Max Hilz - European Medicines Agency
Transcription
Max Hilz - European Medicines Agency
Curriculum vitae PERSONAL INFORMATION Max Hilz WORK EXPERIENCE February 1981–April 1982 Resident Hospital of the City of Nuremberg, (Germany) Training in anesthesia and intensive care medicine May 1982–September 1982 Resident, Dept. of ENT University of Erlangen-Nuremberg, (Germany) Training in ear-nose and throat diseases and in the diagnosis of vertigo and dizziness October 1982–June 1984 Resident, Dept. of Neurology University of Erlangen-Nuremberg, (Germany) Training in General Neurology July 1984–August 1986 Resident, Dept. of Psychiatry University of Erlangen-Nuremberg, (Germany) Training in Psychiatry September 1986–June 1990 Resident and Board Certified Neurologist University of Erlangen-Nuremberg, (Germany) Clinical Neurophysiology; Intensive Care Neurology; general neurology July 1990–December 1990 Fellowship in Neuroradiology University of Erlangen-Nuremberg, (Germany) Training in Neuroradiology July 1991–September 1992 Oberarzt-Service, i.e. Attending Neurologist University of Erlangen-Nuremberg, (Germany) Clinical Neurophysiology, General Neurology, autonomic nervous system disorders October 1992–June 1994 Visiting Professor, Dept. of Neurology New York University, (United States) Focus on autonomic nervous system diseases, particularly Hereditary Sensory and Autonomic Neuropathies, orthostatic hypotension, diabetes, epilepsy etc July 1994–September 2013 Attending Neurologist with admitting privileges NYU Tisch Hospital, (United States) Focus on autonomic nervous system diseases, particularly Hereditary Sensory and Autonomic Neuropathies, orthostatic hypotension, diabetes, epilepsy etc September 1994–November 1995 15/10/15 Medical Director, Neurodiagnostic Laboratory NYUMC Tisch Hospital, (United States) © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 1 / 22 Curriculum vitae Max Hilz Clinical Neurophysiology & Autonomic Nervous System Disorders October 1995–August 2012 Consultant Neurologist New York Veterans Affairs Medical Center, (United States) Autonomic Nervous System Disorders July 1996–July 2006 Director, Clinical Neurophysiology and Autonomic Nervous System University Erlangen-Nuremberg, (Germany) Clinical Neurophysiology & Autonomic Nervous System Disorders September 1997–August 2013 Director of Autonomic Diseases Laboratory, Dept. of Neurology New York University Medical Center, (United States) Autonomic Nervous System Disorders April 1999–December 2006 Associate Director, Dysautonomia Treatment and Evaluation Center New York University Medical Center, (United States) Autonomic Nervous System Disorders April 1996–Present Professor and Extraordinarius, Dept. of Neurology University of Erlangen-Nuremberg, (Germany) General Neurology, Clinical Neuropyhsiology, autonomic nervous system disorders EDUCATION AND TRAINING September 1964–June 1973 High school and College Graf-Münster-Gymnasium Bayreuth, (Germany) October 1973–October 1974 Medical School University of Cologne, (Germany) November 1974–December 1980 Medical School Friedrich-Alexander University of Erlangen-Nuremberg, (Germany) February 1981–April 1984 Resident, Dept. of Anesthesiology & Intensive Care Medicine Hospital of the City of Nuremberg; Nuremberg, (Germany) May 1982–September 1982 Resident, Department of ENT University of Erlangen-Nuremberg, (Germany) October 1982–June 1984 Resident, Dept. of Neurology University of Erlangen-Nuremberg, (Germany) July 1984–August 1986 Resident, Dept. of Psychiatry University of Erlangen-Nuremberg, (Germany) 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 2 / 22 Curriculum vitae September 1986–March 1988 Max Hilz Resident, Dept. of Neurology University of Erlangen-Nuremberg, (Germany) March 1988–June 1990 Fellow and Board Certified Neurologist Dept. of Neurology, University of Erlangen-Nuremberg, (Germany) July 1990–December 1990 Fellowship in Neuroradiology Department of Neuroradiology, University of Erlangen-Nuremberg, (Germany) ADDITIONAL INFORMATION Expertise I have more than 25 years of experience with autonomic nervous system disorders and conducted many international studies in an autonomic laboratory at New York University, New York, NY, USA, and at the UNiversity of Erlangen-Nuremberg, Erlangen, Germany. To better understand autonomic feedback loops and organ interactions, we use sophisticated testingprocedures, such as combined chemoreflex and sinusoidal baroreflex stimulation. We studied a wide spectrum of autonomic disorders associated with common diseases, such as diabetes, obesity, stroke, epilepsy, traumatic brain injury, Parkinson disease, Multiple Sclerosis, Guillain-Barré-Syndrome, amyotrophic lateral sclerosis, normal-pressure glaucoma, Syncope or POTS, as well as rare hereditary or neurodegenerative disorders, including Hereditary Sensory and Autonomic Neuropathies Fabry disease. I am particularly interested in the effects of central autonomic network lesions on the cardiovascular system, e.g. in patients with epilepsy, multiple sclerosis, stroke or traumatic brain injury, in orthostatic hypotension and postural tachycardia syndrome (POTS). Publications Peer Reviewed Original Contributions 1. Schellmann B, Hilz MJ, Opitz O (1980) Cadmium- und Kupferausscheidung nach Aufnahme von Champignon-Mahlzeiten. Z Lebenssm Unters Forsch, 171:189-92 [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 2. Claus D, Hilz MJ, Hummer I, Neundörfer B (1987) Methods of measurement of thermal thresholds. Acta Neurol Scand, 76:288-96 (IF 1.71) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 3. Hilz MJ, Claus D, Neundörfer B (1988) Early diagnosis of diabetic small fiber neuropathy by disturbed cold perception. J Diabetes Complicat, 2:38-43 (IF 1.86) 4. Hilz MJ, Huk W, Druschky KF, Erbguth (1989) Fat deposition surrounding intracerebral hemorrhage in a patient suffering from Zieve-syndrome. Neuroradiology, 31:102-3 (IF 1.51) 5. Bauer J, Stefan H, Huk WJ, Feistel H, Hilz MJ, Brinkmann HG, Druschky KF, Neundörfer B (1989) CT, MRI and SPECT neuroimaging in Status epilepticus with simple partial and complex partial seizures: case report. J Neurol, 236:296-99 (IF 3.14) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 6. Druschky KF, Pfurtscheller G, Litscher G, Hilz MJ, Schwarz G, Jahns I, Neundörfer B (1989) Visuell evozierte Potentiale bei primär infra- und supratentoriellen Läsionen. Visual evoked potentials in patients with primary infratentorial and supratentorial lesions. Intensivbehandlung, 14:168-73 [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 7. Mösler TA, Koniszewski G, Barocka A, Höll R, Hilz MJ, Frontzek T, Rossa U (1989) Psychogene Störungen des visuellen Systems. Eine Studie an Erwachsenen und Kindern. Augenärztliche Fortbildung, 12:54-61 [Data interpretation, drafting or revising critically important intellectual content] 8. Hilz MJ, Bauer J, Druschky KF, Huk WJ, Neundörfer B (1990) Zieve's syndrome and intracranial hemorrhage: coincidence or related disorders. J Neurol, 237:120-21 (IF 3.14) 9. Hilz MJ, Druschky KF, Bauer J, Neundörfer B, Schuierer G (1990) Morbus Wilson - kritische Verschlechterung unter hochdosierter parenteraler Penicillamin-Therapie. Wilson's disease deterioration with high-dosage parenteral penicillamine treatment. Dtsch Med Wschr, 115:93-97 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 3 / 22 Curriculum vitae Max Hilz 10. Hilz MJ, Claus D, Bauer J, Neundörfer B (1990) Transkutaner Herzschrittmacher in der Prophylaxe und Notfalltherapie bei Neurologischen Intensivpatienten. Nervenarzt; 61:744-48 (IF 0.89) 11. Hilz MJ, Huk W, Schellmann B, Sörgel F, Druschky KF (1990) Fatal complications after myelography with meglumine diatrizoate. Neuroradiology, 32:70-73 (IF 1.51) 12. Weis M, Hilz MJ, Claus D, Neundörfer B, Druschky KF, Litscher G, Pfurtscheller G (1990) Longtime monitoring - Options to use on patients in neurologic intensive care units. J Clin Monitoring, 6:168-69 [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 13. Hilz MJ, Neundörfer B, Engelhardt A, Claus D, Grahmann F (1990) Idiopathische Polyradikuloneurits Landry-Guillain Barré nach Kohlenmonoxyd-Vergiftung. Landry-Guillain-Barré Syndrome after Carbon Monoxide Intoxication. Akt Neurol, 17:113-16 (IF 0.33) 14. Claus D, Hilz MJ, Neundörfer B (1990) Thermal discrimination thresholds: a comparison of different methods. Acta Neurol Scand, 81:533-40 (IF 1.71) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 15. Erbguth F, Druschky KF, Gmeiner HJ, Hilz MJ, Neundörfer B (1990) Bilaterale Thalamusläsionen bei Hirnvenenthrombosen. Nervenarzt, 61:123-26 (IF 0.89) [Data interpretation, drafting or revising critically important intellectual content] 16. Hilz MJ, Litscher G, Weis M, Claus D, Druschky KF, Pfurtscheller G, Neundörfer B (1991) Continuous multivariable monitoring in neurological intensive care patients - preliminary reports on four cases. Intensive Care Med, 17:87-93 (IF 3.03) 17. Rechlin T, Hilz MJ, Claus D (1991) Erfolgreiche Behandlung des malignen neuroleptischen Syndroms mit Dantrolen-Natrium i.v. auf der neurologischen Intensivstation. Anästhesiol Intensivmed. Notfallmed. Schmerzther, 26:156-60 [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 18. Bauer J, Schüler P, Feistel H, Hilz MJ, Stefan H (1991) Blindness as an ictal phenomenon. Investigations with EEG and SPECT in two patients suffering from epilepsy. J Neurol, 238:44-46 (IF 3.14) [Data interpretation, drafting or revising critically important intellectual content] 19. Hilz MJ, Bauer J, Claus D, Stefan H, Neundörfer B (1992) Isoflurane anaesthesia in the treatment of convulsive status epilepticus. J Neurol, 239:135-37 (IF 3.14) 20. Hilz MJ, Claus D, Balk M, Neundörfer (1992) Influence of caffeine, sweating and local hyperemisation on "Marstock" thermotesting. Acta Neurol Scand, 86:19-23 (IF 1.71) 21. Hilz MJ, Claus D, Druschky KF, Rechlin T (1992) Air fluidization therapy of pressure sores due to Guillain-Barré and Cushing syndrome. Intensive Care Med, 18:62-63 (IF 3.03) 22. Hilz MJ, Litscher G, Pfurtscheller G, Schwarz G, Druschky KF, Neundörfer B (1993) Visuell evozierte Potentiale: Zum Einfluß primärer Hirnstammläsionen auf die Skalp-Topographie. Z EEG EMG, 24:258-62 23. Hilz MJ, Claus D, Neundörfer B, Zimmermann P, Beric A (1994) Is heat hypoalgesia a useful parameter in quantitative thermal testing of alcoholic polyneuropathy? Muscle Nerve, 17:1456-60 (IF 2.43) 24. Hilz MJ, Zimmermann P, Claus D, Neundörfer (1995) Thermal threshold determination in alcoholic polyneuropathy - an improvement of diagnosis. Acta Neurol Scand, 91:389-93 (IF 1.71) 25. Hilz MJ, Glorius S, Beric A (1995) Thermal perception thresholds: influence of determination paradigm and reference temperature. J Neurol Sci, 129:135-40 (IF 2.37) 26. Hilz MJ, Erbguth F, Stefan H, Neundörfer B (1995) Isoflurane for seven days in refractory status epilepticus. Eur J Neurol, 2:95-99 (IF 2.22) 27. Hilz MJ, Claus D, Rösl G, Hofmann E, Braun J, Neundörfer B (1995) Besserung des TemperaturundVibrationsempfindens bei chronischer Urämie nach Einzeldialyse. Fortschr Neurol Psychiat, 63:264-69 (IF 0.75) 28. Hilz MJ, Zimmermann P, Rösl G, Scheidler W, Braun J, Stemper B, Neundörfer B (1995) Vibrameter testing facilitates the diagnosis of uremic and alcoholic polyneuropathy. Acta Neurol Scand, 92:486-90 (IF 1.71) 29. Hilz MJ, Glorius SE, Schweibold G, Neuner I, Stemper B, Axelrod FB (1996) Quantitative thermal perception testing in preschool children. Muscle Nerve, 19:381-83 (IF 2.43) 30. Neundörfer B, Hilz MJ, Wimbauer M (1996) Zum Verlauf und zur Prognose von Patienten einer neurologischen Intensivstation unter besonderer Berücksichtigung des Alters. Fortschr Neurol Psychiat; 64:285-91 (IF 0.75) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 31. Grahmann F, Schober S, Hilz MJ (1996) Neundörfer B. Late life polyneuropathy. AGE, 19:13-16 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 4 / 22 Curriculum vitae Max Hilz (IF 1.64) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 32. Warner LE, Hilz MJ, Appel SH, Killian JM, Kolodny EH, Karpati G, Carpenter S, Watters GV, Wheeler C, Witt D, Bodell A, Nelis E, Van Broeckhoven C, Lupski JR (1996) Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination. Neuron, 17:451-60 (IF 14.43) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 33. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (1997) Benign exertional headache/benign sexual headache: a disorder of myogenic cerebrovascular autoregulation? Headache, 37:597-98 (IF 2.30) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 34. Heckmann JG, Erbguth F, Hilz MJ, Huk W, Neundörfer B (1997) Effect of dopamine on middle cerebral artery blood flow: a single case study. Neurol Psychiat Brain Res, 5:107-10 (IF 0.16) [Data interpretation, drafting or revising critically important intellectual content] 35. Weiser M, Hilz MJ, Bronfin L, Axelrod FB (1998) Assessing microcirculation in familial dysautonomia by laser Doppler flowmetry. Clin Auton Res, 8:13-23 (IF 0.83) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 36. Heckmann JG, Mück-Weymann M, Katalinic A, Hilz MJ, Claus D, Neundörfer B (1998) TCDErgometer-Test bei Patienten mit chronischem Kopfschmerz vom Spannungstyp (CKST). Nervenarzt, 69:131-36 (IF 0.89) [Data interpretation, drafting or revising critically important intellectual content] 37. Heckmann JG, Hilz MJ, Katalinic A, Marthol H, Mück-Weymann M, Neundörfer B (1998) Myogenic cerebrovascular autoregulation in migraine measured by stress transcranial Doppler sonography. Cephalalgia, 18:133-37 (IF 3.13) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 38. Hilz MJ, Kolodny EH, Neuner I, Stemper B, Axelrod FB (1998) Highly abnormal thermotest in Familial Dysautonomia suggests increased cardiac risk.J Neurol Neurosurg Psychiatry, 65:338-43 (IF 3.11) 39. Hilz MJ, Axelrod FB, Hermann K, Haertl U, Duetsch M, Neundörfer B (1998) Normative values of vibratory per-ception in 530 preschool children, juveniles and adults aged 3 to 79 years. J Neurol Sci, 159:219-25 (IF 2.36) 40. Hilz MJ, Stemper B, Schweibold G, Neuner I, Grahmann F, Kolodny EH (1998) Quantitative thermal perception testing in 225 children and juveniles. J Clin Neurophysiol,15:529-34 (IF 1.53) 41. Hilz MJ, Stemper B, Axelrod FB (1999) Sympathetic Skin Response differentiates Hereditary Sensory Autonomic Neuropathies III and IV. Neurology, 52:1652-57 (IF 5.97) 42. Heckmann JG, Hilz MJ, Hagler H, Mück-Weymann M, Neundörfer B (1999) Transcranial Doppler sonography during acute 80° head-down tilt (HDT) for the assessment of cerebral autoregulation in humans. Neurol Res, 21:457-62 (IF 1.21) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 43. Druschky A, Spitzer A, Platsch G, Claus D, Feistel H, Druschky K, Hilz MJ, Neundörfer B (1999) Cardiac sympathetic denervation in early stages of amyotrophic lateral sclerosis demonstrated by 123-I-MIBG-SPECT. Acta Neurol Scand, 99:308-14 (IF 1.71) [Data interpretation, drafting or revising critically important intellectual content] 44. Druschky K, Hilz MJ, Kölsch C, Platsch G, Neundörfer B (1999) Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT. J Auton Nerv Syst, 76:184-87 (IF 1.31) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 45. Hilz MJ, Stemper B, Sauer P, Haertl U, Singer W, Axelrod FB (1999) Cold face test demonstrates parasympathetic cardiac dysfunction in familial dysautonomia. Am J Physiol, 276:R1833-39 (IF 3.53) 46. Hecht M, Kober H, Claus D, Hilz M, Vieth J, Neundörfer B (1999) The electrical and magnetical cerebral responses evoked by electrical stimulation of the esophagus and the location of their cerebral sources. J Clin Neurophysiol, 110:1435-44 (IF 1.53) [Data interpretation, drafting or revising critically important intellectual content] 47. Hilz MJ, Stemper B, Axelrod FB, Kolodny EH, Neundörfer B (1999) Quantitative thermal perception testing in adults. J Clin Neurophysiol, 16:462-71 (IF 1.53) 48. Heckmann JG, Niedermeier W, Brandt-Pohlmann M, Hilz MJ, Hecht M, Neundörfer B (1999) Detektion eines offenen Foramen ovale: Transösophageale Echokardiographie und transcranielle Doppler-Sonographie mit Echovist sind „ergänzende, nicht-konkurrierende Methoden“. Med Klin, 36770 (IF 0.47) [Data interpretation, drafting or revising critically important intellectual content] 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 5 / 22 Curriculum vitae Max Hilz 49. Heckmann JG, Leis S, Mück-Weymann M, Hilz MJ, Neundörfer B (1999) Vestibular evoked blood flow response in the basilar artery. Acta Neurol Scand, 100:12-17 (IF 1.71) [Data interpretation, drafting or revising critically important intellectual content] 50. Hilz MJ, Axelrod FB, Schweibold G, Kolodny EH (1999) Sympathetic skin response following thermal, electrical, acoustic and inspiratory gasp stimulation in Familial Dysautonomia patients and healthy persons. Clin Auton Res, 9:165-77 (IF 0.83) 51. Saleh Y, Kirchner A, Pauli E, Hilz MJ, Neundörfer B, Stefan H (2000) Temporallappenepilepsien – Einfluß der Fokusseite auf die autonome Regulation der Herzfrequenz? Nervenarzt, 71:477-80 (IF 0.89) [Data interpretation, drafting or revising critically important intellectual content] 52. Kilo S, Berghoff M, Hilz M, Freeman R (2000) Neural and Endothelial Control of the Microcirculation in Diabetic Peripheral Neuropathy. Neurology, 54:1246-52 (IF 5.97) [Data interpretation, drafting or revising critically important intellectual content] 53. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (2000) Transcranial Doppler sonography – ergometer test for the non-invasive assessment of cerebrovascular autoregulation in humans. J Neurol Sci, 177:41-47 (IF 2.36) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 54. Hilz MJ, Stemper B, Kolodny EH (2000) Lower limb cold exposure induces pain and prolonged small fiber dysfunction in Fabry patients. PAIN, 84:361-65 (IF 4.06) 55. Druschky A, Hilz MJ, Platsch G, Radespiel-Tröger M, Druschky K, Kuwert T, Neundörfer B (2000) Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means of I-123-MIGB-SPECT. J Neurol Sci, 175:3-12 (IF 2.36) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 56. Hilz MJ, M Hecht M, Berghoff M, Singer W, Neundörfer B (2000) Abnormal vasoreaction to arousal stimuli - an early sign of diabetic sympathetic neuropathy demonstrated by Laser Doppler flowmetry. J Clin Neurophysiol, 17:419-25 (IF 1.53) 57. Axelrod F, Zupanc M, Hilz MJ, Kramer EL (2000) Ictal SPECT during autonomic crisis in Familial Dysautonomia. Neurology, 55:122-25 (IF 5.97) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 58. Hilz MJ, Axelrod FB (2000) Quantitative sensory testing of thermal and vibratory perception in familial dysautonomia. Clin Auton Res, 10:177-83 (IF 0.83) 59. Reinhardt F, Wetzel T, Vetten S, Radespiel-Tröger M, Hilz MJ, Heuss D, Neundörfer B (2000). Peripheral neuropathy in chronic venous insuffiency. Muscle Nerve; 6: 883-87 (IF 2.43) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 60. Heckmann JG, Hilz MJ, Hummel T, Popp M, Marthol H, Neundörfer B, Heckmann SM (2000) Oral mucosal blood flow following dry ice stimulation in humans. Clin Auton Res, 10:317-21 (IF 0.83) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 61. Hilz MJ, Dütsch M, Perrine K, Nelson PK, Rauhut U, Devinsky O (2001) Hemispheric influence on autonomic modulation and baroreflex sensitivity. Ann Neurol, 49:575-84 (IF 8.09) 62. Druschky A, Herkert M, Radespiel-Tröger M, Druschky K, Hund E, Becker CM, Hilz MJ, Erbguth F, Neundörfer B (2001) Critical illness polyneuropathy: Clinical findings and cell culture assay of neurotoxicity assessed by a prospective study. Intensive Care Med, 27:686-93 (IF 3.03) [Data interpretation, drafting or revising critically important intellectual content] 63. Hecht MJ, Neundörfer B, Kiesewetter F, Hilz MJ (2001) Neuropathy is a major contribution factor to diabetic erectile dysfunction. Neurol Res, 23:651-54 (IF 1.21) [Conception and design of Study, drafting or revising critically important intellectual content] 64. Hecht MJ, Fellner F, Fellner C, Hilz MJ, Heuss D, Neundörfer B (2001) MRI-FLAIR images of the head show corticospinal tract alterations in the ALS patients more frequently than T2-, T1- and proton density weighted images. J Neurol Sci, 186:37-44 (IF 2.36) [drafting or revising critically important intellectual content] 65. Heckmann SM, Heckmann JG, Hilz MJ, Popp M, Marthol H, Neundörfer B (2001) Hummel T. Oral mucosal blood flow in patients with burning mouth syndrome. PAIN, 90:281-86 (IF 4.06) [Data interpretation, drafting or revising critically important intellectual content] 66. Singer W, Tonette L, Opfer-Gehrking, McPhee BR, Hilz MJ, Low PA (2001) Influence of posture on the Valsalva manoeuvre. Clin Sci; 100: 433-40 (IF 2.16) [drafting or revising critically important intellectual content] 67. Druschky A, Hilz MJ, Hopp P, Platsch G, Radespiel-Tröger M, Druschky K, Kuwert T, Stefan H, 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 6 / 22 Curriculum vitae Max Hilz Neundörfer B (2001) Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated by [123I]metaiodobenzylguanidine-SPECT. Brain, 124:2372-82 (IF 8.2) [drafting or revising critically important intellectual content] 68. Hilz MJ, Devinsky O, Doyle W, Mauerer A, Dütsch M (2002) Decrease of sympathetic cardiovascular modulation after temporal lobe epilepsy surgery. Brain, 125:985-95 (IF 8.2) 69. Dütsch M, Hilz MJ, Rauhut U, Solomon J, Neundörfer B, Axelrod FB (2002) Sympathetic and parasympathetic pupillary dysfunction in familial dysautonomia. J Neurol Sci, 195:77-83 (IF 2.36) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 70. Brown C, Dütsch M, Michelson G, Neundörfer B, Hilz MJ (2002) Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma. Clin Sci,102:62330 (IF 2.16) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 71. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R (2002) Vascular and neural mechanisms of Ach-mediated vasodilatation in the forearm cutaneous mircrocirculation. J Appl Physiol, 92:780-88 (IF 2.82) [drafting or revising critically important intellectual content] 72. Stemper B, Hilz MJ, Rauhut U, Neundörfer B (2002) Evaluation of cold face test bradycardia by means of spectral analysis. Clin Auton Res, 12:78-83 (IF 0.83) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 73. Hilz MJ, Axelrod FB, Braeske K, Stemper B (2002) Cold pressor test demonstrates residual sympathetic cardiovascular activation in familial dysautonomia. J Neurol Sci, 196:81-89 (IF 2.36) 74. Hilz MJ, Axelrod FB, Haertl U, Brown CM, Stemper B (2002) Transcranial Doppler sonography during head up tilt suggests preserved central sympathetic activation in familial dysautonomia. J Neurol Neurosurg Pschiat, 72:657-60 (IF 3.11) 75. Hecht MJ, Fellner F, Fellner C, Hilz MJ, Neundörfer B, Heuss D (2002) Hyperintense and hypointense MRI signals of the precentral gyrus and the pyramidal tract in ALS - a follow up examination including FLAIR images. J Neurol Sci, 199:59-65 (IF 2.36) [drafting or revising critically important intellectual content] 76. Singer W, Win-Kuang S, Opfer-Gehrking L, McPhee BR, Hilz MJ, Low PA (2002) Evidence of an instrinsic sinus node abnormality in patients with postural tachycardia syndrome. Mayo Clin Proc, 77:246-52 (IF 3.74) [drafting or revising critically important intellectual content] 77. Lang E, Hilz MJ, Erxleben H, Ernst M, Neundörfer B, Liebig K (2002) Reversible prolongation of motor conduction time after transcranial magnetic brain stimulation following neurogenic claudication in spinal stenosis. Spine, 7:2284-90 (IF 2.29) [drafting or revising critically important intellectual content] 78. Hilz MJ, Axelrod FB, Steingrüber M, Stemper B (2002) Valsalva maneuver suggests increased rigidity of cerebral resistance vessels in Familial Dysautonomia. Clin Auton Res, 12:385-92 (IF 0.83) 79. Kirchner A, Pauli E, Hilz MJ, Neundörfer B, Stefan H (2002) Sex differences and lateral asymmetry in heart rate modulation in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry, 72:73-75 (IF 3.11) [drafting or revising critically important intellectual content] 80. Sommer JB, Schoerner C, Heckmann JG, Neundörfer B, Hilz MJ (2002) Mononeuritis multiplex due to Coixella Burnetii infection (Q fever). Acta Neurol Scand, 106:371-73 (IF 1.71) [revising critically important intellectual content] 81. Bickel A, Krämer H, Hilz MJ, Birklein F, Neundörfer B, Schmelz M (2002) Assessment of the neurogenic flare reaction in small fiber neuropathies. Neurology, 59:617-19 (IF 5.97) [ revising critically important intellectual content] 82. Bickel A, Axelrod FB, Schmelz M, Marthol H, Hilz MJ (2002) Dermal microdialysis provides evidence for hypersensitivity to norepinephrine in familial dysautonomia patients. J Neurol Neurosurg Psychiatry, 73:299-302 (IF 3.11) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 83. Dütsch M, Marthol H, Stemper B, Brys M, Haendl T, Hilz MJ (2002) Small fiber neuropathy predominates in Fabry neuropathy. J Clin Neurophysiol, 19:575-86 (IF 1.53) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 84. Hilz MJ, Hecht MJ, Mittelhamm F, Neundörfer B, Brown CM (2002) Baroreflex stimulation shows impaired cardiovagal and preserved vasomotor function in early stage amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord, 3:137-44 (IF 1.21) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 85. Hecht MJ, Hillemacher T, Gräsel E. Tigges S. Winterholler M, Heuss D, Hilz MJ, Neundörfer B 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 7 / 22 Curriculum vitae Max Hilz (2002) Subjective experience and coping in ALS. Amyotroph Lateral Scler Other Motor Neuron Disord, 3:225-31 (IF 1.21) [drafting or revising critically important intellectual content] 86. Kolominsky-Rabas PL, Hilz MJ, Neundörfer B, Heuschmann PU (2003) Impact of urinary incontinence after stroke: results from a prospective population-based stroke register. Neurourol Urodynam, 22:322-27 (IF 3.65) [drafting or revising critically important intellectual content] 87. Werner D, Marthol H, Brown CM, Daniel WG, Hilz MJ (2003) Changes of cerebral blood flow velocities during enhanced external counterpulsation (EECP). Acta Neurol Scand, 107:405-11 (IF 1.71) 88. Brown CM, Stemper B, Welsch G, Brys M, Axelrod FB, Hilz MJ (2003) Orthostatic challenge reveals impaired vascular resistance control, but normal venous pooling and capillary filtration in familial dysautonomia. Clin Sci, 104:163-69 (IF 2.16) 89. Bernardi L, Hilz MJ, Stemper B, Passino C, Welsch G, Axelrod FB (2003) Respiratory and cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia. Am J Resp Crit Care, 167:141-49 (IF 8.12) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 90. Singer W, Shen WK, Opfer-Gehrking TL, McPhee BR, Hilz MJ (2003) Heart rate-dependent electrocardio-gramm abnormalities in patients with postural tachycardia syndrom. Auton Neurosci, 103:106-13 (IF 1.31) 91. Brown, CM, Hecht MJ, Weih A, Neundörfer B, Hilz MJ (2003) Effects of age on the cardiac and vascular limbs of the arterial baroreflex. Eur J Clin Invest, 33:10-16 (IF 2.53) 92. Brown CM, Dütsch M, Hecht MJ, Neundörfer B, Hilz MJ (2003) Assessment of cerebrovascular and cardiovascular responses to lower body negative pressure as a test of cerebral autoregulation. J Neurol Sci, 208:71-78 (IF 2.36) 93. Stemper B, Hilz MJ (2003) Postischemic cutaneous hyperperfusion in the presence of forearm hypoperfusion suggests sympathetic vasomotor dysfunction in Fabry disease. J. Neurology, 250:97076 (IF 5.97) 94. Hecht MJ, Brown CM, Mittelhamm F, Werner D, Neundörfer B, Hilz MJ (2003) Increased hypoxic blood pressure response in patients with amyotrophic lateral sclerosis. J Neurol Sci, 213:47-53 (IF 2.36) 95. Brys M, Brown C, Marthol H, Franta R, Hilz MJ (2003) Dynamic cerebral autoregulation remains stable during physical challenge in healthy persons. Am J Physiol C, 285:H1048-H54 (IF 3.53) 96. Stemper B, Axelrod F, Marthol H, Brown C, Brys M, Welsch G, Hilz MJ (2003) Terminal vessel hyperperfusion despite organ hypoperfusion in familial dysautonomia. Clin Sci, 105:295-301 (IF 2.16) 97. Brown CM, Sanya EO, Hilz MJ (2003) Effect of cold face stimulation on cerebral bood flow in humans. Brain Res Bull, 61:81-86 (IF 2.42) 98. Brown CM, Hecht MJ, Neundörfer B, Hilz MJ (2003) Effects of lower body negative pressure on cardiac and vascular responses to carotid baroreflex stimulation. Physiol Res, 52:637-45 (IF 1.14) 99. Sanya EO, Brown CM, Dütsch M, Zikeli U, Neundorfer B, Hilz MJ (2003) Impaired cardiovagal and vasomotor responses to baroreceptor stimulation in type II diabetes mellitus, Eur J Clin Invest, 33:582-88 (IF 2.53) 100. Marthol H, Tutaj M, Brys M, Brown C, Hecht M, Berlin D, Axelrod FB, Hilz MJ (2003) Clonidine improves postprandial baroreflex control in familial dysautonomia. Eur J Clin Invest, 33:912-18 (IF 2.53) 101. Hilz MJ, Platsch G, Druschky K, Pauli E, Kuwert T, Stefan H, Neundörfer B, Druschky A (2003) Outcome of epilepsy surgery correlates with sympathetic modulation and neuroimaging of the heart. J Neurol Sci, 216:153-62 (IF 2.36) 102. Hecht MJ, Graesel E, Tigges S, Hillemacher T, Winterholler M, Hilz MJ, Heuss D, Neundörfer B (2003) Burden of care in amyotrophic lateral sclerosis. Palliat Med, 17:327-33 (IF 1.12) [drafting or revising critically important intellectual content] 103. Heckmann JG, Brown CM, Cheregi M, Hilz MJ, Neundörfer B (2003) Delayed cerebrovascular autoregulatory response to ergometer exercise in normotensive elderly humans. Cerebrovasc Dis, 16:423-29 (IF 2.15) [Data analysis and interpretation, drafting or revising critically important intellectual content] 104. Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA (2003) Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry, 74:1294-98 (IF 3.11) [drafting or revising critically important intellectual content] 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 8 / 22 Curriculum vitae Max Hilz 105. Brown CM, Dütsch M, Ohring S, Neundorfer B, Hilz MJ (2004) Cerebral autoregulation is compromised during simulated fluctuations in gravitational stress. Eur J Appl Physiol, 91:279-86 (IF 2.82) 106. Bickel A, Axelrod FB, Marthol H, Schmelz M, Hilz MJ (2004) Sudomotor function in Familial Dysautonomia, J Neurol Neurosurg Psychiatry, 75:275-79 (IF 3.11) 107. Hilz MJ, Brys M, Marthol H, Stemper B, Dütsch M (2004) Enzyme replacement therapy improves function of C-, A delta- and A beta-nerve fibers in Fabry neuropathy. Neurology, 62:1066-72 (IF 5.97) 108. Tutaj M, Brown CM, Brys M, Marthol H, Hecht MJ, Dütsch M, Michelson G, Hilz MJ (2004) Dynamic cerebral autoregulation is impaired in glaucoma. J Neurol Sci, 220:49-54 (IF 2.36) 109. Dütsch M, Marthol H, Michelson G, Neundörfer B, Hilz MJ (2004) Pupillography refines the diagnosis of diabetic autonomic neuropathy. J Neurol Sci, 222:75-81 (IF 2.36) 110. Hilz MJ, Kolodny EH, Brys M, Stemper B, Haendl T, Marthol H (2004) Reduced cerebral blood flow and impaired cerebral autoregulation in Fabry patients. J Neurol, 251:564-70 (IF 3.14) 111. Stemper B, Bernardi L, Axelrod F, Welsch G, Passino C, Hilz MJ (2004) Sympathetic and parasympathetic baroreflex dysfunction in Familial Dysautonomia. Neurology, 63:1427-31 (IF 5.97) 112. Dütsch M, Devinsky O, Doyle W, Marthol H, Hilz MJ (2004) Cerebral autoregulation improves in epilepsy patients after temporal lobe surgery. J Neurol, 251:1190-7 (IF 3.14) 113. Hilz MJ, Werner D, Marthol H, Flachskampf FA, Daniel WG (2004) Enhanced external counterpulsation improves skin oxygenation and perfusion. Eur J Clin Invest, 34:385-91 (IF 2.53) 114. Hilz MJ, Axelrod F, Bickel A, Stemper B, Brys M, Wendelschafer-Crabb, Kennedy W (2004) Assessing function and pathology in familial dysautonomia: Assessment of temperature perception, sweating and cutaneous innervation. Brain, 127:2090-8 (IF 8.2) 115. Marthol H, Werner D, Brown C, Hecht M, Daniel WG, Hilz MJ (2005) Enhanced external counterpulsation does not compromise cerebral autoregulation. Act Neurol Scand, 111:34-41 (IF 1.71) 116. Sanya EO, Brown CM, Wilmowsky C, Neundörfer B, Hilz MJ (2005) Impairment of parasympathetic baroreflex responses in migraine patients. Acta Neurol Scand, 111:102-7 (IF 1.71) 117. Sanya EO, Tutaj M, Brown CM, Goel N, Neundörfer B, Hilz MJ (2005) Abnormal heart rate and blood pressure responses to baroreflex stimulation in multiple sclerosis patients. Clin Auton Res, 15:213-18 (IF 0.83) 118. Sanya EO, Tutaj M, Brown CM, Goel N, Neundörfer B, Hilz MJ. (2005) Letter to the Editors. Response to Flachenecker et al. Abnormal baroreflex responses in Multiple sclerosis. Clin Auton Res, 15:420 (IF 0.83) 119. Tutaj M, Marthol H, Berlin D, Brown CM, Axelrod FB, Hilz MJ (2006) Effect of physical countermanoevers on orthostatic hypotension in Familial Dysautonomia, J Neurol, 253:65-72 (IF 3.14) 120. Berghoff M, Kilo S, Hilz M, Freeman R (2006) Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve, 33:494-499 (IF 2.43) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 121. Marthol H,Reich S, Jacke J, Lechner K.H., Wichmann M, Stemper B, Hilz MJ (2006) Enhanced sympathetic cardiac modulation in bruxism patients. Clin Auton Res, 16:276-280 (IF 0.83) 122. Dütsch M, Hilz MJ, Devinsky O (2006) Impaired baroreflex function in temporal lobe epilepsy. J Neurol, 253:1300-8 (IF 3.14) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 123. Stemper B, Beric A, Welsch G, Haendl T, Sterio D, Hilz MJ (2006) Deep brain stimulation improves orthostatic regulation of Parkinson patients. Neurology, 67:1781-5.(IF 5.97) 124. Marthol H, Brown CM, Zikeli U, Ziegler D, Dimitrov N, Baltadhzieva R, Hilz MJ (2006) Altered cerebral regulation in type 2 diabetic patients with cardiac autonomic neuropathy. Diabetologia, 49:2481-7 (IF 5.24) 125. Hilz MJ, Devinsky O, Szczepanska H, Borod J, Marthol H, Tutaj M (2006) Right ventromedial prefrontal lesions result in paradoxical activation with emotional stimuli. Brain, 129:3343-55 (IF 8.2) 126. Marthol H, Zikeli U, Brown CM, Tutaj M, Hilz MJ (2007) Cardiovascular and cerbrovascular responses to lower body negative pressure in type 2 diabetic patients. J Neurol Sci, 252:99-105 (IF 2.36) 127. Peters A, Schwarze B, Tomandl B, Probst-Cousin S, Lang C, Hilz M (2007) Bilateral striatal hyperintensities on diffusion weighted MRI in acute methanol poisoning. Eur J Neurol, 14:e1-2 (IF 2.22) 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 9 / 22 Curriculum vitae Max Hilz 128. Huttner HB, Richter G, Hildebrandt M, Blümcke I, Fritscher T, Brück W, Gärtner J, Seifert F, Staykov D, Hilz MJ, Schwab S, Bardutzky J (2007) Acute onset of fatal vegetative symptoms: unusual presentation of adult Alexander disease. Eur J Neurol, 14:1251-5 (IF 2.22) [drafting or revising critically important intellectual content] 129. Dütsch M, Burger M, Dörfler C, Schwab S, Hilz MJ (2007) Cardiovascular autonomic function in poststroke patients. Neurology, 69:2249-55 (IF 5.97) 130. Hilz MJ. Peripheral nervous system involvement in Fabry disease: role in morbidity and mortality (2007) Clin Ther. Suppl A:S11-2. No abstract available. Erratum in: Clin Ther, 29:2268. 131. Stemper B, Devinsky O, Haendl T, Welsch G, Hilz MJ (2008) Effects of vagus nerve stimulation on cardiovascular regulation in patients with epilepsy. Act Neurol Scand, 117:231-6 (IF 1.71) 132. Kanter IC, Huttner HB, Staykov D, Biermann T, Struffert T, Kerling F, Hilz MJ, Schellinger PD, Schwab S, Bardutzky J (2008) Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus.Epilepsia, 49:914-20 (IF 3.52) [drafting or revising critically important intellectual content] 133. Seifert F, Struffert T, Hildebrandt M, Blümcke I, Brück W, Staykov D, Huttner HB, Hilz MJ, Schwab S, Bardutzky J (2008) In vivo detection of hepatitis C virus (HCV) RNA in the brain in a case of encephalitis: evidence for HCV neuroinvasion. Eur J Neurol, 15:214-8 (IF 2.22) [drafting or revising critically important intellectual content] 134. Brown CM, Marthol H, Zikeli U, Ziegler D, Hilz MJ (2008) A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients. Diabetologia, 51:756-61 (IF 5.24) 135. Solaimanzadeh I, Schlegel TT, Feiveson AH, Greco EC, DePalma JL, Starc V, Marthol H, Tutaj M, Buechner S, Axelrod FB, Hilz MJ (2008) Advanced electrocardiographic predictors of mortality in Familial Dysautomia. Autonomic Neuroscience: Basic and Clinical, 144:76-82 (IF 1.75) 136. Kiphuth IC, Staykov D, Kohrmann M, Struffert T, Richter G, Bardutzky J, Kollmar R, Maurer M, Schellinger PD, Hilz MJ, Doerfler A, Schwab S, Huttner HB (2009) Early Administration of Low Molecular Weight Heparin after Spontaneous Intracerebral Hemorrhage. A Safety Analysis. Cerebrovasc Dis, 27:146-150.(IF 2.53) [drafting or revising critically important intellectual content] 137. Kerling F, Dütsch M, Linke R, Kuwert T, Stefan H, Hilz MJ (2009) Relation between ictal asystole and cardiac sympathetic dysfunction shown by MIBG-SPECT Acta Neurol Scand, 120:1213-9 (IF 1.71) 138. Stirban A, Laude D, Elghozi JL, Sander D, Agelink MW, Hilz MJ, Ziegler D (2009) Acute effects of Sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in Type 2 diabetic patients. Diabetes Metab Res Rev, 25:136-45 (IF 3.37) [drafting or revising critically important intellectual content] 139. Bickel A, Heyer G, Senger C, Maihoefner C, Heuss D, Hilz MJ, Namer B (2009) C-fiber axon reflex flare size correlates with epidermal nerve fiber density in human skin biopsies. J Peripher Nerv Syst, 14:294-9. (IF 2.80) [Data interpretation, drafting or revising critically important intellectual content] 140. Strothotte S, Strigl-Prill N, Grunert B, Kornblum C, Eger K, Wessig C, Deschauer M, Breunig F, Glocker FX, Vielhaber S, Brejova A, Hilz MJ, Reiners K, Müller-Felber W, Mengel E, Spranger M, Schoser B (2010) Enzyme replacement therapy with alglucosidase alfa in 44 patients with late-onset glycogen storage disease type 2: 12-month results of an observational clinical trial. J Neurol, 257:91-7 (IF 3.14) [drafting or revising critically important intellectual content] 141. Axelrod FB, Hilz MJ, Berlin D, Yau PL, Javier D, Sweat V, Bruehl H, Convit A (2010) Neuroimaging supports central pathology in familial dysautonomia J Neurol, 257:198-206 (IF 3.14) [Conception and design of Study, Data analysis and interpretation, drafting or revising critically important intellectual content] 142. Giannini EH, Mehta AB, Hilz MJ, Beck M, Bichet DG, Brady RO, West M, Germain DP, Wanner C, Waldek S, Clarke JT, Mengel E, Strotmann JM, Warnock DG, Linhart A (2010) A validated disease severity scoring system for Fabry disease. Mol Genet Metab, 99:283-90. (IF 2.94) [drafting or revising critically important intellectual content] 143. Cimaz R, Guillaume S, Hilz MJ, Horneff G, Manger B, Thorne JC, Møller AT, Wulffraat NM, Roth J (2010) Awareness of Fabry disease among rheumatologist – current status and perspectives. Clin Rheumatol, 30:467-75 (IF. 1.55) [drafting or revising critically important intellectual content] 144. Hilz MJ, Marthol H, Schwab S, Kolodny EH, Brys M, Stemper B (2010) Enzyme replacement therapy improves cardiovascular responses to orthostatic challenge in Fabry patients. J Hypertens, 28:1438-1448 (IF 5.13) 145. Marthol H, Intravooth T, Bardutzky J, De Fina P, Schwab S, Hilz MJ (2010) Sympathetic cardiovascular hyperactivity precedes brain death. Clin Auton Res, 20:363-9 (IF 1.51) 146. Kulesh SD, Filina NA, Frantava NM, Zhytko NL, Kastsinevich TM, Kliatskova LA, Shumskas MS, 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 10 / 22 Curriculum vitae Max Hilz Hilz MJ, Schwab S, Kolominsky-Rabas PL (2010) Incidence and Case-Fatality of Stroke on the East Border of the European Union. The Grodno Stroke Study. Stroke, 41:2726-30 (IF 7.04) [Data interpretation, drafting or revising critically important intellectual content] 147. Hilz MJ, DeFina P, Anders S, Koehn J, Lang CJ, Pauli E, Flanagan S, Schwab S, Marthol H (2011) Frequency analysis reveals subtle cardiac autonomic dysfunction in patients with mild traumatic brain injury. J Neurotrauma. 28:1727-38 (IF 4.25) 148. Hilz MJ, Moeller S, Akhundova A, Marthol H, Pauli E, DeFina P, Schwab S (2011) High NIHSS values predict impairmant of cardiovascular autonomic control. Stroke, 42:1528-33 (IF 7.04) 149. Kulesh SD, Kastsinevich TM, Kliatskova LA, Sauchanka ME, Filina NA, Shumskas MS, Schwab S, Hilz MJ, Kolominsky-Rabas PL (2011) Long-term outcome after stroke in Belarus: The Grodno Stroke Study. Stroke, 42:3274-6 (IF 7.04) [Data interpretation, drafting or revising critically important intellectual content] 150. Wagner I, Volbers B, Hilz MJ, Dörfler A, Schwab S, Staykov D (2012) Radiopacity of intracerebral hemorrhage correlates with perihemorrhagic edema. Eur J Neurol, 19:525-8 (IF 1.16) [Data interpretation, drafting or revising critically important intellectual content] 151. Hilz MJ, Koehn J, Kolodny Eh, Brys M, Moeller S, Stemper B (2011) Metronomic breathing shows altered parasympathetic baroreflex function in untreated Fabry patients and baroreflex improvement after enzyme replacement therapy. J Hypertens, 29:2387-94 (IF 3.98) 152. Üçeyler N, He L, Schönfeld D, Kahn AK, Reiners, K, Hilz, M, Breunig, F, Sommer, C (2011) Small fibers in Fabry disease: baseline and follow-up data under enzyme replacement therapy. J Peripher Nerv Syst, 16:304-14 (IF 3.03) [Data interpretation, drafting or revising critically important intellectual content] 153. Moeller S, Hilz MJ, Blinzler C, Koehn J, Doerfler A, Schwab S, Köhrmann M (2012) Extracranial Internal Carotid Artery Vasospasm due to Sympathetic Dysfunction. Neurology, 78:1892-4 (IF 8.25) [Data interpretation, drafting or revising critically important intellectual content] 154. Hilz MJ, Ehmann E, Pauli E, Baltadzhieva R., Koehn J, Moeller S, DeFina P, Axelrod F (2012) Combined counter-maneuvers accelerate recovery from orthostatic hypotension in Familial Dysautonomia. Acta Neurol. Scand, 126:162-70 (IF 2.47) 155. Koehn J, Kollmar R, Cimpianu CL, Kallmünzer B, Moeller S, Schwab S, Hilz MJ (2012) Head and Neck Cooling Decreases Tympanic and Skin Temperature, But Significantly Increases Blood Pressure. Stroke, 43:2142-8 (IF 6.83) 156. Hilz MJ, Koehn J, Tillmann A, Riss S, Marthol H, Köhrmann M, Wasmeier G, Schwab S, Stemper B (2013) Autonomic blockade during sinusoidal baroreflex activation proves sympathetic modulation of cerebral blood flow velocity. Stroke, 44: 1062-9 (IF 6.83) 157. Breuer L, Huttner HB, Kiphuth IC, Ringwald J, Hilz MJ, Schwab S, Köhrmann M (2013) Waiting for platelet counts causes unsubstantiated delay of thrombolysis therapy. Eur Neurol, 69:317-20 (IF 1.50) [Data interpretation, drafting or revising critically important intellectual content] 158. Hilz MJ, Stadler P, Gryc T, Juliane Nath J, Habib-Romstoeck L, Stemper B, Buechner S, Wong S, Koehn J (2014) Music induces different cardiac autonomic arousal effects in young and older persons. Autonomic Neuroscience: Basic and Clinical, 183: 83-93 (IF 1.85) 159. Kallmünzer B, Bobinger T, Kahl N, Kopp M, Kurka N, Hilz MJ, Marquardt L, Schwab S, Köhrmann M (2014) Peripheral pulse measurement after ischemic stroke: A feasibility study. Neurology, 83:5 98-603 (IF 8.30) [Data interpretation, drafting or revising critically important intellectual content] 160. Winder K, Seifert F, Ohnemus T, Sauer EM, Kloska S, Dörfler A, Hilz MJ, Schwab S, Köhrmann M (2015) Neuroanatomic correlates of poststroke hyperglycemia. Ann Neurol. 2015 Feb;77(2):262-8 (IF 11.91) [Data interpretation, drafting or revising critically important intellectual content] 161. Seifert F, Kallmünzer B, Gutjahr I, Breuer L, Winder K, Kaschka I, Kloska S, Doerfler A, Hilz MJ, Schwab S, Köhrmann M (2015) Neuroanatomical correlates of severe cardiac arrhythmias in acute ischemic stroke. J. Neurology, 262:1182-90 [IF 3.841] [Data interpretation, drafting or revising critically important intellectual content] 162. Bobinger T, Kallmünzer B, Kopp M, Kurka N, Arnold M, Hilz MJ, Hagen B. Huttner HB, Schwab S, Köhrmann M (2015) Prevalence and impact on outcome of electrocardiographic early repolarization patterns among stroke patients. A prospective observational study. Clinical Research in Cardiology, 104:666-71 (IF:4.2) [Data interpretation, drafting or revising critically important intellectual content] 163. Hilz MJ., Intravooth T, Moeller S, Wang R, Lee DH, Koehn J, Linker RA (2015) Central autonomic dysfunction delays recovery of Fingolimod induced heart rate slowing. PLoS One, 2015 Jul 6;10(7):e0132139. doi: 10.1371/journal.pone.0132139. eCollection 2015. (IF=3.534) [Data 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 11 / 22 Curriculum vitae Max Hilz interpretation, drafting or revising critically important intellectual content] 164. Hilz MJ, Aurnhammer F, Flanagan SR, Intravooth T, Wang R, Hösl KM, Pauli E, Koehn J (2015) Eyeball pressure stimulation unveils subtle autonomic cardiovascular dysfunction in persons with a history of mild traumatic brain injury. Journal of Neurotrauma, 2015 Sep 23. [Epub ahead of print] [IF 3.714] [Data interpretation, drafting or revising critically important intellectual content] 165. Koehn J, Crodel C, Deutsch M, Kolominsky-Rabas PL, Hösl KM, Köhrmann M, Schwab S, Hilz MJ (2015) Erectile Dysfunction (ED) after ischemic stroke - association between prevalence and site of lesion. Clin Auton Res, 2015 Sep 15. [Epub ahead of print] [IF 1.487] [Data interpretation, drafting or revising critically important intellectual content] 166. Kallmünzer B, Bobinger T, Kopp M, Kurka N, Arnold M, Hilz MJ, Schwab , Köhrmann M (2015) Impact of heart rate dynamics on mortality in the early phase after ischemic stroke: a prospective observational trial. J Stroke Cerebrovasc Dis, 24: 946-51 [IF 1.669] [Data interpretation, drafting or revising critically important intellectual content] 167. Winder K, Seifert F, Koehn J, Deutsch M, Engelhorn T, Dörfler A, Lee D.H., Linker R.A., and Hilz M.J (2015) Site and Size of Multiple Sclerosis Lesions Predict Enhanced or Decreased Female Orgasmic Function. [in press] [IF 3.841] Other Peer Reviewed Publications 168. Neundörfer B, Druschky A, Hilz MJ (1997) Paraneoplastic syndromes of the central and peripheral nervous system as well as the musculature. Neurology, Psychiatry and Brain Res, 5:15-20 (IF: 0.10) [Conception and design of Study, drafting or revising critically important intellectual content] 169. Heckmann JG, Mück-Weymann M, Hilz MJ, Claus D, Neundörfer B (1997) Die transkranielle Doppler-sonographie unter Ergometerbelastung: Methodik und Fallbeispiele. Akt Neurol, 24: 9-83 (IF 0.33) [Conception and design of Study, drafting or revising critically important intellectual content] 170. Neundörfer B, Hilz MJ (1998) Ludwig Robert Müller (1870-1962) - a pioneer of autonomic nervous system research. Clin Auton Res, 8: 1-5 (IF 0.83) [Conception and design of Study, drafting or revising critically important intellectual content] 171. Hilz MJ, Dütsch M, Neundörfer B (1998) Autonome Störungen bei Polyneuropathien. Med Klinik, 93:533-40 (IF 0.47) 172. Lang C, Hilz MJ (1998) Neurologische Expertise wünschenswert. Dtsch. Ärzteblatt, 37:A2268A2269 [Conception and design of Study, drafting or revising critically important intellectual content] 173. Hilz MJ, Stemper B (1998) Staging der diabetischen Neuropathie. Nervenheilkunde,17:424-29 (IF 0.45) 174. Hecht M, Hilz MJ. (1998) Neurophysiologische Befunde der diabetischen Neuropathie: Neurographie, Elektromyographie, Vibratometrie, Thermotestung. Nervenheilkunde, 17:430-36 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 175. Stemper B, Hilz MJ (1998) Autonome diabetische Neuropathie: kardiale und peripher-autonome Befunde. Nervenheilkunde, 17:437-43 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 176. Zahner B, Hilz MJ (1998) Abgrenzung des Karpaltunnelsyndroms gegenüber der Polyneuropathie bei Diabetes mellitus. Nervenheilkunde, 17:444-51 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 177. Zahner B, Hilz MJ (1998) Therapiemöglichkeiten der diabetischen Polyneuropathie - ein Ausblick. Nervenheilkunde, 17:452-57 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 178. Heckmann JG, Hilz MJ, Brandt-Pohlmann M, Hecht M, Neundörfer B (1998) Aktueller Stand der Diagnostik des offenen Foramen ovale. Nervenheilkunde, 17:458-60 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 179. Hilz MJ, Dütsch M, Kölsch C (1999) Epilepsie und autonome Störungen. Fortschr Neurol Psychiat, 67:49-59 (IF 0.75) 180. Neundörfer B, Hilz MJ (1999) Störungen des autonomen Nervensystems. Akt Neurol, 26:49-54 (IF 0.33) [Conception and design of Study, drafting or revising critically important intellectual content] 181. Hilz MJ (1999) Neurodiagnostic procedures used in the diagnosis of erectile dysfunction. Clin Auton Res, 9:291-93 (IF 0.83) 182. Hecht M, Hilz MJ, Neundörfer B (2000) Somatosensibel evozierte Potentiale nach Stimulation 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 12 / 22 Curriculum vitae Max Hilz des N. trigeminus in der Diagnostik von Hirnstammläsionen. Nervenheilkunde, 19:247-51 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 183. Hecht M, Hilz MJ (2000) Differenzierung von Verschlüssen der Arteria carotis interna gegenüber Pseudookklusionen – Sind sonographische Methoden ausreichend, um einen Verschluß sicher zu diagnostizieren? Nervenheilkunde, 19:220-25 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 184. Heckmann JG, Hilz MJ, Mück-Weymann M, Neundörfer B (2000) Funktionelle transkranielle Dopplersonographie. Nervenheilkunde, 19:242-46 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 185. Hilz MJ, Kölsch C, Marthol H, Neundörfer B (2000) Engpaßsyndrome der oberen Extremitäten. Nervenheilkunde, 19:226-36 (IF 0.45) 186. Horn S, Hilz MJ (2000) Sympathische Hautantwort - Ableitetechnik und Befundinterpretation. Nervenheilkunde, 19: 264-70 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 187. Bickel A, Hilz MJ (2000) Der quantitative Sudomotor-Axonreflextest. Nervenheilkunde, 19:259-63 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 188. Hilz MJ, Stemper B, Neundörfer B (2000) Physiologie und Untersuchungsmethoden des Baroreflexes. Fortschr Neurol Psychiat, 68:37-47 (IF 0.75) 189. Hilz MJ, Hecht M, Kölsch C (2000) Erektile Dysfunktion. Akt Neurol, 27:1-12 (IF 0.33) 190. Erxleben H, Hilz MJ (2000) Neurophysiologische Hirnstammdiagnostik mittels Blinkreflex, Masseterreflex und Kieferöffnungsreflex. Nervenheilkunde, 19:252-58. (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 191. Neundörfer B, Hilz MJ (2000) Engpaßsyndrome der unteren Extremitäten. Nervenheilkunde,19:247-51. (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 192. Hilz MJ (2000) Praxisrelevante Fortbildung - ein Bindeglied zwischen Kliniken und niedergelassnen Nervenärzten. Editorial, Nervenheilkunde, 19: 217 (IF 0.45) 193. Hilz MJ, Marthol H, Neundörfer B (2000) Diabetische somatische Polyneuropathie Pathogenese, klinische Manifestationsformen u:Therapie-Konzepte. Fortschr Neurol Psychiat, 68:278-85 (IF 0.75) 194. Hilz MJ, Stemper B, Heckmann JG, Neundörfer B (2000) Mechanismen der zerebralen Autoregulation, Untersuchungsverfahren und Beurteilung mittels transkranieller Dopplersonographie. Fortschr Neurol Psychiat, 68:398-412 (IF 0.75) 195. Heckmann JG, Erbguth FJ, Hilz MJ, Lang CJG, Neundörfer B (2001) Die Hirndurchblutung aus klinischer Sicht. Historischer Überblick, Physiologie, Pathophysiologie, diagnostische und therapeutische Aspekte. Med Klin, 96:583-92 (IF 0.47) [Conception& design of Study, revising critically important intellectual content] 196. Hecht MJ, Bickel A, Neundörfer B, Hilz MJ (2001) Elektrophysiologische Diagnostik des GuillainBarré-Syndroms und der chronisch-imflammatorischen demyelinisierten Polyneuropathie. Nervenheilkunde, 20:486-90 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 197. Bickel A, Neundörfer B, Hecht MJ, Hilz MJ (2001) Die multifokal-motorische Neuropathie. Nervenheilkunde, 20:491-98 (IF 0.45) [Conception and design of Study, drafting or revising critically important intellectual content] 198. Dütsch M, Hilz MJ, Neundörfer B (2001) Klinik und Diagnose der diabetischen autonomen Neuropathie. Fortschr Neurol Psychiat, 69:423-38 (IF 0.75) [Conception and design of Study, drafting or revising critically important intellectual content] 199. Hilz MJ (2002) Erektile Dysfunktion. Münchener Medizinische Wochenschrift, 7:41-44 200. Hilz MJ (2002) Assessment and evaluation of hereditary sensory and autonomic neuropathies with autonomic and neurophysiological examinations. Clin Auton Res, 12, Suppl. 1:I/33-I/43 (IF 0.83) 201. Hilz MJ, Marthol H, Neundörfer B (2002) Synkopen – eine systematische Übersicht zur Klassifikation, Pathogenese, Diagnostik und Therapie. Fortschr Neurol Psychiat, 70:95-107 (IF 0.75) 202. Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K, Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O’Connor DT, Peltzer SR, Robert-son D, Rubin BY, Scudder Q, Smith LJ, Sonenshein GE, Svetjstrup, Xu Y, Slaugenhaupt SA (2003) Hereditary dysautonomias: current knowledge and collaborations for the future. Clin Auton Res, 13:180-95 (IF 0.83) [Conception and design of Study, drafting or revising critically important intellectual 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 13 / 22 Curriculum vitae Max Hilz content] 203. Hilz MJ. Marthol H (2003) Erektile Dysfunktion - Wertigkeit neurophysiologischer Diagnoseverfahren. Der Urologe, 10:1345-50 (IF: 0.44) 204. Marthol H, Hilz MJ (2004) Weibliche sexuelle Funktionsstörungen. Weibliche sexuelle Funktionsstörungen: Klassifikation, Diagnostik und Therapie. Fortschr Neurol Psychiatr, 72:121-35 (IF 0.75) [Conception and design of Study, drafting or revising critically important intellectual content] 205. Hilz MJ, Dütsch M (2005) Methoden zur quantitativen Untersuchung des autonomen Nervensystems. Der Nervenarzt, 76:767-78 (IF 0.89) 206. Hilz MJ, Dütsch M (2006) Quantitative studies of autonomic function. Muscle Nerve (invited review article) Muscle Nerve, 33:6-20 (IF 2.43) 207. Hilz MJ (2007). Peripheral nervous system involvement in Fabry disease: Role in morbidity and mortality. Clin Ther, 29:11-2 (IF 2.89) 208. Kohl B, Hülsemann W, Habenicht R, Hilz MJ, Stemper B, Püst B (2007) Hereditary sensory neuropathy type IV. Two case reports, Monatsschrift für Kinderheilkunde, 155:281-286 (IF: 0.23) [Conception and design of Study, drafting or revising critically important intellectual content] 209. Schaefer R, Szymanska AT, Hilz MJ (2009) Enzyme replacement therapy for Fabry disease: A systematic review of available evidence, Drugs, 69: 2179-205 (IF: 4.12) [Conception and design of Study, drafting or revising critically important intellectual content] 210. Dütsch M, Hilz MJ (2010) Neurological complications in Fabry Disease. Rev Med Interne, 31:243-250 [Conception and design of Study, drafting or revising critically important intellectual content] 211. Lahrmann H, Rocha I, Struhal W, Thijs RD, Hilz MJ (2011) Diagnosing autonomic nervous system disorders – existing guidelines and future perspectives. European Neurological Review, 6: 526 [Conception and design of Study, drafting or revising critically important intellectual content] 212. Burlina AP, Sims KB, Politei JM, Bennett GJ, Baron R, Sommer C, Møller AT, Hilz MJ (2011) Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel. BMC Neurology, 11:61 (IF 2.56) [Conception and design of Study, drafting or revising critically important intellectual content] 213. Sommer C, Üçeyler N, Thomas Duning T., Arning K, Baron R, Brand E, Canaan-Kühn S, Hilz MJ, Naleschinski D, Wanner C, Weidemann F. (2012) Pain Therapy in Fabry’s disease Schmerztherapie bei Morbus Fabry. Internist (Berl), 54:121-2, 124-30. [Conception and design of Study, drafting or revising critically important intellectual content] 214. Kolodny E, Fellgiebel A, Hilz MJ, Sims K, Caruso P, Phan TG, Politei J, Manara R, Burlina A. (2015) Cerebrovascular Involvement in Fabry Disease: Current Status of Knowledge. Stroke, 46:302313 (IF 6.018) [Conception and design of Study, drafting or revising critically important intellectual content] 215. Maier A, Mannartz V, Wasmuth H, Trautwein Christian, Neumann UP, Weis J, Grosse J, Fuest M, Hilz MJ, Schulz JB, Haubrich C (2015) GAD Antibodies as Key-link between Chronic Intestinal Pseudoobstruction, Autonomic neuropathy, and Limb Stiffness in a Non-diabetic patient. Medicine. (accepted) (IF=5.723) 216. Hilz Max, Hoppe Ulrich, Möller Sebastian, Wang Ruihao, Köhn Julia (2015) Can stapedius-reflex testing objectively measure muscle function in Pompe patients? Clinical Case Reports. (accepted) Invited Contributions 217. Cleeland CS, Hilz MJ (2002) Editorial Commentary. Acta Pediatr, 91(Suppl):33 (IF 1.14) [Conception and design of Study, drafting or revising critically important intellectual content] 218. Hilz MJ (2002) Evaluation of peripheral and autonomic nerve function in Fabry disease. Acta Pediatr (invited review), 91(Suppl):38-42 (IF 1.14) 219. Axelrod F, Hilz MJ (2003) Inherited autonomic neuropathies. Semin Neurol, 4:381-90 (IF 1.04) [Conception and design of Study, drafting or revising critically important intellectual content] 220. Lahrmann H, Cortelli P, Hilz MJ, Mathias C, Struhal W, Tassinari M (2006) EFNS Task Force EFNS guidelines on the diagnosis and management of orthostatic hypotension. Eur J Neurol, 13:9306 (IF 2.22) [Conception and design of Study, drafting or revising critically important intellectual content] 221. Hilz MJ, Schwab S (2008) Stroke induced sudden-autonomic death: areas of fatality beyond the insula. (Editorial) Stroke, 39:2421-2 (IF 6.29) 222. D. Ziegler D, Haslbeck M, Neundörfer B, Luft D, Bierwirth R, Forst T, Hilz M, Jacob S, Keller J, 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 14 / 22 Curriculum vitae Max Hilz Lobmann R, Pannek J (2010) Diabetische Neuropathie, S1 Leitlinie der Deutschen Diabetes Gesellschaft Diabetologie 5: S1–S10. [Conception and design of Study, drafting or revising critically important intellectual content] 223. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schondorff R, Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci, 161:46-8 (IF1.67) [Conception and design of Study, drafting or revising critically important intellectual content] 224. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schondorff R, Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res, 21:69-72 (IF 1.27) [Conception and design of Study, drafting or revising critically important intellectual content] 225. Hilz MJ (2012) Autonome Komplikation nach Schaganfall. Neurologisch 1/12:88-89 226. Hilz MJ, Hoppe Ulrich, Moeller S, Wang R and Koehn J (2015) Can stapedius reflex testing objectively measure muscle function in Pompe patients? Clinical Case Reports, doi: 10.1002/ccr3.400 MEDIA RESOURCE EDUCATIONAL MATERIALS Hilz, MJ. Autonomic Neurology. in M.A. Samuels (ed.): "Comprehensive Review of Neurology" Oakstone Medical Publishing, 30 Audio CDs; 08, 31, 2009 Book Chapters 1. Druschky KF, Pfurtscheller G, Hilz MJ, Wack P, Neundörfer B, Litscher G, Brinkmann HG (1988) Multimodale elektrophysiologische Komaskala (MECS) als prognostisches Kriterium bei Hirnstammprozessen. In: Bogdahn U, Mertens HG, eds. Prognostik in der Intensivtherapie des Zentralnervensystems. Berlin-New York: Springer, 290-6 2. Hilz MJ, Druschky KF, Huk W, Brinkmann H (1988) Zieve-Syndrome - a risk factor in the pathogenesis of intra-cranial hemorrhages? In: Bartko D, ed. Modern Trends in Neurology & Neurological Emergencies. Prag, 217-8 3. Hilz MJ, Höll R, Weidenhammer W, Mösler TA, Lungershausen E (1989) Attitudes of medical staffs towards suicide patients. In: Stefanis CN, Soldatos CR, Rabavilas AD, eds. Psychiatry today, Accomplishments and promises, VIII World Congress of Psychiatry. Amsterdam: Elsevier, 106 4. Hilz MJ, Schellmann B, Sörgel F (1989) Fatal Complications after Intrathecal Application of Megluminamidotrizoat. In: Proceedings of the Second Meeting of the International Neurotoxicology Association. Barcelona: Graficas Campas, 252 5. Hilz MJ, Druschky KF, Höll R, Wagner S, Ostermann N, Weidenhammer W (1991 Komaskalen im Vergleich. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurologischer Intensivmedizin, Bd. 19, Erlangen: Perimed, 112-7 6. Hilz, MJ, Druschky KF, Weis M, Litscher G, Pfurtscheller G, Neundörfer B (1991) Kontinuierliches multiparametrisches Neuromonitoring - Erste Erfahrungen. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurolog. Intensivmedizin, Bd 19, Erlangen: Perimed, 124-8 7. Hilz MJ, Rudel H, Druschky KF (1991) Dekubitustherapie mit einem Air-Fluidized-Bett bei einem Patienten mit Hypercortisolismus und chronsich idiopathischer Polyneuroradikulitis. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurol. Intensivmedizin, Bd 19, Erlangen: Perimed, 162-5 8. Hilz MJ, Claus D, Rösl G, Neundörfer B, Sterzel RB (1991) Einfluß der Hämodialyse auf Temperatur- und Vibratometrieschwellen bei chronisch terminaler Niereninsuffizienz. In: Firnhaber W, Dworschak K, Lauer K, Nichtweiß M, eds. Verhandlungen der DGN, Bd 6, Berlin: Springer, 638-9 9. Brinkmann HG, Bauer J, Druschky KF, Erbguth F, Hilz MJ, Stefan H (1991) Protrahierter Status epilepticus komplex-partieller Anfälle. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurologischer Intensivmedizin, Bd. 19, Erlangen: Perimed, 97-9 10. Erbguth F, Hilz MJ, Druschky KF, Neundörfer B (1991) Bilaterale Infarzierungen von Thalamus und Stammganglien bei Thrombosen der inneren Hirnvenen. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwerpunkte neurol. Intensivmedizin, Bd. 19, Erlangen: Perimed, 189-93 11. Erbguth F, Hilz MJ, Rechlin T, Weis M, Claus D (1991) Diagnostische und therapeutische Probleme bei Listerien-Meningoenzephalitiden. In: Huffmann G, Braune W, eds. Infektionskrankheiten 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 15 / 22 Curriculum vitae Max Hilz des Nervensystems, Reinbeck: Einhorn, 223-32 12. Höll R, Hilz MJ, Druschky KF, Brinkmann HG, Grahmann F, Stefan H, Neundörfer B (1991) Status myoclonicus bei einem Patienten mit einer nicht klassifizierbaren progressiven Myoklonusepilepsie. In: Druschky KF, Erbguth F, Neundörfer B, eds. Notfallmedizin, Schwer-punkte neurologischer Intensivmedizin, Notfallmedizin, Band 19, Erlangen: Perimed, 104-6 13. Litscher G, Schwarz G, Pfurtscheller G, Hilz MJ, Lechner A, List WF (1991) Neuromonitoring in critical care medicine. In: Proceedings of the Internat. Munich Symposium on advanced Critical Care Monitoring, E17.1-2 14. Hilz MJ, Claus D, Neundörfer B (1992) "Marstock"-Thermotestung - eine Bereicherung in der Diagnostik von Polyneuropathien. In: Huffmann G, Braune HJ, eds. Läsionen des peripheren Nervensystems. Reinbeck: Einhorn, 115-21 15. Zahner B, Stefan H, Feistel H, Hilz MJ, Harrer M, Neundörfer B (1992) Verlaufsuntersuchungen zur akuten bakteriellen Meningitis/ Meningoencephalitis. In: Schimrigk K, Haaß A, Hamann G, eds. Verhandlungen der Dtsch. Ges. f. Neurologie. Vol. 7, Zweibrücken: Conrad & Bothner, 602-4 16. Hilz MJ, Erbguth F, Weis M, Faatz U, Claus D, Neundörfer B (1992) Wertigkeit von Koma-Skalen für eine frühe Beurteilung der Prognose. In: Schimrigk K, Haaß A, Hamann G eds. Verhandlungen der Dtsch. Ges. für Neurologie. Vol. 7, Zweibrücken: Conrad & Bothner, 545-7 17. Erbguth F, Friedel A, Hilz MJ, Kilian KD, Rechlin T, Claus D, Neundörfer B (1992) Botulinus-ToxinInjektionen bei zervikalen Dystonien: Probleme der Therapiekontrolle bei Verlaufs-untersuchungen. In: Schimrigk K, Haaß A, Hamann G, eds. Verhandlungen der DGN. Vol. 7, Zweibrücken: Conrad & Bothner, 111-3 18. Neundörfer B, Hilz MJ (1994) Die Bedeutung von Anamnese und klinisch-neurologischem Untersuchungsbefund für das Neuromonitoring in Anästhesie und Intensivtherapie. In: Rügheimer E, Dinkel M, eds. Neuromonitoring in Anästhesie und Intensivmedizin, Berlin: Springer, 43-51 19. Hilz MJ, Neuner I, Glorius S, Schweibold G, Axelrod F, Kolodny EH (1995) Quantitative Thermotestung als Indikator kardialer autonomer Gefährdung bei Familiärer Dysautonomie. In: Jerusalem F, Ries F, eds. Verhandlungen der DGN. Vol. 8, Bonn, Köllen Druck & Verlag, 475-7 20. Hilz MJ (1997) Autonome Störungen bei Polyneuropathien. In: Diener HC, Felgenhauer K, Reichmann H, Wallesch CW, Wiegand F, eds. Akt. Neurol, Sonderband. DGN ´97, Stuttgart, Thieme, E5-1 - 10 21. Heckmann JG, Mück-Weymann M, Hilz MJ, Claus D, Neundörfer B (1998) Transcranial Doppler sonography under ergometer stress suggests diminished sympathetic cerebrovascular activity in tension type headache. In: Blazek V, Schulz-Ehrenburg U, eds. Frontiers in computer-aided visualization of vascular functions. VDI-Verlag, Düsseldorf, 165-8 22. Hilz MJ (1998) Testing of peripheral and vascular autonomic function. In: Stalberg EV, DeWeerd AW, Zidar J, eds.9th European Congress of Clin. Neurophysiology, Monduzzi Editore Bologna; 165-72 23. Hilz MJ (1998) Erektile Dysfunktion. In: Brandt, Th, Diener HC, Felgenhauer K, Wallesch CW, Wiegand F, eds: Akt Neurol, Sonderband. DGN ´98, Thieme Stuttgart, I51-8 24. Heckmann JG, Mück-Weymann M, Hilz MJ, Katalinic A, Neundörfer B (1999) Autoregulative response of cerebral vessels to elevation in arterial blood pressure: a study using stress TCD. In: Blazek V, Schulz-Ehren-burg U, eds. Frontiers in computer-aided visualization of vascular functions. VDI-Verlag, Düsseldorf, 109-12 25. Heckmann JG, Hilz MJ, Russo H, Hagler A, Mück-Weymann M, Neundörfer B (1999) Transcranial Doppler Sonography during acute 80 degree Head-Down Tilt (HDT) for the Assessment of Cerebral Autoregulation in Humans. In: Blazek V, Schulz-Ehrenburg U, eds. Frontiers in computer-aided visualization of vascular functions. VDI-Verlag, Düsseldorf, 105-8 26. Hilz MJ (1999) Neurologische und neurophysiologische Aspekte der erektilen Dysfunktion. In: Wallesch CW, Diener HC, Felgenhauer K, Wiegand F, eds: Akt Neurol, Sonderband. Dtsch. Ges. für Neurologie ´99, Thieme Stuttgart, C3-1 –10 27. Dütsch M, Hilz MJ, Rauhut U, Neundörfer B, Axelrod FB (2000) Baroreflex dysfunction contributes to the occurence of orthostatic hypotension in familial dysautonomia. In: Haupt WF, Grond M, Halber M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der Arbeitsgemeinschaft Neurologische Intensivmedizin (ANIM). Shaker, Aachen, 74-5 28. Hecht M, Hilz MJ, Kiesewetter F, Neundörfer B (2000) Verbesserte ätiologische Zuordnung der erektilen Dysfunktion bei Diabetikern durch neurologisch-neurophysiologische Untersuchung. In: Haupt WF, Grond M, Halber M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der Arbeitsgemeinschaft Neurologische Intensivmedizin (ANIM). Shaker, Aachen, 74 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 16 / 22 Curriculum vitae Max Hilz 29. Singer W, McPhee BR, Opfer-Gehrking TL, Hilz MJ, Low PA (2000) Orale Pyridostigmin-Gabe eine neue Strategie in der Behandlung der orthostatischen Hypotonie. In: Haupt WF, Grond M, Halber M, eds. Neurologische Intensivmedizin: 17. Jahrestagung der Arbeitsgemeinschaft Neurologische Intensivmedizin (ANIM). Shaker, Aachen, 76 30. Hilz MJ (2001) Synkopen, Klassifikation, Pathogenese und Diagnose. In: Noth J, Diener HC, Felgenhauer K., Wallesch CW, Busch E, eds.: Akt Neurol. 1998, Sonderband. Dtsch. Ges. für Neurologie 2001. Thieme Stuttgart; 349-52 31. Heckmann JG, Heckmann SM, Hummel T, Popp M, Marthol H, Neundörfer B, Hilz MJ (2001) Oral mucosa blood flow following dry ice stimulation in humans. In: Blazek V, Schulz-Ehrenburg U, Stvrtinová V (eds.): Proceedings, 9th Intern. Symposium CNVD. Wissenschaftsverlag Mainz, Aachen, 135-8 32. Dütsch M., Hilz MJ (2004) Pathophysiologie und Diagnose der Schmerzsymptome bei M. Fabry. In: Wanner C, ed: Morbus Fabry: Klinik, Diagnostik & Therapie, UNI-MED Verlag, Bremen, 50-60 33. Hilz MJ (2005) Klinische Symptome zentraler und peripherer autonomer Störungen am Beispiel der diabetischen autonomen Neuropathie und des GBS. Fortbildungsakademie der 78. Jahrestagung der Deutschen Gesellschaft für Neurologie. Hrsg. Oertel WH, Diener HC, Busch E. Akt Neurol, Sonderband Dtsch. Ges. für Neurologie, Thieme Stuttgart, 582-583 34. Hilz, MJ (2006) Basic principles of autonomic nervous function together with a classification of key autonomic disorders and clinical features of dysautonomia; Syllabus, Teaching Course 9: Disorders affecting the autonomic nervous system - clinical evaluation, investigation and treatment. http.//www.efns.org/content.php?pid=169#ans, 1-25 35. Hilz MJ (2006) Klinische und apparative Untersuchung autonomer Störungen bei Diabetes. Fortbildungsakademie der 79. Jahrestagung der Deutschen Gesellschaft für Neurologie. Hrsg. Hennerici MG, Weiller C, Diener HC, Busch E. Akt Neurol, Sonderband Dtsch. Ges. für Neurologie, Thieme Stuttgart 226-229 36. Hilz MJ (2007) Diagnostik und Therapie autonomer Störungen. In: Einhäupl KM, Weiller C, Diener HC, Busch EW, eds.: Akt Neurologie 2007, Sonderband. Dtsch. Ges. für Neurologie, Thieme Stuttgart; 91-94 37. Hilz MJ, Marthol H (2008) Physiologic changes of autonomic nervous system function during sleep. Sonderband Dtsch. Ges. für Neurologie Thieme Stuttgart 593-597 38. Hilz MJ, Marthol H (2008) Autonomic Disorders in Guillain-Barré Syndrome and Diabetic Neuropathy: Pathophysiology, Clinical Relevance and Management. EFNS 2008; Autonomic disorders in neurology: diagnosis and management 39. Hilz MJ (2013). Autonomic Nervous System. In: Runehov, Anne; Oviedo, Lluis, eds.: Encyclopedia of Sciences and Religions, Springer; Springer Netherlands. pp 180-182 Handbook chapters: 40. Hilz MJ (1996) Läsionen des Plexus brachialis und des Plexus lumbosacralis. In: Neundörfer B, Schneider E, Dittmann V, Pöldinger W,eds. Atlas der Nervenheilkunde, G. Braun, Karlsruhe, 86-92 41. Hilz MJ (1999) Autonome Störungen. In: Kukowski B., Hrsg: Differentialdiagnose neurologischer Symptome. Tabellen und Übersichten für eine schnelle und sichere Diagnosestellung. Thieme, Stuttgart New York, 348-68 42. Axelrod FB, Hilz MJ (2000) Familial dysautonomia. In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology. Elsevier, Amsterdam, The Netherlands, Volume 75 (31), 143-60 43. Hilz MJ (2000) Erectile dysfunction – diagnostic approach and treatment options. In: Ambler Z, Nevšímalová S, Kadaňka Z, Rossini PM. eds.: Clinical Neurophysiology at the Beginning of the 21st Century, Elsevier Amsterdam, Lausanne, 234-6 44. Hilz MJ (2001) Alteraciones del sistema nervioso autónomo. In: Kukowski B., Hrsg: Tablas y resúmes sinópticos para un diagnóstico rápido y seguro. Masson S.A. Barcelona, 361-82 45. Hilz MJ (2002) Quantitative autonomic functional testing in clinical trials. In: Brown WF, Bolton CF, Aminoff MJ, eds.: Neuromuscular Function and Disease. Basic, clinical and electrodiagnostic aspects. WB Saunders, Philadelphia, USA, Volume 2; 1899-929 46. Hilz MJ, Stemper B, Koeppen S, Diehl RR (2002) Neurogene Synkopen. Leitlinien für Diagnostik und Therapie in der Neurologie. In Diener HC, Hrsg: Leitlinien der Dtsch. Ges. für Neurologie, Thieme, Stuttgart, 276-77 47. Axelrod FB, Hilz MJ (2004) Familial Dysautonomia. In: Robertson D, Low PA, Polinsky RJ, eds.: Primer on the Autonomic Nervous System, 2nd Ed., Academic Press San Diego, New York, 312-15. 48. Hilz MJ, Ziemssen T (2005) Autonome Störungen. In: Wallesch CW (Hrsg): Neurologie – 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 17 / 22 Curriculum vitae Max Hilz Diagnostik und Therapie in Klinik und Praxis, Urban & Fischer, München, Jena 327-38. 49. Sander D, Hilz MJ, Ziemssen T (2008) Autonome Störungen und vegetative Krisen. In: Schwab S, Unterberg A, Werner, Hacke W, Neurologische Intensivmedizin. Springer, Heidelberg 642-660. 50. Jost W, Braune S, Derouet H, Kessler TM, Kiss G, Haensch CA, Hilz MJ. (2008) Diagnostik und Therapie der erektilen Dysfunktion. In: Diener HC, Putzki N. (ed): Leitlinien für Diagnostik und Therapie in der Neurologie (Guidelines for diagnostic and therapy in neurology. Thieme, Stuttgart 4. Auflage. 51. Berlit P., Diehl R.R., Hilz M.J., Schuchert A., Steinhoff B., Herbst H., Humm A., Wenning G. K. (2008) Synkopen. In:Diener H.C., Putzki N. editors., Leitlinien für die Diagnostik und Therapie in der Neurologie. Thieme, Stuttgart 4. Auflage. 52. Low PA, Hilz MJ (2008). Diabetic Autonomic Neuropathy. In Low PA., Benarroch EE, eds.: Clinical Autonomic Disorders, Third Edition. Lippincott Williams & Wilkins, Philadelphia, 423-440 53. Hilz MJ (2008) . Female and Male Sexual Dysfunction. In Low PA., Benarroch EE, eds.: Clinical Autonomic Disorders, Third Edition. Lippincott Williams & Wilkins, Philadelphia , 657-711 54. Lahrmann H, Cortelli P, Hilz M, Mathias CJ, Struhal W, Tassinari M (2011) EFNS guidelines on the diagnosis and management of orthostatic hypotension. In: NE Gilhus, M Barnes, M. Brainin: European Handbook of Neurological Management, Vol 1. sec. ed., 469-475 55. Hilz MJ (2012). Physiology and Pathophysiolgy of female sexual function. In Robertson D, Biaggioni I, Burnstock G, Low PA, Paton JFR, eds. Primer of the Autonomic Nervous System, Academic Press, Oxford, 235-238 56. Dütsch M, Hilz MJ (2012). Epilepsy and autonomic control. In Robertson D, Biaggioni I, Burnstock G, Low PA, Paton JFR, eds. Primer of the Autonomic Nervous System, 3rd Ed. Academic Press, Oxford, 549-552 57. Jost W, Braune S, Derouet H, Kessler TM, Kiss G, Haensch CA, Hilz MJ (2012). Diagnostik und Therapie der erektilen Dysfunktion. In: Diener HC, Putzki N. (ed): Leitlinien für Diagnostik und Therapie in der Neurologie (Guidelines for diagnostic and therapy in neurology. Thieme, Stuttgart 5. Auflage. 58. Sander D, Hilz MJ, Ziemssen T (2015) Autonome Störungen und vegetative Krisen. In: Schwab S, Unterberg A, Werner, Hacke W (eds.): Neurologische Intensivmedizin. 2nd ed. Springer, Heidelberg; (in print). 59. Hilz MJ. (2015) Synkopen. In: Hacke W, Bendszus M., Ringleb P, Schwab S., Wick W (eds.): Lehrbuch der Neurologie, 14th ed.. Springer, Heidelberg, (in print) Non-Peer Reviewed Publications 1. Hilz MJ (1987) Schizoaffektive Psychosen und ihre Stellung in der Systematik psychiatrischer Krankheitsbilder. Nervenheilkunde, 6:164-70 (IF 0.45) 2. Bauer J, Müller RL, Hilz MJ, Stefan H (1989) Flugreisefähigkeit, Schutzimpfungen und Malariaprophylaxe bei Patienten mit Epilepsie. Epilepsie-Blätter, 2:13-17 [Conception and design of Study, drafting or revising critically important intellectual content] 3. Hilz MJ (1991) Arbeitstagung der Deutschen Gesellschaft für Neurologie (zusammenfassender Bericht). Akt Neurol; 18: XXV-XXIX. (IF 0.33) 4. Bauer J, Hilz MJ, Sappke U, Stefan H (1992) Klinische Symptomatologie und Therapie der Status epileptici. Fortschr Neurol Psychiat, 60:181-205 (IF 0.75) [Conception and design of Study, drafting or revising critically important intellectual content] 5. Claus D, Spitzer A, Hilz MJ (1992) Diagnose der peripheren diabetischen Polyneuropathie. Diabetes und Stoffwechsel, 1:34-41 [Conception and design of Study, drafting or revising critically important intellectual content] 6. Hilz MJ (1992) Exotoxische, metabolisch-toxische und hereditäre Polyneuropathien. Therapiewoche, 42:2896-904 7. Hilz MJ, Stefan H (1993) Klinisch-neurologische Untersuchung komatöser und bewußtseinsgetrübter Patienten. Therapiewoche, 43:16-21 8. Zahner B, Hilz MJ, Stefan H (1993) Akute Meningitis und Meningoenzephalitis, Diagnostik und Therapie. Therapiewoche, 43:33-37 [Conception and design of Study, drafting or revising critically important intellectual content] 9. Erbguth F, Stefan H, Hilz MJ (1993) Gerinnungshemmende Therapie bei Hirngefäßerkrankungen; Blutungsgefahr oder Prognoseverbesserung? Therapiewoche, 43:22-27[Conception and design of 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 18 / 22 Curriculum vitae Max Hilz Study, drafting or revising critically important intellectual content] 10. Hecht M, Hilz MJ (1999) Anatomie und Physiologie der Erektion – Pharmakotherapeutische Aspekte der erektilen Dysfunktion. EEG-Labor, 20:111-18 [Conception and design of Study, drafting or revising critically important intellectual content] 11. Hilz MJ (2000) Zusammenfassende Übersicht zu: Kardiosomatische Kopplung als differentieller Indikator für Komatiefe und Effektivität sensorischer Stimulation. (Hildebrandt H. Zieger A, Engel A, Kraft A.; Akt. Neurologie 1999: 26; 171-179); Review in Neurol. Intensivmed. Aktuell. 3. Jg., 1;34-36 12. Hilz MJ (2001) Eight years of professional experience with familial dysautonomia. Dyscourse, Spring /Summer 13. Dütsch M, Hilz MJ, Neundörfer B (2001) Autonome Neuropathie: Symptome, Diagnose und Behandlung. Der Bayerische Internist, 21:275-84 [Conception and design of Study, drafting or revising critically important intellectual content] 14. Hilz MJ (2002) Sexual Dysfunction: Diagnosis and Treatment. Neurol Croat, 51(Suppl 1):47-51 15. Dütsch M, Hilz MJ (2002) Diabetes Mellitus – die neurologische Sicht – Behandlung der Autonomen Polyneuropathie. Der Neurologe und Psychiater, 7-8;48-52 [Conception and design of Study, drafting or revising critically important intellectual content] 16. Hilz MJ. (2002) Erektile Dysfunktion nach Querschnittslähmung. Uro-News 17. Hecht M, Heuss D, Hilz MJ (2003) Diagnosis and treatment of polyneuropathy: what can the family doctor do? MMW Fortschr Med.145: Suppl 2:81-85. German. [Conception and design of Study, drafting or revising critically important intellectual content] 18. Hilz MJ (2003) International activities & symposia on clinical autonomic research. ANS News, 7:79 19. Marthol H, Hilz MJ, Dütsch M, Ziegler D (2007) Klinik, Diagnostik und therapie der autonomen Therapien - Klinische Symptomatik mit großer Bandbreite. Klinikarzt, 5:279-285 Projects 1. Autonomic evaluation of Familial Dysautonomia 2. Vascular dysregulation in Familial Dysautonomia 3. Development of autonomic testing methods 4. Standardization of quantitative sensory testing in children & adults 5. Add-on Study Protocol Nerve growth Factor in Diabetic Neuropathy 6. Cardiac autonomic dysfunction in patients with erectile dysfunction 7. Refined diagnosis of autonomic neuropathies 8. Clinical benefit of Midodrine HCl in patients with neurogenic orthostatic hypotension 9. Influence of epilepsy surgery on central autonomic cardiovascular control 10. Central autonomic regulation before and after epilepsy surgery 11. Development of neuro-physiologic methods evaluating autonomic dysfunction in erectile dysfunction 12. Influence of nerve growth factor (rhNGF) replacement therapy on diabetic neuropathy 13. Central autonomic dysfunction in Familial Dysautonomia 14. Autonomic dysfunction in Parkinson’s disease 15. Pathophysiology of Orthostatic Intolerance 16. Autonomic Nervous System and metabolic disorders 17. Orthostatic intolerance & central autonomic dysfunction in Familial Dysautonomia 18. Interaction of baroreceptor and chemoreceptor function and influence on cerebrovascular control in Familial Dysautonomia 19. Assessment of neuro-physiologic and auto-nomic effects of enzyme replacement in Fabry disease 20. Autonomic dysfunction in metabolic neuropathies 21. Assessing neurophysio-logic and autonomic effects of enzyme repla-cement in Fabry disease. 22. Variation in autonomic and small fiber function in normal subjects using repeated measurements 23. Efficacy of recombinant human -galactosidase replacement in patients with Fabry disease 24. Comparison of periphe-ral small fiber & post-ganglionic sudomotor function in hereditary 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 19 / 22 Curriculum vitae Max Hilz neuropathies 25. Effects of subthalamic nucleus stimulation on cardio- & cerebro-vascular modulation in Parkinson disiease 26. rhNGF in Diabetic Neuropathy 27. Neurophysiologic and autonomic evaluation Fabry patients. 28. Evaluation of peripheral sudomotor and vaso-motor dysfunction in Familial Dysautonomia 29. Cerebral autoregulation during progressive physical challenge 30. Influence of Sildenafil on cerebral perfusion, auto-regulation & baroreflex sensitivity 31. Pregabalin Open Label, Extension Trial in Patients with Painful Diabetic Neuropathy 32. Interaction between autonomic dysfunction and frontobasal cortical lesions in epilepsy pats. 33. Influence of Sildenafil on cerebral perfusion and autoregulation and baroreflex sensitivity 34. Development of autonomic testing equipment in erectile dysfunction 35. Cardiovascular and erectile autonomic dysfunction 36. Development of autonomic testing equiment 37. Evaluation of sympathetic and parasympathetic modulation of cardiovascular parameters and of pupillary hippus by means of spectral analysis 38. Pregabalin in Painful Neuropathies Study Protocol 1008-155 39. Relation between neuro-physiologic and autonomic function and recombinant human betagalactosidase (Fabrazyme) infusion interval in Fabry patients 40. Influence of Sildenafil on cerebral perfusion and autoregulation and baroreflex sensitivity 41. Evaluation of cardiovascular and respiratory control during sleep and arousal in Familial Dysautonomia patients 42. Relation between neurophysiologic function & dosage interval of alpha-galactosidase A infusion in Fabry patients 43. Benefits of agalsidase beta therapy on baroreflex sensitivity in Fabry patients 44. Diabetes, Cognition, and the Brain 45. [Brain dysfunction in Obesity and T2DM, impaired cerebro-vascular reactivity due to insulin resistance - a cause of cognitive impairment in T2DM. 46. Central autonomic dysfunction after traumatic brain injury 47. Central autonomic dysfunction after trau-matic brain injury – a possible cause of increased mortality 48. Erectile Dysfunction and autonomic nervous system 49. improved clinical assessment of Pompe and Fabry patients 50. Sympathetic skin response in Fabry patients 51. Rare disease awareness activities 52. How to enhance expertise & treatment options for Fabry and Pompe patients 53. Correlation between autonomic dysfunction and NIHSS scores as predictor of cardiac risk after stroke 54. Sexual Dysfunction (SDF) in patients with Multiple Sclerosis (MS) 55. assessment of auto-nomic complications and resulting vital risk in elderly stroke patients by simple clinical tests 56. retrospective analysis of treatment data and disease progression in Pompe patients 57. Assessing benefits of agalsidase bela therapy on cerebral blood flow velocity and cerebrovascular resistance 58. Sexual dysfunction on post-stroke patients 59. Prospective observation of autonomic function - correlation between autonomic dysfunction & disease progression & severty in patients with relapsing remittent MS CLINICAL TRAILS PARTICIPATION 1. A PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY OF THE EFFICACY AND SAFETY OF RECOMBINANT HUMAN NERVE GROWTH 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 20 / 22 Curriculum vitae Max Hilz FACTOR (rhNGF) IN SUBJECTS WITH DIABETIC PERIPHERAL POLYNEUROPATHY 2. A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study of the Safety and Efficacy of Recombinant Human beta-Galactosidase A (r-h beta-GAL) Replacement in Patients with Fabry Disease 3. Evaluation of Autonomic and Small Fiber Function in Patients with Fabry Disease Before and After Enzyme Replacement Therapy 4. Evaluation of Autonomic and Small Fiber Function in Patients with Fabry Disease During Enzyme Replacement Therapy 5. Evaluation of Variation in Autonomic and Small Fiber Function in Normal Subjects Using Repeat Measurements 6. Sexual Dysfunction (SDF) in patients with Multiple Sclerosis (MS) 7. Correlation between autonomic dysfunction and NIHSS scores as predictor of cardiac risk after stroke 8. Retrospective analysis of routinely assessed stapedius reflex response shows improvement of small muscle function in Pompe patients receiving enzyme replacement therapy 9. Prospective observation assessing relevance of autonomic nervous system testing and correlation between autonomic dysfunction and disease progression and severity in patients with relapsing remittent Multiple Sclerosis Memberships 1994 Founding Member, German Autonomic Society since 1996 Secretary, Autonomic Nervous System Research Society, University of Erlg.-Nbg. since 1997 Member, Section of the Autonomic Nervous System, American Academy of Neurology since 1997 Member, Section “Diabetes and Nervous System“ of the German Diabetes Society since 1997 Board of Directors, German Society of Neuromuscular Diseases since 1999 Board, German Research Society on Erectile Dysfunction “Sexuality & Health“ since 1999 Board, “Diabetes and Nervous System“ Section, German Diabetes Society 1999 - 2002 Secretary, “Autonomic Nervous System” Section, German Neurological Society (DGN) 2002 - 2011 President, German Autonomic Society 2004 - 2008 Board of Directors, American Autonomic Society 2004-2008 President, European Federation of Autonomic Societies (EFAS) 2007 - 2010 Chair, Autonomic Section, American Academy of Neurology since 2007 Member, Guidelines Committee, German Diabetes Society 2008 - 2014 Chair, Autonomic Nervous System Scientist Panel, European Federation of Neurological Societies since 2014 Chair, Autonomic Nervous System Subspecialty Scientific Panel European Academy of Neurology, EAN 1996 Cooperation in development of autonomic testing reimbursement (CPT) codes (American Medical Association) since 2002 Guidelines committee, German Neurological Society (DGN): guidelines on syncope; guidelines on erectile dysfunction since 2003 Guidelines committee, German Diabetes Society (DDG): guidelines on neurological diabetic complications since 2006 Guidelines committee, European Federation of Neurological Societies: EFNS guidelines on orthostatic hypotension 2008-2010 Development of autonomic nervous system subspecialty board examination (United Council of Neurological Subspecialties, USA) 2011 Consensus committee, American Academy of Neurology & American Autonomic Society: consensus development on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 21 / 22 Curriculum vitae Max Hilz OTHER PROFESSIONAL ROLES 1988-1992 Member, Commitee for Hospital Hygiene University of Erlangen-Nuremberg since 06/1990 Member, Drug Advisory Board, University Erlangen-Nuremberg 1996 Secretary, Autonomic Research Society, University Erlangen-Nuremberg 1996 Cooperation in development of autonomic testing CPT codes (American Medical Association) since 05/2003 appointed as Neurology Board Examiner by Bavarian State Medical Board since 1996 appointed as examiner in Clinical Neurophysiology, (German Clinical Neurophysiology society) since1999 Editorial Board, “Clinical Autonomic Research” since 2012 Clinical Associate Editor, Autonomic Neuroscience, Basic and Clinical HONORS / AWARDS 10/15/ 73 – 12/31/80 Scholarship of the Bavarian Government for Highly Talented Students 01/28/93 Poster Award, German Society for Critical Care Neurology, Wuppertal, Germany 01/30/2009 Honorary Professor, University of Transylvania, Brasov, Romania 06/11/2012 Honorary Professor, Zhengzhou University, Zhengzhou, P.R. China 01/30/2015 15th Valsalva lecturer, Honorary Member of Italian Autonomic Society Other Relevant Information I have trained numerous residents and fellows in general neurology, acute and intensive care neurology, clinical neurophysiology, and central and peripheral autonomic nervous system diseases at the University of Erlangen-Nuremberg, at New York University and at many international teaching conferences. I have organized at least 25 national and international scientific and teaching conferences to broaden and deepen the knowledge about the many diseases of the autonomic nervous system. I believe that my clinical, teaching and scientific activities have added to a wider and better understanding of the relevance of autonomic nervous system disorders in neurology and medicine in general. One of my specific research interests deals with the clinical investigation of the central autonomic nervous system, its hemispheric and topographic representation, and the long-term cardiovascular effects of isolated or diffuse brain lesions, e.g. in patents with epilepsy, multiple sclerosis, stroke or traumatic brain injury. We were able to contribute to a better understanding of the implications of brain lesions on bodily function, particularly on the modulation of the cardiovascular system. 15/10/15 © European Union, 2002-2015 | http://europass.cedefop.europa.eu Page 22 / 22