Indena`s USA Product List

PRODUCTlist
The QUALITY
PHARMACEUTICAL
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
HEALTH - FOOD
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
PERSONAL CARE
Indena’s Personal Care ingredients are REACH registered.
HALAL
certified
E
ECOCERT
validated
KOSHER
certified
C
CEP
granted
OUR mission
At Indena we believe that an in-depth knowledge
in active ingredients derived from botanicals
and the search for excellence at all times are
crucial commitments to serving our customers
in pharmaceuticals, food supplements, foods and
personal care.
Research and production technologies are the
main focus of our mission and the way we create a
“value difference” for our partners. And we’ve got
more than 90 years of experience to prove it.
HEALTH-FOOD INGREDIENTS DISCLAIMERS
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Marketers of finished products containing the ingredients described herein are
responsible for determining whether the claims made for such products are lawful
and in compliance with the laws of the country in which they will market the products.
The ingredients described herein are offered for consideration for use in
supplements, pharmaceuticals and personal care.
PERSONAL CARE INGREDIENTS DISCLAIMER
The ingredients described herein are offered for consideration for
use in personal care products. The information provided describes
historical use, ingredient activity and other information that may be
relevant to their use in such products. How each ingredient would
contribute to a particular product would be formulation specific.
Excellence in botanical derivatives
06 ISOLATED or SEMISYNTHETIC
PURE PRODUCTS
PURE MOLECULES ISOLATED OR DERIVED FROM PLANTS
10 STANDARDIZED, PURIFIED
or OTHER CHARACTERIZED
DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT OF CHARACTERISTIC PRINCIPLES
indena
researches,
develops and
markets
ACTIVE
PRINCIPLES
and INGREDIENTS
DERIVED FROM
EDIBLE and
MEDICINAL
PLANTS
22 CHARACTERIZED, STANDARDIZED
OILY and SOFT EXTRACTS
OILY / SOFT EXTRACTS WITH REPRODUCIBLE CONTENT OF CHARACTERISTIC PRINCIPLES
24 PHYTOSOME
MORE BIOAVAILABLE FORMS OF ACTIVE PRINCIPLES
28 BOTANICAL EXTRACTS with
ORGANOLEPTIC PROPERTIES
ISOLATED or SEMISYNTHETIC
PURE PRODUCTS
PURE MOLECULES ISOLATED OR DERIVED FROM PLANTS
BRAND - English name
Botanical origin
Assay
Biological Activity
Ajmaline
Rauvolfia vomitoria Afz. - Root bark
≥98.0% ≤ 102.0% by HPLC
Antiarrhythmic
Boldine
Peumus boldus Molina - Bark
≥98.5% ≤100.5% by potentiometry
Choleretic
Gloriosa superba L. - Seed
≥97.0% ≤102.0% by potentiometry
Antigout
Colchicine usp
Gloriosa superba L. - Seed
≥94.0% ≤101.0% by HPLC
Antigout
COLCHICINE MICRONIZED
Gloriosa superba L. - Seed
≥94.0% ≤101.0% by HPLC
Antigout
Colchicoside
Gloriosa superba L. - Seed
≥85.0% by HPLC
Chemical intermediate
10-deacetylbaccatin III
Taxus baccata L. - Twig and leaf
≥96.0% by HPLC
Chemical intermediate
DOCETAXEL
Taxus baccata L. - Twig and leaf
≥97% ≤102.0% by HPLC
Antimitotic / Anticancer
Esculoside
Aesculus hippocastanum L. - Bark of branch
≥98.0% by HPLC
Vasokinetic, Capillary protectant
18β-glycyrrhetinic acid EUR. PH.
Glycyrrhiza glabra L.- Root, rhizome
≥98.0% ≤101.0% by acidimetry
Antiinflammatory
18β-glycyrrhetinic acid
Glycyrrhiza glabra L.- Root, rhizome
≥98.0% ≤102.0% by acidimetry
Soothing, Lenitive
Galanthamine BROMIDRATE
Narcissus pseudonarcissus L. - Bulb
≥98.0% ≤102.0% by HPLC
Antialzheimer
Colchicine ph. eur.
C
Paclitaxel
C
Taxus media Rehder - Root, Leaf and Twig
≥97.0% ≤ 102.0% by HPLC
Antimitotic / Anticancer
PACLITAXEL S
C
Taxus baccata (L.) - Leaf and Twig
≥97% ≤102% by HPLC
Antimitotic / Anticancer
PRAJMALINE
Rauvolfia vomitoria Afz. - Root bark
≥98% ≤102% by potentiometry
Antiarrhythmic
RESERPINE
Rauvolfia vomitoria Afz. - Root bark
≥99.0% ≤101.0% by potentiometry
Antihypertensive
Reserpine usp
Rauvolfia vomitoria Afz. - Root bark
≥97.0% ≤101.0% by HPLC
Antihypertensive
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
6
7
ISOLATED or SEMISYNTHETIC
PURE PRODUCTS
PURE MOLECULES ISOLATED OR DERIVED FROM PLANTS
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
Reserpine MICRONIZED
Rauvolfia vomitoria Afz. - Root bark
≥99.0% ≤101.0% by potentiometry
Antihypertensive
Sericoside
Terminalia sericea Burch. ex DC.- Root bark
≥76.0% ≤84.0% by HPLC
Antiwrinkles, Soothing, Redensifier
Thiocolchicoside
Gloriosa superba L. - Seed
≥98.0% ≤102.0% by potentiometry
Muscle relaxant
Thiocolchicoside B
Gloriosa superba L. - Seed
≥98.0% ≤102.0% by potentiometry
Muscle relaxant
Visnadine
Ammi visnaga (L.) Lam - Umbel without fruits
≥90.0% by HPLC
Vasokinetic
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
8
9
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
BRAND - English name
Botanical origin
Assay
Biological Activity
ALDER BUCKTHORN
Frangula alnus Miller (Rhamnus frangula L.) - Bark
≥15% hydroxyanthracene heterosides calculated as glucofrangulin A
Laxative
ARTICHOKE
H
Cynara cardunculus L. - Flowering head, Leaves
≥13.0 ≤18.0% of caffeoylquinic acids by spectrophotometry
Cholesterol and Intestinal health
BILEAR™
K
Cynara cardunculus L. - Leaf
≥0.3% flavonoids expressed as luteolin-7-O-glucoside,
≥2.5% caffeoylquinic acid expressed as chlorogenic acid,
≥0.6% chlorogenic acid by HPLC
Cholesterol and Intestinal health
ARTICHOKE
H
Cynara cardunculus L. - Flowering head, Leaves
≥50.0% of caffeoylquinic acids by HPLC
Cholesterol and Intestinal health
Phaseolus vulgaris L. - Common bean
≥6% as alpha amylase inhibitor by HPLC; 1100 U/mg of alpha amylase
inhibiting activity; 30000 HAU/g of hemagglutinating activity by
spectroph./enzym.
Appetite regulator,
Healthy blood sugar metabolism
BEANBLOCK® - BEAN
MIRTOSELECT® - BILBERRY
H
Vaccinium myrtillus L. - Fresh frozen fruit
≥36.0% of anthocyanins by HPLC; ≥25% anthocyanins
as anthocyanidins by spectrophotometry
Eye health, Circulatory health,
Antioxidant activity
BLACK COHOSH
K
Cimicifuga racemosa (L.) Nutt. - Rhizome and Root
≥5% of total triterpenic glycosides
Menopause-related symptoms controller
BLADDERWRACK
K
Fucus vesiculosus L. - Thallus
≥0.2% of fucosterol by TLC; ≥0.2% of iodine according to DAB method
Weight control agent, Anticellulite
BOLDO
K
Peumus boldus L. - Leaf and bark
≥0.05% of boldin by TLC; ≤0.2% of total alkaloids by acidometry
Liver health
BUTCHER’S BROOM
K
Ruscus aculeatus L. - Rhizome and root
≥9.0% ≤11.0% of saponins calculated as ruscogenins
by spectrophotometry
Circulatory health
CAPE ALOES
K
Aloe ferox L. - Leaf
≥19% ≤21% hydroxyanthracene derivatives expressed as barbaloin
Laxative
Rhamnus purshiana DC.- Bark
≥24.0% ≤26.5% of cascarosides expressed as cascaroside A
by spectrophotometry
Laxative
PURSELECT® - CASANTHRANOL
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
10
11
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
CASCARA SAGRADA
Rhamnus purshiana DC. - Bark
≥20.0% ≤25.0% of cascarosides expressed as cascaroside A
by spectrophotometry
Laxative
Centella asiatica (L.) Urban - Leaf
≥45.0% of the sum of asiaticoside, madecassoside,
asiatic and madecassic acids by HPLC
Collagen restructurant, Antiwrinkles agent
Centella asiatica (L.) Urban - Leaf
≥36.0% ≤44.0% of asiaticoside, ≥56.0% ≤64.0% of genins
as sum of asiatic acid and madecassic acid by HPLC
Antiwrinkles, Skin health, Stretchmarks
improver
Matricaria recutita L. - Flowering head, Leaves
≥1.2% of total apigenin by HPLC
Soothing, Lenitive
Coleus barbatus Benth. - Rhizome and root
≥80.0% of forskolin by HPLC
Lipolytic, cAMP stimulant
CENTEVITA™
HE
CENTELLA ASIATICA
SELECTED TRITERPENES
CHAMOMILE
K
COLEUS
DEVIL’S CLAW
H
Harpagophytum procumbens DC. - Root
≥1.8% ≤2.2% of harpagoside by HPLC
Joint health
IMMUNOSELECT®
ECHINACEA ANGUSTIFOLIA
K
Echinacea angustifolia DC. - Root
≥4.0% of echinacoside by HPLC
Immunomodulator, Antioxidant activity,
Soothing
Echinacea angustifolia DC. - Root
≥2.0% of echinacoside by HPLC, ≥5.0% of IDN 5405,
≤0.1% of isobutylamides
Immune system health
≥0.8% of caftaric, chicoric, chlorogenic acids and echinacoside by HPLC
Immune system health
≥0.5% of eleutheroside E by HPLC
Tonic
Aesculus hippocastanum L. - Seed
≥97.0% ≤103% by potentiometry
Healthy circulatory system
Ginkgo biloba L. - Leaf
≥24.0% of ginkgoflavonglucosides by HPLC, ≥6.0% as a sum of
ginkgolides A, B, C and bilobalide, ≥2.6% ≤3.2% of bilobalide by HPLC,
≤5 ppm of total ginkgolic acids by HPLC
Healthy circulatory system
POLINACEA®
ECHINACEA ANGUSTIFOLIA
ECHINACEA PURPUREA
K
Echinacea purpurea (L.) Moench - Root
ELEUTHEROCOCCUS
H
Eleutherococcus senticosus (Rupr. & Maxim)
Escin
GINKGOSELECT®
GINKGO BILOBA
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
H
Maxim - Root
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
12
13
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
GINKGO BILOBA EUR. PH.
Ginkgo biloba L. - Leaf
≥22% ≤27% of flavonoids by HPLC, ≥2.6 ≤3.2 of bilobalide by HPLC; ≥2.8
≤3.4 of ginkgolides A,B,C by HPLC, ≤5 ppm of ginkgolic acids by HPLC
Healthy circulatory system
GINKGO BILOBA
DIMERIC FLAVONOIDS
Ginkgo biloba L. - Leaf
≥24.0% ≤39.0% of total biflavones expressed as ginkgetin by HPLC
Antioxidant activity, Lipolytic
GINKGO BILOBA HF
H
Ginkgo biloba L. - Leaf
≥24% of ginkgoflavoglucosides by HPLC; ≥6% as sum of ginkgolides A,
B,C and bilobalide by HPLC; ≤5 ppm of total ginkgolic acids by HPLC
Cognitive and circulatory health,
Antioxidant activity
GINKGO BILOBA HF
TERPENES FREE
H
Ginkgo biloba L. - Leaf
≥24% of ginkgoflavonglucosides by HPLC; ≤0.1% of sum of ginkgolides
A, B, C and bilobalide
Cognitive and circulatory health,
Antioxidant activity
GINSENG 18-22%
Panax ginseng C.A. Meyer - Root
≥18.0% ≤22.0% of total ginsenosides and malonylginsenosides by HPLC
Adaptogen, Tonic
GINSENG 27-30%
Panax ginseng C.A. Meyer - Root
≥27.0% ≤30.0% of saponins by spectrophotometry,
≥20.0% of total ginsenosides by HPLC
Adaptogen, Tonic
GINSELECT® - GINSENG IDB
Panax ginseng C.A. Meyer - Root
≥7.0% of ginsenosides and malonylginsenosides;
≥0.9% ≤1.4% of Rg1; ≥1.7% ≤3.0% of Rb1 by HPLC
Adaptogen, Tonic, Elasticizing
H
Vitis vinifera L. - Leaf
≥12% of total polyphenols expressed as gallic acid by spectrophotometry
Antioxidant activity, circulatory health
LEUCOSELECT®
GRAPE SEED EXTRACT
KH
Vitis vinifera L. - Seed
≥95.0% ≤105.0% of proanthocyanidins by GPC,
≥13.0% ≤19.0% of catechin and epicatechin by HPLC
Antioxidant activity, circulatory health
ENOVITA®
GRAPE SEED EXTRACT
KH
Vitis vinifera L. - Seed
≥95.0% of proanthocyanidins by spectrophotometry,
≥5.0% ≤15.0% of catechin and epicatechin by HPLC
Antioxidant activity, circulatory health
H
Vitis vinifera L. - Seed
≥95.0% ≤105.0% of proanthocyanidins by GLC;
≥20.0% ≤30.0% of catechin and epicatechin by HPLC
Antioxidant activity, circulatory health
Camellia sinensis (L.) O. Kuntze - Young leaf
≥60.0% of total polyphenols, ≥40.0% of (-)-epigallocatechin-3-O-gallate,
≤0.1% of caffeine by HPLC
Antioxidant activity, Whitener
Camellia sinensis (L.) O. Kuntze - Young leaf
≥40% of total polyphenols by spectrophotometry, ≥15% of total catechin
expressed as epigallocatechin-3-O-gallate,
6% of epigallocatechin-3-O-gallate; 5.0% of caffeine by HPLC
Tonic, Antioxidant activity
RED LEAF GRAPE
GRAPE SEED MONOMERS
GREENSELECT® - GREEN TEA
GREEN TEA
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
H
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
14
15
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
GREEN TEA
H
Camellia sinensis (L.) O. Kuntze - Young leaf
≥75% of total polyphenols by spectrophotometry,
≥35% of total catechin expressed as epigallocatechin-3-O-gallate,
≥15% of epigallocatechin-3-O-gallate
Tonic, Antioxidant activity
GUARANA
K
Paullinia cupana H.B. et K. - Seed
≥11.0% ≤13.0% of total alkaloids by HPLC
Tonic, Stimulant
HAWTHORN
K
Crataegus spp. - Flowering top
≥1.8% of vitexin-2”-O-rhamnoside by spectrophotometry
Cardiovascular health, Antioxidant activity
HOPS
H
Humulus lupulus L. - Flowered head
≥0.3% of flavonoids by HPLC
Stress reliever
HORSE CHESTNUT
Aesculus hippocastanum L. - Seed
≥16.0% ≤22.0% of saponins expressed as escin
by spectrophotometry
Circulatory health
HORSE CHESTNUT BARK
DRY EXTRACT
Aesculus hippocastanum L. - Bark
≥20.0% of esculoside, esculetin, fraxetin and fraxin by HPLC
Circulatory health
Equisetum arvense L. - Herb
≥2.6% ≤3.2% of silica and ≥0.8% of total flavonoids expressed as
isoquercetin by spectrophotometry
Healthy Hair / Nail
IVY DRY HYDROALCOHOLIC EXT.
Hedera helix L. - Leaf
≥5.0% of hederacoside C by HPLC
Circulatory health
KOLA
Cola nitida (Vent.) Schott et Endl. - Seed
≥9.5% ≤13.0% of alkaloids by gravimetry
Expectorant
≥10% of hydroxycinnamic derivates calculated as rosmarinic acid
Stress reliever
≥0.5% of flavonoids by HPLC
Stress reliever
HORSETAIL
H
LEMON BALM
K
Melissa officinalis L. - Flowered head
LINDEN TREE
H
Tilia cordata Mill. /Tilia platyphyllos Scop. -
LYMPHASELECT® - MELILOTUS
H
Melilotus officinalis (L.) Pallas - Herb
≥17.0% ≤20.0% of coumarin by HPLC
Lymphatic system health
Panicum miliaceum L. - Seed
≥3.0% of fatty acids by GC
Healthy skin,
Skin barrier function improver
Panicum miliaceum L. - Seed
≥7.0% ≤10.0% of fatty acids by GC; ≥40.0% ≤60.0% of methionine by HPLC
Healthy skin
MILLET
MILLET
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
H
Flower
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
16
17
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
(continue)
BRAND - English name
OLEASELECT® - OLIVE
HK
OPEXTAN® - OLIVE
Botanical origin
Assay
Biological Activity
Olea europaea L. - Fruit
≥30% of total polyphenols by spectrophotometry;
≥1.5% of hydroxytyrosol, ≥5.0% of verbascoside by HPLC
Antioxidant activity,
Healthy cardiovascular function
≥10.0% of total polyphenols by spectrophotometry; ≥2.0% ≤3.5% of
verbascoside, ≥4.5% of hydroxytyrosol and its derivatives by HPLC
Antioxidant activity, Healthy skin,
Healthy cardiovascular function
GHKE Olea europaea L. - Fruit
PASSION FLOWER
K
Passiflora incarnata L. - Aerial part
≥4.0% of flavonoids as vitexin by spectrophotometry
Stress reliever
PASSION FLOWER
H
Passiflora incarnata L. - Aerial part
≥2.0% ≤2.6% of total flavonoids by spectrophotometry
Stress reliever
Krameria lappacea (Dombey) Burdet - Root
≥13.5% ≤16.5% of neolignans, expressed as eupomatenoide-6 by HPLC
Antioxidant activity
Rheum emodi Wall. - Rhizome
≥9% ≤11% of total anthraquinones calculated as aloe-emodin
Eupeptic, Healthy digestion
RUSCOGENINS C
Ruscus aculeatus L. - Rhizome and root
≥92.0% ≤103.0% of ruscogenins, ≥60.0% ≤80% of
neoruscogenin, ≥20% ≤40% of ruscogenin by HPLC
Anticellulite, Circulatory health
SENNOSIDES 45%
Cassia angustifolia Vahl. - Leaf
≥42.5% ≤47.5% of hydroxyanthracene glycosides, calculated as
sennoside B by spectrophotometry
Laxative
SENNOSIDES 60%
Cassia angustifolia Vahl. - Leaf
≥55.0% ≤65.0% of sennosides by spectrophotometry
Laxative
Silybum marianum (L.) Gaertn. - Fruit
≥50.0% ≤60.0% of silymarin calculated as silybin by HPLC according
to Ph. Eur. (corresponding to NTL 65% according to DAB 10 ≥30.0% by
spectrophotometry)
Healthy liver, Antioxidant activity
MADEGLUCYL®
EUGENIA JAMBOLANA
Syzygium cumini (L.) Skeels - Seed
2% of ellagic acid by HPLC; hypoglycemic effect ≥20.0%
Healthy blood sugar metabolism
SOYSELECT® - SOYBEAN
Glycine max (L.) Merr. - Seed
≥18% of B-type saponins,
≥13.0% ≤17.0% of isoflavone glycosides by HPLC
Menopause-related symptoms controller
ST. JOHN’S WORT
Hypericum perforatum L. - Flowering top
≥0.10% ≤0.30% of total hypericin, ≥6.0% of flavonoids,
≤6.0% of hyperforin by HPLC
Healthy mood
RATHANY
RHUBARB
K
SILYMARIN
K
PHARMACEUTICAL
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
HEALTH - FOOD
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
PERSONAL CARE
Indena’s Personal Care ingredients are REACH registered.
18
HALAL
certified
E
G
ECOCERT
validated
KOSHER
certified
C
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
CEP
granted
GRAS: the product can be used
as an ingredient in common food
19
STANDARDIZED, PURIFIED or OTHER
CHARACTERIZED DRY EXTRACTS
DRY EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
ST. JOHNSELECT®
ST. JOHN’S WORT
Hypericum perforatum L. - Flowering top
≥0.3% of hypericin like substances by spectrophotometry,
≥3.0% of hyperforin by HPLC
Healty mood
ST. JOHN’S WORT
H
Hypericum perforatum L. - Flowering top
≥0.27% ≤0.33% of total hypericin
Healty mood
TURMERIC DRY EXTRACT
K
Curcuma longa L. - Rhizome
≥4.0% of curcumin like derivatives as curcumin by spectrophotometry
Joint health
XILOGEL® - TAMARIND SEED
POLYSACCHARIDE
Tamarindus indica L. - Seed
≥85% of xyloglucane by HPLC
Moisturizer, Skin restructurant,
Antiwrinkles
XIMENOIL® - XIMENYNIC ACID
Santalum album L. - Seed
≥ 98.0% ≤105% by potentiometry
Circulatory health, Skin nourishing
Valeriana officinalis L. - Rhizome and root
≥0.8% of valerenic acids by HPLC
Sedative
Salix spp. - Twig and bark
≥15.0% of salicin by HPLC
Joint health
VALEROSELECT® - VALERIAN
KC
WILLOW BARK
H
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
20
21
CHARACTERIZED, STANDARDIZED
OILY and SOFT EXTRACTS
OILY / SOFT EXTRACTS WITH REPRODUCIBLE CONTENT
OF CHARACTERISTIC PRINCIPLES
BRAND - English name
Botanical origin
Assay
Biological Activity
CURBILENE® - PUMPKIN SEEDS
K
Cucurbita pepo L. - Naked seed
≥85.0% of fatty acids by GC
Healthy prostate and bladder function,
Skin matting
OMEGABLUE® - BILBERRY SEED
E
Vaccinium myrtillus L. - Seeds
≥80.0% total fatty acids by GC; ≥50% total polyunsaturated fatty acids by GLC
Cholesterol health, Skin restructurant,
Healthy digestion
PRUNUSELECT®
PYGEUM AFRICANUM
H
Prunus africana (Hook. F.) Kalkm. - Bark
≥11.7% ≤14.3% of total sterols by spectrophotometry
Healthy prostate and bladder function
Rheum palmatum L. - Rhizome
≥1.0% of anthraquinones as aloe-emodin by spectrophotometry
Laxative
CHINESE RHUBARB SOFT
AQUEUS EXTRACT
SABALSELECT®
SAW PALMETTO
K
Serenoa repens (Bartr.) Small - Fruit
≥85.0% ≤95.0% of fatty acids, ≥0.01% ≤0.15% of fatty alcohols,
≥0.25% ≤0.50% of total sterols, ≥0.15% ≤0.35% of β-sitosterol by GC
Healthy prostate and bladder function,
Anti 5-α reductase
SAW PALMETTO
ALCOHOLIC EXTRACT
K
Serenoa repens (Bartr.) Small - Fruit
≥85.0% ≤95.0% of fatty acids, ≥0.01% ≤0.15% of fatty alcohols,
≥0.25% ≤0.50% of total sterols, ≥0.15% ≤0.35% of β-sitosterol by GC
Healthy prostate and bladder function
Santalum album L. - Seed
≥70.0% of ethylximenynate by HPLC
Circulatory health
Zanthoxylum bungeanum Maxim. - Pericarp
≥4.4% ≤6.4% of alkylamides by HPLC
Soothing, Skin sensitivity
modulator, Lifting agent
XIMILENE® - ETHYLXIMENYNATE
ZANTHALENE® - ZANTHOXYLUM
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
E
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
22
23
PHYTOSOME
MORE BIOAVAILABLE ACTIVE INGREDIENTS
BRAND - English name
Botanical origin
Assay
Biological Activity
BOSEXIL™
FRANKINCENSE PHYTOSOME
Boswellia serrata Roxb. ex Colebr. - Resin
≥25% boswellic acids by HPLC
Soothing, Healthy digestion
CASPEROME™ - BOSWELLIA
PHYTOSOME
Boswellia serrata Roxb. ex Colebr. - Resin
≥25% boswellic acids by HPLC
Joint health,
Soothing, Healthy digestion
CENTELLA ASIATICA
SELECTED TRITERPENES
PHYTOSOME
Centella asiatica (L.) Urban - Leaf
≥30.0% ≤35.0% of selected triterpenes by HPLC
Collagen restructurant, Antiwrinkles agent
ESCIN β-SITOSTEROL
PHYTOSOME
Aesculus hippocastanum L. - Seed
≥32.0% ≤40.0% of escin by TLC, ≥12.5% ≤15.5% of β-sitosterol by TLC
Healthy skin, Healthy tissue
≥7.0% of ginkgoflavonglucosides, ≥2.0% of ginkgoterpenes,
≥ 0.8% of bilobalide, ≥0.8% of ginkgolides by HPLC
≤5 ppm of total ginkgolic acids by HPLC
Cognitive and circulatory system health,
Antioxidant activity
GINKGOSELECT® PHYTOSOME
GINKGO BILOBA PHYTOSOME
K
Ginkgo biloba L. - Leaf
VIRTIVA® - GINKGO BILOBA
PHOSPHATIDYLSERINE
PHYTOSOME
H
Ginkgo biloba L. - Leaf
≥5.0% of ginkgoflavonglucosides, ≥0.5% of ginkgoterpenes,
≥12.0% of phosphatidylserine by HPLC
Cognitive system health
GINKGO BILOBA
DIMERIC FLAVONOIDS
PHYTOSOME
Ginkgo biloba L. - Leaf
≥10.0% of total biflavones expressed as ginkgetin by HPLC
Lipolytic, Circulatory health,
Phosphodiesterase inhibitor
GINKGO BILOBA TERPENES
PHYTOSOME
Ginkgo biloba L. - Leaf
≥30.0% of total ginkgoterpenes, ≥10.0% of bilobalide,
≥10.0% of ginkgolides A, B, C, J by HPLC
Soothing, Healthy digestion, Healthy
immune system
Panax ginseng C.A. Meyer - Root
≥30.0% ≤40.0% of ginseng typical constituents by gravimetry
Adaptogen, Tonic, Skin health
GINSELECT® PHYTOSOME
GINSENG IDB PHYTOSOME
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
K
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
24
25
PHYTOSOME
MORE BIOAVAILABLE ACTIVE INGREDIENTS
(continue)
BRAND - English name
Botanical origin
Assay
Biological Activity
18β-glycyrrhetinic acid
PHYTOSOME
Glycyrrhiza glabra L.- Root
≥27.0% ≤31.0% of 18β-glycyrrhetinic acid by HPLC
Soothing, Lenitive
GREENSELECT® PHYTOSOME
GREEN TEA PHYTOSOME
Camellia sinensis (L.) O. Kuntze - Young leaf
≥19.0% ≤25.0% of polyphenols expressed as (-)-epigallocatechin-3-Ogallate, ≥ 13.0% of (-)-epigallocatechin-3-O-gallate,
≤0.1% of caffeine by HPLC
Antioxidant activity, Weight loss agent
HAWTHORN PHYTOSOME
Crataegus spp. - Flowering top
≥3.0% of vitexin-2’’-O-rhamnoside by HPLC
≥28% ≤34% of Hawthorn typical constituents
Cardiovascular health, Antioxidant activity
LEUCOSELECT® PHYTOSOME
GRAPE SEED PHYTOSOME
Vitis vinifera L. - Seed
≥25% ≤30% of proanthocyanidins by GPC
Healthy cardiovascular function,
UV protectant, Antioxidant activity
PROANTHOCYANIDIN A2
PHYTOSOME
Aesculus hippocastanum L. - Bark
≥31.0% ≤37.0% of proanthocyanidin A2 by HPLC
UV protectant, Cicatrizing-trophodermic,
Firming and oval reshaping agent
REXATROL®
RESVERATROL PHYTOSOME
Polygonum cuspidatum Sieb. e Zucc. - Rhizome
≥30% of resveratrol by HPLC
Antioxidant activity, Antiageing, Sirt 1
modulator
SERICOSIDE PHYTOSOME
Terminalia sericea Burch. ex. DC. - Root bark
≥25.0% of sericoside by HPLC
Antioxidant activity, Healthy skin,
Antiwrinkles, Soothing, Redensifier
SILYMARIN PHYTOSOME
K
Silybum marianum (L.) Gaertn. - Fruit
≥15.0% ≤20.0% of flavolignans calculated as silybin by HPLC
Healthy liver function, Antioxidant activity,
Healthy skin
SILIPHOS®
SILYBIN PHYTOSOME
K
Silybum marianum (L.) Gaertn. - Fruit
≥29.7% ≤36.3% of silybin by HPLC
Healthy liver function
MERIVA®
TURMERIC PHYTOSOME
H
Curcuma longa L. - Rhizome
≥18.0% ≤22.0% of curcuminoids by HPLC
Joint health
Ammi visnaga (L.) Lam. - Umbel without fruits
≥10.0% ≤13.0% of visnadin by TLC
Vasokinetic
VISNADEX®
VISNADIN PHYTOSOME
PHARMACEUTICAL
HEALTH - FOOD
PERSONAL CARE
Indena’s Active Pharmaceutical Ingredients are produced in
compliance with cGMPs and in pharmaceutical inspected
suites, supported by CTD-DMFs.
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
Indena’s Personal Care ingredients are REACH registered.
26
27
BOTANICAL EXTRACTS with
ORGANOLEPTIC PROPERTIES
BRAND - English name
TOLU’ BALSAM EXTRACT
K
QUASSELECT® - Quassia
HK
Botanical origin
Assay
Biological Activity
Myroxylon balsamum (L.) Harms var. balsamum
≥32% ≤38% of sucrose by oxidimetry
Sweet
Picrasma excelsa (Sw.) Planch.
(Quassia amara L.) - Wood
≥53.0% ≤57.0% as a sum of quassin and neoquassin by HPLC
Bitter
VANILLA
K
Vanilla planifolia (B. D. Jackson) - Capsule
≥5.0% of vanillin by HPLC
Sweet
GINGER
K
Zingiber officinale Roscoe - Rhizome
≥0.8% essential oils
Pungent
CINCHONA
K
Cinchona spp. - Bark
≥19% ≤21% of total alkaloids
Bitter
AMMONIUM GLYCYRRHIZATE
K
Glycyrrhiza glabra L.- Root
≥98% ≤102% of monoammonium glycyrrhizate
Sweet
GLYCAMIL COMPOUND N
K
Glycyrrhiza glabra L.- Root
≥9.5% ≤10.5% of triterpenic glucosides
as monoammonium glycyrrhizate
Sweet
LICORICE
K
Glycyrrhiza glabra L.- Root
≥5.0% ≤6.2% of glycyrrhizic acid by HPLC
Sweet
HEALTH - FOOD
Indena’s ingredients for food supplements are produced
under Hazard Analysis and Crytical Control Points (HACCP).
28
HALAL
certified
E
ECOCERT
validated
PACKAGING MATERIALS :: Food
grade polyethylene bags, multilayer
bags :: Kraft type cardboard drums,
metallic drums, polyethylene drums,
polypropylene pails (UN approved
drums are used for hazardous products)
KOSHER
certified
C
CEP
granted
29
printed by Papergraf S.p.A.
Cod. DPR 0209 - 07/2012*02/2013
.
INDENA S.A.S
INDENA USA Inc.
Two Union Square
601 Union Street, Suite 330
Seattle, WA 98101 - USA
tel. +1.206.340.6140
us.indena.com