Spring Leaflet, 2012 - Donald Danforth Plant Science Center
Transcription
Spring Leaflet, 2012 - Donald Danforth Plant Science Center
THE Volume 14, Issue 1 Spring 2012 GrowinG nutrient rich Plants in Poor soil How a Grant from the National Science Foundation will Help Center Researchers Develop Corn that Grows Healthy with Less Fertilizer I 5 Mel Bahle Remembered | 3 Beating the Stomach Bug | 4 Robotics Coming to the Center | 7 The Leaflet is a publication for partners, friends, and supporters of the Donald Danforth Plant Science Center. C enter Rememb er s Loyal Friend Melvin C . B ahle D anfor th C enter Rec eiving International Humanit arian Awar d The World Affairs Council of St. Louis is set to present the International Humanitarian of the Year Award, the organization’s top recognition, to the Danforth Plant Science Center on June 7 at the Chase Park Plaza. This award acknowledges individuals or organizations that are based in the St. Louis region and contribute extensively to meeting the humanitarian needs of people around the world. Accepting the honor on behalf of the Center are Chairman Dr. William H. Danforth and President Dr. James C. Carrington. The award is in honor of the Center’s plant science research to feed the hungry and improve human health. The award specifically recognizes its research to improve food production, quality and security with the ultimate goal of reducing world hunger. n To request a copy of the formal invitation, please phone Chandra Thurman at (314)587-1073. N ew B iotech Incubator S et to Augment St . Loui s’ B io s c ienc e Prominenc e The Danforth Center and BRDG Park’s placement at the epicenter of the burgeoning plant and life science ‘node’ in St. Louis County will soon be strengthened further with the opening of the Helix Center Biotech Incubator just west of the Center’s campus this summer. Located at 1100 Corporate Square Drive, the completely renovated, two-story building will offer affordable, high quality wet and dry lab space, offices and a conference center. The all-new 33,000-squarefoot incubator will focus on bioscience, technology and plant and life science startups, as well as professional service firms involved in these sectors. The Helix Center Biotech Incubator is owned and will be operated by the St. Louis County Economic Council. The area around the Danforth Center is quickly becoming an attractive place for a variety of nascent bioscience companies because of the symbiotic relationships and resources that are offered in the vicinity. The Center’s third mission point of making St. Louis a world center for plant science is directly reinforced by the formation of incubators like Helix. Due to its location, not only does the Helix Center have the opportunity for collaborations with the Danforth Center (and potential access to its core facilities), but it is also in close proximity to BRDG Park (home to successful post-incubator and emerging companies), as well as Monsanto’s world headquarters. Helix tenants will also have affordable access to a workforce of skilled bioscience lab technicians through the St. Louis Community College Center for Plant and Life Science, located on the BRDG Park campus. For more information about the Helix Center, visit www.HelixCenter.com 2 n The Danforth Center mourns the loss of a steadfast supporter and Friends Committee member Melvin C. Bahle. A modest, generous man, he was once quoted stating, “People less fortunate than we deserve our help. You have to get involved with other people. It’s the only way to learn, to get new ideas, and to grow. I learn something from everyone I meet.” In addition to having the Center’s business office complex named for him and his wife Sue, the two were also presented with the Distinguished Service Award in 2009. Mel wasn’t just involved the Center, he was a wellknown community and business leader throughout the region. Mel Bahle was born in 1919 in Fremont, Nebraska to Carl and Minnie Bahle. While attending junior college in Grand Island, Nebraska he met his future wife, Sue Sommer, during a churchsponsored ice-skating event, and the two were married on June 16, 1942. Historic international turmoil would keep them apart for the first years of their marriage, with Bahle serving his country in World War II. Bahle began his service in the Nebraska National Guard. After the attack on Pearl Harbor he opted to join the United States Coast Guard as a third-class petty officer, which brought him to St. Louis. Bahle was admitted to the Coast Guard Academy in Connecticut and graduated in 1943 as an ensign. He then joined the Navy’s amphibious squad where he served as a watch officer on a Landing Ship, Tank for 28 months in the Pacific Ocean, north of the Philippines. On September 2, 1945, as Japan officially surrendered on the U.S.S. Missouri in Tokyo Bay, Bahle and three other officers oversaw the ceremonial surrender of Sasebo, Japan, a prefecture of Nagasaki. That afternoon he became one of the first Americans to walk the streets of post-war Japan. In the summer of 1946 he was reunited with his wife in St. Louis, and the two began their lives together. At St. Louis University Bahle earned his Bachelor’s degree in commerce and finance in 1948 and his law degree in 1952. In 1948 he began his career at Ralston Purina Company, where he would ultimately work for more than 35 years. At Ralston he worked closely with CEO Donald Danforth, eventually acting as his personal assistant and the company’s chief financial spokesperson. In 1984 he retired with the title of vice president and assistant to the chairman of the board. “People less fortunate than we deserve our help. You have to get involved with other people. It’s the only way to learn, to get new ideas, and to grow. I learn something from everyone I meet.” - Mel Bahle In addition to his work at Ralston, Bahle gave back to the community by assisting dozens of nonprofits with their management and organizational stability. He served as chief financial officer and treasurer of the Danforth Foundation from 1955 to 2001, longer than any member of the Danforth family, and continued his role of treasurer until the Foundation’s closure in 2010. Work at other nonprofits included serving as treasurer and board member for the American Youth Foundation, board of control member of Concordia Seminary, board member of the Sit Mutual Fund Group and City Academy, among many others. He also served on civic boards, such as St. Louis County’s zoning board and planning commission. n Sue and Mel Bahle 3 Dr. Tom Smith This information will give researchers more insight on how to manipulate complex viruses as well as to design and develop better drugs to treat the maladies they cause. D i s c over y O f fer s In sight Into Treating N ational S c ienc e Foundation Supp or t s Potentially Dangerou s Vir al Stomach Flu Re s earch Aimed at Reduc ing Fer tilizer U s e Twenty million Americans get sick from norovirus each year according to data released in 2012 by the Centers for Disease Control (CDC). Often called vomiting illness, the norovirus can spread rapidly on cruise ships, in dormitories and hospitals. Recent data from the CDC shows deaths from gastrointestinal infections have more than doubled in the past eight years, and it is a particular threat to the elderly. The virus is shed in the stool of the infected individual, has a short incubation period and can spread quickly if proper hand washing and other measures are neglected. Maize is the most widely farmed crop in the Americas and is highly cultivated worldwide, growing on every continent except for Antarctica. Its adaptability to a widevariety of climate and soil variations is one of the defining reasons for its worldwide popularity. While it is a plant that has been studied at great length, little work has been done to understand its adaptations to varying soil compositions. information, to identify genes controlling the elemental composition of maize. Baxter’s research will identify genes that affect the uptake of mineral nutrients and toxic elements from diverse soils to understand how the soil environment affects the productivity of maize. The goal is to use this information to produce a more nutritious crop that can grow in more environments while using less fertilizer, thereby preserving the environment. The National Science Foundation has awarded $1.3 million to support research that ultimately may lead to maize varieties that are better adapted to low fertility soils, that contain higher levels of essential nutrients, and also decreased levels of metal contaminants absorbed through polluted farmland. The three-year grant will also support training opportunities for young scientists, aspiring scientists, teachers and international scientists. “The USDA Agricultural Research Service lab at the Danforth Center can rapidly analyze large genetic populations of the diverse staple crop,” said Baxter. “The grant addresses issues critical for agriculture, the environment and human health. It will also further our understanding of how soil conditions affect the elemental composition of maize.” While researchers say that vaccines for intestinal infections are among the most difficult to develop, a recent discovery may provide the critical information needed for success. “Sometimes [a virus’] atomic structure gives us clues as to how viruses work and how to make better vaccines,” said Dr. Thomas Smith, a principal investigator at the Danforth Center. Smith’s recently published article about the norovirus in the Journal of Virology was selected by the editors as an “Article of Significant Interest, sighting the extreme norovirus flexibility suggested by these results may allow for broad antibody recognition, a finding of potential vaccine significance.” Smith was part of a team of scientists led by Dr. Peter D. Kwong, a researcher at the National Institute of Allergy and Infectious Diseases, a sub-section of the National Institutes of Health. Their research demonstrated that the virus has a configuration unlike that of other viruses, in that it has protein “lollipop” like structures that likely give it more flexibility in attaching to cells. Dr. Smith and his colleagues discovered that because of the “lollipop” structure, antibodies against the norovirus may be able to bind to the more conserved underside of this floppy structure. This suggests that the extreme flexibility of the norovirus particle may allow for antibody recognition of protected surfaces that might otherwise be buried on intact particles. This information will give researchers more insight on how to manipulate complex viruses as well as to design and develop better drugs to treat the maladies they cause. Rotovirus, a member of a different viral family that also causes severe gastro intestinal distress, primarily in children, is being well controlled by the recent development of a vaccine. n Shown here is an electron microscopy image reconstruction of mouse norovirus (MNV). The protein shell (capsid) is colored according to the distance from the center of the virus particle (virion). The inner shell is colored red and yellow while the protruding domain (P domain) is colored in green and blue. The outer most tip (blue) is used by the virus to recognize the host cell and is where many antibodies bind. There is a yellow strand connecting the P domains to the shell of the virus that likely helps keep the P domains highly mobile and has been observed in three different genera of this family of viruses. 4 “Given the importance of plant-soil interactions as they relate to agricultural efficiency, sustainability and productivity, it is important that more research is done,” said USDA research scientist and assistant member at the Danforth Center, Dr. Ivan Baxter. Dr. Baxter and Dr. Paul Anderson, executive director of International Programs at the Danforth Center, are leading the study, which also includes collaborations with the University of Minnesota, Purdue University and Cornell University. The research will focus on the Nested Association Mapping Population, a unique and powerful resource of genetic To foster education on this important topic, student and teacher internships will be sponsored in St. Louis, Missouri, St. Paul, Minnesota and Ithaca, New York. In addition, educational resources will be developed to assist high school teachers in incorporating bioinformatics and plant molecular biology into their curricula. Participants will also mentor high school students in science through “eScience,” a program utilizing technology to link students and scientists. Dr. Terry Woodford Thomas, director of education and outreach at the Danforth Center, will lead the education component of the program. n Baxter’s research will identify genes that affect the uptake of mineral nutrients and toxic elements from diverse soils to understand how the soil environment affects the productivity of maize. Dr. Ivan Baxter 5 G err y a nd B ob V ir gil: C enter “Friend s” with Remarkable Friend s Many thanks to all of the donors to the Virgil Fund: John & Kay Bachmann John & Crystal Beuerlein David T. Blasingame Mr. & Mrs. Robb Boyd Mr. & Mrs. William H. Broderick III Mr. & Mrs. Morton L. Brown Mr. & Mrs. Daniel A. Burkhardt Mr. & Mrs. Christopher J. Burnes Brett & Lisa Campbell Pam Cavness Jackson Samuel McKay Chauvin Laura & McKay Chauvin Robert J. Ciapciak CSI Leasing, Kenneth B. Steinback & William Gillula Dr. William H. Danforth Mr. Ken Dorn Mr. & Mrs. Norman L. Eaker Edward Jones Mahendra Gupta & Sunita Garg Mr. & Mrs. Douglas E. Hill Jim & Pam Krekeler Tracey & Bill Marshall Timothy Jay McCoy & Family James & Merry Mosbacher Penny Pennington & Mike Fidler Mr. & Mrs. Nicholas L. Reding Lawrence E. Thomas Dr. & Mrs. Robert L. Virgil James & Stacey Weddle Mr. & Mrs. Howard L. Wood Dr. & Mrs. Jess Yawitz Michael & Vicki Zaun On the unseasonably warm afternoon of Friday, March 9, an enthusiastic band of family and friends gathered to celebrate and honor Gerry and Bob Virgil, two of the Danforth Center’s long-standing and exemplary Friends. The occasion, nearly three years in the making, unveiled the newest endowed role created at the Center, the Geraldine J. and Robert L. Virgil Distinguished Investigator. Dr. Todd Mockler, who joined the Center in August of 2011, will be the first to hold the title. (To learn more about Dr. Mockler, see the opposite page.) “The conferral of Distinguished Investigator is our way of recognizing exceptional achievements, contributions and leadership from two different parts of the equation that gives us the Danforth Center,” said Center President Dr. James C. Carrington. “It recognizes a leading scientist who has made, and will continue to make, groundbreaking discoveries that have impact beyond the doors of the Center. And it honors leaders and doers who have given their work, wisdom, treasure and attention to build and grow the Danforth Center.” Dr. Todd Mockler joined the Center in August of 2011. His lab is working to understand the control of plant growth and plant responses to the environment and environmental stresses. Q: In a nutshell, how do you describe your research? A: At its most basic, the question that I’m interested in involves understanding how plant growth is modulated by the environment. This can be anything from heat and cold, to drought, to pests and disease. What I want to understand is what is going on molecularly, what genes are underlying these processes, and what the mechanisms are. Ultimately, if we’re going to have any hope of modifying plant behavior on a large scale, we need to understand how it all interacts. You probably would have no hope of fixing an engine if you had no idea how it functions. I look at it almost like a reverse engineering approach. Q: Your lab is installing a large robotics system, something that hasn’t been seen before at the Danforth Center. How will it work, and what aspects of research will it improve? A: This robotic system will allow us to automate a molecular biology technique called Yeast 1 Hybrid. This will allow us to determine when a protein physically binds to DNA. In early 2009 Danforth Center volunteer Larry Thomas met with Center Chairman Dr. William H. Danforth to contemplate an appropriate way of recognizing the steadfast support Bob and Gerry Virgil have brought to the Center. Ultimately, Mr. Thomas agreed to take the lead in a quiet fundraising effort with Gerry and Bob’s many admirers to create a lasting recognition of their leadership. There are certain proteins in all organisms called transcription factors that bind to DNA and act as switches to turn genes on or off. We know for example that an average plant has about 2,000 of these transcription factors. For only a handful, maybe 20, do we know what genes they regulate. So we know about transcription factors, we know that they bind to DNA, we know that they control gene expression, but in a one-to-one way we can’t say ‘this one controls this gene, this one controls that gene.’ That’s uncharted territory. Under Thomas’ guidance, the funds raised for the Center’s endowment were ultimately sufficient enough to bestow a Distinguished Investigator position. Contributions came from a varied community of Center and Virgil fans, with Edward Jones, from which Bob retired as a General Partner in 2006, and Edward Jones employees joining in as key contributors. This new robot can perform about 200,000 of these DNA protein interaction assays per week. A person can do 2,000 manually, and that would be a person with a pipette working 40 hours a week, and it would be monotonous and grueling, not to mention the likelihood of human error. So this robot will be able to do the work of 100 people per week. At the recognition event, Dr. Danforth commented, “Bob Virgil has been a key part of the Danforth Center’s success as a wise board member and founding chair of the Center’s Friends program. Formerly dean of Washington University’s Olin School of Business, general partner of Edward Jones, and as one of the community’s hardest working volunteers, Bob has brought his understanding of how to build successful organizations, to help strengthen the Center and the many organizations he has touched. Gerry Virgil has been a beloved, enthusiastic and equal partner in these efforts.” The Virgils were touched by the honor. In addition to reiterating their commitment to continue to champion the Center’s vision, Bob remarked, “I still remember the day I learned our friends, under Larry Thomas’s leadership, were endowing a Distinguished Investigator in our name. We were overwhelmed then and we still are. Todd Mockler is an outstanding scientist. Gerry and I are truly honored that Todd is carrying on our name.” Dr. Mockler was equally impressed with the honor, stating, “The Danforth Center provides an opportunity to pursue research in an unparalleled environment for plant science […] the Center’s tight connections to the St. Louis community greatly impressed me during my early visits to St. Louis. I am honored to be part of these connections through the generosity of Gerry and Bob Virgil and their friends.” As part of the ceremony, a new plaque was installed on the Center’s east wall, and honorary medallions were conveyed upon the Virgils and Dr. Mockler. n 6 Ask a Plant Sc ie ntist: Tod d Moc kle r What we’re going to do is systematically interrogate all the possible combinations of the DNA binding proteins in the plants that we’re interested in against all of the regulatory DNA next to the genes. That way we can methodically figure out the network of interactions. It will be like understanding a wiring diagram or the connections on a circuit board. Q: Was there a robotics system at your previous lab? A: No. A big part of my decision to move here was knowing that we would be able to invest in this. The Center’s investments in laboratory automation and biocomputing capabilities will accelerate our research and keep us at the forefront of plant science. Q: From a humanitarian perspective, how can this technology be used? A: When we use the technology to understand the ‘parts list’ and the ‘wiring diagram’ of a plant, then we can make directed modifications. For example, we might identify a DNA binding protein that’s central to plant drought stress response, and then that becomes a candidate for manipulation in corn or wheat. And we’re going to make these discoveries much faster than traditional methods, therefore leading to faster translations to agriculture. So instead of taking approximately 15 years for the next drought resistant soybean, maybe it will be five years. I can’t quantify exactly how much things will accelerate, but it will be significant. n Interested in learning more? Read the extended article at www.danforthcenter.org/askdrmockler 7 U . S . Depar tment of Energ y S elec t s Two Prop o s al s by Danfor th S c ienti s t s Setaria viridis The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) has selected two projects submitted by Danforth Center Principal Investigators, Drs. Thomas Brutnell and Todd Mockler, as part of its 2012 Community Sequencing Program (CSP). The 2012 CSP call invited researchers to submit proposals for projects that advance capabilities in fields such Dr. Thomas Brutnell as plant-microbe interactions and metagenomics. This data will enhance research projects that aim to improve biofuel feedstock production, focusing on the potential of microorganisms to improve feedstock growth and prevent devastating diseases that hinder yields. Both setaria and brachypodium are useful model crops for a variety of grasses that are candidates for biofuel production The project proposed by Drs. Brutnell and Mockler will develop sequence-based community tools for the plant Setaria viridis, a model genetic system for bioenergy grasses. Brutnell, Mockler, and colleagues from the University of Georgia, the University of Missouri-St. Louis, and Oklahoma State University, will use highthroughput sequencing technology to rapidly advance genetic resources in setaria. Setaria is quickly emerging as a model system for bioenergy grasses, as it is closely related to primary bioenergy feedstock crops such as switchgrass, miscanthus, and sugarcane, but it is a much more manageable genetic system. This project will include providing sequence blueprints for more than 50 diverse varieties of setaria, as well as providing the data to facilitate the development of mutagenized populations and lines that can be used to map genetic variation. The development of these genetic resources will enable scientists to identify genes that contribute to a number of traits that are essential to promoting efficient biomass production, including increased stress tolerance, and water and nitrogen use efficiency. The second Danforth related project chosen by the JGI will create a library of grass transcription factors for the energy crop model system Brachypodium distachyon. Dr. Mockler is a co-principal investigator with Dr. Samuel Hazen at the University of Massachusetts. Brachypodium is a grass that serves as a model for potential energy crops such as switchgrass, sorghum, and miscanthus, as well as for the cereal crops that constitute a large portion of the world’s diet. Transcription factors are proteins that regulate whether a gene is turned ‘on’ or ‘off,’ and the brachypodium transcription factors targeted in this project are implicated in the regulation of growth and biomass accumulation. Hazen, Mockler, and their collaborators will use this project as the cornerstone of a new high-throughout platform for analyzing protein-DNA interactions for the purpose of understanding important traits in grass species. (To learn more about transcription factors, see page 7.) These grants will provide a huge boost to the development of these two model grasses and will greatly accelerate the ability of scientists to translate basic scientific discoveries into application. Brachypodium distachyon 8 “The Enterprise Rent-A-Car Institute for Renewable Fuels at the Danforth Center has a strong foundation in developing algal and seed oil biofuels. These new grants will expand the Institute’s portfolio to include the development of model systems for lignocellulosic feedstocks,” said Brutnell. “I am particularly excited about the prospects of the Danforth Center becoming a leader in molecular tool development for these model grasses.” n 2011 Donald Danfor th Plant Sc ie nc e Ce nter C o ntri b u ti o ns Many thanks to the following donors who have provided critical endowment, annual fund and other support for the Donald Danforth Plant Science Center in 2011. Through the ongoing support, loyalty, interest and generosity of many, the Danforth Center can live up to its commitment to excellence now and in the future. The names of Charter Members of our donor programs are indicated with an asterisk. E n d ow m e n t G i f t s Anonymous Mr. & Mrs. Daniel A. Burkhardt The Danforth Foundation Dr. William H. Danforth Nancy & D.J. Diemer Edison Family Foundation Harry Edison Foundation Mr. & Mrs. David C. Farrell Mr. & Mrs. David P. Gast JSM Charitable Trust Mr. & Mrs. Kenneth Kranzberg John & Anne McDonnell Mr. & Mrs. J. Patrick Mulcahy Mrs. Laura Orthwein Mabel Purkerson, M.D. Mabel D. Reeder Foundation Doris I. Schnuck Mark & Stephanie Schnuck Scott & Julie Schnuck Terry & Sally Schnuck Jack C. Taylor Special Restricted Gifts Anonymous David T. Blasingame Mr. & Mrs. William H. Broderick III Mr. & Mrs. Morton L. Brown Pam Cavness Laura & McKay Chauvin Robert J. Ciapciak Dr. William H. Danforth CSI Leasing, Kenneth B. Steinback & William Gillula Edward Jones Mahendra Gupta & Sunita Garg Mr. & Mrs. Douglas E. Hill J.P. Morgan Foundation Tracey & Bill Marshall James & Merry Mosbacher Mr. & Mrs. Nicholas L. Reding Lawrence E. Thomas Mr. & Mrs. Howard L. Wood Dr. & Mrs. Jess B. Yawitz Michael & Vicki Zaun Plant Science Patron P l a t i n u m - ($100,000 + ) Dr. William H. Danforth* Plant Science Patron G o l d - ($50,000 + ) Anonymous Mr.+ & Mrs. Melvin C. Bahle* The Boeing Company Plant Science Patron S il v e r - ($35,000 + ) Mr. & Mrs. Robert W. Prather IV* Spoehrer Family Charitable Trust Plant Science Patron - ($25,000 + ) Dennis & Rowena Bennett Elizabeth Danforth* Mr. & Mrs. Norman L. Eaker* Mr. David W. Kemper; William T. Kemper Foundation, Commerce Bank Trustee Richard & Susan Kiphart Mrs. Mary Ann Lee John & Anne McDonnell* Philip & Sima Needleman Maebelle Reed* Dr. & Mrs. Robert L. Virgil* Mr. Blanton J. Whitmire Plant Science Benefactor - P l a t i n u m - ($20,000 + ) The Albers/Kuhn Family Foundation Janet & Bernard Becker, The Horncrest Foundation, Inc. Ms. Jane McCammon Dr. & Mrs. Jess Yawitz Plant Science Benefactor - G o l d - ($15,000 + ) Hon. & Mrs. John C. Danforth* Janet M. & Newell S. Knight, Jr.* Novus International, Inc.,Thad & Betty Simons Plant Science Benefactor - ($10,000 + ) Brett & Lisa Campbell James & Teri Carrington Michael Dwyer Peggy Fossett Fox Family Foundation Ms. Jane Goldberg* Hugh & Janice Grant Sally & Ned Lemkemeier* Ann & Lee Liberman* Walter & Cynthia Metcalfe* Mrs. William J. Oetting* Peters Family Charitable Fund Mr. & Mrs. Donald L. Ross Mr. & Mrs. Andrew C. Taylor Mr. & Mrs. Robert Tschudy* Dr. Virginia V. Weldon* Plant Science Paceset ter - G o l d - ($7,000 + ) Dr. & Mrs. Roger N. Beachy* Mary Ranken Jordan & Ettie S. Jordan Charitable Foundation Todd & Julie Schnuck Plant Science Paceset ter - ($5,000 + ) John & Kay Bachmann Bank of America Charitable Foundation, Inc. Dr. John H. Biggs & Mrs. Penelope Biggs Jerry & Rosalie Brasch Bunge North America Foundation Mr. & Mrs. Daniel A. Burkhardt* Michael W. Cramer EPL Bio Analytical Services Mr. & Mrs. David C. Farrell* Dr. Katharina Lodders-Fegley & Dr. Bruce Fegley, Jr. Mr. & Mrs. David P. Gast The Catherine Manley Gaylord Foundation Mr. & Mrs. Thomas R. Green Sally Higginbotham Dr. Jan G. Jaworski & Dr. Martha A. Post* Mr. & Mrs. James L. Johnson III Dr. & Mrs. W. R. Konneker Mr. & Mrs. Kenneth Kranzberg Mr. Donald E. Lasater The Family of Edwin Levis Jr. Mr. Leslie F. Loewe & Mrs. Jean Agatstein Mrs. Lucy Lopata Mrs. Dotty Miller* Oakwood Medical Investors Mary Dell Pritzlaff Prolog Ventures, LLC Charles M.M. & Susanne W. Shepherd Staenberg Family Foundation Mr. & Mrs. Eugene M. Toombs Ambassador & Mrs. George Walker, III Heather Wood Plant Science Ambassador - Gold - ($3,500 + ) Mr. & Mrs. Blackford F. Brauer Mrs. Donald Danforth, Jr.* Carl & Jeanne Deutsch Foundation* Harris J. Frank Dr. & Mrs. Ernest G. Jaworski* Margaret A. Kiefer F. Vincent Leeder Mr. Ted Medlin Tina & Jack Niemann Mr. David T. Orthwein Dick & Susan Russell Barry & Dale Sharon Keith & Ginny Smith Mr. & Mrs. James von der Heydt* Mr. & Mrs. Richard K. Weil Plant Science A m b a s s a d o r - ($2,500 + ) Mr. & Mrs. F. Gilbert Bickel, III Steve & Kelly Bloom Mr. & Mrs. Jack Bodine Andy & Susie Corley Arnold & Hazel Donald* Edison Family Foundation Dr. & Mrs. William C. Finnie* Dr. Rebecca Messbarger & Mr. Sam Fiorello* Mrs. Charles Guggenheim* Mr. & Mrs. Paul H. Hatfield Dr. & Mrs. S. Allen Heininger Mrs. Edward D. Jones, Jr.* Mr. Wesley Jones & Mrs. Nancy Ylvisaker Chuck & Jan Mueller Jane Nelson & Dale Isaak* Jay & Lisa Nouss Chuck & Sue Oertli Rachel & Jack Oliver Paric Corp. Raul & Mary Ellen Perez Gordon & Susie Philpott Kathy & Doug Pope Milton & Jane Rand Tarlton Corp. Henry & Pam+ Winkelman Mark S. Wrighton & Risa Zwerling* Plant Science Par tner P l a t i n u m - ($2,000 + ) Anonymous George L. Fonyo Mr. & Mrs. Thomas C. Melzer Anita & John O’Connell Dr. & Mrs. William Peck Emily & Derek Rapp* St. Louis County Economic Council Ms. J.J. Stupp Jane & Pat Tracy Plant Science Par tner G o l d - ($1,500 + ) Mr. Brett Begemann Mr. Bruce S. Buckland Laura & McKay Chauvin Mr. & Mrs. Christopher B. Danforth* Dr. & Mrs. James W. Davis Nancy & D.J. Diemer Gretta Forrester Mr. Sidney Guller Audrey B. Lytle James & Judith McKelvey Constance & John McPheeters Drs. Ellen & Thomas Moran Rita Mumm Kathleen & Sandy Rogers Beth & Donn Rubin RubinBrown Charitable Foundation Mr. & Mrs. Harvey Saligman Mr. & Mrs. John T. Sant Sally & Gerry Schwartz Jerry Steiner & Denise Bertrand Mr. & Mrs. Donald H. Streett William & Anne Tao* Plant Science Par tner - ($1,000 + ) Mr. & Mrs. Vincent Abernathy Dr. & Mrs. Paul Anderson Anonymous Frank & Mariann Baker Tom & Cindy Bander Mr. & Mrs. Clarence C. Barksdale* Ms. Debbie Barron Mr. & Mrs. Van-Lear Black III Lee Bohm Mr. & Mrs. John F. Bohney Ken & Mary Bower Mr. William R. Boyle Mr. & Mrs. Robert G. Brandt Mr. & Mrs. Harold Bray Mrs. Billie Broeker* Mr. & Mrs. A. Van L. Brokaw David & Kathleen Broughton* Ms. Jane D. Bryan Will & Hellen Carpenter Ann & Mike Case John H. Cassidy Katie & Charlie Claggett Tom & Meg Claggett Mr. & Mrs. Charles H. Cobaugh Mr. Andrew B. Craig III* Mr. & Mrs. David M. Culver Roy Curtiss & Josephine Clark-Curtiss Stephanie & John Dains Hal Davies* Mr. & Mrs. Philippe de Laperouse Jack M. & Sherry B. Delo Dr. Ira DeWitt & Mr. William DeWitt III Dr. & Mrs. Edward A. Doisy III* Dr. & Mrs. Robert C. Drews Ellen & Henry Dubinsky John & Yvette Dubinsky Carol McCarthy Duhme Mr. & Mrs. Julian I. Edison Dr. Ron & Hanna Evens Dr. & Mrs. Thomas B. Ferguson Vincent & Lynn Ferrari Steven & Linda Finerty Mr. & Mrs. William B. Firestone Chris & Megan Frank, Cfx * Indicates Charter Member + Deceased 9 Roberta (Robbye) Frank Robyn & Victor Frankel Dr. Ira & Judy Gall Joe Glik Joan & Joseph Goltzman Mark & Michele Gorski Ellen & John Grimes Laurie & John Haffenreffer Gary & Bonnie Halls Janis M. & Mark E. Halsey Mrs. Anna Harris* Harvey & Judy Harris Mr. & Mrs. Kenneth Hartley Mr. & Mrs. A. Charles Hiemenz III Mr. Briggs A. Hoffmann, Jr. Inovatia Laboratories, LLC Dr. Peter Wyse Jackson William & Holly James Mrs. Bettie S. Johnson Michael Kalishman Mr. & Mrs. Myles P. Kelly Ashley & John Kemper Dr. & Mrs. James R. Kimmey Ward & Carol Klein Mrs. Donald Klingler* Mr. & Mrs. Gunther Kohn Dr. Stuart Kornfeld & Elizabeth Loeb Cynthia Kramer Mr. & Mrs. M. Paul Kravitz Dr. Toni Kutchan Emily & Bill Kuzma Nikki & David Lemkemeier Carol B. Loeb Dr. Ed Magee & Lorraine Magee Linda M. Martinez* Mr. & Mrs. Hamish Maxwell Mr. & Mrs. Sanford N. McDonnell Foundation Dr. & Mrs. James S. McLaren Dr. & Mrs. Roger Mell David Mesker Lewis R. Mills Millstone Foundation Mrs. Clifford W. Murphy Mary Ann & Fred Noel* Paul & Nancy Pautler Mrs. Stella C. Pettus+ Mary Jo & Bob Proost Sue & Kip Rapp Mary & Frank Rassieur Dan & Mary Riew Dr. & Mrs. Ronald Riner Karla R. Roeber The Rosebud Foundation Mr. & Mrs. John W. Rowe Ronald S. Saks Cary & John Schaperkotter James & Joan Schiele Ulrike & Tom Schlafly* Marie L. & Walter D. Schmitz Mrs. Edward Schnuck Mr. & Mrs. Michael Scully Mr. & Mrs. Bob Senseman Dulari & Dilip Shah Mr. & Mrs. John C. Shapleigh Mr. & Mrs. David S. Sherman, Jr. Nanne B. Simonds Raymond G. Slavin, M.D.* Dr. & Mrs. William S. Sly Emily L. Smith, M.D. Mr. & Mrs. Sanford Spitzer Mrs. Moir Stevens Bud & Anne Strong Maurita E. Stueck Julie Kohn & Dan Swift Peggy Walter Symes Dr. Janey Symington & Mr. Stuart Symington Jessie L. Ternberg, M.D. Dr. Lewis J. Thomas, Jr. John & Georgia Van Cleve Colwell* Andrea & Peter Van Cleve William & Barbara Van Luven Donna & Gary Vandiver Joe & Margaret von Kaenel Bob & Nancy Wagoner Drs. Ling Zheng & Xuemin (Sam) Wang 10 Mrs. Ted C. Wetterau Dr. & Mrs. Bruce I. White Alwyn E. & Bonnie Barton Wolfarth John J. Wolfe, III+ Matt Wolfe Usha B. Zehr Dr. Meinhart Zenk+ U n d e r w r i t e r - ($500 + ) Bruce & Ann Anderson* Anonymous Nancy L. Bartlett & Steve Hiotis Holly Benson Mrs. Virginia B inzel Catherine S. Bollinger Mr. & Mrs. Harold Burroughs Don & Carol Carlson Mary E. Clutter Mr. & Mrs. Herbert D. Condie Michael & JiaMin Dierberg Mrs. Ellen M. Doiron Mr. & Mrs. John F. Donnell Echo Valley Foundation Mr. & Mrs. Bernard Edison Mr. & Mrs. G. Patrick Galvin Richard Hedden Mich B. Hein & Beth Bray Hellmuth, Obata & Kassabaum Phil & Shirley Hellwege ICS Construciton Services, Ltd. Mrs. Nancy Kalishman Dr. Joe Kamalay & Dr. Paulette Pierson Dr. & Mrs. David M. Kipnis Mr. & Mrs. Richard A. Liddy Pam Lokken & Andy Sobel Mr. Robert Lubben Mr. & Mrs. Franklin Mange Dr. Kenneth R. Mares Mimi McDonald & Jennifer McDonald Mr. Jeffrey McDonnell Mr. & Mrs. Robert McDowell Mrs. Clara E. McLeod Plumbers & Pipefitters Local #562 Madelon Price David R. Riedel, M.D. Sandy & Susan Rothschild Dr. & Mrs. Joseph G. Sandza Richard & Katie Sayre Dr. & Mrs. Larry J. Shapiro Shea Smith, III Mary Beth & Allen Soffer Mr. & Mrs. Clarence M. Turley Charles & Nancy Van Dyke Jeremy Williams & Rachel Presti A d v o c a t e - ($250 + ) Benjamin Abrams Anonymous Stanko Banjanin & Dr. Milica Banjanin Dr. R. Howard Berg Mr. & Mrs. Bradley Bishop Mr. William C. Bitting Mr. & Mrs. B.A. Bridgewater, Jr. Mr. & Mrs. Douglas S. Brown Powell & Kelley Carman Chris & Anne Chivetta Debbie & Dave Cole Common Ground Public Relations, Inc. Mr. & Mrs. William E. Cornelius David & Harriet Cronin Peter E. Dolan & Anne Adderton Kitty Drescher Patricia Drew Charlotte M. Eldredge Mr. & Mrs. N. 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Pierce Judy & Paul Putzel Mr. & Mrs. Milton L. Rand, Jr. Mr. & Mrs. Richard Robb Hope Jones Rouse+ Daniel Schachtman & Ellen Marsh Mr. & Mrs. Peter Schlafly Paul & Darlene Schoon Janet & Michael Sheahan Margie R. Skiljan Diane & David Snively Mrs. Donna Stephens Frank & Teg Stokes* Ken Streett Sigrid & Robert Thach Dr. & Mrs. Henry Uhlemeyer John & Dea Vallina Alice H. Vosburgh Daniel Waxler Wedgewood Partners, Inc Paula & Ron Wepprich A s s o c i a t e - ($100 + ) Mr. & Mrs. M. M. Alexander Alpha Dental Care Ms. Anne Anderson R.S. Anderson Anonymous Dr. Basavaraj Bagewadi Mrs. Mary Randolph G. Ballinger Mr. & Mrs. William J. Barnard Morton Bearman Richard P. Redel & Judith Beckerle Dr. & Mrs. Donald T. Behrens Mrs. Ruth Bock R.E.A. Homes, LLC. Dr. & Mrs. George Bohigian Betsy Boles Thomas H. & Janet G. Boudinet Mr. & Mrs. Matthew C. Brokaw Allison Brown Charles & Marlene Buescher Dr. J.J. Burke Dr. Alberto Carbonell Olivares Marie & Mark Carlie Mr. J. Christopher Carroll C.K. (Chip) Casteel, Jr. Michael & Ene Chippendale Dr. Molly Cline & Dr. Steven Cline Norman M. Coats George C. Convy Alice E. Conway Mr. & Mrs. James K. Cook Steven & Holly Cousins James Cox Gary D. Curl & Carol Jones Curl Rand Dankner Mrs. Nancy W. Day Dr. Jonathan & Patricia Dehner Paul M. Denk Mr. & Mrs. Robert P. Dieckhaus Patricia & Harold Dielmann Betsy & Tom Douglas Dr. T. J. Dubuque Sue & Harry Estill Gary & Doris Ferguson Karen Johnson Fields Joanne & Bill Fogarty Ilene & Burt Follman Roger & Carol Frederickson Judge Gary M. Gaertner, Jr. & Mrs. Julie Gaertner Dr. & Mrs. Joe Gerard Mr. Marcus Geringer Mr. & Mrs. Peter A. Gleich Mr. & Mrs. Alan P. Goldberg Patricia D. Graf Mrs. Anita S. Graves Dr. Mary Jane Gray Eric A. Gulve, Ph.D. Mark & Trish Gunby Jean C. Hamilton Ken & Debby Hand Hazelwood Parks & Recreation Edith Hegg John C. (Jack) Heisler & Anne Heisler Michael & Terri Hennessey Jim & Nancy Hershey Dr. & Mrs. John C. Herweg Mrs. Arthur C. 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Staack Peter Stahnke Ned Stanley Mr. & Mrs. Daniel Steinmeyer Mr. Richard T. Stith Jr. Mr. & Mrs. Robert Streett Lori A. Sullivan & G. Todd Rogan Dr. Robert A. Swarm & Ms. Sharon Parker Lawrence Taylor Ms. Brenda Teakert Chandra & Richard Thurman Betty & Thomas Tobben Dr. Elaine Tobin Ihuoma C. Umezurumba J.B. & Dori Waggoner Mr. & Mrs. Ralph Waterman Laurie Waters & Ellis Taylor Susan & Denny Wedemeyer Wednesday Club of St. Louis Murray & Phyllis Weidenbaum Vicki Gonzalez & Stephen Welker Geraldine Werner Jim White & Cindy Payant Matthew Wichmer Ted Wight Ronald A. & Anita Williamson William H. Wisbrock Kay Wood Mr. & Mrs. Kenneth J. Wulfert Mr. & Mrs. Andrew Youkilis Young President’s Organization Mrs. Deborah Zacher Mr. & Mrs. Rafael P. Zamora Other Gifts Dr. & Mrs. C. William Ade Mrs. Joan M. Althaus Anonymous Ms. Melanie Bernds Nancy & J.S. Billingham Mr. David Blake, Jr. Eli Blavin Mr. Steven B. Brandes Emilie P. Brandhorst Mr. Robert H. Branom, Sr. Mr. Kerry R. 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E li z a b e t h G r ay Danfor th Mrs. Charles Guggenheim Mimi McDonald & Jennifer McDonald Mr. & Mrs. Jack Bodine To m B a n d e r Mr. & Mrs. John F. Donnell D r. R o g e r N . B e a c h y Laura Chauvin Wednesday Club of St. Louis D r. W illi a m H. D a n f o r t h Tom & Cindy Bander Laura & McKay Chauvin Mary E. Clutter Mrs. Donald Danforth, Jr. Mr. & Mrs. Earl D. Derouin Mr. & Mrs. David C. Farrell Sally & Ned Lemkemeie Ann & Lee Liberman Mimi McDonald & Jennifer McDonald Mary Ann & Fred Noel Milton & Jane Rand Mr. & Mrs. Richard K. Weil Dr. Virginia V. Weldon Young President’s Organization T h e H a u c k F a m il y Michael Dwyer Sylvan Fr y Jan Jaworski L o is & Wa ll a c e Tu t t l e Jim & Janet Knight Joe Glik Experience Inc. Bob & Joan Jasper Tom & Cindy Bander Laura & McKay Chauvin Mrs. Stephanie Riven & Mr. Roger Goldman Mrs. Arthur C. Hiemenz Jr. Milton & Jane Rand A ll a n C a r l K n a b e Janet M. & Newell S. Knight, Jr. Ro ge r K r u e ge r Benjamin Abrams A n n D. L a i r d Mr. Leslie F. Loewe & Mrs. Jean Agatstein Michael Dwyer Bruce Hig ginbotham Dr. Jonathan & Patricia Dehner Ms. Liz Higginbotham Butch & Cindy Jasper Mr. & Mrs. Harold H. Schreimann Luke Kissam & Kathryn Schanen Kissam Mr. & Mrs. James W. Metcalfe To n i K u t c h a n O li v e r L a n ge n b e r g Lee M. Liberman J o h n P. M a gu i r e M r. & M r s . J. K e n t McHose Ann & Lee Liberman Mrs. Adrienne J. Shuter Frances Nouss Te d M e d li n Tom & Cindy Bander Hon. & Mrs. John C. Danforth Mr. & Mrs. John F. Donnell D.C. R u c ke r, J r. Powell & Kelley Carman Wa l t e r M e t c a l f e Charles M.M. & Susanne W. Shepherd A li c i a M u h m D r. C l a r e n c e “B u d” R y a n R e v e r e n d J.O. R a n d Mrs. Patricia Ryan S e y m o u r S e l t ze r Joe Glik B e r n i e Tr a c h t m a n Laura & McKay Chauvin Peg Whitmire Gary D. Curl & Carol Jones Curl B e a n Wo l f e Laura & McKay Chauvin B i z Wr i g h t Mrs. William J. Oetting R e v. A ll a n Z a c h e r, P h. D. Mrs. Deborah Zacher Meinhar t Zenk Janet M. & Newell S. Knight, Jr Mr. & Mrs. Oliver M. Langenbergh Mr. Ted Medlin Mrs. William J. Oetting Mr. & Mrs. Charles E. Walton Joe Glik Milton & Jane Rand J a n e & M il t R a n d Mrs. William J. Oetting Mr. & Mrs. Milton L. Rand, Jr. D r. & M r s . D o n S a u e r Mrs. Adrienne J. Shuter J a n e y S . S y m i n g t o n, P h. D. Janet M. & Newell S. Knight, Jr. A n d y & B a r b a r a Ta y l o r Mr. & Mrs. Donald L. Ross M r. J a c k C. Ta y l o r Ellen & John Grimes M a t t Wo l f e Dudley & Beth McCarter C h a n c e ll o r M a r k Wr i g h t o n & R is a Zw e r li n g Mary Jo & Bob Proost 11 NONPROFIT ORG U.S. POSTAGE DONALD DANFORTH PLANT SCIENCE CENTER 975 NORTH WARSON ROAD ST. LOUIS, MISSOURI 63132 USA PAID ST. LOUIS, MO PERMIT NO. 5385 Address service requested Pla n t T h e s e o n Yo u r C a l enda r A P R E L I M I N A R Y L O O K AT U P C O M I N G E V E N T S I N 2 0 1 2 Conversations “A CONSERVATION CONVERSATION” THURSDAY, MAY 10, 2012 and 5:15 PM Reception followed by event Join Andy Taylor, chairman and CEO of Enterprise Rent-a-Car, and Mark Reuss, president of General Motors, North America, for a dialogue about corporate social responsibility/sustainability. Includes thoughts on how doing the right thing can be right for the consumer and good for business. MONDAY, JUNE 4, 2012 5:15 PM Reception followed by event A Danforth Leadership Council event featuring Jim McKelvey, cofounder of the mobile payment company Square. FRIDAY, JUNE 22, 2012 7:30 AM Reception followed by presentation Sponsored by: Andy Taylor Jim McKelvey Mark Reuss All dates are subject to change. Please visit www.danforthcenter.org for more info 30