intellectual content]
213. Sommer C, Üçeyler N, Thomas Duning T., Arning K, Baron R, Brand E, Canaan-Kühn S, Hilz
MJ, Naleschinski D, Wanner C, Weidemann F. (2012) Pain Therapy in Fabry’s disease Schmerztherapie bei Morbus Fabry. Internist (Berl), 54:121-2, 124-30. [Conception and design of
Study, drafting or revising critically important intellectual content]
214. Kolodny E, Fellgiebel A, Hilz MJ, Sims K, Caruso P, Phan TG, Politei J, Manara R, Burlina A.
(2015) Cerebrovascular Involvement in Fabry Disease: Current Status of Knowledge. Stroke, 46:302313 (IF 6.018) [Conception and design of Study, drafting or revising critically important intellectual
content]
215. Maier A, Mannartz V, Wasmuth H, Trautwein Christian, Neumann UP, Weis J, Grosse J, Fuest
M, Hilz MJ, Schulz JB, Haubrich C (2015) GAD Antibodies as Key-link between Chronic Intestinal
Pseudoobstruction, Autonomic neuropathy, and Limb Stiffness in a Non-diabetic patient. Medicine.
(accepted) (IF=5.723)
216. Hilz Max, Hoppe Ulrich, Möller Sebastian, Wang Ruihao, Köhn Julia (2015) Can stapedius-reflex
testing objectively measure muscle function in Pompe patients? Clinical Case Reports. (accepted)
Invited Contributions
217. Cleeland CS, Hilz MJ (2002) Editorial Commentary. Acta Pediatr, 91(Suppl):33 (IF 1.14)
[Conception and design of Study, drafting or revising critically important intellectual content]
218. Hilz MJ (2002) Evaluation of peripheral and autonomic nerve function in Fabry disease.
Acta Pediatr (invited review), 91(Suppl):38-42 (IF 1.14)
219. Axelrod F, Hilz MJ (2003) Inherited autonomic neuropathies. Semin Neurol, 4:381-90 (IF 1.04)
[Conception and design of Study, drafting or revising critically important intellectual content]
220. Lahrmann H, Cortelli P, Hilz MJ, Mathias C, Struhal W, Tassinari M (2006) EFNS Task Force
EFNS guidelines on the diagnosis and management of orthostatic hypotension. Eur J Neurol, 13:9306 (IF 2.22) [Conception and design of Study, drafting or revising critically important intellectual content]
221. Hilz MJ, Schwab S (2008) Stroke induced sudden-autonomic death: areas of fatality beyond the
insula. (Editorial) Stroke, 39:2421-2 (IF 6.29)
222. D. Ziegler D, Haslbeck M, Neundörfer B, Luft D, Bierwirth R, Forst T, Hilz M, Jacob S, Keller J,
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Max Hilz
Lobmann R, Pannek J (2010) Diabetische Neuropathie, S1 Leitlinie der Deutschen Diabetes
Gesellschaft Diabetologie 5: S1–S10. [Conception and design of Study, drafting or revising critically
important intellectual content]
223. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP,
Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H,
Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schondorff R,
Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension,
neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci, 161:46-8 (IF1.67)
[Conception and design of Study, drafting or revising critically important intellectual content]
224. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP,
Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H,
Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schondorff R,
Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension,
neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res, 21:69-72 (IF
1.27) [Conception and design of Study, drafting or revising critically important intellectual content]
225. Hilz MJ (2012) Autonome Komplikation nach Schaganfall. Neurologisch 1/12:88-89
226. Hilz MJ, Hoppe Ulrich, Moeller S, Wang R and Koehn J (2015) Can stapedius reflex testing
objectively measure muscle function in Pompe patients? Clinical Case Reports, doi: 10.1002/ccr3.400
MEDIA RESOURCE EDUCATIONAL MATERIALS
Hilz, MJ. Autonomic Neurology. in M.A. Samuels (ed.): "Comprehensive Review of Neurology"
Oakstone Medical Publishing, 30 Audio CDs; 08, 31, 2009
Book Chapters
1. Druschky KF, Pfurtscheller G, Hilz MJ, Wack P, Neundörfer B, Litscher G, Brinkmann HG (1988)
Multimodale elektrophysiologische Komaskala (MECS) als prognostisches Kriterium bei Hirnstammprozessen. In: Bogdahn U, Mertens HG, eds. Prognostik in der Intensivtherapie des Zentralnervensystems. Berlin-New York: Springer, 290-6
2. Hilz MJ, Druschky KF, Huk W, Brinkmann H (1988) Zieve-Syndrome - a risk factor in the
pathogenesis of intra-cranial hemorrhages? In: Bartko D, ed. Modern Trends in Neurology &
Neurological Emergencies. Prag, 217-8
3. Hilz MJ, Höll R, Weidenhammer W, Mösler TA, Lungershausen E (1989) Attitudes of medical staffs
towards suicide patients. In: Stefanis CN, Soldatos CR, Rabavilas AD, eds. Psychiatry today,
Accomplishments and promises, VIII World Congress of Psychiatry. Amsterdam: Elsevier, 106
4. Hilz MJ, Schellmann B, Sörgel F (1989) Fatal Complications after Intrathecal Application of
Megluminamidotrizoat. In: Proceedings of the Second Meeting of the International Neurotoxicology
Association. Barcelona: Graficas Campas, 252
5. Hilz MJ, Druschky KF, Höll R, Wagner S, Ostermann N, Weidenhammer W (1991 Komaskalen im
Vergleich. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte
neurologischer Intensivmedizin, Bd. 19, Erlangen: Perimed, 112-7
6. Hilz, MJ, Druschky KF, Weis M, Litscher G, Pfurtscheller G, Neundörfer B (1991) Kontinuierliches
multiparametrisches Neuromonitoring - Erste Erfahrungen. In: Druschky KF, Erbguth F, Neundörfer B,
eds. Notfallmedizin, Schwerpunkte neurolog. Intensivmedizin, Bd 19, Erlangen: Perimed, 124-8
7. Hilz MJ, Rudel H, Druschky KF (1991) Dekubitustherapie mit einem Air-Fluidized-Bett bei einem
Patienten mit Hypercortisolismus und chronsich idiopathischer Polyneuroradikulitis. In: Druschky KF,
Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurol. Intensivmedizin, Bd 19,
Erlangen: Perimed, 162-5
8. Hilz MJ, Claus D, Rösl G, Neundörfer B, Sterzel RB (1991) Einfluß der Hämodialyse auf Temperatur- und Vibratometrieschwellen bei chronisch terminaler Niereninsuffizienz. In: Firnhaber W,
Dworschak K, Lauer K, Nichtweiß M, eds. Verhandlungen der DGN, Bd 6, Berlin: Springer, 638-9
9. Brinkmann HG, Bauer J, Druschky KF, Erbguth F, Hilz MJ, Stefan H (1991) Protrahierter Status
epilepticus komplex-partieller Anfälle. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin,
Schwerpunkte neurologischer Intensivmedizin, Bd. 19, Erlangen: Perimed, 97-9
10. Erbguth F, Hilz MJ, Druschky KF, Neundörfer B (1991) Bilaterale Infarzierungen von Thalamus
und Stammganglien bei Thrombosen der inneren Hirnvenen. In: Druschky KF, Erbguth F, Neundörfer
B, eds. Notfallmedizin, Schwerpunkte neurol. Intensivmedizin, Bd. 19, Erlangen: Perimed, 189-93
11. Erbguth F, Hilz MJ, Rechlin T, Weis M, Claus D (1991) Diagnostische und therapeutische
Probleme bei Listerien-Meningoenzephalitiden. In: Huffmann G, Braune W, eds. Infektionskrankheiten
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Max Hilz
des Nervensystems, Reinbeck: Einhorn, 223-32
12. Höll R, Hilz MJ, Druschky KF, Brinkmann HG, Grahmann F, Stefan H, Neundörfer B (1991)
Status myoclonicus bei einem Patienten mit einer nicht klassifizierbaren progressiven
Myoklonusepilepsie. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwer-punkte
neurologischer Intensivmedizin, Notfallmedizin, Band 19, Erlangen: Perimed, 104-6
13. Litscher G, Schwarz G, Pfurtscheller G, Hilz MJ, Lechner A, List WF (1991) Neuromonitoring in
critical care medicine. In: Proceedings of the Internat. Munich Symposium on advanced Critical Care
Monitoring, E17.1-2
14. Hilz MJ, Claus D, Neundörfer B (1992) "Marstock"-Thermotestung - eine Bereicherung in der
Diagnostik von Polyneuropathien. In: Huffmann G, Braune HJ, eds. Läsionen des peripheren
Nervensystems. Reinbeck: Einhorn, 115-21
15. Zahner B, Stefan H, Feistel H, Hilz MJ, Harrer M, Neundörfer B (1992) Verlaufsuntersuchungen
zur akuten bakteriellen Meningitis/ Meningoencephalitis. In: Schimrigk K, Haaß A, Hamann G, eds.
Verhandlungen der Dtsch. Ges. f. Neurologie. Vol. 7, Zweibrücken: Conrad & Bothner, 602-4
16. Hilz MJ, Erbguth F, Weis M, Faatz U, Claus D, Neundörfer B (1992) Wertigkeit von Koma-Skalen
für eine frühe Beurteilung der Prognose. In: Schimrigk K, Haaß A, Hamann G eds. Verhandlungen der
Dtsch. Ges. für Neurologie. Vol. 7, Zweibrücken: Conrad & Bothner, 545-7
17. Erbguth F, Friedel A, Hilz MJ, Kilian KD, Rechlin T, Claus D, Neundörfer B (1992) Botulinus-ToxinInjektionen bei zervikalen Dystonien: Probleme der Therapiekontrolle bei Verlaufs-untersuchungen. In:
Schimrigk K, Haaß A, Hamann G, eds. Verhandlungen der DGN. Vol. 7, Zweibrücken: Conrad &
Bothner, 111-3
18. Neundörfer B, Hilz MJ (1994) Die Bedeutung von Anamnese und klinisch-neurologischem Untersuchungsbefund für das Neuromonitoring in Anästhesie und Intensivtherapie. In: Rügheimer E, Dinkel
M, eds. Neuromonitoring in Anästhesie und Intensivmedizin, Berlin: Springer, 43-51
19. Hilz MJ, Neuner I, Glorius S, Schweibold G, Axelrod F, Kolodny EH (1995) Quantitative Thermotestung als Indikator kardialer autonomer Gefährdung bei Familiärer Dysautonomie. In: Jerusalem F,
Ries F, eds. Verhandlungen der DGN. Vol. 8, Bonn, Köllen Druck & Verlag, 475-7
20. Hilz MJ (1997) Autonome Störungen bei Polyneuropathien. In: Diener HC, Felgenhauer K,
Reichmann H, Wallesch CW, Wiegand F, eds. Akt. Neurol, Sonderband. DGN ´97, Stuttgart, Thieme,
E5-1 - 10
21. Heckmann JG, Mück-Weymann M, Hilz MJ, Claus D, Neundörfer B (1998) Transcranial Doppler
sonography under ergometer stress suggests diminished sympathetic cerebrovascular activity in
tension type headache. In: Blazek V, Schulz-Ehrenburg U, eds. Frontiers in computer-aided
visualization of vascular functions. VDI-Verlag, Düsseldorf, 165-8
22. Hilz MJ (1998) Testing of peripheral and vascular autonomic function. In: Stalberg EV, DeWeerd
AW, Zidar J, eds.9th European Congress of Clin. Neurophysiology, Monduzzi Editore Bologna; 165-72
23. Hilz MJ (1998) Erektile Dysfunktion. In: Brandt, Th, Diener HC, Felgenhauer K, Wallesch CW,
Wiegand F, eds: Akt Neurol, Sonderband. DGN ´98, Thieme Stuttgart, I51-8
24. Heckmann JG, Mück-Weymann M, Hilz MJ, Katalinic A, Neundörfer B (1999) Autoregulative
response of cerebral vessels to elevation in arterial blood pressure: a study using stress TCD. In:
Blazek V, Schulz-Ehren-burg U, eds. Frontiers in computer-aided visualization of vascular functions.
VDI-Verlag, Düsseldorf, 109-12
25. Heckmann JG, Hilz MJ, Russo H, Hagler A, Mück-Weymann M, Neundörfer B (1999) Transcranial
Doppler Sonography during acute 80 degree Head-Down Tilt (HDT) for the Assessment of Cerebral
Autoregulation in Humans. In: Blazek V, Schulz-Ehrenburg U, eds. Frontiers in computer-aided
visualization of vascular functions. VDI-Verlag, Düsseldorf, 105-8
26. Hilz MJ (1999) Neurologische und neurophysiologische Aspekte der erektilen Dysfunktion.
In: Wallesch CW, Diener HC, Felgenhauer K, Wiegand F, eds: Akt Neurol, Sonderband. Dtsch. Ges.
für Neurologie ´99, Thieme Stuttgart, C3-1 –10
27. Dütsch M, Hilz MJ, Rauhut U, Neundörfer B, Axelrod FB (2000) Baroreflex dysfunction contributes
to the occurence of orthostatic hypotension in familial dysautonomia. In: Haupt WF, Grond M, Halber
M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der Arbeitsgemeinschaft Neurologische
Intensivmedizin (ANIM). Shaker, Aachen, 74-5
28. Hecht M, Hilz MJ, Kiesewetter F, Neundörfer B (2000) Verbesserte ätiologische Zuordnung der
erektilen Dysfunktion bei Diabetikern durch neurologisch-neurophysiologische Untersuchung.
In: Haupt WF, Grond M, Halber M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der
Arbeitsgemeinschaft Neurologische Intensivmedizin (ANIM). Shaker, Aachen, 74
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Max Hilz
29. Singer W, McPhee BR, Opfer-Gehrking TL, Hilz MJ, Low PA (2000) Orale Pyridostigmin-Gabe eine neue Strategie in der Behandlung der orthostatischen Hypotonie. In: Haupt WF, Grond M, Halber
M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der Arbeitsgemeinschaft Neurologische
Intensivmedizin (ANIM). Shaker, Aachen, 76
30. Hilz MJ (2001) Synkopen, Klassifikation, Pathogenese und Diagnose. In: Noth J, Diener HC,
Felgenhauer K., Wallesch CW, Busch E, eds.: Akt Neurol. 1998, Sonderband. Dtsch. Ges. für
Neurologie 2001. Thieme Stuttgart; 349-52
31. Heckmann JG, Heckmann SM, Hummel T, Popp M, Marthol H, Neundörfer B, Hilz MJ (2001) Oral
mucosa blood flow following dry ice stimulation in humans. In: Blazek V, Schulz-Ehrenburg U,
Stvrtinová V (eds.): Proceedings, 9th Intern. Symposium CNVD. Wissenschaftsverlag Mainz, Aachen,
135-8
32. Dütsch M., Hilz MJ (2004) Pathophysiologie und Diagnose der Schmerzsymptome bei M. Fabry.
In: Wanner C, ed: Morbus Fabry: Klinik, Diagnostik & Therapie, UNI-MED Verlag, Bremen, 50-60
33. Hilz MJ (2005) Klinische Symptome zentraler und peripherer autonomer Störungen am Beispiel
der diabetischen autonomen Neuropathie und des GBS. Fortbildungsakademie der 78. Jahrestagung
der Deutschen Gesellschaft für Neurologie. Hrsg. Oertel WH, Diener HC, Busch E. Akt Neurol,
Sonderband Dtsch. Ges. für Neurologie, Thieme Stuttgart, 582-583
34. Hilz, MJ (2006) Basic principles of autonomic nervous function together with a classification of key
autonomic disorders and clinical features of dysautonomia; Syllabus, Teaching Course 9: Disorders
affecting the autonomic nervous system - clinical evaluation, investigation and treatment.
http.//www.efns.org/content.php?pid=169#ans, 1-25
35. Hilz MJ (2006) Klinische und apparative Untersuchung autonomer Störungen bei Diabetes.
Fortbildungsakademie der 79. Jahrestagung der Deutschen Gesellschaft für Neurologie. Hrsg.
Hennerici MG, Weiller C, Diener HC, Busch E. Akt Neurol, Sonderband Dtsch. Ges. für Neurologie,
Thieme Stuttgart 226-229
36. Hilz MJ (2007) Diagnostik und Therapie autonomer Störungen. In: Einhäupl KM, Weiller C, Diener
HC, Busch EW, eds.: Akt Neurologie 2007, Sonderband. Dtsch. Ges. für Neurologie, Thieme
Stuttgart; 91-94
37. Hilz MJ, Marthol H (2008) Physiologic changes of autonomic nervous system function during
sleep. Sonderband Dtsch. Ges. für Neurologie Thieme Stuttgart 593-597
38. Hilz MJ, Marthol H (2008) Autonomic Disorders in Guillain-Barré Syndrome and Diabetic
Neuropathy: Pathophysiology, Clinical Relevance and Management. EFNS 2008; Autonomic
disorders in neurology: diagnosis and management
39. Hilz MJ (2013). Autonomic Nervous System. In: Runehov, Anne; Oviedo, Lluis, eds.: Encyclopedia
of Sciences and Religions, Springer; Springer Netherlands. pp 180-182
Handbook chapters:
40. Hilz MJ (1996) Läsionen des Plexus brachialis und des Plexus lumbosacralis. In: Neundörfer B,
Schneider E, Dittmann V, Pöldinger W,eds. Atlas der Nervenheilkunde, G. Braun, Karlsruhe, 86-92
41. Hilz MJ (1999) Autonome Störungen. In: Kukowski B., Hrsg: Differentialdiagnose neurologischer
Symptome. Tabellen und Übersichten für eine schnelle und sichere Diagnosestellung. Thieme,
Stuttgart New York, 348-68
42. Axelrod FB, Hilz MJ (2000) Familial dysautonomia. In: Vinken PJ, Bruyn GW, eds. Handbook of
Clinical Neurology. Elsevier, Amsterdam, The Netherlands, Volume 75 (31), 143-60
43. Hilz MJ (2000) Erectile dysfunction – diagnostic approach and treatment options. In: Ambler Z,
Nevšímalová S, Kadaňka Z, Rossini PM. eds.: Clinical Neurophysiology at the Beginning of the 21st
Century, Elsevier Amsterdam, Lausanne, 234-6
44. Hilz MJ (2001) Alteraciones del sistema nervioso autónomo. In: Kukowski B., Hrsg: Tablas y
resúmes sinópticos para un diagnóstico rápido y seguro. Masson S.A. Barcelona, 361-82
45. Hilz MJ (2002) Quantitative autonomic functional testing in clinical trials. In: Brown WF, Bolton CF,
Aminoff MJ, eds.: Neuromuscular Function and Disease. Basic, clinical and electrodiagnostic aspects.
WB Saunders, Philadelphia, USA, Volume 2; 1899-929
46. Hilz MJ, Stemper B, Koeppen S, Diehl RR (2002) Neurogene Synkopen. Leitlinien für Diagnostik
und Therapie in der Neurologie. In Diener HC, Hrsg: Leitlinien der Dtsch. Ges. für Neurologie, Thieme,
Stuttgart, 276-77
47. Axelrod FB, Hilz MJ (2004) Familial Dysautonomia. In: Robertson D, Low PA, Polinsky RJ, eds.:
Primer on the Autonomic Nervous System, 2nd Ed., Academic Press San Diego, New York, 312-15.
48. Hilz MJ, Ziemssen T (2005) Autonome Störungen. In: Wallesch CW (Hrsg): Neurologie –
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Max Hilz
Diagnostik und Therapie in Klinik und Praxis, Urban & Fischer, München, Jena 327-38.
49. Sander D, Hilz MJ, Ziemssen T (2008) Autonome Störungen und vegetative Krisen. In: Schwab S,
Unterberg A, Werner, Hacke W, Neurologische Intensivmedizin. Springer, Heidelberg 642-660.
50. Jost W, Braune S, Derouet H, Kessler TM, Kiss G, Haensch CA, Hilz MJ. (2008) Diagnostik und
Therapie der erektilen Dysfunktion. In: Diener HC, Putzki N. (ed): Leitlinien für Diagnostik und
Therapie in der Neurologie (Guidelines for diagnostic and therapy in neurology. Thieme, Stuttgart 4.
Auflage.
51. Berlit P., Diehl R.R., Hilz M.J., Schuchert A., Steinhoff B., Herbst H., Humm A., Wenning G. K.
(2008) Synkopen. In:Diener H.C., Putzki N. editors., Leitlinien für die Diagnostik und Therapie in der
Neurologie. Thieme, Stuttgart 4. Auflage.
52. Low PA, Hilz MJ (2008). Diabetic Autonomic Neuropathy. In Low PA., Benarroch EE, eds.: Clinical
Autonomic Disorders, Third Edition. Lippincott Williams & Wilkins, Philadelphia, 423-440
53. Hilz MJ (2008) . Female and Male Sexual Dysfunction. In Low PA., Benarroch EE, eds.: Clinical
Autonomic Disorders, Third Edition. Lippincott Williams & Wilkins, Philadelphia , 657-711
54. Lahrmann H, Cortelli P, Hilz M, Mathias CJ, Struhal W, Tassinari M (2011) EFNS guidelines on the
diagnosis and management of orthostatic hypotension. In: NE Gilhus, M Barnes, M. Brainin:
European Handbook of Neurological Management, Vol 1. sec. ed., 469-475
55. Hilz MJ (2012). Physiology and Pathophysiolgy of female sexual function. In Robertson D,
Biaggioni I, Burnstock G, Low PA, Paton JFR, eds. Primer of the Autonomic Nervous System,
Academic Press, Oxford, 235-238
56. Dütsch M, Hilz MJ (2012). Epilepsy and autonomic control. In Robertson D, Biaggioni I, Burnstock
G, Low PA, Paton JFR, eds. Primer of the Autonomic Nervous System, 3rd Ed. Academic Press,
Oxford, 549-552
57. Jost W, Braune S, Derouet H, Kessler TM, Kiss G, Haensch CA, Hilz MJ (2012). Diagnostik und
Therapie der erektilen Dysfunktion. In: Diener HC, Putzki N. (ed): Leitlinien für Diagnostik und
Therapie in der Neurologie (Guidelines for diagnostic and therapy in neurology. Thieme, Stuttgart 5.
Auflage.
58. Sander D, Hilz MJ, Ziemssen T (2015) Autonome Störungen und vegetative Krisen. In: Schwab S,
Unterberg A, Werner, Hacke W (eds.): Neurologische Intensivmedizin. 2nd ed. Springer, Heidelberg;
(in print).
59. Hilz MJ. (2015) Synkopen. In: Hacke W, Bendszus M., Ringleb P, Schwab S., Wick W (eds.):
Lehrbuch der Neurologie, 14th ed.. Springer, Heidelberg, (in print)
Non-Peer Reviewed Publications
1. Hilz MJ (1987) Schizoaffektive Psychosen und ihre Stellung in der Systematik psychiatrischer
Krankheitsbilder. Nervenheilkunde, 6:164-70 (IF 0.45)
2. Bauer J, Müller RL, Hilz MJ, Stefan H (1989) Flugreisefähigkeit, Schutzimpfungen und
Malariaprophylaxe bei Patienten mit Epilepsie. Epilepsie-Blätter, 2:13-17 [Conception and design of
Study, drafting or revising critically important intellectual content]
3. Hilz MJ (1991) Arbeitstagung der Deutschen Gesellschaft für Neurologie (zusammenfassender
Bericht). Akt Neurol; 18: XXV-XXIX. (IF 0.33)
4. Bauer J, Hilz MJ, Sappke U, Stefan H (1992) Klinische Symptomatologie und Therapie der Status
epileptici. Fortschr Neurol Psychiat, 60:181-205 (IF 0.75) [Conception and design of Study, drafting or
revising critically important intellectual content]
5. Claus D, Spitzer A, Hilz MJ (1992) Diagnose der peripheren diabetischen Polyneuropathie.
Diabetes und Stoffwechsel, 1:34-41 [Conception and design of Study, drafting or revising critically
important intellectual content]
6. Hilz MJ (1992) Exotoxische, metabolisch-toxische und hereditäre Polyneuropathien.
Therapiewoche, 42:2896-904
7. Hilz MJ, Stefan H (1993) Klinisch-neurologische Untersuchung komatöser und
bewußtseinsgetrübter Patienten. Therapiewoche, 43:16-21
8. Zahner B, Hilz MJ, Stefan H (1993) Akute Meningitis und Meningoenzephalitis, Diagnostik und
Therapie. Therapiewoche, 43:33-37 [Conception and design of Study, drafting or revising critically
important intellectual content]
9. Erbguth F, Stefan H, Hilz MJ (1993) Gerinnungshemmende Therapie bei Hirngefäßerkrankungen;
Blutungsgefahr oder Prognoseverbesserung? Therapiewoche, 43:22-27[Conception and design of
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Max Hilz
Study, drafting or revising critically important intellectual content]
10. Hecht M, Hilz MJ (1999) Anatomie und Physiologie der Erektion – Pharmakotherapeutische
Aspekte der erektilen Dysfunktion. EEG-Labor, 20:111-18 [Conception and design of Study, drafting or
revising critically important intellectual content]
11. Hilz MJ (2000) Zusammenfassende Übersicht zu: Kardiosomatische Kopplung als differentieller
Indikator für Komatiefe und Effektivität sensorischer Stimulation. (Hildebrandt H. Zieger A, Engel A,
Kraft A.; Akt. Neurologie 1999: 26; 171-179); Review in Neurol. Intensivmed. Aktuell. 3. Jg., 1;34-36
12. Hilz MJ (2001) Eight years of professional experience with familial dysautonomia. Dyscourse,
Spring /Summer
13. Dütsch M, Hilz MJ, Neundörfer B (2001) Autonome Neuropathie: Symptome, Diagnose und
Behandlung. Der Bayerische Internist, 21:275-84 [Conception and design of Study, drafting or revising
critically important intellectual content]
14. Hilz MJ (2002) Sexual Dysfunction: Diagnosis and Treatment. Neurol Croat, 51(Suppl 1):47-51
15. Dütsch M, Hilz MJ (2002) Diabetes Mellitus – die neurologische Sicht – Behandlung der
Autonomen Polyneuropathie. Der Neurologe und Psychiater, 7-8;48-52 [Conception and design of
Study, drafting or revising critically important intellectual content]
16. Hilz MJ. (2002) Erektile Dysfunktion nach Querschnittslähmung. Uro-News
17. Hecht M, Heuss D, Hilz MJ (2003) Diagnosis and treatment of polyneuropathy: what can the
family doctor do? MMW Fortschr Med.145: Suppl 2:81-85. German. [Conception and design of Study,
drafting or revising critically important intellectual content]
18. Hilz MJ (2003) International activities & symposia on clinical autonomic research. ANS News, 7:79
19. Marthol H, Hilz MJ, Dütsch M, Ziegler D (2007) Klinik, Diagnostik und therapie der autonomen
Therapien - Klinische Symptomatik mit großer Bandbreite. Klinikarzt, 5:279-285
Projects
1. Autonomic evaluation of Familial Dysautonomia
2. Vascular dysregulation in Familial Dysautonomia
3. Development of autonomic testing methods
4. Standardization of quantitative sensory testing in children & adults
5. Add-on Study Protocol Nerve growth Factor in Diabetic Neuropathy
6. Cardiac autonomic dysfunction in patients with erectile dysfunction
7. Refined diagnosis of autonomic neuropathies
8. Clinical benefit of Midodrine HCl in patients with neurogenic orthostatic hypotension
9. Influence of epilepsy surgery on central autonomic cardiovascular control
10. Central autonomic regulation before and after epilepsy surgery
11. Development of neuro-physiologic methods evaluating autonomic dysfunction in erectile
dysfunction
12. Influence of nerve growth factor (rhNGF) replacement therapy on diabetic neuropathy
13. Central autonomic dysfunction in Familial Dysautonomia
14. Autonomic dysfunction in Parkinson’s disease
15. Pathophysiology of Orthostatic Intolerance
16. Autonomic Nervous System and metabolic disorders
17. Orthostatic intolerance & central autonomic dysfunction in Familial Dysautonomia
18. Interaction of baroreceptor and chemoreceptor function and influence on cerebrovascular control
in Familial Dysautonomia
19. Assessment of neuro-physiologic and auto-nomic effects of enzyme replacement in Fabry disease
20. Autonomic dysfunction in metabolic neuropathies
21. Assessing neurophysio-logic and autonomic effects of enzyme repla-cement in Fabry disease.
22. Variation in autonomic and small fiber function in normal subjects using repeated measurements
23. Efficacy of recombinant human -galactosidase replacement in patients with Fabry disease
24. Comparison of periphe-ral small fiber & post-ganglionic sudomotor function in hereditary
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Max Hilz
neuropathies
25. Effects of subthalamic nucleus stimulation on cardio- & cerebro-vascular modulation in Parkinson
disiease
26. rhNGF in Diabetic Neuropathy
27. Neurophysiologic and autonomic evaluation Fabry patients.
28. Evaluation of peripheral sudomotor and vaso-motor dysfunction in Familial Dysautonomia
29. Cerebral autoregulation during progressive physical challenge
30. Influence of Sildenafil on cerebral perfusion, auto-regulation & baroreflex sensitivity
31. Pregabalin Open Label, Extension Trial in Patients with Painful Diabetic Neuropathy
32. Interaction between autonomic dysfunction and frontobasal cortical lesions in epilepsy pats.
33. Influence of Sildenafil on cerebral perfusion and autoregulation and baroreflex sensitivity
34. Development of autonomic testing equipment in erectile dysfunction
35. Cardiovascular and erectile autonomic dysfunction
36. Development of autonomic testing equiment
37. Evaluation of sympathetic and parasympathetic modulation of cardiovascular parameters and of
pupillary hippus by means of spectral analysis
38. Pregabalin in Painful Neuropathies Study Protocol 1008-155
39. Relation between neuro-physiologic and autonomic function and recombinant human betagalactosidase (Fabrazyme) infusion interval in Fabry patients
40. Influence of Sildenafil on cerebral perfusion and autoregulation and baroreflex sensitivity
41. Evaluation of cardiovascular and respiratory control during sleep and arousal in Familial
Dysautonomia patients
42. Relation between neurophysiologic function & dosage interval of alpha-galactosidase A infusion in
Fabry patients
43. Benefits of agalsidase beta therapy on baroreflex sensitivity in Fabry patients
44. Diabetes, Cognition, and the Brain
45. [Brain dysfunction in Obesity and T2DM, impaired cerebro-vascular reactivity due to insulin
resistance - a cause of cognitive impairment in T2DM.
46. Central autonomic dysfunction after traumatic brain injury
47. Central autonomic dysfunction after trau-matic brain injury – a possible cause of increased
mortality
48. Erectile Dysfunction and autonomic nervous system
49. improved clinical assessment of Pompe and Fabry patients
50. Sympathetic skin response in Fabry patients
51. Rare disease awareness activities
52. How to enhance expertise & treatment options for Fabry and Pompe patients
53. Correlation between autonomic dysfunction and NIHSS scores as predictor of cardiac risk after
stroke
54. Sexual Dysfunction (SDF) in patients with Multiple Sclerosis (MS)
55. assessment of auto-nomic complications and resulting vital risk in elderly stroke patients by simple
clinical tests
56. retrospective analysis of treatment data and disease progression in Pompe patients
57. Assessing benefits of agalsidase bela therapy on cerebral blood flow velocity and cerebrovascular resistance
58. Sexual dysfunction on post-stroke patients
59. Prospective observation of autonomic function - correlation between autonomic dysfunction &
disease progression & severty in patients with relapsing remittent MS
CLINICAL TRAILS PARTICIPATION
1. A PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP
STUDY OF THE EFFICACY AND SAFETY OF RECOMBINANT HUMAN NERVE GROWTH
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Max Hilz
FACTOR (rhNGF) IN SUBJECTS WITH DIABETIC PERIPHERAL POLYNEUROPATHY
2. A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study of the Safety and Efficacy of
Recombinant Human beta-Galactosidase A (r-h beta-GAL) Replacement in Patients with Fabry
Disease
3. Evaluation of Autonomic and Small Fiber Function in Patients with Fabry Disease Before and After
Enzyme Replacement Therapy
4. Evaluation of Autonomic and Small Fiber Function in Patients with Fabry Disease During Enzyme
Replacement Therapy
5. Evaluation of Variation in Autonomic and Small Fiber Function in Normal Subjects Using Repeat
Measurements
6. Sexual Dysfunction (SDF) in patients with Multiple Sclerosis (MS)
7. Correlation between autonomic dysfunction and NIHSS scores as predictor of cardiac risk after
stroke
8. Retrospective analysis of routinely assessed stapedius reflex response shows improvement of
small muscle function in Pompe patients receiving enzyme replacement therapy
9. Prospective observation assessing relevance of autonomic nervous system testing and correlation
between autonomic dysfunction and disease progression and severity in patients with relapsing
remittent Multiple Sclerosis
Memberships
1994 Founding Member, German Autonomic Society
since 1996 Secretary, Autonomic Nervous System Research Society, University of Erlg.-Nbg.
since 1997 Member, Section of the Autonomic Nervous System, American Academy of Neurology
since 1997 Member, Section “Diabetes and Nervous System“ of the German Diabetes Society
since 1997 Board of Directors, German Society of Neuromuscular Diseases
since 1999 Board, German Research Society on Erectile Dysfunction “Sexuality & Health“
since 1999 Board, “Diabetes and Nervous System“ Section, German Diabetes Society
1999 - 2002 Secretary, “Autonomic Nervous System” Section, German Neurological Society (DGN)
2002 - 2011 President, German Autonomic Society
2004 - 2008 Board of Directors, American Autonomic Society
2004-2008 President, European Federation of Autonomic Societies (EFAS)
2007 - 2010 Chair, Autonomic Section, American Academy of Neurology
since 2007 Member, Guidelines Committee, German Diabetes Society
2008 - 2014 Chair, Autonomic Nervous System Scientist Panel, European Federation of Neurological
Societies
since 2014 Chair, Autonomic Nervous System Subspecialty Scientific Panel European Academy of
Neurology, EAN
1996 Cooperation in development of autonomic testing reimbursement (CPT) codes
(American Medical Association)
since 2002 Guidelines committee, German Neurological Society (DGN):
guidelines on syncope; guidelines on erectile dysfunction
since 2003 Guidelines committee, German Diabetes Society (DDG): guidelines on neurological
diabetic complications
since 2006 Guidelines committee, European Federation of Neurological Societies:
EFNS guidelines on orthostatic hypotension
2008-2010 Development of autonomic nervous system subspecialty board examination
(United Council of Neurological Subspecialties, USA)
2011 Consensus committee, American Academy of Neurology & American Autonomic Society:
consensus
development on the definition of orthostatic hypotension, neurally mediated syncope and
the postural tachycardia syndrome
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Max Hilz
OTHER PROFESSIONAL ROLES
1988-1992 Member, Commitee for Hospital Hygiene
University of Erlangen-Nuremberg
since 06/1990 Member, Drug Advisory Board,
University Erlangen-Nuremberg
1996 Secretary, Autonomic Research Society,
University Erlangen-Nuremberg
1996 Cooperation in development of autonomic testing CPT codes
(American Medical Association)
since 05/2003 appointed as Neurology Board Examiner by
Bavarian State Medical Board
since 1996 appointed as examiner in Clinical Neurophysiology,
(German Clinical Neurophysiology society)
since1999 Editorial Board, “Clinical Autonomic Research”
since 2012 Clinical Associate Editor,
Autonomic Neuroscience, Basic and Clinical
HONORS / AWARDS
10/15/ 73 – 12/31/80 Scholarship of the Bavarian Government for
Highly Talented Students
01/28/93 Poster Award, German Society for Critical Care
Neurology, Wuppertal, Germany
01/30/2009 Honorary Professor, University of Transylvania,
Brasov, Romania
06/11/2012 Honorary Professor, Zhengzhou University,
Zhengzhou, P.R. China
01/30/2015 15th Valsalva lecturer,
Honorary Member of Italian Autonomic Society
Other Relevant Information
I have trained numerous residents and fellows in general neurology, acute and intensive care
neurology, clinical neurophysiology, and central and peripheral autonomic nervous system diseases at
the University of Erlangen-Nuremberg, at New York University and at many international teaching
conferences.
I have organized at least 25 national and international scientific and teaching conferences to broaden
and deepen the knowledge about the many diseases of the autonomic nervous system.
I believe that my clinical, teaching and scientific activities have added to a wider and better
understanding of the relevance of autonomic nervous system disorders in neurology and medicine in
general.
One of my specific research interests deals with the clinical investigation of the central autonomic
nervous system, its hemispheric and topographic representation, and the long-term cardiovascular
effects of isolated or diffuse brain lesions, e.g. in patents with epilepsy, multiple sclerosis, stroke or
traumatic brain injury.
We were able to contribute to a better understanding of the implications of brain lesions on bodily
function, particularly on the modulation of the cardiovascular system.
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