13th Annual Meeting of the ECNM
Transcription
13th Annual Meeting of the ECNM
Welcome to Munich str. rk s tr . hauer rp a do Hirsc tr. eo Iffl an ds Th O et rc tin he ge nf ns el tr. ds tr. . Str r. -St Th ere sia Mö hls ria Ma Isar str. str. Möhlstr. str. W id Reitmoren m ay er st r. eg er tr. eg lle r. tr. aße tr. ss zs et M Lo th rin ge Rabls Simon-Kroll- tr. riser Str. Pa St r. Weißenburger Weißenburgerstr. Platz kan nzis Fra rgers liu rst rS tr ris er tr. yers Co r ne Ke St ein r. . . str St Rosenheimer Platz leib Sch tr. Ste ing Hoc hst ers t r. r. er r. tr. tr. m ers t ns str . en Milch r. ins er-W üll tr. Zells rl-M Ka tr. ei ns tr. str. rst . tr hs M lle ma Gall Preysingstr. ilc Ke enbe Str Eggernstr. tr Zell . Wiener Platz PreysingPreysingstr. platz nh Ism str rS ne Wie Einsteinstr. Max-WeberPlatz Pa ere Inn Ro Freud anin ger Str. Maria -There sia- ax zn lst Rabls ell Herr gott tr. ns r. tr. il-R ied el- erstr. Le tr. rns Ste str. el ins üt tr. seck tr. el pp Str. Gr Pra ter Praterinsel eli zs Qu hi . Lilie ia tr mt st ar rs am S m M ch ge Ze - r. ei id in s Str. nckPla rücke nstr. A B SCIENCE Maximiliananlagen se Lilie ar CorneliusBrücke hw egente . pp Ze h Sc orAm Gries ninge Oett str. Ta . cke l hw d ar Ba Reitm . rastr and Alex tr. hs ac tte nb Str str. sd r ei n Isa St t- Er Em Oett tr. fe r. Adelgun Ka brü um Zenneckbrücke Sc We would like to thank our sponsors Prinzr str iliansb r. igs se sin Stern ch- l- Maxim Thiers chstr. denstr. nstr. or r. . Europaplatz str. f- st hlstr Legal Disclaimer Neither the organizer nor EUROKONGRESS GmbH shall be liable for accidents, bodily injury, theft as well as for additional costs due to the change of event date, location, program or similar. Liability for additional costs due to delays, changes or cancellations of flights, trains or other means of transport as well as due to strike action, illness, weather or environmental disasters is also excluded. It is the responsibility of each participant to arrange appropriate theft-, accident-, health as well as travel cancellation insurance. Participants as well as accompanying persons take part at their own responsibility and risk. Luitpoldbrücke Liebig- üh ist as s or M r. . ers tr. ad r. st Seitz- rs tr. bh er Lie . str rBa ad e nd Höc Siebertstr. Crusiusst lstr. er ud Br str. str. Piloty Ma Falkenberg rst str Str. alls . Lu tr. La eg in Wurz nd s erstr . Sto str. llb H e erg Th Rudrzogom olf-S as-Wi tr. mmer -Ring Knöbe l- Neuturmstr. Str . nd o Or la r. st en ze Kl Lä dw tr. -Ko m be Lu st st bach- r. st ze Th tr ReichenbachBrücke lds Kön ß-Rin trau F.J.S tz Mars tallpla en gra b tr. ns ark str. ss str. igins tr. Kaulb achst r. U3 · U6 Lud wig str. zstr. as se ner gs tr. Die Bu r Sp Hl .Ga Gei ss ste Ni es la Str. er t-Z is tlSt r. Pr ä aß g te Fürs Str. fner-Döp Karl atin The str. Wein s tr. ns se Ro Residen erstr . . Str erab Fa ulh rd.tr. str. zari Thie Ma rec ks fra Liebuen str. st r Kl en iu n inge alie Am nstr . lenzes tr. r. tr. Jahnst lzs Ho el Gewürz- Mariannenstr. Mariannenplatz e Boschus brücke M Ba Hans-S achs-Str. Ja hn st r. r. Ho e er rer A ng Unte Ang ert str. or- r. st Pestalozzi- Schwabinger Bach nstr . tr. ken s Tür Os ka r- str. Ka me str liter. r. Ho tt Herz r. ist zz olz str. r. st iersch hls str. Widenmay tr. ers ken Tür Eise nman nstr ers t ogzog Her H ma artn str n. Ka Ettstr . Kap lens eltr. . elmWillh tr. ers chn . uen lo Fra lzs t Schillerstr. . bstr Goethestr. Mais tr . tr. Häberlstr. Kaulb achst r. Kön igins tr. r. hst olp rau d Bar str Barerst r. . to Ot Herz Max og-Str. Str. Str. Willhelm- Liu tp str old. Zweigstr. Schillerstr. Goethestr. Heinrich-Str. r. ts t er Herzog- lkir Paul-Heyse-Str. Str. Paul- hu b Sc r. . tr. r. st r. Baaderplatz Ko str r. st en her st . an ts at at elc en d Se rn Isartorplatz st lin Rosenbuschstr. str. bse Prof. Dr. med. Karl Sotlar [email protected] Prof. Dr. med. Hans-Peter Horny [email protected] Max-JosephBrücke str. Co Kan Isartor tr. Stein rm ert imilia str. tte tin Fraunhoferstr. tr. ers ad st a Ba r de . str en Rob herr en Kl Av 5 Lieb Bu str. ·U Mannhardtstr. . alstr . tr ns Reichenbachplatz 4 Max . tr Rum - U . Hildegardstr. str. - ford er - Bürkleinstr s al Sc h st ne r. id Liebig Lehel n Ka s ze st ke üc ibr tr. . tr us rst e Zw r. st ha r. ken H r. er üc rn M br ar ch St ie r. Ho ns tr . Tal re dls PROGRAM Contact persons lis str Paradies- . str. ße z- Ick Pl u- de Pl Frauenstra r. Ba v a ri ar ing Bar tr. ers tr. ers Kat enLuis . Goethestr. Mittererstr. Senefelderstr. Zollstr. str. Brä Le zl at Am r. Westenriederstr. st tts r. lin r ge tr. rst Tal 2 Ut st m r. st l eu . r. hlstr ss ne zie pu Ka Südlicher Friedhof hofs lke n str turm . - ste Gärtnerplatz st lo rmü nta r lle er ste r m ur Ko sta We lten ilian- Fa Viktualienmarkt ü M Maxim Pfi - Ick Holzplatz tr. elius- of str. ers tr. se nh Stephan üll str.A au tr. M haft rkt Fr . Corn en dsc ma er d Rin Ro la ek . Th str str. sen erstr gers Se ba Pla stia tz n au ptf eu erw . - Bl ms r. . . r ge an H Zie st dn e aß isstr Ob mm str. er- Ho f- Marienplatz ss la . Ein str Hy gse hers um r ge n era r ge Sendlingertor sburg . Str of. . A.d r ge in ss str. Le Aug ttSa rstr. le mh in dl . . tr rS de el en ab gr Asa enstr Raisin - g Rin Goetheplatz Hac k ens enstr. tr. unn n e a fst Ho erstr f en . Br er alstr tt 3 Rie aus Him nstr Unsöldstr. Sigmundstr. rtenst phr. Christo str. Perusastr. Lan ente Hofga Schra t rs spit Se Flieg ß ra st m ur dw Rothn mundLi str. 6 mer ße . rstr. rs fing Eck stra See n- he zreg str. h c Ler Prin vo ro na s Ei V.-d.Tann -Str. V.-d .-Ta nn-T unn el Foto: Spatenhaus arten Dia c ba riestr. Hofg eistr r. Schäffle te ne stie gu Althei Maff rub Kau r. St gl- ler r. st Sinpie id s hm Sc in tr. ße ar -S lstr. ng Au r- straße st n Li gspita me n platzaden- we . Obe straße ·U Walt dw 2 Lö erstr Herzo stra ri Mozart- ·U tr. haus str. . Pro Maxburgs Neu e m- U3 Pace straß Nußbau tr. 1 ner . Hofgarten Str. rnturm Jungfe Salv ator- Maximiliansplatz . str us ch Pr an Ro eldstr Gale Odeosplatz enstr . W ba ittelsBrien cherpla tz ners tr. Fü H.-Lingg- Adolf-Kolping-Str. U O Schönf Ti Ca Englischer Garten str. Bayerstr. r. ildenst va 1 ens hov Kaiser Ludwig Platz Beet- id Karlsplatz (Stachus) Schlosserstr. Marth Ba ofer- . Theresienwiese m tr. str. Pettenk ch yrs tzen . . . l- lma Schü Jägers Fink tr ttos erstr iller-Ring .-M tr. rstr llistr Joseph- str nd Brie F ärb Landwehr- la Uh le Prie . Landwehrstr. str. S -S str Schwanthalerstr. t.- H. en v tr. berg ag rn ha ng Sc Ri K. Bahnhof Platz Schwanthalerstr. St.-PaulsPlatz Elis Rhein nna- . Sonnen- 5 ·U s str. St.-A Alter Botanischer Garten . U4 . Sophien- me lS e id rstr fens lstr str Bayerstr. ig.S nne Kar Läm tr. ststr Hop . Hauptbahnhof ie KarolinenFoto: Derplatz Pschorr har De . lfstr St r. n-B lstr . str dw ora U2 tr. . z-Lu tz tr. nstr Arnu . spla hs Hirte . Prin ep . r. n- str -Str . Aug nig Bar Kö ger Jos lfstr Hackerbrücke sen ber r. Königsplatz ust ens tr. . str str . uer- Dacha Arnu Eli Arc isst els aße r. gst resie Gab närst Universität ellin The r Str Kar Sch Reichen- tr. Brie Veteri tr. nns nne nis Ste inic . Sch kew Aug u ste nst r. Stiglmaierplatz Foto: wikimedia.org, Horemu tr. str aße . rss str. tr. r. ma lstr Ma ger ien ina Kar ber res Tha . Rott er Str San dst r. gstr els The -vo burg Gab eils str. er S t eim ers tr. bur phen Pa pp en h ten U7 Nym Herb Blu tr. inh R. W U1 · ns Ste Heß agn pru str. Lin raße uer-St Dacha str. Schle ißhei mer St Erz str. San dst r. gie sen r. ße reis str. eg run wald Arc isst . tr. Linp hor Luis ens tr. lstr 3 Spatenhaus an der Oper Residenzstraße 12 Geschwister80333 Munich Scholl-Platz Zieb 2 land str. Blü ten Der Pschorr am Viktualienmarkt str. Viktualienmarkt 15 80331 Munich 1 Heß str. Anatomische Anstalt der Ludwig-Maximilians-Universität Kre Pettenkoferstraße 11 ittm Theresienstr. a str 80336yrMunich . Institute of Pathology – Ludwig-Maximilians-Universität München Thalkirchner Str. 36 80337 Munich, Germany M Gaig Organizer . 13th Annual Meeting of the ECNM Munich, October 8 -10, 2015 Program Thursday, October 8 13:30 Welcome Coffee 14:00 Karl Sotlar & Hans-Peter Horny (Munich, Germany) Welcome 14:10 Thomas Kirchner (Munich, Germany) Welcome Notes 14:25 Emir Hadzijusufovic (Vienna, Austria) ECNM Homepage 14:30 Michel Arock (Paris, France) & Peter Valent (Vienna, Austria) Status of the ECNM in 2015 Session II: Mast Cell Activation and Allergy in Mastocytosis Chairs: B. Nedoszytko & L.B. Schwartz 17:15 Sigurd Broesby Olson (Odense, Denmark) Diagnostic Algorithm for Patients with Suspected Mastocytosis 17:30 Patrizia Bonadonna (Verona, Italy) Hymenoptera Venom Allergy in Clonal Mast Cell Disorders 17:45 Hanneke Oude-Elberink (Groningen, Netherlands) Treatment of IgE-Dependent Allergy in Mastocytosis 18:00 Cem Akin (Boston, USA) Mast Cell Activation Syndrome: Update 2015 18:15 Boguslaw Nedoszytko (Gdansk, Poland) Genetic Patterns Predisposing to Anaphylaxis in Mastocytosis 20:00 Faculty Dinner 14:40 Peter Valent (Vienna, Austria) & Michel Arock (Paris, France) Presentation of the Researcher of the Year 2015 14:45 Lawrence B. Schwartz (Richmond, VA, USA) Development of Tryptase as Biomarker in Mastocytosis 15:15 Coffee Break Session I: Skin and Childhood Mastocytosis Chairs: K. Brockow & C. Akin 15:45 Karin Hartmann (Cologne, Germany) Heterogeneous cutaneous lesions in childhood-onset mastocytosis 16:00 Luis Escribano (Madrid, Spain) Lesional Patterns of CM in Children and Clinical Implications 16:15 Knut Brockow (Munich, Germany) Treatment of Cutanous Mastocytosis in Children and Adults 16:30 Franziska Ruëff (Munich, Germany) Management of Anaphylaxis in Mastocytosis 16:45 Coffee Break Program Friday, October 9 8:10 Welcome Coffee Session III: Presentation of ECNM Registry Projects Chairs: P. Valent & W.R. Sperr 8:30 Wolfgang R. Sperr (Vienna, Austria) Introduction and Presentation of Pilot Project: IPSS for mastocytosis 8:40 Anja Rabenhorst & Karin Hartmann (Lübeck, Germany) Age-Adjusted Diagnosis and Prognostication in Mastocytosis 8:50 Massimo Triggiani (Salerno, Italy) Spectrum of Mediator-Related Symptoms in Mastocytosis 9:00 Hanneke Kluin-Nelemans (Groningen, Netherlands) Clinical significance of blood count abnormalities in mastocytosis 9:10 Marek Niedoszytko & Boguslaw Nedoszytko (Gdansk, Poland) Impact of allergic disorders and anaphylaxis in mastocytosis 9:20 Andreas Reiter & Juliana Schwaab (Mannheim, Germany) Impact of serum chemistry on diagnosis and treatment of systemic mastocytosis 9:30 Serena Merante (Pavia, Italy) Treatment of patients with mastocytosis: comparison of response rates 9:40 David Fuchs & Rosemarie Greul (Linz, Austria) Risk of SM in patients with MIS 9:50 Roberta Zanotti & Patrizia Bonadonna (Verona, Italy) Impact of bone marrow mastocytosis (BMM) 10:00 Nadja Jäkel (Leipzig, Germany) Clinical impact of serum tryptase levels in the FU in SM 10:10 Elisabeth Aberer (Graz, Austria) Skin lesion in different categories of mastocytosis 10:20 General open discussion of individual projects Session V: Hot Topics in Mastocytosis Chairs: J. Gotlib & K. Brockow 14:00 Joanna Renke & Magdalena Lange (Gdansk, Poland) Antibody deficiencies in children with mastocytosis – a new face of the disease? 14:15 Jaap J. Doormaal (Groningen, Netherlands) Diagnosis and Management of Osteopathy in Mastocytosis 14:30 Michel Arock (Paris, France) KIT Mutation Analysis: Proposed Standards and Algorithm of the ECNM 14:45 Olivier Hermine (Paris, France) Mental and Psychiatric Problems in Mastocytosis: Diagnosis and Management 15:00 Almundena Matito (Salamanca, Spain) Familial Mastocytosis and Management of Mastocytosis in Pregnancy 15:15 Melody Carter (Bethesda, MD, USA) tba 15:30 Coffee Break Session IV: Pathology Chairs: H. Kreipe & H.-P. Horny 11:30 Dan Arber (Stanford, USA) Myeloid neoplasms: News from the WHO classification system 12:00 Hans Kreipe (Hannover, Germany) Eosinophils and Mast Cells in the Neoplastic Bone Marrow 12:15 Sigrid Regauer (Graz, Austria) Mast cells in pain disorders (vulvodynia, chronic bladder pain) and in lichen planus 12:30 Hans-Peter Horny (Munich, Germany) Unusual Cases: Mimickers and Chameleons in SM Session VI: Basic Science and Cell Research Chairs: A. Reiter & M. Triggiani 16:00 Animesh Pardanani (Rochester, MN, USA) Mastocytosis research update from Mayo Clinic 16:15 Harald Bartsch (Munich, Germany) MicroRNA expression profiles in mastocytosis 16:30 Thomas K. Kristensen (Odense, Denmark) Targeted ultra-deep next generation sequencing as a method for KIT mutation analysis in mastocytosis 16:45 Andreas Reiter (Mannheim, Germany) Mutational Profiles of CFU-GM in various Categories of SM 17:00 Gunnar Nilsson (Stockholm, Sweden) Mast cells and mediators in mastocytosis 17:15 Michael Huber (Aachen, Germany) Positive and Negative Control of IgE-dependent MC Activation 17:30 Ivan Alvarez-Twose (Toledo, Spain) Diagnosis and classification of well-differentiated systemic mastocytosis 17:45 Olivier Hermine (Paris, France) Masitinib for the treatment of severe systemic mastocytosis: Pooled phase 2 study simulation of phase 3 population and response criteria 18:00 Stéphane Barete (Paris, France) Treatment with Cladribine (2-CdA) in adult patients with mastocytosis 12:45 Lunch Break 20:00 Dinner (Der Pschorr, Viktualienmarkt) 10:30 Coffee Break 10:30- Registry Steering Committee Meeting (closed) 10:50 Discussion and Nomination of ECNM Registry Projects (closed) Program Saturday, October 10 8:15 Welcome Coffee Session VII: Proposed Clinical Studies: New Trials and Updates Chairs: L. Escribano & K. Hartmann 8:30 Frank Siebenhaar (Berlin, Germany) Clinical Trials to Control Mediator-Related Symptoms 8:45 Bernd Jilma (Vienna, Austria) Proposed DAO Trial in Patients with SMSY 9:00 Serena Merante (Pavia, Italy) JAK2-Inhibitors in Mastocytosis 9:15 Bjorn van Anrooij (Groningen, Netherlands) Clinical Trials with PKC412 in ISM 9:30 Jason Gotlib (Stanford, CA, USA) Update of PKC412 Trials in Advanced SM and MCL 9:45 Sigurd Broesby Olson (Odense, Denmark) Targeted Approaches to control IgE-dependent Reactions in Mastocytosis Session IX: Late Breaking Abstracts Chairs: M. Arock & K. Sotlar 12:30 Vito Sabato (Antwerpen, Belgium) Update of Familial Hypertryptasemia 12:45 Selim Yavuz (Istanbul, Turkey) Chronic Mast Cell Leukemia 13:00 Martin Zenke (Aachen, Germany) Induced Pluripotent Stem Cells (iPSC) for Disease Modeling in SM 13:15 Deepti Radia (London, U.K.) Management of Patients with Mastocytosis in the U.K. 13:30 Judit Varkonyi (Budapest, Hungary) Neoplastic and non-neoplastic comorbidities in systemic mastocytosis 13:45 Francesca Levi-Schaffer (Jerusalem, Israel) Mast Cell-Eosinophil Interactions in Health and Disease 14:00 Mariana Castells (Boston, MA, USA) Drug Reactions in Mastocytosis: Is Pretesting useful? 10:00 Coffee Break 14:15 Closing Remarks and Announcements Session VIII: Proposed Basic Science and Translational Projects Chairs: G. Nilsson & K. Sotlar 10:30 Olivier Hermine (Paris, France) ECNM Application Proposal: Horizon 2020 10:45 Carlo Pucillo (Udine, Italy) MANTRA: Presentation of Concept 11:00 Celalettin Ustun (Minneapolis, MN, USA) Occult Mastocytosis and KIT D816V in CBF AML 11:15 Frank Siebenhaar (Berlin, Germany) EMBRN and other Basic Science Networks in the EU 11:30 Peter Valent (Vienna, Austria) Presentation of a Basic Science Network-Section of the ECNM 11:45 General Discussion 12:00 Coffee Break 14:30 End of Meeting