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(ERMIN r--~'-_o-,--- DUNIA KEDOKTERAN ISSN: 0125-913 X 1171/ vol. 36 no. 5/ Agustus 2009 A:""'_~""~-" __ ""~"'- __ ':'" .~ .• "'~~~ ....-u_ __ __~ __ http.//www.kalbe.co.id/cdk ~,"'-'4- ,_. __ • i • HASIL PENELITIAN Efektivitas Larutan Antiseptik Klorheksidin Glukonat 0,5% yang Tergenanguntuk Cuci Tangan" TIN.!AUAN PUSTAKA Toxic Shock Syndrome Prospect of Nucleic-Acid Based Immune System - RNAi as Potent Antiviral Agerits PROFIL Prof. Dr. Djoko Widodo, DTM&H, SpPD-KPTI Pasien adalah Sumber IImu yang Tidak Terbatas 1 . ~~;,.<:-- . f'~:.:; ;l, >.C~A: . ~ _ INFORMATIKA KEDOKTERAN '. :ir , ( Sistem Informasi Kesehatan dari tv'1asake Masa Johan Harlan Pus at Studi informatika Universitas Gunadarma Kedoktcran Jakarta. Indonesia Sistem Informasi dan Teknologi Informasi Sistem informasi adalah suatu tatar.an informasi (data), proses, manusia, dan teknologi informasi yang saling berinteraksi untuk mengurnpulkan, mengolah, menyimpan, dan menyediakan keluaran informasi yang dibutuhkan untuk menunjang organisasi. Teknulogi informasi adalah kombinasi antara teknologi komputer (perangkat keras dan lunak) dengan data dan teknologi telekomunikasi (jejaring data, citra, dan suara). Teknologi informasi merupakan salah satu komponen sistem informasi, walaupun di masa kini istilah sistem informasi seringkali dianggap sarna dengan teknologi informasi (Wager et al, 2005). kecil daripada komputer mainframe, namun berkemampuar. lebih tinggi. Perkernbangan teknologi informasi sejak 1980-an mentransformasikan proses komputasi yang sebelumnya semata-rnata bersifat otomatisasi ini menjadi sistem penunjang bagi dokter, perawat, serta pemasok layanan kesehatan lainnya. Ketersediaan akses terhadap Internet dan jejaring komputasi di masa kini dan akan datang diharapkan akan dapat memperluas ranah sistem informasi kesehatan dalam komunitas dengan fokus untuk memberdayakan pasien (Gambar 1; de Velde & Degoulet, 2003). Kompleksitas Perkembangan Sistem Informasi Kesehatan Fenggunaan komputer dalam bidang layanan kesehatan bermula sejak awal 1960-an, dalam bentuk sistem informasi rumah sakit (Hospital Information System; HIS), yang mencakup fungsi administratif maupun medis. Sistem ini terutama diranc~ng atas dasar orientasi keuangan untuk memfasilitasi manajemen penagihan biaya serta keluar-masuknya dan perjanjian bagi pasien dengan menggunakan perangkat teknologi informasi yang tersedia pada waktu itu yaitu komputer mainframe. Dalam perkembangan selanjutnya, tersedia pula layanan tambahan secara departemental (yang berdiri sendiri-sendiri) untuk laboratorium, apotek, dan radiologi. Pada saat itu telah tersedia komputer berskaia-menengah yang berukuran lebih 1960 r 1980 1990 2000 2010 Gambar 1. Arah perubahan teknologi informasi dalam sektor kesehatan (de Velde & Degoulet, 2003) ",CDK 386 1970 I AGUSTUS 2009 2020 -~;~.~"~ 7 ... Ii I!J ~ .. INFORMATIKA KEDOKTERAN 001 '. \ Gambar 2. Evolusi sistem informasi rumah sakit (de Velde & Degoulet, 2003) HIS : Hospital Information System CHIN: Community Health Information Network Proses otomatisasi medis yang bersifat departemental (berdiri sendiri-sendiri) mernbentuk sistem departemental tututup. Sistem ini relatif tidak efisien derigan seringnya terjadi pengulangan pengumpulan data yang sarna untuk gudang penyimpanan data yang berbeda (redundant storag~). Untuk meng ••fisienkan pernanfaatan data, dikembangkan sistem informasi rumah sakit tersentralisasi (HIS tersentralisasi) dengan satu basis-data tunggal untuk menyimpan seluruh data rumah sakit, narnun perluasan dan penarnbahan berbagai fasilitas dalarn suatu rumah sakit menyebabkan basis-data tunggal menjadi sangat besar dan kompleks. Basis-data tunggal yang sangat besar dan kompleks akan memperlambat proses komputasi, selain iru tiap pernbaharuan yang relatifkecil akan mernbutuhkan restrukturisasi besarbesaran pada basis-data. Alternatif yang iebih menguntungkan ialah dengan mengembangkan sistem departemental federasi sebagai perbaikan terhadap sistem departemental tertutup. Dalam sistem departemental federasi, data tetap tersebar di sejumlah basis-data yang berorientasi ranah masing-masing seperti laboratorium, apotek, radiologi, dan sebagainya, tetapi saling terinterkoneksi secara logik (relational databases) dan aksesibel secara kcmbinasi untuk prose~ komputasi dan berbagai aplikasi pada satu komputer sentral. Dalam tahap lebih lanjut, ketersediaan workstation multimedia te1ah me mungkinkan dikembangkannya sistem informasi I umah sakit terdistribusi (HIS terdistribusi). Dalain sistem informasi rumah sakit terdistribusi, basis-data tetap tersebar di berbagai bagian rumah sakit dan saling terinterkoneksi dalam suatu jejaring area-lokal (local area-network; LAN). Di masing-masing bagian rumah sakit ini tersedia komputer lckal (workstation) yang dapat melakukan proses komputasi dengan mengakses basis-datanya sendiri maupun basis-data bagian lain yat1.gierinterkoneksi dalarn jejaring (Ccltri, 2006). Perkembangan terbaru yang lebih menekankan pada pernberdayaan pasien dalam ranah komunitas telah menghasilkan pengembangan aplikasi sistem informasi rumah sakit terdistribusi dalam jejaring informasi kesehatan komunitas (Community Health Information Networks; CHIN). Di sini keseluruhan sistem informasi rumah sakit rnaupun sistern informasi berbagai sentra layanan kesehatan lainnya saling terinterkoneksi dalam satu jejaring informasi kesehatan komunitas. Jejaring dan Komunikasi Data Kesehatan Komunikasi data adalah transmisi data elektronik di dalam ataupun antar kornputer dan devais (d~"ice; peralatan) lain yang berkaitan. Untuk melakukan kornunikasi antar dua program atau dua devais yang berbeda harus dibangun suatu antariCDK muka (interface). Dalarn suatu jejaring komputer (computer network) seperti jejaring area-Iokal diperlukan adanya protokol, yaitu seperangkat aturan dan sinyal yang digunakan oleh komputer dalarn jejaring untuk saling berkomunikasi. Keberadaan protokol akan membatasi dan mengurangi, walaupun tidak dapat menghapuskan penggunaan antar-rnuka. Contoh protokol antara lain yaitu Transmission Control Protocol/Internet Protocol (TCP/IP) yang digunakan pada trasmisi data dari server pengunduh dalarn jejaring Internet ke komputer pengguna. Untuk mengembangkan JeJarmg informasi kesehatan komunitas, harus diupayakan pencapaian interoperabilitas antar komputer diberbagai institusi layanan kesehatan, yaitu kemampuan untuk melayani pertukaran data antar sistem informasi institusi. Pencapaian interoperabilitas dalarn kornunikasi dan transmisi data elektronik pada layanan kesehatan ini hanya dimungkinkan dengan adanya standar, yaitu protokol yang dapat diterima dan digunakan oleh sekurung-kurangnya sebagian besar dari institusi layanan kesehatan sedunia. Tiga standar pertukaran data yang terpenting yang ada pad a saat ini untuk transmisi data layanan kesehatan ialah HL7, DICOM, dan MIB. HL7 (Health Level 7) adalah standar untuk transmisi data teks, DICOM (Digital Imaging and Communications in Medicine) adalah standar untuk transmisi data citra (image), sedangkan I AGUSTUS 2009 387 r ~- ~4;;.Ji-- A·r4~-.c: ./~~ :!l~ ~lw. INFORMATIKA KEDOKTERAN ., MIB (Medical Information Bus) adalah standar untuk transmisi data dari devais sisi-ranjang (bedside devices) yang umumnya berupa grafik (Gambar 3). Ketiga standar ini dikembangkan dengan maksud untuk penggunaan global sedunia, sedangkan untuk implernentasinya masih dibutuhkan pengcmbangan versi lokal di masing-masing negara yang berminat. - . Komunikasi klinik dan administratif Komunikasi devais sisi-ranjang Pengambangan dan Aplikasi Sistem Inforrr.asi Kesehatan di Masa Depan Pembahasan mengenai standar di atas hanya merupakan sebagian di antara sejumlah besar permasalahan yang harus diatasi dalam pengembangan Sistem Informasi Kesehatan. Kemajuan teknologi tidak dapat langsung diterapkan, dibutuhkan waktu beberapa tahun sebelum pemikiran manusia dapat melihat manfaatnya dan bersedia untuk menerirnanya. Beberapa tahun berikutnya dibutuhkan untuk mengimplementasHcannya dalam suatu sistem informasi, dan setelah irnplementasinya ternyata menimbulkan permasalahan lain, baru biasanya akan ada upaya untuk menyusun regulasi administratifnya (Gambar 4). Komunikasi Citra Gambar 3. Standar pertukaran data pada sistem informasi rumah sakit (de Velde & Degculet, 2003) T;mnutakhirkan, teradaptasi Regulasi Administratif 1 i 3 5 4 6 8 9 10 11 12 13 14 15 Kerangka Waktu (Tahun) Kadaluwarsa, tak teradaptasi Gambar 4. Dampak perubahan teknologi terhadap pemikiran manusia, organisasi, dan regulasi administratif (de Velde & Degoulet, 2003) Kepustakaan 18 1. Coltri A, 2006, Databases in Health Care, dalam Aspects of Electronic Health Record Systems, 2nd edn, eds Lehmann HP et ai, Springer, New York, pp 225-25l. 2. de Velde RV, Degoulet P,2003, Clinical Information 3. Wa'ger KA, Lee FW, Glaser JP,2005, Managing System: A Component·Based Health Care Information $CDK Approach, Springer, New York. Systems: A Practical Approach for Health Care Executives,Jossey·Bass, San Francisco. I AGUSTUS 2009 (ERMIN DUNIA KEDOKTERAN http.//www.kalbe.co.id/cdk ISSN: 0125-913 X I 181 / vol. 37 no. 8 / November - Desember 2010 HASIL PENELITIAN TINJAUAN MMPI-2 Score among Indonesian High School Graduates Detected as Substance User PUSTAKA Aripiprazol sebagai Terapi Tambahan pada Gangguan Depresi Mayor --- -- .. --~----- ..- ----~ ._ PROFIL Dr. Tun Kurniasih Rastaman, Sp.KJ "Semua Dokter (hendaknya) Ingat Sumpah Hipocrates" .... - .-. --~-.- ..- ....-.... _. _._ .. _ ... -.- ...-.... _ ..- t.~ - (!J"'~';(!J 1!J~""ff~ HASIL PENELITIAN'...---~:-==----- _ MMPI-2 Score among Indonesian High School Graduates Detected as Substance User Johan Harlan Informatics Study Center, Gunadarma University Jakarta, I INTRODUCTION MMPI serves as the most widely used personality inventory, i.e. to generate descriptions of and inferences about respondents based on their test results.' Substance users are presumed to exhibit distinct personality aspects.s-' that could be detected by MMPI test. This study is intended to obtain personality aspects of substance users based on their MMPI test results, and to compare them with personality aspects of non-users. MATERIAL AND METHODS The tern, 'substance users' in this study includes narcotic users (morphine and its derivatives) as well as psychotropic and other illicit substance users (benzodiazepines and its derivatives; marijuana; amphetamine and its derivatives; and methamphetamine and its derivatives). The detection of users were based on urine test results, supported by questionnaire on history of narcotics and other illicit substance use, and psycho!ogical interviews. Based on urine test (table 1), the users are classified as THe users (marijuana; tetrahydrocannabinol), BZO users (benzodiazepines or its derivatives), AMP users (amphetamine or its derivatives). MET users (methamphetamine or its derivatives). and MOP users (morphine or its derivatives). 574 ~ CDK I NOVEMBER· Urine tests were performed on all candidates enrolled in Gunadarma University in 2006 as part of screening tests for new students. The screening tests were conducted in several sites in Jakarta and West Java, Indonesia. All candidates who were detected as users were included in the study sample. For each user, a non-user candidate of similar gender was selected as control. The control subject was the one with nearest registration number with his / her substance user counterpart. After obtaining informed consent from each respondents, they vsete asked to complete questionnaires on demographic data and history of narcotics and other illicit substance use, and underwent MMPI-2 tests The main scales of interest in this study are validity scales, clinical scales, and content scales (table 2). Sample size calculation was not done, as the study is exploratory in design; and the overall users to be detected are estimated to be small in number, hence all of them should be recruited as study sample. Data processing and statistical analyses were done with STATA 8. Mean differences of various MMPI scale scores between user and non-user groups were analyzed with Mann-Whitney test, as the sample size was presumed to be DESEMBER 2010 ~~ HASIL PENELITIAN small in number. Table 1. Types of urine tests in substance ~~ user study, '2006 RESULTS A total of 5560 candidates (3582 males and 1978 females) were examined during enrollment process; 21 (18 males and 3 females) were detected as substance users. Eighteen male candidates were detected as THe users and 3 females were detected as BZO users; 2 male- and 1 female users withdrew early in the enrollment process, leaving 16 male- and 2 female users in the study. No other type of illicit substance user was detected among the examinees. As control, 18 non-user candidates (16 males and 2 females) were recruited. Total sample size was 36. After obtaining detailed explanation on the study objectives, all 18 users and 18 non-users gave their informed consent and agreed to join the study. Table 2. The main scales of interest in substance user study, 2006 Basic characteristics of study population are shown in table 3. The two groups are fairly comparable. The sole obvious different characteristic is first-child position - 66.7% among users vs 38.9% among non-users. Average number of siblings is 3.17 in user's family vs 3.50 in non-user's family. Assessment of L, F, and K validity scale scores shows that all test results are invariably valid. Although maximum true-scores for the L, F, and K scales are 79, 82, and 78 consecutively," not a single invalid profile is found. The mean raw-scores of validity scales for the user and non-user groups are shown in table 4. Table 3. Basiccharacteristics of respondents in Indonesian substance user study, 2(X)6 The mean raw scores of clinical scales fer user and nonuser groups are showed in table 5. Statisticaiiy significant difference was detected for Scale 0 (Social Introversion) (p = 0.035), but the result of this exploratory study can not be generalized as that obtained from a confirmatory one. In Scale 2 (Depression) and Scale 3 (Hysteria), the p values are 0.099 and 0.090 consecutively, which might be statistically significant should the sample size is greater. The mean raw-scores of content scales are shown in table 6. The only content scale that is statistically significantly different between groups was Scale FRS (Fears). ( p= 0.005). DISCUSSION Substance users prevalence (positive urine test-result prevalence) of 2.07%, 3.31%, 2.00%, and 0.49% had been detected during the Gunadarrna University enrollment processes in 1994, 1997, 2000, and 2003 consecutive I!" but these results cannot be compared, as the types of urine tests are net similar. The urine tests in 1994 was only for THe and MOp, while in 2003 and 2006 the tests were for THe, BZO, AMp, MET. and MOp'6 Positive urine test-result prevalence decreased since 2001. In 2001, 2002, and 2004 the detected user prevalence were 0.94%, 0.75%, and 0.42% consecutively'", The decreased prevalence may be just the consequence of decreased 4CDK Table 4. MMPI-2 validity scale scores in Indonesian substance user study, 2006 *) Mann-Whitney test I NOVEMBER· OESEMBER 201 0 575 !!I"1~ .~ HASIL PENELITIAN Table 5. MMPI-2 clinical scale scores in Indonesian substance user study, 2006 versity (28.6% if the average number of child in the family is 3.50). and the proportion of respondents who are the first child is obviously higher in the user group. Statistical analyses showed that THC and BZO users are more socially introverted than control group (table 5). They might also tend to be more depressed and hysterical (table 5). Assessment of the FRS scale scores indicates *) Mann-Whituey greater likelihood for substance users to report multiple specific fears or phobias.' compared with non-user group. Substance users in this study do not include severe dependence (perhaps also moderate dependence). test Table 6. MMPI-2 content scale scores in Indonesian substance user study, 2006 Drug Dependence Hospital, Jakarta data showed that more than one third of its drug-dependent patients (47.8% in 2002) were senior high school graduates.4 As this study is still exploratory, we hope to test the hypotheses generated in this study in a specially designed confirmatory study with greater sample size. Acknowledgements.The author is particularly indebted to Drs. Zainuddin SK, MPsi and Prof. Dr. Suprapti S. Markam (clinical psychologists). for their kind review of the manu- . script. REFERENCES *) Mann-Whitney test Graham JR. MMPI-2: Assessing personality and psychopathology. Npw York: Oxford University Press; 1990. number of substance users who enroll the university. In DrugDependence Hospital, Jakarta, Indonesia, the reported number of narcotic patients increased four-fold during the period of 2000-2004.7 2. Anthony Jc. Epidemiology of drug dependence. In' Galanter M, Kleber HD, .editors. Textbook of Substance Abuse Treatment. 2nd ed. Washington, DC: American Psychiatric Press, Inc; 1999. p. 47-58. 3. Cloninger CR. Genetics of Substance Abuse. In: Galanter M, Kleber HD, editors. Textbook of Substance Abuse Treatment. 2nd ed. Washington, In our annual screening test for new students, the pattern of results remain the same, mostly consist of THC users'", It should be noted that most narcotic prisoners initially consumed marijuana before turning to other illicitsubstances," DC: American Psychiatric Press, Inc; 1999. p. 59-66. 4. Information scriptions and Data Center, Health Ministry, Republic of Indonesia. Deof narcotics and substance abusers in treatment institutions for narcotics and substance abusers, 2001-2003 [in Indonesian]. Jakarta: Health Ministry, Republic of Indonesia; 2004. Miv1PI-A (adolescent) is recommended for 17 years old respondents': but the respondents were already graduated from high-school and had social relations with older school mates. Hence, they were not considered suitable to undergo MM~I-A test which contains adolescence-specific items in the areas of identity formation, school and teachers, etc.t lt should also be noted that some formal institutions nowadays also use MMPI-2 test for 17 year-old respondents.'? We also need one sole standard test for the all respondents in our study. 5. Indonesian]. Jurnailimiah 6. 576 $COK scales for In- Penelitian Psikologi. 2005 Jun;l(10):1-10. Harlan J. Execution report of medical examination and narcotics / illicit substance using screening test for new students, Gunadarma University, 1994-2006 [in Indonesian). University; Final report. Jakarta: Gunadarma 2006. Sponsored by Gunadarma Health Foundation. 7. Padmo L. Community-based prevention of substance abusing [in Indone- sian; cited 2006 Oct 1). Available from: http://www.bnn.go.id. 8. Another interesting fact is greater proportion of 'first child in the family'among users (66.7%) compared with in non-user group (38.9%). This may indicates greater likelihood for the first child in the family to become substance user among sample subjects. Based on the average number of children in the non-user families, a slight and non-significant increase in probability was noted for the first child to enroll at the uni- Harlan J. Standard values of MMPI-2 validity and content donesian hospital employees and senior high school graduates, 2003 [in Martin. Executive summary of "Narcotics prisoner problem research in Indonesian jails, 2003" [in Indonesian; cited 2006 Oct 1). Available from: http://www.bnn.go.id. 9. Lanyon RI, Goodstein LD. Personality Assessment. 3rd ed. New York: John Wiley & Sons, Inc; 1997. 10. Benet WE. Psychological assessment: testing and practice resources [updated 2007 October 2; cited 2007 November www.nlm.nih.gov/bsd/uniform_requirements.html. I NOVEMBER· DESEMBER 2010 10). Available from: http://