2009-2010 University of Chicago Cancer Research Center Annual
Transcription
2009-2010 University of Chicago Cancer Research Center Annual
O2C H Groundbreaking Research, H H Customized Patient HO O O OAc H Care O OH O HO O O O H OH H CO2CH3 2 0 0 9 – 2 0 1 0 A n n u a l R e p o r t At the Forefront of Discovery TM 225 UCCCC members are scientists, researchers, physicians, and caregivers. The UCCCC added eight new members in fiscal year 2009–2010. They are: Bulent Aydogan, PhD Assistant Professor of Radiation and Cellular Oncology Program 5: Advanced Imaging M. Kelly Nicholas, MD, PhD Assistant Professor of Neurology Program 4: Clinical and Experimental Therapeutics Peter Savage, PhD Assistant Professor of Pathology Program 3: Immunology and Cancer Lucia Schuger, MD Professor of Pathology Program 1: Cell Signaling and Gene Regulation The University of Chicago Comprehensive Cancer Center (UCCCC) is committed to exploring and developing innovative ways to prevent and reduce cancer’s devastating effects. The UCCCC is one of only 40 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only two in Illinois. The designation means more than just state-of-the-art care and services. It also means a strong, high-quality research base combined with a wide spectrum of prevention, education, information, and dissemination activities that broadly serve our surrounding communities, as well as the Midwest region and the nation. The UCCCC has earned a reputation for excellence, innovation, and a commitment to addressing cancer from every angle. Stephen Skapek, MD Associate Professor of Pediatrics Program 1: Cell Signaling and Gene Regulation Russell Szmulewitz, MD Instructor of Medicine Program 4: Clinical and Experimental Therapeutics Donald Vander Griend, PhD Assistant Professor of Surgery Program 1: Cell Signaling and Gene Regulation Samuel Volchenboum, MD, PhD, MS Assistant Professor of Pediatrics Program 1: Cell Signaling and Gene Regulation 1 A Message from the Director 2 New Name Recognizes Depth and Breadth of the UCCCC 4 Highly Competitive Grants Advance UChicago Cancer Research 6 Research Discoveries Translate into Comprehensive Cancer Care 8 Personalized Medicine Moves Within Reach 10 State-of-the-Art Facilities Improve Patient, Research Experience 12 Advanced Technologies Speed Discovery 14 Outreach Programs Help Strengthen Ties with Community 16 Report from the Cancer Registry 19 A Focus on Head and Neck Cancer 22 Team Approach Creates Top-Notch Head and Neck Cancer Treatment Outcomes 24 Foundation Makes Significant Contribution to Cancer Research 40 Pursuing Groundbreaking Research to Deliver Customized Cancer Care A Message from the Director This has been an exciting year for the UCCCC. Our members have once again demonstrated excellence in every aspect of cancer research, prevention, diagnosis, treatment, and survivorship—proving that we are a comprehensive cancer center of distinction. We hope you will find this fiscal year 2009-2010 overview to be interesting and informative. Our groundbreaking research has truly led to customized care for our patients. The nation’s biomedical community has applauded our members’ outstanding contributions in many tangible ways. They selected members for major awards, elected them to national academies, and voted them into leadership posts in national associations. We have listed a small sample of these accolades in the sidebar on page 13. The University of Chicago Cancer Research Foundation (UCCRF) and other generous contributors were essential to our successes, providing valuable funding for resources and facilities and volunteering time to help advance the UCCCC mission to explore and develop innovative ways to prevent and reduce cancer’s devastating effects. A list of donors begins on page 28. Our contributors supported the preliminary research required to obtain major funding from the government and other institutions. They also support faculty recruitment, equipment technologies, and pilot projects. We can directly link many of our most transformative discoveries to research initiated with philanthropic support. In this report, we highlight the accomplishments and members of The University of Chicago Head and Neck Cancer Program, whose pioneering concepts are now considered the standard of care. The special section begins on page 19. As members, staff, and supporters, we can all be proud of the UCCCC’s achievements and look forward to a future of exciting advances in cancer research and care. It is a great privilege to have this opportunity to thank all of you for your diligence, insight, creativity, and compassion for cancer patients and their families around the world. With heartfelt gratitude, Michelle M. Le Beau, PhD Professor of Medicine Director, The University of Chicago Comprehensive Cancer Center UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 1 S. Diane Yamada, MD 15 # Top-Ranked Cancer Program The University of Chicago Medical Center is consistently ranked as a top hospital in U.S. News & World Report’s annual survey. In 2010, the cancer program at UChicago was the highest ranked cancer program in Illinois and ranked #15 out of nearly 5,000 hospitals evaluated nationwide. 6 How a Comprehensive Cancer Center Works rch ea LABic Res s Ba CLI N Pat IC i and ent C Clin are ica l Tr ial Training and Translational Research ON l ATI UL CES ontroch P PO CIEN cer C trea S an Ou C nd a DISCOVERY s DELIVERY Mechanism-based multidisciplinary science TRANSLATIONAL Interdisciplinary Cancer Research Programs • • • • • • Cell Signaling and Gene Regulation Hematopoiesis and Hematological Malignancies Immunology and Cancer Clinical and Experimental Therapeutics Advanced Imaging Cancer Risk and Prevention New Name Recognizes Depth and Breadth of the UCCCC The new year represents a significant event for many people. It signifies a new start and an opportunity for new commitments. For The University of Chicago Cancer Research Center, the new year marks the date we officially changed our name to The University of Chicago Comprehensive Cancer Center (UCCCC). The modification was much more than the substitution of a single word. The new name acknowledges the National Cancer Institute’s (NCI’s) continued recognition of the depth and breadth of the UCCCC’s programs and underscores the center’s capacity and commitment to pursue the abundance of new opportunities in cancer prevention, detection, treatment, and survivorship. The name change also fits our times—a period in which breakthroughs in genetics, technology, and molecular biology help power a revolution in comprehensive cancer care. This annual report focuses on how the UCCCC is capitalizing on its groundbreaking research and leveraging these advances to create customized care for all cancer patients. In the past year, UCCCC members introduced innovative combinations of chemotherapy, radiotherapy, and surgical therapies to enhance patient outcomes, used advanced computational techniques to analyze the genetic compositions of individual tumors, and identified molecular targets to make drug therapies more precise and effective. Our researchers investigated innovative ways to halt the spread of cancer to other parts of the body, to help the human immune system seek and destroy cancer cells, and to enable cancer survivors to live longer and preserve quality of life. Our members also expanded our understanding of how cancer stem cells multiply and mature and the roles of specific proteins in regulating cell death and proliferation. They developed community partnerships that promoted healthy living and cancer prevention, and they determined how environmental, lifestyle, and social factors can make patients more susceptible to particular cancers. They analyzed treatment regimens to maximize effectiveness and reduce harmful physical and psychological impacts. Our members also continued to explore the use of molecular-scale microdiscs to destroy tumors, the recruitment of antibodies and modified viruses to carry anticancer agents directly to individual tumor cells, and the capacity of advanced imaging to detect pre-cancerous lesions less than several hundred microns in diameter. The prospects of the fast-paced evolution of our understanding of the biological mechanisms underlying cancer and more effective approaches for tackling all aspects of the disease are invigorating. UCCCC members lead the vanguard of the transformation in cancer research. They are At the Forefront of Discovery™, bringing new hope to our nation in which one-out-of-two men and one-out-of-three women will be diagnosed with cancer during his or her lifetime. UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 3 Highly Competitive Grants Advance UChicago Cancer Research Investment in cancer research is vital for a future without malignant disease. 4 4 Philip Connell, MD CCTO Expands The UCCCC’s Cancer Clinical Trials Office (CCTO) provides oversight, quality control, protocol tracking, and management for cancer clinical trials at UChicago. Beginning in fiscal year 20102011, CCTO will manage cancer trials from four new units— the Departments of Surgery, Radiation and Cellular Oncology, and Radiology, and the Section of Gynecologic Oncology, in addition to the Department of Medicine. UCCCC members received 71 ARRA grants in FY 2009–2010 and were involved in 700 new and ongoing research projects. Daniel Haraf, MD, MS M. Eileen Dolan, PhD This past fiscal year, the Federal government gave UChicago researchers a huge vote of confidence by awarding them 196 grants through the American Recovery and Reinvestment Act (ARRA). The nearly $97 million in ARRA funding provided to UChicago will not only accelerate the pace of scientific discovery, but will also enable the University to retain and recruit staff to support research projects. Federal agencies, such as the National Institutes of Health (NIH), were particularly generous to UCCCC members in awarding ARRA funding. Forty-four of our members received 71 grants totaling $28.5 million. The projects funded through ARRA grants range from developing a fast, inexpensive way to create mouse models to study human genetic diseases, to developing drugs to help the immune system fight cancer, to determining the diagnostic accuracy of handheld oral cancer screening devices, to training African American and Hispanic undergraduates to research and eliminate health disparities in underserved populations. In addition to ARRA grants, UCCCC members were also involved in more than 700 new and ongoing research projects. These projects are supported through grants from NIH and its institutes, including the National Cancer Institute, as well as the American Cancer Society, The University of Chicago Cancer Research Foundation, and the Cancer Research Foundation. Among the newly funded grant projects in fiscal year 2009–2010 were: Rational Generation of Directed Protein-Capture Reagents Shohei Koide, PhD, professor of biochemistry and molecular biology, and his team are establishing a faster, easier approach for generating high-performance research reagents, which help discriminate UCCCC 2009–2010 Annual Report n cancer.uchicago.edu normal cells from diseased cells and tissues. The project is built on an innovative proteinengineering concept, termed Affinity Clamping, that Dr. Koide’s group recently established. “This innovative and powerful technology will fill a major void in the currently available molecular tools and will have a major impact on virtually all areas of molecular biomedical sciences, diagnosis, and drug development,” said Dr. Koide. Replication Study of Breast Cancer Susceptibility Genes in Blacks Dezheng Huo, MD, PhD, assistant professor of health studies, and colleagues are translating recent advances in genetics to benefit women who are at risk of developing an aggressive form of breast cancer at a young age. “The study will accurately define genetic risks for women in the African Diaspora, which will lead to better clinical risk assessment and the development of more effective strategies for prevention, early detection, and treatment of breast cancer for all women,” said Dr. Huo. “Aberrant control of hematopoiesis is the underlying cause of many diseases including immune deficiency, anemia, autoimmunity, and leukemia or lymphoma,” Dr. Kee explained. Transcriptional Control of Hematopoiesis Barbara Kee, PhD, associate professor of pathology, and her research team are determining the molecular mechanisms that control hematopoiesis—the formation of blood cells in the body— with a particular emphasis on the white blood cell system. “Aberrant control of hematopoiesis is the underlying cause of many diseases including immune deficiency, anemia, autoimmunity, and leukemia or lymphoma,” Dr. Kee explained. Genetic Determinants Associated with Pemetrexed Response and Toxicity M. Eileen Dolan, PhD, professor of medicine, and her colleagues are identifying lung cancer patients at risk for toxicities or lack of response following treatment with the chemotherapeutic agent pemetrexed. “Ultimately, we hope to find predictive markers of pemetrexed response and toxicity,” Dr. Dolan said. Daniel Appelbaum, MD Yingming Zhao, PhD 5 Research Discoveries Translate into Comprehensive Cancer Care The UCCCC is committed to improving the lives of our cancer patients and their families. Stacy Lindau, MD Stacey Sandbo, NP The UCCCC places a high priority on the long-term care of cancer survivors who often face physical and psychological difficulties following their treatment. Translating scientific breakthroughs into targeted therapies and state-of-the-art procedures represents a coordinated endeavor among UCCCC clinicians and scientists who are deciphering the biological processes that control cancer development. Our researchers are transforming their knowledge of genetic alterations and cell signaling pathways into medical advances that improve cancer prevention, diagnosis, treatment, and survivorship. Cancer is influenced by our genes, environment, and lifestyle. While choosing the right health and 6 dietary behaviors can help reduce cancer risk, UCCCC researchers are working diligently to develop advanced screening procedures to detect precancerous lesions before they even become cancer. Gregory Karczmar, PhD, professor of radiology, has developed a groundbreaking technique using magnetic resonance imaging and spectroscopy (MRIS) to detect ductal carcinoma in situ (DCIS) in mouse mammary glands. Early detection of DCIS, a precursor to invasive breast cancer, will allow clinicians to prevent cancer progression by identifying and treating suspect lesions. UCCCC experts, including Olufunmilayo Olopade, MBBS, FACP, the Walter L. Palmer Professor of Medicine and Human Genetics, associate dean for global health, and director of the Cancer Risk Clinic, are also developing genetic tests to assess an individual’s risk for hereditary cancers, including breast, colon, ovarian, and pancreatic cancers. Once identified, high-risk patients can be monitored closely and screened periodically for early detection of cancers when they are most curable. Early cancer detection requires advanced imaging technologies that are extremely precise and accurate. The UCCCC is developing new imaging techniques and procedures that enable scientists to see deeper into cells and understand the complex biological processes underlying cancer. These advances are improving cancer diagnosis. For example, Xiaochuan Pan, PhD, professor of radiology, is developing new diagnostic imaging approaches for computed tomography (CT), a widely used technology that computes multidimensional images from X-ray images taken around the patient. His research will enable the production of higher quality images from less CT data, which increases diagnostic accuracy while subjecting patients to less radiation. These novel advances in CT and other imaging tools allow UCCCC clinicians to detect cancers earlier and monitor treatment responses more closely. Through basic laboratory discoveries, the UCCCC is designing and delivering the most targeted 358 and customized treatment options for patients. Researchers in the Department of Radiation and Cellular Oncology, including Chairman Ralph Weichselbaum, MD, are identifying the genetic profile of tumors resistant to radiation therapy. With this information, clinicians will soon be able to determine which patients may or may not respond to therapy and devise individualized treatment plans. Similarly, UCCCC researchers are working on the Chicago Cancer Genome Project to develop comprehensive genetic data from 1,000 tumors. By correlating this information with patient outcomes, researchers will be able to predict how cancers behave and translate these discoveries into diagnostic tools and personalized therapies. The Childhood Cancer Survivors Center follows patients after treatment and screens for future risks to minimize the impact of childhood cancer therapies. The UCCCC also places a high priority on the long-term care of cancer survivors who often face physical and psychological difficulties because of the toxicities of their treatment. The Childhood Cancer Survivors Center follows patients after treatment and screens for future risks to minimize the impact of childhood cancer therapies. The Breast Cancer Survivorship Program helps women deal with the long-term impacts of breast cancer. UCCCC members, through the Program in Integrated Sexual Medicine (PRISM) for Women and Girls with Cancer, combine research, prevention, and treatment with outreach and education for female patients who may be encountering sexual problems. Through these and other efforts, the UCCCC is increasing the quality of life for cancer survivors. Open Cancer Clinical Trials at UChicago Cancer clinical trials test the safety and effectiveness of new treatments for cancer in select patients before the treatments can be made widely available. UChicago performs more clinical trials than any other facility in Illinois. (as of 8/18/10) John Cunningham, MD UCCCC 2009–2010 Annual Report n cancer.uchicago.edu Top 5 Studies Lung/Chest Breast Leukemia (adult) Prostate Cancer Head/Neck 45 43 29 25 16 Pediatric Trials Pediatric Solid Tumors Pediatric Other Pediatric Brain Pediatric Leukemia Pediatric Lymphoma 9 9 5 4 2 Olufunmilayo Olopade, MBBS, FACP 7 Personalized Medicine Moves Within Reach Much of today’s medicine is reactive, where diagnosis and treatment are administered only after patients become ill. The UCCCC is pursuing innovative research that is transforming our understanding of cancer and is paving the way for a new era of predictive, personalized medicine. Personalized medicine, which considers an individual’s genetic makeup and the genetic and biological characteristics of their tumor, will enable physicians to identify people who are at greater risk for cancer, determine how patients may respond to various treatments, and guide the development of customized therapies for both cancer prevention and treatment. Certain genetic variants and abnormalities are known to increase cancer susceptibility. Our researchers are using advanced tools and techniques to identify these genetic changes. The UCCCC’s world-renowned leukemia team is using a systems biology approach to unravel the genetic complexities of therapy-related acute myeloid leukemia (t-AML), a particularly cruel and fatal disease caused by cancer treatment itself. Systems biology is an emerging field that focuses on how multiple genes or proteins work together in networks to regulate biological systems as a whole, such as blood development. Led by Michelle M. Le Beau, PhD, professor of medicine and director of the UCCCC, the fight against t-AML represents a multidisciplinary effort that engages the expertise of clinical oncologists, geneticists, biologists, and computer scientists. Their discoveries will allow 8 clinicians to develop personalized therapies and genetic tests to identify patients at risk for t-AML. UCCCC researchers also perform genome-wide association (GWA) studies to determine cancer risk and predict response to therapy. These studies involve the analysis of genetic variations across the entire human genome to identify alterations that are associated with disease or specific conditions. By identifying factors associated with poor prognosis, researchers will be able to develop more effective therapies that specifically target these genetic alterations. Similarly, our members excel in the development of personalized medicine by conducting GWA studies to identify genetic variations associated with drug response and adverse therapeutic side effects. Patients may display a wide range in drug responses and side effects because, for example, they may have genetic alterations that affect the expression of enzymes that eliminate specific drugs from their systems. In one study, genetic differences between people of European and African ancestry were attributed to population differences in drug response. These pharmacogenetic studies will allow clinicians to predict how patients respond to chemotherapeutic drugs and ultimately develop personalized treatment plans that maximize drug response and minimize side effects. Edwin Posadas, MD (right) At the UCCCC, our researchers are revolutionizing personalized cancer care by developing genetic tests that determine cancer risk, creating new targeted cancer drugs that are being tested in clinical trials, and identifying new genetic markers that predict which patients will most likely to benefit from these drugs. Alessandro Fichera, MD A large, world-class cancer research program, such as ours, elevates the quality of patient care by providing a level of expertise unavailable at most other medical centers. UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 9 State-of-the-Art Facilities Improve Patient, Research Experience The physical landscape changed dramatically on the UChicago campus over the past fiscal year. 12 Core Facilities The UCCCC supports core facilities, as research and educational resources, through its NCI Cancer Center Support Grant. • Biostatistics Core Facility • Cancer Clinical Trials Office • Frank W. Fitch Monoclonal Antibody Facility • Flow Cytometry Facility • Genomics Core Facility • Human Immunologic Monitoring Core Facility • Human Tissue Resource Center • Integrated Microscopy Facility • Magnetic Resonance Imaging and Spectroscopy Facility • Pharmacology Core Facility • Scientific Image Reconstruction and Analysis Facility • Transgenic Mouse and Embryonic Stem Cell Facility The complex study of cellular, genetic, and molecular mechanisms that contribute to cancer requires sophisticated technologies available in our new facilities. 10 In addition to new signage recognizing the new name of the UCCCC, construction is well under way on the futuristic New Hospital Pavilion. The 10-story, 1.2 million-square-foot facility, scheduled for completion in early 2013, has an innovative and efficient design that will help enhance collaboration and interaction among clinicians while providing a haven for patients and families dealing with complex illnesses, including cancer. Designed by renowned architect Rafael Viñoly, the seventh floor will feature a Sky Lobby—an elevated public space that includes central reception, family waiting areas, a chapel, gift shop, dining areas, and other public spaces. Its floor-to-ceiling glass walls will provide expansive views of the UChicago campus, as well as Lake Michigan, Washington Park, and the downtown Chicago skyline. The New Hospital Pavilion spans two city blocks on 57th Street and will connect to Comer Children’s Hospital and the outpatient Duchossois Center for Advanced Medicine (DCAM). A new 24/7 cancer unit opened in July 2009 making it more convenient for patients requiring care. Instead of waiting in the emergency room or in the Infusion Therapy Suite, cancer patients can visit the Oncology Evaluation Unit in Bernard A. Mitchell Hospital to receive treatments, including fluid and electrolyte replacements, lab draws, injections, blood transfusions, and antibiotics. The unit has 12-beds and delivers a hybrid of inpatient and outpatient care. More than 1,000 patient visits were recorded in the Oncology Evaluation Unit in its first year. Also celebrating its first year in operation was the The Gwen and Jules Knapp Center for Biomedical Discovery (KCBD), which opened in June 2009. UCCCC 2009–2010 Annual Report n cancer.uchicago.edu The 10-story glass-walled facility provides research space to about 50 UCCCC researchers. It has dedicated core space for the Genomics, Transgenic Mouse/ES Cell, and Integrated Microscopy Facilities. KCBD houses the Flow Cytometry Satellite Facility, Ludwig Center for Metastasis Research, and Institute for Genomics and Systems Biology. It is also the setting for the hematology and oncology research programs for the Departments of Medicine and Pediatrics. These facilities serve as the backdrop to the superior, groundbreaking research by our internationally recognized teams of investigators. “Efficient implementation of team-based research studies requires contiguous space to house multidisciplinary faculty and staff, as well as integrated dry and wet laboratory space with flexible configurations,” said Habibul Ahsan, MD, MMedSc, associate director for population research for the UCCCC and professor of health studies, medicine, and human genetics. “The well-planned and state-of-the-art environment that KCBD provides to these facilities has already begun to promote interdisciplinary population research on molecular and genetic epidemiology, thus aiding our effort to discover novel genes and gene-environment interactions in cancer risk, prevention, and survival.” The New Hospital Pavilion spans two city blocks on 57th Street and will connect to Comer Children’s Hospital and the outpatient Duchossois Center for Advanced Medicine (DCAM). Over the past year, Dr. Ahsan and UChicago research teams have completed a large, genomewide association study of breast cancer, analyzing DNA samples from 7,000 women from the U.S., Canada, Germany, and Australia. “We used stateof-the-art molecular genomic technologies as well as sophisticated computing and statistical tools to decipher millions of common genomic variations in each of the DNA samples,” he said. As a result, the team has identified novel genomic imprints associated with early onset breast cancer. They are now relying on their new, adjacent wet and dry laboratory spaces to confirm the findings. 11 Advanced Technologies Speed Discovery The evolution of sophisticated technologies is accelerating the pace of discovery and cancer care at UChicago. Richard Jones, PhD, assistant professor in the Ben May Department for Cancer Research, and his colleagues have developed the micro-western array, a new, proprietary technology that enables researchers to examine hundreds of proteins simultaneously and obtain a comprehensive view of their intricate networks. This technology may help explain why some tumors develop resistance to current therapies and could open the door to a much greater understanding of other diseases. UChicago’s Institute for Genomics and Systems Biology (IGSB), under the direction of Kevin White, PhD, the James and Karen Frank Family Professor of Human Genetics and professor of ecology and evolution, is pushing its research boundaries. IGSB researchers are using the latest in gene-sequencing technology and computational analysis to collect and investigate genetic sequences and variations of every gene expressed by 1,000 tumors. They are identifying genetic patterns within tumors that may help predict how cancers behave. Many experts believe such information will increasingly guide treatment. Charles Pelizzari, PhD, associate professor of radiation and cellular oncology, and his team of medical physicists are investigating the latest in advanced, image-guided radiation equipment and procedures. For example, they are optimizing intensity-modulated radiotherapy (IMRT), which uses computer-generated images to create 3D tumor models. IMRT allows clinicians to alter the radiation dose according to body tissue thickness to ensure that healthy tissues receive only a modest dose or none at all. 12 As advanced technologies become more intricate, robust, and multifaceted, they also become more costly to purchase and maintain. The UCCCC and the Biological Sciences Division work together to develop centralized centers of expertise and provide researchers access to a comprehensive set of technical resources. The UCCCC supports 12 of the more than 20 shared research facilities serving a variety of scientific disciplines. The newly formed Research Resources Oversight Committee (RROC), chaired by UCCCC Director Michelle M. Le Beau, PhD, works with Jim Schilling, PhD, the new director of the Office of Shared Research Facilities (OSRF), to manage and oversee these facilities. UChicago frequently upgrades its shared research facilities and resources to provide scientists with state-of-the-art technologies. In the past year, for example, Anne Sperling, PhD, associate professor of medicine, and the scientific director of the Flow Cytometry Facility, acquired a $420,000 Amnis Image Stream Analyzer, supported by NCI American Recovery and Reinvestment Act funds. The advanced technology sorts and analyzes individual cells by guiding particles into a single, fluid stream that passes through a detection system that measures physical and/or chemical characteristics of each particle. The technology is superior to earlier analyzers because of, for example, its enhanced ability to measure genetic abnormalities associated with leukemia, breast cancer, and other cancers. UCCCC researchers are taking full advantage of technologies like flow cytometry, IMRT, genesequencing, advanced computational analyses, and micro-western arrays to expand our scientific knowledge and shorten the time required to translate discoveries into clinical application. The UCCCC and the Biological Sciences Division work together to develop centralized centers of expertise and provide researchers access to a comprehensive set of technical resources. Leading-edge technologies help advance innovative ideas and discoveries that translate into superior patient care. Steven Chmura, MD, PhD Richard Jones, PhD Abraham Dachman, MD UCCCC Members Earn National Honors The many distinctions awarded to our UCCCC members this past fiscal year reflect the high regard of their peers. This list provides a small sample of the many honors our members received: Stephen L. Archer, MD—President-elect of the American Heart Association (AHA) Metro Chicago Board of Directors Maryellen L. Giger, PhD—Chair of the American Association of Physicists in Medicine (AAPM) Executive Committee and Member of the National Academy of Engineering (NAE) David Grdina, PhD, MBA—Member of the NASA Space Radiation Standing Review Panel UCCCC 2009–2010 Annual Report n Geoffrey L. Greene, PhD—Komen Brinker Award for Science Distinction Hedy Kindler, MD— Asbestos Disease Awareness Organization (ADAO) Selikoff Lifetime Achievement Award Olufunmilayo I. Olopade, MBBS, FACP—Fellow of the American Academy of Arts and Sciences (AAAS) Mark J. Ratain, MD—American Association of Pharmaceutical Scientists (AAPS) Research Achievement Award in Clinical Pharmacology and Translational Research Janet D. Rowley, MD, DSc—National Academy of Sciences (NAS) Jessie Stevenson Kovalenko Medal and American Association for Cancer Research (AACR) Lifetime Achievement in Cancer Research Award cancer.uchicago.edu Richard Schilsky, MD—James Ewing Lecture for the Society of Surgical Oncology and Founders Lecture for the Society for Clinical Trials Kerstin M. Stenson, MD, FACS— Fellow-at-Large of the American Head and Neck Society Council Wendy Stock, MD—Co-Chair, National Cancer Institute (NCI) Leukemia Steering Committee and member of the American Board of Internal Medicine (ABIM) Hematology Subspecialty Board Everett Vokes, MD—Member of the American Society of Clinical Oncology (ASCO) Board of Directors 13 Outreach Programs Help Strengthen Ties with Community Community outreach, especially to underserved populations, is fundamental to the success of a comprehensive cancer program. Karen Kim, MD, MS The UCCCC Cancer Resource Center, in partnership with the American Cancer Society, assists individuals with cancer and their families by offering information, access to support groups, and other services. Mary Herbert (left) is a certified health education specialist and Kimberly Nelson, LPC (right), is a licensed professional counselor. 14 For more than 5 years, the UCCCC, in collaboration with The University of Chicago Medical Center (UCMC), has built partnerships with local communities and has diligently sought to understand and meet the needs of its neighbors in Hyde Park and the surrounding communities. Essential to the UCCCC’s outreach efforts is an innovative program called Community Engagement Centering on Solutions (CECOS)—recently renamed the UCCCC Office of Community Engagement and Cancer Disparities with Karen E. Kim, MD, MS, as its new director—which enhances public awareness about cancer prevention, early cancer detection and control, the role of genetics in cancer, and the importance of participation in clinical trials. Not only does the program educate individual participants, but also provides the skills necessary so that community leaders can continue to disseminate important health information long after the events are completed. During the 2009–2010 fiscal year, CECOS hosted three public forums—two on cervical cancer and the human papillomavirus (HPV) and one on hepatitis and liver cancer. The forums on cervical cancer and HPV, called “Our Daughters, Our Duty” were held in November 2009 at Richard J. Daley College, on Chicago’s Southwest Side, and in March 2010 at Kennedy-King College, on Chicago’s South Side. In each case, about 100 people attended and asked questions covering topics from signs and symptoms of cervical cancer to the HPV vaccine. In May 2010, CECOS hosted “Break the Silence: Let’s Stop Hepatitis and Liver Cancer in our Communities!” at Truman College on Chicago’s North Side. The forum focused on Hepatitis B and C, their connection to liver cancer, and their impacts on the people of Asian and Pacific Islander heritages. The forum also included personal testimony from community health workers and liver cancer patients. UCCCC 2009–2010 Annual Report n cancer.uchicago.edu “The education gained from these events is definitely bidirectional, valuable, and lasting,” said Dr. Kim, UChicago associate professor of medicine, who led the hepatitis and liver cancer event. “Sharing stories, teaching, and learning from community members will allow us to go back to the lab and address barriers using the perspective of those whose lives we are determined to improve.” In the Bronzeville neighborhood, CECOS continued its program at the Bronzeville Farmers Market to promote cancer prevention and healthy eating. CECOS also participated in Pearl Fest, an annual outdoor festival hosted by Little Black Pearl, an organization that aims to empower children through art and entrepreneurship. At the August 2009 event, CECOS provided dozens of men with free prostate screenings through a UCCCC collaboration with Clear Channel Communications, Inc., and the Illinois Department of Public Health. The UCCCC reached out to the community in many other ways over the past fiscal year, including providing cooks for Real Men Cook– Chicago, planting a garden at the Emmett Louis Till Math & Science Academy on Chicago’s South Side, distributing food to the needy at local food pantries, and raising money for cancer research. The UChicago Walk and Roll team, led by M. Eileen Dolan, PhD, professor of medicine, and Lee Baksas of the UCCCC staff surpassed its fundraising goal of $10,000 by raising $12,500 for the American Cancer Society. The combined total of $17,600 for all six UChicago teams was in the top 10 overall and #1 among participating not-for-profits. With its new name and Dr. Kim taking over responsibilities as program director, the new UCCCC Office of Community Engagement and Cancer Disparities will increase its reach and positive impact on the community during the coming years. In the Bronzeville neighborhood, CECOS continued its program at the Bronzeville Farmers Market to promote cancer prevention and healthy eating. Lee Baksas and M. Eileen Dolan, PhD Find us on Facebook and Twitter! The UCCCC expanded its outreach via social media this fiscal year. Fans and followers learned about everything from tips to prevent skin cancer, to karaoke night to raise money for cancer research, to the latest news in cancer treatment at UChicago. 15 Report from the Cancer Registry Making appropriate decisions in oncology and public health is based on reliable data collection of cancer incidence, treatment, stage-specific survival, and end results. At the UCCCC, the Cancer Registry Unit—a major component of our American College of Surgeons-approved program and National Cancer Institute (NCI)-designated Comprehensive Cancer Center—has documented the impact of cancer by gathering detailed information on patients treated at The University of Chicago Medical Center (UCMC) for this disease since the 1920s. Early cancer registry books often included handwritten details about a patient’s name, account, and diagnosis. 16 Cancer Registry Manager Cassie Simon, CTR, leads a team of data management specialists to ensure that complete, accurate, and timely abstracting is achieved for each oncology patient diagnosed or treated at the UCMC. Patient demographics, primary site, histology, stage of disease, treatment, and outcomes are collected and recorded in a designated, specifically configured database. Quality control mechanisms support the meaningful evaluation and analysis of these vital statistics that are provided in customized reports for our cancer researchers and administrative staff, as well as state and national cancer surveillance programs. In the past year, the Cancer Registry successfully completed 63 requests for data, which were used in epidemiologic and health disparity grant proposals, childhood pediatric cancer survivor studies, and cancer program planning initiatives, such as the expansion of our physician resident program and pathology labs, Breast Cancer Consortium, Translational Data Mart (TraM) database, and Cancer Survivors Day, as well as several cutting-edge cancer research studies. In addition to incidence reporting, the Registry also plays an active role on the Cancer Committee. Chaired by Kevin Roggin, MD, FACS, associate professor of surgery, the committee provides oversight and promotes excellence among our interdisciplinary cancer departments and ensures that the standards for our American College of Surgeons cancer program accreditation are maintained. Recognized by U.S. News & World Report and currently ranked #15 in the nation—the highest ranking of any institution in Illinois—our cancer program remains unwavering in our ongoing commitment to provide high-quality cancer care to our patients and community. 2009 UCMC Cancer Data Types of Cancer Table 1 reveals that 3,408 patients were diagnosed and/or treated for cancer at the UCMC in 2009. Of these, 2,847 (83.5%) were new diagnoses and 561 cases (16.5%) were initially treated elsewhere and referred to the UCMC for recurrent or progressive disease. The most frequently seen, by primary subsite, include prostate (619 patients), lung and bronchus (320 patients), breast (351 patients), colorectal (191 patients), and kidney/renal pelvis (158 patients). Table 1: 2009 UCMC Cancer Cases by Site Primary Site Newly Diagnosed Recurrent/ Progressive Disease Total % of Total Cases Oral Cavity & Pharynx 128 41 169 5.0% Respiratory System* 322 44 366 10.7% Digestive System 523 96 619 18.2% 36 8 44 1.3% Mesothelioma Bones & Joints 20 5 25 0.8% Soft Tissue (Includes Heart) 41 11 52 1.5% Skin (Excludes Basal & Squamous Cell) 56 20 76 2.2% Breast 302 49 351 10.3% Female Genital System 125 46 171 5.0% Male Genital System 578 63 641 18.8% Urinary System 252 52 304 8.9% 53 8 61 1.8% 142 24 166 4.9% 95 38 133 3.9% Brain & Other Nervous System Endocrine System Lymphoma Multiple Myeloma 31 7 38 1.1% Leukemia 94 27 121 3.6% Miscellaneous 49 22 71 2.0% Total Cases** 2,847 561 3,408 100% * Includes larynx. ** Excludes 59 benign brain and endocrine tumors. The University of Chicago Medical Center 2010 Cancer Committee Kevin Roggin, MD, FACS, Chair Associate Professor of Surgery Hiroyuke Abe, MD, PhD Assistant Professor of Radiology Habibul Ahsan, MD, MMedSc UCCCC Associate Director for Population Research Professor of Health Studies, Medicine, and Human Genetics Ramona Behrendt, LCSW, OSW-C Oncology Social Worker, Social Services Department Sally Black, RN, MSN, MBA, OCN Clinical Director for Hematology/ Oncology, UCMC Brian Chiu, PhD Associate Professor of Health Studies UCCCC 2009–2010 Annual Report Steven Chmura, MD, PhD Assistant Professor of Radiation and Cellular Oncology Mary Herbert, BBS UCCCC Program Manager, Cancer Resource Center Marcy A. List, PhD UCCCC Associate Director for Administration Scientific Director, Cancer Clinical Trials Office Rebecca Malloy, RN, BSN Philip Hoffman, MD Professor of Medicine Autologous Stem Cell Transplant Administrator, Department of Medicine Aliya Husain, MD Patricia McBride, RHIT, CTR Gita Rupani, MD Assistant Professor of Anesthesia & Critical Care Cassie Simon, CTR Manager, Cancer Registry Gary Steinberg, MD Bruce and Beth White Family Professor of Surgery Chief, Urologic Oncology Assistant Director for Health Information Management Regine Theodule, BA, CTR Associate Professor of Medicine Cancer Liaison Physician Director, UCCCC Office of Community Engagement & Cancer Disparities Kenan Onel, MD, PhD S. Diane Yamada, MD Victor Lagroon Blase Polite, MD, MPP Professor of Pathology Karen Kim, MD, MS Coordinator, UCCCC Office of Community Engagement & Cancer Disparities n cancer.uchicago.edu Assistant Professor of Pediatrics Jayant Pinto, MD Assistant Professor of Surgery Registrar, Cancer Registry Associate Professor of Obstetrics & Gynecology Chief, Section of Gynecologic Oncology Assistant Professor of Medicine 17 Patient Demographics At the UCMC, a majority of patients (53.3%)—both male and female—are diagnosed with cancer between the ages of 50 and 69 years of age (See Figure 1). Distribution by gender and race (See Figure 2) reveals the ethnically diverse population that we serve. The majority of our cancer population is White (66.0%, 2,250 patients), followed by Black (26.3%, 897), and Hispanic (3.4%, 117 patients). Patient Geographics Distribution by residence or county at initial diagnosis (See Diagram 1) reveals that a majority of Figure 1: 2009 UCMC Cancer Cases by Gender and Age at Diagnosis patients (81%, 2,774 patients) are Illinois residents with the highest frequencies seen in Cook County (65.8%, 1,825 patients), DuPage County (8.6%, 239 patients), Will County (7.0%, 194 patients), Lake County (6.8%, 188 patients), and Kane County (2.2%, 60 patients). The remaining populations (19%, 634 patients) reside outside the State of Illinois, with the highest incidence of non-Illinois residents from the neighboring states of Indiana (75.3%, 478 patients), Michigan (8.0%, 51 patients), and Wisconsin (4.9%, 31 patients). Four patients traveled from other countries—Turkey, Serbia, Saudi Arabia, and Israel. Figure 2: 2009 UCMC Cancer Cases by Gender, Race/Ethnicity 700 1,500 600 1,200 Number of cancer cases Number of cancer cases 500 400 300 900 600 200 300 100 0 0 0-29 Male 30-39 40-49 50-59 60-69 70-79 80-89 90+ White Black Oriental Hispanic Female Male Female Asian Unknown Indian or Pakistani, NOS Diagram 1: 2009 UCMC Patient Residence at Diagnosis Illinois Residents by County 478 (75.3%) Indiana 60 (2.2%) Kane 51 (8.0%) Michigan 188 (6.8%) Lake 194 (7.0%) Will 239 (8.6%) DuPage 18 Non-Illinois Residents 1,825 (65.8%) Cook 2,774 (81%) 634 (19%) 31 (4.9%) Wisconsin 4 (2.2%) Outside of U.S.: Turkey, Serbia, Saudi Arabia and Israel A Focus on Head & Neck Cancer The Head and Neck Cancer Program is dedicated to comprehensive care that includes screening, prevention, treatment, and rehabilitation, and combines the expertise and resources of a multidisciplinary team. The University of Chicago Medical Center (UCMC) is an internationally renowned, high-volume referral center for the treatment of head and neck cancer, including cancers of the sinuses, mouth, tongue, tonsils, pharynx, larynx, upper esophagus, thyroid, and salivary glands. Our research has pioneered concepts that are now considered standards of care, such as concurrent chemotherapy and radiation therapy (chemoradiotherapy), that result in preservation of critical organs and their function, such as speech and swallowing. Studies conducted at the UCMC have shown that chemoradiotherapy provided complete control of locally advanced head and neck cancer for more than 90% of patients and provided a 3-year survival rate of 70%. These rates are twice the survival rates for advanced disease treated with traditional therapy. The UCMC Head and Neck Program is among the best because our clinical and research teams continue to refine therapies and challenge the norm to obtain the best patient outcomes. Our multidisciplinary tumor board meets exclusively to discuss head and neck cancer cases. Members of the Head and Neck Tumor Board represent many specialties, including medical oncology, endocrinology, radiation oncology, surgery, pathology, neuroradiology, dentistry, social work, nursing, and speech and swallowing therapy. Our medical oncology team is co-directed by Everett Vokes, MD, who has had a highly visible career in clinical and translational research involving head and neck cancer and the interaction of chemotherapy and radiation, and Ezra Cohen, MD, who UCCCC 2009–2010 Annual Report n cancer.uchicago.edu is also an expert in head and neck cancer as well as in developing novel cancer therapies. The medical oncology team’s work has shown that intense treatment combining radiation and chemotherapy can bring locally advanced head and neck cancer under control and improve survival. They have also developed targeted therapies designed to minimize side effects and maximize tumor destruction. From Research to Practice Our research has found that patients with advanced tongue cancers may be spared total glossectomy (removal of the tongue) through innovative chemoradiotherapy techniques (Stenson, et al., Laryngoscope 120:93-9, 2010). In addition, we have established techniques that minimize the surgical risk and postoperative effects of neck dissection (removal of lymph nodes for pathologic analysis) after chemoradiotherapy while gaining the most information for prognosis (Langerman, et al., Arch Otolaryngol Head Neck Surg. 135:876-880, 2009; Arch Otolaryngol Head Neck Surg. 135:1133-1136, 2009). Our investigators have applied novel molecularly targeted agents to the advanced disease setting. They were the first to combine a new class of drug, epidermal growth factor receptor (EGFR) inhibitors, with chemoradiotherapy and demonstrated that the regimen was well-tolerated with high cure rates in patients with Stage III or IV disease (Cohen, et al., JCO 28:3336-3343, 2010). In addition, investigators have identified groups of patients who may respond poorly to EGFR inhibitors and are developing new therapies to treat these individuals. Photomicrograph of squamous cell carcinoma tumor cells invading the skeletal muscle of the tongue. 19 Figure 3: UCMC Head & Neck Cancer Patients, 2005–2009 Figure 4: 2009 Newly Diagnosed Head & Neck Cancer Patients by Gender, Age at Diagnosis 40 Nunmber of newly diagnosed patients 200 35 150 30 100 2006 2007 Treatment year 2008 2009 Number of patients 2005 Figure 5: Survival Rates for Head & Neck Cancers (All Sites Combined) Cumulative survival rate 100% 25 20 15 80% 10 60% 5 40% 0 20% 1 2 3 4 5 Years after diagnosis UCMC NCDB 0-29 Male 30-39 40-49 50-59 60-69 70-79 80-89 90+ Female NCDB Teaching/Research Source: National Cancer Data Base; cases diagnosed 1998–2002. Early Detection and Prevention The UCMC Head and Neck Cancer Program is a leader in integrating novel agents for treatment and prevention. Mark Lingen, DDS, PhD, has discovered that blocking angiogenesis (new blood vessel growth) in precancerous lesions can prevent the development of oral cancer. These findings are now being extended to clinical trials for individuals at greatest risk for developing oral cavity cancers. Dr. Lingen and Elizabeth Blair, MD, are using new technologies, such as autofluorescence, to detect precancerous lesions in the mouth and throat. In our High Risk Oral Cancer Clinic, we offer extensive screenings to patients with suspicious lesions and to those with an elevated risk of a second cancer. Our patients are educated about the signs and symptoms of head and neck cancer, as well as ways to reduce contributing risk factors, such as quitting smoking and reducing alcohol consumption. Hope for the Most Complex Cases Patients with recurrent or persistent cancer are the most challenging. For many of these patients, the latest organ-sparing therapies have not been 20 effective. The UCMC offers additional options. Daniel Haraf, MD, MS, is a pioneer in second courses of radiation therapy, something previously considered impossible due to its severe side effects. Our medical oncology team, including Drs. Vokes, Cohen, Tanguy Seiwert, MD, and Victoria Villaflor, MD, help craft treatment strategies for the toughest cases. These treatments include advanced, computer-directed intensity-modulated radiation therapy (IMRT) which delivers radiation to a precise area while sparing surrounding normal tissue. Our head and neck surgeons, including Kerstin Stenson, MD, Louis Portugal, MD, and Dr. Blair, specialize in the complex removal of tumors while leaving intact critical blood vessels, nerves, and other structures. In some cases, new organs are created using tissue transferred from other parts of the body. The reconstructive plastic surgery team is led by Lawrence Gottlieb, MD. With our knowledgeable experts, state-of-theart technologies, and leading-edge research, The University of Chicago is an international leader in head and neck cancer cases, especially those referred by other institutions. Our team is Table 2: 2009 Head & Neck by Site, Gender, Class of Case, and AJCC Stage Group Sex Primary Site Class of Case Stage Distribution – Analytic Cases Only Non Analytic Analytic Stage 0 Stage I Not AJCC Stageable Unk. Stage 18 0 1 5 24 0 0 Total (%) M F Tongue 49 (23.2%) 33 16 38 11 0 10 7 2 Tonsil 35 (16.6%) 30 5 31 4 0 1 1 Stage II Stage III Stage IV Larynx 30 (14.2%) 22 8 23 7 1 3 3 6 10 0 0 Gum & Other Mouth 29 (13.7%) 16 13 21 8 0 8 4 0 9 0 0 Salivary Glands 20 (9.5%) 13 7 11 9 0 2 1 4 4 0 0 Other Oral Cavity & Pharynx, NOS 14(6.6%) 11 3 11 3 0 0 0 0 0 11 0 Nose, Nasal Cavity & Middle Ear 12 (5.7%) 10 2 8 4 0 0 3 1 1 3 0 Hypopharynx 8 (3.8%) 7 1 7 1 0 0 2 0 5 0 0 Nasopharynx 6 (2.8%) 3 3 4 2 0 0 0 2 2 0 0 Oropharynx 5 (2.4%) 3 2 2 3 0 0 0 0 2 0 0 Floor of Mouth 3 (1.4%) 1 2 3 0 0 1 0 1 1 0 0 211 149 62 159 52 1 25 21 21 76 14 1 Total also recognized for its extraordinary dedication to helping patients maintain the best possible quality of life during and after treatment. Head and Neck Cancer Stats From 2005 to 2009, the number of newly diagnosed head and neck cancer patients at the UCMC rose 19% from 134 patients in 2005 to 159 patients in 2009. (See Figure 3). head and neck cancer. Among them were 88 men (55.4%) over the age of 50 years. (See Figure 4). Figure 5 shows 1- to 5-year survival rates for patients diagnosed with stage IV head and neck cancers. Survival rates are shown for patients treated at the UCMC compared with national survival rates and those of teaching and research hospitals. In 2009, 211 patients were seen for head and neck malignancies. Of these, 149 (71%) were male and 62 (29%) female. A total of 159 patients (75%) were newly diagnosed and 52 (25%) were treated at the UCMC for recurrent or progressive disease. In Table 2, American Joint Committee on Cancer (AJCC) Staging is displayed for the newly diagnosed or analytic patients and reveals that 48% (76 patients) were diagnosed in the latest stage (IV) of this disease. Head and neck cancers account for approximately 3% to 5% of all cancers in the United States, according to the American Cancer Society. Nationally, men age 50 years and older have a higher chance of being diagnosed with a head and neck cancer than women. At the UCMC in 2009, a total of 159 patients were diagnosed with UCCCC 2009–2010 Annual Report n cancer.uchicago.edu UChicago head and neck cancer surgeon Kerstin Stenson, MD, reviews a patient’s scan. 21 Team Approach Creates Top-Notch Head and Neck Cancer Treatment Outcomes “We have learned that if we are more aggressive with our therapy upfront, there is a better outcome for our patients.” — Elizabeth Blair, MD The University of Chicago is renowned for its innovative treatments and better-thanaverage outcomes for head and neck cancer patients, especially those treated with concurrent chemotherapy and radiation therapy, a technique pioneered at UChicago. Studies conducted at The University of Chicago Medical Center found that this therapy, now a standard of care, has provided complete local control of advanced head and neck cancer for more than 90% of UChicago patients and an 80% longterm survival rate without disease progression. That is why, when a Fort Wayne, Indiana, orthodontist had a second recurrence of head and neck cancer, he made the 3 hour drive to The University of Chicago. “I wouldn’t be alive today if I hadn’t come to UChicago,” said James Williams, DDS. It was the summer of 2002, when Williams was 55 years old, that he found a nodule in his neck. Because he did not have any other symptoms, such as swallowing problems, he waited 3 months before he saw a doctor. He was diagnosed with squamous cell carcinoma in his tonsil. He had surgery and 7 weeks of radiation therapy, during which he never missed a day of work. Eighteen months later, he had trouble swallowing and learned his cancer had returned. Williams underwent a supraepiglottic laryngectomy, which is surgery to remove part of the epiglottis and the voice box. Less than a year later, the cancer had spread to his tongue. It was fall 2005 when Williams first came to UChicago. Radiation oncologist Daniel J. Haraf, MD, MS, and medical oncologist Ezra Cohen, MD, administered a second course of radiation and chemotherapy, which has left 22 Williams cancer free, but 3 years of cancer treatments and surgery resulted in multiple lifethreatening infections and damage to the neck tissue making it difficult to swallow or talk. Head and neck surgeon Elizabeth Blair, MD, and plastic surgeon Lawrence Gottlieb, MD, worked together to perform a laryngectomy and reconstruct Williams’ neck and esophagus grafting tissue from his thigh. Speech and swallowing therapist Ellen MacCracken, MS, immediately began creating a rehabilitation plan. “So after 3½ years of not being able to eat by mouth, I got that function back and no longer have a feeding tube protruding out of my belly,” said Williams. “From a patient’s perspective that was a huge improvement in the quality of my life. There are not many facilities that can provide this level of care.” Williams, who now uses voice prosthesis, is very active. “I’m a Type A personality. The worst thing you can do to me is make me stay still,” he said. Williams’ wife Diane said she cannot give enough praise to the UChicago staff. “Everyone from the physicians to the nurses and other members of the healthcare team were really efficient and helpful,” she said. “They all communicated with each other and taught me what I needed to do to change Jim’s bandages and give him other treatments while he was at home. The doctors and staff regularly checked in with us—whether we contacted them or they contacted us—and they responded to our e-mail questions within 24 hours. Living 3 hours from Chicago, communication in every way has been important to us.” The success story is even better for retired North Shore lawyer John Lynch, who has been cancer free for nearly 2 years. Already a survivor of melanoma, Lynch is acutely aware of his body. In October 2008, when Lynch was shaving and noticed a bump the size of a raisin on his neck, he made an appointment with his primary care physician. The physician initially prescribed antibiotics and later referred him to an ear, nose, and throat specialist. Several tests and a biopsy showed Lynch had squamous cell carcinoma; however, because of some unsettled feelings about how his case was being handled, Lynch brought his slides to the doctor who treated him for melanoma. Lynch was told that it was cancer, but that the tumor was a secondary malignancy, not the primary source. Lynch was referred to the head and neck cancer team at UChicago. “I feel very privileged to have been treated by Drs. Blair and Haraf, and the rest of the team,” said Lynch. “They worked together and independently to find the primary source of the tumor, and Dr. Blair operated on Christmas Eve 2008.” The tumor had grown, so Dr. Blair also had to remove some of his lymph nodes, tonsils, and some of his inner cheek. Lynch went home on Christmas day, returning 2 weeks later to see Dr. Haraf and begin radiation therapy and chemotherapy. Throughout the process, Lynch continued to eat—milk shakes, mashed potatoes, and other soft foods—which he said helped set the tone for a good quality of life. “I have some minor problems like dry mouth and salivary blockages, but I feel great,” Lynch said. “I’m very active.” Dr. Blair credits the overall care that UChicago provides for the successful outcomes seen in many head and neck cancer patients. “When we talk about being a comprehensive cancer center, it’s not enough to just perform chemotherapy and radiation therapy,” explained Dr. Blair. “The surgery and helping a patient manage really important functions, like using their voice and swallowing, is a big part of the quality of care. We have learned that if we are more aggressive with our therapy upfront, there is a better outcome for our patients.” She said regular communication among the oncologists, radiation therapists, surgeons, and speech and swallowing therapists is also important. Elizabeth Blair, MD, and patient John Lynch, JD, meet every few months to review his treatment progress. They are pictured on the Main Quadrangles of the UChicago campus. “We don’t hesitate to question or challenge or critically review what we do and what our results are,” she said. “It is a healthy, team environment that makes it better for our patients.” From a patient perspective, both Williams and Lynch said they feel lucky to have been treated at UChicago. “I was never worried— not for even a single day,” said Lynch. Members of the Multidisciplinary Head and Neck Tumor Board meet every Tuesday morning to discuss treatments for new patients, as well as the progress of existing patients. (Seated from left) Wendy Cortez, RN, Allison Dekker, RN, Nedra Joyner-Triplet, MD, Daniel Haraf, MD, MS, Elizabeth Blair, MD, Carley Demchuk, and Andrew Kaufman. (Standing from left) Louis Portugal, MD, Ezra Cohen, MD, Jessie Aw, MD, Valerie Reynolds, Maureen Crowley, NP, Jeffrey Mueller, MD, Mary Ellyn Witt, RN, MS, Colin Poon, MD, Nancy Ellis, RN, Everett Vokes, MD, Gairta Bartos, Victoria Villaflor, MD, Theresa McClendon, Patricia Heinlen, RN, Rebecca Brown, MD, Kerstin Stenson, MD, and Ellen MacCracken, MS. Not pictured: Mark Lingen, DDS, PhD, Tanguy Seiwert, MD, Jerome Taxy, MD, and Ralph Weichselbaum, MD. The UChicago Otolaryngology/Head and Neck Surgery team includes (from left) Louis Portugal, MD, Elizabeth Blair, MD, Kerstin Stenson, MD, and Nedra Joyner, MD. UCCCC 2009–2010 Annual Report n cancer.uchicago.edu Patient James Williams, DDS (center), with two members of his treatment team, Lawrence Gottlieb, MD, and Elizabeth Blair, MD, in a common area of the Duchossois Center for Advanced Medicine. 23 Foundation Makes Significant Contribution to Cancer Research Generous Support Keeps UChicago ‘At the Forefront of Discovery ’ TM We are extremely grateful to our boards for their diligence and dedication to supporting cancer research and advanced cancer care. We would also like to thank the community groups and individual donors, even some as young as 10 years old, whose contributions are helping UChicago make enormous progress in the fight against cancer. We are indebted to you for your generosity and for your understanding that today’s research is tomorrow’s cure. Ruth Ann Gillis McGuinnis President The University of Chicago Cancer Research Foundation Mary Ellen Connellan Executive Director The University of Chicago Cancer Research Foundation For more than six decades, The University of Chicago Cancer Research Foundation (UCCRF) has played a vital role in advancing the research that is making a significant, positive impact on the lives of cancer patients. Thanks to dedicated staff, very active volunteers, and generous donors, the UCCRF raised nearly $2.5 million in fiscal year 2009-2010. This money was used to fund more than 30 major basic and clinical cancer research projects, educational events, and prevention initiatives. Among those receiving UCCRF grants are: Thomas Gajewski, MD, PhD, professor of pathology and medicine, who is developing immune-based therapies for cancer; Ernst Lengyel, MD, PhD, associate professor of obstetrics and gynecology, who is creating new tests and treatments for ovarian cancer; and Justin Kline, MD, assistant professor of medicine, who is pursuing a vaccine and cellular therapies for acute myeloid leukemia (AML) patients. The UCCRF comprises four boards—one governance board (Board of Trustees) and three fundraising boards (Women’s Board, Auxiliary Board, Associates Board). The three fundraising boards host a variety of activities throughout the year from a spectacular Cancer Ball, to a disco chic dance, to a Texas hold’em poker tournament. In November 2009, CBS Evening News Anchor Katie Couric was the guest of honor at the Women’s Board Cancer Ball. She spoke about the importance of cancer prevention through regular screenings, such as colonoscopy. Her husband, Jay Monahan, died from colon cancer in 1998. The UCCRF presented Couric with its Partners in Discovery award to honor her crusade for early detection and 24 cancer awareness. More than 500 people attended the Cancer Ball at the Four Seasons Hotel Chicago. Each spring, the UCCRF hosts an elegant recognition dinner in honor of a researcher who has made important, long-term contributions to cancer research. The UCCCC awarded its 2010 Simon M. Shubitz Cancer Prize to pioneering stem cell researcher Irving L. Weissman, MD, from Stanford University in California. Earlier in the day, Dr. Weissman presented the Shubitz Lecture, “Normal and Neoplastic Stem Cells,” to UChicago faculty and students. In spring 2011, the UCCCC will honor Charles L. Sawyers, MD, from Memorial SloanKettering Cancer Center in New York, who was instrumental in the development of two drugs for leukemia and who is a leader in the study of drug resistance in prostate cancer. In addition to a corporate donation from Exelon, which helps fund UCCCC community outreach programs (See page 14), several community organizations themselves held fundraising events making generous donations to the UCCRF. These events included Riding for a Cure, Windy City Golf Classic, and the Arlington Million Ladies Luncheon. The UCCRF also launched a new way to raise money for cancer research that does not involve a direct monetary donation. The Foundation is now collaborating with tix4cause.com, a website that enables supporters to donate unused concert, symphony, opera, or sporting event tickets with 100% of the proceeds donated to the designated charity. A second such option launched in late 2010 is the Celebrated Chefs program through which designated restaurants will donate 5% of the bill from diners using a credit card registered with the program. 1 2 3 4 5 7 6 1 Michelle Le Beau, PhD (right), presents the Shubitz award to pioneering researcher Irving L. Weissman, MD. 2 The UCCRF Women’s Board celebrated five special women at a tea on June 8, 2010, at the Women’s Athletic Club in Chicago: • Mary Flynn—40 years of service (pictured left) • Kathryn Miller—40 years of service (pictured right) • Jean Atchison—25 years of service 3 Ten-year-old Rebecca Bleier (left) presented UCCCC Director Michelle Le Beau, PhD, with nearly $400—proceeds from her lemonade stand. Bleier made the donation in honor of her grandfather, who died from cancer. 4 (from left) Associates Board Member Tom McGrath, Thomas F. Gajewski, MD, PhD, and Associates Board President Justin Ullman at the Associates Board No Tie Ball held in October 2009 at the James Hotel. • Anne Hokin—25 years of service • Mary Conrad—work on the board’s annual appeal that has netted over $1 million since its inception in 1997 UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 5 Eugene Choi, MD (center), professor of surgery received $35,000 from the United-4 A Cure organization in support of his research on the progression and spread of gastrointestinal cancers, specifically pancreatic cancer. Dr. Choi is shown at a July 2009 presentation with supporters at the Riviera Country Club. 6 The 2009 trail ride for Riding For A Cure raised $45,000 for cancer research at the UCCCC. Event chair Tracy Gilman is seated on her mount with Christine Gabriel, founder of the Riding For A Cure Foundation. 7 The Zaccone Family Foundation has contributed $100,000 to The University of Chicago Cancer Research Foundation. Suzanne Zaccone’s battle with breast cancer was documented in last year’s annual report. (from left) Dominic “Bob” Zaccone, David Song, MD, MBA, FACS, Suzanne Zaccone, and Suzanne’s husband Lawrence Bostick. The donation will be used to support Dr. Song and his fellowship program in reconstructive microsurgery. 25 The University of Chicago Cancer Research Foundation Our Role in Fighting Cancer The University of Chicago Cancer Research Foundation (UCCRF) is a not-for-profit organization founded by retail store entrepreneur Maurice Goldblatt in 1946, following the death of his brother and business partner, Nathan Goldblatt, from cancer. The UCCRF raises money to support basic, clinical, translational, and population research programs related to the causes, prevention, diagnosis, and treatment of cancer at the UCCCC. Donations to the Foundation, both large and small: • Support innovative research that brings us closer to making cancer a manageable disease; UCCRF Board of Trustees Ruth Ann Gillis McGuinnis President Thomas J. Duckworth Vice President Barton G. Tretheway Treasurer Ms. Wende L. Fox Secretary Mary Ellen Connellan Executive Director Members John R. Atchison James N. Bay Jr. Margaret Benjamin Mrs. Seymour A. Cohen Richard W. Cusack John W. Derse Jr. Lidia Devonshire Mrs. Leonard S. Florsheim Jr. Stanford J. Goldblatt Charles P. Hammersmith Jr. Mrs. Michael Klein John A. Kuhlman Jr. Debbie Madlener Kathryn Miller Bruce Ovitz 26 • Enable the purchase of state-of-the-art equipment essential for scientific breakthroughs that enhance diagnosis and treatment; Lori Ovitz Justin Ullman Honorary Trustees Seymour A. Cohen Ronald L. Duitsman Leonard Lavin J. Clifford Moos UCCRF Women’s Board Officers Mrs. David W. Devonshire President Ms. Cynthia Reusché Special Advisor Mrs. Thomas C. D’Aprile First Vice President Mrs. David Nuelle Second Vice President Mrs. J. Mikesell Thomas Treasurer Nancy J. Knapp Program Chair Barbara C. Sessions Future Planning Chair & Nominating Chair Mrs. Gordon Lee Pollock Marketing & Communication • Expand the scope of cancer control and prevention efforts to save lives and diminish the harmful effects of cancer; and Mrs. Edward J. Miller Board of Trustees Liaison Mrs. Robert Conrad Ms. Anne H. Cox Annual Appeal Chairs Mrs. William Adams IV Ms. Becky Davidson Grand Auction Co-Chairs Mrs. Steven S. Helms Karen L. Manzari DreamHome Preview Party Chairs Mrs. Harris C. Brumfield Mrs. Michael Busch Mrs. J. Rowan Carroll Mrs. Henrik Clausen Mrs. John Derse Members-at-large of the Executive Committee Members Mrs. Alexander Anagnost Mrs. Helena Appleton Mrs. John R. Atchison Allison Bacon Mrs. James N. Bay Margaret Benjamin Mrs. Darcy Robert Bonner • Help train young scientists who will make discoveries that benefit our generation as well as generations to come. Mrs. James Brady Mrs. William R. Carney Mrs. Benjamin D. Chereskin Mrs. Gregory Chun Ms. Linda Burns Coleman Mrs. Benjamin Cox Mrs. Michael Crane Mrs. J. Michael Crouch Mrs. Richard W. Cusack Mrs. Andrew Da Miano Mrs. W. Brinkley Dickerson Jr. Linda Finkel Suzette Flood Ms. Susan Florence Mrs. Fahey Flynn Mrs. David W. Fox Mrs. Edward Gillette Mrs. Thomas T. Hall Mrs. Charles C. Harrold III Lesli K. Henderson Mrs. William J. Hokin Blaine Kinney Johnson Mrs. Thomas Eric Kilcollin Mrs. Donald A. King Jr. Mrs. Bernard J. Kompare Ms. Josephine Krug-Schulte Kristine Kurschner Ms. Amy Mazzolin Mrs. Andrew McGaan Robin Josephs McGarvey Mrs. McKay McKinnon Ms. Elissa Morgante Yoko Kusama Mosher Mrs. Stuart Oran Ms. Jody Oshita-Bajor Ms. M. Bliss Packer Shelley Johnstone Paschke Mrs. Kirby Pearson Mrs. Heber Pierce Wendy Chronister Rogers Mrs. Frank C. Schell III Mrs. James H. Schink Mrs. Gerald D. Skoning Ms. Nancy Voss Mrs. Keith Ward Mrs. William Wardrop Laura Werner Ms. Alice Williams-Verhoeven Honorary Members Mrs. Walter E. Auch Mrs. Wendy Becker-Payton Mrs. Robert R. Bell Mrs. Sharon Brix Mrs. Seymour A. Cohen Mrs. Leonard S. Florsheim, Jr. Mrs. Margaret Laun-Knauf Mrs. Arthur E. MacQuilkin Mrs. Charles W. Tallent Mrs. Charles Walgreen III UCCRF Auxiliary Board Laurie Baker Foster President Ann Mohn Treasurer Margo Calvetti Frost Secretary Jan Gaines Finance Debbie Madlener Foundation Liaison/Membership Annette Hickman Debbie Madlener Liz Tunney Williams Event Chairs Jackie Bossu Reservation Chair Kari Roever Ad Book Ginger Stambaugh Nancy Napalo Publicity Nancy Gupta Sustaining Member Liaison Sustaining Members Dr. Geraldine Balut Coleman Mrs. Robert Alan Conger Mrs. Jeffrey Diermeier Mrs. Gustav Horschke Mrs. Donald Horwitz Mrs. Robert D. Kimball III Mrs. Robert Kramer Mrs. Donald Levinson Mrs. Edward Liphardt Mrs. Michael McGuinnis Ms. Sandra Reese Mrs. Harry J. Smedley Jr. Mrs. John C. Stone Jennifer Kamp Tretheway Mrs. Leon E. Zygmun Active Members Celeste Alcock Cindy Alston Elizabeth Brandt Terri Kingdom n cancer.uchicago.edu Members Sustaining Members Leigh Beith Susan Bondurant Barbara Bridges Margaret Jacoby Becky Kolleng Joan Lancaster Betty Ann Manganaro Linda McCann Andrea Montross Helen Panje Jan Peterson Mary Helen Ray Patti Tyska Mary Clare White Honorary Members Cheri Allen Barbara Devlin Susan Fraley Darlene Landsittel Carol Lynnes Patsy McCurdy Barbara Schmolze Sharon Ubben Chris Youngberg UCCRF Associates Board Justin Ullman President Caroline Khadder Vice President CBS Evening News Anchor Katie Couric spoke about the importance of cancer prevention during the annual Women’s Board Cancer Ball. Couric also mingled with the 500+ event attendees at the Four Seasons Hotel Chicago. UCCCC 2009–2010 Annual Report Erin Callahan Secretary Darcy Bonner Treasurer April Krydynski Kathy McCarthy JoAnn McKibben Cathy Pratt Tierney Sharif Peggy Tieman Ann Wambach Midge Wegener Tearle Calinog Laura Cason Kim Coady Camille Cozzini Jamie Cusack Erica Diermeier Lindsay Essi Jeffrey Feste Chris Gilmore Suzanne Griffin Amiel Harper Julie Lissner Mike Logan Susan Loughran Tom McGrath Janelle Mentz Erin Ott Amanda Pierce Alex Reo Megan Robb Jordan Rovito Melissa Rutten Mike Ryan Taaron Silverstein Krishna Simonetti Jason Sochol Rob Soraparu Scott Stelzer Rachel Strassner Jenna Szkatulski Ashley Szybala Chaidan Upp At the 2010 DreamHome Preview Party at the Merchandise Mart (from left) UCCRF Executive Director Mary Ellen Connellan, DreamHome Co-Chair Lena Helms, Sheila Kennedy, Merchandise Mart President Christopher Kennedy, DreamHome Co-Chair Karen Manzari, and Merchandise Mart Executive Vice President John Brennen III. 27 2009–2010 Honor Roll of Donors The University of Chicago Comprehensive Cancer Center (UCCCC) gratefully acknowledges those who have generously supported cancer research and cancer-related programs and services at The University of Chicago. These donations help the UCCCC explore and develop innovative ways to prevent, diagnose, and treat cancer. The following alumni, friends, foundations, and corporations have demonstrated their extraordinary loyalty and commitment through leadership gifts. These gifts include cash, matching gifts, securities and property, pledges, and pledge payments received between July 1, 2009 and June 30, 2010. Director’s Leadership Circle $1,000,000+ American Cancer Society Cancer Research Foundation Anonymous (3x) The Duchossois Family Craig & Janet Duchossois Dick & Judi Duchossois Mr. & Mrs. Vincent W. Foglia Foglia Family Foundation Leukemia and Lymphoma Society Virginia and D.K. Ludwig Fund for Cancer Research Bruce & Beth White Diamond Circle $250,000–$999,999 ASCO Cancer Foundation American Cancer Society, Illinois Division Anagen Therapeutics, Inc. Avon Foundation The Breast Cancer Research Foundation Cancer and Leukemia Group B Foundation Cancer Research Institute Damon Runyon Cancer Research Foundation Ms. Becky Davidson Thomas J. Duckworth & Connie Duckworth Mrs. Arthur Edelstein 28 The Entertainment Industry Foundation G. Harold and Leila Y. Mathers Charitable Foundation Gabrielle’s Angel Foundation for Cancer Research Goldman Sachs Philanthropy Fund Phyllis Greene The Ralph and Marian Falk Medical Research Trust Carole B. & Gordon I. Segal The Searle Funds at The Chicago Community Trust Simmons Attorney at Law St. Baldrick’s Foundation The UCCRF Women’s Board Sapphire Circle $100,000–$249,000 Alliance for Cancer Gene Therapy American Institute for Cancer Research Anonymous Ben May Charitable Trust Crohn’s and Colitis Foundation of America Enivar Charitable Fund Estate of Marie Eileen Bratu Estate of Stephanie Wall Todak Estate of Thomas W. Neill / Ms. Amy M. Neill Fanconi Anemia Research Fund, Inc. Mr. Marc & Mrs. Carol Feliciano & Isabella & Antonio Feliciano Fidelity Charitable Gift Fund Flight Attendant Medical Research Institute The Francis L. Lederer Foundation Mr. Guy Delson Geleerd Jr. Mr. James D. Geleerd Ms. Judy Geleerd-Kitzes Mr. & Mrs. Richard Gonzalez Guy Geleerd Memorial Foundation Penny J. Hecktman & Jeffrey B. Hecktman and Hillary, Candace & Valerie Michael A. & Wendy J. Herst Mr. Todd Herst Leukemia Research Foundation Little Heroes Pediatric Cancer Research Foundation Melanoma Research Foundation Bernice* & Earl Meltzer Michael Rolfe Pancreatic Cancer Foundation Greg & Julie Moss MPD Foundation Ovarian Cancer Research Fund Prostate Cancer Foundation The UCCRF Auxiliary Board Zaccone Family Foundation Ruby Circle $50,000–$99,999 American Heart Association Alvin H. Baum Family Fund Bears Care Foundation Mr. & Mrs. Robert Berman Mr. & Mrs. Allan Bittker Brinson Foundation Burroughs Wellcome Fund The Charlotte Geyer Foundation Children’s Neuroblastoma Cancer Foundation Mr. & Mrs. Wiliam M. Connelly Mr. Jerome Contro Diermeier Family Foundation/ Mr. & Mrs. Jeffrey Diermeier The Dominick’s Charitable Foundation Gilbane Building Company Hologic, Inc. Lung Cancer Research Foundation Lymphoma Research Foundation Matthew Bittker Foundation Neuroblastoma Children’s Cancer Society Orthopaedic Research and Education Foundation Partnership for Cures Phi Beta Psi Sorority Mr. & Mrs. John B. Snyder Super Jake Foundation Trust Estate of Jean Sulzberger Meltzer Mr. Nicholas J. Vogelzang Jr. W. E. O’Neil Construction Company The Windy City Classic Foundation Platnium Circle $25,000 – $49,999 American Skin Association American Society for Blood and Marrow Transplantation American Society for Radiation Oncology (ASTRO) Anonymous Mr. & Mrs. James N. Bay Jr. Bear Necessities Pediatric Cancer Foundation The Ben and Catherine Ivy Foundation Boston Scientific Corporation Desmoid Tumor Research Foundation Jim & Karen Frank The Gynecologic Cancer Foundation K-Five Construction Corporation Susan G. Komen for the Cure Helen and Bernard Kozloff Family Foundation Dr. Mark & Mrs. Gale Kozloff Life Sciences Research Foundation Lisa Klitzky Foundation Mr.* & Mrs. Norman Matthew Ms. Nora Groh McKinley Multiple Myeloma Research Foundation Neph Rx Corporation The Neuberger Berman Foundation Radiological Society of North America Reinhold and Lucille Groh Foundation Riding For A Cure Mr. Anthony Santacroce Ms. Josephine M. Krug & Mr. Gerard Schulte Mr. Randall Svendsen Jill & John Svoboda The UCCRF Associates Board Valda and Robert Svendsen Foundation Ms. Marie Wilkinson Mr. & Mrs. Robert A. Wilson Mrs. Harry Woldenberg Gold Circle $10,000–$24,999 Mr. & Mrs. William Adams IV Mr. & Mrs. Bruce Anderson Anonymous Arlington Million Ladies Barclays Capital Barnabas Foundation Mr. & Mrs. Dean P. Bergman Mr. & Mrs. James Bozik Brian Delanty Invitational Mr. & Mrs. Harris C. Brumfield Carson Family Foundation Ms. Kathleen E. Chapski Charles Hammersmith and Carol Hammersmith Family Foundation Mr. & Mrs. Benjamin Chereskin Chicago White Sox Charities, Inc. Mr. & Mrs. Andrew Da Miano Mr. Steve Delanty Mr. & Mrs. David W. Devonshire Earl and Brenda Shapiro Foundation The Earl Shapiro Family Estate of Florence McGuire Roe Exelon Corporation Dr. Leslie Gable & Ms. Hazel Fisher-Gable Friends of Cancer Research Mr. & Mrs. Robert Gelbort John & Charlotte Gilmore Mr. Charles P. Hammersmith Mr. & Mrs. Charles C. Harrold III Brien O’Brien & Mary M. Hasten Mr. & Mrs. Steven Helms Indiana Sports Charities John W. Anderson Foundation Junior Cancer League Kadrovach-Duckworth Family Foundation Katten Muchin and Zavis Foundation, Inc. Klein Tools, Inc. Mr.* & Mrs. Shalom Kohn Lady Tata Memorial Trust Andrea & Benjamin Leshem McDonnell Boehnen Hulbert and Berghoff LLP Mr. Andrew L. McGaan & Ms. Pamela L. McGaan Mr. & Mrs. Patrick McGarvey Merchandise Mart Properties Mr. Richard K. Mullin & Ms. Mary J. Mullin Chris & Carmi Murphy New Trier Swim Club Mr. & Mrs. David Nuelle Platform One Entertainment Ms. Diane Patricia Atwood & Mr. Paul J. Reilly Jr. Respiratory Health Association of Metropolitan Chicago Mrs. Cynthia M. Reusché Riviera Country Club and Sports Center Donations Support: Advanced imaging for earlier detection and improved treatment of breast cancer. Joan & Paul Rubschlager Saliba Family Charitable Foundation Inc. Mr. & Mrs. Anthony Saliba Mr. Harvey Schaffer Mr. Charles G. Schultz Mr. & Mrs. Rex Sessions Spastic Paralysis Research Foundation of the IllinoisEastern Iowa District of Kiwanis International Supera Family Foundation Terry Van Der Aa & Linda Van Der Aa Wendy Will Case Cancer Fund Mr. & Mrs. Michael Werner Mr. Jack C. Wetzel William Blair and Company Yen Chuang Foundation Dr. Yung-Tsai Yen & Mrs. Ho-Tzu Yen Silver Circle $5,000–$9,999 Mr. Christopher Abbinante Advisory Research Inc. Dr. Kris J. Alden & Mrs. Trisha Rooney Alden J. Douglas Bacon & Allison Bacon Baird Foundation, Inc. Mr. & Mrs. Robert B. Barr Mr. & Mrs. Jay Beaton Mr. & Mrs. Lawrence Benjamin Big Blue Swim School BMW of Schererville Mr. & Mrs. Frank S. Brumfield Mr. & Mrs. Michael J. Busch California Community Foundation Carleton College Ms. Roberta A. Conroy Mr. & Mrs. Benjamin Cox Mr. & Mrs. Michael E. Crane Ms. Carol K. Dugan Duk Young Foundation/ Mr. & Mrs. Gregory H. Chun Mr. & Mrs.* Edward Dunn Epic Systems Corporation Estate of Ruth G. Licklider Mr. & Mrs. Kevin F. Flynn Mr. & Mrs. Craig Hardwick Mr. & Mrs. Jerald Hoekstra The John and Charlotte Gilmore Foundation Jolan Foundation Corporation Kovler Family Foundation Live Oak Foundation Mr. John P. Lynch Mazzolin Family Foundation/ Ms. Amy Mazzolin Mr. & Mrs. Michael J. McGuinnis Moneris Solutions, Inc. Mr. J. Clifford Moos National Philanthropic Trust Mr. Stephen D. Nechtow New Trier High School Boys Swimming and Diving New Trier High School Girls Swimming Lisa & Mark Pinsky Mr. & Mrs. John R. Raitt Searle Family Trust The Sidley Austin Foundation Chris & Elaine Simadis Mr. Robert Swartz Trading Technologies International, Inc. Mr. & Mrs. Donald L. Ullman Mr. & Mrs. James M. Weichselbaum Ms. Ondrea C. Weikum Ellen S. Alberding & Kelly R. Welsh Bronze Circle $2,500–$4,999 Chris E. & Martha M. Abbinante Anonymous Ms. Keli L. Arnold Mr. & Mrs. Peter Bajor Balkin Family Foundation Mr. & Mrs. Michael Balkin Blum-Kovler Foundation, Inc. Bolton Sullivan Fund Mr. & Mrs. Darcy Robert Bonner Cancer Sucks Merchandise Chicago Luxury Beds Mr. & Mrs. Henrik Clausen Mr. & Mrs. David L. Cole Mr. & Mrs. Thomas L. Cox Mr. & Mrs. John W. Derse Jr. Mr. & Mrs. Geoffrey Dixon Donald and Bonnie Maharam Charitable Foundation *Deceased UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 29 2009–2010 Honor Roll of Donors Mr. Dennis Drescher Mr. & Mrs. Ronald L. Duitsman Mr. & Mrs. Louis A. Ebert Estate of Lillian Z. Bronkhurst Mr. Thomas L. Fritzlen Jr. Dr. & Mrs. Damien A. Gabis Gene and Georgetti Grant Thornton LLP Mr. & Mrs. Michael C. Henkel Mr. & Mrs. William J. Hokin Illinois Organization of Mothers of Twins Club Mr. Scott W. Jones Ms. Susan Keeler Mr. & Mrs. Thomas E. Kilcollin Ms. Sara Kuehnrich Mr. David F. Mosher & Mrs. Yoko Kusama Ms. Wende L. Fox & Mr. L. James Lawson III Judy & Wayne Lewis Shutsung Liao, PhD Luther College Maurice H. Givens Charitable Trust Mr. & Mrs. Richard Melman Michigan Shores Club Mr.* & Mrs. Edward J. Miller MKMB Restaurant Partners LLC. Modestus Bauer Foundation Ms. Amy Morro Jan & Steve Nakovich Naperville Community Unit School District 203 Oppenheimer and Company Mr. & Mrs. James Nugent Perry Jr. Plum Creek Foundation Robert W. Baird and Co. Inc. Sacks Family Foundation/ Cari & Michael J. Sacks Mr. & Mrs. Frank Charles Schell III Mr. Thomas Siddons Mr. John P. Simon Michael & Diane Tang Mr. & Mrs. Barton G. Tretheway Jim & Eve Tyree Donations Support: Vanguard Charitable Endowment Program Mr. & Mrs. Samuel Zell Founders $1,000–$2,499 Almeida Family Foundation/ Mr. & Mrs. Richard Almeida Mr. & Mrs. Robert O. Anderson Anonymous Mr. & Mrs. John R. Atchinson Mr. & Mrs. George Babson Mr. & Mrs. Harold K. Baldwin Mr. & Mrs. Christopher Barber Mr. & Mrs. Shale D. Baskin Mr. & Mrs. Douglas Batchelor Ms. Ariadne P. Beck Mrs. William Belman Ms. Bonnie J. Benson Mr.* & Mrs. Louis A. Berger Mr. & Mrs. Alan Berkshire Ms. Suzanne Zaccone & Mr. Lawrence Bostick BP Fabric of America Fund Mr. James F. Brady & Mrs. Terese Eckelkamp-Brady Mr. & Mrs. Paul A. Branstad Braverman Family Foundation Mr. & Mrs. Neil Braverman Mr. & Mrs. Stephen J. Brewster Mr. & Mrs. Hardy T. Brumfield Mr. & Mrs. Samuel Buchsbaum John & Jackie Bucksbaum Mr. Zachary B. Bulwa Pauline M. Burelli Mr. & Mrs. Theodore Buzby Mr. Calvin C. Campbell Cancer Free America Foundation Mr. & Mrs. J. Rowan Carroll Mr. & Mrs. Stephen J. Casey Catholic Community Foundation Mr. & Mrs. Jack Chizmar Mr. & Mrs. Peter Clemens Mr. & Mrs. Mark Cloghessy Ms. Pamela Hanratty & Mr. Jeff Coburn Vani J. A. Konda, MD, and her work to develop novel markers and optical technologies that will help detect and treat colorectal cancer. 30 Mr. & Mrs. Neil Coleman Mr. & Mrs. Kevin M. Collins Mr. & Mrs. Kevin A. Connellan Mr. & Mrs. Robert L. Conrad Ms. Patricia O. Cox Ms. Meredith L. Manni Meserow & Mr. Sam Crawford Thomas C. & Nichole D. D’Aprile Ms. Helen B. Daigle Decorah Community School District Mr. & Mrs. Gilles Demeulenaere Mr. & Mrs. Charles Demirjian Denemark Peridontal Specialists, Ltd. Mr. & Mrs. Gary DiCenzo Mr. & Mrs. Richard F. Duffy Ms. Rose Mary Dupuy Mr. & Mrs. Ray Dybala Mr. & Mrs. Donald A. Eugenio Falls Church High School Robert & Joan Feitler Mr. & Mrs. John A. Ferguson Mr. Joseph Mathew Ferraro Mr. & Mrs. Robert Finkel Mr. Timothy A. Barrows & Mrs. Margaret A. Flanagan Dr. & Mrs. Timothy Flood Mr. & Mrs. David W. Fox Jr. Mr. & Mrs. Michael Frank Mr. & Mrs. Philip G. Franklin Friends of the Biological Sciences Mr. & Mrs. Brian Gelber Mr. & Mrs. James Gelbort Mr. John Giampoli The Gillette Foundation/ Mr. & Mrs. Edward S. Gillette Glenview State Bank Mr. & Mrs. Rodney L. Goldstein Dorothy and Freeman Gosden Jr. Foundation Grinnell College Mr. Austin L. Hirsch & Ms. Beth Gomberg-Hirsch The Greater Kansas City Community Foundation and Affililated Trust The Greer Foundation Mr. & Mrs. Hem C. Gupta Dr. & Mrs. Raj P. Gupta Mr. Timothy A. Hammond Herman and Florence Siegel Foundation Inc. Ms. Rachel Kohler & Mr. Mark Hoplamazian Hour of Power Mr. & Mrs. Timothy Hurd I Star Financial Inc. Illinois Prairie Community Foundation Mr. Kenneth M. Jacobson The Jaffee Foundation Jamison, Inc. Mr. & Mrs. Jan Jamison Mr. & Mrs. Sidney F. Jarrow Mr. Steven D. Jensen Mr. & Mrs. Rob Johnson Mr. & Mrs. Roger B. Johnston Mr. John C. Joyce Mr. Donald J. Kallin Ms. Carol W. Keenan Kirkland and Ellis Foundation Ms. Cynthia S. Heusing & Mr. David H. Kistenbroker Mr. & Mrs. Paul Raymond Knapp Mr. & Mrs. Vincent Anthony Kolber Mr. & Mrs. Neal Kottke Kovler Family Foundation Mr. & Mrs. Gilbert W. Kurschner Jr. Mr. & Mrs. John D. Lewis Mr. & Mrs. Michael Loiacano Mr. & Mrs. Cary Malkin Mr. & Mrs. Stephen P. Manus Mr. & Mrs. Tony Manzari Marziani Enterprises/ Mr. & Mrs. Thomas Marziani Ms. Nina B. Matis Matthew Lewis Foundation Mr. & Mrs. Richard F. McArdle Dr. & Mrs. McKay McKinnon Mr. & Mrs. Matthew Meiners Ms. Reggie Beckman & Mr. Timothy Merrill Merrill Lynch Michael and Cathleen Corey Charitable Fund Mr. & Mrs. Robert Johns Mignin Mr. & Mrs. Thomas Modrowski Mr. & Mrs. Michael J. Moore Mr. Richard Grunsten & Ms. Dehn Moon-Grunsten Morgante-Wilson Architects, LTD./ Ms. Elissa Morgante & Mr. Fred Wilson Ms. Evelyn Mueller Mr. & Mrs. William E. Mullin Mr. & Mrs. Bruce Mumford Neal, Murdock and Leroy, LLC Mr. R. Gregory Neidballa Bruce & Lori Ovitz Ms. Mary Bliss Packer Mr. Michael J. Palumbo Park National Bank Mr. & Mrs. Brett Paschke Mr. & Mrs. Marshall Peck Mr. Ramon M. Perez Debra & Robert Peterson Mr. & Mrs. Robert Petkus Pfizer Foundation Inc. Phoebe and John D. Lewis Foundation Mr. & Mrs. Gregory P. L. Pierce Mr. & Mrs. Gordon Lee Pollock Polo Ralph Lauren Ms. Kira Aberle Price The Pritzker Traubert Family Foundation Procter and Gamble Company Mr. Robert Randolph Jr. Ms. Barbara Rapp Mr. & Mrs. Lucius E. Reese Mr. & Mrs. Michael J. Revord Rockford Marlins Swim Club Ms. Mary Bergonia & Mr. Tom Ross Ms. Wendy Chronister & Mr. Peter N. Rogers David L. Saloom Mrs. Elinor Salvino Mr. Scott Sauer Ms. Nicole C. Schachner Mr. & Mrs. James Schink Mr. & Mrs. Frank Edward Schmitz Mr. Michael C. Schnur Mr. & Mrs. Richard P. Scully Mr. Larry J. Schwartz Ms. Ilene Warshawsky Shaw Ms. Jean E. Sheridan Mr. & Mrs. Paul B. Shukis Mr. & Mrs. John Silverman Mr. & Mrs. Frank M. Sims Mr. & Mrs. Gerald D. Skoning Sotheby’s Ms. Donna Speigel Mr. & Mrs. George Spencer Stebgo Metals Inc. Ms. Marilyn K. Straus Mr. Langdon D. Neal & Ms. Jeanette Sublett Mr. & Mrs. Timothy P. Sullivan Ms. Marjorie Tardiff Ms. Penny Pritzker & Mr. Bryan Traubert The Thomas and Jerrice Fritzlen Family Charitable Foundation Mr. & Mrs. J. Mikesell Thomas Mr. & Mrs. Justin Ullman Union College University of Chicago Swimming and Diving Team University of Pennsylvania Van Cleff and Arpels, Inc. Verdura/E.J. Landrigan Inc. Mr. John Harrigan & Mrs. Mimi Mullin Villaume D. A. Voyce Ms. Elizabeth R. Foster & Mr. Michael P. Walsh Mr. & Mrs. Keith Ward Mr. & Mrs. William S. Wardrop Jr. Mr. & Mrs. Marcus D. Wedner Mr. Ray R. Welch Dr. Bryan R. Mitchell* & Ms. Mary T. Uckerman Mr. Gary A. Verhoeven & Ms. Alice Williams-Verhoeven Wittenberg University Ms. Ann Wolff Ms. Leslie A. Yendro Mr. & Mrs. Paul Michael Zelisko Benefactors Under $1,000 122 St. Philip The Apostle 2008 New Trier Girls Water Polo Mr. Joel Aarons Mr. & Mrs. Robert D. Aby Ms. Lisa Ackerman Ms. Eppy K. Adami-Bunyard Mr. Paul R. Adams III Adams Magnetic Products Mr. Jack Adams Ms. Julie Adams Mr. & Mrs. Steven A. Adelman Ms. Yolanda Torrisi Adler Agape Foundation Ms. Holly I. Ahern Mr. Marius G. Aleksa Mr. John Alemanni Mr. James Edward Alexander Ms. Katherine A. Alexander Ms. Alexandra Alexiadis All States Transport, Inc. Allegheny College Mr. Charles Allen Mr. & Mrs. Ronald J. Allen Allstate Investments Ms. Shatha Khalid Almutawa Mr. & Mrs. Ronald S. Alpern Mr. & Mrs. James M. Amend Amherst College Mr. James R. Anderson Mr. & Mrs. Ian Gordon Anderson Mr. & Mrs. David L. Anderson Ms. Nancy E. Anderson Ms. Mary Lind Andresen Ms. Megan Andrew Mr. Arifin Angriawan Anonymous (4x) Ms. D. B. Archambault Ms. Donna R. Holt & Mr. James S. Archibald Mr. & Mrs. Thomas F. Army Donations Support: Kenneth Cohen, MD, and his research to identify new cancer therapies for lymphoma and multiple myeloma. Carola A. S. Arndt Mr. Robert C. Arzbaecher Mr. & Mrs. Charles J. Aschauer Jr. Ms. Dorothy Ascher Mr. Duncan B. Ashurst Mr. & Mrs. Rick Aspan Aurora Township Republican Central Committee Mr. & Mrs. William A. Avallone Mr. Mark A. Awbrey Mr. Terence Bachor Ms. Betty J. Bade Ms. Jennifer Baird Ms. Joyce S. Bakrins Baldwin-Wallace College Mr. John F. Ball Mr. & Mrs. Jon A. Ballis Ms. Janet W. Bambach Ms. Deborah C. Banahan Ms. Adrienne M. Banas Mr. & Mrs. David K. Barclay Mr. & Mrs. Douglas Craig Barnard Ms. Janet Barnat Ms. Rosemary Baron Mr. Eric Barr Ms. Elaine M. Barrett Ms. Kathy J. Barry Mr. Rodney A. Bascom Ms. Judy Bashkin Mr. & Mrs. Jeremy M. Baskin Ms. Linda Basnik Mr. & Mrs. Richard L. Baumgarten Baxter International Foundation Ms. Lynn E. Bazzel Ms. Jennifer J. Beacom Ms. Susan A. Beaumaster Mr. David Beemer Mr. William Beiriger & Mrs. Kathleen Beiriger Mr. Charles J. Bellock Ms. Crystal Benbow Ms. Ricki S. Bennett Ms. Shirley O. Bennett* Ms. Heide Bentley Mr. & Mrs. Robert G. Beran Sr. Ms. Sandra J. Berg Mrs. Edwin A. Bergman Mr. & Mrs. Arthur L. Berman Mr. & Mrs. Larry W. Bernard Mr. Barry Bernfeld Ms. Jennie Bernstein Mr. & Mrs. Z. Samuel Bernstein Best Transportation Services Inc. Ms. Bessie C. Betzelos Mr. Peter E. Beugg Mr. Victor G. Bianchi Ms. Eleanor R. Bick Mr. & Mrs. Richard A. Bieth Biff Ruttenberg Foundation Mr. James Bilsky Mr. & Mrs. C. Edward Bjorncrantz Mrs. Raye Black Ms. Rosemarie A. Black Ms. Sara Blaser Ms. Audrey Bledsoe Rebecca, Sophie & Izzy Bleier Ms. Abigail Bliss Ms. Jennifer B. Blomme Mr. & Mrs. Norman R. Bobins Chris & Natalie Boden Sherrill L. Bodine Mr. Julius Bokodi Ms. Kathleen M. Bokor Ms. Ann L. Boldt Ms. Janet B. Bolonik Beth A. Boman Mr. & Mrs. Scott Bondurant Mr. Darcy Bonner Mr. & Mrs. Daniel J. Boote Ms. Bobbi Borbas Ms. Suzanne Boren Ms. Francine Boudewijn Mr. Richard A. Boudreau Mr. & Mrs. Louis P. Bournakis Boy Scout Troop 56— Burr Ridge, IL Mr. & Mrs. Charles R. Boyd Mr. & Mrs. Christopher Boyd Ms. Lisa A. Boyd Mr. Bruce C. Boynick Ms. Judith A. Bradeen Ms. Brooke Brady Mr. Daniel P. Brady Mr. & Mrs. Russell Brandstetter Mr. & Mrs. Thomas E. Breitenstein Ms. Nancy L. Breitweiser Mr. Garrett T. Brennan Ms. Iretta Brennan Mr. Eric A. Brenner Ms. Gail K. Brenner Briarwood Country Club Mr. Richard A. Broeren *Deceased UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 31 2009–2010 Honor Roll of Donors Donations Support: Tara Henderson, MD, who specializes in the diagnosis and treatment of pediatric cancer—especially second cancers in childhood cancer survivors. Mr. Jeff Bromberek Ms. Anita J. Krichmar & Mr. Sam W. Brooks Ms. Barb Brown Ms. Karin L. Brown Kevin & Kristi Brown Ms. Kristine Larson Brown Mr. Martin Brown Ms. Myra J. Brown Browning Transcript Inc. Mr. Boyd B. Buck John & Kathleen Buck Mr. John A. Buck III & Ms. Carrie P. Buck Ms. Susan S. Buckwalter Ms. Mary Budreck Ms. Kay Bullard Ms. Bayla Bulwa Ms. Vickey Bunker Mr. Daniel A. Bunnell Ms. Betty R. Burfeind Mr. Robert M. Burke Mr. Rafe A. Burnstein Mr. Harold W. Burton Ms. Alicia Marie Bushman Mr. & Mrs. James Bushnell Ms. Erin Butler Ms. Anne M. Byerwalter Ms. Cindy J. Byington Mr. James R. Byrnes Ms. Karen L. Cacciatore Mr. Nicholas W. Cade Mr. & Mrs. Stephen H. Cade Mr. & Mrs. William F. Cahill Mr.and Mrs. G. J. Caldwell Mr. & Mrs. Charles Calhoun Ms. Erin Callahan Ms. Joanne E. Callahan Mr. & Mrs. Michael F. Callero Ms. Patsy A. Campbell Ms. Laura A. Canavesi Mr. & Mrs. Michael Canmann Mr. John Cardone Ms. Lois Carelli Mr. Peter S. Carideo Ms. Lucy Carioscio Mr. & Mrs. Christopher L. Carlee Ms. Celeste Carlin 32 Mr. & Mrs. Richard L. Carlson Ms. Connie T. Carmack Carnegie-Mellon University Julianne Carrara, DMD, MS Mr. Peter E. Carter Carthage College Ms. Laura Cason Mr. Michael R. Cason Mr. Dan Casper Ms. Peggy Cassen Mr. Michael Castleforte Mr. Edward Cedano Ms. Clare E. Cermak Ms. Helen Cernok Ms. Laurie H. Chambers Mr. & Mrs. Philip A. Champeau Mr. & Mrs. Christopher C. Chan Ms. Melissa Chapa Mr. & Mrs. Robert R. Chapin Mr. Carter Chapman Ms. Lorry Charak Mr. Mark Charnot Ms. Jennifer P. Chastain Ms. Grace L. Chen-McClone Mr. & Mrs. James Alan Cherney Ms. Caryn K. Cherpak Chevron Humankind The Chicago Community Foundation Chicago Title Insurance Company Mr. Ying-Kit Choi Ms. Basia Cholewa Mr. Keith J. Christensen Mr. & Mrs. Nick Christopoulos Ms. Konstantina Christopoulos Citigroup Global Markets Inc. Clark University Ms. Ann L. Clark Ms. Anne Clark Ms. Lindsay Clark Mr. & Mrs. William J. Clark Mr. & Mrs. H. Glenister Clarke III Ms. Laura Clements Mr. & Mrs. Everett L. Cline Ms. Kimberly Coady Cogan and McNabola, P.C. Ms. Arlyne D. Cohan Mr. & Mrs. Bruce Cohen Merle & Seymour A. Cohen Mr. & Mrs. Irwin Cohn Ms. Amber Coisman Mrs. Elaine Stone Colburn Mr. & Mrs. Bradford James Colby Dr. Geraldine Balut Coleman Ms. Suzanne Navabpour Coleman College of Our Lady of the Elms Ms. Heather M. Collins Colorado College Mr. & Mrs. Kevin E. Condron Mr. & Mrs. Jeffrey C. Conklin Ms. Christine Conlan Ms. Dana S. Connell Mr. Keith Converse Ms. Ellen V. Cook Mr. & Mrs. Christian Cooley Ms. Brenda K. Cormier Mr. Peter J. Cormier Ms. Aileen Hirsch Cornbleet Ms. Araceli Corona Mr. Andrew Costas Mr. & Mrs. Jay Costley Mr. & Mrs. Andy Courtad Cowtan and Tout CR Grinding, Inc. Mr. John Craig Ms. Corlita R. Cramer Ms. Harriet L. Craven Ms. Kathryn M. Cregan Ms. Chrisitina Crist Mr. & Mrs. Jefferson Crist Ms. Mary Crocker Mr. & Mrs. J. Michael Crouch Crump Insurance Services, Inc. Mr. Nathaniel Crump Mr. Brandon Cruz Crystal Clear MSM Inc. Ms. Judith A. Culkin Ms. Frances Cunnigham Ms. Barbara Flynn Currie Mr. James Cusack Ms. Sue Cybak Mr. & Mrs. Joseph F. Damico Ms. Carol Damron Mr. & Mrs. Thomas P. Danis Dannenberg Meyer Foundation Mr. & Mrs. Edward J. Danovich Dare To Share Mr. Joseph S. Dauparas Mr. Gary G. Davis Mr. Stuart McCrary & Ms. Nancy Davis Theodore K. Davis & Phyllis W. Davis Ms. Susan D. Davis Mr. & Mrs. Thomas Davis Mr. & Mrs. Tony Davis DC Sales Inc. Mr. Philippe J. Baneux & Ms. Lisa De Azevedo Mr. Steven P. De Spain Mr. & Mrs. Henry C. Deaver Mr. Santolo M. Deblasio Ms. Carolyn J. DeBoer Mr. & Mrs. Dan Deco Mr. Edwin J. Deedrick Jr. M. Lynn Herron Deering Ms. Bettie I. Deetz Ms. Patricia D. Deitrich Mr. Christian Dejong Mr. & Mrs. David Anderson DeLong Ms. Shannon F. Deprofio Mr. & Mrs. David Derkowski Deutsche Bank Americas Foundation Mr. & Mrs. Nick M. DeVito Dharma Driven, Inc. Ms. Guadalupe Di Biaso Mr. & Mrs. Jeffrey Diemand Mr.* & Mrs. John J. Dieterle Ms. Laura Dietzel Ms. Joan C. Dilks Ms. Paula A. Dillon Ms. Amy Ditchman Ms. Margaret S. Donlan Ms. Mary Pat Donnelly Mr. & Mrs. David Donovan Mr. & Mrs. William F. Dooley Ms. Kelly Doran Ms. Pauline Z. Dorr Ms. Jennifer Downey Ms. Molly J. Downhour Mr. Dale C. Doxtater Mr. Darryl Drake Ms. Margaret K. Drake Ms. Phyliss G. Dralle Mr. & Mrs. Leo P. Dressel Ms. Ellen H. Dreyer Mr. Brandon Drezner Ms. Kimberly A. Dsida DST Systems, Inc. Mr. Albert Golembeski Jr. & Ms. Jennifer Duboc Ms. Helene Dubow Mr. George E. Duchossois Dupo Community Unit School District #196 Mr. John E. Dwyer III Mr & Mrs. Kevin Dwyer Mr. James B. Easley Mr. & Mrs. William B. Easley Ms. Jane M. Egan Ms. Susan S. Eggers Mr. & Mrs. Michael D. Egidi Ms. Lynn Eikenbary Mr. & Mrs. Alan B. Erinberg Ms. Debra G. Eisenberg Ms. Holly H. Ellerton Ms. Margaret S. Elliott Ms. Caroline M. Ellis Mr. & Mrs. Raymond Ellitch Mr. & Mrs. Ross D. Emmerman Mr. & Mrs. John W. Empfield Mrs. Alix Engel* Ms. Amy Engerman Mr. Richard England III Mr. & Mrs. Scott M. Engstrom Ms. Ellen Esch Ms. Karen Essi Ms. Lindsay Essi Ms. Missy Bundy & Bruce I. Ettelson Euro-Tech Property Services Inc. Mr. & Mrs. Clinton W. Evans Ms. Emily R. Evren Executive Planning, Inc. Ms. Kimberly A. Fair Fairbanks FAST Masters Ms. Ellen L. Falkof Mr. Thomas V. Faragoi Mr. James Michael Faraone Mr. & Mrs. James E. Farmer Mrs. Breege A. Farrell Ms. Georgia Fassos Mr. & Mrs. Robert S. Feder Ms. Carol J. Culberson & Mr. James Fehling Mr. & Mrs. Fred Feinstein Mr. George S. Feiwell Mr. Scott D. Felix Fenice Corporation Ms. Diane M. Fernandez Ms. Clare Margaret Ferrell Mr. Harve A. Ferrill Ms. Eileen Finnegan Mr. & Mrs. Mark A. Fiore Mrs. Lynne G. Firestone First Delta Group, Inc. Fisher Container Corporation Ms. Mary Fisher Dr. & Mrs. Frank W. Fitch Ms. Katherine G. Fitzenreiter Flame-On Productions Mr. & Mrs. John F. Flanagan Ms. Florence Flanders Mr. & Mrs. Timothy John Flannery Mr. & Mrs. Richard S. Fleisher Mr. & Mrs. William E. Fletcher Ms. Kathie Florsheim Mr. Jude Fogarty Mr. & Mrs. Robert K. Foley Ms. Anna Folmar Ms. Juli Foran Ms. Sara Ford Mr. & Mrs. Robert Forney Mr. Jonathan Forsthoffer Ms. Marilyn L. Fox Mr. Michael E. Fox Dr. & Mrs. Harry A. Fozzard Ms. Carol Frank Mr. James E. Franklin Ms. Rebecca Franson Ms. Herta E. Franz Ms. Jeannine Freeman Ms. Joanne P. Freeman Mr. & Mrs. Louis E. Freidheim Mr. & Mrs. Thomas C. Freyman Ms. Elizabeth Freyon Ms. Sara L. Friedl-Putnam Mr. & Mrs. Howard Friend Ms. Lynn L. Friend Mr. & Mrs. Sidney Frisch Jr. Ms. Dolores J. Fritcher Mr. Ron Fritcher Mr. Keith Fritz Mr. George Fuchs Ms. Christianna W. Fugger Mr. George Fugger Ms. Donna Fulton Ms. Diane L. Furlong Ms. Beliza Ann G. Furman Dr. Kaye Gable-Brassfield Ms. Cynthia M. Gabuzzi Ms. Lynn L. Gagne Mr. Peter Gaido Ms. Karen H. Gaines Mr. & Mrs. Van A. Gallios Mrs. Mary K. Gallmeier Ms. Myra Gammon Mr. & Mrs. Wilbur H. Gantz Mr. & Mrs. James L. Garard III Mr. Johnny Garcia Ms. Eileen Garrity Mr. & Mrs. Ben Gatch Jr. Ms. Adrien Gatesman Mr. & Mrs. David R. Gaudet Mr. & Mrs. John F. Gearhart Ms. Maggie Gelber George and Amanda Hanley Foundation Georgetown University Ms. Susan Smith Geraghty Mr. & Mrs. Philip H. Gerner III Mr. & Mrs. Harold Gershowitz Ms. Kathy E. Gesualdo Mr. & Mrs. David M. Gibbons Mr. Hal Gibson Mr. Bingham R. Gilardi Ms. Joan Gilbert Ms. Kari Gilbert Mr. & Mrs. Laurence M. Gill R. Scott Gill Ms. Maureen A. Gillespie Ms. Agatha Gilmore Girl Scouts of Greater Chgo Troop 50811 Mr. & Mrs. Michael V. Giroux Margaret Seeley McNamara Gladman Ms. Karen Glasgow Mr. & Mrs. Brad Glass Mr. & Mrs. Philip L. Glass Mr. Jody Gleason Glenbrook High School District 225 Glenbrook North High School Boys Swim and Dive Ms. Sarah J. Goetz Mr. & Mrs. Charles S. Gofen Ms. Tammy E. Gold Mr. & Mrs. William S. Goldberg Ms. Hilary Goldin Ms. Jacqueline Goldin Mr. & Mrs. Milton Goldin Mr. & Mrs. Robert Seth Goldin Mr. & Mrs. Dennis K. Goldman Mr. & Mrs. Peter D. Goldman Ms. Cheryl Goldstein Mr. & Mrs. Les Goldstein Ms. Anne Livingston Golembeski Ms. Kari R. Gomez Ms. Sharon Goodman Mr. Alan R. Goodyear Mr. Christopher Gordon Mr. & Mrs. Mark Gordon Gorman Foundation Mr. & Mrs. Stephen E. Gormley Mr. & Mrs. Ronald Gorniak Ms. Shelley C. Gorson Gorter Family Foundation Gottlieb Memorial Hospital Medical Staff Ms. Anjali Gottreich Gower District 62 PTO Gower School District #62 Ms. Cheryl R. Grabell Ms. Carrie Grant Mr. & Mrs. Donald Grauer Mr. & Mrs. Paul E. Gray Mr. Steve Greanias Great West Casualty Company Dr. Geoffrey L. & Dr. Marianne E. Greene Mr. & Mrs. Ronald Greenspon Ms. Danielle Greenwood Mr. William E. Greffin Mr. Edward A. Gregory Mr. & Mrs. William Grieve Ms. Sue Grimes Mr. Greogory M. Grodecki Ms. Mary Lewis D. Grow Mr. Roy Grow Mr. Matthew Grubb Mr. Michael Gruener Ms. Elaine Gryn Ms. Sharon Wong Guifarelli Gulfstream Shores Owners Association Mr. & Mrs. Laurence I. Guthmann Ms. Nancy M. Guynn Mr. Alfredo Guzman Ms. Kathleen M. Haan Mr. & Mrs. Charles L. Hackley Ms. Karen M. Hagberg Ms. Linda K. Hagemann Mr. & Mrs. Guy E. Hagen Ms. Karen M. Alberts Haggerty Ms. Susan G. Haitz Danni Halik Ms. Barb Hall Ms. Linda L. Hall Mr. John W. Hallman Mr. Michael D. Halverson Mr. & Mrs. Robert A. Hamer Ms. Maureen J. Hamilton Ms. Angela Joan Hammond Ms. Ester Hana Mr. & Mrs. George Hanley Ms. Jennifer Hanna Ms. Judith F. Hanrahan Ms. Nancy L. Hanson Mr. & Mrs. Frank R. Harder Mr. Thomas Harmon Mr. & Mrs. James C. Harrington Mr. Robert Chapman Harrington Ms. Catharine Jean Harris Mr. David S. Harris Mrs. Sheldon Harris Harry F. and Elaine Chaddick Foundation, Inc./Mr. & Mrs. Christopher C. Craven Ms. Susan Hartemayer Mrs. Rivian Hartman Dr. Michelle Le Beau & Dr. Robert Harwood Donations Support: Population science at the Center for Cancer Epidemiology and Prevention which is identifying molecular, environmental, and genetic susceptibility factors in cancer. *Deceased UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 33 2009–2010 Honor Roll of Donors Mr. David E. Hauck Haven Youth and Family Services Ms. Margaret Hawkins Hawks Soccer Club Mr. & Mrs. Jeffrey L. Hawthorne Mr. Alexander K. Hayden Mr. Thomas H. Hayden Ms. Lynn M. Hayes Ms. Nancy A. Hayes Mr. Wallace M. Hayward Ms. Kathryn C. Healy Ms. Hannah Heavenrich Mr. Richard M. Heavenrich Ms. Elizabeth A. Hebert Mr. Michael Hecht Mr. & Mrs. James Heffernan Ms. Marlene Hefter Mr. Christopher K. Hehmeyer Mr. & Mrs. Steve T. Helms Mr. Steven Robert Goldman & Ms. Lesli K. Henderson Ms. Nancy Henderson Mr. Peter C. Hendrick Mr. James A. Henke Ms. Renee B. Henke Ms. Lorne M. Henne Herbst Family Foundation/ Dr. & Mrs. Arthur L. Herbst Mr. Robert R. Herick Ms. Katrina S. Herman Ms. Mary Hermann Mr. & Mrs. Gerald Hermanson Mr. Robert Hest Ms. Doris V. Hewitt Ms. Patricia Hewitt Ms. Kathleen G. Heylin Ms. Merle B. Heytow Ms. Ann Highum Hill Murray High School Ms. Kathryn W. Hill Ms. Shirley A. Hill Ms. Megan Hinchcliff Mr. Warren K. Hinsch Mr. James J. Hipp Ms. Carol J. Hirman Mr. & Mrs. David F. Hoff Mr. & Mrs. Robert Hoff Ms. Marilyn J. Hoffer Mr. Kevin Hoffmeyer Ms. Susan M. Hogan Mr. William V. Hogan Ms. Claire Holland Mr. Kurtis Holle Ms. Leslie W. Holling 34 Mr. & Mrs. Kevin Robert Holme Mr. Thomas Holmes Ms. Tamara Honza Mr. & Mrs. William L. Hood Mr. & Mrs. D. Hoppensteadt Ms. Carol Horschke Mr. Jerry A. Hortsch Ms. Ileene Horwitz Ms. Peggy Jo Hoskin Hospira Employee Giving Campaign Friends of the Hospital HotWatt, Inc. Mr. & Mrs. Matthew T. Howard Mr. William Howes Ms. Cheryl P. Hudson Mr. Andrew Hughes Ms. Michelle Hughes Li Fang Hung Ms. Holly Hunt Ms. Cynthia M. Hurd Ms. Judith A. Hushaw Ms. Tanya Hussey Ms. LauraJane Hyde Hyslop Shannon Foundation Mr. Ralph J. Iacono Mr. & Mrs. John E. Iannantuoni Mr. Lance A. Ihinger Ms. Katie Ilg IMS Marketing Sevices Ms. Lynn S. Ingvalson Ms. Barbara J. Irwin Mr. & Mrs. Glenn Irwin Mr. Richard Isenberg Ms. Marlene Baron Iser Mr. Salvatore Iuliano Ms. Lynn A. Jachec Jerry A. Jakimsen, MD Mr. Donald J. Jakob Mr. Michael Jakubowski Ms. Candace C. James Mr. & Mrs. C. H. James Ms. Natalie J. Jamrog Mr. Branko Jasnic Mr. & Mrs. Kenneth W. Jautz Ms. Sara J. Jeude Jewish Community Foundation of the Milwaukee Jewish Federation Jewish Federation of Metropolitan Chicago Ms. Angell Jiang Joel Kennedy Constructing Corporation John and Jacolyn Bucksbaum Charitable Fund Mr. Timothy Johns Ms. Terri A. Brady & Mr. David W. Johnson Mr. & Mrs. Joseph Johnson Mr. Jeffrey A. Johnson Ms. Kathryn G. Johnson Mr. Brian E. Jones Mr. & Mrs. John E. Jones Ms. Arlene H. Joniak Ms. Candi Joniak Mr. Jeff Joniak Ms. Tracey A. Jordan Ms. Laura Jost The Josten’s Foundation, Inc. Ms. Theresa C. Jovanovic Ms. Cynthia S. Juby Mr. Wade W. Judge & Ms. Nancy Dusseault Judge Mr. Harold D. Justice Ms. Eleanor Kaden Ms. Betty Kahnweiler Mr. & Mrs. George M. Kaiser Ms. Cara Kalnow Ms. Marci Kaminsky Mamoru Kanazawa Ms. Barbara Kane Mr. & Mrs. Paul Karabinos Mr. & Mrs. John Karamichos Mr. & Mrs. Steve Karson Dr. & Mrs. Robert Katz Ms. Helena I. Kaufman Ms. Cara Kaufmann Ms. Anne S. Kavooras Keay and Costello, P.C. Ms. Nancy F. Keay Mr. & Mrs. Brian Keenan Mr. & Mrs. James E. Keenan Mr. Michael E. Kehoe Mr. & Mrs. Eric A. Keipper Ms. Courtney Kellogg Ms. Kathleen Kelly Ms. Maureen Kelly Ms. Wendy A. Kelly Kemper Educational and Charitable Fund Ms. Jodi Kennedy Ms. Tara S. Kent Ms. Louise P. Kepner Ms. Kari L. Kerrigan Mr. & Mrs. Barry Charles Kessler Mr. Barry Ketchmark Ms. Caroline Khadder Ms. Teja Kics E. Kiefer Mr. & Mrs. Ian Kieninger Kies Consulting LLC Mr. & Mrs. William S. Kies Jr. Ms. Marjorie E. Killeen Mr. & Mrs. Donald A. King Jr. Mr. Matthew Alan Kinney Ms. Nancy J. Kinney Mr. Judson Kinnucan Mr. & Mrs. Barry E. Kipnis Ms. Kim M. Klawitter Ms. Mary Jean Knapp Ms. Susan Knapp Ms. Sandy Knepper Kyle L. Koehn Mr. & Mrs. Robert D. Kolar Mr. & Mrs. Theodore S. Kolontouros Ms. Kari A. Kolsrud Mr. & Mrs. Bernard J. Kompare Mr. & Mrs. James D. Koolish Mr. Thomas J. Koplos Mr. & Mrs. James J. Kosinski Mr. Vassilios A. Kosmas Mr. Andrew Krauss & Ms. Amy Herron Mr. & Mrs. Michael D. Kravets Ms. Fern Kravets Ms. Mary G. Krey & Mr. Brad R. Krey Dr. & Ms. Norton Kristy Kroeger Charitable Foundation Mr. & Mrs. Robert E. Kroll Ms. Diane D. Krueger Mr. & Mrs. Larry Krueger Ms. Susan Boyd Kruesi Ms. Judith Krugman Mr. & Mrs. Mark Krumtinger Krusinski Construction Company Ms. April M. Krydynski Mr. Ravindra Kumar Mr. Sydney Kuramoto Mr. Lawrence E. Kurka Ms. Cyril Kurtz Mr. & Mrs. Steven J. Kuster L. Neill Cartage Co., Inc. L-Kopia, Inc. Mr. William Horton Kurtis & Ms. Donna La Pietra Mr. & Mrs. Edward J. Ladewski Ms. Laura Ladewski Ms. Michelle LaGoia-Schmitt Lake Forest High School Lake Forest Swim Club Ms. Natalie S. Lamb Ms. Jane B. Lambesis Ms. Debra Lamoureux Mr. & Mrs. Lester Lampert Mr. Steven Landry Mr. Lance Lane Mr. & Mrs. Alan Langerud Mx. Penfield S. Lanphier Mr. Robert C. Lanphier Mr. & Mrs. Joseph G. Lansing Ms. Kitty Lansing & Mr. Robert E. Lansing Mr. & Mrs. Alvin Lapper Ms. Sharon A. Larason Mr. & Mrs. Daniel E. Larkin Ms. Laura LaRosa Ms. Lisa Larsen Ms. Elizabeth S. Larson Mr. & Mrs. David J. LaRue Mr. & Mrs. Richard A. Lascola Ms. Ann Latz Mr. Richard E. Lawrence Ms. Rita Moran Laxner Mr. & Mrs. Alan A. Lazzara Mr. Carl Rogers & Ms. Yvette M. Le Grand Mr. & Mrs. William S. Leavitt Ms. Lee A. Lechowicz Ms. Barbara S. Leder Ms. Susan M. Lee Mr. Scott Lennox Mr. Carl N. Lepke Ms. Florence Leroy-Tallent Mr. John Lessick Ms. Lena Leverenz Mr. Bradley B. Levin Mr. Barry Levy Mrs. Janet G. Lewis Mr. & Mrs. Murray J. Lewison Mr. & Mrs. Thomas M. Lillard III Lincolnwood Suites Condominium Association Ms. Kathleen S. Lindsay Mr. & Mrs. Gerald G. Linnert Lipman Hearne, Inc. Mr. David R. Kentoff & Mrs. Susan Lipp-Kentoff Mr. & Mrs. Andrew E. Lippmann Mr. Thomas Lithgow Ms. Courtney Little Ms. Nancy Little Mr. Berle Littmann Mr. & Mrs. Chester A. Lizak Mr. & Mrs. John W. Loeb Ms. Melissa Beth Loeb Mr. & Mrs. Wayne K. Loek Mr. Michael Logan Mr. & Mrs. Patrick W. Logan Ms. Regina Lopata Logan Ms. Ann Lombardi Mr. & Mrs. Daniel Long Ms. Caroline V. Longshore Mr. & Mrs. J. Alberto Lopez Mr. Michael M. Lopez Ms. Edith T. Lopez-Valdes Mr. Dale C. Lorens Mr. & Mrs. P. J. Loughran Ms. Nancy Lowenthal Ms. Mary Lucca Mr. Paul Lunderby Ms. Gina Luordo Ms. Karen L. Lusson Mr. Joshua C. Luttig Ms. Carole Kay Lynn Ms. Karen Mabie MacAlester College Ms. Marti DeGraaf & Mr. Toby Mack Ms. Karen Mackay Mr. & Mrs. Richard J. Mackey Jr. Mackinac Island Yacht Club Ms. Maggie Madole Ms. Constance F. Magnuson Mr. Judd D. Malkin Mr. Stephen J. Malkin Ms. Ellen D. Malone Ms. Julie Ann Mangan Ms. Kathleen Manilla Ms. Kara Mann Mr. & Mrs. Daniel J. Marchuk Ms. Denise Marconi Ms. Jamie Marek Ms. Lynne A. Marek Ms. Sarah Marinacci Mr. Peter G. Maris Mr. Martin J. Markert* Ms. Shanna Marie Marrazzo Ms. Mary L. Marshall Ms. Elizabeth J. Martin Mr. Matthew Martin Ms. Nan L. Martin Mr. Jeffrey J. Martindale Ms. Mary C. Martindale Ms. Amy Martinez Mr. & Mrs. Ronald A. Marwitz Ms. Marla Massel Ms. Shirley A. Massel Ms. Eileen M. Massimilian Masterplan, Inc. Ms. Ann E. Mathis Ms. Beverly A. Matre Mr. Gregory Mattingly Ms. Jennifer Maxcy Mr. & Mrs. Isaac Mayefsky Mr. & Mrs. Alan H. Mayer Mr. Mark E. Mcananey Mr. Kevin J. McCarthy Ms. Judith McCormick Mr. Kevin C. McCune Ms. Debbie A. McCurrie McDaniel College Ms. Linda Mcdermott Mr. Sean T. McDermott Ms. Beryl McDonough Donations Support: Donald J. Vander Griend, PhD, and his work to identify new therapies for prostate cancer. Ms. Laurie M. McElligot Mr. & Mrs. Roger S. McEniry Mr. & Mrs. Steven D. McGhee Mr. Mark A. Sagin & Ms. Bernadette M. McGoldrick Mr. & Mrs. Lawrence J. McGrath Ms. Maureen T. McGrath Ms. Thomas McGrath Mr. & Mrs. Timothy R. McGugan Ms. Margaret S. McInerney Ms. Karen McIntosh Ms. Joyce A. McKnight Ms. Susan J. McKnight Ms. Patricia O. McLaughlin Ms. Leslie B. McLean Ms. Norah M. McMorrow Ms. Gina D. McNamara Ms. Jennifer A. McNerney Mr. & Mrs. Peter McNitt Mr. & Mrs. Corey B. McPherrin Mr. & Mrs. Matthew G. McQueen Mr. & Mrs. Mark S. Medland Mr. David Meers Ms. Misra Meghna Ms. Roberta A. Mego Ms. Emily Meier Ms. Helen H. Melchior Mr. & Mrs. Michael H. Meltzer Dr. Umberto Tachinardi & Dr. Eneida Mendonca Ms. Barbara B. Meyer Mr. & Mrs. Bernard Meyer Mr. & Mrs. Jerome Meyer Mr. & Mrs. Eric Meyer Ms. Ashley Meyers Mr. Robert J. Michalak Mr. David B. Michels Ms. Brenda Lee Michuda Mr. Mark Michuda Middlebury Aquatic Club Middlebury College Swim Team Midwest Warehouse and Distribution System Inc. Ms. Constance W. Miller Ms. Ellen M. Mills Ms. Jeriza Mills Mr. Anthony M. Millspaugh Mr. & Mrs. Jim M. Minchella Mr. & Mrs. Paul Minkus Mr. Michael J. Mitchell Mr. Todd Mitchell Ms. Mary E. Moen Ms. Angela Molloy Mr. Roger G. Molski Mr. & Mrs. Jeffrey Monger Mr. & Mrs. Joseph Moore Ms. Jean Moorhead Mr. Steven J. Moran Morgan Administration Inc. Mr. James A. Morman Ms. Carolyn Mottley Ms. Anne S. Mueller Ms. Kai H. Mulford Muller and Monroe Asset Management LLC Mr. George E. Muller Mr. Joseph P. Mulligan Ms. Catherine C. Mullin Mr. John Fedele & Ms. Elizabeth Mullin Mr. Evan Mullin Ms. Margaret L. Mullin Murphy Jahn Architects Ms. Erin Murphy Ms. Laura K. Murphy Ms. Melissa Murrell Mr. Daniel M. Gill & Ms. Debra L. Myers Ms. Enid M. Myers Ms. Cynthia B. Nack Ms. Jody Naeher Ms. Nancy Nagel Mr. Ralph Nappi Ms. Amy Weiss Narea NASA/Wildcat Booster Club Ms. Sherry L. Nash R. Wendel Naumann Nazareth College, Department of Athletics Ms. Mackinzie Neal Mr. Robert J. Nearpass Ms. Jean C. Neill Ms. Joan F. Neill Mr. & Mrs. Robert R. Neill Ms. Ramona J. Nelson Mr. & Mrs. Brad H. Neuman Dr. Laura & Dr. Charles Neumann Mr. & Mrs. Tom Neuville Mr. & Mrs. John Newark Ms. Diane B. Newman Mr. & Mrs. Gordon H. Newman Ms. Diana Nguyen Ms. Margaret S. Nichols *Deceased UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 35 2009–2010 Honor Roll of Donors Ms. Marie N. Nichols Ms. Nita Nickow Ms. Shirlee Nickow Mr. & Mrs. Frederick B. Nicolai Mr. & Mrs. Greg Nicoll Ms. Therese A. Niedzielski Mr. Ronald V. Niehaus Mr. & Mrs. Kenneth B. Nilsen Mr. & Mrs. Carl G. Noeller Ms. Marilyn T. Nolan Mr. & Mrs.Thomas P. Noonan Ms. Ann Noone Dr. & Mrs. Gary L. Nordbrock Norehad Charitable Trust Mr. & Mrs. Steve Norehad Northshore Swim Science LLC Mr. & Mrs. Timothy J. Notaro J. Nouota Mr. Brian Novak Ms. Erin Nowakowski Ms. Robin C. Nuzzo Mr. Phillip O’Brien Ms. Tracey K. O’Donnell Ms. Jill F. Odzer Mr. & Mrs. Joseph Olack Ms. Katherine A. Olack Ms. Irene D. Oleary Ms. Sara Olesker Ms. Charlene H. Olson Mr. & Mrs. Norman Olson Ms. Mary Elizabeth Olson Ms. Marilyn B. Omahen One17, Inc. Mr. & Mrs. Daniel E. O’Neil Ms. Christine Caitlin O’Neill Ms. Jillian O’Neill Mr. Kevin D. O’Neill Mr. & Mrs. Mark P. Onstott Ms. Alice M. Ooms Mr. & Mrs. Thomas G. Opferman Opulent Interiors LLC Mr. Aureliano M. Ordonez Dr. Pierre-Andre Chiappori & Dr. Kristina Orfali Ms. Kelly M. Orland Mr. & Mrs. James G. Orphan Donations Support: Mr. & Mrs. Thomas P. O’Toole Ms. Erin Ott Ms. Marjorie G. Owen Mr. & Mrs. David R. Padgitt Mr. & Mrs. John Pahigianis Ms. Susan Kutchin Pallant Mr. Gerald Palm Ms. Ashley Palmer Ms. Beth S. Palmer Dr. & Mrs. David Joshua Palmer Ms. Heidi L. Palmer Mr. & Mrs. John Palmer Ms. Melinda Palmer Mr. Alan Paluszek Sr. Panik Enterprises, LLC Mr. & Mrs. Paul A. Pankros Mr. Alex Panozzo Mr. & Mrs. Roger Paquin Delfin Paris Park Avenue Consultants, Inc. Chanik Park Mr. Si Hong Park Mr. William B. Parker Mr. & Mrs. Peter Parthenis Mr. & Mrs. Ron Pasowicz Mr. & Mrs. Homi B. Patel Mr. & Mrs. Paul Aaron Patten Ms. Jean F. Patterson Mr. & Mrs. Thomas G. Patterson Mr. Patrick M. Patterson Mr. William T. Patterson Ms. Lona Patzke Mr. & Mrs. Steven E. Paulson Ms. Diane E. Pearsall Mr. & Mrs. Kirby Pearson Mr. Robert T. Pearson Ms. Lisa M. Pease Ms. Laurie C. Pekich Ms. Cecelia Pelc Ms. Catherine E. Penning Mr. & Mrs. Randall W. Perkins Ms. Bridget Perlmutter Ms. Carol Benenson Perloff Mr. & Mrs. David E. Pernell Mr. Bryan Perrott Mr. Gerald E. Perutz Xiaochuan Pan, PhD, who is studying advanced imaging and radiation technologies to increase the effectiveness and reduce the side effects of radiation therapy. 36 Mr. Robert D. Eaton & Ms. Nancy L. Peschel Peter D. and Carol Goldman Foundation Ms. Kay E. Peters Ms. Eva Johnson Petersen Mr. Richard A. Petersen Mr. Andrew J. Peterson Mr. & Mrs. David D. Peterson Jr. Ms. Linda G. Petrasek Dr. & Mrs. David T. Petty Mr. Richard J. Pfleeger Mr. & Mrs. Heber Pierce Mr. & Mrs. John Stephan Pircon Mr. Richard J. Pire Ms. Irma L. Pittroff Mr. & Mrs. John J. Piva Jr. Ms. Jennifer A. Planson Ms. Aimee Platt Ms. Gloria J. Plescher Pliant Corporation Ms. Andrea Poggetto-Drake Ms. Shirley C. Polaski Ms. Lisa Pollard Ms. Amy Lowry Poole Poplar Grove State Bank Ms. Joan M. Porter Dr. & Mrs. Bruce Wayne Porterfield Mr. & Mrs. Norb Poss Ms. Susan Postaer Ms. Barbara F. Potter Mr. & Mrs. Joseph A. Power Jr. Ms. Cathy J. Priess-Perrott Mr. Kenneth J. Printen Mr. & Mrs. Greg Pritchard Ms. Gabrielle H. Pritchett Mr. G. Michael Prugh Mr. Juan Puente Mr. Kevin Putz Ms. L. K. Pyzik Mr. Thomas Quamme Mr. & Mrs. Mark E. Quinnell Mr. Guillame Ragetly Dr. Elizabeth A. Grove & Dr. Clifton W. Ragsdale Mr. & Mrs. Michael J. Rahn Ms. Lisa Ralph Mr. Ganesh G. Raman Ms. Gail E. Rancic Ms. L. A. Rasmussen Mr. & Mrs. James R. Rawls Ms. Kathryn E. Rea Ms. Deirdre D. Redding Ms. Lori A. Redeker Mr. James E. Schwing Mr. & Mrs. Brett Reed Mr. & Mrs. Angelo Ressa Ms. Diane M. Reichlen Ms. Kathleen A. Reid Mr. & Mrs. James W. P. Reid-Anderson Mr. Craig L. Reingold Mr. Robert L. Reiser Ms. Patricia P. Reiss Mr. & Mrs. Steve Renno Mr. Alexander Reo Mr. Bob Reshkin Mr. David Reuland Ms. Maria A. Reyes Mr. & Mrs. Edward T. Reynolds Ms. Mary Reynolds Mr. Robert S. Rhodes Richard Thomas Architects Ms. Anne O. Richardson Ms. Helen L. Richardson Mr. Shelby Richardson Sr. Ms. Dolores M. Richert Mr. & Mrs. Jerome Rieder Ms. Cherelyn Riesmayer Ms. Jean Riley Mr. Frank Rinker Ms. Tanya Ripp Mr. Craig H. Ritter Ms. Nancy P. Ritzi Mr. & Mrs. Thomas Rivi Ms. Megan Robb Mrs. Rebecca E. Crown & Mr. Richard Hunt Robb Mr. Spencer Robbins The Robert Thomas Bobins Foundation Ms. Pamela Robertson Mr. Andrew R. Robichaud Mr. & Mrs. Stanley R. Rodgers Mr. Kip Rodrigue Mr. & Mrs. Richard Roduner Ms. Delaney Rolfe Mr. & Mrs. Michael Romano III Ms. Peggy J. Romirowsky Ronald J. Romack Golf Shop, Inc. Mr. Pompeani E. Ronald Ms. Carol B. Roper & Mr. Gerald J. Roper Mr. Albert Rose Ms. Judith S. Rosen Ms. Janice M. Rosenburg Mr. Lee A. Rosenthal Mr. & Mrs. Warner A. Rosenthal Mr. George S. Ross Mr. & Mrs. Ralph Ross Mr. John S. Rothschild Mr. & Mrs. Philip R. Rotner Ms. Leigh A. Rubino Mr. & Mrs. Howard Rudolf Mr. Benjamin T. Ruhme Ms. Lori R. Runquist Mr. Kevin M. Rupp Ms. Mary M. Russert Ms. Jean M. Ryan Ms. Sarah Dell Ryan Ms. Jessica Sachs Mr. & Mrs. Jeffrey A. Sacks Ms. Patricia A. Sacony Ms. Lisa Sagami Saint Mary’s University Ms. Sandra Sakun Salisbury State University Mr. Alan N. Salpeter Mr. & Mrs. Vincent J. Salvatore Ms. Ann Kowalsky & Mr. Jerrold E. Salzman Mr. Greg Sams Ms. Regina Sandberg Ms. Susan M. Sanders Mr. & Mrs. Tim Sandow SARCA Ms. Elizabeth K. Saunders Ms. Jessica Savage Ms. Karen H. Scarlett Ms. Linda Schaefer Mr. Shawn Schaffer Mr. Robert P. Schaible Ms. Susan M. Schapp Mr. & Mrs. Gregory A. Schavey Ms. Martha E. Schick Ms. Jean A. Schiller Ms. Karen M. Schillings Ms. Anna Martin Schleusener Mr. & Mrs. Robert Schlossberg Mr. & Mrs. James B. Schlueter Mr. & Mrs. Michael Schneider Mr. Jason Scholl Mr. & Mrs. Robert Alan Schriesheim Ms. Laura L. Schriesheim Ms. Sherry A. Schroeder Mr. & Mrs. Robert A. Schultz Ms. Lisa A. Schumacher Mr. Christopher Schutt Mr. Paul H. Schutt Mr. & Mrs. Richard D. Schwartz Mr. James E. Schwing Mr. James B. Scott Ms. Elise H. Scroggs Mr. & Mrs. Stephen P. Seder Ms. Cassie Seebart Ms. Holly E. Seguine Jun Hang Seol Mr. & Mrs. Dale P. Serani Mr. & Mrs. Laurence Jay Shapiro Ms. Kathleen R. Sharp Shasta Produce Ms. Maureen E. Sheehan Ms. Linda Rae Sher Ms. Muriel Horn Sherman Mr. Robert C. Shermer Shodeen Family Foundation Mr. & Mrs. Lloyd G. Shore Mr. Peter W. Shull Mr. & Mrs. Mark Shure Mr. Gustavo O. Abello & Ms. Isabell Siegel Ms. Barbara Siegel Mr. & Mrs. Jerry G. Silbert Ms. Nancy A. Silva Mr. & Mrs. Gary Silverman Taaron S. Silverstein Simeone Deary Design Group Mr. & Mrs. Howard Simon Mr. & Mrs. Scott Simpson Mr. & Mrs. Brian D. Sims Mr. David C. Sinclair Mr. & Mrs. Thomas John Skelly Mr. & Mrs. Samuel Skinner Mr. & Mrs. Harry Sklare Ms. Katherine SkoffHendrickson Slavin and Slavin Sloan Valve Company Ms. Leona H. Slocum Mr. & Mrs. David S. Sluyter Ms. Darlene L. Smith Mr. & Mrs. Christopher B. Smith Mr. & Mrs. Thomas W. Smith Mr. & Mrs. Gerson Smith Ms. Karen Smith Ms. Maureen Kane Smith Mr. Ralph H. Smith Mr. Sean P. Snee Mr. & Mrs. Stephen L. Snider Ms. Jacqueline S. Snyder Ms. Mignon W. Dupepe & Mr. John B. Snyder Jr. Mr. & Mrs. William R. Snyder Mr. & Mrs. Ronald J. Sobczak Mr. Robert A. Sochowski Jr. Mr. Thomas Sochowski Society of St. Vincent Depaul Soda Moms Water Polo Team Ms. Brenda K. Sollitt Mr. & Mrs. Leonard H. Solomon Mr. & Mrs. George C. Soos Mr. & Mrs. Gregory Lee Sorensen Ms. Lucrecia Soruco Mr. David Souaid Ms. Carole D. Spainhour Ms. Lynn Speaker-Epping Special Care Orthopedics and Hand Surgery Mr. & Mrs. Marc Spellman Ms. Christina Spence Mr. Earl L. Spencer Ms. Joan M. Spilde Mr. & Mrs. Thomas Spitz Mr. Donald Spoelhof Mr. Bruce M. Spoelman Ms. Georgene S. Spoonhour Ms. Kate Spota Mr. & Mrs. John Sprague St. Olaf College St. Thomas University Mr. Michael Staenberg Allison Margolies & David J. Stagman Mr. Mark Stajodhar Ms. Betty Stamatis Mr. Ted T. Stamison Mr. Marcellus Stamps Mr. Phillip Kowalski & Ms. Debra J. Stanek Ms. Ann Marie K. Stanton Ms. Valerie A. Stark Mr. & Mrs. C. Edwin Starr Mr. & Mrs. Joseph Benedict Starshak Ms. Martie A. Staser State University of New York at Cortland Mr. & Mrs. Daniel K. Stecich Ms. Stephanie P. Steenbergen Mr. & Mrs. Richard J. Stefanski Mr. Steven G. Steger Mr. & Mrs. Rob Stein Ms. Jane Stekala Jill Annette Stephenson Mr. Matthew J. Stern Mr. & Mrs. Steven H. Stern Dr. Alan Stewart Ms. Shirley Stewart Mr. William H. Stimpson Mr. & Mrs. Richard Stoddart Mr. & Mrs. David Stoehr Mr. & Mrs. Paul A. Stokely Mr. & Mrs. Daniel A. Stone Ms. Linda Stone Ms. Susan L. Stone Mr. & Mrs. Peter C. Stott Ms. Jane Strauss Mr. Paul Stroka Ms. Grace W. Strome Sub Source, Inc. Mr. Scott R. Sullivan Summit Partners Mr. Martin Sussman Ms. Michelle Swan Mr. & Mrs. Robert B. Swanson Ms. Leslie R. Swenson Dr. & Mrs. Henry S. Swiontek Ms. Dolores M. Szafranski Ms. Judy Szezepaniak Ms. Jenna Szkatulski Ms. Dorinne Taback* Mr. Edward D. Taback Ms. Teri N. Takehiro Ms. Virginia S. Tarika Ms. Anne Taubeneck Ms. Michelle Taubman Ms. Donna M. Tauchen Ms. Kathleen Marie Taylor Ms. Marlene M. Taylor Ms. Tracy Taylor Mr. Rick Tears Mr. Jason E. Techmer Mr. & Mrs. Jeffrey Teichner Mr. & Mrs. Earl H. Temkin Mr. Michael H. Tempest Aimee LaPointe Terosky The College of Wooster Mr. John W. Thoman Jr. Mr. Lowell M. Thomas Mr. Richard Thomas Ms. Jill H. Thomson Mr. & Mrs. Robert Thorsen Mr. & Mrs. Albert H. Tippens Jr. Ms. Dawn Torii Mr. & Mrs. John K. Totten Ms. Sandee A. Tourville Ms. June Felicia Bennett & Dr. V. Leo Towle Mr. & Mrs. William H. Towle Mr. & Mrs. Bernard Townsend Ms. Alice C. Tracy Mr. & Mrs. Jamie M. Trapp Ms. Julie Traub Ms. Susan N. Travetto Ms. Christine L. Tribble Ms. Janice C. Trilla Ms. Donna Triolo Mr. & Mrs. Thomas P. Troll Ms. Cindy Truckenbrodt Truist Ms. Nancy A. Tsivitse Ms. Barbara M. Tubekis Tufts University Mr. & Mrs. Lester Tukan Ms. Donna M. Tuke Mr. & Mrs. Howard A. Tullman Mr. & Mrs. Thomas N. Tunnicliff Ms. Kathryn Claire Turner Mr. & Mrs. Timothy H. Ubben Ms. Frani Udell Unattributed Memorial Gifts Mr. Douglas A. Unger Unique Appeals Ltd. University of Le Verne Swimming and Diving Mr. & Mrs. Steven D. Urban Vagus Inc. Mr. Christopher Vaky Mr. Thais Valenca *Deceased UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 37 2009–2010 Honor Roll of Donors Ms. Betty J. Valentino Mr. Jeffrey C. Van Troba Mr. & Mrs. Laurent Vanneste Ms. Bonnie Wolf Vasilion F. Ventrella Mr. Willie Vernic Doerr Mr. Randolph K. Vest Ms. Aimee C. Villard Mr. Edward F. Villaume Villianova University Swimming Mr. James Voelschow Ms. Kelli L. Vogel Barbara H. Volk MD Mr. & Mrs. Robert Von Halle Mr. & Mrs. H. Kurt von Moltke Ms. Jean Vondriska Ms. Nancy E. Voss W-W Public Relations, Inc. W. F. Foundation Ms. Jane D. Wagner Ms. Margaret M. Wagner Ms. Suegene A. Wagner Ms. Renee K. Wahl Ms. Joyce E. Wainer Ms. Mary Pat Wallace Mr. James J. Wallgren Mr. & Mrs. Wally Wallis Ms. Debby R. Walser-Kuntz Ms. Laura D. Walsh Ms. Margaret E. Wampnar Ms. Feena Ward Mr. Ken B. Warren Washington and Lee University Ms. Rosa L. Webb Ms. Cheryl L. Weber Mr. & Mrs. Robert Weber Ms. Kathryn Ryan Weimar Ms. Abby R. Weiner Mr. Jack H. Weiner Weinstein Family Foundation Mr. & Mrs. Robert P. Weinstein Mr. Samuel Weinstein Ms. Cindy Weisling Mr. & Mrs. Donald J. Weiss Ms. Cary Weldy Ms. Whitney Weller Mr. & Mrs. William G. Welnhofer Ms. Lenore J. Welsh Ms. Wende O. Werkmeister Mr. & Mrs. Robert Werner Wessel Family Foundation Mr. & Mrs. Jeffrey H. Wessel West Austin Athletic Club Mr. & Mrs. Mark R. Westhoff Mr. Jeff Wettach Wheaton College Dr. & Mrs. Robert M. Whitcomb Mr. & Mrs. Blair H. White Mr. & Mrs. Kevin P. White Ms. Susan White Mr. & Mrs. William White Mr. Timothy M. White Dr. Jon Braddock Whitehurst & Ms. Marybeth J. Whitehurst Whitman Swimming Ms. Carrie C. Wian Mr. & Mrs. Edward E. Wicks Ms. Andrea E. Widen R. C. Wierman Mr. Dennis P. Wiggins Williams College Swimming and Diving William and Wilma Dooley Foundation Mr. & Mrs. Randall E. Williams Ms. Nancy Rule Williams Mr. & Mrs. Neale A. Williams Ms. Marchell Willian Wilmington College Mr. Neil S. Wilner Ms. Kathleen Goss Wilson Mr. & Mrs. J. Reading Wilson Mr. Peter A. Winograd Ms. Barbara R. Winter Mr. & Mrs. James R. Woldenberg Mr. & Mrs. Jay R. Wolff Mr. & Mrs. Lee Wolfson Mr. & Mrs. Harry S. Wolin Ms. Rita A. Wong Mr. & Mrs. Christopher D. Wood Mr. Bruce R. Woodbury Ms. Marilyn Woodrow Mr. Matthew B. Woodrow Mr. Douglas R. Woodworth Mr. & Mrs. H. R. Workman Mr. & Mrs. Chester Wright Ms. Margaret C. Wunschel YAC Swimming Mr. & Mrs. Mark A. Yeager Ms. Eileen Yedlin Mr. Jerome Yendro Ms. Jacinda Yerga Mr. Kurtis Walsh & Ms. Carolyn Ann Yoch Mr. & Mrs. Charles G. Yorke Mr. Young You Mr. Brian Thomas Young Mr. & Mrs. David Y. Young Mr. & Mrs. Michael Andrew Young Ms. Amy L. Zakiewicz Mr. Zoran Zarkovic K. Zeleny Mr. Bingyue Zheng Mr. Kirby J. Zicafoose Ms. Naomi J. Ziegler Ms. Ronda M. Zielinski Ms. June E. Zimmer Mr. Robert S. Zimmer* Mr. & Mrs. William Zimmerman Ms. Paula Zubrzycki Mr. Peter D. Zuehlke Ms. Shelley E. Zuraw Mr. & Dr. Leon E. Zygmun The UCCCC is enormously grateful for the generous, unwavering commitment of our contributors. Every effort was made to ensure the accuracy of this publication. We would greatly appreciate notification of any errors or omissions in order to correct our records. Please call or write: Marilyn Duran The University of Chicago Cancer Research Foundation 5841 S. Maryland Ave., MC1140 Chicago, IL 60637-1470 Phone: 1-773-702-6566 Fax: 1-773-834-7855 [email protected] *Deceased 38 2009–2010 Financial Report Beginning Balance—$2,990,177 Income UCCRF Contributions $ 640,936 Trustees Capital Campaign $ 479,606 Boards/Auxiliaries $ 1,101,052 Women’s Board Campaign $ 139,687 Endowment Income $ 78,422 Income UCCRF Contributions UCCRF Contributions 26.3% 26.3% $ 2,439,703 Trustees Capital Campaign Trustees Capital Campaign 19.7% 19.7% Expenses Women’s Board Campaign Women’s Board Campaign 5.7% 5.7% Endowment Income Endowment Income 3.2% 3.2% Operating* Personnel $ 293,714 Services $ 366,077 Supplies $ 8,788 $ 668,579 Boards/Auxiliaries Boards/Auxiliaries 45.1% 45.1% Expenses Allocations Research & Faculty Support $ 583,934 Women’s Board $ 610,000 Auxiliary Board $ 117,000 Associates Board $ 25,000 Capital Campaign $ 1,000,000 Allocations Allocations 77.7% 77.7% Operating Operating 22.3% 22.3% $ 2,335,934 Total Expenses/Allocations $ 3,004,513 Ending Balance—$2,425,367 * Period from 7/1/09–6/30/10 UCCCC 2009–2010 Annual Report n cancer.uchicago.edu 39 Pursuing Groundbreaking Research to Deliver Customized Cancer Care This report has described a year of steady progress at the UCCCC—a year distinguished by groundbreaking research that has fueled customized patient care. We have long pursued an approach that encompasses prevention, detection, treatment, community engagement, and survivorship. It is likely that solutions to cancer will come from combinations of these elements. Adding the word “comprehensive” to our name confirms our continued commitment to an all-inclusive strategy for cancer research and cancer care. Our members are at the forefront of a new era of personalized medicine. We look forward to the discoveries of the new year and the promise of tomorrow. 40 Help Advance Research and Cancer Care To make a donation or to learn more about how you can help our researchers explore new ways to treat and ultimately defeat malignant disease, contact The University of Chicago Cancer Research Foundation (UCCRF) Executive Director Mary Ellen Connellan: Online: cancer.uchicago.edu/donations E-mail: [email protected] Phone: 1-773-834-7490 Mail: The University of Chicago Cancer Research Foundation 5841 S. Maryland Ave., MC1140 Chicago, IL 60637 The UCCRF is a not-for-profit 501(c)(3) organization. Federation Tax Identification Number 36-6056201. All gifts are tax deductible as provided by law. The University of Chicago Comprehensive Cancer Center Michelle M. Le Beau, PhD Director, UCCCC; Professor of Medicine; Director, Cancer Cytogenetics Laboratory Marcy A. List, PhD Associate Director for Administration, UCCCC; Scientific Director, Cancer Clinical Trials Office Marsha R. Rosner, PhD Deputy Director for Basic Sciences, UCCCC; Charles B. Huggins Professor and Chair, Ben May Department for Cancer Research Richard L. Schilsky, MD Deputy Director for Clinical Sciences, UCCCC; Professor of Medicine; Section Chief, Hematology/Oncology Habibul Ahsan, MD, MMedSc Associate Director for Population Research, UCCCC; Professor of Health Studies, Medicine, and Human Genetics Geoffrey L. Greene, PhD Associate Director for Basic Sciences and Education, UCCCC; Virginia and D.K. Ludwig Professor and Vice Chair, Ben May Department for Cancer Research; Co-Director, Ludwig Center for Metastasis Research Yves Lussier, MD Associate Director for Biomedical Informatics, UCCCC; Associate Professor of Medicine; Director, Center for Biomedical Informatics Follow us: Mark Ratain, MD Associate Director for Clinical Sciences, UCCCC; Leon O. Jacobson Professor of Medicine; Director, Center for Personalized Therapeutics Groundbreaking Research, Customized Patient Care Executive Editor: Natalie Boden Karen E. Kim, MD, MS Director, UCCCC Office of Community Engagement and Cancer Disparities; Associate Professor of Medicine Contributors: Paul Butera, PhD, Hoyee Leong, PhD, Jayant Pinto, MD, Cassie Simon, CTR Design: Brierton Design UCCCC 2009–2010 Annual Report n (from left) UCCCC Co-Deputy Director Marsha Rosner, PhD, Director Michelle Le Beau, PhD, Co-Deputy Director Richard Schilsky, MD, and Associate Director Marcy List, PhD. James Schilling, PhD Director, Office of Shared Resource Facilities; Associate Director, Core Facilities Natalie Olinger Boden Director, Communications and Public Relations Mary Ellen Connellan, MA Executive Director, The University of Chicago Cancer Research Foundation Hoyee Leong, PhD Director, Scientific Communications and Strategic Partnerships Maria Reyes, MBA Director, Finance Consuelo Skosey, RN, CCRP Director, Clinical Research Operations; Technical Director, Cancer Clinical Trials Office Umberto Tachinardi, MD, MSc Director, Informatics; Associate Professor of Medicine cancer.uchicago.edu ©2010 by The University of Chicago Cancer Comprehensive Cancer Center. All rights reserved. C H CH3O2C H H HO O O OH C3H7 H H OH HO O O O O H CO2CH3