Netherlands Institute for Health Sciences (NIHES)

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Netherlands Institute for Health Sciences (NIHES)
Research Annual Report 2012
Netherlands Institute for Health Sciences (NIHES)
Assessment, Treatment and Translational Research in Recontructive Surgery
Epidemiology of diseases
Basic epidemiologic research
Clinical epidemiology
Biostatistics
Effects of screening and clinical interventions on population health
Determinants of population health and primary prevention
Clinical research in general practice
Implementation of diagnostic and interventional imaging technology
Assessment of diagnostic and interventional imaging technology
Development of acquisition and processing techniques for diagnostic imaging
Structuring of medical knowledge
Structuring of medical data
Assessment, Aetiology and Course of Child and Adolescent Psychiatric Disorders
13734, B&T Ontwerp en advies (http://www.b-en-t.nl)
Research Annual Report 2012
Netherlands Institute for Health Sciences (NIHES)
Adaptation of (future) patients to disease and treatment in order to improve counselling and guidance
Management and organisation of health care delivery
Quality and efficiency in health care
Competition and regulation in health care
13734, B&T Ontwerp en advies (http://www.b-en-t.nl)
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EMC NIHES-01-50-01-A - Assessment, Treatment and Translational Research in
Recontructive Surgery
Programme (brief description)
General Objectives
The program `Assessment, Treatment and Translational Research in Reconstructive Surgery¿
relates to research questions derived from three main patient groups: upper extremity disorders,
craniofacial disorders and patients requiring reconstructions after oncological resection.
Furthermore wound healing plays an important role in reconstructive surgery.
Within these three patient groups, we share the same three research topics, which are often
interrelated.
1) Development and evaluation of innovative clinical interventions, either in randomized or
cohort studies.
2) Development and application of new assessment tools, such as new imaging techniques and
measurement tools to be used for both diagnosis and outcome assessment.
3) Development and evaluation of innovative experimental interventions with a close relation to
the clinic.
Most clinical and translational research is multidisciplinary, resulting in collaboration with a large
number of clinical and preclinical departments.
Key Figures
Department
oral and maxillofacial
surgery
pediatric psychiatry
plastic and
reconstructive
surgery
rehabilitation
Total
Sp1
Sp2
Sp3
Sp4
SpTot
0,2
0,2
0,1
0,1
4,55
7,5
12,05
0,4
1,45
1,85
8,95
14,2
5,25
0
0
T1
T2
T3
Ttot
IS
FS
OP
Ptot
4
0
0
4
39
4
1
48
Thesis
Elzen, M.E.P. van den (2012, september 14). Finding the balance in treatment for patients with rare
facial clefts. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. I.M.J. Mathijssen.
Jong, T. de (2012, december 07). Long Term results in syndromic craniosynostosis. EUR.
Prom./coprom.: Prof. Dr. I.M.J. Mathijssen & Prof. Dr. S.E.R. Hovius.
Ongkosuwito, E.M. (2012, november 20). Aspects of hemifacial microsomia. EUR. Prom./coprom.: Prof.
Dr. S.E.R. Hovius & A.M. Kuijpers-Jagtman.
Tong, M. (2012, oktober 31). The effects of OTR4120 a heparan sulfate mimetic on improving acute
and impaired wound healing in rats. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius.
Article/Letter to the editor
Ardon, M.S., Janssen, W.G.M., Hovius, S.E.R., Stam, H.J. & Selles, R.W. (2012). Low Impact of
Congenital Hand Differences on Health-Related Quality of Life. Archives of Physical Medicine and
Rehabilitation, 93(2), 351-357.
Ardon, M.S., Selles, R.W., Roebroeck, M.E., Hovius, S.E.R., Stam, H.J. & Janssen, W.G.M. (2012). Poor
Agreement on Health-Related Quality of Life Between Children With Congenital Hand Differences and
Their Parents. Archives of Physical Medicine and Rehabilitation, 93(4), 641-646.
Driessen, C., Mathijssen, I.M.J., Groot, MR De & Joosten, K.F.M. (2012). Does central sleep apnea occur
in children with syndromic craniosynostosis? Respiratory Physiology & Neurobiology, 181(3), 321-325.
Erasmus MC – Research Annual Report 2012
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Driessen, C., Veelen, M.L.C. van, Lequin, M.H., Joosten, K.F.M. & Mathijssen, I.M.J. (2012). Nocturnal
ultrasound measurements of optic nerve sheath diameter correlate with intracranial pressure in children
with craniosynostosis. Plastic and Reconstructive Surgery, 130, 448e-451e.
Duraku, L., Hossaini, S.M., Hoendervangers, S., Falke, L.L., Kambiz, S., Mudera, VC, Holstege, J.C.,
Walbeehm, E.T. & Ruigrok, T.J.H. (2012). Spatiotemporal dynamics of re-innervation and
hyperinnervation patterns by uninjured CGRP fibers in the rat foot sole epidermis after nerve injury.
Molecular Pain, 8.
Duraku, LS, Smits, E.S., Niehof, S.P., Hovius, S.E.R., Walbeehm, E.T. & Selles, R.W. (2012).
Thermoregulation in peripheral nerve injury-induced cold-intolerant rats. Journal of Plastic,
Reconstructive & Aesthetic Surgery, 65(6), 771-779.
Elzen, M.E.P. van den, Versnel, S.L., Hovius, S.E.R., Passchier, J., Duivenvoorden, H.J. & Mathijssen,
I.M.J. (2012). Adults with congenital or acquired facial disfigurement: Impact of appearance on social
functioning. Journal of Cranio-Maxillofacial Surgery, 40(8), 777-782.
Elzen, M.E.P. van den, Versnel, S.L., Duivenvoorden, H.J. & Mathijssen, I.M.J. (2012). Assessing
Nonacceptance of the Facial Appearance in Adult Patients After Complete Treatment of Their Rare
Facial Cleft. Aesthetic Plastic Surgery, 36(4), 938-945.
Elzen, M.E.P. van den, Versnel, S.L., Perry, J.C., Mathijssen, I.M.J. & Duivenvoorden, H.J. (2012).
Defense Mechanisms in Congenital and Acquired Facial Disfigurement A Clinical-Empirical Study.
Journal of Nervous and Mental Disease, 200(4), 323-328.
Jong, M. de, Lucas, C, Boelhouwer, H.H., Adrichem, L.N.A. van, Tibboel, D. & Dijk, M. van (2012). Does
postoperative 'M' technique (R) massage with or without mandarin oil reduce infants' distress after
major craniofacial surgery? Journal of Advanced Nursing, 68(8), 1748-1757.
Jong, T. de, Rijken, B.F.M., Lequin, M.H., Veelen, M.L.C. van & Mathijssen, I.M.J. (2012). Brain and
ventricular volume in patients with syndromic and complex craniosynostosis. Childs Nervous System,
28(1), 137-140.
Jong, T. de, Maliepaard, M., Bannink, N., Raat, H. & Mathijssen, I.M.J. (2012). Health-related problems
and quality of life in patients with syndromic and complex craniosynostosis. Childs Nervous System,
28(6), 879-882.
Kan, H.J. & Hovius, S.E.R. (2012). Long-term follow-up of flaps for extensive Dupuytren's and
Ledderhose disease in one family. Journal of Plastic, Reconstructive & Aesthetic Surgery, 65(12),
1741-1745.
Korstanje, J.H., Soeters, J.N.M., Schreuders, A.R., Amadio, PC, Hovius, S.E.R., Stam, H.J. & Selles, R.W.
(2012). Ultrasonographic Assessment of Flexor Tendon Mobilization: Effect of Different Protocols on
Tendon Excursion. Journal of Bone and Joint Surgery-American Volume, 94A(5), 394-402.
Korstanje, J.H., Boer, MF de, Blok, J.H., Amadio, PC, Hovius, S.E.R., Stam, H.J. & Selles, R.W. (2012).
Ultrasonographic assessment of longitudinal median nerve and hand flexor tendon dynamics in carpal
tunnel syndrome. Muscle & Nerve, 45(5), 721-729.
Krijgh, D.D. & Mureau, M.A.M. (2012). Aesthetic and Functional Outcome Following Perioral Defect
Reconstruction Using the Facial Artery Perforator Flap. Journal of Reconstructive Microsurgery, 28(8),
529-537.
Locke, MB, Zhong, T, Mureau, M.A.M. & Hofer, S.O.P. (2012). Tug 'O' war: Challenges of transverse
upper gracilis (TUG) myocutaneous free flap breast reconstruction. Journal of Plastic, Reconstructive
& Aesthetic Surgery, 65(8), 1041-1050.
Erasmus MC – Research Annual Report 2012
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Maarse, W, Rozendaal, A.M., Pajkrt, E, Vermeij-Keers, C., Molen, ABM van der & Boogaard, MJH van
den (2012). A systematic review of associated structural and chromosomal defects in oral clefts: when
is prenatal genetic analysis indicated? Journal of Medical Genetics, 49(8), 490-498.
Mathijssen, I.M.J. (2012). Invited commentary. Journal of Plastic, Reconstructive
65(4), 473-473.
& Aesthetic Surgery,
Meek, M.F. & Coert, J.H. (2012). Re: Chiriac et al. Experience of using the bioresorbable copolyester
poly(DL-lactide-epsilon-caprolactone) nerve conduit guide Neurolac (TM) for nerve repair in peripheral
nerve defects: report on a series of 28 lesions. J Hand Surg Eur. 2011, 37: 342-9. Journal of Hand
Surgery-European Volume, 37E(7), 702-704.
Meulen, J.C. van der (2012). Metopic synostosis. Childs Nervous System, 28(9), 1359-1367.
Michielsen, M.E., Selles, R.W., Stam, H.J., Ribbers, G.M. & Bussmann, J.B.J. (2012). Quantifying
Nonuse in Chronic Stroke Patients: A Study Into Paretic, Nonparetic, and Bimanual Upper-Limb Use in
Daily Life. Archives of Physical Medicine and Rehabilitation, 93(11), 1975-1981.
Nout, E., Bannink, N., Koudstaal, M.J., Veenland, J.F., Joosten, K.F.M., Poublon, R.M.L., Wal, K.G.H.
van der, Mathijssen, I.M.J. & Wolvius, E.B. (2012). Upper airway changes in syndromic craniosynostosis
patients following midface or monobloc advancement: Correlation between volume changes and
respiratory outcome. Journal of Cranio-Maxillofacial Surgery, 40(3), 209-214.
Ongkosuwito, E.M., Goos, J.A.C., Wattel, E, Wal, K.G.H. van der, Adrichem, L.N.A. van & Neck, J.W. van
(2012). Assessment of Volumetric Changes With a Best-Fit Method in Three-Dimensional
Stereophotograms. Cleft Palate-Craniofacial Journal, 49(4), 472-476.
Plomp, R.G., Bredero-Boelhouwer, H.H., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L. &
Mathijssen, I.M.J. (2012). Obstructive sleep apnoea in Treacher Collins syndrome: prevalence, severity
and cause. International Journal of Oral and Maxillofacial Surgery, 41(6), 696-701.
Plomp, R.G., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L., Montfort, C.A.G.M. van,
Bredero-Boelhouwer, H.H. & Mathijssen, I.M.J. (2012). Screening for obstructive sleep apnea in
treacher-collins syndrome. Laryngoscope, 122(4), 930-934.
Putter, C.E. de, Selles, R.W., Polinder, S., Panneman, MJM, Hovius, S.E.R. & Beeck, E.F. van (2012).
Economic impact of hand and wrist injuries: Health-care costs and productivity costs in a
population-based study. Journal of Bone and Joint Surgery-American Volume, 94(9).
Reitsma, JH, Ongkosuwito, E.M., Buschang, PH & Prahl - Andersen, B (2012). Facial Growth in Patients
With Apert and Crouzon Syndromes Compared to Normal Children. Cleft Palate-Craniofacial Journal,
49(2), 185-193.
Rozendaal, A.M., Luijsterburg, A.J.M., Ongkosuwito, E.M., Boogaard, MJH van den, Vries, E. de, Hovius,
S.E.R. & Vermeij-Keers, C. (2012). Delayed diagnosis and underreporting of congenital anomalies
associated with oral clefts in the Netherlands: A national validation study. Journal of Plastic,
Reconstructive & Aesthetic Surgery, 65(6), 780-790.
Rozendaal, A.M., Mohangoo, A.D., Ongkosuwito, E.M., Buitendijk, S.E., Bakker, MK & Vermeij-Keers, C.
(2012). Regional Variation in Prevalence of Oral Cleft Live Births in the Netherlands 1997-2007:
Time-Trend Analysis of Data from Three Dutch Registries. American Journal of Medical Genetics Part A,
158A(1), 66-74.
Rozendaal, A.M., Luijsterburg, A.J.M., Mohangoo, A.D., Ongkosuwito, E.M., Vries, E. de &
Vermeij-Keers, C. (2012). Validation of the Dutch Registry of Common Oral Clefts: Quality of Recording
Specific Oral Cleft Features. Cleft Palate-Craniofacial Journal, 49(5), 609-617.
Erasmus MC – Research Annual Report 2012
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Singh, HP, Dias, JJ, Slijper, H. & Hovius, S.E.R. (2012). Assessment of Velocity, Range, and Smoothness
of Wrist Circumduction Using Flexible Electrogoniometry. Journal of Hand Surgery-American Volume,
37A(11), 2331-2339.
Spiegelberg, L., Djasim, U.M., Neck, J.W. van, Wolvius, E.B. & Wal, K.G.H. van der (2012). The effects
of heparan sulphate mimetic RGTA-OTR4120 on irradiated murine salivary glands. Journal of Oral
Pathology & Medicine, 41(6), 477-483.
Tong, M., Tuk, B., Shang, P., Hekking, IM, Fijneman, E.M.G., Guijt, M, Hovius, S.E.R. & Neck, J.W. van
(2012). Diabetes-Impaired Wound Healing Is Improved by Matrix Therapy With Heparan Sulfate
Glycosaminoglycan Mimetic OTR4120 in Rats. Diabetes, 61(10), 2633-2641.
Tra, W.M.W., Neck, J.W. van, Hovius, S.E.R., Osch, G.J.V.M. van & Perez-Amodio, S (2012).
Characterization of a Three-Dimensional Mucosal Equivalent: Similarities and Differences with Native
Oral Mucosa. Cells Tissues Organs, 195(3), 185-196.
Ulrich, D.J.O., Ulrich, F., Doorn, L. van & Hovius, S.E.R. (2012). Lipofilling of Perineal and Vaginal Scars:
A New Method for Improvement of Pain after Episiotomy and Perineal Laceration. Plastic and
Reconstructive Surgery, 129(3), 593E-594E.
Veelen, M.L.C. van & Mathijssen, I.M.J. (2012). Spring-assisted correction of sagittal suture synostosis.
Childs Nervous System, 28(9), 1347-1351.
Verseijden, F., Sluijs, S.J. van, Neck, J.W. van, Hofer, S.O.P., Hovius, S.E.R. & Osch, G.J.V.M. van
(2012). Vascularization of prevascularized and non-prevascularized fibrin-based human adipose tissue
constructs after implantation in nude mice. Journal of Tissue Engineering and Regenerative Medicine,
6(3), 169-178.
Versnel, S.L., Plomp, R.G., Passchier, J., Duivenvoorden, H.J. & Mathijssen, I.M.J. (2012). Long-Term
Psychological Functioning of Adults with Severe Congenital Facial Disfigurement. Plastic and
Reconstructive Surgery, 129(1), 110-117.
Viddeleer, AR, Sijens, PE, Ooyen, PMA van, Kuypers, P.D.L., Hovius, S.E.R. & Oudkerk, M.. (2012).
Sequential MR Imaging of Denervated and Reinnervated Skeletal Muscle as Correlated to Functional
Outcome. Radiology, 264(2), 522-530.
Vlugt, J.J.B. van der, Meulen, J.J.N.M. van der, Creemers, H.E., Verhulst, F.C., Hovius, S.E.R. &
Okkerse, J.M.E. (2012). Cognitive and Behavioral Functioning in 82 Patients with Trigonocephaly.
Plastic and Reconstructive Surgery, 130(4), 885-893.
Voshol, I.E., Wal, K.G.H. van der, Adrichem, L.N.A. van, Ongkosuwito, E.M. & Koudstaal, M.J. (2012).
The Frequency of Le Fort I Osteotomy in Cleft Patients. Cleft Palate-Craniofacial Journal, 49(2),
160-166.
Zuidam, J.M., Selles, R.W. & Hovius, S.E.R. (2012). Thumb strength in all types of triphalangeal thumb.
Journal of Hand Surgery-European Volume, 37E(8), 751-754.
Part of book - Abstract
Neck, J.W. van, Tuk, B., Barritault, D & Tong, M. (2012). Heparan sulfate proteoglycan mimetics
promote tissue regeneration: an overvieuw. In J. Davies (Ed.), Tissue Regeneration - from basic biology
to clinical application. --: InTech.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-01-64-01 - Epidemiology of diseases
Programme (brief description)
This program includes scientific research in cardiovascular epidemiology, neuroepidemiology and
ophthalmologic epidemiology. Cardiovascular epidemiologic research focuses on the determinants of
atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women.
The research is based on the Rotterdam Study and addresses inflammation markers and hemostasis as
determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous
hormones and hormone replacement therapy in women. Neuroepidemiologic research focuses on the
etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's
disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the
role of vascular factors in the etiology of these diseases, with use of state of the art neuroimaging
techniques. Ophthalmological epidemiologic research focuses on determinants of macula degeneration
and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in etiology of
these diseases.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
epidemiology
pediatric
psychiatry
4,05
7,1
2,58
3,72
17,45
0,11
0,26
Total
4,16
7,36
T1
T2
T3
Ttot
4
0
0
4
IS
FS
OP
Ptot
189
11
0
204
0,37
2,58
3,72
17,82
Thesis
Elias-Smale, S.E. (2012, januari 18). Coronary artery calcification and cardiovascular risk prediction.
EUR. Prom./coprom.: Prof. Dr. J.C.M. Witteman & Prof. Dr. A. van der Lugt.
Koppelmans, V. (2012, april 20). Late effects of adjuvant chemotherapy on brain function and
structure. EUR. Prom./coprom.: Prof. Dr. M.M.B. Breteler.
Walter, S. (2012, januari 18). Determinants of healthy ageing: studies of disability and survival among
the elder. EUR (265 pag.). Prom./coprom.: Prof. Dr. J.P. Mackenbach & Prof. Dr. A. Hofman.
Wieberdink, R.G. (2012, maart 01). Determinants of cerebral infarction and intracerebral hemorrhage;
the Rotterdam Study. EUR. Prom./coprom.: Prof. Dr. M.M.B. Breteler, Prof. Dr. P.J. Koudstaal & Dr.
M.A. Ikram.
Article/Letter to the editor
Alssema, M, Newson, R.S., Bakker, SJL, Stehouwer, C.D.A., Heymans, M.W., Nijpels, G., Hillege, H.L.,
Hofman, A., Witteman, J.C.M., Gansevoort, RT & Dekker, J.M. (2012). One Risk Assessment Tool for
Cardiovascular Disease, Type 2 Diabetes, and Chronic Kidney Disease. Diabetes Care, 35(4), 741-748.
Amin, N., Byrne, E, Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I.M., Vink, J.M., Rawal, R,
Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N,
Doering, A, Isaacs, A, Broer, L., Wray, NR, Montgomery, GW, Levy, D., Psaty, B.M., Gudnason, V,
Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, Rooij,
F.J.A. van, Aulchenko, Y.S., Hottenga, J.J., Rivadeneira, FR, Hofman, A., Uitterlinden, A.G., Hammond,
CJ, Shin, SY, Ikram, A., Witteman, J.C.M., Janssens, A.C.J.W., Snieder, H, Tiemeier, H.W.,
Wolfenbuttel, BHR, Oostra, B.A., Heath, AC, Wichmann, E, Spector, T.D., Grabe, HJ, Boomsma, D.I.,
Martin, NG & Duijn, C.M. van (2012). Genome-wide association analysis of coffee drinking suggests
association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17(11), 1116-1129.
Erasmus MC – Research Annual Report 2012
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Anchala, R, Pant, H, Prabhakaran, D & Franco Duran, O.H. (2012). 'Decision support system (DSS) for
prevention of cardiovascular disease (CVD) among hypertensive (HTN) patients in Andhra Pradesh,
India' - a cluster randomised community intervention trial. Bmc Public Health, 12.
Anchala, R, Pinto, MP, Shroufi, A, Chowdhury, R, Sanderson, J, Johnson, L., Blanco, P, Prabhakaran, D
& Franco, O.H. (2012). The Role of Decision Support System (DSS) in Prevention of Cardiovascular
Disease: A Systematic Review and Meta-Analysis. PLoS One, 7(10).
Angelantonio, E Di, Gao, P, Pennells, L, Kaptoge, S, Caslake, M, Thompson, A, Butterworth, AS, Sarwar,
N, Wormser, D, Saleheen, D, Ballantyne, C.M., Psaty, B.M., Sundstrom, J, Ridker, P.M., Nagel, D,
Gillum, RF, Ford, I, Ducimetiere, P, Kiechl, S, Dullaart, R.P.F., Assmann, G., D'Agostino, RB, Dagenais,
GR, Cooper, JA, Kromhout, D., Onat, A, Tipping, RW, Gomez-de-la-Camara, A, Rosengren, A,
Sutherland, SE, Gallacher, J, Fowkes, FGR, Casiglia, E, Hofman, A., Salomaa, V, Barrett-Connor, E,
Clarke, R., Brunner, E, Jukema, J.W., Simons, LA, Sandhu, M, Wareham, NJ, Khaw, KT, Kauhanen, J,
Salonen, J.T., Howard, WJ, Nordestgaard, BG, Wood, AM, Thompson, SG, Boekholdt, S.M., Sattar, N,
Packard, C, Gudnason, V & Danesh, J (2012). Lipid-Related Markers and Cardiovascular Disease
Prediction. Jama - Journal of the American Medical Association, 307(23), 2499-2506.
Baas, DC, Ho, L., Tanck, M.W.T., Fritsche, LG, Merriam, JE, Slot, R van 't, Koeleman, B.P.C., Gorgels,
T.G.M.F., Duijn, C.M. van, Uitterlinden, A.G., Jong, P.T.V.M. de, Hofman, A., Brink, J.B., Vingerling, J.R.,
Klaver, C.C.W., Dean, M, Weber, BHF, Allikmets, R., Hageman, G.S. & Bergen, A.A.B. (2012).
Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related
macular degeneration. Molecular Vision, 18(72), 657-674.
Barral, S, Fernandez-Cadenas, I, Bis, JC, Montaner, J, Ikram, M.A., Launer, L.J., Fornage, M, Schmidt,
H., Brickman, AM, Seshadri, S & Mayeux, R. (2012). No association of ALOX5AP polymorphisms with
risk of MRI-defined brain infarcts. Neurobiology of Aging, 33(3).
Bergen, N, Jaddoe, V.W.V.K., Timmermans, S., Hofman, A., Lindemans, J., Russcher, H., Raat, H.,
Steegers-Theunissen, R.P.M. & Steegers, E.A.P. (2012). Homocysteine and folate concentrations in
early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. Bjog-An
International Journal of Obstetrics and Gynaecology, 119(6), 739-751.
Bergen, N.E., Jaddoe, V.W.V.K., Timmermans, S., Hofman, A., Lindemans, J., Russcher, H., Raat, H.,
Steegers-Theunissen, R.P.M. & Steegers, E.A.P. (2012). Understanding health behaviours in a cohort of
pregnant women at risk of gestational diabetes mellitus: an observational study. Bjog-An International
Journal of Obstetrics and Gynaecology, 119(6), 739-751.
Betancourt, MCC, Cailotto, F, Kerkhof, HJ, Cornelis, FMF, Doherty, SA, Hart, D.J., Hofman, A., Luyten,
FP, Maciewicz, RA, Mangino, M, Metrustry, S, Muir, K, Peters, M.J., Rivadeneira, F., Wheeler, M, Zhang,
WY, Arden, N, Spector, T.D., Uitterlinden, A.G., Doherty, M, Lories, RJU, Valdes, A.M. & Meurs, J.B.J.
van (2012). Genome-wide association and functional studies identify the DOT1L gene to be involved in
cartilage thickness and hip osteoarthritis. Proceedings of the National Academy of Sciences of the
United States of Ame, 109(21), 8218-8223.
Bis, JC, DeCarli, C., Smith, AV, Lijn, F. van der, Crivello, F, Fornage, M, Debette, S, Shulman, JM,
Schmidt, H., Srikanth, V, Schuur, M., Yu, L, Choi, SH, Sigurdsson, S, Verhaaren, B.F.J., DeStefano, AL,
Lambert, JC, Jack, CR, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, CA, Fleischman, D, Zijdenbos, A.,
Heijer, T. den, Mazoyer, B, Coker, LH, Enzinger, C, Danoy, P, Amin, N., Arfanakis, K, Buchem, M.A. van,
Bruijn, R.F.A.G. de, Beiser, A, Dufouil, C., Huang, JB, Cavalieri, M, Thomson, R, Niessen, W.J., Chibnik,
LB, Gislason, GK, Hofman, A., Pikula, A, Amouyel, P, Freeman, KB, Phan, TG, Oostra, B.A., Stein, JL,
Medland, SE, Vasquez, AA, Hibar, DP, Wright, MJ, Franke, B., Martin, NG, Thompson, PM, Nalls, MA,
Uitterlinden, A.G., Au, R., Elbaz, A., Beare, RJ, Swieten, J.C. van, Lopez, OL, Harris, T.B., Chouraki, V,
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Tas, U., Verhagen, A.P., Bierma-Zeinstra, S.M.A., Hofman, A., Pols, H.A.P. & Koes, B.W. (2012). Course
and prognostic factors of disability in community-dwelling older people with mild disability: The
Rotterdam Study. AUSTRALASIAN JOURNAL ON AGEING, 31(1), 28-33.
Tharner, A., Luijk, P.C.M., Raat, H., Ijzerdoorn, M.H. van, Bakermans-Kranenburg, MJ, Moll, H.A.,
Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2012). Breastfeeding and Its Relation
Erasmus MC – Research Annual Report 2012
< back to index
to Maternal Sensitivity and Infant Attachment. Journal of Developmental and Behavioral Pediatrics,
33(5), 396-404.
Tharner, A., Luijk, P.C.M., Ijzerdoorn, M.H. van, Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K.,
Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2012). Maternal lifetime history of depression and
depressive symptoms in the prenatal and early postnatal period do not predict infant-mother
attachment quality in a large, population-based Dutch cohort study. ATTACHMENT & HUMAN
DEVELOPMENT, 14(1), 63-81.
Thiadens, A.A.H.J., Phan, TML, Zekveld-Vroon, RC, Leroy, BP, Born, L.I. van den, Hoyng, C.B., Klaver,
C.C.W., Roosing, S, Pott, JWR, Schooneveld, MJ van, Moll-Ramirez, N van, Genderen, MM van, Boon,
CJF, Hollander, A.I., Bergen, A.A.B., Baere, E De, Cremers, F.P.M. & Lotery, AJ (2012). Clinical Course,
Genetic Etiology, and Visual Outcome in Cone and Cone-Rod Dystrophy. Ophthalmology, 119(4),
819-826.
Thiadens, A.A.H.J., Slingerland, N.W.R., Florijn, RJ, Visser, G.H., Riemslag, F.C. & Klaver, C.C.W.
(2012). Cone-rod dystrophy can be a manifestation of Danon disease. Graefes Archive for Clinical and
Experimental Ophthalmology, 250(5), 769-774.
Tiemeier, H.W., Velders, F.P., Szekely, E., Roza, S.J., Dieleman, G.C., Jaddoe, V.W.V.K., Uitterlinden,
A.G., White, T.J.H., Bakermans-Kranenburg, MJ, Hofman, A., IJzendoorn, M.H. van, Hudziak, J.J. &
Verhulst, F.C. (2012). The Generation R Study: A Review of Design, Findings to Date, and a Study of the
5-HTTLPR by Environmental Interaction From Fetal Life Onward. Journal of the American Academy
Child Adolescent Psychiatry, 51(11), 1119-1135.
Timmermans, S., Steegers-Theunissen, R.P.M., Vujkovic, M., Breeijen, H Den, Russcher, H.,
Lindemans, J., Mackenbach, J.P., Hofman, A., Lesaffre, EE, Jaddoe, V.W.V.K. & Steegers, E.A.P. (2012).
The Mediterranean diet and fetal size parameters: the Generation R Study. British Journal of Nutrition,
108(8), 1399-1409.
Traylor, M, Farrall, M, Holliday, EG, Sudlow, C, Hopewell, JC, Cheng, YC, Fomage, M, Ikram, M.A.,
Malik, R, Bevan, S, Thorsteinsdottir, U, Nalls, MA, Longstreth, W.T., Wiggins, KL, Yadav, S, Parati, EA,
DeStefano, AL, Worrall, BB, Kittner, S, Khan, MS, Reiner, AP, Helgadottir, A, Achterberg, S,
Fernandez-Cadenas, I, Abboud, S, Schmidt, R., Walters, M., Chen, WM, Ringelstein, EB, O'Donnell, M,
Ho, WK, Pera, J, Lemmens, R, Norrving, B, Higgins, P, Benn, M, Sale, M, Kuhlenbaumer, G, Doney, ASF,
Vicente, AM, Delavaran, H, Algra, A., Davies, G., Oliveira, SA, Palmer, CNA, Deary, I, Schmidt, H.,
Pandolfo, M, Montaner, J, Carty, C, Bakker, PIW de, Kostulas, K, Ferro, JM, Zuydam, NR van,
Valdimarsson, E, Nordestgaard, BG, Lindgren, A, Thijs, V, Slowik, A, Saleheen, D, Pare, G, Berger, K.,
Thorleifsson, G, Hofman, A., Mosley, TH, Mitchell, B.D., Furie, K, Clarke, R., Levi, C, Seshadri, S,
Gschwendtner, A, Boncoraglio, GB, Sharma, P., Bis, JC, Gretarsdottir, S, Psaty, B.M., Rothwell, P.M.,
Rosand, J, Meschia, JF, Stefansson, K, Dichgans, M & Markus, HS (2012). Genetic risk factors for
ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide
association studies. Lancet Neurology, 11(11), 951-962.
Tripepi, G, Mattace Raso, F.U.S., Pizzini, P, Cutrupi, S, Witteman, J.C.M., Zoccali, C & Mallamaci, F
(2012). Smoking and hyperparathyroidism in patients with end-stage renal disease (ESRD). Journal of
Nephrology, 25(1), 75-83.
Tromp, I.I.M., Kiefte- de Jong, J.C., Vries, J.H. de, Jaddoe, V.W.V.K., Raat, H., Hofman, A., Jongste,
J.C. de & Moll, H.A. (2012). Dietary patterns and respiratory symptoms in pre-school children: the
Generation R Study. European Respiratory Journal, 40, 681-689.
Tuinenburg, A, Rutten, A, Kavousi, M., Leebeek, F.W.G., Ypma, PF, Gorkom, BAP Laros-Van, Nijziel,
MR, Kamphuisen, P.W., Mauser-Bunschoten, E.P., Roosendaal, G, Biesma, D.H., Lugt, A. van der,
Hofman, A., Witteman, J.C.M., Bots, M.L. & Schutgens, REG (2012). Coronary Artery Calcification in
Hemophilia A No Evidence for a Protective Effect of Factor VIII Deficiency on Atherosclerosis.
Arteriosclerosis Thrombosis & Vascular Biology, 32(3), 799-804.
Erasmus MC – Research Annual Report 2012
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Tyrrell, J, Huikari, V, Christie, JT, Cavadino, A, Bakker, R., Brion, MJA, Geller, F, Paternoster, L, Myhre,
R, Potter, C, Johnson, PCD, Ebrahim, S, Feenstra, B, Hartikainen, AL, Hattersley, A.T., Hofman, A.,
Kaakinen, M, Lowe, LP, Magnus, P, McConnachie, A, Melbye, M, Ng, JWY, Nohr, EA, Power, C, Ring, SM,
Sebert, SP, Sengpiel, V, Taal, H.R., Watt, GCM, Sattar, N, Relton, CL, Jacobsson, B, Frayling, T.M.,
Srensen, TIA, Murray, JC, Lawlor, DA, Pennell, CE, Jaddoe, V.W.V.K., Hypponen, E, Lowe, WL, Jarvelin,
MR, Smith, G.D. & Freathy, RM (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor
gene cluster (CHRNA5CHRNA3CHRNB4) interacts with maternal self-reported smoking status during
pregnancy to influence birth weight. Human Molecular Genetics, 21(24), 5344-5358.
Uh, HW, Deelen, J, Beekman, M, Helmer, Q, Rivadeneira, F., Hottenga, J.J., Boomsma, D.I., Hofman,
A., Uitterlinden, A.G., Slagboom, P.E., Bohringer, S & Houwing-Duistermaat, J.J. (2012). How to deal
with the early GWAS data when imputing and combining different arrays is necessary. European Journal
of Human Genetics, 20(5), 572-576.
Valk, R.J.P. van der, Duijts, L., Kerkhof, M., Willemsen, S.P., Hofman, A., Moll, H.A., Smit, H.A.,
Brunekreef, B., Postma, D.S., Jaddoe, V.W.V.K., Koppelman, G.H. & Jongste, J.C. de (2012).
Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of
childhood asthma-like symptoms. Allergy, 67(6), 767-774.
Velders, F.P., Wit, JE De, Jansen, P.W., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W.
(2012). FTO at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in
Preschool Children. PLoS One, 7(11).
Velders, F.P., Dieleman, G.C., Cents, R.A.M., Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K., Hofman,
A., Ijzerdoorn, M.H. van, Verhulst, F.C. & Tiemeier, H.W. (2012). Variation in the Glucocorticoid
Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on
Child Cortisol Reactivity and Behavior. Neuropsychopharmacology, 37(11), 2541-2549.
Ven, JPH van de, Boon, CJF, Fauser, S, Hoefsloot, LH, Smailhodzic, D, Schoenmaker-Koller, F,
Klevering, B.J., Klaver, C.C.W., Hollander, A.I. & Hoyng, C.B. (2012). Clinical Evaluation of 3 Families
With Basal Laminar Drusen Caused by Novel Mutations in the Complement Factor H Gene. Archives of
Ophthalmology, 130(8), 1038-1047.
Verhoeven, V.J.M., Hysi, PG, Saw, SM, Vitart, V, Mirshahi, A, Guggenheim, JA, Cotch, MF, Yamashiro, K,
Baird, PN, Mackey, DA, Wojciechowski, R, Ikram, M.K., Hewitt, AW, Duggal, P, Janmahasatian, S, Khor,
C.C., Fan, Q, Zhou, X., Young, TL, Tai, ES, Goh, LK, Li, YJ, Aung, T, Vithana, E, Teo, YY, Tay, W, Sim, X,
Rudan, I, Hayward, C, Wright, AF, Polasek, O, Campbell, H, Wilson, JF, Fleck, BW, Nakata, I,
Yoshimura, N, Yamada, R, Matsuda, F, Ohno-Matsui, K, Nag, A, McMahon, G, Pourcain, B St, Lu, Y.,
Rahi, JS, Cumberland, PM, Bhattacharya, S, Simpson, CL, Atwood, LD, Li, XH, Raffel, LJ, Murgia, F,
Portas, L, Despriet, D.D.G., Koolwijk, L.M.E. van, Wolfram, C, Lackner, KJ, Tonjes, A, Magi, R,
Lehtimaki, T, Kahonen, M, Esko, T, Metspalu, A, Rantanen, T, Parssinen, O, Klein, BE, Meitinger, T,
Spector, T.D., Oostra, B.A., Smith, AV, Jong, P.T.V.M. de, Hofman, A., Amin, N., Karssen, L.C.,
Rivadeneira, F., Vingerling, J.R., Eiriksdottir, G, Gudnason, V, Doring, A, Bettecken, T, Uitterlinden,
A.G., Williams, C., Zeller, T, Castagne, R, Oexle, K, Duijn, C.M. van, Iyengar, SK, Mitchell, P., Wang,
J.J., Hohn, R, Pfeiffer, N, Bailey-Wilson, JE, Stambolian, D, Wong, TY, Hammond, CJ & Klaver, C.C.W.
(2012). Large scale international replication and meta-analysis study confirms association of the 15q14
locus with myopia. The CREAM consortium. Human Genetics, 131(9), 1467-1480.
Verlinden, M., Tiemeier, H.W., Hudziak, J.J., Jaddoe, V.W.V.K., Raat, H., Guxens, M, Hofman, A.,
Verhulst, F.C. & Jansen, P.W. (2012). Television Viewing and Externalizing Problems in Preschool
Children The Generation R Study. Archives of Pediatrics & Adolescent Medicine, 166(10), 919-925.
Verwoert, G.C., Elias-Smale, S.E., Rizopoulos, D., Koller, M.T., Steyerberg, E.W., Hofman, A., Kavousi,
M., Sijbrands, E.J.G., Hoeks, A.P.G., Reneman, R.S., Mattace Raso, F.U.S. & Witteman, J.C.M. (2012).
Does aortic stiffness improve the prediction of coronary heart disease in elderly? The Rotterdam Study.
Journal of Human Hypertension, 26(1), 28-34.
Erasmus MC – Research Annual Report 2012
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Visser, A.M., Jaddoe, V.W.V.K., Ghassabian, A., Schenk, J.J.A.M., Verhulst, F.C., Hofman, A., Tiemeier,
H.W., Moll, H.A. & Arts, W.F.M. (2012). Febrile seizures and behavioural and cognitive outcomes in
preschool childrenL the Generation R Study. Developmental Medicine & Child Neurology, 54,
1006-1011.
Visser, A.M., Jaddoe, V.W.V.K., Breteler, M.M.B., Hofman, A. & Arts, W.F.M. (2012). Frequent fever
episodes and the risk of febrile seizures: The Generation R Study. European Journal of Paediatric
Neurology, 16, 29-34.
Voort, A.M.M. van der, Jaddoe, V.W.V.K., Valk, R.J.P. van der, Willemsen, S.P., Hofman, A., Moll, H.A.,
Jongste, J.C. de & Duijts, L. (2012). Duration and exclusiveness of breastfeeding and childhood
asthma-related symptoms. European Respiratory Journal, 39, 81-89.
Voort, A.M.M. van der, Jaddoe, V.W.V.K., Raat, H., Moll, H.A., Hofman, A., Jongste, J.C. de & Duijts, L.
(2012). Fetal and Infant Growth and Asthma Symptoms in Preschool Children The Generation R Study.
American Journal of Respiratory and Critical Care Medicine, 185(7), 731-737.
Walter, S., Mackenbach, J.P., Voko, Z., Lhachimi, S.K., Ikram, M.A., Uitterlinden, A.G., Newman, AB,
Murabito, JM, Garcia, ME, Gudnason, V, Tanaka, T, Tranah, GJ, Wallaschofski, H., Kocher, T, Launer,
L.J., Franceschini, N, Schipper, M., Hofman, A. & Tiemeier, H.W. (2012). Genetic, physiological, and
lifestyle predictors of mortality in the general population. American Journal of Public Health, 102(4),
3-10.
Wieberdink, R.G., Koudstaal, P.J., Hofman, A., Witteman, J.C.M., Breteler, M.M.B. & Ikram, M.A.
(2012). Insulin Resistance and the Risk of Stroke and Stroke Subtypes in the Nondiabetic Elderly.
American Journal of Epidemiology, 176(8), 699-707.
Wieberdink, R.G., Ikram, M.A., Hofman, A., Koudstaal, P.J. & Breteler, M.M.B. (2012). Trends in stroke
incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008. European
Journal of Epidemiology, 27(4), 287-295.
Wijtzes, A.I., Jansen, W., Kamphuis, C.B.M., Jaddoe, V.W.V.K., Moll, H.A., Tiemeier, H.W., Verhulst,
F.C., Hofman, A., Mackenbach, J.P. & Raat, H. (2012). Increased risk of exceeding
entertainment-media guidelines in preschool children from low socioeconomic background: The
Generation R Study. Preventive Medicine, 55, 325-329.
Wilk, JB, Shrine, NRG, Loehr, LR, Zhao, JH, Manichaikul, A, Lopez, LM, Smith, AV, Heckbert, SR,
Smolonska, J, Tang, WB, Loth, D.W., Curjuric, I, Hui, J, Cho, MH, Latourelle, JC, Henry, AP, Aldrich, M,
Bakke, P, Beaty, TH, Bentley, AR, Borecki, IB, Brusselle, GG, Burkart, KM, Chen, TH, Couper, D, Crapo,
JD, Davies, G., Dupuis, J, Franceschini, N, Gulsvik, A, Hancock, DB, Harris, T.B., Hofman, A., Imboden,
M, James, AL, Khaw, KT, Lahousse, L, Launer, L.J., Litonjua, A, Liu, YM, Lohman, KK, Lomas, DA,
Lumley, T, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, Musk, AW, Myers, R.H., North, KE,
Postma, D.S., Psaty, B.M., Rich, SS, Rivadeneira, F., Rochat, T, Rotter, JI, Artigas, MS, Starr, JM,
Uitterlinden, A.G., Wareham, NJ, Wijmenga, C., Zanen, P, Province, MA, Silverman, EK, Deary, IJ,
Palmer, LJ, Cassano, PA, Gudnason, V, Barr, RG, Loos, RJF, Strachan, DP, London, SJ, Boezen, H.M.,
Probst-Hensch, N, Gharib, SA, Hall, IP, O'Connor, GT, Tobin, MD & Stricker, B.H.C. (2012).
Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow
Obstruction. American Journal of Respiratory and Critical Care Medicine, 186(7), 622-632.
Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Jaddoe, V.W.V.K., Hofman, A., Raat, H., Verhulst, F.C.,
Passchier, J. & Tiemeier, H.W. (2012). Concurrent and Longitudinal Bidirectional Relationships Between
Toddlers' Chronic Pain and Mental Health: The Generation R Study. Journal of Pediatric Psychology,
37(5), 546-556.
Woudenbergh, GJ van, Kuijsten, A, Tigcheler, B, Sijbrands, E.J.G., Rooij, F.J.A. van, Hofman, A.,
Witteman, J.C.M. & Feskens, E.J.M. (2012). Meat Consumption and Its Association With C-Reactive
Protein and Incident Type 2 Diabetes The Rotterdam Study. Diabetes Care, 35(7), 1499-1505.
Erasmus MC – Research Annual Report 2012
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Xia, MF, Lin, HD, Li, XM, Yan, H.M., Bian, H, Chang, XX, He, WY, Jeekel, J., Hofman, A. & Gao, X (2012).
Renal function-dependent association of serum uric acid with metabolic syndrome and hepatic fat
content in a middle-aged and elderly Chinese population. Clinical & Experimental Pharmacology and
Physiology, 39(11), 930-937.
Yang, J., Loos, RJ, Powell, JE, Medland, SE, Speliotes, EK, Chasman, DI, Rose, LM, Thorleifsson, G,
Steinthorsdottir, V, Magi, R, Waite, LL, Smith, AV, Yerges-Armstrong, LM, Monda, KL, Hadley, D,
Mahajan, A, Li, G, Kapur, K, Vitart, V, Huffman, JE, Wang, SR, Palmer, C, Esko, T, Fischer, K., Zhao, JH,
Demirkan, A., Isaacs, A.J., Feitosa, MF, Luan, J, Heard-Costa, NL, White, CC, Jackson, AU, Preuss, M,
Ziegler, A, Eriksson, J, Kutalik, Z, Frau, F, Nolte, I.M., Vliet-Ostaptchouk, JV van, Hottenga, J.J., Jacobs,
KB, Verweij, N., Goel, A, Medina Gomez, C., Estrada, K, Bragg-Gresham, JL, Sanna, S, Sidore, C, Tyrer,
J, Teumer, A, Prokopenko, I, Mangino, M, Lindgren, CM, Assimes, TL, Shuldiner, AR, Hui, J, Beilby, JP,
McArdle, WL, Hall, P., Hartitunians, T, Zgaga, L, Kolcic, I, Polasek, O, Zemunik, T, Oostra, B.A., Junttila,
MJ, Gronberg, H, Schreiber, S., Peters, A., Hicks, AA, Stephens, J, Foad, NS, Laitinen, J, Pouta, A,
Kaakinen, M, Willemsen, G, Vink, J.M., Wild, SH, Navis, G, Asselbergs, F.W., Homuth, G., John, U,
Iribarren, C, Harris, T, Launer, L, Gudnason, V, O'Connell, JR, Boerwinkel, E, Cadby, G, Palmer, LJ,
James, AL, Musk, AW, Ingelsson, E, Psaty, B.M., Beckmann, J.S., Waeber, G, Vollenweider, P, Hayward,
C, Wright, AF, Rudan, I, Groop, LC, Metspalu, A, Khaw, KT, Duijn, C.M. van, Borecki, I, Province, MA,
Wareham, NJ, Tardif, JC, Huikuri, HV, Cupples, L.A., Atwood, LD, Fox, CS, Boehnke, M, Collins, FS,
Mohlke, KL, Erdmann, J., Schunkert, H., Hengstenberg, C, Stark, K, Lorentzon, M, Ohlsson, C, Cusi, D,
Staessen, JA, Klauw, M.M. van der, Pramstaller, P.P., Kathiresan, S, Jolley, JD, Ripatti, S, Jarvelin, MR,
Geus, E.J.C. de, Boomsma, D.I., Penninx, B, Wilson, JF, Campbell, H, Chanock, SJ, Harst, P. van der,
Hamsten, A., Watkins, H, Hofman, A., Witteman, J.C.M., Zillikens, M.C., Uitterlinden, A.G., Rivadeneira
Ramirez, F., Kiemeney, L.A.L.M., Vermeulen, S.H.H.M., Abecasis, GR, Schlessinger, D, Schipf, S,
Stumvoll, M., Tonjes, A, Spector, T.D., North, KE, Lettre, G., McArthy, MI, Berndt, SI, Heath, AC,
Madden, PA, Nyholt, DR, Montgomery, GW, Martin, NG, McKnight, B, Strachan, DP, Hill, WG, Snieder,
H, Ridker, P.M., Thorsteinsdottir, U, Stefansson, K, Frayling, T.M., Hirschhorn, JN, Goddard, ME &
Visscher, P.M. (2012). FTO genotype is associated with phenotypic variability of body mass index.
Nature, 490, 267-272.
Zwirs, B, Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Mackenbach, J.P. & Tiemeier, H.W. (2012).
Partner similarity for self-reported antisocial behaviour among married, cohabiting and dating couples:
the Generation R Study. Psychology Crime & Law, 18(4), 335-349.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-01-64-02 - Basic epidemiologic research
Programme (brief description)
This program includes research in the fields of genetic epidemiology and endocrinologic
epidemiology. Genetic epidemiologic research aims at quantifying the population risk of
disorders associated with genetic risk factors and at identifying new genetic factors involved in
complex genetic disorders. For the empirical studies, the emphasis is on neurodegenerative and
neurovascular disorders. The work in endocrinologic epidemiology focuses on the question
whether circulating hormone levels are associated with incident diseases of the elderly and with
parameters of frailty. The emphasis is on determinants of locomotor diseases (osteoporosis,
osteoarthritis) and on sex hormones and thyroid hormones as determinants of disease.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
epidemiology
1,16
7,79
0,67
0,54
10,16
0,03
0,03
0,57
10,19
Generation R
Total
1,16
7,79
0,67
T1
T2
T3
Ttot
2
0
0
2
IS
116
FS
OP
Ptot
9
0
127
Thesis
Batenburg-Eddes, T. van (2012, september 27). Causes and consequences of infant neuromotor
development. The generation R study. EUR (207 pag.). Prom./coprom.: Prof.dr. H.W. Tiemeier & Prof.
Dr. F.C. Verhulst.
Velders, F.P. (2012, oktober 31). Genes, parental psychiatric symptons and child emotional problems.
EUR (201 pag.). Prom./coprom.: Prof.dr. H.W. Tiemeier & Prof. Dr. F.C. Verhulst.
Article/Letter to the editor
Alcalde-Cabero, E, Almazan-Isla, J, Brandel, JP, Breithaupt, M, Catarino, J, Collins, S., Hayback, J,
Hoftberger, R, Kahana, E, Kovacs, GG, Ladogana, A., Mitrova, E., Molesworth, A, Nakamura, Y,
Pocchiari, M., Popovic, M, Ruiz-Tovar, M, Taratuto, AL, Duijn, C.M. van, Yamada, M, Will, R.G., Zerr, I.
& Cuesta, JD (2012). Health professions and risk of sporadic Creutzfeldt-Jakob disease, 1965 to 2010.
Eurosurveillance, 17(15), 13-22.
Ameur, A, Enroth, S, Johansson, A, Zaboli, G, Igl, W, Johansson, ACV, Rivas, MA, Daly, M.J., Schmitz,
G., Hicks, AA, Meitinger, T, Feuk, L., Duijn, C.M. van, Oostra, B.A., Pramstaller, P.P., Rudan, I, Wright,
AF, Wilson, JF, Campbell, H & Gyllensten, U (2012). Genetic Adaptation of Fatty-Acid Metabolism: A
Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty
Acids. American Journal of Human Genetics, 90(5), 809-820.
Amin, N., Schuur, M., Gusareva, ES, Isaacs, A, Aulchenko, Y.S., Kirichenko, AV, Zorkoltseva, IV,
Axenovich, T.I., Oostra, B.A., Janssens, A.C.J.W. & Duijn, C.M. van (2012). A genome-wide linkage
study of individuals with high scores on NEO personality traits. Molecular Psychiatry, 17(10),
1031-1041.
Amin, N., Byrne, E, Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I.M., Vink, J.M., Rawal, R,
Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N,
Doering, A, Isaacs, A, Broer, L., Wray, NR, Montgomery, GW, Levy, D., Psaty, B.M., Gudnason, V,
Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, Rooij,
F.J.A. van, Aulchenko, Y.S., Hottenga, J.J., Rivadeneira, FR, Hofman, A., Uitterlinden, A.G., Hammond,
CJ, Shin, SY, Ikram, A., Witteman, J.C.M., Janssens, A.C.J.W., Snieder, H, Tiemeier, H.W.,
Wolfenbuttel, BHR, Oostra, B.A., Heath, AC, Wichmann, E, Spector, T.D., Grabe, HJ, Boomsma, D.I.,
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American Journal of Respiratory and Critical Care Medicine, 185(7), 731-737.
Walter, S., Mackenbach, J.P., Voko, Z., Lhachimi, S.K., Ikram, M.A., Uitterlinden, A.G., Newman, AB,
Murabito, JM, Garcia, ME, Gudnason, V, Tanaka, T, Tranah, GJ, Wallaschofski, H., Kocher, T, Launer,
L.J., Franceschini, N, Schipper, M., Hofman, A. & Tiemeier, H.W. (2012). Genetic, physiological, and
lifestyle predictors of mortality in the general population. American Journal of Public Health, 102(4),
3-10.
Wijtzes, A.I., Jansen, W., Kamphuis, C.B.M., Jaddoe, V.W.V.K., Moll, H.A., Tiemeier, H.W., Verhulst,
F.C., Hofman, A., Mackenbach, J.P. & Raat, H. (2012). Increased risk of exceeding
entertainment-media guidelines in preschool children from low socioeconomic background: The
Generation R Study. Preventive Medicine, 55, 325-329.
Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Jaddoe, V.W.V.K., Hofman, A., Raat, H., Verhulst, F.C.,
Passchier, J. & Tiemeier, H.W. (2012). Concurrent and Longitudinal Bidirectional Relationships Between
Toddlers' Chronic Pain and Mental Health: The Generation R Study. Journal of Pediatric Psychology,
37(5), 546-556.
Zaboli, G, Ameur, A, Igl, W, Johansson, A, Hayward, C, Vitart, V, Campbell, S, Zgaga, L, Polasek, O,
Schmitz, G., Duijn, C.M. van, Oostra, B.A., Pramstaller, P, Hicks, A, Meitinger, T, Rudan, I, Wright, A,
Wilson, JF, Campbell, H & Gyllensten, U (2012). Sequencing of high-complexity DNA pools for
identification of nucleotide and structural variants in regions associated with complex traits. European
Journal of Human Genetics, 20(1), 77-83.
Erasmus MC – Research Annual Report 2012
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Zerr, I., Kallenberg, K, Summers, DM, Romero, C, Taratuto, A, Heinemann, U, Breithaupt, M, Varges, D,
Meissner, B, Ladogana, A., Schuur, M., Haik, S, Collins, SJ, Jansen, G.H., Stokin, GB, Pimentel, J,
Hewer, E, Collie, D, Smith, P., Roberts, H, Brandel, JP, Duijn, C.M. van, Pocchiari, M., Begue, C, Cras, P.,
Will, R.G. & Sanchez-Juan, P (2012). Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob
disease (vol 132, pg 2659, 2009). Brain, 135, 1335-1335.
Part of book - Abstract
Hafkamp-Groen, E. & Raat, H. (2012). Asthma and health related quality of life in childhood and
adolescence. In C Pereira (Ed.), Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment
(pp. 365-372). Rijeka Croatia: InTech.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-01-64-03 - Clinical epidemiology
Programme (brief description)
This program comprises three parts: clinical epidemiology in collaboration with radiology, biostatistics
and pharmaco-epidemiology. The clinical epidemiology group collaborates with the department of
radiology in a joint research program for the Assessment of Radiological Technology (ART program).
This program¿s research focuses on the assessment of medical imaging technology, especially
diagnostic imaging but also image-guided therapies, with an emphasis on cardiovascular disease.
Methodological research in the ART program focuses on developing the methods for evaluating
diagnostic imaging procedures using stochastic modeling and utility assessment related to diagnostic
testing and therapeutic outcomes. The biostatistics group provides quantitative support for various
studies in the Erasmus MC. For its own research, the biostatistics group focuses on the application of
new developments in statistics, such as new analytic methods for dependent observations, like random
effect models, Baysian methods and sequential analysis. Pharmaco-epidemiologic research focuses on
intended effects of medications, and the effects of medication use under common circumstances in
large populations.\
Key Figures
Department
Sp1
Sp2
epidemiology
2
medical ethics and
filosophy of medicine
3,94
Total
4,26
2
Sp3
Sp4
SpTot
1,55
7,49
0,32
T1
T2
T3
Ttot
IS
FS
OP
Ptot
4
0
0
4
40
5
0
49
0,32
0
1,55
7,81
Thesis
Eijgelsheim, M. (2011, maart 09). Genetic determinants of heart rhythm and conduction disorders. EUR.
Prom./coprom.: Prof. Dr. B.H.C. Stricker & Prof. Dr. A.G. Uitterlinden.
Genders, T.S.S. (2012, juni 29). Diagnostic imaging stragegies for patients with suspected coronary
artery disease. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. K. Nieman.
Grootenboer, N. (2012, november 07). Gender differences in presentation of disease and clinical
outcome after vascular surgery. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. M.R.H.M. van
Sambeek.
Rodenburg, E.M. (2012, september 19). Sex differences in cardiovascular drug response. EUR.
Prom./coprom.: Prof. Dr. B.H.C. Stricker & Prof. Dr. A.G. Uitterlinden.
Ruiter, T.R.. Pharmaco-epidemiology as a tool in pharmacovigilance: studying cancer as adverse drug
reaction. EUR. Prom./coprom.: Prof. Dr. B.H.C. Stricker & Prof. Dr. A.G. Uitterlinden.
Article/Letter to the editor
Amin, N., Schuur, M., Gusareva, ES, Isaacs, A, Aulchenko, Y.S., Kirichenko, AV, Zorkoltseva, IV,
Axenovich, T.I., Oostra, B.A., Janssens, A.C.J.W. & Duijn, C.M. van (2012). A genome-wide linkage
study of individuals with high scores on NEO personality traits. Molecular Psychiatry, 17(10),
1031-1041.
Amin, N., Byrne, E, Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I.M., Vink, J.M., Rawal, R,
Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N,
Doering, A, Isaacs, A, Broer, L., Wray, NR, Montgomery, GW, Levy, D., Psaty, B.M., Gudnason, V,
Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, Rooij,
F.J.A. van, Aulchenko, Y.S., Hottenga, J.J., Rivadeneira, FR, Hofman, A., Uitterlinden, A.G., Hammond,
Erasmus MC – Research Annual Report 2012
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CJ, Shin, SY, Ikram, A., Witteman, J.C.M., Janssens, A.C.J.W., Snieder, H, Tiemeier, H.W.,
Wolfenbuttel, BHR, Oostra, B.A., Heath, AC, Wichmann, E, Spector, T.D., Grabe, HJ, Boomsma, D.I.,
Martin, NG & Duijn, C.M. van (2012). Genome-wide association analysis of coffee drinking suggests
association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17(11), 1116-1129.
Bie, S. de, Verhamme, K.M.C., Straus, S.M.J.M., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2012).
Vaccine-Based Subgroup Analysis in VigiBase Effect on Sensitivity in Paediatric Signal Detection. Drug
Safety, 35(4), 335-346.
Bunnik, E.M., Schermer, M.H.N. & Janssens, A.C.J.W. (2012). The role of disease characteristics in the
ethical debate on personal genome testing. BMC MEDICAL GENOMICS, 5.
Coppus, A.M.W., Schuur, M., Vergeer, J, Janssens, A.C.J.W., Oostra, B.A., Verbeek, MM & Duijn, C.M.
van (2012). Plasma beta amyloid and the risk of Alzheimer's disease in Down syndrome. Neurobiology
of Aging, 33(9), 1988-1994.
Dastani, Z, Hivert, MF, Timpson, N, Perry, JRB, Yuan, X, Scott, RA, Henneman, P., Heid, IM, Kizer, JR,
Lyytikainen, LP, Fuchsberger, C, Tanaka, T, Morris, AP, Small, K., Isaacs, A, Beekman, M, Coassin, S,
Lohman, K, Qi, L., Kanoni, S, Pankow, JS, Uh, HW, Wu, Y., Bidulescu, A, Rasmussen-Torvik, LJ,
Greenwood, CMT, Ladouceur, M, Grimsby, J, Manning, AK, Liu, CT, Kooner, J, Mooser, VE,
Vollenweider, P, Kapur, KA, Chambers, J, Wareham, NJ, Langenberg, C, Frants, R, Willems-vanDijk, K,
Oostra, B.A., Willems, S.M., Lamina, C, Winkler, TW, Psaty, B.M., Tracy, RP, Brody, J, Chen, I, Viikari, J,
Kahonen, M, Pramstaller, P.P., Evans, DM, Pourcain, B St, Sattar, N, Wood, AR, Bandinelli, S, Carlson,
OD, Egan, JM, Bohringer, S, Heemst, D van, Kedenko, L, Kristiansson, K, Nuotio, ML, Loo, BM, Harris, T,
Garcia, M, Kanaya, A, Haun, M, Klopp, N, Wichmann, HE, Deloukas, P, Katsareli, E, Couper, DJ, Duncan,
BB, Kloppenburg, M, Adair, LS, Borja, JB, Wilson, JG, Musani, S, Guo, XQ, Johnson, T, Semple, R,
Teslovich, TM, Allison, MA, Redline, S, Buxbaum, SG, Mohlke, KL, Meulenbelt, I., Ballantyne, C.M.,
Dedoussis, GV, Hu, FB, Liu, YM, Paulweber, B, Spector, T.D., Slagboom, P.E., Ferrucci, L, Jula, A,
Perola, M, Raitakari, O, Florez, JC, Salomaa, V, Eriksson, JG, Frayling, T.M., Hicks, AA, Lehtimaki, T,
Smith, G.D., Siscovick, D.S., Kronenberg, F, Duijn, C.M. van, Loos, RJF, Waterworth, D.M., Meigs, JB,
Dupuis, J & Richards, JB (2012). Novel Loci for Adiponectin Levels and Their Influence on Type 2
Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. PLoS Genetics, 8(3).
Dedic, A., Genders, T.S.S., Hunink, M.G.M. & Nieman, K. (2012). Prognostic Value of Coronary CT
Angiography for Cardiac Events Response. Radiology, 263(3), 934-934.
Demirkan, A., Duijn, C.M. van, Ugocsai, P, Isaacs, A, Pramstaller, P.P., Liebisch, G, Wilson, JF,
Johansson, A, Rudan, I, Aulchenko, Y.S., Kirichenko, AV, Janssens, A.C.J.W., Jansen, RC, Gnewuch, C,
Domingues, FS, Pattaro, C, Wild, SH, Jonasson, I, Polasek, O, Zorkoltseva, IV, Hofman, A., Karssen,
L.C., Struchalin, M, Floyd, J, Igl, W, Biloglav, Z, Broer, L., Pfeufer, A, Pichler, I, Campbell, S, Zaboli, G,
Kolcic, I, Rivadeneira Ramirez, F., Huffman, J, Hastie, ND, Uitterlinden, A.G., Franke, L, Franklin, CS,
Vitart, V, Nelson, CP, Preuss, M, Bis, JC, O'Donnell, CJ, Franceschini, N, Witteman, J.C.M., Axenovich, T,
Oostra, B.A., Meitinger, T, Hicks, AA, Hayward, C, Wright, AF, Gyllensten, U, Campbell, H & Schmitz, G.
(2012). Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and
Sphingolipid Concentrations. PLoS Genetics, 8(2).
Dent, THS, Wright, CF, Stephan, BCM, Brayne, C. & Janssens, A.C.J.W. (2012). Risk Prediction Models:
A Framework for Assessment. Public Health Genomics, 15(2), 98-105.
Diack, AB, Ritchie, D., Bishop, M, Pinion, V, Brandel, J-P, Haik, S, Tagliavini, F, Duijn, C.M. van, Belay,
ED, Gambetti, P, Schonberger, LB, Piccardo, P, Will, R.G. & Manson, JC (2012). Constant transmission
properties of variant Creutzfeldt-Jakob disease in 5 countries. Emerging Infectious Diseases, 18(10),
1574-1579.
Fakhry, F., Luijtgaarden, K.M. van de, Bax, L., Hoed, P.T. den, Hunink, M.G.M., Rouwet, E.V. & Spronk,
S. (2012). Supervised walking therapy in patients with intermittent claudication. Journal of Vascular
Surgery, 56(4), 1132-1142.
Erasmus MC – Research Annual Report 2012
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Ferket, B.S., Grootenboer, N., Colkesen, EB, Visser, J.J., Sambeek, M.R.H.M. van, Spronk, S.,
Steyerberg, E.W. & Hunink, M.G.M. (2012). Systematic review of guidelines on abdominal aortic
aneurysm screening. Journal of Vascular Surgery, 55(5), 1296-1304.
Ferket, B.S., Spronk, S., Colkesen, EB & Hunink, M.G.M. (2012). Systematic Review of Guidelines on
Peripheral Artery Disease Screening. American Journal of Medicine, 125(2), 198-+.
Genders, T.S.S., Steyerberg, E.W., Nieman, K., Galema, T.W., Mollet, N.R., Feyter, P.J. de, Krestin,
G.P., Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J.,
Goetschalckx, K, Cademartiri, F., Maffei, E., Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B,
Fornaro, J, Feuchtner, G, Zordo, T De, Auer, T, Plank, F, Friedrich, G, Pugliese, F., Petersen, SE, Davies,
LC, Schoepf, UJ, Rowe, GW, Mieghem, C.A.G. van, Driessche, L van, Sinitsyn, V, Gopalan, D., Nikolaou,
K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B., Becker, D,
Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E., Laule, M & Hunink, M.G.M. (2012).
Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of
existing cohorts. British Medical Journal, 344.
Heun, R, Kölsch, H, Ibrahim-Verbaas, CA, Combarros, O, Aulchenko, Y.S., Breteler, M.M.B., Schuur, M.,
Duijn, C.M. van, Hammond, N, Belbin, O, Cortina-Borja, M, Wilcock, GK, Brown, K., Barber, R, Kehoe,
PG, Coto, E, Alvarez, V, Lehmann, MG, Deloukas, P, Mateo, I, Morgan, K., Warden, DR, Smith, AD &
Lehmann, DJ (2012). Interactions between PPAR-alpha and inflammation-related cytokine genes on the
development of Alzheimer's disease, observed by the Epitasis Project. International Journal of Molecular
Epidemiology and Genetics, 3(1), 39-47.
Janssens, A.C.J.W., Henneman, L, Detmar, S.B., Khoury, MJ, Steyerberg, E.W., Eijkemans, M.J.C.,
Mushkudiani, N., Oostra, B.A., Duijn, C.M. van & Mackenbach, J.P. (2012). Accuracy of self-reported
family history is strongly influenced by the accuracy of self-reported personal health status of relatives.
Journal of Clinical Epidemiology, 65(1), 82-89.
Janssens, A.C.J.W. & Kraft, P (2012). Research Conducted Using Data Obtained through Online
Communities: Ethical Implications of Methodological Limitations. PLoS Medicine, 9(10).
Jong, M.C. de, Genders, T.S.S., Geuns, R.J.M. van, Moelker, A. & Hunink, M.G.M. (2012). Diagnostic
performance of stress myocardial perfusion imaging for coronary artery disease: a systematic review
and meta-analysis. European Radiology, 22(9), 1881-1895.
Kempen, B.J.H. van, Ferket, B.S., Hofman, A., Spronk, S., Steyerberg, E.W. & Hunink, M.G.M. (2012).
Do Different Methods of Modeling Statin Treatment Effectiveness Influence the Optimal Decision?
Medical Decision Making, 32(3), 507-516.
Kempen, B.J.H. van, Ferket, B.S., Hofman, A., Steyerberg, E.W., Colkesen, EB, Boekholdt, S.M.,
Wareham, NJ, Khaw, KT & Hunink, M.G.M. (2012). Validation of a model to investigate the effects of
modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the Rotterdam ischemic
heart disease and stroke computer simulation (RISC) model. BMC Medicine, 10.
Keyser, C.E. de, Stricker, B.H.C. & Becker, M.L. (2012). Genetic determinants of statin therapy: studies
after the GWA. Pharmacogenomics, 13(1), 15-16.
Kocken, P.L., Schonbeck, Y, Henneman, L, Janssens, A.C.J.W. & Detmar, S.B. (2012). Ethnic
differences and parental beliefs are important for overweight prevention and management in children:
a cross-sectional study in the Netherlands. Bmc Public Health, 12.
Koller, M.T., Leening, M.J.G., Wolbers, M, Steyerberg, E.W., Hunink, M.G.M., Schoop, R, Hofman, A.,
Bucher, HC, Psaty, B.M., Lloyd-Jones, DM & Witteman, J.C.M. (2012). Development and Validation of a
Coronary Risk Prediction Model for Older US and European Persons in the Cardiovascular Health Study
and the Rotterdam Study. Annals of Internal Medicine, 157(6), 389-397.
Erasmus MC – Research Annual Report 2012
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Kundu, S., Karssen, L.C. & Janssens, A.C.J.W. (2012). Analytical and simulation methods for estimating
the potential predictive ability of genetic profiling: a comparison of methods and results. European
Journal of Human Genetics, 20(12), 1270-1274.
Leening, M.J.G., Elias-Smale, S.E., Kavousi, M., Felix, J.F., Deckers, J.W., Vliegenthart, R., Oudkerk,
M.., Hofman, A., Steyerberg, E.W., Stricker, B.H.C. & Witteman, J.C.M. (2012). Coronary Calcification
and the Risk of Heart Failure in the Elderly The Rotterdam Study. JACC-cardiovascular imaging, 5(9),
874-880.
Leening, M.J.G., Kavousi, M., Heeringa, J., Rooij, F.J.A. van, Heemst, J. van, Deckers, J.W., Mattace
Raso, F.U.S., Ziere, G., Hofman, A., Stricker, B.H.C. & Witteman, J.C.M. (2012). Methods of data
collection and definitions of cardiac outcomes in the Rotterdam Study. European Journal of
Epidemiology, 27(3), 173-185.
Luciano, M, Lopez, LM, Moor, MHM de, Harris, SE, Davies, G., Nutile, T, Krueger, RF, Esko, T,
Schlessinger, D, Toshiko, T, Derringer, JL, Realo, A, Hansell, NK, Pergadia, ML, Pesonen, AK, Sanna, S,
Terracciano, A, Madden, PAF, Penninx, B, Spinhoven, P., Hartman, C.A., Oostra, B.A., Janssens,
A.C.J.W., Eriksson, JG, Starr, JM, Cannas, A, Ferrucci, L, Metspalu, A, Wright, MJ, Heath, AC, Duijn,
C.M. van, Bierut, LJ, Raikkonen, K, Martin, NG, Ciullo, M, Rujescu, D, Boomsma, D.I. & Deary, IJ (2012).
Longevity candidate genes and their association with personality traits in the elderly. American Journal
of Medical Genetics Part B-Neuropsychiatric Genetics, 159B(2), 192-200.
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Corticosteroids and Open-Angle Glaucoma in the
Elderly A Population-Based Cohort Study. Drugs & Aging, 29(12), 963-970.
Moor, MHM de, Costa, PT, Terracciano, A, Krueger, RF, Geus, E.J.C. de, Toshiko, T, Penninx, BWJH,
Esko, T, Madden, PAF, Derringer, J, Amin, N., Willemsen, G, Hottenga, J.J., Distel, MA, Uda, M, Sanna,
S, Spinhoven, P., Hartman, C.A., Sullivan, P, Realo, A, Allik, J, Heath, AC, Pergadia, ML, Agrawal, A., Lin,
P, Grucza, R, Nutile, T, Ciullo, M, Rujescu, D, Giegling, I, Konte, B, Widen, E, Cousminer, DL, Eriksson,
JG, Palotie, A, Peltonen, L., Luciano, M, Tenesa, A, Davies, G., Lopez, LM, Hansell, NK, Medland, SE,
Ferrucci, L, Schlessinger, D, Montgomery, GW, Wright, MJ, Aulchenko, Y.S., Janssens, A.C.J.W., Oostra,
B.A., Metspalu, A, Abecasis, GR, Deary, IJ, Raikkonen, K, Bierut, LJ, Martin, NG, Duijn, C.M. van &
Boomsma, D.I. (2012). Meta-analysis of genome-wide association studies for personality. Molecular
Psychiatry, 17(3), 337-349.
Neuteboom, R.F., Janssens, A.C.J.W., Siepman, T.A.M., Hoppenbrouwers, I.A., Ketelslegers, I.A.,
Jafari, N., Steegers, E.A.P., Groot, C.J.M. de & Hintzen, R.Q. (2012). Pregnancy in multiple sclerosis:
clinical and self-report scales. Journal of Neurology, 259(2), 311-317.
Osnabrugge, R.L.J., Head, S.J., Genders, T.S.S., Mieghem, N.M.D.A. van, Jaegere, P.P.T. de, Boon,
R.M.A. van der, Kerkvliet, J.M., Kalesan, B, Bogers, A.J.J.C., Kappetein, A.P. & Hunink, M.G.M. (2012).
Costs of Transcatheter Versus Surgical Aortic Valve Replacement in Intermediate-Risk Patients. Annals
of Thoracic Surgery, 94(6), 1954-1960.
Pencina, MJ, D'Agostino, RB, Pencina, KM, Janssens, A.C.J.W. & Greenland, P. (2012). Interpreting
Incremental Value of Markers Added to Risk Prediction Models. American Journal of Epidemiology,
176(6), 473-481.
Pencina, MJ, D'Agostino, RB, Demler, OV, Janssens, A.C.J.W. & Greenland, P. (2012). Pencina et al.
Respond to "The Incremental Value of New Markers" and "Clinically Relevant Measures? A Note of
Caution". American Journal of Epidemiology, 176(6), 492-494.
Rodenburg, E.M., Eijgelsheim, M., Geleijnse, J.M., Amin, N., Duijn, C.M. van, Hofman, A., Uitterlinden,
A.G., Stricker, B.H.C. & Visser, L.E. (2012). CYP1A2 and coffee intake and the modifying effect of sex,
age, and smoking. American Journal of Clinical Nutrition, 96(1), 182-187.
Erasmus MC – Research Annual Report 2012
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Rodenburg, E.M., Stricker, B.H.C. & Visser, L.E. (2012). Sex differences in cardiovascular drug-induced
adverse reactions causing hospital admissions. British Journal of Clinical Pharmacology, 74(6),
1045-1052.
Ruiter, R. de, Visser, L.E., Rodenburg, E.M., Trifiro, G., Ziere, G. & Stricker, B.H.C. (2012). Adverse
Drug Reaction-Related Hospitalizations in Persons Aged 55 Years and Over: A Population-Based Study
in the Netherlands. Drugs & Aging, 29(3), 225-232.
Ruiter, R. de, Teichert, M., Straus, S.M.J.M., Stricker, B.H.C. & Visser, L.E. (2012). Concomitant Use of
Contraceptives and Potentially Teratogenic Medicinal Products-Results From a Study Using Pharmacy
Dispensing Data in the Netherlands. Reproductive Sciences, 19(9), 987-994.
Ruiter, R. de, Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Lower Risk of Cancer in Patients on
Metformin in Comparison With Those on Sulfonylurea Derivatives Results from a large population-based
follow-up study. Diabetes Care, 35(1), 119-124.
Ruiter, R. de, Visser, L.E., Herk-Sukel, MPP van, Geelhoed-Duijvestijn, PH, Bie, S. de, Straus, S.M.J.M.,
Mol, PGM, Romio, S.A., Herings, R.M.C. & Stricker, B.H.C. (2012). Prescribing of Rosiglitazone and
Pioglitazone Following Safety Signals Analysis of Trends in Dispensing Patterns in the Netherlands from
1998 to 2008. Drug Safety, 35(6), 471-480.
Ruiter, R., Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Risk of cancer in patients on insulin glargine
and other insulin analogues in comparison with those on human insulin: results from a large
population-based follow-up study. Diabetologia, 55, 51-62.
Stel, H.F. van, Busschbach, J.J. van, Hunink, M.G.M. & Buskens, E. (2012). Impact of Secondary
Cardiovascular Events on Health Status. Value in Health, 15(1), 175-182.
Stolk, L., Perry, JRB, Chasman, DI, He, CY, Mangino, M, Sulem, P, Barbalic, M, Broer, L., Byrne, EM,
Ernst, F, Esko, T, Franceschini, N, Gudbjartsson, DF, Hottenga, J.J., Kraft, P, McArdle, PF, Porcu, E,
Shin, SY, Smith, AV, Wingerden, S van, Zhai, G., Zhuang, WV, Albrecht, E, Alizadeh, B.Z., Aspelund, T,
Bandinelli, S, Lauc, LB, Beckmann, J.S., Boban, M, Boerwinkle, E., Broekmans, FJ, Burri, A, Campbell, H,
Chanock, SJ, Chen, C, Cornelis, MC, Corre, T, Coviello, AD, d'Adamo, P, Davies, G., Faire, U de, Geus,
E.J.C. de, Deary, IJ, Dedoussis, GVZ, Deloukas, P, Ebrahim, S, Eiriksdottir, G, Emilsson, V, Eriksson, JG,
Fauser, B.C.J.M., Ferreli, L, Ferrucci, L, Fischer, K., Folsom, A.R., Garcia, ME, Gasparini, P, Gieger, C,
Glazer, N, Grobbee, D.E., Hall, P., Haller, T, Hankinson, SE, Hass, M, Hayward, C, Heath, AC, Hofman,
A., Ingelsson, E, Janssens, A.C.J.W., Johnson, AD, karasik, D., Kardia, SLR, Keyzer, J, Kiel, DP, Kolcic, I,
Kutalik, Z, Lahti, J, Lai, S, Laisk, T, Laven, J.S.E., Lawlor, DA, Liu, JJ, Lopez, LM, Louwers, Y.V.,
Magnusson, PKE, Marongiu, M, Martin, NG, Klaric, IM, Masciullo, C, McKnight, B, Medland, SE, Melzer,
D, Mooser, V, Navarro, P, Newman, AB, Nyholt, DR, Onland-Moret, NC, Palotie, A, Pare, G, Parker, AN,
Pedersen, NL, Peeters, P.H.M., Pistis, G, Plump, AS, Polasek, O, Pop, VJM, Psaty, B.M., Raikkonen, K,
Rehnberg, E, Rotter, JI, Rudan, I, Sala, C, Salumets, A, Scuteri, A, Singleton, A., Smith, JA, Snieder, H,
Soranzo, N, Stacey, SN, Starr, JM, Stathopoulou, MG, Stirrups, K, Stolk, R.P., Styrkarsdottir, U, Sun, YV,
Tenesa, A, Thorand, B, Toniolo, D., Tryggvadottir, L, Tsui, K, Ulivi, S, Dam, RM van, Schouw, Y.T. van
der, Gils, CH van, Nierop, P van, Vink, J.M., Visscher, P.M., Voorhuis, M, Waeber, G, Wallaschofski, H.,
Wichmann, HE, Widen, E, Gent, C.J.M. van, Willemsen, G, Wilson, JF, Wolffenbuttel, B.H.R., Wright, AF,
Yerges-Armstrong, LM, Zemunik, T, Zgaga, L, Zillikens, M.C., Zygmunt, M, Arnold, AM, Boomsma, D.I.,
Buring, JE, Crisponi, L, Demerath, EW, Gudnason, V, Harris, T.B., Hu, FB, Hunter, DJ, Launer, L.J.,
Metspalu, A, Montgomery, GW, Oostra, B.A., Ridker, P.M., Sanna, S, Schlessinger, D, Spector, T.D.,
Stefansson, K, Streeten, EA, Thorsteinsdottir, U, Uda, M, Uitterlinden, A.G., Duijn, C.M. van, Volzke, H,
Murray, A, Murabito, JM, Visser, J.A. & Lunetta, KL (2012). Meta-analyses identify 13 loci associated
with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3),
260-U55.
Erasmus MC – Research Annual Report 2012
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Taal, H.R., Pourcain, B St, Thiering, E, Das, S., Mook-Kanamori, D.O., Warrington, NM, Kaakinen, M,
Kreiner-Moller, E, Bradfield, JP, Freathy, RM, Geller, F, Guxens, M, Cousminer, DL, Kerkhof, M.,
Timpson, NJ, Ikram, M.A., Beilin, LJ, Bonnelykke, K, Buxton, JL, Charoen, P, Chawes, B, Eriksson, J,
Evans, DM, Hofman, A., Kemp, JP, Kim, CE, Klopp, N, Lathi, J, Lye, SJ, McMahon, G, Mentch, F,
Muller-Nurasyid, M, O'Reilly, PF, Prokopenko, I, Rivadeneira Ramirez, F., Steegers, E.A.P., Sunyer, J.,
Tiesler, C, Yaghootkar, H, Breteler, M.M.B., DeCarli, C., Debette, S, Fornage, M, Gudnason, V, Launer,
L.J., Lugt, A. van der, Mosley, TH, Seshadri, S, Smith, AV, Vernooij, M.W., Blakemore, AIF, Chiavacci,
RM, Feenstra, B, Fernandez-Banet, J, Grant, S.F.A., Hartikainen, AL, Heijden, A.J. van der, Iniguez, C,
Lathrop, M, McArdle, WL, Molgaard, A, Newnham, JP, Palmer, LJ, Palotie, A, Pouta, A, Ring, SM, Sovio,
U, Standl, M, Uitterlinden, A.G., Wichmann, HE, Vissing, NH, Duijn, C.M. van, McCarthy, MI,
Koppelman, G.H., Estivill, X, Hattersley, A.T., Melbye, M, Bisgaard, H, Pennell, CE, Widen, E,
Hakonarson, H, Smith, G.D., Heinrich, J., Jarvelin, MR & Jaddoe, V.W.V.K. (2012). Common variants at
12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44(5), 532-538.
Taal, H.R., Verwoert, G.C., Demirkan, A., Janssens, A.C.J.W., Rice, K, Ehret, G, Smith, AV, Verhaaren,
B.F.J., Witteman, J.C.M., Hofman, A., Vernooij, M.W., Uitterlinden, A.G., Rivadeneira, F., Ikram, M.A.,
Levy, D., Heijden, A.J. van der, Jaddoe, V.W.V.K. & Duijn, C.M. van (2012). Genome-Wide Profiling of
Blood Pressure in Adults and Children. Hypertension, 59(2), 241-247.
Visser, J.J., Sambeek, M.R.H.M. van, Hunink, M.G.M., Redekop, W.K., Dijk, L.C. van, Hendriks, J.M. &
Bosch, J.L. (2020). Cost analysis of endovascular repari and open surgery in patients with acute
abdominal aortic aneurysms with one-year-follow-up. Radiology, 240, 681-689.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-01-66-01 – Biostatistics
Programme (brief description)
This program comprises two parts: general medical statistics and genetic statistics. The activities
of the general medical statistics group are research in biostatistics on topics such as statistical
modeling of complex data structures, clinical trial methodology, Bayesian methods,
meta-analyses, smoothing approaches, survival analysis, etc. Monthly seminars, working groups
on specific methodological topics, two courses/year and a yearly symposium are activities of the
group to promote statistical research together with quantitative researchers from the whole of
Erasmus MC, but also to make publicity for the department outside Erasmus University. Further,
the group provides statistical consultancy to and collaborates with various clinical departments
and the department of epidemiology. There is also a strong participation of the group in the
Nihes and Erasmus Winter and Summer teaching programs.
In addition, the activities on genetic statistics concentrate on high-throughput methods:
microarrays, SNPs, proteomics and metabolomics. Of special interest is also the cooperation with
the Bioinformatics Department, to integrate data bases, friendly interfaces and standard tools for
data visualization with existing and newly developed statistical methods.
Key Figures
Department
Sp1
biostatistics
4,17
Total
4,17
Sp2
0
Sp3
0
Sp4
SpTot
1,2
5,37
1,2
5,37
T1
T2
T3
Ttot
IS
FS
OP
Ptot
1
0
0
1
85
10
0
96
Thesis
Molas, M.A. (2012, november 20). Complex Data Modelling Using Likelihood and H-Likelihood Methods.
EUR. Prom./coprom.: Prof. Dr. E.M.E.H. Lesaffre.
Article/Letter to the editor
Agbaje, JO, Lesaffre, E. & Declerck, D (2012). Assessment of caries experience in epidemiological
surveys: a review. Community Dental Health, 29(1), 14-20.
Agbaje, JO, Mutsvari, T, Lesaffre, E. & Declerck, D (2012). Examiner performance in calibration
exercises compared with field conditions when scoring caries experience. Clinical Oral Investigations,
16(2), 481-488.
Agbaje, JO, Mutsvari, T, Lesaffre, E. & Declerck, D (2012). Measurement, analysis and interpretation of
examiner reliability in caries experience surveys: some methodological thoughts. Clinical Oral
Investigations, 16(1), 117-127.
Allard, SD, Keersmaecker, B De, Goede, A.L. de, Verschuren, E.J., Koetsveld, J., Reedijk, M.L., Wylock,
C, Bel, AV De, Vandeloo, J, Pistoor, F.H.M., Heirman, C., Beyer, W.E.P., Eilers, P.H.C., Corthals, J.,
Padmos, I., Thielemans, K., Osterhaus, A.D.M.E., Lacor, P, Ende, M.E. van der, Aerts, JL, Baalen, C.A.
van & Gruters, R.A. (2012). A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev
and Nef expressing dendritic cells followed by treatment interruption. Clinical Immunology, 142(3),
252-268.
Andrinopoulou, E.R., Rizopoulos, D., Jin, RY, Bogers, A.J.J.C., Lesaffre, E.M.E.H. & Takkenberg, J.J.M.
(2012). An Introduction to Mixed Models and Joint Modeling: Analysis of Valve Function Over Time.
Annals of Thoracic Surgery, 93(6), 1765-1772.
Bakker, E.M., Meijden, J.C. van der, Nieuwhof, EM, Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Determining presence of lung disease in young children with cystic fibrosis: Lung clearance index,
oxygen saturation and cough frequency. Journal of Cystic Fibrosis, 11(3), 223-230.
Erasmus MC – Research Annual Report 2012
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Bales, D., Beek, N. van der, Smits, M., Willemsen, S.P., Busschbach, J.J. van, Verheul, R. & Andrea, H.
(2012). TREATMENT OUTCOME OF 18-MONTH, DAY HOSPITAL MENTALIZATION-BASED TREATMENT
(MBT) IN PATIENTS WITH SEVERE BORDERLINE PERSONALITY DISORDER IN THE NETHERLANDS.
Journal of Personality Disorders, 26(4), 568-582.
Beek, N.A.M.E. van der, Vries, J.M. de, Hagemans, M.L.C., Hop, W.C.J., Kroos, M.A., Wokke, J.H.J.,
Visser, M de, Engelen, B.G.M. van, Kuks, JBM, Kooi, A.J. van der, Notermans, N.C., Faber, K.G.,
Verschuuren, J.J.G.M., Reuser, A.J.J., Ploeg, A.T. van der & Doorn, P.A. van (2012). Clinical features
and predictors for disease natural progression in adults with Pompe disease: a nationwide prospective
observational study. Orphanet Journal of Rare Diseases, 7, 88.
Bekker- Grob, E.W. de, Kok, I.M.C.M. de, Bulten, J, Rosmalen, J.M. van, Vedder, JEM, Arbyn, M.,
Klinkhamer, P.J.J.M., Siebers, AG & Ballegooijen, M. van (2012). Liquid-based cervical cytology using
ThinPrep technology: weighing the pros and cons in a cost-effectiveness analysis. Cancer Causes &
Control, 23(8), 1323-1331.
Berge, M. van den, Hop, W.C.J., Molen, T. van der, Noord, J.A., Creemers, JPHM, Schreurs, A.J.M.,
Wouters, E.F.M. & Postma, D.S. (2012). Prediction and course of symptoms and lung function around
an exacerbation in chronic obstructive pulmonary disease. Respiratory Research, 13.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P. & Wouden, J.C. v.d. (2012). SIT: efficacy depends on product, not on route of
application Reply. Pediatric Allergy and Immunology, 23(4), 401-402.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P.J.E. & Wouden, J.C. van der (2012). Sublinguale immunotherapie bij kinderen met
allergische rinitis in de huisartsenpraktijk. Nederlands Tijdschrift voor Geneeskunde, 156.
Calvache, JA, Delgado-Noguera, MF, Lesaffre, E.M.E.H. & Stolker, R.J. (2012). Anaesthesia for
evacuation of incomplete miscarriage. Cochrane Database Systematics Review.
Cecere, S, Leroy, R, Groenen, P.J.F., Lesaffre, E. & Declerck, D (2012). Estimating emergence
sequences of permanent teeth in Flemish schoolchildren using interval-censored biplots: a graphical
display of tooth emergence sequences. Community Dentistry and Oral Epidemiology, 40(suppl.1),
50-56.
Declerck, D, Lesaffre, E., Kargul, B & Bekiroglu, N (2012). Special Issue: 4th International Meeting:
Methodological Issues in Oral Health Research - Intervention Studies Preface. Community Dentistry and
Oral Epidemiology, 40, 1-2.
Diya, L, Heede, K, Sermeus, W. & Lesaffre, E. (2012). The relationship between in-hospital mortality,
readmission into the intensive care nursing unit and/or operating theatre and nurse staffing levels.
Journal of Advanced Nursing, 68(5), 1073-1081.
Eijk, A.C. van der, Horsch, S., Eilers, P.H.C., Dankelman, J & Smit, B.J. (2012). "New-Generation" Pulse
Oximeters in Extremely Low-Birth-Weight Infants How Do They Perform in Clinical Practice? Journal of
Perinatal & Neonatal Nursing, 26(2), 172-180.
Eilers, P.H.C., Roder, E., Savelkoul, H.F.J. & Gerth van Wijk, R. (2012). Quantile regression for the
statistical analysis of immunological data with many non-detects. BMC Immunology, 13.
Euser, A.S., Arends, L.R., Evans, B.E., Greaves-Lord, K., Huizink, A.C. & Franken, I.H.A. (2012). The
P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: A
meta-analytic investigation. Neuroscience and Biobehavioral Reviews, 36(1), 572-603.
Gabriele, C., Silva, L.M., Arends, L.R., Raat, H., Moll, H.A., Hofman, A., Jaddoe, V.W.V.K. & Jongste, J.C.
de (2012). Early respiratory morbidity in a multicultural birth cohort: the Generation R Study. European
Journal of Epidemiology, 27(6), 453-462.
Erasmus MC – Research Annual Report 2012
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Gabriele, C., Jaddoe, V.W.V.K., Mastrigt, E. van, Arends, L.R., Hofman, A., Moll, H.A. & Jongste, J.C. de
(2012). Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study. European
Respiratory Journal, 39(3), 567-572.
Gabriele, C., Jaddoe, V.W.V.K., Mastrigt, E. van, Arends, L.R., Hofman, A., Moll, H.A. & Jongste, J.C. de
(2012). Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study (vol 39, pg 567,
2012). European Respiratory Journal, 39(5), 1281-1281.
Garcia-Zattera, MJ, Jara, A, Lesaffre, E. & Marshall, G (2012). Modeling of Multivariate Monotone
Disease Processes in the Presence of Misclassification. Journal of the American Statistical Association,
107(499), 976-989.
Genders, T.S.S., Spronk, S., Stijnen, T., Steyerberg, E.W., Lesaffre, E.M.E.H. & Hunink, M.G.M. (2012).
Methods for Calculating Sensitivity and Specificity of Clustered Data: A Tutorial. Radiology, 265(3),
910-916.
Giessen, L.J. van der, Bakker, E.M., Joosten, K.F.M., Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Nocturnal oxygen saturation in children with stable cystic fibrosis. Pediatric Pulmonology, 47,
1123-1130.
Gravendeel, L.A.M., Rooi, J.J. de, Eilers, P.H.C., Bent, M.J. van den, Sillevis Smitt, P.A.E. & French, P.J.
(2012). Gene expression profiles of gliomas in formalin-fixed paraffin-embedded material. British
Journal of Cancer, 106(3), 538-545.
Harlaar, J.J., Gosselink, M.P., Hop, W.C.J., Lange, J.F., Busch, O.R.C. & Jeekel, J. (2012). Blood
Transfusions and Prognosis in Colorectal Cancer Long-Term Results of a Randomized Controlled Trial.
Annals of Surgery, 256(5), 681-687.
Helder, O.K., Goudoever, J.B. van, Hop, W.C.J., Brug, J. & Kornelisse, R.F. (2012). Hand disinfection in
a neonatal intensive care unit: continuous electronic monitoring over a one-year period. Bmc Infectious
Diseases, 12.
Hermans, J.J., Wentink, N., Beumer, A., Hop, W.C.J., Heijboer, M.P., Moonen, AFCM & Ginai, A.Z.
(2012). Correlation between radiological assessment of acute ankle fractures and syndesmotic injury on
MRI. Skeletal Radiology, 41(7), 787-801.
Hermans, J.J., Beumer, A., Hop, W.C.J., Moonen, AFCM & Ginai, A.Z. (2012). Tibiofibular syndesmosis
in acute ankle fractures: additional value of an oblique MR image plane. Skeletal Radiology, 41(2),
193-202.
Hoevenaars, N.E.D., Gans, D, Missotten, T, Rooij, J. van, Lesaffre, E. & Meurs, J.C. van (2012).
Suspected Bacterial Endophthalmitis following Intravitreal Anti-VEGF Injection: Case Series and
Literature Review. Ophthalmologica, 228(3), 143-147.
Hooven, E.H. van den, Pierik, F.H., Kluizenaar, Y. de, Willemsen, S.P., Hofman, A., Ratingen, SW van,
Zandveld, PYJ, Mackenbach, J.P., Steegers, E.A.P., Miedema, HME & Jaddoe, V.W.V.K. (2012). Air
Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth
Outcomes: A Prospective Cohort Study. Environmental Health Perspectives, 120(1), 150-156.
Hurtado, PX, Schnabel, SK, Zaban, A, Vetelainen, M, Virtanen, E, Eilers, P.H.C., Eeuwijk, FA van, Visser,
RGF & Maliepaard, C (2012). Dynamics of senescence-related QTLs in potato. Euphytica, 183(3),
289-302.
Kerver, A.L.A., Ham, A.C., Theeuwes, H.P., Eilers, P.H.C., Poublon, A.R., Kerver, A.J.H. & Kleinrensink,
G.J. (2012). The surgical anatomy of the small saphenous vein and adjacent nerves in relation to
endovenous thermal ablation. Journal of Vascular Surgery, 56(1), 181-188.
Erasmus MC – Research Annual Report 2012
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Kok, I.M.C.M. de, Rosmalen, J.M. van, Dillner, J., Arbyn, M., Sasieni, P., Iftner, T. & Ballegooijen, M. van
(2012). Primary screening for human papillomavirus compared with cytology screening for cervical
cancer in European settings: cost effectiveness analysis based on a Dutch microsimulation model.
British Medical Journal, 344.
Lem, A.J., Kaay, D.C.M. van der, Ridder, M.A.J. de, Waarde, WM Bakker-van, Hulst, FJPCM van der,
Mulder, J.C., Noordam, C., Odink, RJ, Oostdijk, W., Schroor, E.J., Sulkers, E.J., Westerlaken, C. &
Hokken-Koelega, A.C.S. (2012). Adult Height in Short Children Born SGA Treated with Growth Hormone
and Gonadotropin Releasing Hormone Analog: Results of a Randomized, Dose-Response GH Trial.
Journal of Clinical Endocrinology and Metabolism, 97(11), 4096-4105.
Lem, A.J., Jobse, I., Kaay, D.C.M. van der, Ridder, M.A.J. de, Raat, H. & Hokken-Koelega, A.C.S. (2012).
Health-Related Quality of Life in Short Children Born Small for Gestational Age: Effects of Growth
Hormone Treatment and Postponement of Puberty. Hormone Research in Paediatrics, 77(3).
Lem, A.J., Rijke, Y.B. de, Toor, H. van, Ridder, M.A.J. de, Visser, T.J. & Hokken-Koelega, A.C.S. (2012).
Serum Thyroid Hormone Levels in Healthy Children from Birth to Adulthood and in Short Children Born
Small for Gestational Age. Journal of Clinical Endocrinology and Metabolism, 97(9), 3170-3178.
Lesaffre, E. & Gerds, T (2012). Special Issue: Papers from the 31st Annual Conference of the
International Society for Clinical Biostatistics 20-30 May 2012 Preface. Statistics in Medicine, 31(11-12),
1001-1001.
Lesaffre, E.M.E.H. (2012). Longitudinal studies in rheumatology: Some guidance for analysis. Bulletin of
the NYU Hospital for Joint Diseases, 70(2), 65-72.
Loeve, M., Hop, W.C.J., Bruijne, M. de, Hal, P.T.W. van, Robinson, P., Aitken, ML, Dodd, J.D. & Tiddens,
H.A.W.M. (2012). Chest Computed Tomography Scores Are Predictive of Survival in Patients with Cystic
Fibrosis Awaiting Lung Transplantation. American Journal of Respiratory and Critical Care Medicine,
185(10), 1096-1103.
Loeve, M., Bruijne, M. de, Hartmann, I.J.C., Straten, M. van, Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Three-Section Expiratory CT: Insufficient for Trapped Air Assessment in Patients with Cystic Fibrosis?
Radiology, 262(3), 969-976.
Menendez, P, Eilers, P.H.C., Tikunov, Y, Bovy, A & Eeuwijk, F van (2012). Penalized regression
techniques for modeling relationships between metabolites and tomato taste attributes. Euphytica,
183(3), 379-387.
Menten, J., Boelaert, M & Lesaffre, E. (2012). An application of Bayesian growth mixture modelling to
estimate infection incidences from repeated serological tests. Statistical Modelling, 12(6), 551-578.
Mokhles, M.M., Rizopoulos, D., Andrinopoulou, E.R., Bekkers, J.A., Roos-Hesselink, J.W., Lesaffre,
E.M.E.H., Bogers, A.J.J.C. & Takkenberg, J.J.M. (2012). Autograft and pulmonary allograft performance
in the second post-operative decade after the Ross procedure: insights from the Rotterdam Prospective
Cohort Study. European Heart Journal, 33(17), 2213-2224.
Mook-Kanamori, D.O., Beijsterveldt, C.E.M. van, Steegers, E.A.P., Aulchenko, Y.S., Raat, H., Hofman,
A., Eilers, P.H.C., Boomsma, D.I. & Jaddoe, V.W.V.K. (2012). Heritability Estimates of Body Size in Fetal
Life and Early Childhood. PLoS One, 7(7).
Mutsvari, T, Garcia-Zattera, MJ, Declerck, D & Lesaffre, E. (2012). Dealing with misclassification and
missing data when estimating prevalence and incidence of caries experience. Community Dentistry and
Oral Epidemiology, 40, 28-35.
Nistelrooij, A.M.J. van, Andrinopoulou, E.R., Lanschot, J.J.B. van, Tilanus, H.W. & Wijnhoven, B.P.L.
(2012). Influence of young age on outcome after esophagectomy for cancer. World Journal of Surgery,
36(11), 2612-2621.
Erasmus MC – Research Annual Report 2012
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Niwinska, A & Murawska, M. (2012). NEW BREAST CANCER RECURSIVE PARTITIONING ANALYSIS
PROGNOSTIC INDEX IN PATIENTS WITH NEWLY DIAGNOSED BRAIN METASTASES. International
Journal of Radiation Oncology Biology Physics, 82(5), 2065-2071.
Nout, E., Bezooijen, J.S. van, Koudstaal, M.J., Veenland, J.F., Hop, W.C.J., Wolvius, E.B. & Wal, K.G.H.
van der (2012). Orbital change following Le Fort III advancement in syndromic craniosynostosis:
Quantitative evaluation of orbital volume, infra-orbital rim and globe position. Journal of
Cranio-Maxillofacial Surgery, 40(3), 223-228.
Obermann-Borst, S.A., Heijmans, B.T., Eilers, P.H.C., Tobi, EW, Steegers, E.A.P., Slagboom, P.E. &
Steegers-Theunissen, R.P.M. (2012). Periconception maternal smoking and low education are
associated with methylation of INSIGF in children at the age of 17 months. Journal of Developmental
Origins of Health and Disease, 3(5), 315-320.
Oirbeek, R. van & Lesaffre, E. (2012). Assessing the predictive ability of a multilevel binary regression
model. Computer Statistics & Data Analysis, 56(6), 1966-1980.
Olieman, J.F., Penning, C., Poley, M.J., Utens, E.M.W.J., Hop, W.C.J. & Tibboel, D. (2012). Impact of
infantile short bowel syndrome on long-term health-related quality of life: a cross-sectional study.
Journal of Pediatric Surgery, 47(7), 1309-1316.
Oudijk, L., Bakker, M.A. den, Hop, W.C.J., Cohen, M., Charles, AK, Alaggio, R, Coffin, CM & Krijger, R.R.
de (2012). Solitary, multifocal and generalized myofibromas: clinicopathological and
immunohistochemical features of 114 cases. Histopathology, 60(6B), E1-E11.
Prick, B.W., Hop, W.C.J. & Duvekot, J.J. (2012). Maternal phenylketonuria and hyperphenylalaninemia
in pregnancy: pregnancy complications and neonatal sequelae in untreated and treated pregnancies.
American Journal of Clinical Nutrition, 95(2), 374-382.
Prytula, A.A., Bouts, AH, Mathot, R.A.A., Gelder, T. van, Croes, LK, Hop, W.C.J. & Cransberg, K. (2012).
Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal
transplant recipients. Pediatric Transplantation, 16(6), 613-618.
Quax, R.A.M., Man, Y.A. de, Koper, F.J.W., Rossum, E.F.C. van, Willemsen, S.P., Lamberts, S.W.J.,
Hazes, J.M.W., Dolhain, R.J.E.M. & Feelders, R.A. (2012). Glucocorticoid receptor gene polymorphisms
and disease activity during pregnancy and the postpartum period in rheumatoid arthritis. Arthritis
Research & Therapy, 14(4).
Ramlal, SK, Visser, FJ, Hop, W.C.J., Staffhorst, B.J.F.A., Dekhuijzen, P.N.R. & Heijdra, YF (2012). The
relationship between inspiratory lung function parameters and airway hyper-responsiveness in subjects
with mild to moderate COPD. BMC Research Notes, 5, 209.
Ramshorst, G.H. van, Eker, H.H., Hop, W.C.J., Jeekel, J. & Lange, J.F. (2012). Impact of incisional
hernia on health-related quality of life and body image: a prospective cohort study. American Journal of
Surgery, 204(2), 144-150.
Rebolj, M., Helmerhorst, T.J.M., Habbema, D, Looman, C.W.N., Boer, R., Rosmalen, J.M. van &
Ballegooijen, M. van (2012). Risk of cervical cancer after completed post-treatment follow-up of cervical
intraepithelial neoplasia: population based cohort study. British Medical Journal, 345.
Renes, J.S., Ridder, M.A.J. de, Breukhoven, P.E., Lem, A.J. & Hokken-Koelega, A.C.S. (2012).
Methylphenidate and the Response to Growth Hormone Treatment in Short Children Born Small for
Gestational Age. PLoS One, 7(12).
Ribeiro, AFT, Pratcorona, M., Erpelinck-Verschueren, C, Rockova, V., Sanders, M.A., Abbas, S.,
Figueroa, ME, Zeilemaker, A., Melnick, A, Lowenberg, B., Valk, P.J.M. & Delwel, H.R. (2012). Mutant
DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood, 119(24), 5824-5831.
Erasmus MC – Research Annual Report 2012
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Rijlaarsdam, J., Stevens, G.W.J.M., Ende, J. van der, Arends, L.R., Hofman, A., Jaddoe, V.W.V.K.,
Mackenbach, J.P., Verhulst, F.C. & Tiemeier, H.W. (2012). A brief observational instrument for the
assessment of infant home environment: development and psychometric testing. International Journal
of Methods in Psychiatric Research, 21(3), 195-204.
Rikhtehgaran, R, Kazemi, I, Verbeke, G., Kort, W de & Lesaffre, E. (2012). Piecewise transition models
with random effects for unequally spaced longitudinal measurements. Statistical Modelling, 12(6),
503-525.
Rippe, R.C.A., Meulman, J.J. & Eilers, P.H.C. (2012). Correction of fluorescence bias on Affymetrix
genotyping microarrays. Journal of Chemometrics, 26(5), 191-196.
Rippe, R.C.A., Meulman, J.J. & Eilers, P.H.C. (2012). Reliable Single Chip Genotyping with
Semi-Parametric Log-Concave Mixtures. PLoS One, 7(10).
Rippe, R.C.A., Meulman, J.J. & Eilers, P.H.C. (2012). Visualization of Genomic Changes by Segmented
Smoothing Using an L-0 Penalty. PLoS One, 7(6).
Rizopoulos, D. (2012). Fast fitting of joint models for longitudinal and event time data using a
pseudo-adaptive Gaussian quadrature rule. Computer Statistics & Data Analysis, 56(3), 491-501.
Rockova, V., Lesaffre, E., Luime, J.J. & Lowenberg, B. (2012). Hierarchical Bayesian formulations for
selecting variables in regression models. Statistics in Medicine, 31(11-12), 1221-1237.
Rosmalen, J van, Kok, I.M.C.M. de & Ballegooijen, M. van (2012). Cost-effectiveness of cervical cancer
screening: cytology versus human papillomavirus DNA testing. Bjog-An International Journal of
Obstetrics and Gynaecology, 119(6), 699-709.
Runia, T.F., Hop, W.C.J., Rijke, Y.B. de, Buljevac, D. & Hintzen, R.Q. (2012). Lower serum vitamin D
levels are associated with a higher relapse risk in multiple sclerosis. Neurology, 79(3), 261-266.
Sant, H.P. van t, Slieker, J.C., Hop, W.C.J., Weidema, W.F., Lange, J.F., Vermeulen, J. & Contant, CME
(2012). The influence of mechanical bowel preparation in elective colorectal surgery for diverticulitis.
Techniques in Coloproctology, 16(4), 309-314.
Schaible, T., Busing, KA, Felix, J.F., Hop, W.C.J., Zahn, K, Wessel, L., Siemer, J, Neff, KW, Tibboel, D.,
Reiss, I.K.M. & Hout, L. van den (2012). Prediction of chronic lung disease, survival and need for ECMO
therapy in infants with congenital diaphragmatic hernia: Additional value of fetal MRI measurements?
European Journal of Radiology, 81(5), 1076-1082.
Schoonderwaldt, E.M., Groenenberg, I.A.L., Hop, W.C.J., Wladimiroff, J.W. & Steegers, E.A.P. (2012).
Reproducibility of echocardiographic measurements of human fetal left ventricular volumes and
ejection fractions using four-dimensional ultrasound with the spatio-temporal image correlation
modality. European Journal of Obstetrics, Gynecology and Reproductive Biology, 160 (1), 22-29.
Slieker, J.C., Komen, N, Mannaerts, GH, Karsten, T.M., Willemsen, P, Murawska, M., Jeekel, J. & Lange,
J.F. (2012). Long-term and Perioperative Corticosteroids in Anastomotic Leakage A Prospective Study of
259 Left-Sided Colorectal Anastomoses. Archives of Surgery, 147(5), 447-452.
Smalberg, J.H., Arends, L.R., Valla, DC, Kiladjian, JJ, Janssen, H.L.A. & Leebeek, F.W.G. (2012).
Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis.
Blood, 120(25), 4921-4928.
Snijder, C.A., Cornette, J.M.J., Hop, W.C.J., Kruip, M.J.H.A. & Duvekot, J.J. (2012). Thrombophylaxis
and bleeding complications after cesarean section. Acta Obstetricia et Gynecologica Scandinavica,
91(5), 560-565.
Erasmus MC – Research Annual Report 2012
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Spoel, M., Laas, R, Gischler, S., Hop, WJC, Tibboel, D., Jongste, J.C. de & IJsselstijn, H. (2012).
Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation. European
Respiratory Journal, 40(6), 1531-1537.
Spoel, M., Hout, L. van den, Gischler, S., Hop, W.C.J., Reiss, I.K.M., Tibboel, D., Jongste, J.C. de &
IJsselstijn, H. (2012). Prospective longitudinal evaluation of lung function during the first year of life
after repair of congenital diaphragmatic hernia. Pediatric Critical Care Medicine, 13(3), E133-E139.
Spoel, M., Meeussen, C.J.H.M., Gischler, S., Hop, W.C.J., Bax, N.M.A., Wijnen, R.M.H., Tibboel, D.,
Jongste, J.C. de & IJsselstijn, H. (2012). Respiratory morbidity and growth after open thoracotomy of
thorascopic repair of esophageal atresia. Journal of Pediatric Surgery, 47, 1975-1983.
Struchalin, M.V., Amin, N., Eilers, P.H.C., Duijn, C.M. van & Aulchenko, Y.S. (2012). An R package
"VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance
heterogeneity. Bmc Genetics, 13.
Struijs, A.E.C.J.M., Sloots, C.E.J., Hop, W.C.J., Tibboel, D. & Wijnen, R.M.H. (2012). The timing of
ostomy closure in infants with necrotizing enterocolitis: a systematic review. Pediatric Surgery
International, 28(7), 667-672.
Valk, R.J.P. van der, Duijts, L., Kerkhof, M., Willemsen, S.P., Hofman, A., Moll, H.A., Smit, H.A.,
Brunekreef, B., Postma, D.S., Jaddoe, V.W.V.K., Koppelman, G.H. & Jongste, J.C. de (2012).
Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of
childhood asthma-like symptoms. Allergy, 67(6), 767-774.
Vanbelle, S, Mutsvari, T, Declerck, D & Lesaffre, E. (2012). Hierarchical modeling of agreement.
Statistics in Medicine, 31(28), 3667-3680.
Verhoeven, J.J., Koenraads, M., Hop, W.C.J., Brand, JB, Polder, MMV de & Joosten, K.F.M. (2012).
Baseline insulin/glucose ratio as a marker for the clinical course of hyperglycemic critically ill children
treated with insulin. Nutrition, 28(1), 25-29.
Verwoert, G.C., Elias-Smale, S.E., Rizopoulos, D., Koller, M.T., Steyerberg, E.W., Hofman, A., Kavousi,
M., Sijbrands, E.J.G., Hoeks, A.P.G., Reneman, R.S., Mattace Raso, F.U.S. & Witteman, J.C.M. (2012).
Does aortic stiffness improve the prediction of coronary heart disease in elderly? The Rotterdam Study.
Journal of Human Hypertension, 26(1), 28-34.
Voort, A.M.M. van der, Jaddoe, V.W.V.K., Valk, R.J.P. van der, Willemsen, S.P., Hofman, A., Moll, H.A.,
Jongste, J.C. de & Duijts, L. (2012). Duration and exclusiveness of breastfeeding and childhood
asthma-related symptoms. European Respiratory Journal, 39, 81-89.
Vries, J.M. de, Beek, N.A.M.E. van der, Hop, W.C.J., Karstens, F.P.J., Wokke, J.H.J., Visser, M de,
Engelen, B.G.M. van, Kuks, JBM, Kooi, A.J. van der, Notermans, N.C., Faber, C.G., Verschuuren,
J.J.G.M., Kruijshaar, M.E., Reuser, A.J.J., Doorn, P.A. van & Ploeg, A.T. van der (2012). Effect of
enzyme therapy and prognostic factors in 69 adults with Pompe disaese: an open-label single-center
study. Orphanet Journal of Rare Diseases, 7, 73.
Weiland, A., Kraats, R.E. van de, Blankenstein, AH, Saase, J.L.C.M. van, Molen, H.T. van der, Bramer,
W.M., Dulmen, A.M. & Arends, L.R. (2012). Encounters between medical specialists and patients with
medically unexplained physical symptoms; influences of communication on patient outcomes and use
of health care: a literature overview. Perspectives on Medical Education, 1(4), 192-206.
Wit, L. de, Putman, K, Devos, H, Brinkmann, N, Dejaeger, E, Weerdt, W De, Jenni, W, Lincoln, N,
Schuback, B, Schupp, W & Lesaffre, E. (2012). FIVE-YEAR MORTALITY AND RELATED PROGNOSTIC
FACTORS AFTER INPATIENT STROKE REHABILITATION: A EUROPEAN MULTI-CENTRE STUDY. Journal
of Rehabilitation Medicine, 44(7), 547-552.
Erasmus MC – Research Annual Report 2012
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Zee, J.A. van der, Eijck, C.H.J. van, Hop, W.C.J., Dekken, H. van, Dicheva, B.M., Seynhaeve, A.L.B.,
Koning, G.A., Eggermont, A.M.M. & Hagen, T.L.M. ten (2012). Expression and prognostic significance of
thymidylate synthase (TS) in pancreatic head and periampullary cancer. European Journal of Surgical
Oncology, 38(11), 1058-1064.
Zee, J.A. van der, Eijck, C.H.J. van, Hop, W.C.J., Biermann, K., Dicheva, B.M., Seynhaeve, A.L.B.,
Koning, G.A., Eggermont, A.M.M. & Hagen, T.L.M. ten (2012). Tumour basement membrane laminin
expression predicts outcome following curative resection of pancreatic head cancer. British Journal of
Cancer, 107(7), 1153-1158.
Book Editorship
Lesaffre, E.M.E.H. & Lawson, A. (Eds.). (2012). Bayesian biostatistics. Chichester: Wiley.
Rizopoulos, D. (Ed.). (2012). Joint Models for Longitudinal and Time-to-Event Data, with Applications in
R Boca Raton. --: CRC.
Boekbespreking
Teuben, S.A.M.C. (2012). dfasd fadklj boek [Bespreking van de boeken
Erasmus MC – Research Annual Report 2012
AAA DG EW & AAAAA]. .
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EMC NIHES-02-65-01 - Effects of screening and clinical interventions on population health
Programme (brief description)
The research programme aims to contribute to improved population health by evaluating the
favourable and unfavourable effects and the cost-effectiveness of health care interventions,
particularly screening for diseases and clinical interventions, and tropical disease control.
Our commitment to the improvement of population health is combined with a strong emphasis on
quantitative research methods, thereby maximising quality and public health impact. We conduct
observational as well as experimental studies amongst other large scale RCT¿s on screening and
often use advanced statistical methods and computer simulation models on the natural history of
disease. A shared research focus includes development and application of dynamic
age-structured population health models; standardization of research methodology with respect
to descriptive health status measurement, development and application of statistical methods
and use and optimization of micro-simulation modelling.
This programme consists of 3 sections: evaluation of screening, medical decision-making, and
infectious diseases control (Prof.dr. H.J. de Koning, Prof.dr. E.W. Steyerberg, Prof.dr. JH
Richardus, Prof. dr. A. van der Heide, Dr. M. van Ballegooijen) and links with the research group
on cancer surveillance (Prof. dr. J.W.W. Coebergh).
In evaluation of screening, three types of study are undertaken:
(1) Monitoring and evaluation of ongoing screening programmes and randomised trials. (2)
Prospective evaluation and prediction of screening strategies, with emphasis on impact on
morbidity and mortality and on cost-effectiveness.
(3) Mathematical modelling of new developments and research questions. Specific fields
are cancer, cardiovascular disease, prenatal screening and child health surveillance,
developmental disorders and child abuse, and genetic disorders.
In evaluation of clinical care, three questions are studied: what is wrong with the patients?
(diagnostics), what can be done about it? (therapy choice), and what will happen? (prognosis).
Emphasis is on studying prognosis and on methodological issues, and on medical decisions
concerning the end of life.
In infectious disease control, research is focused on collection and analysis of empirical data, and
development and application of models for the epidemiology and control of important infectious
diseases of the tropical zone (onchocerciasis, lymphatic filariasis, schistosomiasis, leprosy,
tuberculosis, malaria and sexually transmitted diseases), and in the Western context like
Hepatitis A, B and C, and STD"s.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
public health
5,39
23,27
4,25
11,09
44
Total
5,39
23,27
4,25
11,09
44
T1
T2
T3
Ttot
9
0
0
9
IS
FS
OP
Ptot
178
32
21
240
Thesis
Erasmus, V. (2012, april 25). Compliance to hand hygiene guidelines in hospital care. A stepwise
behavioural approach. EUR. Prom./coprom.: Prof. Dr. E.W. Steyerberg & Prof. Dr. H.A. Verbrugh.
Gelder, R. de (2012, april 04). Predicting the benefits and harms of breast cancer screening: current
debates and future directions. EUR (223 pag.). Prom./coprom.: Prof. Dr. H.J. de Koning.
Roon, A.H.C. van (2012, april 18). Colorectal Cancer Screening by Means of Faecal Immunochemical
Testing (FIT). EUR (189 pag.). Prom./coprom.: Prof. Dr. E.J. Kuipers & Prof.Dr. J.D.F. Habbema.
Erasmus MC – Research Annual Report 2012
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Roozenbeek, B. (2012, november 15). Design and analysis of randomized controlled trials in traumatic
brain injury. EUR (209 pag.). Prom./coprom.: Dr. A.I.R. Maas & Prof. Dr. E.W. Steyerberg.
Veen, Y.J.J. van der (2012, januari 18). Cultural tailoring for the promotion of hepatitis B-screening in
Turkish migrants. EUR (176 pag.). Prom./coprom.: Prof. Dr. J.P. Mackenbach & Prof. Dr. J.H. Richardus.
Vugt, H.A. van (2012, oktober 24). Impact of individual risk assessment on prostate cancer diagnosis.
EUR (208 pag.). Prom./coprom.: Prof. Dr. C.H. Bangma, Prof. Dr. E.W. Steyerberg, Dr. M.J.
Roobol-Bouts & Dr. I.J. Korfage.
Westeinde, S.C. van t (2012, juni 21). Lung cancer screening: clinical implications. EUR (217 pag.).
Prom./coprom.: Prof. Dr. H.J. de Koning & Prof. Dr. H.C. Hoogsteden.
Wever, E.M. (2012, oktober 10). Effects of prostate cancer screening and treatment. EUR (214 pag.).
Prom./coprom.: Prof. Dr. H.J. de Koning.
Wilschut, J.A. (2012, april 18). Health effects and costs of colorectal cancerscreening. EUR (172 pag.).
Prom./coprom.: Prof.Dr. J.D.F. Habbema, Prof. Dr. E.J. Kuipers & Dr. M. van Ballegooijen.
Octrooi
Steyerberg, E.W., Roobol-Bouts, M.J., Kranse, M. & Schroder, F.H. (). Data storage device and method
for determining the dependency of the risk for prostate cancer, device and method for indicating a risk
for a disease of an individual. no US 8087576.
Article/Letter to the editor
Aalst, C.M. van der, Iersel, C.A. van, Klaveren, R.J. van, Frenken, F.J.M., Fracheboud, J., Otto, S.J.,
Jong, P.A. de, Oudkerk, M.. & Koning, H.J. de (2012). Generalisability of the results of the
Dutch-Belgian randomised controlled lung cancer CT screening trial (NELSON): Does self-selection play
a role? Lung Cancer, 77(1), 51-57.
Aalst, C.M. van der, Koning, H.J. de, Bergh, K.A.M. van den, Willemsen, MC & Klaveren, R.J. van (2012).
The effectiveness of a computer-tailored smoking cessation intervention for participants in lung cancer
screening: A randomised controlled trial. Lung Cancer, 76(2), 204-210.
Aalten, S.M. van, Broker, M.E.E., Busschbach, J.J. van, Koning, H.J. de, Man, R.A. de, Steegers, E.A.P.,
Steyerberg, E.W., Terkivatan, T. & Ijzermans, J.N.M. (2012). Pregnancy and liver adenoma
management: PALMstudy. BMC Gastroenterology, 12(1), 82.
Agt, H.M.E. van, Fracheboud, J., Steen, A. van der & Koning, H.J. de (2012). Do women make an
informed choice about participating in breast cancer screening? A survey among women invited for a
first mammography screening examination. Patient Education and Counseling, 89(2), 353-359.
Ahmad, R.A., Matthys, F, Dwihardiani, B, Rintiswati, N, Vlas, S.J. de, Mahendradhata, Y & Stuyft, P van
der (2012). Diagnostic work-up and loss of tuberculosis suspects in Jogjakarta, Indonesia. Bmc Public
Health, 12.
Anquinet, L, Rietjens, J.A.C., Seale, C, Seymour, J., Deliens, L. & Heide, A. van der (2012). The Practice
of Continuous Deep Sedation Until Death in Flanders (Belgium), The Netherlands, and the UK: A
Comparative Study. Journal of Pain and Symptom Management, 44(1), 33-43.
Arevalo, JJ, Brinkkemper, T, Heide, A. van der, Rietjens, J.A.C., Ribbe, M, Deliens, L., Loer, SA,
Zuurmond, WWA & Perez, R.S.G.M. (2012). Palliative Sedation: Reliability and Validity of Sedation
Scales. Journal of Pain and Symptom Management, 44 (5), 704-714.
Austin, PC & Steyerberg, E.W. (2012). Interpreting the concordance statistic of a logistic regression
model: Relation to the variance and odds ratio of a continuous explanatory variable. BMC Medical
Research Methodology, 12(1), 82.
Erasmus MC – Research Annual Report 2012
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Austin, PC, Lee, DS, Steyerberg, E.W. & Tu, JV (2012). Regression trees for predicting mortality in
patients with cardiovascular disease: What improvement is achieved by using ensemble-based
methods? Biometrical Journal, 54(5), 657-673.
Baker, SG, Calster, B Van & Steyerberg, E.W. (2012). Evaluating a New Marker for Risk Prediction Using
the Test Tradeoff: An Update. INTERNATIONAL JOURNAL OF BIOSTATISTICS, 8(1).
Beest Smallenburg, V. van, Duijm, L.E.M., Heeten, G.J. den, Groenewoud, J.H., Jansen, F.H.,
Fracheboud, J., Plaisier, M.L., Doorne-Nagtegaal, HJ van & Broeders, M.J.M. (2012). Two-view versus
single-view mammography at subsequent screening in a region of the Dutch breast screening
programme. European Journal of Radiology, 81(9), 2189-2194.
Bekker- Grob, E.W. de, Ryan, M. & Gerard, K (2012). Discrete choice experiments in health economics:
a review of the literature. Health Economics, 21(2), 145-172.
Bekker- Grob, E.W. de, Kok, I.M.C.M. de, Bulten, J, Rosmalen, J.M. van, Vedder, JEM, Arbyn, M.,
Klinkhamer, P.J.J.M., Siebers, AG & Ballegooijen, M. van (2012). Liquid-based cervical cytology using
ThinPrep technology: weighing the pros and cons in a cost-effectiveness analysis. Cancer Causes &
Control, 23(8), 1323-1331.
Bergh, R.C.N. van den, Korfage, I.J. & Bangma, C.H. (2012). Psychological aspects of active
surveillance. Current Opinion in Urology, 22(3), 237-242.
Bergh, R.C.N. van den, Korfage, I.J., Roobol-Bouts, M.J., Bangma, C.H., Koning, H.J. de, Steyerberg,
E.W. & Essink-Bot, M.L. (2012). Sexual function with localized prostate cancer: active surveillance vs
radical therapy. Bju International, 110(7), 1032-1039.
Berghauser Pont, L.M.E., Dammers, R., Schouten, J.W., Lingsma, H.F. & Dirven, C.M.F. (2012). Clinical
Factors Associated With Outcome in Chronic Subdural Hematoma: A Retrospective Cohort Study of
Patients on Preoperative Corticosteroid Therapy. Neurosurgery, 70(4), 873-880.
Berghauser Pont, L.M.E., Dammers, R., Schouten, J.W., Lingsma, H.F. & Dirven, C.M.F. (2012).
Corticosteroid Suppression of Vascular Endothelial Growth Factor and Recurrence of Chronic Subdural
Hematoma Reply. Neurosurgery, 70(5), E1334-E1336.
Biersteker, HAR, Andriessen, TMJC, Horn, J, Franschman, G, Naalt, J van der, Hoedemaekers, CWE,
Lingsma, H.F., Haitsma, I. & Vos, P.E. (2012). Factors influencing intracranial pressure monitoring
guideline compliance and outcome after severe traumatic brain injury. Critical Care Medicine, 40(6),
1914-1922.
Blanker, M.H., Koerhuis-Roessink, M., Swart, S.J., Zuurmond, WWA, Heide, A. van der, Perez, R.S.G.M.
& Rietjens, J.A.C. (2012). Pressure during decision making of continuous sedation in end-of-life
situations in Dutch general practice. BMC Family Practice, 13(1), 68.
Boer, R., Moolgavkar, SH & Levy, DT (2012). Impact of Tobacco Control on Lung Cancer Mortality in the
United States Over the Period 1975-2000-Summary and Limitations. Risk Analysis, 32, S190-S202.
Bonde, JP, Hansen, J., Kolstad, HA, Mikkelsen, S, Olsen, J.H., Blask, DE, Harma, M, Kjuus, H, Koning,
H.J. de, Olsen, J, Moller, M, Schernhammer, ES, Stevens, RG & Akerstedt, T (2012). Work at night and
breast cancer - report on evidence-based options for preventive actions. Scandinavian Journal of Work
Environment & Health, 38(4), 380-390.
Bouwmeester, W., Zuithoff, NPA, Mallett, S, Geerlings, M.I., Vergouwe, Y., Steyerberg, E.W., Altman,
DG & Moons, K.G.M. (2012). Reporting and Methods in Clinical Prediction Research: A Systematic
Review. PLoS Medicine, 9(5).
Erasmus MC – Research Annual Report 2012
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Bruinsma, S.M., Rietjens, J.A.C., Seymour, JE, Anquinet, L & Heide, A. van der (2012). The Experiences
of Relatives With the Practice of Palliative Sedation: A Systematic Review. Journal of Pain and Symptom
Management, 44(3), 431-445.
Bulatovic, M, Heijstek, M.W., Dijkhuizen, E.H.P. van, Wulffraat, N.M., Pluijm, S.M.F. & Jonge, R. de
(2012). Prediction of clinical non-response to methotrexate treatment in juvenile idiopathic arthritis.
Annals of the Rheumatic Diseases, 71(9), 1484-1489.
Bults, M., Beaujean, DJMA, Wijkmans, C.J., Timen, A, Richardus, J.H. & Voeten, H.A.C.M. (2012). Why
did patients with cardiovascular disease in the Netherlands accept Q fever vaccination? Vaccine, 30(23),
3369-3375.
Bults, M., Beaujean, DJMA, Wijkmans, C.J., Timen, A, Richardus, J.H. & Voeten, H.A.C.M. (2012).
Q-koortsvaccinatie van hoogrisicopatiënten. Infectieziekten-Bulletin, 23(8), 280-282.
Calster, B Van, Vergouwe, Y., Looman, C.W.N., Belle, V Van, Timmerman, D & Steyerberg, E.W. (2012).
Assessing the discriminative ability of risk models for more than two outcome categories. European
Journal of Epidemiology, 27(10), 761-770.
Calster, B Van, Belle, V Van, Vergouwe, Y. & Steyerberg, E.W. (2012). Discrimination ability of
prediction models for ordinal outcomes: Relationships between existing measures and a new measure.
Biometrical Journal, 54(5), 674-685.
Calster, B Van, Belle, V Van, Vergouwe, Y., Timmerman, D, Huffel, S Van & Steyerberg, E.W. (2012).
Extending the c-statistic to nominal polytomous outcomes: the Polytomous Discrimination Index.
Statistics in Medicine, 31(23), 2610-2626.
Chang, YJ, Schechter, C.B., Ravesteyn, N.T. van, Near, AM, Heijnsdijk, E.A.M., Adams-Campbell, L,
Levy, D., Koning, H.J. de & Mandelblatt, JS (2012). Collaborative modeling of the impact of obesity on
race-specific breast cancer incidence and mortality. Breast Cancer Research and Treatment, 136(3),
823-835.
Coffeng, L.E., Fobi, G, Ozoh, G, Bissek, AC, Nlatte, BO, Enyong, P, Olinga, JMO, Zoure, HGM, Habbema,
J.D.F., Stolk, W.A., Vlas, S.J. de, Boussinesq, M & Noma, M (2012). Concurrence of dermatological and
ophthalmological morbidity in onchocerciasis. Transactions of the Royal Society of Tropical Medicine
and Hygiene, 106(4), 243-251.
Cramm, J.M., Hartgerink, J.M., Vreede, P.L. de, Bakker, T.J., Steyerberg, E.W., Mackenbach, J.P. &
Nieboer, A.P. (2012). The relationship between older adults' self-management abilities, well-being and
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Hagelstein, M., Kros, L., Lingsma, H.F., Dippel, D.W.J., Koudstaal, P.J. & Visch-Brink, E.G. (2012).
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Janssens, A.C.J.W., Henneman, L, Detmar, S.B., Khoury, MJ, Steyerberg, E.W., Eijkemans, M.J.C.,
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calculates the probability of a positive prostate biopsy in a contemporary clinical cohort. European
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Vugt, H.A. van, Roobol-Bouts, M.J., Poel, HG van der, Muilekom, EHAM van, Busstra, M.B., Kil, P,
Oomens, EH, Leliveld, A, Bangma, C.H., Korfage, I. & Steyerberg, E.W. (2012). Selecting men
diagnosed with prostate cancer for active surveillance using a risk calculator: a prospective impact
study. Bju International, 110(2), 180-187.
Vugt, H.A. van, Steyerberg, E.W., Bul, M., Bangma, C.H. & Roobol-Bouts, M.J. (2012). Het effect van
het gebruik van een prostaatkanker risicowijzer op het aantal biopsiën en de positief voorspellende
waarde: een empirische studie. Tijdschrift voor Urologie, 2(3).
Wagenaar, I.M., Brandsma, W, Post, E., Brakel, W van, Lockwood, D, Nicholls, P., Saunderson, P,
Smith, C., Wilder-Smith, E & Richardus, J.H. (2012). Two randomized controlled clinical trials to study
the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in
leprosy: the TENLEP study protocols. BMC Neurology, 12.
Wang, Y., Klaveren, R.J. van, Bock, G.H. de, Zhao, YR, Vernhout, R, Leusveld, A, Scholten, E,
Verschakelen, J, Mali, W., Koning, H.J. de & Oudkerk, M.. (2012). No Benefit for Consensus Double
Reading at Baseline Screening for Lung Cancer with the Use of Semiautomated Volumetry Software.
Radiology, 262(1), 320-326.
Weir, J, Steyerberg, E.W., Butcher, I, Lu, J., Lingsma, H.F., McHugh, GS, Roozenbeek, B., Maas, AIR &
Murray, G.D. (2012). Does the Extended Glasgow Outcome Scale Add Value to the Conventional
Glasgow Outcome Scale? Journal of Neurotrauma, 29(1), 53-58.
Westeinde, S.C. van t, Horeweg, N., Leyn, P De, Groen, H.J.M., Lammers, JWJ, Weenink, C., Nackaerts,
K & Klaveren, R.J. van (2012). Complications following lung surgery in the Dutch-Belgian randomized
lung cancer screening trial. European Journal of Cardio-Thoracic Surgery, 42(3), 420-429.
Westeinde, S.C. van t, Horeweg, N., Vernhout, R.M., Groen, H.J.M., Lammers, JWJ, Weenink, C.,
Nackaerts, K, Oudkerk, M.., Mali, W., Thunnissen, FB, Koning, H.J. de & Klaveren, R.J. van (2012). The
Role of Conventional Bronchoscopy in the Workup of Suspicious CT Scan Screen-Detected Pulmonary
Nodules. Chest, 142(2), 377-384.
Westmaas, A.H., Kok, G., Vriens, P., Gotz, H.M., Richardus, J.H. & Voeten, H.A.C.M. (2012).
Determinants of intention to get tested for STI/HIV among the Surinamese and Antilleans in the
Netherlands: results of an online survey. BMC Public Health, 9(12).
Erasmus MC – Research Annual Report 2012
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Wever, E.M., Hugosson, J., Heijnsdijk, E.A.M., Bangma, C.H., Draisma, G. & Koning, H.J. de (2012). To
be screened or not to be screened? Modeling the consequences of PSA screening for the individual.
British Journal of Cancer, 107(5), 778-784.
Wielders, CCH, Lier, E.A. van, Klooster, TM van't, Gageldonk-Lafeber, AB van, Wijngaard, C.C. van der,
Haagsma, J.A., Donker, G.A., Meijer, A., Hoek, W van der, Lugner, AK, Kretzschmar, MEE & Sande, MAB
van der (2012). The burden of 2009 pandemic influenza A(H1N1) in the Netherlands. European Journal
of Public Health, 22(1), 150-157.
Wijkerslooth, TR de, Stoop, E.M., Bossuyt, PM, Meijer, G.A., Ballegooijen, M. van, Roon, A.H.C. van,
Stegeman, I, Kraaijenhagen, RA, Fockens, P., Leerdam, M.E. van, Dekker, E. & Kuipers, E.J. (2012).
Immunochemical Fecal Occult Blood Testing Is Equally Sensitive for Proximal and Distal Advanced
Neoplasia. American Journal of Gastroenterology, 107(10), 1570-1578.
Zauber, A.G., Winawer, S.J., O'Brien, MJ, Lansdorp-Vogelaar, I., Ballegooijen, M. van, Hankey, BF, Shi,
WJ, Bond, JH, Schapiro, M, Panish, JF, Stewart, ET & Waye, JD (2012). Colonoscopic Polypectomy and
Long-Term Prevention of Colorectal-Cancer Deaths. New England Journal of Medicine, 366(8), 687-696.
Zelle, S.G., Nyarko, K.B., Bosu, W.K., Aikins, M, Niëns, L.M., Lauer, J.A., Sepulveda, C.R., Hontelez,
J.A.C. & Baltussen, R (2012). Costs, effects and cost-effectiveness of breast cancer control in Ghana.
Tropical Medicine and International Health, 17(8), 1031-1043.
Zhao, JK, Lama, M, Korenromp, E.L., Aylward, P, Shargie, E, Filler, S, Komatsu, R & Atun, R (2012).
Adoption of Rapid Diagnostic Tests for the Diagnosis of Malaria, a Preliminary Analysis of the Global
Fund Program Data, 2005 to 2010. PLoS One, 7(8).
Zuiverloon, T.C.M., Beukers, W., Keur, K.A. van der, Munoz, J.R., Bangma, C.H., Lingsma, H.F.,
Eijkemans, M.J.C., Schouten, JP & Zwarthoff, E.C. (2012). A methylation assay for the detection of
non-muscle-invasive bladder cancer (NMIBC) recurrences in voided urine. Bju International, 109(6),
941-948.
Book - Monograph - Book Editorship
Nagelkerke, N.J.D. (2012). Courtesans and consumption: how sexually transmitted infections drive
tuberculosis epidemics. Delft: Eburon.
Part of book - Abstract
Heide, A. van der & Rietjens, J.A.C. (2012). End-of-life decisions. In J Cohen & L Deliens (Eds.),
public health perspective on end of life care (pp. 50-59). Oxford: Oxford Press.
A
Koning, H.J. de & Maas, P.J. van der (2012). Secondaire preventie. In J.P. Mackenbach & K Stronks
(Eds.), Volksgezondheid en gezondheidszorg (pp. 205-232). Amsterdam: Reed Business.
Middelkoop, B.J.C. & Richardus, J.H. (2012). Uitvoering en organisatie van de publieke
gezondheidszorg. In J.P. Mackenbach & K. Stron ks (Eds.), Volksgezondheid en gezondheidszorg (pp.
265-281). Amsterdam: Business Reed.
Report
Agt, H.M.E. van, Schoonen, H.M.H.J.D., Fracheboud, J. & Koning, H.J. de (2012). Monitor
geinformeerde besluitvorming prenatale screening 2011. Landelijke en regionale uitkomsten.
Rotterdam: ErasmusMC.
Devleesschauwer, B., Havelaar, A, Haagsma, J.A., Praet, N., Dorny, P., Duchateau, L. & Speybroeck, N.
(2012). Le 'DALY Calculator': une interface graphique pour le calcul des DALYs en R. Ghent:
Department of Virology, Parasitology and Immunology.
Devleesschauwer, B., Havelaar, A, Haagsma, J.A., Praet, N., Dorny, P., Duchateau, L. & Speybroeck, N.
(2012). The DALY Calculator: a graphical user interface for stochastic DALY calculation in R. Manual
version 1.1.0. Ghent: Department of Virology, Parasitology and Immunology.
Erasmus MC – Research Annual Report 2012
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Fracheboud, J., Broeders, M.J.M., Bruijn, A.E. de, Gelder, R. de, Heijnsdijk, E.A.M., Heeten, G.J. den,
Holland, R., Ineveld, B.M. van, Luijt, P.A. van, Otten, J.D.M., Otto, S.J., Verbeek, A.L.M. & Koning, H.J.
de (2012). LETB rapportage 2012: Belangrijkste resultaten 2010 bevolkingsonderzoek borstkanker.
NETB report 2012: Main results 2010 breast cancer screening programme in the Netherlands.
Rotterdam/Nijmegen: ErasmusMC/UMC St Radbout.
Fracheboud, J., Agt, H.M.E. van & Koning, H.J. de (2012). Monitoring 2010 van gerapporteerde
verrichtingen van het screeningsprogramma Downsyndroom/Structureel Echoscopisch Onderzoek.
Rotterdam: Maatschappelijke Gezondheidszorg.
Heide, A. van der, Brinkman-Stoppelenburg, A., Delden, H. van, Onwuteaka-Philipsen, B.D., Penning,
C., Jong-Krul, G. de & Bruin, K de (2012). Euthanasie en andere medische beslissingen rond het
levenseinde: sterfgevallenonderzoek 2010. Reeks evaluatie regelgeving: deel 31. Rotterdam. Den
Haag: Centraal bureau voor de statistiek.
Stukart, M.J., Olsthoorn-Heim, E.T.M., Vathorst, S. van de, Heide, A. van der, Tromp, K. & Klerk, C. de
(2012). Tweede evaluatie: wet medisch-wetenschappelijk onderzoek met mensen. Reeks evaluatie
regelgeving: deel 30. Amsterdam ect.: MOAB488 Onderzoek en Advies, Amsterdam. Amsterdam: Met
recht.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-02-65-02 - Determinants of population health and primary prevention
Programme (brief description)
The research programme aims to contribute to a better understanding of the specific role of
social and physical determinants in population health and to develop effective primary preventive
interventions that will enhance population health.
The research on determinants of population health addresses the specific contribution of a wide
array of factors to population health, often by applying novel quantitative methods that are able
to capture the complex interrelationships among individual characteristics and behaviours and
the living and working environment. This knowledge is subsequently used to develop and
evaluate the effectiveness of primary preventive interventions and associated costs and benefits.
These interventions are conducted in a variety of environments, such as schools, workplaces,
and neighbourhoods. The research programme combines 5 research groups: social determinants
of population health, occupational health, cancer surveillance, and youth health care (Prof..dr. A.
Burdorf, Prof.dr. JWW Coebergh, Dr. FJ.van Lenthe, Prof. Dr. H. Raat, Dr. E.F. van Beeck,
Prof.dr. J. Mackenbach) and links with the research group on infectious diseases (Prof.dr. J.H.
Richardus).
Important contributions to public health addressed in this research programme include:
-healthy growth and development of youth
-healthy ageing
-reducing health inequalities
-work and health
-combatting the obesity epidemic
-improved cancer surveillance
-tailored lifestyle interventions
-improving health in cities
-international health
-injury and safety
Key Figures
Department
Sp1
epidemiology
Sp2
Sp3
Sp4
SpTot
4,32
1,36
2,79
8,47
public health
1,81
6,99
2,71
3,2
14,71
Total
1,81
11,31
4,07
5,99
23,18
T1
T2
T3
Ttot
9
1
0
10
IS
FS
OP
Ptot
184
34
12
240
Thesis
Aarts, M. (2012, juni 19). Socioeconomic determinants of cancer risk, detection, and outcome in the
Netherlands since 1990. EUR (262 pag.). Prom./coprom.: Prof. Dr. J.W.W. Coebergh & Dr.Ir. W.J.
Louwman.
Genugten, L. van (2012, maart 16). Prevention of weight gain among overweight adults: development
and evaluation of a computer-tailored self-regulation intervention. EUR (172 pag.). Prom./coprom.:
Prof. Dr. J.P. Mackenbach & Dr. A. Oenema.
Karim-Kos, H.E. (2012, november 21). Progress against cancer in the Netherlands since the late 1980s:
population-based studies of incidence, prognosis and mortality. EUR (314 pag.). Prom./coprom.: Prof.
Dr. J.W.W. Coebergh, L.A.L.M. Kiemeney & Dr. E. de Vries.
Klijs, B. (2012, juni 20). Healthy Ageing: tackling the burden of disease and disability in an ageing
population. EUR (203 pag.). Prom./coprom.: Prof. Dr. J.P. Mackenbach & Dr. W.J. Nusselder.
Erasmus MC – Research Annual Report 2012
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Liu, L. (2012, december 19). Multiple malignancies amongst cancer survivors in the Netherlands since
1989 - implications for surveillance. EUR (229 pag.). Prom./coprom.: Prof. Dr. J.W.W. Coebergh, .Arts I.
Soerjomataram & Dr. E. de Vries.
Majer, I.M. (2012, juni 22). Modelling and forecasting health expectancy. EUR (210 pag.).
Prom./coprom.: Prof. Dr. J.P. Mackenbach & Dr. P.H.M. van Baal.
Prins, R.G. (2012, april 18). Environmental influences on physical activity among adolescents: studies
on determinants and intervention strategies. EUR (219 pag.). Prom./coprom.: Prof.dr.ir. J. Brug, Prof.
Dr. J.P. Mackenbach & Dr. A. Oenema.
Snijder, C.A. (2012, december 13). Work, environment and reproductive health. EUR (281 pag.).
Prom./coprom.: Prof. Dr. Ir. A. Burdorf.
Walter, S. (2012, januari 18). Determinants of healthy ageing: studies of disability and survival among
the elder. EUR (265 pag.). Prom./coprom.: Prof. Dr. J.P. Mackenbach & Prof. Dr. A. Hofman.
Article/Letter to the editor
Aarts, MJ, Hamelinck, VC, Bastiaannet, E, Coebergh, J.W.W., Liefers, GJ, Voogd, A.C., Sangen, M van
der & Louwman, W.J. (2012). Small but significant socioeconomic inequalities in axillary staging and
treatment of breast cancer in the Netherlands. British Journal of Cancer, 107(1), 12-17.
Altena, AM van, Karim-Kos, H.E., Vries, E. de, Kruitwagen, RFPM, Massuger, LFAG & Kiemeney, LA
(2012). Trends in therapy and survival of advanced stage epithelial ovarian cancer patients in the
Netherlands. Gynecologic Oncology, 125(3), 649-654.
Altsitsiadis, E, Undheim, T, Vries, E. de, Hinrichs, B, Stockfleth, E & Trakatelli, M (2012). Health literacy,
sunscreen and sunbed use: an uneasy association. British Journal of Dermatology, 167, 14-21.
Amin, N., Byrne, E, Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I.M., Vink, J.M., Rawal, R,
Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N,
Doering, A, Isaacs, A, Broer, L., Wray, NR, Montgomery, GW, Levy, D., Psaty, B.M., Gudnason, V,
Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, Rooij,
F.J.A. van, Aulchenko, Y.S., Hottenga, J.J., Rivadeneira, FR, Hofman, A., Uitterlinden, A.G., Hammond,
CJ, Shin, SY, Ikram, A., Witteman, J.C.M., Janssens, A.C.J.W., Snieder, H, Tiemeier, H.W.,
Wolfenbuttel, BHR, Oostra, B.A., Heath, AC, Wichmann, E, Spector, T.D., Grabe, HJ, Boomsma, D.I.,
Martin, NG & Duijn, C.M. van (2012). Genome-wide association analysis of coffee drinking suggests
association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17(11), 1116-1129.
Andersson, L., Burdorf, A., Bryngelsson, IL & Westberg, H. (2012). Estimating Trends in Quartz
Exposure in Swedish Iron Foundries-Predicting Past and Present Exposures. Annals of Occupational
Hygiene, 56(3), 362-372.
Avendano Pabon, M. (2012). Correlation or causation? Income inequality and infant mortality in fixed
effects models in the period 1960-2008 in 34 OECD countries. Social Science & Medicine, 75(4),
754-760.
Balak, DMW, Gouw, SC, Plug, I., Mauser-Bunschoten, E.P., Vriends, AHJT, Diemen-Homan, JEM Van,
Rosendaal, F.R. & Bom, J.G. van der (2012). Prenatal diagnosis for haemophilia: a nationwide survey
among female carriers in the Netherlands. Haemophilia, 18(4), 584-592.
Bannink, R., Zwanenburg, E Joosten-van, Looij-Jansen, P van de, As, E. van & Raat, H. (2012).
Evaluation of computer-tailored health education ('E-health4Uth') combined with personal counselling
('E-health4Uth+counselling') on adolescents' behaviours and mental health status: design of a
three-armed cluster randomised controlled trial. Bmc Public Health, 12.
Erasmus MC – Research Annual Report 2012
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Bastiaannet, E, Sampieri, K., Dekkers, O.M., Craen, AJM de, Herk-Sukel, MPP van, Lemmens, V.E.P.P.,
Broek, CBM van den, Coebergh, J.W.W., Herings, R.M.C., Velde, C.J.H. van de, Fodde, R. & Liefers, GJ
(2012). Use of Aspirin postdiagnosis improves survival for colon cancer patients. British Journal of
Cancer, 106(9), 1564-1570.
Batenburg-Eddes, T. van, Butte, D, Looij-Jansen, P van de, Schiethart, W, Raat, H., Waart, F de &
Jansen, W. (2012). Measuring juvenile delinquency: How do self-reports compare with official police
statistics? European Journal of Criminology, 9(1), 23-37.
Beeck, E.F. van, Kramer, W.L.M., Wegman, F & Brugmans, F (2012). Nederland nog niet kindveilig
genoeg. Medisch Contact, 67(48), 2694-2697.
Beenackers, M.A., Kamphuis, C.B.M., Giskes, K., Brug, J., Kunst, A.E., Burdorf, A. & Lenthe, F.J. van
(2012). Socioeconomic inequalities in occupational, leisure-time, and transport related physical activity
among European adults: A systematic review. International Journal of Behavioral Nutrition and Physical
Activity, 9.
Beenackers, M.A., Foster, S., Kamphuis, C.B.M., Titze, S, Divitini, M, Knuiman, M, Lenthe, F.J. van &
Giles-Corti, B (2012). Taking Up Cycling After Residential Relocation Built Environment Factors.
American Journal of Preventive Medicine, 42(6), 610-615.
Bergen, N, Jaddoe, V.W.V.K., Timmermans, S., Hofman, A., Lindemans, J., Russcher, H., Raat, H.,
Steegers-Theunissen, R.P.M. & Steegers, E.A.P. (2012). Homocysteine and folate concentrations in
early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. Bjog-An
International Journal of Obstetrics and Gynaecology, 119(6), 739-751.
Bevaart, F., Mieloo, C.L., Jansen, W., Raat, H., Donker, M.C.H., Verhulst, F.C. & Oort, F.V.A. van (2012).
Ethnic differences in problem perception and perceived need for care for young children with problem
behaviour. Journal of Child Psychology and Psychiatry, 53(10), 1063-1071.
Bhopal, RS, Rafnsson, SB, Agyemang, C, Fagot-Campagna, A, Giampaoli, S., Hammar, N, Harding, S.,
Hedlund, E, Juel, K, Mackenbach, J.P., Primatesta, P, Rey, G, Rosato, M, Wild, S & Kunst, A.E. (2012).
Mortality from circulatory diseases by specific country of birth across six European countries: test of
concept. European Journal of Public Health, 22(3), 353-359.
Boll, D, Verhoeven, RHA, Aa, MA van der, Karim-Kos, H.E., Coebergh, J.W.W., Pauwels, P.J. & Doorn,
H.C. van (2012). Incidence and Survival Trends of Uncommon Corpus Uteri Malignancies in the
Netherlands, 1989-2008. International Journal of Gynecological Cancer, 22(4), 599-606.
Boshuizen, H.C., Lhachimi, S.K., Baal, P.H.M. van, Hoogenveen, R.T., Smit, H.A., Mackenbach, J.P. &
Nusselder, W.J. (2012). The DYNAMO-HIA Model: An Efficient Implementation of a Risk Factor/Chronic
Disease Markov Model for Use in Health Impact Assessment (HIA). Demography, 49(4), 1259-1283.
Bouthoorn, S.H., Gaillard, R., Steegers, E.A.P., Hofman, A., Jaddoe, V.W.V.K., Lenthe, F.J. van & Raat,
H. (2012). Ethnic Differences in Blood Pressure and Hypertensive Complications During Pregnancy The
Generation R Study. Hypertension, 60(1), 198-205.
Bouthoorn, S.H., Lenthe, F.J. van, Hokken-Koelega, A.C.S., Moll, H.A., Tiemeier, H.W., Hofman, A.,
Mackenbach, J.P., Jaddoe, V.W.V.K. & Raat, H. (2012). Head Circumference of Infants Born to Mothers
with Different Educational Levels; The Generation R Study. PLoS One, 7(6).
Brattheim, BJ, Eikemo, T.A., Altreuther, M, Landmark, AD & Faxvaag, A (2012). Regional Disparities in
Incidence, Handling and Outcomes of Patients with Symptomatic and Ruptured Abdominal Aortic
Aneurysms in Norway. European Journal of Vascular and Endovascular Surgery, 44(3), 267-272.
Broek, E.C. van den, Kater, AP, Schans, SAM van de, Karim-Kos, H.E., Janssen-Heijnen, M.L.G., Peters,
WG, Nooijen, P.T.G.A., Coebergh, J.W.W. & Posthuma, E.F.M. (2012). Chronic Lymphocytic Leukaemia
Erasmus MC – Research Annual Report 2012
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in the Netherlands: Trends in incidence, treatment and survival, 1989-2008. European Journal of
Cancer, 48(6), 889-895.
Burdorf, A. (2012). The need for novel strategies to analyze the dynamic pattern of worker's health over
time and the consequences for sustained employability [editorial]. Scandinavian Journal of Work
Environment & Health, 38(6), 485-488.
Bus, P, Aarts, MJ, Lemmens, V.E.P.P., Oijen, MG van, Creemers, G.J., Nieuwenhuijzen, GA, Baal, JW
van & Siersema, P.D. (2012). The Effect of Socioeconomic Status on Staging and Treatment Decisions
in Esophageal Cancer. Journal of Clinical Gastroenterology, 46(10), 833-839.
Chote, A.A., Groot, C.J.M. de, Redekop, K, Hoefman, R, Koopmans, G.T., Jaddoe, V.W.V.K., Hofman,
A., Steegers, E.A.P., Trappenburg, M., Mackenbach, J.P. & Foets, M.M.E. (2012). Differences in Quality
of Antenatal Care Provided by Midwives to Low-Risk Pregnant Dutch Women in Different Ethnic Groups.
Journal of Midwifery & Womens Health, 57(5), 461-468.
Christiansen, S, Kortenkamp, A, Axelstad, M, Boberg, J, Scholze, M, Jacobsen, PR, Faust, M,
Lichtensteiger, W, Schlumpf, M, Burdorf, A. & Hass, U (2012). Mixtures of endocrine disrupting
contaminants modelled on human high end exposures: an exploratory study in rats. International
Journal of Andrology, 35(3), 303-316.
Denktas, S., Bonsel, G.J. & Steegers, E.A.P. (2012). Perinatale gezondheid in Rotterdam: ervaringen na
2 jaar `Klaar voor een kind¿. Nederlands Tijdschrift voor Geneeskunde, 156(29).
Denktas, S., Bakker, R., Vujkovic, M., Bonsel, G.J. & Steegers, E.A.P. (2012). Mogelijke additionele
voordelen van preconceptiezorg bij de vrouw voor de volksgezondheid: Een literatuurstudie. TSG,
90(8), 539-546.
Dieen, JH van, Kuijer, PPFM, Burdorf, A., Marras, W.S. & Adams, MA (2012). Non-specific low back pain.
Lancet (UK), 379(9829), 1874-1874.
Dikken, JL, Lemmens, V.E.P.P., Wouters, MW, Wijnhoven, B.P.L., Siersema, P.D., Nieuwenhuijzen, GA,
Sandick, J.W. van, Cats, A., Verheij, M, Coebergh, J.W.W. & Velde, C.J.H. van de (2012). Increased
incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands.
European Journal of Cancer, 48(11), 1624-1632.
Dreier, R.P. & Mackenbach, J.P. (2012). Lijf- en levensbehoud op het Schouwtoneel des Doods: de
dodendans van medicus Salomon van Rusting. Nederlands Tijdschrift voor Geneeskunde, 156(10).
Drift, MA van der, Karim-Kos, H.E., Siesling, S, Groen, H.J.M., Wouters, MWJM, Coebergh, J.W.W.,
Vries, E. de & Janssen-Heijnen, M.L.G. (2012). Progress in Standard of Care Therapy and Modest
Survival Benefits in the Treatment of Non-small Cell Lung Cancer Patients in the Netherlands in the Last
20 Years. Journal of Thoracic Oncology, 7(2), 291-298.
Duijts, L., Jaddoe, V.W.V.K., Valk, R.J.P. van der, Henderson, JA, Hofman, A., Raat, H., Steegers,
E.A.P., Moll, H.A. & Jongste, J.C. de (2012). Fetal Exposure to Maternal and Paternal Smoking and the
Risks of Wheezing in Preschool Children The Generation R Study. Chest, 141(4), 876-885.
Durmus, B., Ay, L., Duijts, L., Moll, H.A., Hokken-Koelega, A.C.S., Raat, H., Hofman, A., Steegers, E.A.P.
& Jaddoe, V.W.V.K. (2012). Infant diet and subcutaneous fat mass in early childhood: The Generation R
Study. European Journal of Clinical Nutrition, 66(2), 253-260.
Elias, S.G., Grooters, H.G., Bausch-Goldbohm, R.A., Brandt, P.A. van den, Kampman, E, Leeuwen, F.E.
van, Peeters, P.H.M., Vries, E. de, Wigger, S. & Kiemeney, L.A.L.M. (2012). De KWF Kanker Risico Test.
Nederlands Tijdschrift voor Geneeskunde, 156(21).
Erasmus MC – Research Annual Report 2012
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Elskamp, A.B.M., Hartholt, K.A., Patka, P., Beeck, E.F. van & Cammen, T.J.M. van der (2012). Why older
people refuse to participate in falls prevention trials: A qualitative study. Experimental Gerontology,
47(4), 342-345.
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Socio-demographic determinants of worsening in frailty among community-dwelling older people in 11
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Ezendam, N.P.M., Brug, J. & Oenema, A. (2012). Evaluation of the Web-Based Computer-Tailored
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Faiz, Z., Lemmens, V.E.P.P., Siersema, P.D., Nieuwenhuijzen, G.A.P., Wouters, MW, Rozema, T,
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Federico, B., Mackenbach, J.P., Eikemo, T.A. & Kunst, A.E. (2012). Impact of the 2005 smoke-free
policy in Italy on prevalence, cessation and intensity of smoking in the overall population and by
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Federico, B., Capelli, G, Costa, G., Mackenbach, J.P. & Kunst, A.E. (2012). Looking at the smoking
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Fehr, R, Hurley, F, Mekel, OC & Mackenbach, J.P. (2012). Quantitative health impact assessment:
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Ferrandiz, L, Ruiz-de-Casas, A, Trakatelli, M, Vries, E. de, Ulrich, M, Aquilina, S, Saksela, O, Majewski, S,
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Gabriele, C., Silva, L.M., Arends, L.R., Raat, H., Moll, H.A., Hofman, A., Jaddoe, V.W.V.K. & Jongste, J.C.
de (2012). Early respiratory morbidity in a multicultural birth cohort: the Generation R Study. European
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Gallo, V, Mackenbach, J.P., Ezzati, M, Menvielle, G., Kunst, A.E., Rohrmann, S, Kaaks, R, Teucher, B,
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A, Arriola, L, Navarro, C, Gurrea, AB, Khaw, KT, Wareham, N, Key, T, Naska, A, Trichopoulou, A.,
Trichopoulos, D, Masala, G, Panico, S, Contiero, P, Tumino, R, Bueno-de-Mesquita, HB, Siersema, P.D.,
Peeters, PP, Zackrisson, S, Almquist, M, Eriksson, S, Hallmans, G, Skeie, G, Braaten, T, Lund, E, Illner,
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Hartholt, K.A., Polinder, S., Beeck, E.F. van, Velde, N. van der, Lieshout, E.M.M. van, Patka, P. &
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Herk-Sukel, M.P.P., Lemmens, V.E.P.P., Poll-Franse, L.V. van de, Herings, R.M.C. & Coebergh, J.W.W.
(2012). Record linkage for pharmacoepidemiological studies in cancer patients. Pharmacoepidemiology
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M. & Burdorf, A. (2012). Productivity Costs and Medical Costs Among Working Patients With Knee
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Hoedjes, M., Berks, D., Vogel, I., Franx, A., Duvekot, J.J., Oenema, A., Steegers, E.A.P. & Raat, H.
(2012). Motivators and Barriers to a Healthy Postpartum Lifestyle in Women at Increased
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Hoedjes, M., Berks, D., Vogel, I., Franx, A., Oenema, A., Duvekot, J.J., Habbema, J.D.F., Steegers,
E.A.P. & Raat, H. (2012). Postpartum physical activity after preeclampsia. Pregnancy Hypertension,
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Hollander, EL de, Bemelmans, W.J.E., Boshuizen, H.C., Friedrich, N, Wallaschofski, H., Guallar-Castillon,
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Hollestein, L.M., Akker, S.A.W. van den, Nijsten, T., Karim-Kos, H.E., Coebergh, J.W.W. & Vries, E. de
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Hollestein, L.M., Vries, E. de & Nijsten, T. (2012). Trends of cutaneous squamous cell carcinoma in the
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Holterhues, C., Poll-Franse, L.V. van de, Vries, E. de, Neumann, H.A.M. & Nijsten, T.E.C. (2012).
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Hooven, E.H. van den, Pierik, F.H., Kluizenaar, Y. de, Willemsen, S.P., Hofman, A., Ratingen, SW van,
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Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth
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Houweling, A.J., Younes, L, Azad, K, Costello, A. & Fottrell, E (2012). Estimating coverage of a women's
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Jang, SN, Avendano Pabon, M. & Kawachi, I (2012). Informal Caregiving Patterns in Korea and
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Jansen, P.W., Verlinden, M., Berkel, A. van, Mieloo, C, Ende, J. van der, Veenstra, R., Verhulst, F.C.,
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to 59 Years Only, Diagnosed in the Netherlands, 1989 to 2008. Journal of Thoracic Oncology, 7(1),
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Janssen-Heijnen, M.L.G., Maas, H.A.A.M., Siesling, S, Koning, CCE, Coebergh, J.W.W. & Groen, H.J.M.
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Janssens, L., Holtslag, HR, Beeck, E.F. van & Leenen, L.P.H. (2012). The effects of regionalization of
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Murabito, JM, Garcia, ME, Gudnason, V, Tanaka, T, Tranah, GJ, Wallaschofski, H., Kocher, T, Launer,
L.J., Franceschini, N, Schipper, M., Hofman, A. & Tiemeier, H.W. (2012). Genetic, physiological, and
lifestyle predictors of mortality in the general population. American Journal of Public Health, 102(4),
3-10.
Erasmus MC – Research Annual Report 2012
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Wijtzes, A.I., Jansen, W., Kamphuis, C.B.M., Jaddoe, V.W.V.K., Moll, H.A., Tiemeier, H.W., Verhulst,
F.C., Hofman, A., Mackenbach, J.P. & Raat, H. (2012). Increased risk of exceeding
entertainment-media guidelines in preschool children from low socioeconomic background: The
Generation R Study. Preventive Medicine, 55, 325-329.
Witjes, C.D.M., Akker, S.A.W. van den, Visser, O., Karim-Kos, H.E., Vries, E. de, Ijzermans, J.N.M., Man,
R.A. de, Coebergh, J.W.W. & Verhoef, C. (2012). Gallbladder Cancer in the Netherlands: Incidence,
Treatment and Survival Patterns since 1989. Digestive Surgery, 29(2), 92-98.
Witjes, C.D.M., Karim-Kos, H.E., Visser, O., Akker, S.A.W. van den, Vries, E. de, Ijzermans, J.N.M., Man,
R.A. de, Coebergh, J.W.W. & Verhoef, C. (2012). Hepatocellular carcinoma in a low-endemic area:
rising incidence and improved survival. European Journal of Gastroenterology & Hepatology, 24(4),
450-457.
Witjes, C.D.M., Karim-Kos, H.E., Visser, O., Vries, E. de, Ijzermans, J.N.M., Man, R.A. de, Coebergh,
J.W.W. & Verhoef, C. (2012). Intrahepatic cholangiocarcinoma in a low endemic area: rising incidence
and improved survival. HPB, 14(11), 777-781.
Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Jaddoe, V.W.V.K., Hofman, A., Raat, H., Verhulst, F.C.,
Passchier, J. & Tiemeier, H.W. (2012). Concurrent and Longitudinal Bidirectional Relationships Between
Toddlers' Chronic Pain and Mental Health: The Generation R Study. Journal of Pediatric Psychology,
37(5), 546-556.
Zwirs, B, Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Mackenbach, J.P. & Tiemeier, H.W. (2012).
Partner similarity for self-reported antisocial behaviour among married, cohabiting and dating couples:
the Generation R Study. Psychology Crime & Law, 18(4), 335-349.
Part of book - Abstract
Avendano Pabon, M. & Menvielle, G.F.M. (2012). Risk factors in the EURO-GBD-SE project: a rationale,
selection criteria and a proposal for risk factors. In TA Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE:
The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp. 363-407). Rotterdam:
Public Health.
Brug, J., Smit, H.A. & Burdorf, A. (2012). Primaire preventie. In J.P. Mackenbach & K. Stronks (Eds.),
Volksgezondheid en gezondheidszorg (pp. 167-199). Amsterdam: Reed Business.
Eikemo, T.A., Hoffmann, R., Kulhánová, I., Kulik, M.C., Toch, M. & Mackenbach, J.P. (2012). Approach
followed in the EURO-GBD-SE project. In TA Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The
potential for reduction of health inequalities in Europe Part 1 and part 2 (pp. 24-37). Rotterdam: Public
Health.
Eikemo, T.A., Hoffmann, R., Kulhánová, I., Kulik, M.C., Toch, M. & Mackenbach, J.P. (2012). General
introduction to the EURO-GBD-SE project. In TA Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The
potential for reduction of health inequalities in Europe Part 1 and part 2 (pp. 16-24). Rotterdam: Public
Health.
Eikemo, T.A. & Mackenbach, J.P. (2012). Main results, discussion, conclusions and policy
recommendations. In TA Eikemo & Jp Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction of
health inequalities in Europe Part 1 and part 2. Part VI, Policy implications and recommendations (pp.
439-454). Rotterdam: Public Health.
Eikemo, T.A. & Ringdal, K (2012). Socioeconomic inequalities in health in the Western Balkans. In TA
Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in
Europe Part 1 and part 2 (pp. 162-179). Rotterdam: Public Health.
Eikemo, T.A., Hoffmann, R., Kulik, M.C., Kulhánová, I., Toch, M., Menvielle, G.F.M., Costa, G. &
Mackenbach, J.P. (2012). The potential for reduction of health inequalities in Europe. In TA Eikemo & JP
Erasmus MC – Research Annual Report 2012
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Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1
and part 2 (pp. 313-362). Rotterdam: Public Health.
Hafkamp-Groen, E. & Raat, H. (2012). Asthma and health related quality of life in childhood and
adolescence. In C Pereira (Ed.), Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment
(pp. 365-372). Rijeka Croatia: InTech.
Hoffmann, R., Eikemo, T.A., Kulhánová, I. & Mackenbach, J.P. (2012). Development of methods to
assess the potential for reduction of health inequalities. In TA Eikemo & JP Mackenbach (Eds.),
EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
39-75). Rotterdam: Public Health.
Kulhánová, I., Hoffmann, R., Judge, K, Eikemo, T.A. & Mackenbach, J.P. (2012). The potential for
reduction of mortality attributable to low education: evidence from 21 European populations. In TA
Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in
Europe Part 1 and part 2. Rotterdam: Public Health.
Kulik, M.C., Eikemo, T.A. & Mackenbach, J.P. (2012). Does the pattern of socio-economic inequalities in
smoking in Europe depend on the choice of survey? In TA Eikemo & JP Mackenbach (Eds.),
EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
288-304). Rotterdam: Public Health.
Kulik, M.C. (2012). Population attributable fractions (all cause and causespecific) due to different
smoking scenarios, prevalence rates, data sources and relative risks. In TA Eikemo & JP Mackenbach
(Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
275-287). Rotterdam: Public Health.
Kulik, M.C., Hoffmann, R., Judge, K, Eikemo, T.A. & Mackenbach, J.P. (2012). Smoking and the
potential for reduction of inequalities in mortality in Europe. In TA Eikemo & JP Mackenbach (Eds.),
EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
241-274). Rotterdam: Public Health.
Lundberg, O., Ostergren, O., Menvielle, G.F.M., Kulhánová, I., Eikemo, T.A. & Mackenbach, J.P. (2012).
. Inequalities in mortality across Europe: an international comparative study. In TA Eikemo & JP
Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1
and part 2 (pp. 80-108). Rotterdam: Public Health.
Mackenbach, J.P. (2012). Gezondheid van de Nederlandse bevolking. In J.P. Mackenbach & K. Stronks
(Eds.), Volksgezondheid en gezondheidszorg (pp. 71-130). Amsterdam: Reed Business.
Mackenbach, J.P. & Stronks, K. (2012). Inleiding. In J.P. Mackenbach & K. Stronks (Eds.),
Volksgezondheid en gezondheidszorg (pp. 15-41).
Maki, N., Martikainen, P., Eikemo, T.A., Menvielle, G.F.M., Lundberg, O., Ostergren, O., Jasilionis, D &
Mackenbach, J.P. (2012). Educational differences in disability-free life expectancy:a comparative study
of long-standing activity limitation in eight European countries. In TA Eikemo & JP Mackenbach (Eds.),
EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
180-194). Rotterdam: Public Health.
Maki, N., Martikainen, P.T., Eikemo, T.A., Menvielle, G.F.M., Lundberg, O., Ostergren, O. &
Mackenbach, J.P. (2012). The potential for reduction of educational differences in life expectancy in five
European countries. In TA Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The potential for reduction
of health inequalities in Europe Part 1 and part 2 (pp. 305-312). Rotterdam: Public Health.
Toch, M. & Menvielle, G.F.M. (2012). Correction factor to to estimate the mortality differences by
occupational class taking into account economically inactive men. In TA Eikemo & JP Mackenbach
Erasmus MC – Research Annual Report 2012
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(Eds.), EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
141-149). Rotterdam: Public Health.
Toch, M., Menvielle, G.F.M., Eikemo, T.A., Jasilionis, D & Mackenbach, J.P. (2012). Occupational class
inequalities in all-cause and causespecific mortality among middle aged men in 14 European countries
during the early 2000s. In TA Eikemo & JP Mackenbach (Eds.), EURO-GBD-SE: The potential for
reduction of health inequalities in Europe Part 1 and part 2 (pp. 118-140). Rotterdam: Public Health.
Toch, M., Eikemo, T.A. & Mackenbach, J.P. (2012). Occupational class inequalities in self-assessed
health in middle-aged men and women in Europe. In TA Eikemo & JP Mackenbach (Eds.),
EURO-GBD-SE: The potential for reduction of health inequalities in Europe Part 1 and part 2 (pp.
150-161). Rotterdam: Public Health.
Velden, J. van der & Mackenbach, J.P. (2012). Gezondheid en ziekte in de wereld. In J.P. Mackenbach &
K. Stronks (Eds.), Volksgezondheid en gezondheidszorg (pp. 45-65). Amsterdam: Reed Business.
Book Editorship
Eikemo, T.A. & Mackenbach, J.P. (Eds.). (2012). . EURO-GBD-SE: The potential for reduction of health
inequalities in Europe. Part 1 and part 2. Rotterdam: Public Health.
Mackenbach, J.P. & Stronks, K. (Eds.). (2012). Volksgezondheid en gezondheidszorg. 6e, geheel herz.
dr. Amsterdam: Reed Business.
Peters, F., Nusselder, W.J. & Mackenbach, J.P. (Eds.). (2012). . The longevity risk of the Dutch Actuarial
Association¿s projection model. Design Paper 11. Tilburg: Tilburg University.
Report
Haagsma, J.A., Polinder, S. & Havelaar, A.H. (2012). Development of European-tailored set of disability
weights for communicable diseases. Technical report. (OJ/27/04/2011-PROC/2011/031). Rotterdam:
Public Health.
Hertog, P. den, Polinder, S., Beeck, E.F. van, Valkenburg, H.A., Nijman, S & Toet, H. (2012). Validiteit
van monitoring van het letselpreventiebeleid met behulp van intermediaire veligheidsmaten.
Rotterdam: Consument en Veiligheid/Public Health.
Polinder, S., Toet, H., Panneman, M & Beeck, E.F. van (2012). Methodological approaches for
cost-effectiveness and cost-utility analysis of injury prevention measures. Copenhagen: WHO regional
office for Europe.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-02-67-01 - Clinical research in general practice.
Programme (brief description)
The aim of research activities of the Department of General Practice is to do research of
academic quality, based on and derived from issues in general practice, aimed at the
enhancement of the quality of general practice and supporting the academic workplace of
general practice.The research encompasses the scientific basis and quality improvement of
general practice. The most important components are studies of occurrence and course of
disease and clinical research into the effects of preventive, diagnostic, and therapeutic
strategies in general practice by clinical epidemiologic studies and randomised trials. The results
of these studies are used in decision analysis and guideline development. Within this research
programme patient-centered studies in the field of musculoskeletal disorders and diseases in
childhood dominate. In view of the comprehensive approach of general practice other fields are
occasionally addressed as well.Main research themes of the chair of Intellectual Disability
Medicine (Prof Evenhuis) are 'Cerebral visual impairment', 'Comorbidity in children with severe
generalized cerebral palsy' and, since 2008, `Healthy Ageing and intellectual disabilities’.
Key Figures
Department
family practice
Total
Sp1
Sp2
Sp3
Sp4
SpTot
12,23
5,17
4,03
1,59
23,02
12,23
5,17
4,03
1,59
23,02
T1
T2
T3
Ttot
IS
FS
OP
Ptot
8
0
0
8
54
12
25
99
Thesis
Bot, C.M.A. de (2012, december 12). House dust mite induced allergic rhinitis in children in primary
care. Epidemiology and management. EUR (167 pag.). Prom./coprom.: Prof. Dr. P.J.E. Bindels, Dr. H.
Moed & Dr. J.C. van der Wouden.
Hermans, H. (2012, mei 30). Depression and anxiety in older adults with intellectual disabilities. EUR
(212 pag.). Prom./coprom.: Prof. Dr. H.M. Evenhuis.
Hilgenkamp, T.I.M. (2012, mei 09). Physical activity and fitness in older adults with intellectual
disabilities. EUR (236 pag.). Prom./coprom.: Prof. Dr. H.M. Evenhuis & R van Wijck.
Linschoten, R. van (2012, april 11). Patellofemoral pain syndrome and exercise therapy. EUR (218
pag.). Prom./coprom.: Prof. Dr. S.M.A. Bierma-Zeinstra, Prof. Dr. J.A.N. Verhaar & Dr. M. van
Middelkoop.
Mergler, S. (2012, juni 27). Bone quality in children with severe neurological impairment and intellectual
disability. Diagnostic methods and determinants of low bone quality. EUR (212 pag.). Prom./coprom.:
Prof. Dr. H.M. Evenhuis.
Schiphof, D. (2012, februari 01). Identifying knee osteoarthritis. EUR (182 pag.). Prom./coprom.: Prof.
Dr. S.M.A. Bierma-Zeinstra & Prof. Dr. Ir. H.H. Weinans.
Verkleij, S.P.J. (2012, december 19). Pain, course and treatment of osteoarthritis in primary care. EUR
(165 pag.). Prom./coprom.: Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. P.A.J. Luijsterburg.
Wagemakers, H.P.A. (2012, november 28). Traumatic knee disorders in adults in General Practice. EUR
(148 pag.). Prom./coprom.: Prof. Dr. S.M.A. Bierma-Zeinstra, Prof. Dr. B.W. Koes & Dr. P.A.J.
Luijsterburg.
Erasmus MC – Research Annual Report 2012
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Article/Letter to the editor
Bastiaanse, L.P., Vlasveld, G, Penning, C. & Evenhuis, H.M. (2012). FEASIBILITY AND RELIABILITY OF
THE MINI NUTRITIONAL ASSESSMENT (MNA) IN OLDER ADULTS WITH INTELLECTUAL DISABILITIES.
Journal of Nutrition Health & Aging, 16(9), 759-762.
Bastiaanse, L.P., Hilgenkamp, T.I.M., Echteld, M.A. & Evenhuis, H.M. (2012). Prevalence and associated
factors of sarcopenia in older adults with intellectual disabilities. Research in Developmental Disabilities,
33(6), 2004-2012.
Bastick, A.N. (2012). Incident knee osteoarthritis-related outcomes and slower walking speed:
Comment on the article by Purser et al. Arthritis Care & Research, 64(12), 1937-1938.
Bokhoven, M.A. van, Koch, H., Weijden, T. van der, Weekers-Muyres, AHM, Bindels, P.J.E., Grol,
R.P.T.M. & Dinant, GJ (2012). The effect of watchful waiting compared to immediate test ordering
instructions on general practitioners' blood test ordering behaviour for patients with unexplained
complaints; a randomized clinical trial (ISRCTN55755886). Implementation Science, 7(29).
Boot, F.H., Pel, J.J.M., Evenhuis, H.M. & Steen, J. van der (2012). Factors related to impaired visual
orienting behavior in children with intellectual disabilities. Research in Developmental Disabilities,
33(5), 1670-1676.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P. & Wouden, J.C. v.d. (2012). SIT: efficacy depends on product, not on route of
application Reply. Pediatric Allergy and Immunology, 23(4), 401-402.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P.J.E. & Wouden, J.C. v.d. (2012). Sublingual immunotherapy not effective in house
dust mite-allergic children in primary care. Pediatric Allergy and Immunology, 23(2), 151-159.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P.J.E. & Wouden, J.C. van der (2012). Sublinguale immunotherapie bij kinderen met
allergische rinitis in de huisartsenpraktijk. Nederlands Tijdschrift voor Geneeskunde, 156.
Clockaerts, S.B.F., Osch, G.J.V.M. van, Bastiaansen-Jenniskens, Y.M., Verhaar, J.A.N., Glabbeek, F Van,
Meurs, J.B.J. van, Kerkhof, J.M., Hofman, A., Stricker, B.H.C. & Bierma-Zeinstra, S.M.A. (2012). Statin
use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study.
Annals of the Rheumatic Diseases, 71(5), 642-647.
Dijk, E. van, Hilgenkamp, T.I.M., Evenhuis, H.M. & Echteld, M.A. (2012). Exploring the use of actigraphy
to investigate sleep problems in older people with intellectual disability. Journal of Intellectual Disability
Research, 56(2), 204-211.
Echteld, M.A., Schoufour, J.D., Bastiaanse, L.P., Hilgenkamp, T.I.M., Hermans, H., Wijngaarden, J.P. &
Evenhuis, H.M. (2012). Vroeg oud en extra kwetsbaar. Markant, 8, 4-7.
Elshout, G., Kool, M., Wouden, J.C. van der, Moll, H.A., Koes, B.W. & Berger, M.Y. (2012). Antibiotic
prescription in febrile children: a cohort study during out-of-hours primary care. Journal of the American
Board of Family Medicine, 25, 810-818.
Evenhuis, H.M., Hermans, H., Hilgenkamp, T.I.M., Bastiaanse, L.P. & Echteld, M.A. (2012). Frailty and
Disability in Older Adults with Intellectual Disabilities: Results from the Healthy Ageing and Intellectual
Disability Study. Journal of American Geriatrics Society, 60(5), 934-938.
Evenhuis, H.M., Hermans, H., Hilgenkamp, T.I.M., Bastiaanse, L.P. & Echteld, M.A. (2012).
Kwetsbaarheid in de oudere populatie met verstandelijke handicaps. Nederlands Tijdschrift voor
Geneeskunde, 156.
Erasmus MC – Research Annual Report 2012
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Ferreira, ML, Herbert, R.D., Crowther, MJ, Verhagen, A.P. & Sutton, A.J. (2012). When is a further
clinical trial justified? British Medical Journal, 345.
Gebremariam, L., Koes, B.W., Peul, W.C. & Huisstede, B.M.A. (2012). Evaluation of Treatment
Effectiveness for the Herniated Cervical Disc. Spine, 37(2), E109-E118.
Gieteling, M.J., Leeuwen, Y. van, Passchier, J., Koes, B.W. & Berger, M.Y. (2012). The course of mental
health problems in children presenting with abdominal pain in general practice. Scandinavian Journal of
Primary Health Care, 30(2), 114-120.
Grieken, A. van, Ezendam, N.P.M., Paulis, W.D., Wouden, J.C. v.d. & Raat, H. (2012). Primary
prevention of overweight in children and adolescents: a meta-analysis of the effectiveness of
interventions aiming to decrease sedentary behaviour. International Journal of Behavioral Nutrition and
Physical Activity, 9(61).
Haan, A. de & Berg, P.J. van den (2012). Thuisbehandeling van condylomata acminata. Huisarts en
Wetenschap, 55.
Hermans, H., Jelluma, N, Pas, FH van der & Evenhuis, H.M. (2012). Feasibility, reliability and validity of
the Dutch translation of the Anxiety, Depression And Mood Scale in older adults with intellectual
disabilities. Research in Developmental Disabilities, 33(2), 315-323.
Hermans, H. & Evenhuis, H.M. (2012). Life events and their associations with depression and anxiety in
older people with intellectual disabilities: Results of the HA-ID study. Journal of Affective Disorders,
138(1-2), 79-85.
Hermans, J., Koopmanschap, M.A., Bierma-Zeinstra, S.M.A., Linge, J.H. van, Verhaar, J.A.N., Reijman,
M. & Burdorf, A. (2012). Productivity Costs and Medical Costs Among Working Patients With Knee
Osteoarthritis. Arthritis Care & Research, 64(6), 853-861.
Hilgenkamp, T.I.M., Wijck, R van & Evenhuis, H.M. (2012). Feasibility and reliability of physical fitness
tests in older adults with intellectual disability: A pilot study. Journal of Intellectual & Developmental
Disability, 37(2), 158-162.
Hilgenkamp, T.I.M., Wijck, R van & Evenhuis, H.M. (2012). Low physical fitness in older adults with ID:
Results of the HA-ID study. Research in Developmental Disabilities, 33, 1048-1058.
Hilgenkamp, T.I.M., Reis, D, Wijck, R van & Evenhuis, H.M. (2012). Physical activity levels in older
adults with intellectual disabilities are extremely low. Research in Developmental Disabilities, 33(2),
477-483.
Hoeven, T.A. & Vos, BC de (2012). Weight loss in a commercial setting. Lancet (UK), 379(9820),
1003-1003.
Holla, JFM, Leeden, M van der, Roorda, L.D., Bierma-Zeinstra, S.M.A., Damen, J., Dekker, J. &
Steultjens, MPM (2012). Diagnostic accuracy of range of motion measurements in early symptomatic
hip and/or knee osteoarthritis. Arthritis Care & Research, 64(1), 59-65.
Hoogeboom, TJ, Snijders, GF, Cats, H.A., Bie, R.A. de, Bierma-Zeinstra, S.M.A., Hoogen, F.H.J van den,
Riel, PLCM van, Emans, PJ, Wesseling, J., Broeder, AA den & Ende, C.H.M. van den (2012). Prevalence
and predictors of health care use in patients with early hip or knee osteoarthritis: two-year follow-up
data from the CHECK cohort. Osteoarthritis and Cartilage, 20(6), 525-531.
Jacobs, WCH, Arts, MP, Tulder, M.W. van, Rubinstein, SM, Middelkoop, M. van, Ostelo, RW, Verhagen,
A.P., Koes, B.W. & Peul, W.C. (2012). Surgical techniques for sciatica due to herniated disc, a
systematic review. European Spine Journal, 21(11), 2232-2251.
Erasmus MC – Research Annual Report 2012
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Kinds, MB, Marijnissen, ACA, Vincken, KL, Viergever, M.A., Drossaers-Bakker, KW, Bijlsma, J.W.J.,
Bierma-Zeinstra, S.M.A., Welsing, P.M.J. & Lafeber, FPJG (2012). Evaluation of separate quantitative
radiographic features adds to the prediction of incident radiographic osteoarthritis in individuals with
recent onset of knee pain: 5-year follow-up in the CHECK cohort. Osteoarthritis and Cartilage, 20(6),
548-556.
Klerk, B.M. de, Willemsen, S.P., Schiphof, D., Meurs, J.B.J. van, Koes, B.W., Hofman, A. &
Bierma-Zeinstra, S.M.A. (2012). Development of radiological knee osteoarthritis in patients with knee
complaints. Annals of the Rheumatic Diseases, 71(6), 905-910.
Koes, B.W. (2012). Manual therapy for neck pain: increasing evidence for effectiveness. Nederlands
Tijdschrift voor Geneeskunde, 156.
Koning, S., Sande, R. van der, Verhagen, A.P., Suijlekom-Smit, L.W.A. van, Morris, A.D., Butler, C.C.,
Berger, M.Y. & Wouden, J.C. van der (2012). Interventions for impetigo. Cochrane Database
Systematics Review, 1.
Krul, M., Wouden, J.C. van der, Suijlekom-Smit, L.W.A. van & Koes, B.W. (2012). Manipulative
interventions for reducing pulled elbow in young children. Cochrane Database Systematics Review, 1.
Krul, M. (2012). Vaginale jeuk. Huisarts en Wetenschap, 1.
Laar, I.M.B.H. van de, Linde, D. van der, Oei, E.H.G., Bos, P.K., Bessems, J.H.J.M., Bierma-Zeinstra,
S.M.A., Meer, B.L. van, Pals, G., Oldenburg, R.A., Bekkers, J.A., Moelker, A., Graaf, B.M. de, Matyas, G,
Frohn-Mulder, I.M.E., Timmermans, J, Hilhorst-Hofstee, Y., Cobben, JM, Bruggenwirth, H.T., Laer, L
Van, Loeys, B, Backer, J De, Coucke, P.J., Dietz, HC, Willems, P..J., Oostra, B.A., Paepe, A. de,
Roos-Hesselink, J.W., Bertoli-Avella, A.M. & Wessels, M.W. (2012). Phenotypic spectrum of the
SMAD3-related aneurysms-osteoarthritis syndrome. Journal of Medical Genetics, 49(1), 47-57.
Lankhorst, N.E., Bierma-Zeinstra, S.M.A. & Middelkoop, M. van (2012). Risk Factors for Patellofemoral
Pain Syndrome: A Systematic Review. Journal of Orthopaedic & Sports Physical Therapy, 42(2), 81-94.
Mark, LB van der, Lyklema, P.E., Geskus, RB, Mohrs, J, Bindels, P.J.E., Aalderen, W.M.C. van & Riet, G.
ter (2012). A systematic review with attempted network meta-analysis of asthma therapy. BMC
Pulmonary Medicine, 12.
Mark, LB van der, Wonderen, KE van, Mohrs, J, Bindels, P.J.E., Puhan, MA & Riet, G. ter (2012). The
effect of two lottery-style incentives on response rates to postal questionnaires in a prospective cohort
study in preschool children at high risk of asthma: a randomized trial. BMC Medical Research
Methodology, 12.
Michaleff, ZA, Maher, CG, Verhagen, A.P., Rebbeck, T & Lin, CWC (2012). Accuracy of the Canadian
C-spine rule and NEXUS to screen for clinically important cervical spine injury in patients following blunt
trauma: a systematic review. CMAJ. Canadian Medical Association Journal, 184(16), E867-E876.
Middelkoop, M. van, Rubinstein, SM, Ostelo, R, Tulder, M.W. van, Peul, W, Koes, B.W. & Verhagen, A.P.
(2012). No additional value of fusion techniques on anterior discectomy for neck pain: A systematic
review. Pain, 153(11), 2167-2173.
Middelkoop, M. van, Rijn, R.M. van, Verhaar, J.A.N., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2012).
Re-sprains during the first 3 months after initial ankle sprain are related to incomplete recovery: an
observational study. JOURNAL OF PHYSIOTHERAPY, 58(3), 181-188.
Moed, H., Yang, Q, Oranje, A.P., Panda, S. & Wouden, J.C. van der (2012). Different strategies for
using topical corticosteroids for established eczema: Cochrane. Cochrane Database Systematics
Review, 10.
Erasmus MC – Research Annual Report 2012
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Mutsaers, J.H.A.M., Peters, R., Pool-Goudzwaard, A.L., Koes, B.W. & Verhagen, A.P. (2012).
Psychometric properties of the Pain Attitudes and Beliefs Scale for Physiotherapists: A systematic
review. Manual Therapy, 17(3), 213-218.
Oort, L. van, Berg, T. van den, Koes, B.W., Vet, RHCW de, Anema, HJR, Heymans, M.W. & Verhagen,
A.P. (2012). Preliminary state of development of prediction models for primary care physical therapy: a
systematic review. Journal of Clinical Epidemiology, 65(12), 1257-1266.
Paulis, W.D., Jong, A. de, Avendonk, MJP van, Boukes, F.S. & Wouden, J.C. van der (2012). Kinderen
met obesitas in de huisartsenpraktijk een online onderzoek onder huisartsen. TSG, 90, 171-175.
Pinto, RZ, Maher, CG, Ferreira, ML, Ferreira, PH, Hancock, M, Oliveira, VC, McLachlan, AJ & Koes, B.
(2012). Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis. British
Medical Journal, 344.
Richardson, LE, Dorleijn, D.M.J. & Verhagen, A.P. (2012). Autograft Hamstring vs Patellar Tendon ACL
Reconstruction. American Journal of Sports Medicine, 40(8), NP15-NP15.
Rijn, R.M. van, Wassenaar, M, Verhagen, A.P., Ostelo, R.W.J.G., Ginai, A.Z., Boer, MR de, Tulder, M.W.
van & Koes, B.W. (2012). Computed tomography for the diagnosis of lumbar spinal pathology in adult
patients with low back pain or sciatica: a diagnostic systematic review. European Spine Journal, 21(2),
228-239.
Scheele, J., Schepper, E.I.T. de, Meurs, J.B.J. van, Hofman, A., Koes, B.W., Luijsterburg, P.A.J. &
Bierma-Zeinstra, S.M.A. (2012). Association between spinal morning stiffness and lumbar disc
degeneration: the Rotterdam Study. Osteoarthritis and Cartilage, 20(9), 982-987.
Scheele, J., Luijsterburg, P.A.J., Bierma-Zeinstra, S.M.A. & Koes, B.W. (2012). Course of back
complaints in older adults: a systematic literature review. European Journal of Physical and
Rehabilitation Medicine, 48(3), 379-386.
Schellingerhout, J.M., Verhagen, A.P., Heymans, M.W., Koes, B.W., Vet, HC de & Terwee, C.B. (2012).
Measurement properties of disease-specific questionnaires in patients with neck pain: a systematic
review. Quality of Life Research, 21(4), 659-670.
Schoufour, J.D. & Elshout, G. (2012). Outdoor sports and risk of skin lesions. British Journal of
Dermatology, 166(6), 1367-1367.
Schreuder, F, Bernsen, R.M.D. & Wouden, J.C. v.d. (2012). Vitamin D Supplementation for Nonspecific
Musculoskeletal Pain in Non-Western Immigrants: A Randomized Controlled Trial. Annals of family
medicine, 10(6), 547-555.
Spee, L.A.A., Echteld, M.A. & Djasmo, D (2012). Ruling out coronary heart disease in primary care:
external validation of a clinical prediction rule. British Journal of General Practice, 62.
Spil, WE van, Welsing, P.M.J., Kloppenburg, M, Bierma-Zeinstra, S.M.A., Bijlsma, J.W.J., Mastbergen,
SC & Lafeber, FPJG (2012). Cross-sectional and predictive associations between plasma adipokines and
radiographic signs of early-stage knee osteoarthritis: data from CHECK. Osteoarthritis and Cartilage,
20(11), 1278-1285.
Swart, N.M., Linschoten, R. van, Bierma-Zeinstra, S.M.A. & Middelkoop, M. van (2012). The additional
effect of orthotic devices on exercise therapy for patients with patellofemoral pain syndrome: a
systematic review. British Journal of Sports Medicine, 46(8), 570-577.
Thoomes, E.J., Scholten-Peeters, GGM, Boer, A.J. de, Olsthoorn, R.A., Verkerk, K., Lin, C. & Verhagen,
A.P. (2012). Lack of uniform diagnostic criteria for cervical radiculopathy in conservative intervention
studies: a systematic review. European Spine Journal, 21(8), 1459-1470.
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Veen, M., Bareman, F.P., Beekman, M & Bueving, H.J. (2012). Consultvoering van aios en ervaren
huisartsen. Huisarts en Wetenschap, 55, 94-95.
Verhagen, A.P., Oort, L. van, Borghouts, J.A.J. & Heijmans, M (2012). Klinische predictie modellen.
Nederlands Tijdschrift voor Fysiotherapie.
Verkerk, K., Luijsterburg, P.A.J., Miedema, H.S., Pool-Goudzwaard, A. & Koes, B.W. (2012). Prognostic
Factors for Recovery in Chronic Nonspecific Low Back Pain: A Systematic Review. Physical Therapy,
92(9), 1093-1108.
Verkleij, S.P.J., Hoekstra, T, Rozendaal, R.M., Waarsing, J.H., Koes, B.W., Luijsterburg, P.A.J. &
Bierma-Zeinstra, S.M.A. (2012). Defining discriminative pain trajectories in hip osteoarthritis over a
2-year time period. Annals of the Rheumatic Diseases, 71(9), 1517-1523.
Verlee, L., Verheij, T.J.M., Hopstaken, R.M., Prins, J.M., Salome, Ph.L. & Bindels, P.J.E. (2012).
Summary of NHG Practice Guideline 'Acute cough. Nederlands Tijdschrift voor Geneeskunde, 156.
Verwoerd, J.H., Luijsterburg, P.A.J., Timman, R., Koes, B.W. & Verhagen, A.P. (2012). A single question
was as predictive of outcome as the Tampa Scale for Kinesiophobia in people with sciatica: an
observational study. JOURNAL OF PHYSIOTHERAPY, 58(4), 249-254.
Verwoerd, J.H. & Mattace Raso, F.U.S. (2012). Mild Cognitive Impairmen. Huisarts en Wetenschap, 55,
464-467.
Vijven, J.P.J. van, Luijsterburg, P.A.J., Verhagen, A.P., Osch, G.J.V.M. van, Kloppenburg, M &
Bierma-Zeinstra, S.M.A. (2012). Symptomatic and chondroprotective treatment with collagen
derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20(8), 809-821.
Vissers, M.M., Bussmann, J.B.J., Verhaar, J.A.N., Busschbach, J.J. van, Bierma-Zeinstra, S.M.A. &
Reijman, M. (2012). Psychological Factors Affecting the Outcome of Total Hip and Knee Arthroplasty: A
Systematic Review. Seminars in Arthritis and Rheumatism, 41(4), 576-588.
Vos, BC de & Wouw, E van de (2012). Comments on "Effect of three weeks of continuous airway
pressure treatment on mood in patients with obstructive sleep apnoea: A randomized
placebo-controlled trial". SLEEP MEDICINE, 13(7), 965-966.
Vrielink, G.J. (2012). Yoga als steuntje in de rug? Huisarts en Wetenschap, 4.
Wagemakers, H.P.A., Luijsterburg, P.A.J., Heintjes, E.M., Berger, M.Y., Verhaar, J.A.N., Koes, B.W. &
Bierma-Zeinstra, S.M.A. (2012). Predictors of persistent complaints after a knee injury in primary care.
British Journal of General Practice, 62(601), 516-566.
Wassenaar, M, Rijn, R.M. van, Tulder, M.W. van, Verhagen, A.P., Windt, D.A.W.M., Koes, B.W., Boer,
MR de, Ginai, A.Z. & Ostelo, R.W.J.G. (2012). Magnetic resonance imaging for diagnosing lumbar spinal
pathology in adult patients with low back pain or sciatica: a diagnostic systematic review. European
Spine Journal, 21(2), 220-227.
Winter, C.F. de, Bastiaanse, L.P., Hilgenkamp, T.I.M., Evenhuis, H.M. & Echteld, M.A. (2012).
Cardiovascular risk factors (diabetes, hypertension, hypercholesterolemia and metabolic syndrome) in
older people with intellectual disability: Results of the HA-ID study. Research in Developmental
Disabilities, 33(6), 1722-1731.
Winter, C.F. de, Bastiaanse, L.P., Hilgenkamp, T.I.M., Evenhuis, H.M. & Echteld, M.A. (2012).
Overweight and obesity in older people with intellectual disability. Research in Developmental
Disabilities, 33(2), 398-405.
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Wouw, E van de, Evenhuis, H.M. & Echteld, M.A. (2012). Prevalence, associated factors and treatment
of sleep problems in adults with intellectual disability: A systematic review. Research in Developmental
Disabilities, 33(4), 1310-1332.
Part of book - Abstract
Bindels, P.J.E. (2012). Astma. In PJE Bindels & CMF Kneepkens (Eds.), Kindergeneeskunde; Tweede,
geheel herziene druk (pp. 28). Houten: Bohn Stafleu van Loghum.
Bindels, P.J.E. (2012). Hoesten. In PJE Bindels & CMF Kneepkens (Eds.), Kindergeneeskunde; Tweede,
geheel herziene druk (pp. 11). Houten: Bohn Stafleu van Loghum.
Borghouts, J.A.J., Oort, L. van, Bie, R.A. de & Verhagen, A.P. (2012). Predictie, het voorspellen van
natuurlijk beloop. In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap;
lesbrieven voor de fysiotherapeut (pp. 19). Houten: Bohn Stafleu van Loghum.
Eusman, J.P. (2012). Onschuldig pubergedrag? In W. de Ruijter, A Hendriks & M Verkerk (Eds.),
Huisarts tussen individu en familie (pp. 69-72). Houten: Van Gorcum.
Felius, A., Bindels, P.J.E. & Delemarre- van de Waal, H.A. (2012). Overgewicht en obesitas. In PLE
Bildels & CMF Kneepkens (Eds.), Kindergeneeskunde; Tweede, geheel herziene druk (pp. 17). Houten:
Bohn Stafleu van Loghum.
Oort, L. van, Borghouts, J.A.J., Berger, M.Y. & Verhagen, A.P. (2012). Klinische predictiemodelen; wat
moeten we ermee? In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap;
lesbrieven voor de fysiotherapeut (pp. 20). Houten: Bohn Stafleu van Loghum.
Oranje, A.P. & Bindels, P.J.E. (2012). Constitutioneel eczeem. In PJE Bindels & CMF Kneepkens (Eds.),
Kindergeneeskunde; Tweede, geheel herziene druk (pp. 14). Houten: Bohn Stafleu van Loghum.
Ostelo, R.W.J.G., Bie, R.A. de, Lenssen, A.F. & Verhagen, A.P. (2012). Evidence-based practice: een
inleiding. In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap; Houten: Bohn
Stafleu van Loghum.
Ostelo, R.W.J.G., Beurskens, A.J.H.M. & Verhagen, A.P. (2012). Zicht op blinderen. In RWGJ Ostelo, AP
Verhagen & NCW de Vet (Eds.), Onderwijs in Wetenschap; lesbrieven voor de fysiotherapeut (pp. 22).
Houten: Bohn Stafleu van Loghum.
Scholten, R.J.P.M., Verhagen, A.P. & Ostelo, R.W.J.G. (2012). Interpretatie van resultaten uit
wetenschappelijk onderzoek. In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in
Wetenschap; lesbrieven voor de fysiotherapeut. Houten: Bohn Stafleu van Loghum.
Verhagen, A.P., Ostelo, R.W.J.G. & Rademaker, A. (2012). Alternatieven voor de p-waarde. In RWGJ
Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap; lesbrieven voor de fysiotherapeut
(pp. 15). Houten: Bohn Stafleu van Loghum.
Verhagen, A.P., Ostelo, R.W.J.G. & Rademaker, A. (2012). Is de p-waarde wel zo significant? In RWGJ
Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap; lesbrieven voor de fysiotherapeut
(pp. 15). Houten: Bohn Stafleu van Loghum.
Verhagen, A.P. & Vet, H.C.W. de (2012). Methodologie van diagnostische tests I: ver-van-mijn-bed
show? In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap; lesbrieven voor
de fysiotherapeut (pp. 17). Houten: Bohn Stafleu van Loghum.
Verhagen, A.P., Bie, R.A. de & Vet, H.C.W. de (2012). Methodologie van diagnostische tests II:
Statistiek of data-massage? In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in
Wetenschap; lesbrieven voor de fysiotherapeut (pp. 18). Houten: Bohn Stafleu van Loghum.
Erasmus MC – Research Annual Report 2012
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Vet, H.C.W. de, Logghe, I.H.J. & Verhagen, A.P. (2012). Systematische reviews van effectonderzoek:
doel en opzet. In RWGJ Ostelo, AP Verhagen & HCW de Vet (Eds.), Onderwijs in Wetenschap;
lesbrieven voor de fysiotherapeut (pp. 25). Houten: Bohn Stafleu van Loggum.
Book Editorship
Bindels, P.J.E. & Kneepkens, C.M.F. (Eds.). (2012). Kindergeneeskunde; Tweede, geheel herziene druk.
Houten: Bohn Stafleu van Loghum.
Ostelo, R.W.J.G., Verhagen, A.P. & Vet, H.C.W. de (Eds.). (2012). Onderwijs in Wetenschap; lesbrieven
voor de fysiotherapeut. Houten: Bohn Stafleu van Loghum.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-03-30-01 - Implementation of diagnostic and interventional imaging
technology
Programme (brief description)
The research program focuses on the implementation of new techniques used for diagnostic and
interventional imaging technology. Specific topics of interest within the program are Magnetic
Resonance (MR) technology (including interventional MRI), Multidetector Spiral Computed
Tomography (MSCT), and interventional radiology. Projects involve high-speed MR-angiography
of coronary/carotid arteries and veins, MRI of organ perfusion (e.g. brain perfusion in stroke,
perfusion in transplant organs), real-time imaging of catheter and needle manipulations,
MRI-temperature mapping (to monitor thermo-ablative treatment of localized heat-induced gene
therapy), and percutaneous treatment of vascular disease. Emphasis is placed on carotid artery
stenting, percutaneous treatment of aortic aneurysmal disease in elective and acute situations,
creation of Transjugular Intrahepatic Portosystemic Shunts (TIPS), thermo-ablation with laser or
focused percutaneous ultrasound, and non-invasive coronary angiography with MSCT.
A parallel line of investigation implements molecular imaging techniques developed in EMC
NIHES-03-30-03. Although we principally use MRI (3T) imaging techniques, the potential exists
to use MSCT for molecular imaging for projects for which this would be advantageous. Possible
future directions include quantification of tumor perfusion and angiogenesis, heat-induced local
drug delivery or gene therapy, and/or applying heat- sensitive contrast agents.
There is extensive collaboration with clinical groups within Erasmus MC, including the
Departments of Internal Medicine, Pediatrics, Vascular Surgery, Cardiology, Neurology, and
Surgical Oncology ¿ and with Erasmus MC basic science groups ¿ including the Department of
Experimental Cardiology/Thorax Center and the Department of Medical Informatics.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
cardiology
0,63
0,63
epidemiology
0,09
0,09
pediatric psychiatry
0,03
0,03
pediatrics-cardiology
0,1
0,1
pediatrics-IC/N
0,2
0,2
pediatrics-other
0,18
0,18
pediatrics-pulmonology
0,58
0,58
radiology
9,76
0,62
11,57
0,62
Total
0
0,75
11,13
0,75
12,94
T1
T2
T3
Ttot
4
0
0
4
IS
106
FS
OP
6
0
Thesis
Elias-Smale, S.E. (2012, januari 18). Coronary artery calcification and cardiovascular risk prediction.
EUR. Prom./coprom.: Prof. Dr. J.C.M. Witteman & Prof. Dr. A. van der Lugt.
Loeve, M. (2012, januari 20). Chest computed tomography in early and advanced cystic fibrosis lung
disease. EUR (219 pag.). Prom./coprom.: Prof. Dr. H.A.W.M. Tiddens & Prof. Dr. G.P. Krestin.
Monye, C. de (2012, juni 13). CT angiography in ischemic stroke. EUR (200 pag.). Prom./coprom.: Prof.
Dr. A. van der Lugt & Prof. Dr. D.W.J. Dippel.
Poels, M.M.F. (2012, december 19). Population imaging of cerebral small vessel disease. EUR (240
pag.). Prom./coprom.: Prof. Dr. M.M.B. Breteler, Prof. Dr. A. van der Lugt & Dr. M.W. Vernooij.
Erasmus MC – Research Annual Report 2012
Ptot
116
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Article/Letter to the editor
Agricola, R., Bessems, J.H.J.M., Ginai, A.Z., Heijboer, M.P., Heijden, R.A. van der, Verhaar, J.A.N.,
Weinans, H.H. & Waarsing, J.H. (2012). The Development of Cam-Type Deformity in Adolescent and
Young Male Soccer Players. American Journal of Sports Medicine, 40(5), 1099-1106.
Aldrovandi, A, Cademartiri, F., Arduini, D, Lina, D, Ugo, F, Maffei, E., Menozzi, A., Martini, C, Palumbo,
A, Bontardelli, F, Gherli, T, Ruffini, L & Ardissino, D. (2012). Computed Tomography Coronary
Angiography in Patients With Acute Myocardial Infarction Without Significant Coronary Stenosis.
Circulation, 126(25), 3000-3007.
Amin, R., Charron, M., Grinblat, L., Shammas, A., Grasemann, H., Gonzalez Graniel, K., Ciet, P.,
Tiddens, H. & Ratjen, F. (2012). Cystic Fibrosis: Detecting Changes in Airway Inflammation with FDG
PET/CT. Radiology, 264(3), 868-875.
Barral, S, Fernandez-Cadenas, I, Bis, JC, Montaner, J, Ikram, M.A., Launer, L.J., Fornage, M, Schmidt,
H., Brickman, AM, Seshadri, S & Mayeux, R. (2012). No association of ALOX5AP polymorphisms with
risk of MRI-defined brain infarcts. Neurobiology of Aging, 33(3).
Bastos Goncalves, F.M., Jairam, A, Voute, M.T., Moelker, A.D., Rouwet, E.V., Raa, S. ten, Hendriks, J.M.
& Verhagen, H.J.M. (2012). Clinical outcome and morphologic analysis after endovascular aneurysm
repair using the Excluder endograft. Journal of Vascular Surgery, 56(4), 920-928.
Bis, JC, DeCarli, C., Smith, AV, Lijn, F. van der, Crivello, F, Fornage, M, Debette, S, Shulman, JM,
Schmidt, H., Srikanth, V, Schuur, M., Yu, L, Choi, SH, Sigurdsson, S, Verhaaren, B.F.J., DeStefano, AL,
Lambert, JC, Jack, CR, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, CA, Fleischman, D, Zijdenbos, A.,
Heijer, T. den, Mazoyer, B, Coker, LH, Enzinger, C, Danoy, P, Amin, N., Arfanakis, K, Buchem, M.A. van,
Bruijn, R.F.A.G. de, Beiser, A, Dufouil, C., Huang, JB, Cavalieri, M, Thomson, R, Niessen, W.J., Chibnik,
LB, Gislason, GK, Hofman, A., Pikula, A, Amouyel, P, Freeman, KB, Phan, TG, Oostra, B.A., Stein, JL,
Medland, SE, Vasquez, AA, Hibar, DP, Wright, MJ, Franke, B., Martin, NG, Thompson, PM, Nalls, MA,
Uitterlinden, A.G., Au, R., Elbaz, A., Beare, RJ, Swieten, J.C. van, Lopez, OL, Harris, T.B., Chouraki, V,
Breteler, M.M.B., Jager, PL De, Becker, JT, Vernooij, M.W., Knopman, D., Fazekas, F., Wolf, PA, Lugt, A.
van der, Gudnason, V, Longstreth, W.T., Brown, M.A., Bennett, DA, Duijn, C.M. van, Mosley, TH,
Schmidt, R., Tzourio, C., Launer, L.J., Ikram, M.A. & Seshadri, S (2012). Common variants at 12q14 and
12q24 are associated with hippocampal volume. Nature Genetics, 44(5), 545-551.
Bos, D., Vernooij, M.W., Elias-Smale, S.E., Verhaaren, B.F.J., Vrooman, H.A., Hofman, A., Niessen,
W.J., Witteman, J.C.M., Lugt, A. van der & Ikram, M.A. (2012). Atherosclerotic calcification relates to
cognitive function and to brain changes on magnetic resonance imaging. Alzheimers & Dementia, 8,
s104-s111.
Bos, D., Rijk, M.J.M. van der, Geeraedts, T.E.A., Hofman, A., Krestin, G.P., Witteman, J.C.M., Lugt, A.
van der, Ikram, M.A. & Vernooij, M.W. (2012). Intracranial Carotid Artery Atherosclerosis Prevalence
and Risk Factors in the General Population. Stroke, 43(7), 1878-1884.
Bouwhuijsen, Q.J.A. van den, Vernooij, M.W., Hofman, A., Krestin, G.P., Lugt, A. van der & Witteman,
J.C.M. (2012). Determinants of magnetic resonance imaging detected carotid plaque components: the
Rotterdam Study. European Heart Journal, 33(2), 221-229.
Cademartiri, F. & Maffei, E. (2012). IMAGING CT coronary angiography in low-risk, acute chest pain.
Nature Reviews Cardiology, 9(11), 615-616.
Cho, I, Chang, HJ, Sung, JM, Pencina, MJ, Lin, FY, Dunning, A.M., Achenbach, S, Al-Mallah, M, Berman,
DS, Budoff, MJ, Callister, TQ, Chow, BJW, Delago, A, Hadamitzky, M, Hausleiter, J, Maffei, E.,
Cademartiri, F., Kaufmann, P., Shaw, LJ, Raff, GL, Chinnaiyan, KM, Villines, TC, Cheng, V, Nasir, K,
Gomez, M & Min, JK (2012). Coronary Computed Tomographic Angiography and Risk of All-Cause
Mortality and Nonfatal Myocardial Infarction in Subjects Without Chest Pain Syndrome From the
Erasmus MC – Research Annual Report 2012
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CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International
Multicenter Registry). Circulation, 126(3), 304-313.
Dharampal, A.S., Papadopoulou, S.L., Rossi, A., Weustink, A.C., Mollet, N.R.A., Meijboom, W.B.,
Neefjes, L.A.E., Nieman, K., Boersma, E., Feyter, P.J. de & Krestin, G.P. (2012). Computed tomography
coronary angiography accuracy in women and men at low to intermediate risk of coronary artery
disease. European Radiology, 22(11), 2415-2423.
Driessen, C., Veelen, M.L.C. van, Lequin, M.H., Joosten, K.F.M. & Mathijssen, I.M.J. (2012). Nocturnal
ultrasound measurements of optic nerve sheath diameter correlate with intracranial pressure in children
with craniosynostosis. Plastic and Reconstructive Surgery, 130, 448e-451e.
Dudink, J., Counsell, S.J., Lequin, M.H. & Govaert, P. (2012). DTI reveals network injury in perinatal
stroke. Archives of Disease in Childhood. Fetal and Neonatal Edition, 97, F362-F364.
Ebbink, B.J., Aarsen, F.K., Gelder, C.M. van, Hout, J.M.P. van den, Weisglas-Kuperus, N., Jaeken, J.,
Lequin, M.H., Arts, W.F.M. & Ploeg, A.T. van der (2012). Cognitive outcome of patients with classic
infantile Pompe disease receiving enzyme therapy. Neurology, 78, 1512-1518.
Engelen, A. van, Niessen, W.J., Klein, S., Groen, H.C., Verhagen, H.J.M., Wentzel, J.J., Lugt, A. van der
& Bruijne, M. de (2012). Multi-feature-based plaque characterization in ex vivo MRI trained by
registration to 3D histology. Physics in Medicine and Biology, 57(1), 241-256.
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Erasmus MC – Research Annual Report 2012
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EMC NIHES-03-30-02 - Assessment of diagnostic and interventional imaging technology
Programme (brief description)
The research program focuses on the assessment of diagnostic imaging technology and
image-guided therapies. The assessment includes clinical efficacy, patient outcomes, and
costs-effectiveness. There is a special interest in the assessment of new imaging technology for
cardiovascular disease, including such techniques as magnetic resonance angiography,
computed tomography angiography, imaging of vulnerable plaque, and molecular imaging. The
research methods employed are from clinical epidemiology, decision sciences, and medical
technology assessment. The methodological research of the group focuses on developing the
methods and study design for evaluating diagnostic imaging technology. The long-term goal of
the program is to provide relevant information for implementing evidence-based clinical services.
The program is a collaborative effort between the Depts of Radiology and Epidemiology &
Biostatistics.
Key Figures
Department
Sp1
epidemiology
0,06
radiology
1,1
radiotherapy
0,38
Total
1,54
Sp2
Sp3
Sp4
SpTot
T1
T2
T3
Ttot
IS
FS
OP
Ptot
2
0
0
2
13
2
0
17
0,06
0,65
0,65
1,75
0
0
1,81
Thesis
Genders, T.S.S. (2012, juni 29). Diagnostic imaging stragegies for patients with suspected coronary
artery disease. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. K. Nieman.
Grootenboer, N. (2012, november 07). Gender differences in presentation of disease and clinical
outcome after vascular surgery. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. M.R.H.M. van
Sambeek.
Article/Letter to the editor
Fakhry, F., Luijtgaarden, K.M. van de, Bax, L., Hoed, P.T. den, Hunink, M.G.M., Rouwet, E.V. & Spronk,
S. (2012). Supervised walking therapy in patients with intermittent claudication. Journal of Vascular
Surgery, 56(4), 1132-1142.
Ferket, B.S., Kempen, B.J.H. van, Heeringa, J., Spronk, S., Fleischmann, K.E., Nijhuis, RLG, Hofman, A.,
Steyerberg, E.W. & Hunink, M.G.M. (2012). Personalized Prediction of Lifetime Benefits with Statin
Therapy for Asymptomatic Individuals: A Modeling Study. PLoS Medicine, 9(12).
Ferket, B.S., Grootenboer, N., Colkesen, EB, Visser, J.J., Sambeek, M.R.H.M. van, Spronk, S.,
Steyerberg, E.W. & Hunink, M.G.M. (2012). Systematic review of guidelines on abdominal aortic
aneurysm screening. Journal of Vascular Surgery, 55(5), 1296-1304.
Ferket, B.S., Spronk, S., Colkesen, EB & Hunink, M.G.M. (2012). Systematic Review of Guidelines on
Peripheral Artery Disease Screening. American Journal of Medicine, 125(2), 198-+.
Genders, T.S.S., Spronk, S., Stijnen, T., Steyerberg, E.W., Lesaffre, E.M.E.H. & Hunink, M.G.M. (2012).
Methods for Calculating Sensitivity and Specificity of Clustered Data: A Tutorial. Radiology, 265(3),
910-916.
Genders, T.S.S., Steyerberg, E.W., Nieman, K., Galema, T.W., Mollet, N.R., Feyter, P.J. de, Krestin,
G.P., Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J.,
Erasmus MC – Research Annual Report 2012
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Goetschalckx, K, Cademartiri, F., Maffei, E., Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B,
Fornaro, J, Feuchtner, G, Zordo, T De, Auer, T, Plank, F, Friedrich, G, Pugliese, F., Petersen, SE, Davies,
LC, Schoepf, UJ, Rowe, GW, Mieghem, C.A.G. van, Driessche, L van, Sinitsyn, V, Gopalan, D., Nikolaou,
K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B., Becker, D,
Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E., Laule, M & Hunink, M.G.M. (2012).
Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of
existing cohorts. British Medical Journal, 344.
Jong, M.C. de, Genders, T.S.S., Geuns, R.J.M. van, Moelker, A. & Hunink, M.G.M. (2012). Diagnostic
performance of stress myocardial perfusion imaging for coronary artery disease: a systematic review
and meta-analysis. European Radiology, 22(9), 1881-1895.
Kempen, B.J.H. van, Ferket, B.S., Hofman, A., Spronk, S., Steyerberg, E.W. & Hunink, M.G.M. (2012).
Do Different Methods of Modeling Statin Treatment Effectiveness Influence the Optimal Decision?
Medical Decision Making, 32(3), 507-516.
Kempen, B.J.H. van, Ferket, B.S., Hofman, A., Steyerberg, E.W., Colkesen, EB, Boekholdt, S.M.,
Wareham, NJ, Khaw, KT & Hunink, M.G.M. (2012). Validation of a model to investigate the effects of
modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the Rotterdam ischemic
heart disease and stroke computer simulation (RISC) model. BMC Medicine, 10.
Koller, M.T., Leening, M.J.G., Wolbers, M, Steyerberg, E.W., Hunink, M.G.M., Schoop, R, Hofman, A.,
Bucher, HC, Psaty, B.M., Lloyd-Jones, DM & Witteman, J.C.M. (2012). Development and Validation of a
Coronary Risk Prediction Model for Older US and European Persons in the Cardiovascular Health Study
and the Rotterdam Study. Annals of Internal Medicine, 157(6), 389-397.
Krestin, G.P., Grenier, PA, Hricak, H., Jackson, VP, Khong, PL, Miller, JC, Muellner, A, Schwaiger, M &
Thrall, JH (2012). Integrated diagnostics: proceedings from the 9th biennial symposium of the
International Society for Strategic Studies in Radiology. European Radiology, 22(11), 2283-2294.
Liem, Y.S., Wong, J.B., Winkelmayer, WC, Weimar, W., Wetzels, J.F.M., Charro, F.T.M. de, Kaandorp,
G.C., Stijnen, T. & Hunink, M.G.M. (2012). Quantifying the benefit of early living-donor renal
transplantation with a simulation model of the Dutch renal replacement therapy population. Nephrology
Dialysis Transplantation, 27(1), 429-434.
Osnabrugge, R.L.J., Head, S.J., Genders, T.S.S., Mieghem, N.M.D.A. van, Jaegere, P.P.T. de, Boon,
R.M.A. van der, Kerkvliet, J.M., Kalesan, B, Bogers, A.J.J.C., Kappetein, A.P. & Hunink, M.G.M. (2012).
Costs of Transcatheter Versus Surgical Aortic Valve Replacement in Intermediate-Risk Patients. Annals
of Thoracic Surgery, 94(6), 1954-1960.
Stel, H.F. van, Busschbach, J.J. van, Hunink, M.G.M. & Buskens, E. (2012). Impact of Secondary
Cardiovascular Events on Health Status. Value in Health, 15(1), 175-182.
Vlaardingerbroek, H., Veldhorst, M.A.B., Spronk, S., Akker, C.H.P. van den & Goudoever, J.B. van
(2012). Parental lipid administration to very-low-birth-weight infants - early introduction of lipids and
use of new lipid emulsions: a systematic review and meta-analysis. American Journal of Clinical
Nutrition, 96, 255-268.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-03-30-03 - Development of acquisition and processing techniques for
diagnostic imaging
Programme (brief description)
The general goal of this research program is to investigate and validate new diagnostic and
therapeutic imaging techniques for both Computed Tomography (CT) and Magnetic Resonance
Imaging (MRI). We focus on image acquisition, processing and segmentation of three (or higher)
dimensional image data in order to be able to enhance patient care.
The main research focuses are the improvement of existing and development new computerized
techniques for the segmentation of high-dimensional diagnostic images. Specific goals are (a) to
increase the outcome of image segmentation techniques, (b) to develop new ways of visualizing
high-dimensional data sets by combining existing techniques (surface and volume rendering)
with newly developed methods (virtual reality), and (c) to improve user-interfaces and develop
automated procedures to assist the end-user with the post-processing, segmentation and
visualization of radiological image data. Furthermore, image registration, data fusion and
measurements in diagnostic images will be developed and validated.
We are also interested in optimizing acquisition protocols so that region-of-interest imaging
makes use of the maximum capabilities of our imaging systems. This will benefit both diagnosis
and therapeutical monitoring tasks. The initial target is enhanced direct visualization of the
epicardial coronary anatomy, by which we can establish the presence, site, severity, and/or
status of coronary atherosclerotic disease. Further targets are assessment of ventricular function
and characterization of atherosclerotic plaque composition. We will than use the optimized
protocols to investigate the diagnostic possibilities and diagnostic accuracy of MR cardiac and
coronary imaging and to determine the possible clinical indications for MR imaging of both native
coronary artery disease and coronary bypass disease.
Molecular Imaging is an area demanding international attention. Acquisition of information on
the cellular and molecular level and subsequent analysis is expected to have a profound impact
on the diagnosis, monitoring and treatment of diseases that have the potential of being redefined
in terms of their characteristics genetic or molecular abnormalities. We are optimizing our
imaging systems (with an emphasis on MRI) to provide near-cellular resolution and expect to
move into animal studies soon.
Key Figures
Department
Sp1
Sp2
Sp4
SpTot
0,18
1,02
15,54
medical informatics
6,19
nuclear medicine
0,03
radiology
9,19
8,62
0,38
1,72
19,91
15,41
16,77
0,56
2,74
35,48
Total
8,15
Sp3
T1
T2
T3
Ttot
IS
FS
OP
4
0
0
4
41
1
1
Ptot
0,03
47
Thesis
Baka, N. (2012, november 16). Anatomical shape and motion reconstruction from Sparse Image Data.
EUR (161 pag.). Prom./coprom.: Prof. Dr. W.J. Niessen, B.P.F. Lelieveldt & Ir. M. de Bruijne.
Dirks, M. (2012, februari 17). Intravenous thormbolysis for acute ischaemic stroke. EUR.
Prom./coprom.: Prof. Dr. D.W.J. Dippel & Prof. Dr. W.J. Niessen.
Ruggiero, A. (2012, november 02). The molecular imaging suite. EUR (287 pag.). Prom./coprom.: Prof.
Dr. G.P. Krestin, H. Hricak & Dr. M.R. Bernsen.
Vukadinovic, D. (2012, mei 24). Automated quantification of atherosclerosis in CTA of Carotid Arteries.
EUR (105 pag.). Prom./coprom.: Prof. Dr. W.J. Niessen & Dr. T. van Walsum.
Erasmus MC – Research Annual Report 2012
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Article/Letter to the editor
Ampt, KAM, Aspers, RLEG, Dvortsak, P, Werf, R.M. van der, Wijmenga, SS & Jaeger, M (2012).
Determination of size and sign of hetero-nuclear coupling constants from 2D F-19-C-13 correlation
spectra. Journal of Magnetic Resonance, 215, 27-33.
Baka, N., Bruijne, M. de, Walsum, T. van, Kaptein, BL, Giphart, JE, Schaap, M., Niessen, W.J. &
Lelieveldt, B.P.F. (2012). Statistical Shape Model-Based Femur Kinematics From Biplane Fluoroscopy.
IEEE Transactions on Medical Imaging, 31(8), 1573-1583.
Bis, JC, DeCarli, C., Smith, AV, Lijn, F. van der, Crivello, F, Fornage, M, Debette, S, Shulman, JM,
Schmidt, H., Srikanth, V, Schuur, M., Yu, L, Choi, SH, Sigurdsson, S, Verhaaren, B.F.J., DeStefano, AL,
Lambert, JC, Jack, CR, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, CA, Fleischman, D, Zijdenbos, A.,
Heijer, T. den, Mazoyer, B, Coker, LH, Enzinger, C, Danoy, P, Amin, N., Arfanakis, K, Buchem, M.A. van,
Bruijn, R.F.A.G. de, Beiser, A, Dufouil, C., Huang, JB, Cavalieri, M, Thomson, R, Niessen, W.J., Chibnik,
LB, Gislason, GK, Hofman, A., Pikula, A, Amouyel, P, Freeman, KB, Phan, TG, Oostra, B.A., Stein, JL,
Medland, SE, Vasquez, AA, Hibar, DP, Wright, MJ, Franke, B., Martin, NG, Thompson, PM, Nalls, MA,
Uitterlinden, A.G., Au, R., Elbaz, A., Beare, RJ, Swieten, J.C. van, Lopez, OL, Harris, T.B., Chouraki, V,
Breteler, M.M.B., Jager, PL De, Becker, JT, Vernooij, M.W., Knopman, D., Fazekas, F., Wolf, PA, Lugt, A.
van der, Gudnason, V, Longstreth, W.T., Brown, M.A., Bennett, DA, Duijn, C.M. van, Mosley, TH,
Schmidt, R., Tzourio, C., Launer, L.J., Ikram, M.A. & Seshadri, S (2012). Common variants at 12q14 and
12q24 are associated with hippocampal volume. Nature Genetics, 44(5), 545-551.
Bos, D., Vernooij, M.W., Elias-Smale, S.E., Verhaaren, B.F.J., Vrooman, H.A., Hofman, A., Niessen,
W.J., Witteman, J.C.M., Lugt, A. van der & Ikram, M.A. (2012). Atherosclerotic calcification relates to
cognitive function and to brain changes on magnetic resonance imaging. Alzheimers & Dementia, 8,
s104-s111.
Buul, G.M. van, Villafuertes, E, Bos, P.K., Waarsing, J.H., Kops, N., Narcisi, R., Weinans, H.H., Verhaar,
J.A.N., Bernsen, M.R. & Osch, G.J.V.M. van (2012). Mesenchymal stem cells secrete factors that inhibit
inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture.
Osteoarthritis and Cartilage, 20(10), 1186-1196.
Engelen, A. van, Niessen, W.J., Klein, S., Groen, H.C., Verhagen, H.J.M., Wentzel, J.J., Lugt, A. van der
& Bruijne, M. de (2012). Multi-feature-based plaque characterization in ex vivo MRI trained by
registration to 3D histology. Physics in Medicine and Biology, 57(1), 241-256.
Gils, M.J. van, Vukadinovic, D., Dijk, A.C. van, Dippel, D.W.J., Niessen, W.J. & Lugt, A. van der (2012).
Carotid Atherosclerotic Plaque Progression and Change in Plaque Composition Over Time: A 5-Year
Follow-Up Study Using Serial CT Angiography. American Journal of Neuroradiology, 33(7), 1267-1273.
Gorbunova, V, Sporring, J, Lo, M., Loeve, M., Tiddens, H.A.W.M., Nielsen, M, Dirksen, A. & Bruijne, M.
de (2012). Mass preserving image registration for lung CT. Medical Image Analysis, 16, 786-795.
Guenoun, J., Koning, G.A., Doeswijk, G.N., Bosman, L., Wielopolski, P.A., Krestin, G.P. & Bernsen, M.R.
(2012). Cationic Gd-DTPA Liposomes for Highly Efficient Labeling of Mesenchymal Stem Cells and Cell
Tracking With MRI. Cell Transplantation, 21(1), 191-205.
Gupta, V., Kirisli, H.A., Hendriks, EA, Geest, R.J. van der, Giessen, M. van der, Niessen, W., Reiber,
J.H.C. & Lelieveldt, B.P.F. (2012). Cardiac MR perfusion image processing techniques: A survey. Medical
Image Analysis, 16(4), 767-785.
Heijer, T. den, Lijn, F. van der, Vernooij, M.W., Groot, M. de, Koudstaal, P.J., Lugt, A. van der, Krestin,
G.P., Hofman, A., Niessen, W.J. & Breteler, M.M.B. (2012). Structural and diffusion MRI measures of the
hippocampus and memory performance. Neuroimage, 63(4), 1782-1789.
Heijer, T. den, Lijn, F. van der, Ikram, M.A., Koudstaal, P.J., Lugt, A. van der, Krestin, G.P., Vrooman,
H.A., Hofman, A., Niessen, W.J. & Breteler, M.M.B. (2012). Vascular risk factors, apolipoprotein E, and
Erasmus MC – Research Annual Report 2012
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hippocampal decline on magnetic resonance imaging over a 10-year follow-up. Alzheimers
Dementia, 8(5), 417-425.
&
Hoogendam, Y.Y., Geest, J.N. van der, Lijn, F. van der, Lugt, A. van der, Niessen, W.J., Krestin, G.P.,
Hofman, A., Vernooij, M.W., Breteler, M.M.B. & Ikram, M.A. (2012). Determinants of cerebellar and
cerebral volume in the general elderly population. Neurobiology of Aging, 33(12), 2774-2781.
Ikram, M.A., Fornage, M, Smith, AV, Seshadri, S, Schmidt, R., Debette, S, Vrooman, H.A., Sigurdsson,
S, Ropele, S, Taal, H.R., Mook-Kanamori, D.O., Coker, LH, Longstreth, W.T., Niessen, W.J., DeStefano,
AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Rivadeneira Ramirez, F., Uitterlinden, A.G.,
Knopman, DS, Hartikainen, AL, Pennell, CE, Thiering, E, Steegers, E.A.P., Hakonarson, H, Heinrich, J.,
Palmer, LJ, Jarvelin, MR, McCarthy, MI, Grant, S.F.A., Pourcain, B St, Timpson, NJ, Smith, G.D., Sovio,
U, Nalls, MA, Au, R., Hofman, A., Gudnason, H, Lugt, A. van der, Harris, T.B., Meeks, WM, Vernooij,
M.W., Buchem, M.A. van, Catellier, D, Jaddoe, V.W.V.K., Gudnason, V, Windham, BG, Wolf, PA, Duijn,
C.M. van, Mosley, TH, Schmidt, H., Launer, L.J., Breteler, M.M.B., DeCarli, C., Adair, LS, Ang, W, Atalay,
M, vanBeijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Davis, OSP, Elliott, P., Flexeder, C,
Frayling, T, Gaillard, R., Groen-Blokhuis, M, Goh, LK, Haworth, CMA, Hadley, D, Hedebrand, J, Hinney,
A, Hirschhorn, JN, Holloway, JW, Holst, C, Hottenga, J.J., Horikoshi, M, Huikari, V, Hypponen, E,
Kilpelainen, TO, Kirin, M, Kowgier, M, Lakka, HM, Lange, LA, Lawlor, DA, Lehtimaki, T, Lewin, A,
Lindgren, C, Lindi, V, Maggi, R, Marsh, J, Middeldorp, C, Millwood, I, Murray, JC, Nivard, M, Nohr, EA,
Ntalla, I, Oken, E, Panoutsopoulou, K., Pararajasingham, J, Rodriguez, A., Salem, RM, Sebert, S,
Siitonen, N, Strachan, DP, Teo, YY, Valcarcel, B, Willemsen, G, Zeggini, E, Boomsma, D.I., Cooper, C.,
Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, E.R., Price, TS, Power,
C, Raitakari, OT, Saw, SM, Scherag, A, Simell, O, Sorensen, T.I.A. & Wilson, JF (2012). Common
variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-+.
Isola, A.A., Metz, C.T., Schaap, M., Klein, S., Grass, M & Niessen, W.J. (2012). Cardiac motion-corrected
iterative cone-beam CT reconstruction using a semi-automatic minimum cost path-based coronary
centerline extraction. Computerized Medical Imaging and Graphics, 36(3), 215-226.
Khmelinskii, A, Groen, H.C., Baiker, M., Jong, M. de & Lelieveldt, B.P.F. (2012). Segmentation and
Visual Analysis of Whole-Body Mouse Skeleton microSPECT. PLoS One, 7(11).
Koppelmans, V., Ruiter, M.B. de, Lijn, F. van der, Boogerd, W., Seynaeve, C., Lugt, A. van der,
Vrooman, H.A., Niessen, W.J., Breteler, M.M.B. & Schagen, SB (2012). Global and focal brain volume in
long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Research and
Treatment, 132(3), 1099-1106.
Kotek, G., Tiel, S.T. van, Wielopolski, P.A., Houston, G.C., Krestin, G.P. & Bernsen, M.R. (2012). Cell
quantification: evolution of compartmentalization and distribution of iron-oxide particles and labeled
cells. Contrast Media & Molecular Imaging, 7(2), 195-203.
Krestin, G.P., Grenier, PA, Hricak, H., Jackson, VP, Khong, PL, Miller, JC, Muellner, A, Schwaiger, M &
Thrall, JH (2012). Integrated diagnostics: proceedings from the 9th biennial symposium of the
International Society for Strategic Studies in Radiology. European Radiology, 22(11), 2283-2294.
Lijn, F. van der, Bruijne, M. de, Klein, S., Heijer, T. den, Hoogendam, Y.Y., Lugt, A. van der, Breteler,
M.M.B. & Niessen, W.J. (2012). Automated Brain Structure Segmentation Based on Atlas Registration
and Appearance Models. IEEE Transactions on Medical Imaging, 31(2), 276-286.
Lijn, F. van der, Verhaaren, B.F.J., Ikram, M.A., Klein, S., Bruijne, M. de, Vrooman, H.A., Vernooij,
M.W., Hammers, A, Rueckert, D, Lugt, A. van der, Breteler, M.M.B. & Niessen, W.J. (2012). Automated
measurement of local white matter lesion volume. Neuroimage, 59(4), 3901-3908.
Liu, F., Lijn, F. van der, Schurmann, C, Zhu, G., Chakravarty, MM, Hysi, PG, Wollstein, A.D., Lao Grueso,
O., Bruijne, M. de, Ikram, M.A., Lugt, A. van der, Rivadeneira, F., Uitterlinden, A.G., Hofman, A.,
Niessen, W.J., Homuth, G., Zubicaray, G de, McMahon, KL, Thompson, PM, Daboul, A, Puls, R,
Hegenscheid, K, Bevan, L, Pausova, Z, Medland, SE, Montgomery, GW, Wright, MJ, Wicking, C,
Erasmus MC – Research Annual Report 2012
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Boehringer, S, Spector, T.D., Paus, T, Martin, NG, Biffar, R & Kayser, M. (2012). A Genome-Wide
Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLoS Genetics, 8(9).
Lo, P, Ginneken, B.T.J. van, Reinhardt, JM, Yavarna, T, Jong, P.A. de, Irving, B, Fetita, C, Ortner, M,
Pinho, R, Sijbers, J., Feuerstein, M, Fabijanska, A, Bauer, C, Beichel, R, Mendoza, CS, Wiemker, R, Lee,
J. van der, Reeves, AP, Born, S, Weinheimer, O, Rikxoort, EM van, Tschirren, J, Mori, K, Odry, B,
Naidich, DP, Hartmann, I., Hoffman, EA, Prokop, M, Pedersen, J.H. & Bruijne, M. de (2012). Extraction
of Airways From CT (EXACT'09). IEEE Transactions on Medical Imaging, 31(11), 2093-2107.
Loeve, M., Hop, W.C.J., Bruijne, M. de, Hal, P.T.W. van, Robinson, P., Aitken, ML, Dodd, J.D. & Tiddens,
H.A.W.M. (2012). Chest Computed Tomography Scores Are Predictive of Survival in Patients with Cystic
Fibrosis Awaiting Lung Transplantation. American Journal of Respiratory and Critical Care Medicine,
185(10), 1096-1103.
Loeve, M., Bruijne, M. de, Hartmann, I.J.C., Straten, M. van, Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Three-Section Expiratory CT: Insufficient for Trapped Air Assessment in Patients with Cystic Fibrosis?
Radiology, 262(3), 969-976.
Medici, M., Ikram, M.A., Lijn, F. van der, Heijer, T. den, Vernooij, M.W., Hofman, A., Niessen, W.J.,
Visser, T.J., Breteler, M.M.B. & Peeters, R.P. (2012). The Thyroid Hormone Receptor Alpha Locus and
White Matter Lesions: A Role for the Clock Gene REV-ERB alpha. Thyroid, 22(11), 1181-1186.
Melis, M.L., Valkema, R., Krenning, E.P. & Jong, M. de (2012). Reduction of Renal Uptake of
Radiolabeled Octreotate by Amifostine Coadministration. Journal of Nuclear Medicine, 53(5), 749-753.
Mendrik, A.M., Vonken, EPA, Kort, GAP de, Ginneken, B.T.J. van, Smit, E.J., Viergever, M.A. & Prokop,
M (2012). Improved Arterial Visualization in Cerebral CT Perfusion-Derived Arteriograms Compared
with Standard CT Angiography: A Visual Assessment Study. American Journal of Neuroradiology,
33(11), 2171-2177.
Metz, C.T., Baka, N., Kirisli, H.A., Schaap, M., Klein, S., Neefjes, L.A.E., Mollet, N.R., Lelieveldt, B,
Bruijne, M. de, Niessen, W.J. & Walsum, T. van (2012). Regression-Based Cardiac Motion Prediction
From Single-Phase CTA. IEEE Transactions on Medical Imaging, 31(6), 1311-1325.
Nout, E., Bezooijen, J.S. van, Koudstaal, M.J., Veenland, J.F., Hop, W.C.J., Wolvius, E.B. & Wal, K.G.H.
van der (2012). Orbital change following Le Fort III advancement in syndromic craniosynostosis:
Quantitative evaluation of orbital volume, infra-orbital rim and globe position. Journal of
Cranio-Maxillofacial Surgery, 40(3), 223-228.
Nout, E., Bannink, N., Koudstaal, M.J., Veenland, J.F., Joosten, K.F.M., Poublon, R.M.L., Wal, K.G.H.
van der, Mathijssen, I.M.J. & Wolvius, E.B. (2012). Upper airway changes in syndromic craniosynostosis
patients following midface or monobloc advancement: Correlation between volume changes and
respiratory outcome. Journal of Cranio-Maxillofacial Surgery, 40(3), 209-214.
Plenge, E., Poot, D.H.J., Bernsen, M.R., Kotek, G., Houston, G, Wielopolski, P.A., Weerd, L van der,
Niessen, W.J. & Meijering, H.W. (2012). Super-resolution methods in MRI: Can they improve the
trade-off between resolution, signal-to-noise ratio, and acquisition time? Magnetic Resonance in
Medicine, 68(6), 1983-1993.
Poels, M.M.F., Ikram, M.A., Lugt, A. van der, Hofman, A., Niessen, W.J., Krestin, G.P., Breteler, M.M.B.
& Vernooij, M.W. (2012). Cerebral microbleeds are associated with worse cognitive function The
Rotterdam Scan Study. Neurology, 78(5), 326-333.
Ruggiero, A., Thorek, DLJ, Guenoun, J., Krestin, G.P. & Bernsen, M.R. (2012). Cell tracking in cardiac
repair: what to image and how to image. European Radiology, 22(1), 189-204.
Erasmus MC – Research Annual Report 2012
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Schiavon, G., Ruggiero, A., Schoffski, P, Holt, B. van der, Bekers, DJ, Eechoute, K., Vandecaveye, V,
Krestin, G.P., Verweij, J., Sleijfer, S. & Mathijssen, R.H.J. (2012). Tumor Volume as an Alternative
Response Measurement for Imatinib Treated GIST Patients. PLoS One, 7(11).
Shaker, SB, Dirksen, A., Lo, P, Skovgaard, LT, Bruijne, M. de & Pedersen, J.H. (2012). Factors
influencing the decline in lung density in a Danish lung cancer screening cohort. European Respiratory
Journal, 40(5), 1142-1148.
Smal, I., Carranza Herrezuelo, N., Klein, S., Wielopolski, P.A., Moelker, A., Springeling, T., Bernsen,
M.R., Niessen, W. & Meijering, H.W. (2012). Reversible jump MCMC methods for fully automatic motion
analysis in tagged MRI. Medical Image Analysis, 16(1), 301-324.
Tang, H., Walsum, T. van, Onkelen, R.S. van, Hameeteman, K., Klein, S., Schaap, M., Tori, F.L.,
Bouwhuijsen, Q.J.A. van den, Witteman, J.C.M., Lugt, A. van der, Vliet, LJ & Niessen, W.J. (2012).
Semiautomatic carotid lumen segmentation for quantification of lumen geometry in multispectral MRI.
Medical Image Analysis, 16(6), 1202-1215.
Tiel, J. van, Siebelt, M., Waarsing, J.H., Piscaer, T.M., Straten, M. van, Booij, R., Dijkshoorn, M.L.,
Kleinrensink, G.J., Verhaar, J.A.N., Krestin, G.P., Weinans, H.H. & Oei, E.H.G. (2012). CT arthrography
of the human knee to measure cartilage quality with low radiation dose. Osteoarthritis and Cartilage,
20(7), 678-685.
Veldhuis Kroeze, E.J.B., Stittelaar, K.J., Teeuwsen, VJ, Dijkshoorn, M.L., Amerongen, G. van, Waal, L.
van der, Kuiken, T., Krestin, G.P., Hinkula, J & Osterhaus, A.D.M.E. (2012). Consecutive CT in vivo lung
imaging as quantitative parameter of influenza vaccine efficacy in the ferret model. Vaccine, 30(51),
7391-7394.
Vukadinovic, D., Rozie, S., Gils, M.J. van, Walsum, T. van, Manniesing, R., Lugt, A. van der & Niessen,
W.J. (2012). Automated versus manual segmentation of atherosclerotic carotid plaque volume and
components in CTA: associations with cardiovascular risk factors. International Journal of
Cardiovascular Imaging, 28(4), 877-887.
Wang, X., Heimann, T, Lo, P, Sumkauskaite, M, Puderbach, M., Bruijne, M. de, Meinzer, HP & Wegner,
I (2012). Statistical tracking of tree-like tubular structures with efficient branching detection in 3D
medical image data. Physics in Medicine and Biology, 57(16), 5325-5342.
Part of book - Abstract
Bernsen, M.R., Ruggiero, A., Straten, M. van, Kotek, G., Haeck, J.C., Wielopolski, P.A. & Krestin, G.P.
(2012). Computed tomography and magnetic resonance imaging. In O Schober & B Riemann (Eds.),
Molecular Imaging in Oncology. Berlin: Springer Verlag.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-03-77-01 - Structuring of medical knowledge
Programme (brief description)
Our first line of research deals with the formalization of medical knowledge, that is the
description of knowledge according to a formal representation so that the knowledge can be
made operational in a computer system. We do not limit ourselves to knowledge that is provided
by experts or is described in journals or books, but also focus on the (semi)automatic extraction
of knowledge from documented databases. With respect to documented databases, attention is
paid to automated learning techniques for modeling medical knowledge, tailored to the specific
problems in the medical domain. This includes research in the representation and use of
uncertainty in medical knowledge, and ¿learning¿ by computers in interaction with human
experts so that the specific strengths of both human and machine are utilized. It is of great
importance to test the results of our research (both methodology and prototypes of systems) in
the diverse application domains for their usability, in close collaboration with other investigators
and clinical partners.
Key Figures
Department
Sp1
Sp2
medical informatics
0,85
4,87
Total
0,85
4,87
Sp3
0
Sp4
SpTot
1,2
6,92
1,2
6,92
T1
T2
T3
Ttot
IS
FS
OP
Ptot
0
0
1
1
8
1
0
10
Thesis
Hettne, K.M. (2012, december 20). Next-generation text-mining applied to toxicogenomics data
analysis. UM (142 pag.). Prom./coprom.: J.C.S. Kleinjans, Prof. Dr. J. van der Lei & Dr. Ir. J.A. Kors.
Article/Letter to the editor
Akhondi, SA, Kors, J.A. & Muresan, S (2012). Consistency of systematic chemical identifiers within and
between small-molecule databases. Journal of Cheminformatics, 4.
Bauer-Mehren, A, Mulligen, E.M. van, Avillach, P., Carrascosa, MD, Garcia-Serna, R, Pinero, J, Singh, B.,
Lopes, P, Oliveira, JL, Diallo, G, Helgee, EA, Boyer, S, Mestres, J, Sanz, F, Kors, J.A. & Furlong, LI
(2012). Automatic Filtering and Substantiation of Drug Safety Signals. PLoS Computational Biology,
8(4).
Kang, N., Mulligen, E.M. van & Kors, J.A. (2012). Training text chunkers on a silver standard corpus:
can silver replace gold? Bmc Bioinformatics, 13.
Kang, N., Afzal, Z, Singh, B., Mulligen, E.M. van & Kors, J.A. (2012). Using an ensemble system to
improve concept extraction from clinical records. Journal of Biomedical Informatics, 45(3), 423-428.
Mulligen, E.M. van, Fourrier-Reglat, A, Gurwitz, D, Molokhia, M, Nieto, A, Trifiro, G., Kors, J.A. &
Furlong, LI (2012). The EU-ADR corpus: Annotated drugs, diseases, targets, and their relationships.
Journal of Biomedical Informatics, 45(5), 879-884.
Patrinos, GP, Cooper, DN, Mulligen, E.M. van, Gkantouna, V, Tzimas, G, Tatum, Z, Schultes, E, Roos, M.
& Mons, B. (2012). Microattribution and nanopublication as means to incentivize the placement of
human genome variation data into the public domain. Human Mutation, 33(11), 1503-1512.
Schuemie, M.J., Sen, E., Jong, G.W. t, Soest, E.M. van, Sturkenboom, M.C.J.M. & Kors, J.A. (2012).
Automating classification of free-text electronic health records for epidemiological studies.
Pharmacoepidemiology and Drug Safety, 21(6), 651-658.
Erasmus MC – Research Annual Report 2012
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Veen, M. van, Steyerberg, E.W., Klooster, M van't, Ruige, M, Meurs, A.H.J., Lei, J. van der & Moll, H.A.
(2012). The Manchester triage system: improvements for paediatric emergency care. Emergency
Medicine Journal, 29(8), 654-659.
Warnier, MJ, Rutten, F.H., Kors, J.A., Lammers, JWJ, Boer, A. den, Hoes, A..W. & Bruin, M.L. de (2012).
Cardiac Arrhythmias in Adult Patients with Asthma. Journal of Asthma, 49(9), 942-946.
Journal Editorship/Refereeship
Gelsema, E.S. & Veenland, J.F. (Eds.). (1999). Pattern Recognition Letters, 20(11-13).
Erasmus MC – Research Annual Report 2012
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EMC NIHES-03-77-02 - Structuring of medical data
Programme (brief description)
Medical data recorded in the context of clinical care should not only be available for patient care,
but also be accessible for other purposes, such as scientific research, quality assurance, or
management. The use of computers to record medical data is a necessary first step to allow data
to be used for multiple purposes. Scientific research, however, has shown that the purpose of
data collection is closely related to the nature and content of the data recorded. Different usage
of the data creates different demands: data requirements in the context of a clinical trial are
different than those in the context of management or quality assurance.
In the research theme Structuring of Medical Data, the department of Medical Informatics studies
methodologies that allow recording of data for multiple purposes. Our research is focused on
generic models for medical data. The scientific challenge is to formulate generic models that are
applicable to different specialties. The models, however, have to be usable in daily practice. An
essential part of this research, therefore, is the validation of these models in daily care. Once
electronic patient records are available, our research focus shifts to on the actual use of the data
for multiple purposes. Together with clinicians, we study systems aimed at improving the quality
of care. Together with other disciplines we also analyze observational databases and study issues
involved in naturalistic trials.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
epidemiology
0,1
0,97
0,04
1,11
medical informatics
0,3
15,6
4,84
20,74
Total
0,4
16,57
4,88
21,85
0
T1
T2
T3
Ttot
IS
FS
OP
2
0
1
3
53
2
0
Ptot
58
Thesis
Chain, A.S.Y. (2012, oktober 09). Mind the cap. Predicting cardiovascular risk during drug development.
RUL (342 pag.). Prom./coprom.: M Danhof & Prof. Dr. M.C.J.M. Sturkenboom.
Coloma, P.M. (2012, mei 16). Mining electronic healthcare record databases to augment drug safety
surveillance. EUR (312 pag.). Prom./coprom.: Prof. Dr. M.C.J.M. Sturkenboom, Dr. G. Trifiro & Dr. M.J.
Schuemie.
Valkhoff, V.E. (2012, november 09). Use and safety of NSAIDs and aspirin. EUR (239 pag.).
Prom./coprom.: Prof. Dr. M.C.J.M. Sturkenboom & Prof. Dr. E.J. Kuipers.
Article/Letter to the editor
Bie, S. de, Verhamme, K.M.C., Straus, S.M.J.M., Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2012).
Vaccine-Based Subgroup Analysis in VigiBase Effect on Sensitivity in Paediatric Signal Detection. Drug
Safety, 35(4), 335-346.
Castellsague, J, Riera-Guardia, N, Calingaert, B, Varas-Lorenzo, C, Fourrier-Reglat, A, Nicotra, F.,
Sturkenboom, M.C.J.M. & Perez-Gutthann, S (2012). Individual NSAIDs and Upper Gastrointestinal
Complications A Systematic Review and Meta-Analysis of Observational Studies (the SOS Project). Drug
Safety, 35(12), 1127-1146.
Clockaerts, S.B.F., Osch, G.J.V.M. van, Bastiaansen-Jenniskens, Y.M., Verhaar, J.A.N., Glabbeek, F Van,
Meurs, J.B.J. van, Kerkhof, J.M., Hofman, A., Stricker, B.H.C. & Bierma-Zeinstra, S.M.A. (2012). Statin
use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study.
Annals of the Rheumatic Diseases, 71(5), 642-647.
Erasmus MC – Research Annual Report 2012
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Coloma, P.M., Trifiro, G., Schuemie, M.J., Gini, R., Herings, R, Hippisley-Cox, J, Mazzaglia, G., Picelli, G,
Corrao, G, Pedersen, L, Lei, JH & Sturkenboom, M.C.J.M. (2012). Electronic healthcare databases for
active drug safety surveillance: is there enough leverage? Pharmacoepidemiology and Drug Safety,
21(6), 611-621.
Danese, E, Montagnana, M, Johnson, JA, Rettie, AE, Zambon, CF, Lubitz, SA, Suarez-Kurtz, G, Cavallari,
LH, Zhao, L., Huang, M., Nakamura, Y, Mushiroda, T, Kringen, MK, Borgiani, P, Ciccacci, C, Au, NT,
Langaee, T, Siguret, V, Loriot, MA, Sagreiya, H, Altman, R.B., Shahin, MHA, Scott, SA, Khalifa, SI,
Chowbay, B, Suriapranata, IM, Teichert, M., Stricker, B.H.C., Taljaard, M, Botton, MR, Zhang, JE,
Pirmohamed, M., Zhang, X., Carlquist, JF, Horne, BD, Lee, MTM, Pengo, V, Guidi, GC, Minuz, P & Fava,
C (2012). Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic
Review and Meta-Analysis. Clinical Pharmacology & Therapeutics, 92(6), 746-756.
Ellinor, PT, Lunetta, KL, Albert, CM, Glazer, NL, Ritchie, MD, Smith, AV, Arking, DE, Muller-Nurasyid, M,
Krijthe, B.P., Lubitz, SA, Bis, JC, Chung, MK, Doerr, M, Ozaki, K, Roberts, JD, Smith, JG, Pfeufer, A,
Sinner, MF, Lohman, K, Ding, JZ, Smith, NL, Smith, JD, Rienstra, M., Rice, KM, Wagoner, DR Van,
Magnani, JW, Wakili, R, Clauss, S, Rotter, JI, Steinbeck, G, Launer, L.J., Davies, RW, Borkovich, M,
Harris, T.B., Lin, HH, Volker, U, Volzke, H, Milan, DJ, Hofman, A., Boerwinkle, E., Chen, LY, Soliman, EZ,
Voight, BF, Li, G., Chakravarti, A, Kubo, M, Tedrow, UB, Rose, LM, Ridker, P.M., Conen, D, Tsunoda, T,
Furukawa, T, Sotoodehnia, N, Xu, SY, Kamatani, N, Levy, D., Nakamura, Y, Parvez, B, Mahida, S, Furie,
KL, Rosand, J, Muhammad, R, Psaty, B.M., Meitinger, T, Perz, S, Wichmann, HE, Witteman, J.C.M., Kao,
WHL, Kathiresan, S, Roden, DM, Uitterlinden, A.G., Rivadeneira, F., McKnight, B, Sjogren, M, Newman,
AB, Liu, YM, Gollob, MH, Melander, O, Tanaka, T, Stricker, B.H.C., Felix, SB, Alonso, A., Darbar, D,
Barnard, J, Chasman, DI, Heckbert, SR, Benjamin, EJ, Gudnason, V & Kaab, S (2012). Meta-analysis
identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44(6), 670-U88.
Giezen, TJ, Mantel-Teeuwisse, A.K., Berg, M.J. van den, Straus, S.M.J.M., Leufkens, H.G.M., Solinge,
WW van & Egberts, TCG (2012). Rituximab-induced thrombocytopenia: a cohort study. European
Journal of Haematology, 89(3), 256-266.
Gulmez, SE, Lignot-Maleyran, S, Vries, C.S. de, Sturkenboom, M.C.J.M., Micon, S, Hamoud, F, Blin, P &
Moore, N. (2012). Administrative complexities for a European observational study despite directives
harmonising requirements. Pharmacoepidemiology and Drug Safety, 21(8), 851-856.
Hancock, DB, Artigas, MS, Gharib, SA, Henry, A, Manichaikul, A, Ramasamy, A, Loth, D.W., Imboden,
M, Koch, B, McArdle, WL, Smith, AV, Smolonska, J, Sood, A, Tang, WB, Wilk, JB, Zhai, GJ, Zhao, JH,
Aschard, H, Burkart, KM, Curjuric, I, Eijgelsheim, M., Elliott, P., Gu, XJ, Harris, T.B., Janson, C, Homuth,
G., Hysi, PG, Liu, JZ, Loehr, LR, Lohman, K, Loos, RJF, Manning, AK, Marciante, KD, Obeidat, M,
Postma, D.S., Aldrich, MC, Brusselle, GG, Chen, TH, Eiriksdottir, G, Franceschini, N, Heinrich, J., Rotter,
JI, Wijmenga, C., Williams, OD, Bentley, AR, Hofman, A., Laurie, CC, Lumley, T, Morrison, AC, Joubert,
BR, Rivadeneira Ramirez, F., Couper, DJ, Kritchevsky, SB, Liu, YM, Wjst, M, Wain, LV, Vonk, JM,
Uitterlinden, A.G., Rochat, T, Rich, SS, Psaty, B.M., O'Connor, GT, North, KE, Mirel, DB, Meibohm, B,
Launer, L.J., Khaw, KT, Hartikainen, AL, Hammond, CJ, Glaser, S, Marchini, J, Kraft, P, Wareham, NJ,
Volzke, H, Stricker, B.H.C., Spector, T.D., Probst-Hensch, NM, Jarvis, D, Jarvelin, MR, Heckbert, SR,
Gudnason, V, Boezen, M, Barr, RG, Cassano, PA, Strachan, DP, Fornage, M, Hall, IP, Dupuis, J, Tobin,
MD & London, SJ (2012). Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction
Identifies Novel Loci for Pulmonary Function. PLoS Genetics, 8(12).
He, CY, Chasman, DI, Dreyfus, J, Hwang, SJ, Ruiter, R., Sanna, S, Buring, JE, Fernandez-Rhodes, L,
Franceschini, N, Hankinson, SE, Hofman, A., Lunetta, KL, Palmieri, G, Porcu, E, Rivadeneira, F., Rose,
LM, Splansky, GL, Stolk, L., Uitterlinden, A.G., Chanock, SJ, Crisponi, L, Demerath, EW, Murabito, JM,
Ridker, P.M., Stricker, B.H.C. & Hunter, DJ (2012). Reproductive aging-associated common genetic
variants and the risk of breast cancer. Breast Cancer Research, 14(2).
Heintjes, E.M., Beest, F.J.A. van, Plat, AW, Meerding, W.J., Webb, K, Sturkenboom, M.C.J.M. & Herings,
R.M.C. (2012). Cholesterol Level Goal Attainment with Statins: Clinical Management Guideline
Recommendations versus Management in Actual Clinical Practice. Pharmacotherapy, 32(7), 631-641.
Erasmus MC – Research Annual Report 2012
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Herwaarden, MFWV, Kramers, C., Sturkenboom, M.C.J.M., Bemt, P.M.L.A. van den & Smet, P.A.G.M. de
(2012). Targeting Outpatient Drug Safety Recommendations of the Dutch HARM-Wrestling Task Force.
Drug Safety, 35(3), 245-259.
Heuvers, M.E., Wisnivesky, J, Stricker, B.H.C. & Aerts, J.G. (2012). Generalizability of results from the
National Lung Screening Trial. European Journal of Epidemiology, 27(9), 669-672.
Heuvers, M.E., Stricker, B.H.C. & Aerts, J.G.J.V. (2012). Generalizing Lung-Cancer Screening Results.
New England Journal of Medicine, 366(2), 192-193.
Heuvers, M.E., Aerts, J.G.J.V., Hegmans, J.P.J.J., Veltman, J.D., Uitterlinden, A.G., Ruiter, R,
Rodenburg, E.M., Hofman, A., Bakker, M., Hoogsteden, H.C., Stricker, B.H.C. & Klaveren, R.J. van
(2012). History of tuberculosis as an independent prognostic factor for lung cancer survival. Lung
Cancer, 76(3), 452-456.
Heuvers, M.E., Hegmans, J.P.J.J., Stricker, B.H.C. & Aerts, J.G. (2012). Improving lung cancer survival;
time to move on. BMC Pulmonary Medicine, 12.
Ittermann, T, Noord, C. van, Friedrich, N, Dorr, M, Felix, SB, Nauck, M., Volzke, H, Hofman, A.,
Witteman, J.C.M., Stricker, B.H.C. & Wallaschofski, H. (2012). The association between insulin-like
growth factor-I and cardiac repolarization. Growth Hormone and IGF Research, 22(1), 1-5.
Keyser, C.E. de, Stricker, B.H.C. & Becker, M.L. (2012). Genetic determinants of statin therapy: studies
after the GWA. Pharmacogenomics, 13(1), 15-16.
Koehler, E.M., Schouten, J.N.L., Hansen, B.E., Rooij, F.J.A. van, Hofman, A., Stricker, B.H.C. & Janssen,
H.L.A. (2012). Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from
the Rotterdam study. Journal of Hepatology, 57(6), 1305-1311.
Kramer, M.A., Maas, N.A.T. van der, Soest, E.M. van, Kemmeren, JM, Melker, H.E. de & Sturkenboom,
M.C.J.M. (2012). Incidence of Multiple Sclerosis in the General Population in the Netherlands,
1996-2008. Neuroepidemiology, 39(2), 96-102.
Leening, M.J.G., Elias-Smale, S.E., Kavousi, M., Felix, J.F., Deckers, J.W., Vliegenthart, R., Oudkerk,
M.., Hofman, A., Steyerberg, E.W., Stricker, B.H.C. & Witteman, J.C.M. (2012). Coronary Calcification
and the Risk of Heart Failure in the Elderly The Rotterdam Study. JACC-cardiovascular imaging, 5(9),
874-880.
Leening, M.J.G., Kavousi, M., Heeringa, J., Rooij, F.J.A. van, Heemst, J. van, Deckers, J.W., Mattace
Raso, F.U.S., Ziere, G., Hofman, A., Stricker, B.H.C. & Witteman, J.C.M. (2012). Methods of data
collection and definitions of cardiac outcomes in the Rotterdam Study. European Journal of
Epidemiology, 27(3), 173-185.
Leeuwen, N. van, Nijpels, G., Becker, M.L., Deshmukh, H, Zhou, K, Stricker, B.H.C., Uitterlinden, A.G.,
Hofman, A., Riet, E van, Palmer, CNA, Guigas, B, Slagboom, P.E., Durrington, P, Calle, RA, Neil, A,
Hitman, G, Livingstone, SJ, Colhoun, H, Holman, RR, McCarthy, MI, Dekker, J.M., Hart, L.M. 't &
Pearson, E.R. (2012). A gene variant near ATM is significantly associated with metformin treatment
response in type 2 diabetes: a replication and meta-analysis of five cohorts. Diabetologia, 55(7),
1971-1977.
Loiacono, C, Sgroi, C, Coppolino, S, Cannata, A, Ferrara, R, Arcoraci, V, Cananzi, P, Savica, V,
Schuemie, M.J., Caputi, AP & Trifiro, G. (2012). How Much are Biosimilars Used in Southern Italy? A
Retrospective Analysis of Epoetin Utilization in the Local Health Unit of Messina in the Years 2010-2011.
BioDrugs, 26(2), 113-120.
Erasmus MC – Research Annual Report 2012
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Marchisio, P, Cantarutti, L., Sturkenboom, M.C.J.M., Girotto, S, Picelli, G, Dona, D, Scamarcia, A, Villa,
M. & Giaquinto, C. (2012). Burden of acute otitis media in primary care pediatrics in Italy: a secondary
data analysis from the Pedianet database. BMC Pediatrics, 12.
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Antithrombotic Medication and Incident
Open-Angle Glaucoma. Investigative Ophthalmology & Visual Science, 53(7), 3801-3805.
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Cholesterol-Lowering Drugs and Incident
Open-Angle Glaucoma: A Population-Based Cohort Study. PLoS One, 7(1).
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Corticosteroids and Open-Angle Glaucoma in the
Elderly A Population-Based Cohort Study. Drugs & Aging, 29(12), 963-970.
Marroun El, H., Jaddoe, V.W.V.K., Hudziak, J.J., Roza, S.J., Steegers, E.A.P., Hofman, A., Verhulst, F.C.,
White, T.J.H., Stricker, B.H.C. & Tiemeier, H.W. (2012). Maternal Use of Selective Serotonin Reuptake
Inhibitors, Fetal Growth, and Risk of Adverse Birth Outcomes. Archives of General Psychiatry, 69(7),
706-714.
Mokhles, M.M., Trifiro, G., Dieleman, J.P., Haag, MD, Soest, E.M. van, Verhamme, K.M.C., Mazzaglia,
G., Herings, R, Luise, C de, Ross, D., Brusselle, G., Colao, A., Haverkamp, W, Schade, R, Camp, G.,
Zanettini, R & Sturkenboom, M.C.J.M. (2012). The risk of new onset heart failure associated with
dopamine agonist use in Parkinson's disease. Pharmacological Research, 65(3), 358-364.
Piening, S, Haaijer-Ruskamp, F.M., Graeff, PA de, Straus, S.M.J.M. & Mol, PGM (2012). Healthcare
Professionals' Self-Reported Experiences and Preferences Related to Direct Healthcare Professional
Communications A Survey Conducted in the Netherlands. Drug Safety, 35(11), 1061-1072.
Piening, S, Haaijer-Ruskamp, F.M., Vries, JTN de, Elst, ME van der, Graeff, PA de, Straus, S.M.J.M. &
Mol, PGM (2012). Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review.
Drug Safety, 35(5), 373-385.
Piening, S, Reber, KC, Wieringa, J.E., Straus, S.M.J.M., Graeff, PA de, Haaijer-Ruskamp, F.M. & Mol,
PGM (2012). Impact of Safety-Related Regulatory Action on Drug Use in Ambulatory Care in the
Netherlands. Clinical Pharmacology & Therapeutics, 91(5), 838-845.
Ray, K, Wainwright, NWJ, Visser, L., Witteman, J.C.M., Breteler, M.M.B., Ambegaonkar, B, Hofman, A.,
Stricker, B.H.C., Wareham, N, Khaw, KT & Sandhu, M (2012). Changes in HDL cholesterol and
cardiovascular outcomes after lipid modification therapy. Heart, 98(10), 780-785.
Rodenburg, E.M., Eijgelsheim, M., Geleijnse, J.M., Amin, N., Duijn, C.M. van, Hofman, A., Uitterlinden,
A.G., Stricker, B.H.C. & Visser, L.E. (2012). CYP1A2 and coffee intake and the modifying effect of sex,
age, and smoking. American Journal of Clinical Nutrition, 96(1), 182-187.
Rodenburg, E.M., Stricker, B.H.C. & Visser, L.E. (2012). Sex differences in cardiovascular drug-induced
adverse reactions causing hospital admissions. British Journal of Clinical Pharmacology, 74(6),
1045-1052.
Rodenburg, E.M., Stricker, B.H.C. & Visser, L.E. (2012). Ziekenhuisopname door bijwerkingen:
verschillen tussen man en vrouw. Nederlands Tijdschrift voor Geneeskunde, 156(49).
Ruiter, R. de, Teichert, M., Straus, S.M.J.M., Stricker, B.H.C. & Visser, L.E. (2012). Concomitant Use of
Contraceptives and Potentially Teratogenic Medicinal Products-Results From a Study Using Pharmacy
Dispensing Data in the Netherlands. Reproductive Sciences, 19(9), 987-994.
Erasmus MC – Research Annual Report 2012
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Ruiter, R. de, Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Lower Risk of Cancer in Patients on
Metformin in Comparison With Those on Sulfonylurea Derivatives Results from a large population-based
follow-up study. Diabetes Care, 35(1), 119-124.
Ruiter, R. de, Visser, L.E., Herk-Sukel, MPP van, Geelhoed-Duijvestijn, PH, Bie, S. de, Straus, S.M.J.M.,
Mol, PGM, Romio, S.A., Herings, R.M.C. & Stricker, B.H.C. (2012). Prescribing of Rosiglitazone and
Pioglitazone Following Safety Signals Analysis of Trends in Dispensing Patterns in the Netherlands from
1998 to 2008. Drug Safety, 35(6), 471-480.
Ruiter, R., Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Risk of cancer in patients on insulin glargine
and other insulin analogues in comparison with those on human insulin: results from a large
population-based follow-up study. Diabetologia, 55, 51-62.
Schie, R.M.F. van, Khedr, N el, Verhoef, T.I., Teichert, M., Stricker, B.H.C., Hofman, A., Buhre, PN,
Wessels, J.A.M., Schalekamp, T., Cessie, S. le, Meer, F.J.M. van der, Rosendaal, F.R., Boer, A. den, Zee,
A.H. & Visser, L.E. (2012). Validation of the acenocoumarol EU-PACT algorithms: similar performance in
the Rotterdam Study cohort as in the original study. Pharmacogenomics, 13(11), 1239-1245.
Schuemie, M.J. (2012). Safety surveillance of longitudinal databases: further methodological
considerations. Pharmacoepidemiology and Drug Safety, 21(6), 670-672.
Schuemie, M.J., Coloma, P.M., Straatman, H., Herings, R.M.C., Trifiro, G., Matthews, JN, Prieto-Merino,
D, Molokhia, M, Pedersen, L, Gini, R., Innocenti, F, Mazzaglia, G., Picelli, G, Scotti, L, Lei, J. van der &
Sturkenboom, M.C.J.M. (2012). Using Electronic Health Care Records for Drug Safety Signal Detection A
Comparative Evaluation of Statistical Methods. Medical Care, 50(10), 890-897.
Trifiro, G., Mokhles, M.M., Dieleman, J.P., Soest, E.M. van, Verhamme, K.M.C., Mazzaglia, G., Herings,
R, Luise, C de, Ross, D., Brusselle, G., Colao, A., Haverkamp, W, Schade, R, Camp, G., Zanettini, R &
Sturkenboom, M.C.J.M. (2012). Risk of Cardiac Valve Regurgitation with Dopamine Agonist use in
Parkinson's Disease and Hyperprolactinaemia A Multi-Country, Nested Case-Control Study. Drug Safety,
35(2), 159-171.
Valkhoff, V.E., Soest, E.M. van, Mazzaglia, G., Molokhia, M, Schade, R, Trifiro, G., Goldstein, J.L.,
Hernandez-Diaz, S, Kuipers, E.J. & Sturkenboom, M.C.J.M. (2012). Adherence to gastroprotection
during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: A
population-based study. Arthritis & Rheumatism, 64(8), 2792-2802.
Valkhoff, V.E., Soest, E.M. van, Masclee, G.M.C., Bie, S. de, Mazzaglia, G., Molokhia, M, Kuipers, E.J. &
Sturkenboom, M.C.J.M. (2012). Prescription of nonselective NSAIDs, coxibs and gastroprotective
agents in the era of rofecoxib withdrawal - a 617 400-patient study. Alimentary Pharmacology &
Therapeutics, 36(8), 790-799.
Valkhoff, V.E., Sturkenboom, M.C.J.M. & Kuipers, E.J. (2012). Risk factors for gastrointestinal bleeding
associated with low-dose aspirin. Best Practice & Research in Clinical Gastroenterology, 26(2), 125-140.
Veldhuis, J., Dieleman, J.P., Wohlfarth, T, Storosum, J.G., Brink, W van den, Sturkenboom, M.C.J.M. &
Denys, D. (2012). Incidence and prevalence of "diagnosed OCD" in a primary care, treatment seeking,
population. International Journal of Psychiatry in Clinical Practice, 16(2), 85-92.
Verhamme, K.M.C., Afonso, ASM, Noord, C. van, Haag, MD, Koudstaal, P.J., Brusselle, GGO &
Sturkenboom, M.C.J.M. (2012). Tiotropium Handihaler and the risk of cardio- or cerebrovascular events
and mortality in patients with COPD. Pulmonary Pharmacology & Therapeutics, 25 (1), 19-26.
Wilk, JB, Shrine, NRG, Loehr, LR, Zhao, JH, Manichaikul, A, Lopez, LM, Smith, AV, Heckbert, SR,
Smolonska, J, Tang, WB, Loth, D.W., Curjuric, I, Hui, J, Cho, MH, Latourelle, JC, Henry, AP, Aldrich, M,
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< back to index
Bakke, P, Beaty, TH, Bentley, AR, Borecki, IB, Brusselle, GG, Burkart, KM, Chen, TH, Couper, D, Crapo,
JD, Davies, G., Dupuis, J, Franceschini, N, Gulsvik, A, Hancock, DB, Harris, T.B., Hofman, A., Imboden,
M, James, AL, Khaw, KT, Lahousse, L, Launer, L.J., Litonjua, A, Liu, YM, Lohman, KK, Lomas, DA,
Lumley, T, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, Musk, AW, Myers, R.H., North, KE,
Postma, D.S., Psaty, B.M., Rich, SS, Rivadeneira, F., Rochat, T, Rotter, JI, Artigas, MS, Starr, JM,
Uitterlinden, A.G., Wareham, NJ, Wijmenga, C., Zanen, P, Province, MA, Silverman, EK, Deary, IJ,
Palmer, LJ, Cassano, PA, Gudnason, V, Barr, RG, Loos, RJF, Strachan, DP, London, SJ, Boezen, H.M.,
Probst-Hensch, N, Gharib, SA, Hall, IP, O'Connor, GT, Tobin, MD & Stricker, B.H.C. (2012).
Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow
Obstruction. American Journal of Respiratory and Critical Care Medicine, 186(7), 622-632.
Willemen, M.J.C., Mantel-Teeuwisse, A.K., Buggy, Y, Layton, D, Straus, S.M.J.M., Leufkens, H.G.M. &
Egberts, TCG (2012). Reasons for and Time to Discontinuation of Rimonabant Therapy A Modified
Prescription-Event Monitoring Study. Drug Safety, 35(12), 1147-1158.
Zomerdijk, I.M., Sayed-Tabatabaei, F.A., Trifiro, G., Blackburn, SCF, Sturkenboom, M.C.J.M. & Straus,
S.M.J.M. (2012). Risk Minimization Activities of Centrally Authorized Products in the EU A Descriptive
Study. Drug Safety, 35(4), 299-314.
Journal Editorship/Refereeship
Lei, J. van der, Moorman, P.W. & Musen, M.A. (Eds.). (1999). Methods of Information in Medicine, 38.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-04-55-01 - Assessment, Aetiology and Course of Child and Adolescent
Psychiatric Disorders
Programme (brief description)
Focus of research
The main objective of this program is to study the frequency, determinants and course of child
psychiatric disorders, such as anxiety, depression, somatoform disorders, aggressive and
antisocial behaviours, hyperactivity, and developmental problems (autism, learning disorders,
mental retardation). The program uses epidemiological methods to study psychopathology in
general population, at risk, and clinical samples. These studies aim to develop assessment
instruments and diagnostic procedures; assess the prevalence and incidence of child and
adolescent disorders; study the onset and course of psychopathology from infancy to young
adulthood using longitudinal and genetically sensitive research designs; assess the effectiveness
of preventive and treatment approaches.
¿General population studies
The prevalence and course of child and adolescent psychiatric conditions has been studied in
Dutch general population samples across the age range from 2 to 30 years. The influence of life
events and personal and social-environmental determinants has been studied, and cross-cultural
and secular trend analyses have been performed. These studies confirmed the high prevalence
(7%) of serious psychiatric problems in Dutch children and adolescents as well as the
cross-cultural similarity of child/adolescent psychopathology, and indicated that the use of
mental health services at this age is mainly determined by severity of psychopathology,
additional handicaps, and family burden. Longitudinal studies showed that earlier
psychopathology is the strongest predictor of later psychopathology from childhood up to early
adulthood, and is a strong predictor of later functional problems. Recently, the transgenerational
transmission of psychopathology is being studies in a 24-year longitudinal design in which
parental ratings of children¿s problem behaviour is compared with ratings on the same
instrument obtained for the offspring 24 years later. Studies in general population samples also
yielded improvements in the standardized assessment of psychopathology, ad well as
contributions to the methodology of longitudinal studies (accelerated designs; developmental
pathway analysis). The second generation of longitudinal studies in which determinants of the
emergence and continuity of child psychopathology is being studied is well on its way. The focus
is on two new large-scale longitudinal studies. The first, Generation R, is a multidisciplinary
cohortstudy following 10.000 children from prebirth into young adulthood. The second,Trails, is a
cohortstudy of 2.500 10-year-olds in the northern provinces. The Rotterdam group focuses on
anxiety disorders, illegal substance use, and conduct disorders. Both Generation R and Trails aim
to unravel etiological mechanisms, with a special focus on biological determinants and
gene-enviroment interactions and correlations. The first results of Generation R show the effects
of smoking (both cannabis and cigarettes) on intrauterine growth and on early brain
development. In Trails the associations between between autonomous nervous functioning and
HPA axis functioning with both externalizing and internalizing problems have been studied.
¿At risk and clinical populations
We have assessed the prevalence and longitudinal course of problem behaviours and quality of
life in ethnic minority groups, adopted children, children and adolescents with mental
retardation, children with psychiatric conditions, and children with medical conditions (e.g.
craniofacial abnormalities, congenitial cardiac conditions, meningococcal sepsis). Several
studies on referred samples showed a very strong continuity of psychopathology up to 10 years
after referral. Only few factors (learning problems, temperament, stress, family functioning)
showed predictive power of later psychopathology over and above severity of earlier
psychopathology. However, (chronic) physical problems appear to have considerable power in
the prediction of later psychopathology (e.g. in mentally retarded children and adolescents).
Studies on samples with chronic somatic disorders show the importance of cerebral involvement
in child development, as well as the important role of psychological and personality factors in
coping with these conditions. Intervention studies aiming anxiety disorders have started. We
have recently formed a cohort of children with autism spectrum who had been referred to mental
Erasmus MC – Research Annual Report 2012
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health services in the southwest of The Netherlands as a basis for a number of studies including
diagnostic assessment studies, family studies, and intervention studies.
¿Genetics
In collaboration with the Free University Amsterdam, we have conducted (longitudinal) twin and
adoption studies to determine genetic and environmental influences on problem behaviours in
young children. Recent findings show changes in genetic influences on psychopathology from
preschool- to school age, differential genetic and environmental influences on co-morbid
psychopathological problems as well as genetic influences on the stability of problem behaviours.
Considerable contributions have been made to the development of estimation methods in
quantitative behavioural genetics (e.g. rater bias models). The behavioural genetic studies
continue the study of large genetically sensitive samples (twins; adopted children) well into
puberty using longitudinal designs and now include the detection of genetically sensitive
syndromes of psychopathology (e.g. disruptive disorders). We are currently expanding this
research by looking at the association between child psychiatric disorders (ADHD, anxiety
disorders) and presynaptic gene networks in a large clinical population.
Key Figures
Department
Sp1
pediatric psychiatry
5,94
Total
5,94
Sp2
Sp3
0
0
Sp4
SpTot
5,76
11,7
5,76
11,7
T1
T2
T3
Ttot
IS
FS
OP
Ptot
3
0
0
3
81
3
22
109
Thesis
Batenburg-Eddes, T. van (2012, september 27). Causes and consequences of infant neuromotor
development. The generation R study. EUR (207 pag.). Prom./coprom.: Prof.dr. H.W. Tiemeier & Prof.
Dr. F.C. Verhulst.
Robbers, S.C.C. (2012, april 19). The development of children's
Prom./coprom.: Prof. Dr. F.C. Verhulst & D.I. Boomsma.
problem behaviors. EUR (143 pag.).
Velders, F.P. (2012, oktober 31). Genes, parental psychiatric symptons and child emotional problems.
EUR (201 pag.). Prom./coprom.: Prof.dr. H.W. Tiemeier & Prof. Dr. F.C. Verhulst.
Article/Letter to the editor
Abdallah, MW, Pearce, BD, Larsen, N, Greaves-Lord, K., Norgaard-Pedersen, B, Hougaard, DM,
Mortensen, EL & Grove, J (2012). Amniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum
Disorders: An Exploratory Study. Autism Research, 5(6), 428-433.
Amin, N., Byrne, E, Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I.M., Vink, J.M., Rawal, R,
Mangino, M, Teumer, A, Keers, JC, Verwoert, G, Baumeister, S, Biffar, R, Petersmann, A, Dahmen, N,
Doering, A, Isaacs, A, Broer, L., Wray, NR, Montgomery, GW, Levy, D., Psaty, B.M., Gudnason, V,
Chakravarti, A, Sulem, P, Gudbjartsson, DF, Kiemeney, LA, Thorsteinsdottir, U, Stefansson, K, Rooij,
F.J.A. van, Aulchenko, Y.S., Hottenga, J.J., Rivadeneira, FR, Hofman, A., Uitterlinden, A.G., Hammond,
CJ, Shin, SY, Ikram, A., Witteman, J.C.M., Janssens, A.C.J.W., Snieder, H, Tiemeier, H.W.,
Wolfenbuttel, BHR, Oostra, B.A., Heath, AC, Wichmann, E, Spector, T.D., Grabe, HJ, Boomsma, D.I.,
Martin, NG & Duijn, C.M. van (2012). Genome-wide association analysis of coffee drinking suggests
association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17(11), 1116-1129.
Bakker, MP, Ormel, J., Verhulst, F.C. & Oldehinkel, A.J. (2012). Childhood Family Instability and Mental
Health Problems During Late Adolescence: A Test of Two Mediation Models-The TRAILS Study. Journal
of Clinical Child and Adolescent Psychology, 41(2), 166-176.
Berghmans, J, Weber, F., Akoleyen, C van, Utens, E.M.W.J., Adriaenssens, P, Klein, J. & Himpe, D
(2012). Audiovisual aid viewing immediately before pediatric induction moderates the accompanying
parents' anxiety. Paediatric Anaesthesia, 22(4), 386-392.
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Berkien, M., Louwerse, S.C., Verhulst, F.C. & Ende, J. van der (2012). Children's perceptions of
dissimilarity in parenting styles are associated with internalizing and externalizing behavior. European
Child & Adolescent Psychiatry, 21(2), 79-85.
Bevaart, F., Mieloo, C.L., Jansen, W., Raat, H., Donker, M.C.H., Verhulst, F.C. & Oort, F.V.A. van (2012).
Ethnic differences in problem perception and perceived need for care for young children with problem
behaviour. Journal of Child Psychology and Psychiatry, 53(10), 1063-1071.
Boer, S.B.B. de, Oort, F.V.A. van, Donker, M.C.H., Verheij, F. & Boon, AE (2012). Childhood
Characteristics of Adolescent Inpatients with Early-Onset and Adolescent-Onset Disruptive Behavior.
Journal of Psychopathology and Behavioral Assessment, 34(3), 415-422.
Bosch, NM, Riese, H, Reijneveld, S.A., Bakker, MP, Verhulst, F.C., Ormel, J. & Oldehinkel, A.J. (2012).
Timing matters: Long term effects of adversities from prenatal period up to adolescence on adolescents'
cortisol stress response. The TRAILS study. Psychoneuroendocrinology, 37(9), 1439-1447.
Bron, T.I., Rijen, E.H.M. van, Abeelen, A.M. van & Berg, M.P. van den (2012). DEVELOPMENT OF
REGULATION DISORDERS INTO SPECIFIC PSYCHOPATHOLOGY. Infant Mental Health Journal, 33(2),
212-221.
Bruin, E.I. de & Verheij, F. (2012). Social skills training in children with PDD-NOS: An exploratory study.
International Journal of Psychiatry in Clinical Practice, 16(1), 60-67.
Bruin, E.I. de, Nijs, P.F.A. de, Verhulst, F.C. & Huizink, A.C. (2012). The association between formal
thought disorder and finger print asymmetry in children with a psychiatric disorder: an exploratory
study. European Child & Adolescent Psychiatry, 21(12), 691-698.
Cents, R.A.M., Tiemeier, H.W., Velders, F.P., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C., Berg, M.P.
van den & Hudziak, J.J. (2012). Maternal smoking during pregnancy and child emotional problems: The
relevance of maternal and child 5-HTTLPR genotype. American Journal of Medical Genetics Part
B-Neuropsychiatric Genetics, 159B(3), 289-297.
Creemers, H.E., Vollebergh, W.A.M., Ormel, J., Verhulst, F.C. & Huizink, A.C. (2012). Temperament en
riskant cannabisgebruik in de adolescentie. Kind en Adolescent, 33, 21-34.
Cullen, KR, Wallace, S, Magnotta, VA, Bockholt, J, Ehrlich, S, Gollub, RL, Manoach, DS, Ho, BC, Clark,
VP, Lauriello, J, Bustillo, JR, Schulz, SC, Andreasen, N.C., Calhoun, VD, Lim, KO & White, T.J.H. (2012).
Cigarette smoking and white matter microstructure in schizophrenia. Psychiatry
Research-Neuroimaging, 201(2), 152-158.
Darlington, A.S., Verhulst, F.C., Winter, A.F. de, Ormel, J., Passchier, J. & Hunfeld, J.A.M. (2012). The
influence of maternal vulnerability and parenting stress on chronic pain in adolescents in a general
population sample: The TRAILS study. European Journal of Pain-London, 16(1), 150-159.
Dekker, M.J.H.J., Tiemeier, H.W., Luijendijk, H.J., Kuningas, M., Hofman, A., Jong, F.H. de, Stewart,
P.M., Koper, F.J.W. & Lamberts, S.W.J. (2012). The Effect of Common Genetic Variation in 11
beta-Hydroxysteroid Dehydrogenase Type 1 on Hypothalamic-Pituitary-Adrenal Axis Activity and
Incident Depression. Journal of Clinical Endocrinology and Metabolism, 97(2), E233-E237.
Dierckx, B., Dieleman, G., Tulen, J.H.M., Treffers, PDA, Utens, E.M.W.J., Verhulst, F.C. & Tiemeier,
H.W. (2012). Persistence of anxiety disorders and concomitant changes in cortisol. Journal of Anxiety
Disorders, 26(6), 635-641.
Dijk, M. van, Knoester, H, Beusekom, B.S. van & Ista, W.G. (2012). Screening pediatric delirium with an
adapted version of the Sophia Observation withdrawal Symptoms scale (SOS). Intensive Care Medicine,
38(3), 531-532.
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Direk, N., Koudstaal, P.J., Hofman, A., Ikram, M.A., Hoogendijk, W.J.G. & Tiemeier, H.W. (2012).
Cerebral Hemodynamics and Incident Depression: The Rotterdam Study. Biological Psychiatry, 72(4),
318-323.
Duvekot, J. & Greaves-Lord, K. (2012). Congres Review: NVA Autisme congres op 7 en 8 oktober 2011.
Wetenschappelijk Tijdschrift Autisme, 1, 21-22.
El Marroun, H. (2012). Selectieve serotonineheropnameremmers kunnen foetale hoofdgroei
beinvloeden. Tijdschrift voor Psychiatrie, 54, 483-484.
Ende, J. van der, Verhulst, F.C. & Tiemeier, H.W. (2012). Agreement of Informants on Emotional and
Behavioral Problems From Childhood to Adulthood. Psychological Assessment, 24(2), 293-300.
Ertel, K.A., Kleinman, K, Rossem, L. van, Sagiv, S, Tiemeier, H.W., Hofman, A., Jaddoe, V.W.V.K. &
Raat, H. (2012). Maternal perinatal depression is not independently associated with child body mass
index in the Generation R Study: methods and missing data matter. Journal of Clinical Epidemiology,
65(12), 1300-1309.
Euser, A.S. & Franken, I.H.A. (2012). Alcohol affects the emotional modulation of cognitive control: an
event-related brain potential study. Psychopharmacology, 222(3), 459-476.
Euser, A.S., Arends, L.R., Evans, B.E., Greaves-Lord, K., Huizink, A.C. & Franken, I.H.A. (2012). The
P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: A
meta-analytic investigation. Neuroscience and Biobehavioral Reviews, 36(1), 572-603.
Evans, B.E., Greaves-Lord, K., Euser, A.S., Tulen, J.H.M., Franken, I.H.A. & Huizink, A.C. (2012).
Alcohol and tobacco use and heart rate reactivity to a psychosocial stressor in an adolescent population.
Drug & Alcohol Dependence, 126(3), 296-303.
Evans, B.E., Greaves-Lord, K., Euser, A.S., Franken, I.H.A. & Huizink, A.C. (2012). The relation between
hypothalamic-pituitary-adrenal (HPA) axis activity and age of onset of alcohol use. Addiction, 107(2),
312-322.
Flink, I.J.E., Jansen, P.W., Beirens, T.M.J., Tiemeier, H.W., IJzendoorn, M.H. van, Jaddoe, V.W.V.K.,
Hofman, A. & Raat, H. (2012). Differences in problem behaviour among ethnic minority and majority
preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators:
the Generation R Study. Bmc Public Health, 12.
Ghassabian, A. & Tiemeier, H.W. (2012). Is measurement of maternal serum TSH sufficient screening in
early pregnancy? A case for more randomized trials. Clinical Endocrinology, 77(6), 802-805.
Ghassabian, A., Bongers-Schokking, J.J., Rijke, Y.B. de, Mil, N van, Jaddoe, V.W.V.K., Muinck
Keizer-Schrama, S.M.P.F., Hooijkaas, H., Hofman, A., Visser, W.E., Roman, GC, Visser, T.J., Verhulst,
F.C. & Tiemeier, H.W. (2012). Maternal Thyroid Autoimmunity During Pregnancy and the Risk of
Attention Deficit/Hyperactivity Problems in Children: The Generation R Study. Thyroid, 22(2), 178-186.
Graaff, J. de, Roza, S.J., Steegers, E.A.P., Hofman, A., Verhulst, F.C., Jaddoe, V.W.V.K. & Tiemeier,
H.W. (2012). Maternal folate status in early pregnancy and child emotional and behavioral problems:
the Generation R Study. American Journal of Clinical Nutrition, 95(6), 1413-1421.
Greaves-Lord, K., Eussen, M.L.J.M., Duvekot, J., Louwerse, S.C., Hoopen, L.W. ten & Nijs, P.F.A. de
(2012). Dimensionele en categoriale diagnostiek als solide basis voor zorg en onderzoek.
Wetenschappelijk Tijdschrift Autisme, 2, 68-71.
Harakeh, Z, Sonneville, L de, Eijnden, R.J.J.M. van den, Huizink, A.C., Reijneveld, S.A., Ormel, J.,
Verhulst, F.C., Monshouwer, K. & Vollebergh, W.A.M. (2012). The Association Between Neurocognitive
Functioning and Smoking in Adolescence: The TRAILS Study. Neuropsychology, 26(5), 541-550.
Erasmus MC – Research Annual Report 2012
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Hollander, EL de, Bemelmans, W.J.E., Boshuizen, H.C., Friedrich, N, Wallaschofski, H., Guallar-Castillon,
P, Walter, S., Zillikens, M.C., Rosengren, A, Lissner, L, Bassett, JK, Giles, G.G., Orsini, N, Heim, N,
Visser, M. & Groot, LCPGM de (2012). The association between waist circumference and risk of
mortality considering body mass index in 65-to 74-year-olds: a meta-analysis of 29 cohorts involving
more than 58 000 elderly persons. International Journal of Epidemiology, 41(3), 805-817.
Huizink, A.C., Greaves-Lord, K., Evans, B.E., Euser, A.S., Ende, J. van der, Verhulst, F.C. & Franken,
I.H.A. (2012). Youth in the Netherlands Study (JOiN): study design. Bmc Public Health, 12.
Jaddoe, V.W.V.K., Duijn, C.M. van, Franco, O.H., Heijden, A.J. van der, IIzendoorn, MH van, Jongste,
J.C. de, Lugt, A. van der, Mackenbach, J.P., Moll, H.A., Raat, H., Rivadeneira Ramirez, F., Steegers,
E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2012). The Generation R Study:
design and cohort update 2012. European Journal of Epidemiology, 27(9), 739-756.
Jansen, P.W., Roza, S.J., Jaddoe, V.W.V.K., Mackenbach, J.P., Raat, H., Hofman, A., Verhulst, F.C. &
Tiemeier, H.W. (2012). Children's eating behavior, feeding practices of parents and weight problems in
early childhood: results from the population-based Generation R Study. International Journal of
Behavioral Nutrition and Physical Activity, 9(130).
Jansen, P.W., Raat, H., Mackenbach, J.P., Hofman, A., Jaddoe, V.W.V.K., Bakermans-Kranenburg, MJ,
Ijzerdoorn, M.H. van, Verhulst, F.C. & Tiemeier, H.W. (2012). Early Determinants of Maternal and
Paternal Harsh Discipline: The Generation R Study. Family Relations, 61(2), 253-270.
Jansen, P.W., Verlinden, M., Berkel, A. van, Mieloo, C, Ende, J. van der, Veenstra, R., Verhulst, F.C.,
Jansen, W. & Tiemeier, H.W. (2012). Prevalence of bullying and victimization among children in early
elementary school: Do family and school neighbourhood socioeconomic status matter? Bmc Public
Health, 12.
Janssens, KAM, Oldehinkel, A.J., Verhulst, F.C., Hunfeld, J.A.M., Ormel, J. & Rosmalen, J..G.M. (2012).
Symptom-specific associations between low cortisol responses and functional somatic symptoms: The
TRAILS study. Psychoneuroendocrinology, 37(3), 332-340.
Jaspers, M, Winter, A.F. de, Veenstra, R., Ormel, J., Verhulst, F.C. & Reijneveld, S.A. (2012). Preventive
Child Health Care Findings on Early Childhood Predict Peer-Group Social Status in Early Adolescence.
Journal of Adolescent Health, 51(6), 637-642.
Jaspers, M, Winter, A.F. de, Huisman, M., Verhulst, F.C., Ormel, J., Stewart, RE & Reijneveld, S.A.
(2012). Trajectories of Psychosocial Problems in Adolescents Predicted by Findings From Early
Well-Child Assessments. Journal of Adolescent Health, 51(5), 475-483.
Jorg, F, Ormel, J., Reijneveld, S.A., Jansen, DEMC, Verhulst, F.C. & Oldehinkel, A.J. (2012). Puzzling
Findings in Studying the Outcome of "Real World" Adolescent Mental Health Services: The TRAILS
Study. PLoS One, 7(9).
Jorge, RE, Acion, L, White, T.J.H., Tordesillas-Gutierrez, D, Pierson, R, Crespo-Facorro, B & Magnotta,
VA (2012). White Matter Abnormalities in Veterans With Mild Traumatic Brain Injury. American Journal
of Psychiatry, 169(12), 1284-1291.
Kamp, JM van de, Pouwels, P.J.W., Aarsen, F.K., Hoopen, L.W. ten, Knol, D.L., Klerk, J.B.C. de, Coo,
I.F.M. de, Huijmans, J.G.M., Jakobs, C., Knaap, M.S. van der, Salomons, G.S. & Mancini, G.M.S. (2012).
Long-term follow-up and treatment in nine boys with X-linked creatine transporter defect. Journal of
Inherited Metabolic Disease, 35, 141-149.
Kiefte- de Jong, J.C., Timmermans, S., Jaddoe, V.W.V.K., Hofman, A., Tiemeier, H.W., Steegers, E.A.P.,
Jongste, J.C. de & Moll, H.A. (2012). High Circulating Folate and Vitamin B-12 Concentrations in Women
During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring.
Journal of Nutrition, 142(4), 731-738.
Erasmus MC – Research Annual Report 2012
< back to index
Kivimaki, M, Shipley, M.J., Allan, CL, Sexton, CE, Jokela, M, Virtanen, M, Tiemeier, H.W., Ebmeier, KP &
Singh-Manoux, A (2012). Vascular Risk Status as a Predictor of Later-Life Depressive Symptoms: A
Cohort Study. Biological Psychiatry, 72(4), 324-330.
Kosters, MP, Chinapaw, MJM, Zwaanswijk, M., Wal, M.F., Utens, E.M.W.J. & Koot, HM (2012). Study
design of 'FRIENDS for Life': process and effect evaluation of an indicated school-based prevention
programme for childhood anxiety and depression. Bmc Public Health, 12.
Kruizinga, I., Jansen, W., Haan, CL den, Ende, J. van der, Carter, AS & Raat, H. (2012). Reliability and
Validity of the Dutch Version of the Brief Infant-Toddler Social and Emotional Assessment (BITSEA).
PLoS One, 7(6).
Louwerse, S.C., Eussen, M.L.J.M. & Greaves-Lord, K. (2012). Het beloop van
autismespectrumstoornissen. Een "sneak preview" van 4 casussen uit een vervolgonderzoek.
Wetenschappelijk Tijdschrift Autisme, 4, 119-126.
Louwerse, S.C. & Greaves-Lord, K. (2012). Nationaal Autisme Congres 2012. Wetenschappelijk
Tijdschrift Autisme, 3, 99-101.
Luijten, M., Veltman, D.J., Hester, R., Smits, M., Pepplinkhuizen, L. & Franken, I.H.A. (2012). Brain
Activation Associated with Attentional Bias in Smokers is Modulated by a Dopamine Antagonist.
Neuropsychopharmacology, 37(13), 2772-2779.
Mackenbach, J.D., Tiemeier, H.W., Ende, J. van der, Nijs, I.M.T., Jaddoe, V.W.V.K., Hofman, A.,
Verhulst, F.C. & Jansen, P.W. (2012). Relation of Emotional and Behavioral Problems With Body Mass
Index in Preschool Children: The Generation R Study. Journal of Developmental and Behavioral
Pediatrics, 33(8), 641-648.
Marroun El, H., Jaddoe, V.W.V.K., Hudziak, J.J., Roza, S.J., Steegers, E.A.P., Hofman, A., Verhulst, F.C.,
White, T.J.H., Stricker, B.H.C. & Tiemeier, H.W. (2012). Maternal Use of Selective Serotonin Reuptake
Inhibitors, Fetal Growth, and Risk of Adverse Birth Outcomes. Archives of General Psychiatry, 69(7),
706-714.
Marroun El, H., Zeegers, M., Steegers, E.A.P., Ende, J. van der, Schenk, JJ, Hofman, A., Jaddoe,
V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2012). Post-term birth and the risk of behavioural and
emotional problems in early childhood. International Journal of Epidemiology, 41(3), 773-781.
McQuillan, R, Eklund, N, Pirastu, N, Kuningas, M., McEvoy, BP, Esko, T, Corre, T, Davies, G., Kaakinen,
M, Lyytikainen, LP, Kristiansson, K, Havulinna, AS, Gogele, M, Vitart, V, Tenesa, A, Aulchenko, Y.,
Hayward, C, Johansson, A, Boban, M, Ulivi, S, Robino, A, Boraska, V, Igl, W, Wild, SH, Zgaga, L, Amin,
N., Theodoratou, E, Polasek, O, Girotto, G, Lopez, LM, Sala, C, Lahti, J, Laatikainen, T, Prokopenko, I,
Kals, M, Viikari, J, Yang, J., Pouta, A, Estrada, K, Hofman, A., Freimer, N, Martin, NG, Kahonen, M,
Milani, L, Heliovaara, M, Vartiainen, E, Raikkonen, K, Masciullo, C, Starr, JM, Hicks, AA, Esposito, L,
Kolcic, I, Farrington, SM, Oostra, B.A., Zemunik, T, Campbell, H, Kirin, M, Pehlic, M, Faletra, F,
Porteous, D, Pistis, G, Widen, E, Salomaa, V, Koskinen, S, Fischer, K., Lehtimaki, T, Heath, A, McCarthy,
MI, Rivadeneira, F., Montgomery, GW, Tiemeier, H.W., Hartikainen, AL, Madden, PAF, d'Adamo, P,
Hastie, ND, Gyllensten, U, Wright, AF, Duijn, C.M. van, Dunlop, M, Rudan, I, Gasparini, P, Pramstaller,
P.P., Deary, IJ, Toniolo, D., Eriksson, JG, Jula, A, Raitakari, OT, Metspalu, A, Perola, M, Jarvelin, MR,
Uitterlinden, A., Visscher, P.M. & Wilson, JF (2012). Evidence of Inbreeding Depression on Human
Height. PLoS Genetics, 8(7).
Medici, M., Rijke, Y.B. de, Peeters, R.P., Visser, W., Muinck Keizer-Schrama, S.M.P.F., Jaddoe,
V.W.V.K., Hofman, A., Hooijkaas, H., Steegers, E.A.P., Tiemeier, H.W., Schokking, J.J. & Visser, T.J.
(2012). Maternal early pregnancy and newborn thyroid hormone parameters: The Generation R Study.
Journal of Clinical Endocrinology and Metabolism, 97(2), 646-652.
Micali, N, Stavola, B De, dos-Santos-Silva, I, Graaff, J. de, Jansen, P.W., Jaddoe, V.W.V.K., Hofman, A.,
Verhulst, F.C., Steegers, E.A.P. & Tiemeier, H.W. (2012). Perinatal outcomes and gestational weight
Erasmus MC – Research Annual Report 2012
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gain in women with eating disorders: a population-based cohort study. Bjog-An International Journal of
Obstetrics and Gynaecology, 119(12), 1493-1502.
Mieloo, C.L., Raat, H., Oort, F.V.A. van, Bevaart, F., Vogel, I., Donker, M. & Jansen, W. (2012). Validity
and Reliability of the Strengths and Difficulties Questionnaire in 5-6 Year Olds: Differences by Gender or
by Parental Education? PLoS One, 7(5).
Mil, N.H. van, Tiemeier, H.W., Bongers-Schokking, J.J., Ghassabian, A., Hofman, A., Hooijkaas, H.,
Jaddoe, V.W.V.K., Muinck Keizer-Schrama, S.M.P.F., Steegers, E.A.P., Visser, T.J., Visser, W.E., Ross,
H.A., Verhulst, F.C., Rijke, Y.B. de & Steegers-Theunissen, R.P.M. (2012). Low Urinary Iodine Excretion
during Early Pregnancy Is Associated with Alterations in Executive Functioning in Children. Journal of
Nutrition, 142(12), 2167-2174.
Mil, N.H. van, Steegers-Theunissen, R.P.M., Bongers-Schokking, J.J., Marroun, H El, Ghassabian, A.,
Hofman, A., Jaddoe, V.W.V.K., Visser, T.J., Verhulst, F.C., Rijke, Y.B. de, Steegers, E.A.P. & Tiemeier,
H.W. (2012). Maternal Hypothyroxinemia During Pregnancy and Growth of the Fetal and Infant Head.
Reproductive Sciences, 19(12), 1315-1322.
Monshouwer, K., Smit, F., Ruiter, M. de, Ormel, H, Verhulst, F.C., Vollebergh, W. & Oldehinkel, A.J.
(2012). Identifying target groups for the prevention of depression in early adolescence: The TRAILS
study. Journal of Affective Disorders, 138(3), 287-294.
Monshouwer, K., Harakeh, Z, Lugtig, P., Huizink, A.C., Creemers, H.E., Reijneveld, S.A., Winter, A.F. de,
Oort, F.V.A. van, Ormel, J. & Vollebergh, W.A.M. (2012). Predicting Transitions in Low and High Levels
of Risk Behavior from Early to Middle Adolescence: The TRAILS Study. Journal of Abnormal Child
Psychology, 40(6), 923-931.
Nederhof, E, Jorg, F, Raven, D, Veenstra, R., Verhulst, F.C., Ormel, J. & Oldehinkel, A.J. (2012).
Benefits of extensive recruitment effort persist during follow-ups and are consistent across age group
and survey method. The TRAILS study. BMC Medical Research Methodology, 12.
Nijs, I.M.T. & Franken, I.H.A. (2012). Attentional Processing of Food Cues in Overweight and Obese
Individuals. Current Obesity Reports, 1, 106-113.
Oort, F.V.A. van, Ormel, J. & Verhulst, F.C. (2012). Angstsymptomen bij adolescenten; bevindingen uit
de trails-studie. Tijdschrift voor Psychiatrie, 54, 463-469.
Opic, P., Utens, E.M.W.J., Moons, P., Theuns, D.A.M.J., Dijk, APJ van, Hoendermis, ES, Vliegen, H.W.,
Groot, N.M.S. de, Witsenburg, M., Schalij, M & Roos-Hesselink, J.W. (2012). Psychosocial impact of
implantable cardioverter defibrillators (ICD) in young adults with Tetralogy of Fallot. Clinical Research in
Cardiology, 101(7), 509-519.
Ormel, J., Oldehinkel, A.J., Sijtsema, J, Oort, F.V.A. van, Raven, D, Veenstra, R., Vollebergh, W.A.M. &
Verhulst, F.C. (2012). The TRacking Adolescents' Individual Lives Survey (TRAILS): Design, Current
Status, and Selected Findings. Journal of the American Academy Child Adolescent Psychiatry, 51(10),
1020-1036.
Pender, A.M.G. de, Berg, M.P. van den & Raats, M.E. (2012). Obsessieve-compulsieve stoornis tijdens
de zwangerschap en post-partumperiode. Tijdschrift voor Psychiatrie, 54(6), 549-553.
Quispel, C., Schneider, T.A.J., Bonsel, G.J. & Berg, M.P. van den (2012). An innovative
screen-and-advice model for psychopathology and psychosocial problems among urban pregnant
women: an exploratory study. Journal of Psychosomatic Obstetrics and Gynecology, 33(1), 7-14.
Raznahan, A, Lee, Y., Vaituzis, C, Tran, L, Mackie, S, Tiemeier, H.W., Clasen, L, Lalonde, F, Greenstein,
D, Pierson, R & Giedd, JN (2012). Allelic Variation Within the Putative Autism Spectrum Disorder Risk
Erasmus MC – Research Annual Report 2012
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Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents.
Autism Research, 5(2), 93-100.
Rescorla, LA, Achenbach, T.M., Ivanova, MY, Bilenberg, N, Bjarnadottir, G, Denner, S, Dias, P, Dobrean,
A, Dopfner, M, Frigerio, A, Goncalves, M, Guomundsson, H, Jusiene, R, Kristensen, S., Lecannelier, F,
Leung, P.W.L., Liu, JH, Lobel, SP, Machado, BC, Markovic, J, Mas, PA, Esmaeili, EM, Montirosso, R,
Pluck, J, Pronaj, AA, Rodriguez, JT, Rojas, PO, Schmeck, K, Shahini, M, Silva, JR, Ende, J. van der &
Verhulst, F.C. (2012). Behavioral/Emotional Problems of Preschoolers: Caregiver/Teacher Reports From
15 Societies. Journal of Emotional and Behavioral Disorders, 20(2), 68-81.
Rijlaarsdam, J., Stevens, G.W.J.M., Ende, J. van der, Arends, L.R., Hofman, A., Jaddoe, V.W.V.K.,
Mackenbach, J.P., Verhulst, F.C. & Tiemeier, H.W. (2012). A brief observational instrument for the
assessment of infant home environment: development and psychometric testing. International Journal
of Methods in Psychiatric Research, 21(3), 195-204.
Robbers, S.C.C., Oort, F.V.A. van, Huizink, A.C., Verhulst, F.C., Beijsterveldt, C van, Boomsma, D &
Bartels, M. (2012). Childhood problem behavior and parental divorce: evidence for gene-environment
interaction. Social Psychiatry and Psychiatric Epidemiology, 47(10), 1539-1548.
Silva, L.M., Rossem, L. van, Jansen, P.W., Hokken-Koelega, A.C.S., Moll, H.A., Hofman, A.,
Mackenbach, J.P., Jaddoe, V.W.V.K. & Raat, H. (2012). Children of Low Socioeconomic Status Show
Accelerated Linear Growth in Early Childhood; Results from the Generation R Study. PLoS One, 7(5).
Sui, J., He, H., Pearlson, GD, Adali, T, Kiehl, KA, Yu, Q, Clark, VP, Castro, E., White, T.J.H., Mueller, BA,
Ho, BC, Andreasen, N.C. & Calhoun, VD (2012). Three-way (N-way) fusion of brain imaging data based
on mCCA+jICA and its application to discriminating schizophrenia. Neuroimage, 66, 119-132.
Tharner, A., Luijk, P.C.M., Raat, H., Ijzerdoorn, M.H. van, Bakermans-Kranenburg, MJ, Moll, H.A.,
Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2012). Breastfeeding and Its Relation
to Maternal Sensitivity and Infant Attachment. Journal of Developmental and Behavioral Pediatrics,
33(5), 396-404.
Tharner, A., Luijk, P.C.M., Ijzerdoorn, M.H. van, Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K.,
Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2012). Infant Attachment, Parenting Stress, and Child
Emotional and Behavioral Problems at Age 3 Years. PARENTING-SCIENCE AND PRACTICE, 12(4),
261-281.
Tharner, A., Luijk, P.C.M., Ijzerdoorn, M.H. van, Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K.,
Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2012). Maternal lifetime history of depression and
depressive symptoms in the prenatal and early postnatal period do not predict infant-mother
attachment quality in a large, population-based Dutch cohort study. ATTACHMENT & HUMAN
DEVELOPMENT, 14(1), 63-81.
Tiemeier, H.W., Velders, F.P., Szekely, E., Roza, S.J., Dieleman, G.C., Jaddoe, V.W.V.K., Uitterlinden,
A.G., White, T.J.H., Bakermans-Kranenburg, MJ, Hofman, A., IJzendoorn, M.H. van, Hudziak, J.J. &
Verhulst, F.C. (2012). The Generation R Study: A Review of Design, Findings to Date, and a Study of the
5-HTTLPR by Environmental Interaction From Fetal Life Onward. Journal of the American Academy
Child Adolescent Psychiatry, 51(11), 1119-1135.
Velders, F.P., Wit, JE De, Jansen, P.W., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W.
(2012). FTO at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in
Preschool Children. PLoS One, 7(11).
Velders, F.P., Dieleman, G.C., Cents, R.A.M., Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K., Hofman,
A., Ijzerdoorn, M.H. van, Verhulst, F.C. & Tiemeier, H.W. (2012). Variation in the Glucocorticoid
Receptor Gene at rs41423247 Moderates the Effect of Prenatal Maternal Psychological Symptoms on
Child Cortisol Reactivity and Behavior. Neuropsychopharmacology, 37(11), 2541-2549.
Erasmus MC – Research Annual Report 2012
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Verheij, F. (2012). Comeback van de (kinder- en jeugd)psychotherapie: doorstart of stuiptrekking?
Kinder- en jeugdpsychotherapie, 39(1), 6-20.
Verheij, F. (2012). Ouderschap, vanzelfsprekend een zoektocht! Een ontwikkelingspsychologisch
perspectief. Kinder- en jeugdpsychotherapie, 39(4), 5-16.
Verlinden, M., Tiemeier, H.W., Hudziak, J.J., Jaddoe, V.W.V.K., Raat, H., Guxens, M, Hofman, A.,
Verhulst, F.C. & Jansen, P.W. (2012). Television Viewing and Externalizing Problems in Preschool
Children The Generation R Study. Archives of Pediatrics & Adolescent Medicine, 166(10), 919-925.
Visser, A.M., Jaddoe, V.W.V.K., Ghassabian, A., Schenk, J.J.A.M., Verhulst, F.C., Hofman, A., Tiemeier,
H.W., Moll, H.A. & Arts, W.F.M. (2012). Febrile seizures and behavioural and cognitive outcomes in
preschool childrenL the Generation R Study. Developmental Medicine & Child Neurology, 54,
1006-1011.
Visser, K, Greaves-Lord, K., Dekker, L., Boudesteijn, F., Maras, A. & Vegt, E.J.M. van der (2012). Ik
Puber. Een onderzoek naar de effectiviteit van de Ik puber-training. Wetenschappelijk Tijdschrift
Autisme, 2, 64-67.
Vlugt, J.J.B. van der, Meulen, J.J.N.M. van der, Creemers, H.E., Verhulst, F.C., Hovius, S.E.R. &
Okkerse, J.M.E. (2012). Cognitive and Behavioral Functioning in 82 Patients with Trigonocephaly.
Plastic and Reconstructive Surgery, 130(4), 885-893.
Vreeke, L.J., Muris, P., Mayer, B., Huijding, J., Bos, A.E.R., Keijzer-Veen, M.G., Raat, H. & Verheij, F.
(2012). The assessment of an inhibited, anxiety-prone temperament in a Dutch multi-ethnic population
of preschool children. European Child & Adolescent Psychiatry, 21(11), 623-633.
Vuijk, R., Nijs, P.F.A. de, Vitale, S.G., Simons-Sprong, M. & Hengeveld, M.W. (2012).
Persoonlijkheidsaspecten bij volwassenen met autismespectrumstoornissen gemeten met de
Temperament and Character Inventory (TCI). Tijdschrift voor Psychiatrie, 54(8), 699-707.
White, T.J.H., Moeller, S, Schmidt, M., Pardo, JV & Olman, C (2012). Evidence for intact local
connectivity but disrupted regional function in the occipital lobe in children and adolescents with
schizophrenia. Human Brain Mapping, 33(8), 1803-1811.
Wielemaker, J.F. & Verheij, F. (2012). Probleemgedrag bij jongens en meisjes met een
autismespectrumstoornis in de kindertijd en de volwassenheid. Wetenschappelijk Tijdschrift Autisme,
11, 39-46.
Wigman, JTW, Winkel, R van, Ormel, J., Verhulst, F.C., Os, J. van & Vollebergh, W.A.M. (2012). Early
trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta
Psychiatrica Scandinavica, 126(4), 266-273.
Wijtzes, A.I., Jansen, W., Kamphuis, C.B.M., Jaddoe, V.W.V.K., Moll, H.A., Tiemeier, H.W., Verhulst,
F.C., Hofman, A., Mackenbach, J.P. & Raat, H. (2012). Increased risk of exceeding
entertainment-media guidelines in preschool children from low socioeconomic background: The
Generation R Study. Preventive Medicine, 55, 325-329.
Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Jaddoe, V.W.V.K., Hofman, A., Raat, H., Verhulst, F.C.,
Passchier, J. & Tiemeier, H.W. (2012). Concurrent and Longitudinal Bidirectional Relationships Between
Toddlers' Chronic Pain and Mental Health: The Generation R Study. Journal of Pediatric Psychology,
37(5), 546-556.
Zwirs, B, Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Mackenbach, J.P. & Tiemeier, H.W. (2012).
Partner similarity for self-reported antisocial behaviour among married, cohabiting and dating couples:
the Generation R Study. Psychology Crime & Law, 18(4), 335-349.
Part of book - Abstract
Erasmus MC – Research Annual Report 2012
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Beusekom, B.S. van (2012). Kinderen en jeugdigen met een ontwikkelingsstoornis of disruptieve
stoornis in het algemene ziekenhuis. In EAF van Weel, MHM van Lier & F. Verheij (Eds.), Consultatieve
en liaison kinder- en jeugdpsychiatrie (pp. 309-321). Assen: Van Gorcum.
Dulfer, K., Helbring, W.A. & Utens, E.M.W.J. (2012). Coping in Parents of Children with Congenital
Heart Disease. In BMV Grimaldo (Ed.), Handbook of the Psychology of Coping: New Research (pp.
307-320). Haupage NY: Nova Science.
Lier, M.H.M. van & Weel, EAF van (2012). Context voor consultatie. In EAF van Weel, MHM van Lier & F
Verheij (Eds.), Consultatieve en liaison kinder- en jeugdpsychiatrie (pp. 325-350). Assen: Van Gorcum.
Lier, M.H.M. van & Theil, A.C. (2012). Somatoforme stoornissen. In EAF van Weel, MHM van Lier & F
Verheij (Eds.), Consultatieve en liaison kinder- en jeugdpsychiatrie (pp. 229-254). Assen: Van Gorcum.
Lier, M.H.M. van (2012). Voedings- en eetstoornissen bij zuigelingen en peuters. In EAF van Weel, HMH
van Lier & F Verheij (Eds.), Consultatieve en liaison kinder- en jeugdpsychiatrie (pp. 203-226). Assen:
Van Gorcum.
Utens, E.M.W.J., Rijen, E.H.M. van & Opic, P. (2012). Quality of life and psychosocial functioning in
adults with congenital heart disease (review). In Pediatric Cardiovascular Medicine (pp. 54). --: Wiley
Blackwell.
Verheij, F., Weel, EAF van & Lier, M.H.M. van (2012). Kind, gezin, ziekte en ziekenhuis. In EAF van
Weel, MHM van Lier & 'F Verheij (Eds.), Consultatieve en liaison kinder- en jeugdpsychiatrie (pp. 3-34).
Assen: Van Gorcum.
Verheij, F. & Reichart, C.G. (2012). Kinderpsychiatrische stoornissen in de adolescentie. In L
Pepplinkhuizen, JMA Sitsen & WMA Verhoeven (Eds.), Het psychiatrisch formularium, Vol. 7e editie (pp.
203-216). Houten: Bohn Stafleu van Loghum.
Verheij, F. & Hofstra, M.B. (2012). Psychiatrische stoornissen van de kindertijd. In C Blanken, W
Garenfeld, I te Paske & M van Piere (Eds.), Psychiatrie voor SPH (pp. 445-460). Amsterdam: Reed
Business.
Verheij, F. & Lier, M.H.M. van (2012). Psychotherapie in de pediatrische setting. In EAF van Weel, MHM
van Lier & F Verheij (Eds.), Consultatieve en liaison kinder- en jeugdpsychiatrie (pp. 377-393). Assen:
Van Gorcum.
Book Editorship
Weel, EAF van, Lier, M.H.M. van & Verheij, F. (Eds.). (2012). Consultatieve en liaison kinder- en
jeugdpsychiatrie. Assen: Van Gorcum.
White, T.J.H. (Ed.). (2012). De Hersenoze Prinses. Rotterdam: Optima Grafische Communicatie.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-04-56-01 - Adaptation of (future) patients to disease and treatment in order
to improve counselling and guidance
Programme (brief description)
This programme investigates the emotional response to disease and treatment, and the ways to
influence these emotions positively. The programme is part of NIHES and carried out with many
clinical departments of the Erasmus MC.
Key Figures
Department
cardiology
medical
psychology &
psychotherapy
Sp1
2,8
Sp2
2
rehabilitation
Sp3
Sp4
2,5
Total
0,2
0,2
5
12,3
0,2
rheumatology
2,8
2
2,7
SpTot
T1
T2
T3
Ttot
IS
FS
OP
0,2
0,5
0,5
5,7
13,2
2
0
0
2
24
1
3
Thesis
Feenstra, D.J. (2012, oktober 17). Personality disorders in adolescents: prevalence, burden,
assessment, and treatment. EUR (165 pag.). Prom./coprom.: Prof.dr. J.J. van Busschbach & R. Verheul.
Heijer, M. den (2012, juni 13). As time goes by the long-term psychological impact of either regular
surveillance or prophylactic mastectomy in women at risk for hereditary breast cancer. EUR (158 pag.).
Prom./coprom.: A. Tibben & Dr. C.M. Seynaeve.
Article/Letter to the editor
Bales, D., Beek, N. van der, Smits, M., Willemsen, S.P., Busschbach, J.J. van, Verheul, R. & Andrea, H.
(2012). TREATMENT OUTCOME OF 18-MONTH, DAY HOSPITAL MENTALIZATION-BASED TREATMENT
(MBT) IN PATIENTS WITH SEVERE BORDERLINE PERSONALITY DISORDER IN THE NETHERLANDS.
Journal of Personality Disorders, 26(4), 568-582.
Beerthuizen, A., Stronks, D.L., Spijker, A. van t, Yaksh, A., Hanraets, BM, Klein, J. & Huygen, F.J.P.M.
(2012). Demographic and medical parameters in the development of complex regional pain syndrome
type 1 (CRPS1): Prospective study on 596 patients with a fracture. Pain, 153(6), 1187-1192.
Darlington, A.S., Verhulst, F.C., Winter, A.F. de, Ormel, J., Passchier, J. & Hunfeld, J.A.M. (2012). The
influence of maternal vulnerability and parenting stress on chronic pain in adolescents in a general
population sample: The TRAILS study. European Journal of Pain-London, 16(1), 150-159.
Ebrahim, S, Montoya, L, Truong, W, Hsu, S, Din, MK el, Carrasco-Labra, A, Busse, JW, Walter, SD,
Heels-Ansdell, D, Couban, R, Patelis-Siotis, I, Bellman, M, Graaf, L.E. de, Dozois, DJA, Bieling, PJ &
Guyatt, GH (2012). Effectiveness of Cognitive Behavioral Therapy for Depression in Patients Receiving
Disability Benefits: A Systematic Review and Individual Patient Data Meta-Analysis. PLoS One, 7(11).
Feenstra, D.J., Hutsebaut, J., Laurenssen, E.M.P., Verheul, R., Busschbach, J.J. van & Soeteman, D.I.
(2012). THE BURDEN OF DISEASE AMONG ADOLESCENTS WITH PERSONALITY PATHOLOGY:
QUALITY OF LIFE AND COSTS. Journal of Personality Disorders, 26(4), 593-604.
Heijer, M. den, Seynaeve, C., Timman, R., Duivenvoorden, H.J., Vanheusden, K., Tilanus-Linthorst, M.,
Menke-Pluijmers, MBE & Tibben, A. (2012). Body image and psychological distress after prophylactic
mastectomy and breast reconstruction in genetically predisposed women: A prospective long-term
follow-up study. European Journal of Cancer, 48(9), 1263-1268.
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Heijer, M. den, Vos, J. de, Seynaeve, C., Vanheusden, K., Duivenvoorden, H.J., Tilanus-Linthorst, M.,
Menke-Pluymers, M.B.E. & Tibben, A. (2012). The impact of social and personal resources on
psychological distress in women at risk for hereditary breast cancer. Psycho-Oncology, 21(2), 153-160.
Hout, B. van, Janssen, M.F., Feng, YS, Kohlmann, T., Busschbach, J.J. van, Golicki, D, Lloyd, A, Scalone,
L., Kind, P. & Pickard, A.S. (2012). Interim Scoring for the EQ-5D-5L: Mapping the EQ-5D-5L to
EQ-5D-3L Value Sets. Value in Health, 15(5), 708-715.
Hunfeld, J.A.M. & Passchier, J. (2012). Participation in medical research; a systematic review of the
understanding and experience of children and adolescents. Patient Education and Counseling, 87(3),
268-276.
Hutsebaut, J., Bales, DL, Busschbach, J.J. van & Verheul, R. (2012). The implementation of
mentalization-based treatment for adolescents: a case study from an organizational, team and therapist
perspective. INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS, 6.
Ismail, S.Y., Massey, E., Luchtenburg, A.E., Claassens, C.T.J., Zuidema, W., Busschbach, J.J. van &
Weimar, W. (2012). Religious attitudes towards living kidney donation among Dutch renal patients.
Medicine, Health Care and Philosophy, 15(2), 221-227.
Janssen, R. & Busschbach, J.J. van (2012). Op weg naar gepaste geestelijke gezondheidszorg.
Economisch-Statistische Berichten, 46445, 81-86.
Janssens, KAM, Oldehinkel, A.J., Verhulst, F.C., Hunfeld, J.A.M., Ormel, J. & Rosmalen, J..G.M. (2012).
Symptom-specific associations between low cortisol responses and functional somatic symptoms: The
TRAILS study. Psychoneuroendocrinology, 37(3), 332-340.
Jong, K. de, Sluis, P. van, Nugter, M.A., Heiser, W. J. & Spinhoven, P. (2012). Understanding the
differential impact of outcome monitoring: Therapist variables that moderate feedback effects in a
randomized clinical trial. Psychotherapy Research, 22(4), 464-474.
Manen, JG van, Kamphuis, JH, Goossensen, A, Timman, R., Busschbach, J.J. van & Verheul, R. (2012).
IN SEARCH OF PATIENT CHARACTERISTICS THAT MAY GUIDE EMPIRICALLY BASED TREATMENT
SELECTION FOR PERSONALITY DISORDER PATIENTS-A CONCEPT MAP APPROACH. Journal of
Personality Disorders, 26(4), 481-497.
Niet, J.E. de, Timman, R., Bauer, S, Akker, E.L.T. van den, Klerk, C. de, Kordy, H & Passchier, J. (2012).
Short Message Service Reduces Dropout in Childhood Obesity Treatment: A Randomized Controlled
Trial. Health Psychology, 31(6), 797-805.
Niet, J.E. de, Timman, R., Bauer, S, Akker, E.L.T. van den, Buijks, H.I.M., Klerk, C. de, Kordy, H &
Passchier, J. (2012). The effect of a short message service maintenance treatment on body mass index
and psychological well-being in overweight and obese children: a randomized controlled trial. Pediatric
Obesity, 7(3), 205-219.
Raaf, P.J. de, Klerk, C. de, Timman, R., Hinz, A & Rijt, C.C.D. van der (2012). Differences in Fatigue
Experiences Among Patients With Advanced Cancer, Cancer Survivors, and the General Population.
Journal of Pain and Symptom Management, 44(6), 823-830.
Schawo, S.J., Eeren, H. van, Soeteman, D.I., Veldt, M.C. van der, Noom, M.J., Brouwer, W.B.F.,
Busschbach, J.J. van & Hakkaart-van Roijen, L. (2012). Framework for Modelling the Cost-effectiveness
of Systemic Interventions Aimed to Reduce Youth Delinquency. The Journal of Mental Health Policy and
Economics, 15, 187-196.
Stel, H.F. van, Busschbach, J.J. van, Hunink, M.G.M. & Buskens, E. (2012). Impact of Secondary
Cardiovascular Events on Health Status. Value in Health, 15(1), 175-182.
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Verwoerd, J.H., Luijsterburg, P.A.J., Timman, R., Koes, B.W. & Verhagen, A.P. (2012). A single question
was as predictive of outcome as the Tampa Scale for Kinesiophobia in people with sciatica: an
observational study. JOURNAL OF PHYSIOTHERAPY, 58(4), 249-254.
Vissers, M.M., Bussmann, J.B.J., Verhaar, J.A.N., Busschbach, J.J. van, Bierma-Zeinstra, S.M.A. &
Reijman, M. (2012). Psychological Factors Affecting the Outcome of Total Hip and Knee Arthroplasty: A
Systematic Review. Seminars in Arthritis and Rheumatism, 41(4), 576-588.
Weel-Baumgarten, EM van, Brouwers, M, Grosfeld, F, Hermus, FJ, Dalen, J. van & Bonke, B. (2012).
Teaching and training in breaking bad news at the Dutch medical schools: A comparison. Medical
Teacher, 34(5), 373-381.
Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Jaddoe, V.W.V.K., Hofman, A., Raat, H., Verhulst, F.C.,
Passchier, J. & Tiemeier, H.W. (2012). Concurrent and Longitudinal Bidirectional Relationships Between
Toddlers' Chronic Pain and Mental Health: The Generation R Study. Journal of Pediatric Psychology,
37(5), 546-556.
Zonneveld, L.N.L., Rood, YR van, Timman, R., Kooiman, C.G., Spijker, A. van t & Busschbach, J.J. van
(2012). Effective Group Training for Patients with Unexplained Physical Symptoms: A Randomized
Controlled Trial with a Non-Randomized One-Year Follow-Up. PLoS One, 7(8).
Zonneveld, L.N.L., Rood, YR van, Kooiman, C.G., Timman, R., Spijker, A. van t & Busschbach, J.J. van
(2012). Predicting the outcome of a cognitive-behavioral group training for patients with unexplained
physical symptoms: a one-year follow-up study. Bmc Public Health, 12(848).
Zonneveld, L.N.L., Spijker, A. van t & Busschbach, J.J. van (2012). Bevorderen van gepaste zorg voor
patienten met onverklaarde lichamelijke klachten: een voorbeeld. GZ - Psychologie.
Part of book - Abstract
Soeteman, D.I. & Busschbach, J.J. van (2012). Kosteneffectiviteit van behandeling. In T Ingenhoven, A
van Reekum, B van Luyn & P Luyten (Eds.), Handboek borderline persoonlijksheidsstoornis. Utrecht: De
Tijdstroom.
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EMC NIHES-05-63-01 - Management and organisation of health care delivery
Programme (brief description)
This research line focuses on the social, legal and organisational aspects of management of
professional knowledge, quality systems, information and communication technology in health
care and health care management. The programme aims to translate theories of organisation,
management and policy into practical guidelines and recommendations for health care
organisations. Case studies are undertaken to gain insight in the dynamics of inter- and
intra-organisational networks and in opportunities for network management. Special emphasis is
put on the quality and accessibility of health care for ethnic minorities. Finally the programme
evaluates effects of new health care legislation.
Key Figures
Department
Health Care
Governance
Management &
Organisatie van
Zorgverlening
(HSMO)
Total
Sp1
Sp2
Sp3
Sp4
SpTot
0,98
0,4
0,89
2,27
2,31
4,29
5,23
11,83
3,29
4,69
6,12
14,1
0
T1
T2
T3
Ttot
IS
FS
OP
Ptot
3
0
0
3
31
7
4
45
Article/Letter to the editor
Baarsma, B., Kam, F. de, Linschoten, R. van, Verloren Van Themaat, W. & Varkevisser, M. (2012).
Opereren binnen zorguitgavenkaders. Economisch-Statistische Berichten, 97(4638), 408-411.
Cramm, J.M., Hartgerink, J.M., Vreede, P.L. de, Bakker, T.J., Steyerberg, E.W., Mackenbach, J.P. &
Nieboer, A.P. (2012). The relationship between older adults' self-management abilities, well-being and
depression. European Journal of Ageing, 9, 353-360.
Cramm, J.M., Strating, M.M.H., Vreede, P.L. de, Steverink, N. & Nieboer, A.P. (2012). Validation of the
self-management ability scale (SMAS) and development and validation of a shorter scale (SMAS-S)
among older patients shortly after hospitalisation. Health and Quality of Life Outcomes, 10(9), 1-7.
Dirks, M., Niessen, L.W., Wijngaarden, J. van, Koudstaal, P.J., Franke, C.L., Oostenbrugge, RJ van &
Dippel, D.W.J. (2012). The effectiveness of thrombolysis with intravenous alteplase for acute ischemic
stroke in daily practice. International Journal of Stroke, 7(4), 289-292.
Hartgerink, J.M., Cramm, J.M., Bakker, T.J.E.M., Eijsden, R.A.M. van, Mackenbach, J.P. & Nieboer, A.P.
(2012). The importance of relational coordination for integrated care delivery to older patients in the
hospital. Journal of Nursing Management, 1-9.
Henken, K.R., Jansen, F.W., Klein, J., Stassen, L.P.S., Dankelman, J & Dobbelsteen, J van den (2012).
Implications of the law on video recording in clinical practice. Surgical Endoscopy, 26, 2909-2916.
Korne, D.F. de, Wijngaarden, J.D.H. van, Van Rooij, J., Wauben, L.S.G.L., Hiddema, U.F. & Klazinga,
N.S. (2012). Safety by design: effects of operating room floor marking on the position of surgical
devices to promote clean air flow compliance and minimise infection risks. BMJ Quality & Safety, 21,
746-752.
Mul, M. de, Alons, P.W.F., Velde, M.P. van der, Konings, I.R.H.M., Bakker, J. & Hazelzet, J (2012).
Development of a clinical data warehouse from an intensive care clinical information system. Computer
Methods and Programs in Biomedicine, 105, 22-30.
Erasmus MC – Research Annual Report 2012
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Oostrum, J.M. van, Parlevliet, T., Wagelmans, A.P.M. & Kazemier, G. (2012). A Method for Clustering
Surgical Cases to Allow Master Surgical Scheduling. Infor, 49(4), 254-260.
Poeran, J, Denktas, S., Birnie, E., Weg, E.J. van der, Voorham, T, Steegers, E.A.P. & Bonsel, G.J.
(2012). Zwangerschap en geboorte in Rotterdam: een lokale gezondheidsrapportage. Tijdschrift voor
Gezondheidswetenschappen, 90(8), 496-503.
Temel, S., Birnie, E., Sonneveld, H.M., Voorham, A.J.J., Bonsel, G.J., Steegers, E.A.P. & Denktas, S.
(2012). Determinants of the intention of preconception care use: lessons from a multi-ethnic population
in the Netherlands. International Journal of Public Health, 1-10.
Tuijn, S., Janssens, F., Robben, P.B.M. & Bergh, M.M.H. van den (2012). Reducing interrater variability
and improving health care:a meta-analytical review. Journal of Evaluation in Clinical Practice, 18,
887-895.
Report
Glorie, K.M., Klerk, M. de, Wagelmans, A.P.M., Klundert, J.J. van de, Zuidema, R.J., Claas, F.H.J. &
Weimar, W. (2012). Unspecified donation in kidney exchange: when to end the chain. (EI report
reeksEI 2012-19 ). Rotterdam: Econometric Institute.
Erasmus MC – Research Annual Report 2012
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EMC NIHES-05-63-02 - Quality and efficiency in health care
Programme (brief description)
The programme health technology assessment, which is organised and carried out within iMTA,
has grown considerably in the period '97/2004. An important impetus at the start of the
development in this period was a large grant from the Ministry of Health for iMTA to support
medical associations in their development of practice guidelines. In these guidelines for medical
practice not only effectiveness but also the cost-effectiveness of various preventive or curative
strategies is considered when making recommendations on how to deal with a specific health
problem. Furthermore, important methodological topics have been studied, such as the
measurement and valuation of productivity costs, the analysis of models describing patients'
preferences, the valuation of informal care in economic evaluation, statistical methods of
economic evaluation, efficacy-effectiveness issues, and valuation of quality of life. The
NWO-subprogram on methodology of 'health technology assessment' as part of the larger
program on cost effectiveness of health care programs provided the opportunity to carry out new
methodological projects. Furthermore, a large number of practical, often international, projects
have been carried out for various diseases and health care programs. An innovative example is a
large multinational trial on the management of BPH-treatment in 6 European countries. This is
the first large-scale naturalistic prospective economic evaluation in Europe. Finally, a number of
projects in low-income countries have been carried out, some of which in close cooperation with
WHO Geneva. Almost 100% of the research in this programme is externally funded.
Key Figures
Department
Sp1
Sp2
Sp3
Sp4
SpTot
Gezondheidseconomie-iMTA
(GE-iMTA)
Health Care
Governance
5,49
8,27
18,47
32,23
0,2
0,11
0,7
1,01
Total
5,69
8,38
19,17
33,24
0
T1
3
T2
0
T3
Ttot
0
3
IS
86
FS
OP
17
14
Article/Letter to the editor
Battes, L, Kardys, I., Barendse, R., Steyerberg, E.W., Amiri, M., Eijkemans, M.J.C., Deckers, J.W.,
Postmus, D., Takkenberg, J.J.M., Redekop, W.K. & Boersma, E. (2012). Microsimulation for Clinical
Decision-Making in Individual Patients With Established Coronary Artery Disease. Circulation Journal.
Blommestein, H.M., Verelst, S.G.R., Huijgens, P.C., Blijlevens, N.M.A., Cornelissen, J.J. & Uyl - de Groot,
C.A. (2012). Real-world costs of autologous and allogeneic stem cell transplantations for
haematological diseases: a multicentre study. Annals of Hematology, 91, 1945-1952.
Boormans, E.M.A., Birnie, E., Hoffer, MJV, Macville, M.V.E., Galjaard, R.J.H., Schuring-Blom, G.H.,
Bhola, S.L., Huijsdens, K., Smits, A. & Lith, J.M.M. van (2012). Economic evaluation of multiplex
ligation-dependent probe amplification and karyotyping in prenatal diagnosis: a cost-minimization
analysis. Archives of Gynecology and Obstetrics, 285(1), 67-75.
Boshuizen, H.C., Lhachimi, S.K., Baal, P.H.M. van, Hoogenveen, R.T., Smit, H.A., Mackenbach, J.P. &
Nusselder, W.J. (2012). The DYNAMO-HIA Model: An Efficient Implementation of a Risk Factor/Chronic
Disease Markov Model for Use in Health Impact Assessment (HIA). Demography, 49(4), 1259-1283.
Camejo, R.R., McGrath, C., Herings, R.M.C., Meerding, W.J. & Rutten, F.F.H. (2012). Antihypertensive
Drugs: A Perspective on Pharmaceutical Price Erosion and Its Impact on Cost-Effectiveness. Value in
Health, 15, 381-388.
Chote, A.A., Groot, C.J.M. de, Redekop, K, Hoefman, R, Koopmans, G.T., Jaddoe, V.W.V.K., Hofman,
A., Steegers, E.A.P., Trappenburg, M., Mackenbach, J.P. & Foets, M.M.E. (2012). Differences in Quality
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of Antenatal Care Provided by Midwives to Low-Risk Pregnant Dutch Women in Different Ethnic Groups.
Journal of Midwifery & Womens Health, 57(5), 461-468.
Denktas, S., Bonsel, G.J., Weg, E.J. van der, Voorham, A.J.J., Torij, H.W., Graaf, J.P. de, Wildschut,
H.I.J., Peters, I.A., Birnie, E. & Steegers, E.A.P. (2012). An Urban Perinatal Health Programme of
Strategies to Improve Perinatal Health. Maternal and Child Health Journal, 16, 1553-1558.
Dirks, M., Baeten, S.A., Dippel, D.W.J., Exel, N.J.A. van, Wijngaarden, J.D.H. van, Huijsman, R.,
Koudstaal, P.J. & Niessen, L.W. (2012). Real-life costs and effects of an implementation program to
increase thrombolysis in stroke. Neurology, 79(6), 508-514.
Frederix, G.W.J., Severens, J.L., Hovels, A.M., Raaijmakers, J.A.M. & Schellens, J.H.M. (2012).
Reviewing the Cost-Effectiveness of Endocrine Early Breast Cancer Therapies: Influence of Differences
in Modeling Methods on Outcomes. Value in Health, 15, 94-105.
Gaultney, J.G., Redekop, W.K., Sonneveld, P. & Uyl - de Groot, C.A. (2012). Novel anticancer agents for
multiple myeloma: a review of the evidence for their therapeutic and economic value. Expert Review of
Anticancer Therapy, 12(6), 839-854.
Gaultney, J.G., Franken, M.G., Tan, S.S., Redekop, W.K., Huijgens, P.C., Sonneveld, P. & Uyl - de Groot,
C.A. (2012). Real-world health care costs of relapsed/refractory multiple myeloma during the era of
novel cancer agents. Journal of Clinical Pharmacy and Therapeutics.
Gestel, A. van, Webers, C.A.B., Severens, J.L., Beckers, H.J.M., Jansonius, N.M., Hendrikse, F. &
Schouten, J. (2012). The long-term outcomes of four alternative treatment strategies for primary
open-angle glaucoma. Acta Ophthalmologica, 90, 20-31.
Gestel, A. van, Grutters, J.C., Schouten, J., Webers, C.A.B., Beckers, H.J.M., Joore, M.A. & Severens,
J.L. (2012). The Role of the Expected Value of Individualized Care in Cost-Effectiveness Analyses and
Decision Making. Value in Health, 15, 13-21.
Gils, C.W.M. van, Koopman, M, Mol, L., Redekop, W.K., Uyl - de Groot, C.A. & Punt, C.J.A. (2012).
Adjuvant chemotherapy in stage III colon cancer: Guideline implementation, patterns of use and
outcomes in daily practice in The Netherlands. Acta Oncologica, 51, 57-64.
Groenendijk, A.G., Birnie, E., Roovers, J.P.W. & Bonsel, G.J. (2012). Clinical Study - Contribution of
Primary Pelvic Organ Prolapse to Micturition and Defecation Symptoms. Obstetrics and Gynecology
International, 16, 1553-1558.
Hendriks, M,, Wit, F.W.N.M., Roos, M.T.L., Brewster, L., Akande, T., Beer, I.H. de, Mfinanga, S.G.,
Kahwa, A.M., Gatongi, P., Rooy, G. van, Janssens, W, Lammers, J., Kramer, B., Bonfrer, I.E.J., Gaeb, E.,
Wit, T. de, Lange, J.M.A. & Schultsz, C (2012). Hypertension in Sub-Saharan Africa: Cross-Sectional
Surveys in Four Rural and Urban Communities. PLoS One, 7(3), 1-10.
Herk-Sukel, M.P.P., Lemmens, V.E.P.P., Poll-Franse, L.V. van de, Herings, R.M.C. & Coebergh, J.W.W.
(2012). Record linkage for pharmacoepidemiological studies in cancer patients. Pharmacoepidemiology
and Drug Safety, 21, 94-103.
Hermans, J., Koopmanschap, M.A., Bierma-Zeinstra, S.M.A., Linge, J.H. van, Verhaar, J.A.N., Reijman,
M. & Burdorf, A. (2012). Productivity Costs and Medical Costs Among Working Patients With Knee
Osteoarthritis. Arthritis Care & Research, 64(6), 853-861.
Huijbregts, K.M.L., Jong, F.J. de, Marwijk, H.W.J. van, Beekman, A.T.F., Adèr, H.J., Hakkaart-van
Roijen, L., Unutzer, J & Feltz-Cornelis, C.M. van der (2012). A target-driven collaborative care model for
Major Depressive Disorder is effective in primary care in the Netherlands. A randomized clinical trial
from the depression initiative. Journal of Affective Disorders.
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Kassteele, J. van de, Hoogenveen, R.T., Engelfriet, P.M., Baal, P.H.M. van & Boshuizen, H.C. (2012).
Estimating net transition probabilities from cross-sectional data with application to risk factors in chronic
disease modeling. Statistics in Medicine, 31, 533-543.
Lamkaddem, M., Essink-Bot, M.L., Deville, W., Foets, M.M.E. & Stronks, K. (2012). Perceived
discrimination outside health care settings and health care utilization of Turkish and Moroccan GP
patients in the Netherlands. European Journal of Public Health, 22(4), 473-478.
Landis, S.H., El-Hariry, I.A., Herk-Sukel, M.P.P., Haak, P van den, Janssen-Heijnen, M.L.G., Penning-van
Beest, F.J.A. & Herings, R.M.C. (2012). PREVALENCE AND INCIDENCE OF ACUTE AND CHRONIC
COMORBIDITY IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK.
Pharmacoepidemiology and Drug Safety, 21, 94-103.
Lhachimi, S.K., Nusselder, W.J., Smit, H.A., Baal, P.H.M. van, Baili, P., Bennett, K., Fernandez, E., Kulik,
M.C., Lobstein, T, Pomerleau, J., Mackenbach, J.P. & Boshuizen, H.C. (2012). DYNAMO-HIA-A Dynamic
Modeling Tool for Generic Health Impact Assessments. PLoS One, 7(5), 1-11.
Lötters, F.J.B., Lenoir-Wijnkoop, I., Fardellone, P., Rizzoli, R., Rocher, E. & Poley, M.J. (2012). Dairy
foods and osteoporosis: an example of assessing the health-economic impact of food products.
Osteoporosis International.
Lötters, F.J.B., Carlier, B.E., Bakker, B., Borgers, N., Schuring, M. & Burdorf, A. (2012). The Influence of
Perceived Health on Labour Participation Among Long Term Unemployed. Journal of Occupational
Rehabilitation.
Majer, I.M., Mackenbach, J.P. & Baal, P.H.M. van (2012). Time trends and forecasts of body mass index
from repeated cross-sectional data: a different approach. Statistics in Medicine.
Over, EAB, Wendel-Vos, W, Berg, M., Hamberg-van Reenen, HH, Tariq, L., Hoogenveen, R.T. & Baal,
P.H.M. van (2012). Cost-effectiveness of counseling and pedometer use to increase physical activity in
the Netherlands: a modeling study. Cost Effectiveness and Resource Allocation, 10 (1), 1-7.
Pangalila, R.F., van den Bos, G.A.M., Stam, H.J., Exel, N.J.A. van, Brouwer, W.B.F. & Roebroeck, M.E.
(2012). Subjective caregiver burden of parents of adults with Duchenne. Disability & Rehabilitation,
34(12), 988-996.
Peeters, A., Schouten, J.S.A.G., Severens, J.L., Hendrikse, F., Prins, MH & Webers, C.A.B. (2012).
Latanoprost versus timolol as first choice therapy in patients with ocular hypertension A
cost-effectiveness analysis. Acta Ophthalmologica, 90, 146-154.
Ruiter, R., Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Risk of cancer in patients on insulin glargine
and other insulin analogues in comparison with those on human insulin: results from a large
population-based follow-up study. Diabetologia, 55, 51-62.
Schawo, S.J., Eeren, H. van, Soeteman, D.I., Veldt, M.C. van der, Noom, M.J., Brouwer, W.B.F.,
Busschbach, J.J. van & Hakkaart-van Roijen, L. (2012). Framework for Modelling the Cost-effectiveness
of Systemic Interventions Aimed to Reduce Youth Delinquency. The Journal of Mental Health Policy and
Economics, 15, 187-196.
Tan, S.S., Bakker, J., Hoogendoorn, M.E., Kapila, A., Martin, J.J., Pezzi, A., Pittoni, G., Spronk, P.E.,
Welte, R. & Hakkaart-van Roijen, L. (2012). Direct Cost Analysis of Intensive Care Unit Stay in Four
European Countries: Applying a Standardized Costing Methodology. Value in Health, 15, 81-86.
van der Kooy, J., Poeran, J, Graaf, J.P. de, Birnie, E., Denktas, S., Steegers, E.A.P. & Bonsel, G.J.
(2012). Planned Home Compared With Planned Hospital Births in the Netherlands: Intrapartum and
Early Neonatal Death in Low-Risk Pregnancies. Obstetrics and Gynecology, 119(2), 388-389.
Erasmus MC – Research Annual Report 2012
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Verhoef, T.I., Redekop, W.K., Schie, R.M.F. van, Bayat, S., Daly, A.K., Geitona, M., Haschkebecher, E.,
Hughes, D.A., Kamali, F., Levin, L.A., Manolopoulos, V.G., Pirmohamed, M., Siebert, U., Stingl, J.C.,
Wadelius, M., Boer, A. de & Maitland-van der Zee, A.H. (2012). Cost-effectiveness of pharmacogenetics
in anticoagulation: international differences in healthcare systems and costs. Pharmacogenomics,
13(12), 1405-1417.
Verhoef, T.I., Redekop, W.K., Buikema, M.M., Schalekamp, T., Meer, F.J.M. van der, Cessie, S. le,
Wessels, J.A.M., Schie, R.M.F. van, Boer, A. den, Teichert, M., Visser, L.E. & Zee, A.H. (2012).
Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users.
Journal of Thrombosis and Haemostasis, 10(4), 606-614.
Versteegh, M.M., Leunis, A., Luime, J.J., Boggild, M, Uyl - de Groot, C.A. & Stolk, E.A. (2012). Mapping
QLQ-C30, HAQ, and MSIS-29 on EQ-5D. Medical Decision Making, 32, 554-568.
Zelle, S.G., Nyarko, K.B., Bosu, W.K., Aikins, M, Niëns, L.M., Lauer, J.A., Sepulveda, C.R., Hontelez,
J.A.C. & Baltussen, R (2012). Costs, effects and cost-effectiveness of breast cancer control in Ghana.
Tropical Medicine and International Health, 17(8), 1031-1043.
Part of book - Abstract
Schie, R.M.F. van, Verhoef, T.I., Maitland-van der Zee, A.H., Boer, A. de, Meer, F.J.M. van der,
Redekop, W.K. & Thariani, R. (2012). Future of Pharmacogenetics in Cardiovascular Diseases. In L.
Gallelli (Ed.), Pharmacology (pp. 207-222). Rijeka: InTech.
Report
Franken, M.G., Gaultney, J.G., Blommestein, H.M., Tan, S.S., Gils, C.W.M. van, Huijgens, P.C.,
Sonneveld, P., Redekop, W.K. & Groot, C.A. de (2012). Pilot outcomes research: effects and costs of
bortezomib in relapsed or refractory multiple myeloma. Rotterdam: Erasmus Universiteit Rotterdam GE-iMTA.
Erasmus MC – Research Annual Report 2012
< back to index
EMC NIHES-05-63-03 - Competition and regulation in health care
Programme (brief description)
The programme "structure and finance of health care" has a strong economic perspective as well
as a judicial perspective. Research focuses on some fundamental aspect of the market-oriented
health care reforms that are taking place in the Netherlands as well as in many other countries.
The risk-adjuster "Pharmacy Cost Group", developed by the health economics group, is
considered to be in the forefront of the international risk adjustment research. The Dutch
government has implemented this new risk-adjuster in the Dutch health insurance system in
2002. Research activities are currently dealing with the following topics: structure of health care
systems, legal aspects of health care reform, uncertainty and equilibrium on the market for
health insurers, regulated competition in health care, competition policy, risk adjusted premium
subsidies for health insurance, determinants of consumer choice of health plan, consumer
information, bonuses for GPs, equity in the finance and delivery of health care and the
consequences of the European Union for structure and finance for the Dutch Health care system.
The research programme on "equity in health and health care" focuses on the national and
international assessment of health equity and inequality. The scope of the research activities has
broadened over the period under consideration from the developed world (OECD countries) to
the less developed world. In collaboration with the World Bank the methods for measuring
inequality and inequity have been adapted to low-income countries and equity objectives, and
have been applied to data from a number of developing nations. The measurement methods of
the ECuity Project, which is co-ordinated by the group, have now become adopted as a
worldwide standard for assessing the equity performance of health systems and the
consequences of reforms, as witnessed by their adoption or explicit reference in all major efforts
at system (equity) performance evaluation such as the Rockefeller Foundation's Global Health
Equity Initiative, the WHO's World Health Report, the World Bank's World Development Report
and the OECD's Framework for Health System Performance.
Key Figures
Department
Gezondheidseconomie
-iMTA (GE-iMTA)
Sp1
Sp2
Sp3
Sp4
SpTot
0,65
0,65
Health Care Governance
Recht & Gezondheidszorg (R&G)
Ziektekostenverzekering
(ZKV)
1,08
2,25
5,93
9,26
0,86
0,22
0,05
1,13
3,16
3,26
Total
2,04
9,79
14,3
0,1
2,47
0
T1
T2
5
T3
0
Ttot
0
5
IS
FS
26
13
Article/Letter to the editor
Bakker, D.H. de, Struijs, J.N., Baan, C.B., Raams, J., Wildt, J-E de, Vrijhoef, H.J.M. & Schut, F.T. (2012).
Early Results From Adoption Of Bundled Payment For Diabetes Care In The Netherlands Show
Improvement In Care Coordination. Health Affairs, 31(2), 426-433.
Beerthuizen, A., Stronks, D.L., Spijker, A. van t, Yaksh, A., Hanraets, BM, Klein, J. & Huygen, F.J.P.M.
(2012). Demographic and medical parameters in the development of complex regional pain syndrome
type 1 (CRPS1): Prospective study on 596 patients with a fracture. Pain, 153(6), 1187-1192.
Douven, R., Mocking, L.P.C.M. & Mosca, I. (2012). Zorggebruik en beloning van medisch specialisten.
Economisch-Statistische Berichten, 97(4632), 212-215.
Helder, O.K., Verweij, J.C.M. & Staa, A.L. van (2012). Transition from neonatal intensive care unit to
special care nurseries: Experiences of parents and nurses. Pediatric Critical Care Medicine, 13(3),
305-311.
Erasmus MC – Research Annual Report 2012
OP
39
Ptot
83
< back to index
Leunis, A., Blommestein, H.M., Huijgens, P.C., Blijlevens, N.M.A., Jongen-Lavrencic, M. & Uyl - de
Groot, C.A. (2012). The costs of initial treatment for patients with acute myeloid leukemia in the
Netherlands. Leukemia Research.
Peijl, J van der, Klein, J., Grass, C. & Freudenthal, A. (2012). Design for risk control: The role of usability
engineering in the management of use-related risks. Journal of Biomedical Informatics, 45(4), 795-812.
Sattoe, J.N.T., Staa, A.L. van & Moll, H.A. (2012). The proxy problem anatomized: Child-parent
disagreement in Health Related Quality of Life reports of chronically ill adolescents. Health and Quality
of Life Outcomes, 10(10), 1-13.
Vahedi Nikbakht, C.V.M., Baar, C. van, Baar, F., Boogaard, R., Dekkers, A., Dijk, E. van, Hamming, A.,
Zoon, C., Staa, A.L. van, Voorham, T & Visser, A. (2012). Minder knelpunten in de palliatieve zorg door
implementatie van het Zorgprogramma Palliatieve Eerstelijnszorg (ZPE?). Nederlands-Vlaams
Tijdschrift voor Palliatieve Zorg, 12(3/4), 12-28.
Vos, J.B.M. de, Asmus, K.J.E., Bakker, T.J.E.M., Vreede, P.L. de, Wijngaarden, J.D.H. van, Steyerberg,
E.W., Mackenbach, J.P. & Nieboer, A.P. (2012). Integrated approach to prevent functional decline in
hospitalized elderly: the Prevention and Reactivation Care Program (PReCaP). BMC Geriatrics, 12(7).
Report
Faber, M.J., Aarts, JWM, Eijk, M. van, Vennik, F.D., Breejen, E. den, Putters, K., Kremer, J.A.M. &
Bloem, BR (2012). Het zorgnetwerk van de patiënt. De eerste ervaringen en zichtbare gevolgen voor de
gezondheidszorg. Nijmegen: MijnZorgnet.
Putters, K., Janssen, M.J., Wel, T. van der & Kelder, M.S. (2012). E-health: Face-to-Facebook Over
e-health en zelfredzaamheid van patiënten in de GGZ. Rotterdam: Erasmus Universiteit Rotterdam.
Erasmus MC – Research Annual Report 2012