2013 annual report - Fred Hutchinson Cancer Research Center
Transcription
2013 annual report - Fred Hutchinson Cancer Research Center
2 0 1 3 ANN UA L R EP O RT Ending cancer is a bold goal, but it is one that can be achieved by working together. Every day, Fred Hutchinson Cancer Research Center scientists collaborate with colleagues, physicians, study participants and thousands of private supporters to save lives. Your support is more important than ever before: Join us in celebrating our shared successes. Together we can end cancer. 2 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Matt Hagen M E S S AG E F R O M D R . L A R R Y C O R E Y, P R E S I D E N T A N D D I R E C TO R Wit h yo u r hel p, F red H ut ch is fo cus ed o n e lim i na t i ng ca n cer a n d o t her dis eas es T he theme of our annual report this life and his accomplishments. Don’s volunteer, and corporate and community year, Ending Cancer Together, is a achievements, which have saved the partner who supports their research distillation of Fred Hutchinson Cancer lives of hundreds of thousands of people shares in that legacy. This report Research Center’s core strategy. Since around the world, were born of his gift highlights just a handful of the many our inception, we have been focused on for bringing exceptional people together collaborations that sustain Fred Hutch’s eliminating cancer and related diseases and inspiring them all to pursue the efforts to end cancer. as causes of suffering and death through singular goal of making bone marrow the concerted work of a diverse and transplantation (BMT) into a lifesaving dedicated community. medical therapy. BMT was and still is, in Dr. E. Donnall Thomas knew the necessity of this collaborative approach. Don, who passed away in October 2012, will forever be remembered as the father of bone marrow transplantation because of his resolute efforts to establish the treatment as a cure for leukemia and other blood diseases. my opinion, medicine’s most complex procedure. The procedure requires a wide variety of skills from laboratory scientists to incredibly skilled nurses, pharmacists and caretakers — all orchestrated into the interrelated efforts of curing leukemia and lymphoma. Don gave us a model for selfless, I extend my gratitude to all whose contributions and energy enable us to continue pioneering better care for patients. The generosity of our benefactors and volunteers, the fortitude of our patients and families, and the audacity of our researchers never fail, and they never fail to inspire me. I look forward with great anticipation to another year of enduring partnerships and new connections that will only But he did not succeed alone — focused teamwork which everyone enhance Fred Hutch’s ability to improve something vividly evident when we all affiliated with Fred Hutch follows to this human health and save lives. gathered last fall with his wife, Dottie, day. Every researcher and staff member their children, and so many of his who strives for the next breakthrough friends and colleagues to celebrate his and every benefactor, study participant, 3 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Rem embering t he fat her o f b o ne m arro w t rans plant at io n D R . E . DO N N A L L T H OMAS PIO N EERED B O N E MA RROW TR ANS P LANTATION AN D R E C E I V ED T H E N O B EL PRIZE IN PHYSIO LO GY O R M ED ICINE IN 1990. Photo by Suzie Fitzhugh C O N T I N U E D N E X T PAG E > DR. E. DO N N A L L THOMAS ACCEP TING TH E 1 990 N O B EL PRIZE IN P H YS IOLOGY OR MED ICINE. Photo courtesy of Nobel Foundation T he world lost one of the greatest figures in 21st century by Thomas on the use of bone marrow transplantation as a medicine when Dr. E. Donnall Thomas died on October treatment for leukemia. 20, 2012, at the age of 92. For his pioneering work developing bone marrow The radical concept captured Appelbaum’s imagination, and he dedicated his studies and career to the emerging field transplantation, Thomas received the 1990 Nobel Prize in of transplantation research. In 1977, Appelbaum was working Physiology or Medicine. His work was foundational in the at the National Institutes of Health, researching marrow creation of Fred Hutchinson Cancer Research Center in transplantation, when Thomas himself called to offer a position Seattle. With more than 1 million bone marrow transplantations at the Hutch, which had opened in Seattle two years earlier. performed throughout the world, Thomas’ work has touched – and saved countless lives. One of the people deeply affected by Thomas was his friend and protégé Fred Appelbaum, newly named Hutch deputy director and longtime director of Fred Hutch’s Clinical Research Division and executive director of the Seattle Cancer Care Alliance. In 1970, Appelbaum was a medical student when he It was an incredible turn of events for Appelbaum, who had closely followed Thomas’ pioneering research ever since he picked up that medical journal in 1970. “Honestly, to me, it was like the heavens opening, God looking down and saying: ‘Would you like to come to Seattle?’” he said. It was the start of a long friendship and collaboration that helped to establish Appelbaum as a leading expert in transplantation research and care. happened to pick up a medical journal featuring a paper C O N T I N U E D N E X T PAG E > 5 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T NE W LY N A M ED H UTC H D EPUTY DIRECTO R F RED A PPEL B AUM WAS INS P IR ED TO STU DY TR ANS P LANTATION BY D ON TH OMAS . Photo by Matt Hagen To Appelbaum, Thomas epitomized the classic image of the Thomas came to Seattle in 1963 to be the first head of the physician-researcher who cares deeply for his patients and Division of Oncology at the University of Washington School dedicates his life to the science of helping countless others. of Medicine. Thomas led a small team that sought to do what “Don was a hero. He was, by far, the most influential person in my career, and I know that many others would say the same thing,” Fred said. At Fred Hutch, where he was a mentor and inspiration to so many, Thomas was a larger than life figure who was also counted by many as a dear friend. “To the world, Don Thomas will forever be known as the father of bone marrow transplantation, but to his colleagues at Fred Hutch he will be remembered as a friend, colleague, mentor and pioneer,” said Dr. Larry Corey, president and director of Fred Hutch, shortly after Thomas’ death. “The work Don did to establish marrow transplantation as a successful treatment for leukemia and other otherwise fatal diseases of the blood is responsible for saving the lives of hundreds of thousands of people around the globe.” many medical experts at the time were convinced would never work: cure leukemia and other cancers of the blood by destroying a patient’s diseased bone marrow with nearlethal doses of radiation and chemotherapy, and then rescuing the patient by transplanting healthy marrow. The goal was to establish a fully functioning and cancer-free blood and immune system. Alongside his research partner and wife, Dottie – a trained medical technologist – Thomas stubbornly pursued transplantation throughout the 1960s and 1970s. At the time, hematologists and oncologists preferred to treat patients with drugs, and prevailing thought was that the transplant procedure was so radical and dangerous it was unethical to administer to patients. But years of research advances by Thomas and his colleagues steadily improved bone marrow transplantation C O N T I N U E D N E X T PAG E > 6 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T “Every cancer center would aspire to creating new approaches to curing cancer, but very few have had that good fortune. Don and Dottie’s work created a completely new paradigm of cancer treatment that we continue to exploit to this day.” – Nobel Laureate and Fred Hutch Director Emeritus Lee Hartwell D ON AND D OTTIE TH OMAS AT 2005 PATIENT R EU NION. Photo by Jim Linna and reduced the risk posed by its side effects. That progress, One of Appelbaum’s favorite stories about Thomas’ humble as well as the procedure’s potential, convinced Seattle spirit came from the day he received word that he won the surgeon William Hutchinson to support Thomas and his team Nobel Prize. When Thomas came to work at the hospital that by establishing their own dedicated research facility. Fred day, the first thing he did was to go to the nurses’ station and Hutch broke ground in 1972 and opened in 1975. congratulate and thank his colleagues all for the work and In 1974, Thomas joined the Hutch’s faculty as its first director of medical oncology. He later became associate director and eventually director of the Clinical Research Division. He stepped down from that position at age 70 in 1990 and officially retired from the Hutch in 2002. dedication they had shown. “He was incredibly generous to his team. It’s just the kind of man he was,” Appelbaum said. Don Thomas is survived by his wife, Dottie, and their three children, eight grandchildren and one great-grandchild. n During his tenure at Fred Hutch, Thomas recruited scientists and physicians who could help address each of the numerous challenges associated with transplantation. “Every cancer center would aspire to creating new approaches to curing cancer, but very few have had that good fortune. Don and Dottie’s work created a completely Fred Hutch’s bone marrow transplantation research is new paradigm of cancer treatment that we continue to exploit made possible in part through the contributions of to this day,” said Dr. Lee Hartwell, Fred Hutch director emeritus and 2001 Nobel laureate, in a video commemorating Thomas’ life. 7 numerous benefactors, including a generous gift from Dr. Steve Collins made in memory of Dr. Don Thomas. F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T D R. H A N S- P E T ER K I E M, CEN TER, DR. J EN N IF ER A DA IR, LEFT, AND PATIENT CH AR LIE BU R GES S , LOOK AT P R OTEIN DATA, KNOWN AS W EST ER N BLOTS , DERIV ED F RO M CHA RL IE’S OWN SA M P LES . Photo by Matt Hagen ‘Th e ca ncer i s rea l l y go ne’ O n the Fourth of July in 2009 Charles Burgess experienced the first symptoms of the aggressive brain cancer that would change his life forever. Charlie, as his friends and colleagues call him, had a “I would slip away and slip back. I was confused. My friends thought I was having a stroke,” Charlie said. Within the next week, tests would confirm what Charlie’s medical training had led him to suspect: A demanding but rewarding career working as a psychiatrist. glioblastoma tumor was growing fast within his brain. The Serving his Homer, Alaska community, he treated patients news only got worse from there. including children and the elderly, over a large territory. The holiday was a rare chance to relax with family and friends, but the celebration ended abruptly when Charlie blacked out. When he came to, he couldn’t speak. For glioblastoma patients like Charlie, the average survival time is just 12 months, and no one survives longer than four years. It was a prognosis Charlie wouldn’t C O N T I N U E D N E X T PAG E > 8 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T accept. He had a community that needed him, a daughter entering college in the fall and his wife of 40 years whom he planned to be with for many more years to come. “I was determined to fight,” Charlie said. So Charlie assembled a team of advisers that included doctors and a social worker with 30 years of experience supporting cancer patients. Charlie’s team supported his decision to enter a radical clinical trial being led by Dr. Hans-Peter Kiem at Fred Hutchinson Cancer Research Center in Seattle. Kiem’s approach was completely new. It called for protecting healthy cells with a gene therapy while attacking cancer cells with a powerful type of chemotherapy. It was a long shot, but it was the best one Charlie had. CH AR LIE BU R GES S , LEFT, IS GR EETED BY D R S . JENN I FE R A DA I R A ND H ANS -P ETER KIEM IN TH E LOBBY AT FR ED H U TCH . Photo by Matt Hagen For Charlie’s type of cancer, chemotherapy is combined with a second drug called benzylguanine. Benzylguanine helps “Without protecting the blood cells, most patients might kill tumor cells by preventing them from repairing the severe receive one or two cycles of therapy; the most any patient DNA damage caused by the chemotherapy. Unfortunately, before ever received was four cycles. Charlie was able to benzylguanine also kills blood cells. The result: Physicians receive nine,” said Dr. Jennifer Adair, a member of Kiem’s have a powerful therapy they cannot fully use. research group. To offer such patients potentially curative amounts of The therapy regimen was tough, but Charlie and the Fred chemotherapy, Kiem developed an approach that protects Hutch team formed a strong bond. “I’ve had such good people blood cells by inserting an engineered gene that shields them coming and taking care of me,” said Charlie. from benzylguanine. This allowed physicians to “take the gloves off” and use benzylguanine to beat back the cancer with more force than ever before. Four years later, Charlie is cancer free. Six other patients who have received Kiem’s treatment have not shared Charlie’s miracle, but their lives were extended well beyond other glioblastoma patients. It’s been a long road for Charlie and his wife Elaine, but finally that sense of relaxation they last felt together on that fateful Fourth of July is back. “A little over a year ago, I allowed myself to think for the first time that the cancer is really gone,’” Elaine said. Kiem, who draws inspiration from Charlie’s story, continues to enroll patients in this small clinical trial. “This is why I do medicine,” said Kiem. n Dr. Hans-Peter Kiem holds the José Carreras/E. Donnall Thomas Endowed Chair for Cancer Research at Fred Hutch, which was established with a generous contribution from the Friends of José Carreras International Leukemia Foundation and gifts from Fred Hutch faculty and staff. C HAR LI E A N D H I S W I F E EL A IN E A RE J UST B EG IN N IN G TO BELIEVE THAT C H A R L I E’ S BR A I N CA N CER IS GO N E. Photo by Matt Hagen 9 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T B O N E M A R R OW T R A N SPL A N T SURV IVO RS GATHER AT FR ED H U TCH FOR TH E LEGACY FOR LIFE CELEBR ATION IN 2011. Photo by Jim Linna M i l e s t o ne mea n s h u n dreds o f t ho us ands cu re d wi th H u tch sci ence L ast year, doctors performed the world’s one millionth a growing number of other diseases, including Crohn’s bone marrow transplant – a staggering illustration disease and HIV. of how Fred Hutchinson Cancer Research Center breakthroughs revolutionize cancer treatment and save lives worldwide. Led by Dr. E. Donnall Thomas, the Center’s scientists Dr. George McDonald and his colleagues recently opened a clinical trial that looks at whether transplants can eradicate severe Crohn’s disease, an inflammatory bowel disease that occurs when an abnormal immune pioneered the procedure and have spent decades system reacts to bacteria that have penetrated the refining and improving it as a curative treatment for lining of the gastrointestinal tract. McDonald’s research blood disorders, including leukemia. Now, Fred Hutch builds on a serendipitous discovery: When patients with researchers are at the forefront of investigating how bone leukemia and Crohn’s disease underwent transplants marrow transplantation can be extended to help treat C O N T I N U E D N E X T PAG E > 10 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T to treat their cancer, the procedure wiped out their Crohn’s teaming up with private organizations and individuals to disease for as long as 15 years. extend bone marrow transplantation’s lifesaving power, Drs. McDonald made that observation in the 1990s, but balked at using transplants on Crohn’s patients because the procedure was too dangerous to be applied to a disease that wasn’t life-threatening. Then Fred Hutch’s Dr. Rainer Storb developed reduced-intensity transplants that Keith Jerome and Hans-Peter Kiem are investigating how the procedure can lead to new treatments for patients with HIV/ AIDS. Jerome, of the Vaccine and Infectious Disease Division and Kiem, of the Clinical Research Division, are building on the remarkable success story of Timothy Ray Brown – the first person cured of HIV. are less toxic and result in fewer side effects. That led McDonald to rethink transplants Brown was diagnosed with the virus as a Crohn’s therapy. His new study will in 1995 and used antiretroviral therapy to examine bone marrow transplants as a control it. Then, in 2007, he received a bone potential treatment for Crohn’s patients who marrow transplant to combat acute myeloid do not have leukemia. leukemia. The cells came from a donor who carried a rare gene mutation that made the “Instead of giving massive-dose donor naturally immune to HIV. chemotherapy to kill the bone marrow, Dr. Storb’s reduced-intensity method of These transplants eradicated Brown’s transplant can suppress the immune system and let the donor bone marrow take over,” McDonald said. “It’s a different concept and it’s much safer than traditional transplants.” cancer and transferred the genetic variation DR. GEOR GE MCD ONALD OF TH E CL INICAL R ES EAR CH D IVIS ION Photo by Matt Hagen The research might not have been possible without private philanthropy. McDonald is using a grant from the Los Angelesbased Broad Foundation to build the study’s infrastructure. The funds allow him to collect blood and tissue samples and also pay for a research coordinator and a research nurse. to his immune system, curing him of both diseases. The Fred Hutch-led team, called defeatHIV, is exploring this breakthrough as a possible blueprint for new curative therapies. The goal is to take blood cells from a patient with HIV, insert genetic instructions into those cells that allow them to resist the virus, and then put the cells back into the patient. “Timothy Ray Brown was a watershed case – he showed us These two key staff members have screened more than 500 that an HIV cure is possible,” Jerome said. “That never would potential clinical trial participants and performed other key have happened without bone marrow transplantation.” n tasks related to FDA and FHCRC regulatory issues. “The Broad Foundation has been essential – they gave us Funding for Dr. George McDonald’s Crohn’s Disease seed money that we can use to generate the results we need study comes from the Broad Medical Research Program to apply for larger grants,” McDonald said. of The Broad Foundation. In another example of how Fred Hutch scientists are IMPROV EM EN TS I N BO N E MA RROW TRA N SPL A N TS HAV E A LLOWED R ES EAR CH ER S LIKE MCD ONALD TO BEGIN R ES EAR CH ING ITS A PPLI CAT I ON FO R OT H ER , I N C UR A BL E DISEASES. Photo by Matt Hagen 11 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T B E N E FAC TO R S TO R Y C . J. AND A L A N AS H TO N O F SPO K A N E, WASH., DIRECT THE IR P H ILANTH R OPY - INCLU D ING TH EIR P LANNED ESTATE GIFT - IN T HE M OST FO C U S E D A N D LON G - L ASTIN G WAY PO SSIB L E. Photo by Shane Young A p re c i se a pproa ch ma ximizes t he im pact A lan and C.J. Ashton of Spokane, Wash. have been Since retiring three years ago, Alan and C.J. can think supporters of Fred Hutchinson Cancer Research more strategically about their legacy and how to maximize Center for more than 20 years. As the couple planned their the impact of their giving. In addition to supporting Fred retirement, they decided to make a significant and long-lasting Hutch, they have also volunteered their time at hospice and commitment with a gift in their will. community-based assistance programs to help those in need. “We have always believed very strongly in giving our time and money to worthwhile causes, and Fred Hutch has been at the top of our list for a long time,” Alan said. 12 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T C O N T I N U E D N E X T PAG E > “For a research center such as Fred Hutch, there is a need for different sources of revenue. We like feeling that we are fitting in, like pieces of a puzzle that includes private sources in addition to government grants.” ALAN AN D C . J. ASH TO N HAV E G IV EN TO F RED HUTCH F O R 20 YEAR S . Photo by Shane Young And at a Spokane hospital, the couple performs administrative work so medical staff can focus on caring for patients. “It’s been very rewarding,” Alan said. Behind their generosity is a precise – Alan Ashton that includes private sources in addition to government grants,” Alan said. Fred Hutch is equally strategic with the private support it receives. Scientists can quickly leverage planned gifts into government grants that are approach designed to maximize the often 10 or even 100-times larger impact of their giving. This is one reason than the original private investment. that Alan and C.J. have chosen to Together, Fred Hutch and likeminded include Fred Hutch in their will with an partners can do more in the fight estate gift, which can be optimized to fit against cancer than otherwise possible. a benefactor’s specific circumstances while helping Fred Hutch plan for the future. “For a research center such as Fred Hutch, there is a need for different sources of revenue. We like feeling that we are fitting in, like pieces of a puzzle 13 “For us, the connection is how personally affected we are by family and friends who have had cancer,” Alan said. As a prostate cancer survivor himself, Alan knows firsthand how research can impact patients and families. F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T “Our desire is to support cancer research as a broad-based approach to understanding the disease,” Alan said. “And Fred Hutch has such a wellrounded approach. They aren’t looking at just genetics or the environment, but anything and everything that could contribute to understanding the various causes of cancer and the development of effective treatments for those who are affected.” n D RS . A DA M H UG H E S, L EF T, A N D DA N G OTTSCHL IN G US ED A NEW AP P R OACH TO R ES EAR CH ING CELLU LAR BIOLOGY – AN D M A DE A N I M P O RTA N T F IN DIN G IN AGIN G RESEA RCH . Photo by Matt Hagen Re s e archers sta rt a t beginning, d i sco ve r g en esi s of a ging A fter a decade of closely examining yeast cells, last year Dr. Dan Gottschling published one of the most important recent discoveries in the field of aging research. But the breakthrough was only possible thanks to development of new technology, a willingness to cast aside old assumptions, a long-term commitment from Last year, Gottschling and Dr. Adam Hughes published their finding that links the onset of the aging process in simple brewer’s yeast – the model system that Gottschling and others use to provide clues to human diseases – to a metabolic change in the microscopic sacs in cells that store nutrients. The pair used special screening philanthropic supporters and a talented postdoc with a “nose for research.” 14 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T C O N T I N U E D N E X T PAG E > technology developed by Gottschling to determine that when acidity levels dropped in cell components known as vacuoles, another vital component of cells called mitochondria – the source of energy within cells – began to deteriorate. These were essentially the first dominos to fall in the process of aging, a phenomenon Gottschling is studying to unearth the mechanisms underlying age-related diseases such as cancer and some degenerative conditions. It was a significant finding for Gottschling and for Hughes, who was attracted to Fred Hutchinson Cancer Research Center four years ago specifically to work with Gottschling. Like so many discoveries in basic sciences, the findings required years of research. But one key event that made it all possible was the scientists’ decision to cast aside a long-held assumption in aging research: that mitochondria deteriorate over time due to their chemical reaction with molecules containing oxygen. DAN GOTTS CH LING OF TH E BAS IC S CIENCES D IVIS ION Photo by Matt Hagen “We eschewed this idea and decided to let the cells tell us what was going on,” Gottschling said. “As a geneticist, this “We eschewed this idea and decided to let the cells tell us what was going on.” – Dan Gottschling Taking their discovery a step further, the two scientists were able to extend the life of yeast cells and maintain ideal acidity levels within vacuoles by reducing their nutrient intake. This observation may help explain why some species, including mammals, live longer when calorie levels are restricted. The discovery’s clinical potential lies within monitoring the process on a grander scale, which could help scientists gauge where patients are in the aging process, meant doing experiments in an unbiased manner. This is what led us to the discovery of the role of the vacuole in causing the mitochondrial defect with age in yeast.” This approach, and how diseases like dementia and cancer develop. “There is still plenty of room for more discovery,” Gottschling said. n and developing new technology to measure changes in the cell, allowed the two scientists to make their discovery. Gottschling believes basic sciences research, which yields many insights for treatment advances, can thrive only in an environment like Fred Hutch, where its value is understood and supporters invest in it over the long-term. But the Fred Hutch’s Basic Sciences Endowment – which breakthrough was also made possible thanks to scientific provides a reliable source of funding for fundamental talent, and Gottschling credits Hughes for taking a fresh research like Gottschling’s – was established in 2011 approach to the research and for painstakingly studying and through a generous anonymous estate gift and has analyzing results. been supported by numerous benefactors, including Karl and Carol Ege. 15 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T trials program using the pancreas cancer model he developed. That model, which has become the standard for studying the disease, led Hingorani to discover that pancreas tumors encase themselves in a fibrous tissue that deflects chemotherapy. Encouraged by these results, the foundation has continued to support Dr. Hingorani’s research. “This type of work is not possible unless you have a partner like the Mead Foundation willing to take the big risk with you in return for the possibility of a big gain in terms of impacting human suffering,” Hingorani said. “They have really enabled us to try some ideas that we felt very D R. SUN I L H I N G OR AN I IN HIS F RED HUTCH L A B . Photo by Stephanie Felix A dva nci n g h ope i n th e f i gh t a g a i n st p a ncre a ti c ca n cer strongly about but were very different from conventional approaches and therefore difficult to get supported through traditional sources.” Calder M. Mackay, president of the Giles W. and Elise G. Mead Foundation, said his organization hasn’t limited its funding to any specific lines of inquiry, which has allowed Hingorani’s lab to apply it in the most effective and flexible A ways possible. Hutchinson Cancer Research Center’s annual report – is connected with this work that is advancing against such a advancing through clinical trials and continuing to offer deadly cancer,” Mackay said. n n innovative approach to treating pancreatic cancer – a discovery detailed last year in Fred “The directors of the Foundation are very proud to be hope to patients with few treatment options. In June, Dr. Sunil Hingorani delivered promising results from a Phase 1b clinical trial at the annual meeting of the American Society of Clinical Oncology. He reported that the trial confirmed that an experimental combination of chemotherapy and a special enzyme known as PEGPH20, designed to help deliver chemotherapy into pancreas tumors, could in fact be administered in safe doses. Participants are now being enrolled in a randomized Phase 2 clinical study, which will determine the effectiveness of the combination treatment. With luck, the trial will show that the enzyme and chemotherapy together do effectively fight pancreas cancer. LAB P R OGR AM MANAGER S H ELLEY TH OR S EN, LEFT, S U NI L H INGOR ANI AND P R ES ID ENT OF GILES W. AND ELIS E G . M E A D FOU NDATION, CALD ER M. MACKAY. Photo by Matt Hagen The novel treatment approach was seeded through a partnership between Hingorani and a California-based foundation that saw the potential in his work. In 2007, the Giles W. and Elise G. Mead Foundation awarded Hingorani a three-year grant to develop a preclinical Dr. Sunil Hingorani’s advances in pancreatic cancer research are made possible in part by grants from the Giles W. and Elise G. Mead Foundation, generous gifts from David Jones and Maryanne Tagney-Jones, and the fundraising efforts of Charlene and Greg Steinhauer. 16 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T VIC E P R E SI DE N T O F IN DUSTRY REL ATIO N S A N D CL IN ICAL R ES EAR CH S U P P ORT U LR ICH MU ELLER , LEFT, INS ID E D R . STEP HE N TA P S C OT T ’ S L A B. T HE TWO A RE CO L L A B O RATIN G WITH D R U G MAKER GLAXO S MITH KLINE TO LEVER AGE TAP S COTT’S M U S C U LA R DYST R OP H Y R E SEA RCH TO DEV ELO P A TREATMEN T FOR TH E D EBILITATING D IS EAS E. Photo by Matt Hagen P h a rm a j oi n s tea m to beat mus cular dys t ro phy D r. Stephen Tapscott has labored for years at time was the company’s first agreement with a U.S.-based Fred Hutchinson Cancer Research Center to unravel institution under the company’s academic partnership the mechanisms that drive muscular dystrophy, program. The agreement is aimed at developing a condition that steadily deteriorates muscles until new therapies that can block production of the they stop functioning. FSHD-causing protein. Last year that work caught the attention of a key “GSK has huge expertise in developing agents against partner that could be critical to transforming Tapscott’s protein activity, so our opportunity to work with them is research into an effective therapy. fantastic,” Tapscott said. Although a new treatment is Understanding muscular dystrophy can be tricky, because some dystrophies are caused by more than one genetic flaw. Tapscott co-led a team that used new genome-wide technologies to overcome this hurdle and the primary goal, Tapscott said the partnership may also lead to new tools for better understanding some types of muscular dystrophy. The agreement with GSK is one of the most identify two genetic factors behind facioscapulohumeral comprehensive collaborations Fred Hutch has entered muscular dystrophy, or FSHD. Specifically, the researchers into with a drug company. Due to waning federal research found that two genetic variants, either on the same funding, it’s a partnership that will likely be increasingly chromosome or on two different chromosomes, cause important to translating Hutch science into lifesaving FSHD1 and FSHD2, respectively. treatments. “The presence of these two genetic variants in the “With GSK’s help, Stephen’s research has a better same individual causes the body to produce a toxic opportunity of being translated into a treatment that protein in skeletal muscle and that causes FSHD,” Tapscott muscular dystrophy patients currently lack,” said Ulrich said. The finding builds on previous years of collaborative Mueller, Fred Hutch’s vice president of Industry Relations research that had shed light on how the genes and and Clinical Research Support. n mechanisms behind muscular dystrophy work. The potential of this work was clear to British 17 Dr. Stephen Tapscott’s work is made possible through pharmaceutical company GlaxoSmithKline PLC. In generous support provided by the Friends of FSH December, GSK partnered with Fred Hutch, which at the Research and George Shaw. F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T B E N E FAC TO R S TO R Y S INC E H ER BO N E M A R R OW TRA N SPL A N T 2 0 YEA RS AGO, NEW YOR K JOU R NALIST LAU R A LAND R O AND H ER H U S BAND, R ICK SA LOM ON, HAVE B E C OM E SUP P O RT ERS A N D F RIEN DS O F F RED HUTCH . Photo by Pete Pin Fam i l y, f rien d s, d octors t eam up o n t he s t o ry o f her lif e T his past year, Wall Street Journal columnist Laura Landro Center, where her one chance at a cure — bone marrow traveled from her home in New York City to Seattle to mark transplantation — had been pioneered. the 20th anniversary of the bone marrow transplant that saved her life. She did not make the trip, or the much longer journey it commemorated, alone. The 2012 celebration reunited Laura with several Once at Fred Hutch, Laura’s team, augmented by doctors and nurses, supported her throughout the grueling treatment. Her mother, Beverly, who is a nurse with expertise in oncology, and a close friend were diligent caregivers. Her brother Chris members of a team that began to form shortly after she was donated the marrow for her transplant while her other brother diagnosed with chronic myeloid leukemia in 1991. Her first Art supplied platelets to keep her blood clotting properly. step had been to reach out to family, friends and journalism colleagues for help investigating treatment options and tracking down medical experts. That exhaustive, nationwide Chris, Art and their families were among those in Seattle for the anniversary party in 2012, which included an excursion to search eventually led her to Fred Hutchinson Cancer Research 18 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T C O N T I N U E D N E X T PAG E > “Once you have a relationship with someplace like the Hutch, you don’t want to lose it. Ever.” – Laura Landro Mount Rainier. The dominating peak has L AU R A L A N D R O I N H E R N E W YO R K A PA R T M E N T. Photo by Pete Pin “I felt so honored to be there and research. Supporting research, they say, become a totem of the team’s success especially gratified to see Rainer is a way to give back for all they have in overcoming Laura’s cancer, and the recognized,” Laura said. “He is such received. group, particularly Laura’s nieces and a pioneer, with Don Thomas, in this nephew, delighted in the opportunity to amazing treatment.” build snowmen in June. Also present for the snowy gathering Over the years, through Laura’s Laura also gives back in her professional life. After her transplant, her journalism training spurred her treatment successes and setbacks, to share what she had learned as a was Laura’s husband, Rick Salomon. Rainer has become more than just a cancer patient so others might benefit. Since meeting Laura after her transplant, trusted doctor. He and his wife, fellow She wrote essays and her book, and Rick has been by her side through every Fred Hutch researcher Dr. Beverly she traded in the Hollywood beat at check-up, two recurrences and the Torok-Storb, have forged a special bond The Wall Street Journal for a column months she spent reliving every detail with Laura and Rick, finding common she conceived, and continues to write, to write a book about her experience, ground in their no-nonsense approach called “The Informed Patient.” In it she “Survivor: Taking Control of Your Fight to life and their tastes in wine — Rick covers news that helps readers better Against Cancer.” and Beverly prefer reds while Laura and navigate the health care system. He was by her side again in December 2012 when the couple Rainer enjoy whites. As a well-known journalist, Laura is Rick and Laura have also become frequently contacted by other cancer returned to Seattle, this time to publicly steadfast friends of Fred Hutch. “Once patients seeking guidance. When your honor another team member who had you have a relationship with someplace health is at stake, she said, “You call in been instrumental in Laura’s cure, her like the Hutch,” Laura said, “You don’t every chip you have, but sometimes physician, Dr. Rainer Storb. During want to lose it. Ever.” it’s hard to get connected to the right an emotional evening at the Hutch Holiday Gala, Laura and Rick stood with Rainer on stage, representatives of the partnerships that make transplantation and other cancer breakthroughs possible. One way she and Rick remain so connected is by directly funding research. His expertise in investment management and philanthropy, and their shared appreciation for the lifesaving power of Fred Hutch science, led them to establish an endowment for leukemia 19 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T people.” Knowing how critical her network of supporters has been, Laura now finds it gratifying to be able to direct others to resources they can use to assemble their own teams — teams that may one day gather to celebrate more joyful milestones. n CA P E TOW N , S O UT H A F RICA WIL L SO O N B ECO ME A N IMP ORTANT LOCATION IN FR ED H U TCH ’S EFFORT TO STOP THE G LOBA L S P R E A D O F HIV. H ut ch Ca pe Town l a b accelerat es vaccine w o rk I n Cape Town, South Africa, Fred Hutchinson Cancer own research. This new lab illustrates how Fred Hutch is Research Center staff have spent the past year building constantly seeding new, international collaborations that a state-of-the-art lab that will be one of Africa’s most bring researchers together to take on some of the world’s advanced scientific facilities. most pressing health challenges. The lab will play a critical role in the quest to find a “We wanted to test the vaccines in a place where vaccine that ends HIV’s deadly march. It will analyze they could have the biggest benefit, and we needed the results from upcoming trials of innovative new HIV infrastructure to do that without shipping samples all vaccines and will help African scientists advance their the way back to Seattle,” said Dr. Julie McElrath, a Hutch C O N T I N U E D N E X T PAG E > 20 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T D R. JU L I E M C E L R AT H , S ECO N D F RO M L EF T, IN SIDE A L A B I N FR ED H U TCH ’S VACCINE AND INFECTIOU S D IS EAS E D IVIS ION. MCE LR AT H I S PR IN C IPA L I N V EST I GATOR O F THE HUTCH’S HIV VACCIN E TR IALS U NIT, PART OF H VTN, TH E WOR LD’S LAR GEST H IV TR IALS P R OG R A M . Photo by Matt Hagen senior vice president who is director of Fred Hutch’s Vaccine to launch smaller, more targeted trials that try to quickly zero in and Infectious Disease Division and directs the Hutch’s HIV on an effective vaccine. Vaccine Trials Network’s Laboratory Center. Headquartered on Fred Hutch’s Seattle campus, the HVTN “If we get the right results, we could potentially make the vaccine far more effective in a relatively short period of time,” is the world’s largest network dedicated to testing vaccine said Dr. Larry Corey, Fred Hutch’s president and director and candidates for the prevention of HIV. The upcoming South HVTN principal investigator. Corey launched HVTN in 1999. Africa trials will test new and improved versions of vaccines which, in a trial conducted in Thailand, were shown to reduce the rate of HIV infection by about The project received critical funding from the Bill & Melinda Gates Foundation and represents a partnership between Fred Hutch and South Africa’s research 30 percent—the most promising community. The lab will collaborate HIV vaccine result to date. with local researchers and aim to HVTN staff have spent the increase the country’s scientific past two years fanning out across capacity in the fight against HIV, southern Africa, scouting trial sites said Dr. Erica Andersen-Nissen, and laying the foundation for trials director of the lab. that will involve roughly two dozen “That’s a really important goal new sites and several thousand – to partner with African scientists patients. Phase 1 studies are and clinicians to lay a foundation for already taking place to make sure the vaccines are safe. The goal is to launch a large Phase 3 trial – research that extends far beyond THE EX TERIO R O F TH E NEW CAP E TOW N H VTN IMMUN O LO GY L A BOR ATORY. the HVTN,” she said. n which confirms effectiveness and determines any side effects – in 2015. The lab will analyze blood samples from trial participants The HIV Vaccine Trials Network is supported through a cooperative agreement with the National Institute to see how their immune systems react to the vaccine and of Allergy and Infectious Diseases. The renovation of interact with the virus. If the trial confirms the Thai trial’s the Cape Town HVTN Immunology Laboratory is made results, researchers may learn which responses future possible through generous support provided by the vaccines should aim to produce. That would position scientists Bill & Melinda Gates Foundation. 21 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T A DEDI CAT ED C OH O RT O F PRO STATE CA N CER STUDY PARTICIPANTS , INCLU D ING JIM KIEFERT OF OLYMP IA, WAS H ., HAS M A DE DR . JA N E T STA N F O RD’S RESEA RCH PO SSIBLE. Photo by Matt Hagen Te am re sea rch yi el d s new co nnect io ns , h o p e f o r prosta te ca n c er. F or many prostate cancer patients, there is a window of opportunity following diagnosis when cancer’s This year, Stanford, who co-directs Fred Hutch’s Prostate Cancer Research Program, published her finding progression or recurrence may be stymied. Dr. Janet that cholesterol-reducing medications called statins Stanford’s latest research targets this window by significantly reduce prostate cancer mortality. The study evaluating the re-purposing of a popular and seemingly was conducted in collaboration with a researcher from unrelated type of medication. C O N T I N U E D N E X T PAG E > 22 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T “This study represents an important partnership between researchers, patients and donors, all of whom are critical to the successful completion of this discovery aimed at reducing prostate cancer morbidity and mortality.” – Janet Stanford Maastricht University in the Netherlands. Funding support D R . JANET STANFOR D OF TH E P U BLIC H EALTH S CIENC E S D I V I S I ON Photo by Matt Hagen “This study represents an important partnership between was provided by the Dutch Cancer Society, the National researchers, patients and donors, all of whom are critical Cancer Institute, Fred Hutch’s own Innovators Network, and a to the successful completion of this discovery aimed at Creativity Award presented to Stanford by the Prostate Cancer reducing prostate cancer morbidity and mortality,” Stanford Foundation in Santa Monica, Calif. said. One such partner is Jim Kiefert, a retired school district The discovery could have broad impact as prostate cancer is the most common type of malignancy and the second leading cause of cancer-related deaths in men, and more than a quarter of all men in the U.S. take a statin to reduce their cholesterol level. “My hope is that this work will stimulate further research on the potential role that statins may play in reducing prostate cancer-specific mortality, which accounts for almost 30,000 cancer-related deaths a year in the U.S. alone,” Stanford said. administrator and current chairman of the Pacific Northwest Prostate Cancer SPORE, a consortium of four regional research institutions. Kiefert has also facilitated a cancer support group for about 20 years. Stanford said it seems unlikely that federal research funders would support a large randomized trial on the topic given the current budget constraints, but she hopes other researchers with access to data on statin use among prostate cancer patients will further test the hypothesis set forth by her work. n “If such medications are confirmed to reduce the risk of fatal prostate cancer, then that would offer hope to many of the almost 240,000 U.S. men each year who are diagnosed with the disease.” Importantly, Stanford said, this research has relied on the The research of Dr. Janet Stanford is supported in part participation of hundreds of Seattle-area men whose data and by Fred Hutch’s Innovators Network, a group of indi- biospecimens have become a critical resource in support of viduals whose aggregate funding through the Hartwell various prostate cancer research efforts underway Innovation Fund seeds advances in all areas of the at Fred Hutch. 23 Hutch’s research. F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T B E N E FAC TO R S TO R Y LY NN LI P P ERT, L E F T, A N D SA L J EPSO N B O N DED OV ER THE IR LOVE OF MOU NTAIN CLIMBING AND S H AR E A COMMITMENT TO SU PPORT I NG B RE AST CA N C E R R ESEA R CH AT F RED HUTCH. Photo by Leah Nash Su rv i vo r, pa rtn er ma ke ho pe and s urvival t heir lives’ w or k A t 71 years old, Lynn Lippert has climbed so many mountains she’s lost track of them all. But she remembers Lynn grew up hiking with her brothers in Oregon. It wasn’t until college where she trained to become a physical therapist every summit she’s topped to raise funds for Fred Hutchinson that she began summiting peaks, starting with Mt. Hood Cancer Research Center’s Climb to Fight Breast Cancer. outside of Portland. Over the next 50 years, Lynn’s passion for Lynn remembers them in part because she always carries a banner with the names of more than 1,000 people touched by cancer – in celebration of their survival or their memories. climbing led her across the western United States, Ecuador, Nepal and Africa. While working as a physical therapy teacher, Lynn met avid There are so many names she’s had to add an extra panel. “It’s climber Sal Jepson. The two became climbing partners and a symbol that there’s just way too much cancer in the world,” soon life partners. Sal’s support would be critical to helping Lynn said of the banner. Lynn overcome her greatest obstacle. But it’s also a symbol of hope, which is something the three-time cancer survivor knows a lot about. 24 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T C O N T I N U E D N E X T PAG E > Since then, she has topped 15 more mountains, the most recent one – Mt. Olympus in Washington state – on her 71st birthday. Over the course of her climbs, she has raised more than $200,000 for the cause. The commitment to cancer research, and the incredible amount of support that Lynn has received through the Climb to Fight Breast Cancer, left a permanent impression on her and Sal. In August 2012 the couple established a $50,000 endowment to support breast cancer research at Fred Hutch. A year E VE RY M OUN TA I N T H AT LYN N HAS SCA L ED F O R THE CL IM B, S H E H AS CAR R IED A BANNER B E AR IN G T H E N A M E S O F PEO PL E SHE HAS MET WHO HAV E BEEN TOU CH ED BY CANCER . THE B AN N E R N OW H AS MO RE THA N 1 ,0 0 0 N A MES. Photo by Colin Stapp later, they added another $50,000 to their fund. Sal said she and Lynn live the way they do so they can make the kind In 1997, as Sal was going back to diagnosis, the pair took a year off and school to start a second career as traveled around the world, a trip that a veterinarian, Lynn was diagnosed included summiting Mt. Kilimanjaro, with breast cancer after a routine Africa’s highest peak. annual mammogram. She underwent a lumpectomy, radiation and chemotherapy treatment, a regimen that seemed to work. But in 2000, Lynn’s doctor discovered a tumor in her other breast during another mammogram. She opted for a double mastectomy to remove the tumor and reduce the risk of future cancer. The strategy was effective for several years, but in 2009 Lynn experienced pain in her pelvis and an examination showed that the “Almost a year to the day from my last chemo treatment, we were standing on the summit of Kili,” Lynn said. “That was a very sweet and emotional moment. Coming down, I felt like I was getting on with my life.” Sal believes Lynn’s unwillingness to with the Hutch pilot projects, which need funding but aren’t quite ready for large National Institutes of Health grants,” Sal said. “We truly believe one of those brilliant researchers will be the one to make a breakthrough and find a cure.” n “Lynn has a very powerful story to have a wonderful life in spite of cancer,” to stop its growth and reverse it into Sal said. “I think her story is compelling remission, where it remains today. to those who have the diagnosis and think life is over. It’s not over until it’s over.” It was Sal who first learned about focused on the positive and remained the Climb to Fight Breast Cancer and committed to enjoying life. The couple thought it was the perfect outlet for took a trip to Hawaii after Lynn’s first Lynn. In 2005, Lynn completed her first bout with cancer. After her second Climb to Fight Breast Cancer peak. 25 a cure and are impressed and intrigued diagnoses and a recurrence. Fortunately, Lynn caught it early enough the two stayed hopeful, kept active, “We have a vested interest in finding stay strong in spite of two primary tumor cancer had metastasized in her bones. Sal closer together. During each ordeal, cancer research. let cancer dictate her life allowed her to show you can thrive and survive and Lynn’s diagnoses brought her and of commitments they have to breast F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T LYNN LIP P ERT ON MT. H OOD. Photo by Colin Stapp D R. UL R I K E “ R I K I ” P ETERS L EA DS A REGUL A R MEETIN G FOR LOCAL MEMBER S OF TH E GENETICS AND EP ID EMIOLOGY OF C OLOR E C TA L CA N C ER C O N SO RT I U M. Photo by Matt Hagen A rm y o f d etecti ves d i s co ver c o l o n ca n cer’s g en eti c clues S ifting through millions of genomes to find genetic cancer. Although colonoscopies are an effective screening clues as to why some people face a greater risk of tool, understanding exactly who is at the greatest risk of colorectal cancer requires a team approach. In fact, it colorectal cancer can help physicians determine more requires a small army. precisely when to request a colonoscopy and how often it That’s why scores of should be performed. researchers from Fred Hutch and 40 other institutions With the continued around the world have joined development of faster, less forces. Co-led by Drs. Ulrike expensive DNA sequencing “Riki” Peters and Li Hsu at technologies, Peters said Fred Hutch, the group recently knowledge gleaned from studies identified variations in four like hers will have increasing genes linked to an increased risk of colorectal cancer. The four genes – NABP, value as more and more of CO N SO RTIUM MEMBER S INS ID E TH E AR NOLD BU ILD ING ATRIUM O N THE FR ED H U TCH CAMP U S Photo by Matt Hagen the population’s genomes are sequenced. LAMC1, CCND2 and TBX3 – were not previously Peters and colleagues plan to build upon their associated with colorectal cancer, and Peters and discovery. Further study could yield hundreds more colleagues found variations among them can increase genetic variations linked to colon cancer risk. cancer risk by 10 to 40 percent. The study drew from some 40,000 samples collected “We want to bring in more partners. We will need to get bigger and bigger and will bring in about 40,000 and evaluated by the Genetics and Epidemiology more samples as part of our ongoing research. That’s an of Colorectal Cancer Consortium. The consortium’s important way we can understand more about the genetic coordinating center is housed at Fred Hutch and Peters is risk factors for colorectal cancer,” Peters said. n its principal investigator. The discovery could lead to new drug targets, or even help identify people at increased risk of colorectal 26 Dr. Ulrike Peters’ research was made possible in part by support from the Nelda Kleinschmidt Estate. F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T DR . P ET ER N E L S O N IN HIS L A B O F THE HUMA N B IO LOGY D IVIS ION. Photo by Dean Forbes Hu t ch l ea d s ch a rg e that unco vers chemo res is t anc e R esistance to chemotherapy is almost as frustrating for cancer rather than more generic vulnerabilities, such oncologists as it is heartbreaking for cancer patients. as damaging DNA,” Nelson said. “Our findings indicate Thanks to a breakthrough by a team of scientists led by Fred Hutchinson Cancer Research Center, science is a significant step closer to understanding why that the tumor microenvironment also can influence the success or failure of these more precise therapies.” The collaboration of scientists included researchers chemotherapy fails to wipe out all of the tumor cells from the University of Washington, Oregon Health & it targets. Sciences University, the Novato, Calif.-based Buck The multi-center collaborative study, led by principal investigator Dr. Peter Nelson, determined that a normal, healthy cell found in connective tissue surrounding the Institute for Research on Aging and the Lawrence Berkeley National Laboratory in Washington, D.C. “This study is an example of collaborative, translational tumor cells, the fibroblast, sustains DNA damage when research that capitalizes on years of federally funded exposed to chemotherapy. As a result of that damage, investments into the development of tissue banks and fibroblasts crank out a protein called WNT16B, which clinical trials in which we were able to track long-term actually enables cancer growth and resistance to therapy. patient outcomes. Investing in this type of infrastructure is Nelson and colleagues analyzed tissue samples from patients who underwent chemotherapy for prostate, critical but may take many years to see payoff,” Nelson said. n breast or ovarian cancer. Their findings underscore the complexity of the microenvironment, or “neighborhood” in which cancer cells live and how changes in that environment impact cancer growth. Their findings also suggests that identifying a way to block fibroblast response to chemotherapy may improve treatment effectiveness. “Cancer therapies are increasingly evolving to be very specific, targeting key molecular engines that drive the Dr. Peter Nelson’s research is made possible in part through support provided by David & Doreen Keyes Foundation, the Canary Foundation and the Prostate Cancer Foundation. 27 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T B E N E FAC TO R S TO R Y GARY A N D CAT H E R I N E BYLUN D SUPPO RT SEV ERA L F RED H U TCH R ES EAR CH ER S , INCLU D ING D R S . S U NIL H INGOR ANI, MAR K R OT H A ND B O NN IE M C G R E G O R . Photo by Matt Hagen C o up l e t u rn s con n ecti ons int o lifelo ng bo nd F or Gary and Catherine Bylund, supporting Fred Hutchinson experimental treatment. But soon Catherine noticed a shift. Cancer Research Center is all about personal connections: Fewer families were coming to the funeral home. not just the family links through which they were introduced to the organization, but the relationships they have since developed, especially with scientists. Through these relationships, the Bylunds have become personally invested in the innovative research they fuel with their contributions. Catherine’s first, very personal encounter with Fred Hutch came long before she met Gary, when researchers were still pioneering bone marrow transplantation as a cure for blood cancers. She worked at a nearby funeral home where she met “I saw the outcomes [of transplantation] change and change very dramatically in a very short amount of time. I knew something exciting was going on in Seattle.” Catherine said. Gary, meanwhile, had become a Fred Hutch supporter through his first wife, Jackie, and her family’s annual Fourth of July celebration known as the Sign of the Orz. What started in 1969 as a simple family gathering — with an auction added families of patients who had died despite receiving the then28 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T C O N T I N U E D N E X T PAG E > to keep everyone entertained between lunch and dinner — quickly grew into an impressive fundraiser for local organizations. Fred Hutch was among the first beneficiaries the family chose to support. When Jackie died suddenly in 2005, Gary and the family made sure the tradition continued. Today, Gary and Catherine still host the event, bringing together hundreds of family THE BYLUND FAMILY’S FOU RTH OF JU LY PARTY AND FR ED H U TCH FU ND R AIS E R I S K NOWN AS “ THE SIGN OF TH E OR Z.” Photo by Matt Hagen members and friends and raising tens of thousands of dollars for Fred Hutch research each year. Those original ties have since multiplied thanks to Gary and Catherine’s thoughtful engagement with Fred Hutch. As charter members of the President’s Circle, for example, they have found many opportunities to interact with others who share their team and learning more about their to qualify for a federal grant. They hit breakthroughs. upon the idea of crowdfunding — a Gary, in turn, has been drawn to Dr. Mark Roth’s work on suspended animation, which could buy time for heart attack and trauma victims as well as other critically ill patients. Having lost his first wife to a cause that may “It’s truly a community,” Catherine said. “There’s a symbiotic relationship between the scientists and the donors. We’ve connected with a number of scientists and are following their stories and successes. That, for me, has forged a lifelong relationship with the Hutch.” One such scientist is Dr. Sunil Hingorani. The story of Sunil’s quest to cure pancreatic cancer, the particularly deadly disease that killed his father, struck a chord with Catherine, whose uncle died of the same malignancy. After hearing Sunil present his research, Catherine chose to spend her 50th birthday touring his lab, meeting his 29 individuals to pool donations, usually via the Internet, to support a defined project. “Sounds like something we should do at the Hutch,” Gary told Bonnie. “It could be a new vehicle for funding “There’s a symbiotic relationship between the scientists and the donors. We’ve connected with a number of scientists and are following their stories and successes. That, for me, has forged a lifelong relationship with the Hutch.” – Catherine Bylund passion for lifesaving research. mechanism that enables networks of one day be survivable with the help of Mark’s approach, Gary knows well the potential impact of the work. “It will be one of those game-changing discoveries,” he said. More recently, Gary met another visionary researcher, and what began as an impromptu discussion sparked a whole new experiment: Fred Hutch’s first crowdfunding campaign. When Gary first talked with Dr. Bonnie McGregor, he was immediately struck by her passion for her latest project, developing and testing a web-based program to support ovarian cancer survivors. But he also recognized Bonnie’s apprehension about obtaining funding for work that was too novel F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T start-up thoughts and projects.” So, with Gary’s encouragement and a generous pledge to help catalyze the effort, they set out to test the idea. Bonnie launched her campaign on Indiegogo.com in May 2013, and in 40 days her crowd, including the Bylunds, raised more than $12,000, surpassing her original goal of $10,000. Creating opportunities for more people to connect with Fred Hutch — whether through holiday celebrations with family and friends or the power of online networks — seems to be a natural byproduct of the thrill Gary and Catherine get from being so closely intertwined with the research. “We’re in this fight together,” Catherine said. “I really like that. I can wrap my arms around it and get behind it.” n M E S S AG E F R O M D O U G WA L K E R , B OA R D O F T R U S T E E S C H A I R , F I S C A L Y E A R 2 0 1 3 D O U G WA L K E R W i t ho ut yo ur s uppo rt , t here would be no lifes aving advanc e s Cancer is a problem we must overcome together. That’s why Fred Hutchinson Cancer Research Center has built a collaborative research environment that enables our scientists to pursue innovative approaches in medical research. This approach has attracted some of the world’s brightest minds to Fred Hutch. These brilliant minds have made huge advances in preventing, detecting and treating cancer and other diseases. We need people like you who share our extraordinary vision of eliminating cancer and other life-threatening diseases. Medical research can only go so far without clinical trial participants, volunteers and benefactors whose contributions empower our scientists to push the boundaries of research and save more lives. Without your support, there would be no lifesaving advances. Fred Hutch is poised to make great advances in research fields such as immunotherapy, HIV, muscular dystrophy and several kinds of cancers. Your support not only allows us to conduct entrepreneurial science that no health agency or drug company would fund, but also helps our discoveries realize their lifesaving potential. This is our fight to win. With your help, we can end cancer together. 30 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T ENDI N G CA NCER TO GET HER P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Fred Hutchinson Cancer Research Center relies on private contributions to accelerate scientific advances. This crucial support aids in the pursuit of novel ideas, sustains promising research and enables scientists to explore new directions as they emerge; all paramount in the fight against cancer and related diseases. We are grateful to each of the 19,755 benefactors who provided $24.1 million in contributions and in-kind gifts between July 1, 2012 and June 30, 2013. Each of the individuals, corporations, foundations and organizations listed below contributed $1,000 or more within the 2013 fiscal year. We are grateful for the generous investment from all of our supporters in our relentless pursuit to improve the prevention, detection and treatment of cancer and related diseases. Nobel Laureates Circle Bill and Melinda Gates St. Baldrick’s Foundation W. M. Keck Foundation The Nobel Laureates Circle recognizes Bob and Eileen Gilman Family Susan G. Komen for the Cure Doug and Maggie Walker benefactors who have made cumulative David and Patricia Giuliani and Foundation Herman E. Tenzler Estate gifts of $1 million or more. These key The GM Foundation Dr. and Mrs. E. Donnall Thomas $100,000 - $249,999 contributors are permanent members of Calvin A. Gorman Trust Mikal and Lynn Thomsen Alex’s Lemonade Stand the Circle which was established to honor Alice Coulon Hanson Hazel Johnson Toly Estate Fred Hutch’s Nobel Prize recipients, John J. and Katherine A. Harnish Bonnie and Jim Towne Alfred P. Sloan Foundation Drs. E. Donnall Thomas (1990), Lee Hartwell Lee Hartwell and Theresa Naujack Hartwell Turner Construction Company Athena Partners Foundation (2001) and Linda Buck (2004). By giving at The Hearst Foundations United Way of King County Bezos family this level, members of the Nobel Laureates Bob and Pat Herbold W. M. Keck Foundation Jeff and MacKenzie Bezos Circle are at the forefront of philanthropic Arthur P. Holm Estate Elizabeth Wayner Cancer Research Institute leadership and make a significant impact Howard Hughes Medical Institute Richard W. Weiland Estate Roger and Gloria Crouch on Fred Hutch’s mission to eliminate cancer Yvonne Twining Humber Estate and related diseases as causes of human Immunex Nobel Laureates Circle membership J. Orin and Charlene Edson suffering and death. J. Orin Edson Foundation includes five anonymous benefactors. Clairmont L. & Evelyn S. Egtvedt Holly and Eric Dillon Jacob Green Charity Golf Classic Madeline and Howell E. Adams, Jr. Erna M. Jorgensen Trust Mr. Paul G. Allen José Carreras International American Cancer Society Foundation for Childhood Cancer Ellison Foundation The Ellison Medical Foundation Fiscal Year 2013 Benefactors Leukemia Foundation John and Christine Enslein Friends of FSH Research American Heart Association Nelda Kleinschmidt $1,000,000 and Up Ed and Karen Fritzky Family Amgen Leukemia & Lymphoma Society Bill & Melinda Gates Foundation The G. Harold & Leila Y. Mathers The Anderson Foundation Life Sciences Discovery Fund Howard Hughes Medical Institute Robert M. and Pattie Arnold Listwin Family Foundation Life Sciences Discovery Fund Hyundai Hope on Wheels Avon Foundation for Women LIVESTRONG LIVESTRONG Foundation J. Orin Edson Foundation Bezos family Lymphoma Research Foundation The Sloan Foundation Jacob Green Charity Golf Classic Bill & Melinda Gates Foundation Lucille P. Markey Charitable Trust Burroughs Wellcome Fund Mr. John A. 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Komen Microsoft Research Foundation Research Foundation Lupus Research Institute Ovarian Cancer Research Delta Tau Delta Fraternity Dorothy and Everett O’Neill Peter S. and Sandra W. Dyer The Paul G. Allen Family Foundation $250,000 - $499,999 The Moyer Foundation J. Orin and Charlene Edson James B. Pendleton Charitable Trust Anduin Foundation Multiple Myeloma Research Foundation Clairmont L. and Evelyn S. Egtvedt Prostate Cancer Foundation Burroughs Wellcome Fund National Breast Cancer Foundation, Inc. The Ellison Medical Foundation James and Sherry Raisbeck The Eucalyptus Foundation Carol-Ann O’Mack and John Deininger Entertainment Industry Foundation / Richard C. Goldstein Private Foundation David and Patricia Giuliani and Foundation Donna Kay Peterson Trust Jim Roberts and Pam Becker The Hope Foundation Prostate Cancer Foundation The Eucalyptus Foundation Dorlesca Hazel Ryan Estate Leukemia & Lymphoma Society RACE Charities Foundation Fannie E. Rippel Foundation Safeway Inc. 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Lowell Norman Archibald Charitable Foundation James and Roberta Weymouth Lois and Earl Dusenbery The Lupin Foundation North Mason Cancer Crusaders Mr. and Mrs. John Whetzell Jack and Sheri Edson Helen and David Mandley Northern Trust WM NC-Philanthropic Partners Expeditors International of Mattaini Family Foundation Mr. Roger F. Nyhus Woldenberg Foundation Dr. and Mrs. James Olson The Yeck Family Limei Fan and Jay Na Mr. and Mrs. Mario Mazzola Open Society Foundations Melinda Yount Dick and Nancy Farman Mr. and Mrs. Richard B. McCune Sujal and Meera Patel Richard and Janet Yulman Mrs. Harriet J. Farman Frances Evelyn McDaniel Estate The Paul M. Anderson Foundation Zillow Fashion Group International Dr. Julie McElrath and Mark and Nancy Pellegrino Joseph and Janet Zinn Dr. and Mrs. Matthew L. Fero Perkins Coie Washington, Inc. Jeff and Ethel Maxwell Dr. Kenneth D. Stuart Mr. and Mrs. David W. Findlay Matt and Carol McIlwain Fraternal Order of Eagles #1722, Merlino Fine Foods Pete and Wilma Olsen Foundation $5,000 - $9,999 Dean and Josephine Petterson Francine Horn Abrams John B. Piacentini Family Alliance Project Advisors Nelle K. Gault Estate Paul and Beth Picardo Allstate Giving Campaign Mr. and Mrs. Burke F. Gibson Miles Sand & Gravel Precision Electric Group, Inc. Alvin Goldfarb Jeweler Peter and Beth Golde Millennium Pharmaceuticals Inc. The R. B. and Ruth H. Dunn Chap and Eve Alvord Sidney and Susan Goodwill Dr. David O. Moline American Society of Hematology Grand Chapter of Washington - Natalie A. Moline Estate Charitable Foundation Renton Auxiliary Memorial Trust Ralph & Barbara Edwards Family Foundation Ron and Kimberly Andronaco James V. Ramsdell, Jr. Alan and C.J. Ashton Leonard and Joni Green Peter and Wendy Mullen Andrew and Christine Reinland AT&T Community Giving Program Mark Groudine and Cynthia Putnam Mrs. Catherine Mullin Guy Carpenter & Company, LLC M. 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Pariser Bill and Marlene Semple Jerry and Nancy Belur Mr. and Mrs. Harold W. Hill The Paul and Phyllis Fireman Seventh Avenue Associates LP Kenneth and Eileen Berkowitz Dr. Sangeeta R. Hingorani and Clay Siegall John R. and Paula Blood Family Trust Mark and Brenda Simons Blue Danube Productions Iva and Lawrence Hirsch Wayne and Christine Perry Singh Family Foundation BroadData Conferencing Mr. and Mrs. Rick Holley Plum Creek Foundation Sleep Country USA Stephen and Jennifer Brooks John H. Howard Plum Creek Doug and Marilyn Southern Mr. Aaron Bueler and Ms. Carolyn True Tamar Huberman Christina and Stephen Poore John McVickar Robinson 33 Dr. Charles Birnbach F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T San Francisco Giants Charitable Foundation Mrs. Terry Pero P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Mrs. Peggy M. Proctor Ms. Mary H. Wiese Jeff and Lisa Berkman Robert F. Butler Estate Tim and Kathy Proctor Zevenbergen Capital Investments LLC Mr. Stanley S. Berman Ms. Becky Byrd and Mr. Owen Ashurst Yahn Bernier and Beth McCaw Daniel Byrne Project Bionic Dr. Jerald Radich $1,000 - $4,999 Bessemer Trust CA, Inc. Matching Gifts Program James and Sherry Raisbeck Warren and Diana Aakervik Ken and Shiori Betzler Cafe Juanita Raman Family Foundation Garrett and Tina Abel Merrily and Doug Betzold Mr. and Mrs. Roger L. Callihan Suri and Mala Raman Ms. Susan A. Adams Mike and Jackie Bezos Camaraderie Cellars Michael and Linda Ranz Mr. Richard S. Adatto Sue Biggins Kelly Campbell REB Enterprises, Inc. Adobe Matching Gift Program Casey A. Biltucci Erica and Jose Campos Mrs. Sally Reiquam AEG Management WA, LLC Paul and Diane Birkeland Canlis Glass Residence Inn by Marriott AEK Technology, Inc. Bishop Fleet Foundation The Capital Group Companies Aero Controls, Inc. Kim Lyford Bishop Mr. Thomas F. 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Boeskov Cascade Athletic Clubs at Fisher’s Landing Jack Schenker Charitable Trust Curt and Ashley Anderson Bonaventure Senior Living Mr. Timothy Casey Mr. and Mrs. Kurt B. Schmidt Mr. Jack Anderson Mr. Michael J. Boos CBRE Charles and Mary Ann Schroeter Mrs. Karen C. Anderson Mr. and Mrs. Joseph Bordeaux Mr. David Cech Schwartz Brothers Restaurants Dr. Michael J. Anderson, DVM Joey and Jennifer Borrelli Celebrated Chefs Seattle Cancer Care Alliance Dr. and Mrs. Steven J. Anderson Ms. Catherine A. Bourdeau Mr. Theron R. Chamberlain Seattle Genetics, Inc. Andrews Commercenter Deborah Boutinen Dr. Bruce A. Chamberlin Janice and Mike Selman Mr. Robert Angel Diane E. Bowers Marsha Chandler and Pete Newman Mr. and Mrs. Ronald C. Seubert Mr. and Mrs. Jeffrey J. Antush Jim and Kathy Bowman Mr. Stephen J. Chaney Teung Shen and Johannes Thijssen Jill Argo Mr. and Mrs. Robert D. Boyd Shu-I Chang The Sign of the Orz Dr. and Mrs. Jay Arlick Ms. and Mr. Eileen T. Boyle Charlie’s Produce Woody and Karen Sillifant Mr. and Mrs. Charles G. Armstrong Brackets for Hope Chase Silver Cloud Inns & Hotels Bob and Clodagh Ash Mr. Dennis Brass Steven and Michelle Chattin SIRAS Mr. Lawrence J. Asher Mr. and Mrs. Robert R. Braun, Jr. Dr. Donald L. Chi and Mr. Jim Shobe Skanska USA Building Inc. Mr. and Ms. John K. Austenfeld Aaron Bregel Lisa Chiang The Skolnick Foundation Geoff and Catherine Austin Mr. Wayne L. Bridges, Jr. Wyman F. Chong Phil and Sally Smart, Jr. The Aven Foundation Christine L. and Michael L. Brinton Mr. and Mrs. LeRoy R. Christiansen Mr. Laurence H. Smead Mr. and Mrs. Avery Stephen and Stephani Briscombe Zita M. Chubbuck Mr. and Mrs. Brad Smith Dylan and Kalimar Avila-Petitt Bristol-Myers Squibb Company Ki-Hyun Chun Mr. and Mrs. Robert J. Smith Mr. and Mrs. Alfred A. Baffa Eric and Shelley Brodersen Gustav E. Churchill Mrs. Sandra L. C. Smith Eric Bahna Carol P. Bromel City Catering Joan and Sheldon Steier and Barbara Blywise Bainbridge Foundation Mr. and Mrs. Dean J. Brooks Claar Cellars LLC Mrs. Ritaann Stolte Thomas Baksay Mr. Michael P. Brooks Mr. and Mrs. G. A. Clark Gary and Diane Swofford Bank of Tokyo-Mitsubishi UFJ Michele Brooks Mr. J. Terence Clark Ms. Myra H. Tanita Richard and Joanne Barber Bradley and Amy Brotherton Simon Clarke and Alice Burden Paul, Pat and Siri Tift Morgan and Sarah Barbour Bill and Laura Brown Beverly C. Clayton Timbers Resort Carrie M. Barham Colleen B. Brown Deborah Cleveland Gregory and Marilyn Tompkins Gena Barker Mr. and Mrs. David A. Brown Dr. Bruce Clurman and Ms. Deb Gumbardo Warren Tressler and Merna Allen Barton Family Foundation Mr. and Mrs. Vincent J. Brunetti Mrs. Deborah B. Cohen Tulsa Community Foundation Matthew and Kerstin Bates Roger and Lynne Buckingham Coldstream Capital Management Neli Ulrich and Bruce Edgar Rowena M. Beaudry Troy and Kristin Buckley Colin Nguyen & Associates Inc. David and Shirley Urdal Linda J. Beck Charles Burdell Mr. Frank E. Colson UW Medicine Dr. Myrl E. Beck, Jr. Mr. Randal C. Burge Craig M. Colvett Nancy Greenwood Vehrs and Jeff Vehrs Arno Behr and Zelah Kahn Frank M. Burhans Estate Combined Federal Campaign of Terry and Lara Vehrs Doug Bennyhoff, Jr. and Sarah L. Bennyhoff Mr. and Mrs. Russell F. Burmester Georgia and Jeffery Vincent David and Victoria Benoliel Steve and Marlene Burns James Waddell Dr. Ronald and Cheryl Berenson Mr. and Mrs. Steve Burnstead David and Marsha Weil Dena Berg and Jessie Berg Dr. and Mrs. John D. Burroughs Wells Fargo Mr. and Mrs. George S. Berkman Mr. and Mrs. Jerry Bush Seattle Downtown Foundation 34 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Charitable Foundation Dr. Garnet Anderson San Diego County Combined Federal Campaign of South Puget Sound Combined Federal Campaign of the National Capital Area P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Combined Federal Campaign Overseas Area Mr. and Mrs. Joseph M. Dunn Chuck and Evelyn Foster Susanne and Scott Guthrie Mr. and Mrs. Richard A. Dunn, Jr. Mr. William E. Foster and Jessica Michel Hagan and Curtis Hagan Ms. Kayoko Conine Dunphy McLean, Inc. Mr. Nathaniel J. Connors Eric Durban Four Seasons Hotel Seattle Mark Hall and Rory Macfarlane Mr. Andrew C. Cook John and Marlene Durbin Ms. Susan R. Fox Steve and Karen Hall Copacino + Fujikado William and Jane Durch Fraternal Order of Eagles, Kent #362 Sajva Halverson Dr. Shannon Corbin and Todd and Virginia Dutkin Mark and Jayme Freeborn Kathryn Haniuk Pete and Phyllis Dybsand Mr. and Mrs. Frederick K. Freeman, Jr. Dave and Sandy Hanower Eva Corets and Josh Beloff Mr. Thomas R. Dyer Rachel and Rian Fried Ann Fisher Hanson Susan and Frank Countner Mrs. Amy L. Dyers Mr. Lloyd D. Frink and Ms. Janet Angell John Martin Hanson and Covidien Employee Matching Lois A. Eaden Lisa Fritzky Eastside Bridge Center, Inc Ryan L. Fritzky and Susie M. Fritzky Ryan and Eileen Harasimowicz CP Kelco Mr. and Mrs. Charles K. Ede Mr. Rodney Fujita Jeff Hardie and Laurie Saito Stephanie J. Crabtree Edith and David Altman Foundation Mr. Kyle Fukuchi Ms. Gayle R. Hardt Derron and Tammi Craft Talmage and Molly Edman Mr. and Mrs. Mort Fuller Greg Harrell-Edge Mr. and Mrs. David G. Crane Julie Edsforth and Jabe Blumenthal Chad and Jeri Dee Fullerton Harris Ford, Inc Geoffrey and Tina Croghan Jeffrey and Karen Edwards Mrs. Jacquelyn Fuzell-Casey Dr. Brian and Lyn Harris Cal and Lois Crow John and Caroline Edwards John Gadon Mrs. Judith A. Harris Barbara L. Crowe Steve Eirschele and Erin Guthrie Phil and Lisa Gafken Peter Harris Mr. and Mrs. Deane D. Cruze Allan and Peggy Elenbaas Richard and Barrie Galanti Mr. Robert M. Harris, Jr. Mr. Sylvester T. Cugini Tracey and Mike Elfstrom J. James and Margel S. Gallagher Kevin and Bobbi Harrison Jeffrey and Lorine Cummings Jerry E. and Julianne C. Elkington Dr. Denise Galloway Mr. Jason J. Harsley Esther M. Cuno John and Farida Elliott Sharon Garcia Scott and Rachel Harter Cupcake Royale Dr. and Mrs. William Ellis Mary E. Gardner Adam Hartzell Jeff and Barbara Curran Dr. and Mrs. Harley Ellman Mr. and Mrs. George F. Gauntlett Mr. O. Peder Haslestad John and Judy Curran Mr. and Mrs. Jeffrey B. Ellman, Esq. GE Foundation Peter and Pat Haug Melanie K. Curtice David and Barbara Ells Genentech, Inc. Jeffrey and Candace Havens Gerald Daily and Janet E. Freeman-Daily Steven and Marilyn Emanuel Geoffrey R. Monk Family Charitable Fund Nicole Hay Mr. Nelson J. Darling, Jr. Lynda Emel Jane Gerhardt Admiral and Mrs. Thomas Hayward Shelly P. and John DaRonche Mr. Timothy Emery Tom Gerlach and Leigh Stokes Jeff Hazeltine and Alicechandra Fritz Dave’s Killer Bread Equifax Foundation Terrence and Ellen Gibbons HCC Specialty Mr. and Mrs. Scott Davies Mr. and Mrs. Dean J. Eriksen Shelley and Lee Gill Jane Margaret Hedberg Greg Davis and Larry Besk Mr. Mark Eshom Mr. Thomas W. Gille Alexandra and Adam Hedin Mr. Mark Davison Mr. and Mrs. John L. Esposito D. Wayne and Anne E. Gittinger Bill and Joyce Hedin Bill and Wilma De Leeuw Ms. Erin L. Evans Nancy R. Giuliano Mr. and Mrs. Severt S. Hegland, Jr. James R. Degarimore Estate Jennifer Evans and Darin Kudrna Mr. and Mrs. Bradley L. 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Marshall Todd and Kate Holmes Jeanne Kanach Rae and Mark Lembersky David and Vicky Marsing Dr. and Mrs. Kenton S. Horacek Dr. Stacy R. Kanda Leonetti Cellar Martin Selig Real Estate Hotel Monaco Portland Ms. Heidi Kass Mr. and Mrs. John Lester Lauren and Jason Martin Ms. Deborah L. House Kauffman Family Foundation Phyllis Leventhal Mr. and Mrs. Peter Maslenikov Ms. Kim Howard Jim Kaufmann and Mary Thrasher Mr. and Mrs. Dan Lewandowski Ms. Marcia J. Mason Kendra A. Howe Mr. and Mrs. Isamu Kawabori Lewis River Ladies Golf Association Sue and Bill Mason Barbara J. Howell Mr. Travis J. Kay Bill and Jane Lewis Neal and Brandi Massie Mrs. Kimberly Howitt Mr. and Mrs. Thomas W. Kearns, Jr. Frank and Marianne Liebermann Master Shon Tae Kwon Do Center HTC Mrs. Nancy C. Keefe Jerrold Liebermann and Linda J. Harris MasterPark Airport Parking Brock and Dottie Hudson Mr. and Mrs. Elroy Kelzenberg Henry Liebman and Gail Katz Mr. George C. Mastrodonato and Mr. Eric J. Huffman The Kemper Freeman Foundation Mr. and Mrs. Jeremy Lince Trevor and Donabelle Huffmaster Kenco Construction Inc. Mr. and Mrs. Terron R. Lindholme Cathy Mathews Ms. Rebecca Hughes Mr. and Mrs. Daniel J. Kennedy Tom and Juli Lindquist Matthew Blend Fund Olivier and Catherine Humbert Mr. and Mrs. Robert J. Kenney, Jr. Clark and Lori Lindsay Orion and Tessa Matthews C. Dan and Irene W. Hunter KEXP 90.3 FM Mr. and Mrs. William G. Lindsay Ryan and Sara Maxwell Ms. Claudia Husemann Niraj Khanchandani Alexander C. Lindsey and Lynn M. Manley Brian and Leasa Mayer John and Bonnie Hutchinson Benjamin F. Kilgore Michael Linenberger, M.D. Mr. and Mrs. Douglas D. McBroom Scott and Amy Hutchinson Mr. and Mrs. Han Kim Mr. Harry A. Linker Tod and Christa McBryan Dr. and Mrs. William B. Hutchinson Susan Kim James Lintott and May Liang Michael D. McCann Shirley M. Hvalsoe Kimberly-Clark Foundation Lister Chain and Forge Inc Craig and Susan McCaw Hyatt Regency Indian Wells Resort and Spa Jerry and Marcia Kindinger Mr. and Mrs. Stanley M. Little, Jr. Mr. and Mrs. Jon McCormack Mr. and Mrs. William B. Hyde King Estate Winery Dr. John R. Liu and Ms. Kari Jordal Adele G. McCormick IBM Employee Services Center Suzanne C. King Don and JoEllen Loeb Ms. Alyson Mccormick IKEA Tim and Lisa Kittilsby Matt and Elisha Logue Michelle L. McCormick IMG Ms. Jean Klein Dr. Yince Loh and Ms. Kathyryn Oliver Mr. and Mrs. Jim H. McCuen Mr. and Mrs. John Inge Lynette A. Klein Mr. and Mrs. David B. Lomet Dr. and Mrs. Francis H. McCullough Mimi J. Inglin Dr. John Klippert Christi Ball Loso Matt and Wendy McCutchen Inland Northwest Community Foundation Mr. and Mrs. Douglas B. Kloke Jeffrey and Jennifer Lounsberry Mr. and Mrs. Robert D. McDonald J.CREW Mr. Larry H. Kniveton Stephen E. Lovell McDowell Family Mr. Michael Jackson and Ms. Christy Martin Mr. Phillip and Mrs. Kathleen Kolczynski Sandra Low and Christopher Flynn Anne T. McGonigle and Gregory M. Witter Jackson-Folkner Legacy Co., LLC Nora Korg Lowen Family Foundation Mr. Jeffrey McGrew Pierre and Christine Jammes KPMG LLP Dr. Michelle S. Ludwig Joan Ellen McInerney, MD FACEP Mr. and Mrs. Michael D. Janke Mark and Kathy Kralj Mr. Scott R. Ludwig Doug and Ruth McKnight Jarbo Mr. and Mrs. Michael A. and Sharon L. Kramer Claudia R. Luebbers Mark A. and Marna L. McNaughton Mr. and Ms. William M. Jenkins Mr. Kenneth J. Kreer Luly Yang Couture Mr. Robert S. McPherson David and Elisabeth Jenni Mr. Jerome L. Krell Gil and Barit Lund Medco Health Employee Giving Campaign Kurt and Clair Jensen Bruce and Therese Kroon Julie T. Lund Mr. and Mrs. Marcus Meier Jimmy Choo Mr. and Mrs. Kyle Kruse David and Deborah Lycette Menashe & Sons Jewelers Johnson & Johnson Matching Gifts Program KuKuRuZa Gourmet Popcorn Diana Lynn The Mercantile Library Allen and Carleigh Johnson Dr. and Mrs. Thomas L. Kun Lytle Enterprises LLC Mrs. Charlotte M. Merritt Brent and Catherine Johnson Mr. and Mrs. John Kuriyama The M&T Charitable Foundation Lawrence and Bernice Meurk Ms. Christine K. Johnson Richard Kyle and Kara Matthew Dennis and Vannessa Ma Mrs. Cheryl S. Meyer David and Christy Johnson Kyocera Industrial Ceramics Corporation Joan M. Mabbutt Dr. and Mrs. James G. Mhyre Elaine H. Johnson La Tavola Marche Mr. Robert Mack Mile High United Way Mr. J. Kurt Johnson Lachini Vineyards Pamela and Frank Madigan Mill Creek Sports Cards Jeffrey and Paige Johnson Molly Lallemand Ms. Jennifer Magyar Miller Nash LLP Mr. Jonathon W. Johnson Carol J. Landis Randy and Retta Main Dr. Bruce H. Miller Sherri Swingle Johnson and Matt Johnson Mr. and Mrs. Robert C. E. Laney Maison Bleue Winery John and Joyce Miller Mr. and Mrs. Stephen R. Johnson Ms. Toby C. S. Langen Behnam Malek Khosravi and Noushin Berjis Michael and Lisa Miller Mr. Paul R. Jokisch Arthur K. Langlie Mr. and Mrs. Edward J. Malley, Sr. Tammy Miller Andrea Jones Mr. Dave N. Larson Thaddeus O. Mallory, Jr. John L. Milner and Kimberly Taylor Mr. Christopher B. Jones Mr. John W. Lash Fred and Ruth Maloney Rick and Joyce Miner Dean and Stacy Jones Dr. and Mrs. James A. Laurent Steve and Janice Malos Mr. Richard L. Mitchell Rich and Aimee Jones Amy and Aaron Lavin Mr. Corwin N. Malott Mr. Phllip Moll Tyler and Anna Jones Richard and Rosemary Law Mrs. Naina A. Manji Robert P. and Lucille L. Mone Dr. S. Abraham Joseph Lawrence and Sylvia Wong Foundation, Inc. Mr. and Mrs. Raymond R. Mann Mrs. Sarah C. Moore Juniper Ridge RV Homeowners’ Association Mr. Richard B. Lawrence, Sr. Mrs. Sue L. Mann Mr. and Mrs. William R. Moore JustGive.org Robin Layton and Shakti Chen Ms. Debora B. Marcinkowski Woody Morf and Peggy Skillin Brian and Christy Kadien Kari Leal and Sandra Matteson Ms. Lisa Marcus Graham Family Foundation Mr. and Mrs. Kim J. Kaiser Christopher Leigh and Ruby D. Wilde Mr. Donald Marcy Morningside Foundation 36 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Dr. Susanne L. Gee P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Dana Morrison Mr. and Mrs. Clark M. Pennington Joan Robinett-Wilson Seattle Seahawks Mr. and Mrs. Charles H. Morse, IV PepsiCo Bruce and Diane Robinson Chris and Kristin Secreto Dr. Elahe Mostaghel The Peras Craig and Jessica Robinson Mr. Jack Seeley Motorola Mobility Foundation Drs. Carl and Jeannette Pergam Barry and Debbie Rochefort Mr. and Mrs. Ralph M. Seifert Bud Mount Dr. Steve Pergam and Kyoko Kurosawa Jason and Carol Rockhill Mr. and Mrs. Perry B. Seiffert Mr. Robert G. Mower, Jr. Pershing Rockwell Collins The Seneca Real Estate Group, Inc. Mahlon M. Moyers Dan and Stephanie Peters Anita and John Rodarte Matt and Kathy Sentena Craig and Marie Mundie Tom and Kate Peters Grant and Colleen Rodland Mr. and Mrs. Rob Sexton Mr. and Mrs. R. David Mushen Dale W. ‘Corkey’ Petersen Roman Rogalski and Diana Tattoni-Rogalski Doug and Lisa Shaeffer Dr. Tomas and Julie Mustelin Peterson Sullivan LLP Mr. and Mrs. Jeffrey J. Rogers Kabir and Noreen Shahani Dr. Geraldine Myles Donald B. Peterson and Cecilia M. Giachelli Scot F. Rogers Mr. Richard J. Shanahan Dr. Keyvan and Parvin Naficy Kemp C. Peterson Mr. and Mrs. Dennis W. Rohling Mark and Susan Shapiro National Frozen Foods Corporation Mr. and Mrs. Randal L. Peterson Mr. John Eric Rolfstad Mr. and Mrs. Frank X. Shaw Mr. and Mrs. David W. Neal Susan E. Peterson James and Jane Roll Sheedy Drayage Co. Mr. David P. Nebel Cynthia and Roger Petrie Mr. and Mrs. Kenyon B. Roll Mr. Monty Sheldon Neiman Marcus Bill and Kathy Pettit Ms. Joan Rolph Elaine C. Shepherd Ann and Stanley Nelson Mr. Alexander Piccinini James Rose Mr. and Mrs. Jonathan Sheppard Mr. Jeff Nelson Dan and Joanna Pinick Stephen and Elizabeth Rosenman Suzanne Sheppard Dr. Peter S. Nelson Mr. and Mrs. Lou Piniella Mr. and Mrs. Robert W. Rosenstock Mr. and Mrs. Ali A. Shokouhi Mr. Kurt Neuharth Mr. and Mrs. Thomas G. Piper Elizabeth E. Rosenthal Estate Valerie J. Sils Mr. and Mrs. Dennis J. Newell Pizza Viola Inc. Mr. Dan R. Roseta Mr. Lynn R. Silsbee Mr. and Mrs. Wayne E. Niemuth Michael and Heidi Plaster Brian and Kim Ross Scott E. Silver Mark and Sue Nikiel Carl and Donna Platou Mr. Donald L. Ross Mr. and Mrs. Robert L. Simeone Mr. and Mrs. Scott L. Nixon Mrs. Colleen R. Powers Calvin and Lauren Rowland Mr. Richard P. Simmons Trevor and Marci Nolan Nicole and Michael Pratapas Mr. and Mrs. Gatis N. Roze Andrew, Judith, Harriet and Tobias Sinclair Jesse and Samantha Noonan Kathleen Walker Pratt Pam and Mike Rubin The Skier Foundation Ilse Nordmann and Jorn Nordmann Richard and Melissa Pratt Scott and Susan Rusch Skillet Street Food and Events Fred Northup, Jr. and Ashley Northup Precision Genome Engineering Inc. Russell Matching Gifts Program John and Susan Skovron David Notario and Latife Lacin Elizabeth Prescott and Daniel Stetson Tom and Jeannine Ryan Mr. and Mrs. Donald C. Smaltz Novo Nordisk Pressco Products Andrew Ryder Mrs. Barbara J. Smiles Nowak Family Charitable Giving Fund Mr. Bradford A. Proctor Irada Sadykhova Mr. Scott J. Smiles Beatrice H. Nowogroski Mr. and Mrs. Peter W. Proctor Safeworks, LLC Doug Smith and Mary Templeman-Smith Heather Nunn Chris and Elissa Puckett Thomas and Terry Sager Jenna L. Smith Stephanie and Jacob Nusbaum Mr. William H. Purdy Mr. and Mrs. Gerald M. Salkowski Kelly E. Smith Obelisco Estate Ms. Cynthia Putnam Saltchuk Snohomish County Employees Michael and Esther Ochsman Robert and Victoria Quiles Mr. and Mrs. Maurice R. Samuels Mr. Daniel Ogg R & H Contractors Inc Mrs. Leslie A. Sandberg and John Okino R.D. Mushen & Associates Mr. and Mrs. John G. Olerud Ram International Co., LLC Justine and Rob Sands Mr. and Mrs. Russell J. Snyders Richard and Janet Olin Mr. and Mrs. Spencer Rascoff Mr. and Mrs. Joel R. Sarfati Soaring Heart Natural Bed Company Sarah Olin Mr. Carson A. Rasmussen Dona Sarkar Socius Law Group Mr. and Mrs. Homer J. Olsen Rich and Betty Rasmussen Perry and Melinda Satterlee Sol and Sadie Esfeld Memorial Fund of the Steven and Crystal Olsen Nicky and Jeff Razwick Mr. and Mrs. Joseph S. Saxon, Jr. Miss Elvi M. Olsson Red Carpet Valet Mr. Mike Schaefer Specialty’s Cafe & Bakery Christian and Kristin O’Meara Allison Reed Mr. Daniel P. Schafer William and Alee Spencer Sheila and Mel O’Neal Paul and Charlotte Reed David and Lisa Schilling Theodore Spitalnick and Kathleen M. Farrell Mrs. Henry L. Osterman Reformed Church in America Alexander B. Schirer Spokane Rock Products, Inc Cynthia and Thomas Ostermann Mr. Jerry Reinsdorf Chris Schlecht Joseph and Jennifer Sprague Jesse D. Ottele Lynn Scullion Reisfeld Walter and Michelle Schmetzer Ron and Mary St. Martin Robert B. Overhus Mr. Ralph A. Reisfeld, PhD Evelyn Schmidt Estate Mr. Robert W. Stafford, Jr. James T. ‘Jess’ Owen Srilata D. Remala Marj and Kevin Schmidt Staggs Coins, Baseball Cards P & A Pellarin Associates, Inc. Peter and Rhonda Resnick Schoenfeld-Gardner Foundation Pacific Metallurgical, Inc Tiffany and Casey Ribera Mr. and Mrs. William K. Schoening Pacific Wine & Spirits of Washington Maurice Rice Keith and Jennifer Schorsch Paddy Coyne’s Irish Pub Mr. and Mrs. James R. Richards Daniel R. Schroeder David Standring John Pagel and Lori Hansen Terry and Benton Richardson Patrick and Dianne Schultheis The Stanley B. & June L. Rose Foundation Mr. and Mrs. James Golden Pappas Kristen J. Richey and Joshua D. Curtis Mark Schuster Mr. Colin W. Stapp Steven W. Parmelee Dr. and Mrs. Stanley R. Riddell Mr. and Mrs. Steve Schwartz George Stathakopoulos and Nicole Miller John and Melissa Patopea Charles E. and Karen Riley Ann and Richard Scott Steeg Family Foundation Jack and Sylvia Paul Mr. and Mrs. Charles W. Riley, Jr. Steven Scott and Kristin Houser Mr. and Mrs. Robert Steeg Peak Gymnastics RJ Smith & Associates The Seattle Art Museum Mr. Seth Steinberg and Ms. Candace Kalish Franci E. Pease RMG Associates LLC Seattle Chocolate Company Mr. Brian R. Steinmetz 37 Mr. Steven Maloney F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Charitable Campaign Snoqualmie Tribe The Snow Family Foundation Jewish Federation of Greater Seattle and Collectibles The Standard Employee Giving Campaign Employee Donations P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Allyn Stellmacher and Terry Samilson UBS Matching Gift Program Mr. and Mrs. Eric J. Wiler James D. and Mary H. McClellan Aronen Kathryn Stenberg Luis and Colette Ulloa Mr. and Mrs. Richard D. Wilhelm Robert and Clodagh Ash The Stenmoe Agency Mr. Jerry E. Ulmer Brent Willems and Arleen Paulino Alan and C.J. Ashton Ms. Kathleen Stetson Umpqua Bank Associate Giving Campaign William A. Crosetto Charitable Foundation Dr. Elizabeth Atwood Stewart Title Guaranty Company Unico Properties LLC Charles and Linda Williams N. Faye Bachmeier Drs. F. Marc Stewart and Pam Becker United Way of Greater Los Angeles Jill M. Williams M. EuGene Barnes and Beverly Ann Barnes John and Genie Stewart United Way of the Quad Cities Area Paul and Barbara Williams Patricia M. Bartlett Mr. and Mrs. Michael Stewart Mr. Anthony E. Valentino Randall and Tonya Williams I. Georgina Bayley Dr. Barry L. and Amy B. Stoddard Geraldine Valentino Bart H. and Cynthia H. Wilson Ms. Diana Beckers Mr. Charles L. Stoddard Anthony and Patricia Van Ruiten Mr. Mark C. Winmill Marc A. Berger Stoel Rives LLP Danielle VanNoy Steven and Arleen Winslow Mrs. Sidonia Berglund Chuck and Jane Stonecipher Ms. Suzanne E. Vaughan Jeff and Maria Wolcott Yahn Bernier and Beth McCaw Dr. Andrew Strand James and Kallie Veeneman Mr. Robert Wolf Mr. and Mrs. Harry C. Berryman Mr. and Mrs. Marvin L. Strasburg Mr. and Mrs. James E. Veitengruber Mr. Jack W. Wood Sandra Kailes Biller Stubbeman Family Foundation Mr. Paul E. Vernon Mr. Willard G. Wood, Jr. Ellen O. Blackstone Karen Hae-Kyung Sung and Jeff Robert Carl Jean Baur Viereck Woodward Canyon Winery Sandra A. Boeskov Kyle and Emi Suzuki Mr. Robert A. Virkelyst Conrad Wouters and Glenna Olson Barbara A. Bonamy Michael Swafford George and Laura Jane Viverette Craig and Joan Wrench Christine Borgen Gerald and Elizabeth Swan Mr. David Vos Virginia Wright Robert and Sheila Bosanko Brandon and Sami Sweeney Mr. Christopher D. Votta Scott and Jennifer Wroblewski Arthur R. Bowers Symetra Gives Brian and Susan Vowinkel Brian and Amy Wulfestieg Kim Carita Brandt Dr. Daniel Syrdal Mr. and Mrs. J. H. Waechter Doris A. Wunsch Sandra Brentlinger Sysco Central Pennsylvania, LLC Estelle C. Wagner Estate Ann P. Wyckoff Carol Hilborn Bridges Monte and Nan Szendre Melissa and Michael Wagner Mrs. Jean T. Wyckoff Christine L. and Michael L. Brinton Tacoma Rainiers Wagstaff, Inc. Yakima Valley Old Peoples’ Riding Club Mary and Geary Britton-Simmons Mr. Michael J. Tangen Gary and Sally Walcott The Yao Yuan Sze Foundation Elmore G. and Dorcas Brolin Don and Sharon Tapley Wallenpaupack OFPX, LLC Chris Yarrow Steve and Gayle Burditt Don and Betsy Tarbell Janis M. Walsh Mr. and Mrs. Lincoln E. Young Mrs. Jennie K. Burwell Jack Tawney and Megan Wood Sheri L. Ward Dr. Peter Zabback and Mr. and Mrs. Jack and Patty Bush Dr. Massih T. Tayebi Andrew and Emily Warden Mr. and Mrs. Lawrence E. Taylor Therese L. Wareham Mr. Richard S. Zahniser Phillip and Violette Carlson Tempus Cellars Joan K. Warmington Mr. Jack Zduriencik Eleanor E. and Ellen C. Carnwath Mr. and Mrs. John Tenneson Mr. Richard L. Warner Zenergy Health Club and Spa Douglas A. Case Ms. Eva Terry Drs. Edus and Linda Warren Dr. Stephen P. Zieniewicz and Hazel E. Case Ellen Kay Thomas Washington State Service - Beta Sigma Phi Jim and Paula Thomas Washington State University Athletics Ms. M. Jane Thomas Amy Watkins and Michael Reese In FY13, giving to Fred Hutch included Mylo and Marion Charlston Mr. Teddy R. Thomas Doug Watkins 29 anonymous benefactors. Ms. Barbara Chester Dick and Ruth Thomassen Mr. and Mrs. Larry M. Watkins Beti Thompson Shane Watkins and Alex Deesing Mrs. Barbara H. Thomson Jim and Diane Watson Legacy Partners in Research Mr. Milton M. Cohen Thorsen French Advocacy, LLC Mr. Joel A. Watson Legacy Partners in Research are individuals Bob and Sylvia Cook Jerry and Kathy Thramer Darren and Leann Watts who support Fred Hutch through a bequest Norma M. Corbin Ms. Rashelle D. Tidwell Ted and Ann Watts in their will, life income gift, life insurance, Fred Corrado William and Margaret Tinsley Mr. and Mrs. David H. Webster retirement asset or other planned gifts. As Mr. Martin J. Costello Perry Tirschwell Eric and Catherine Wedge Legacy Partners, they create a legacy for Mary Pat Cotty Andrew and Shana Tischaefer Steven and Dana Weiner themselves and their families and play a Fred M. Cox The Titus Will Families Foundation H. Janet Weiss pivotal role in benefiting future generations. Mr. and Mrs. Fenwick J. Crane Tom Douglas Catering & Events Wells Fargo Community Support Campaign Andrea and John Towlerton Renee and Paul Wesberry Barbara Trask and Ger van den Engh Mr. and Mrs. Barlow M. Westcott II Caroline and Joshua Traube Western Blend, Inc. Mr. Donald D. Ackley Joan A. De Bruin Treasure Island Family Fun Run/Walk Westhill Inc. Ms. Nancy Agajeenian Laura and Jim DiLella TRUEbenefits The Westin Verasa Napa Jim S. and June M. Allen Leslie and Deborah Disch Ian and Leslie Tubbs Westland Distillery Ms. Chelea Alwine Chris and Viki Parrott Dragich Gary and Amanda Tucci Eric and Daria Whettam Jan A. Amen Wayne D. and Susan E. DuPont Jeanne Tweten and James Leslie Kate Whettam Alex and Helen Andersen Lois and Earl Dusenbery Jim and Pat Twisselman Whitcomb Insurance Agency Dorothy E. Anderson Peter S. and Sandra W. Dyer Tyco Matching Gifts Program Mr. and Mrs. Stuart White Stuart L. and Karen C. Anderson Mr. and Mrs. Robert L. Ecker Vivien Tye Dan and Amy Wick Bill and Ruth Anderson Demerise Eddy Mr. Allan S. Tyson Peter and Karen Wickstrand Ms. Victoria Andrews Jerry L. and A. Christine Edwards The U.S. Bank Private Client Reserve Robin Wilcox Ardean A. Anvik Alvin and Maija Eerkes 38 Dr. Kristi Schermerhorn Dr. Linda J. Hipps Ruth Cannon Mary E. Cederlund Cora Chads Susan L. Christiansen Emanuel and Susan Cohen Roger and Gloria Crouch Charles M. Ackerman and Barbara Clanton Ackerman F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Barb and Art Daniels Daryl Drew Charitable Foundation P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Mr. and Mrs. Jeffrey B. Ellman, Esq. Larry and Linda LaBolle Sherry Y. Rae William and Susanna Wiegant Cecil David Enman and Norma J. Enman Mr. William M. and Dr. Geraldine K. Landis Weldin and Jo Ann Read Christopher L. and Ruby D. Wilde Katherine S. Eshelman Al and Laura Laney Liane Redpath-Worlund Carl H. Wittenberg Thomas G. and Kay Nozaki Ewing Mr. and Mrs. Gus Lange Thomas L. Reid Ms. Dawn M. Wood Colin Faulkner Lolita M. Lanning Mrs. Sally Reiquam Lois M. Woodcock and Richard H. Woodcock Mr. Richard Faulstich E. Margaret Lawrence Bruce and Karen Richards Penny M. Woods Anton M. and Barbara C. Fleischman Sam and Betty LeBid Foundation Douglass and Lea Richter Sarah Woods Jane B. Folkrod Roy and Vel Leonard Mr. and Mrs. Joe A. Riedel, Jr. Joseph and Janet Zinn Bob and Lanie Franza Marjorie J. Levar William A. Ritter Richard and Linda Frasch Mr. and Mrs. Stephen H. Lindquist William A. (Bill) Roberge Legacy Partners in Research members Bill and Deryn Fulton Ralph and Lynda Lipe Claudia Rollins include 190 anonymous benefactors. Larry Gahlhoff Lynn Lippert and Sal Jepson Mr. and Mrs. Thomas E. Roth Ross M. Galvin, M.D. and Patricia G. Galvin June B. and Johnnie I. Louderback Milton and Ruth Rubin Jane Gerhardt Phyllis J. Mandel Mr. Robert H. Rutledge Inner Circle Roman J. Gerstner and Evelyn R. Gerstner Stephanie D. Mapelli Cynthia and Gerry Salkowski The Inner Circle of the Legacy Partners in James D. and Paula J. Gillmore Inge Marcus Mary L. Sanderson-Schinman Research is comprised of current and former Mr. and Mrs. Wayne C. Gott Mr. and Mrs. Robert J. Margulis Colleen Swift Schafer Fred Hutch faculty, staff and their spouses; Ron and Cathy Grant Dr. and Mrs. Herbert A. Marra Patricia L. Schaumberg past and present members of the Board John and Ann Guerin Hank, Fuchsia and Marcia Martin Brent and Susan Schlosstein of Trustees, Board of Ambassadors and Jack and Dorothy Guinn Joan A. Martin Rosalyn H. Schuknecht Senior Council and their spouses; as well Martha W. Hanscom Mrs. Alma L. McDonald Robert E. Schultz as past members of the former Foundation JoAnne Hansen Marcia McGreevey-Lewis and Janet Sears Board of Directors and their spouses. It Dorothy L. Shattuck recognizes those who support Fred Hutch Mary Alberta Hargrove Robert D. Lewis, M.D. Andy and Carol Harris Douglas G. and Ruth J. McKnight Kenneth and Linda Shefveland through a bequest in their will, life income Mr. and Mrs. Robert Harrower, Jr. Elinor K. Menter Pam and Geoff Sheridan gift, life insurance, retirement asset or other Mrs. Mary E. Harvill Pipena Klieros Mercouriadis Jean Simmons planned gifts. John and Roberta Hayes June E. Miller Ms. Annette Siversen Hal and Jerry Haynes Robert Miller and Marlys Owen-Jones Mr. Eugene G. Sivertson Steven J. and Lisa M. Anderson Dr. Frederick and Margaret Hazeltine Verna L. Miller Mrs. Phyllis H. Smith Rich and Leslie Begert Patricia and Robert D. Heffernan, Jr. Mrs. Anne A. Moldrem Samuel E. and J. Michelle Smith Carl and Renee Behnke Mr. and Mrs. Severt S. Hegland, Jr. Mr. and Mrs. James A. Morrison Joseph T. Smudin Sally Skinner Behnke Ms. Jean S. Heidt Joan and Michael Morse Gregory P. Sokolowski Brian R. and Shelley J. Buck Andrea Helman and Samuel Helman Judy Mukai Herba Irene Solstad William W. and Kathy Lynn Christoffersen Mr. and Mrs. David C. Henderson David and Pam Mushen Mary Solum Mr. and Mrs. John D. Eastham Ralph and Gail Hendrickson Mr. and Mrs. Al Neelley Sara Somers Karl and Carol Ege Gregory and Anne-Marie Henry Ken and Julie O’Brien Mrs. Kathleen P. Spading Robert N. and Ingrid Lahti Eisenman Conrad W. Hewitt Mr. and Mrs. Homer Olsen Josephine and Stephen Spear Barbara Feasey and Bill Bryant Michael and Rosemarie Hitt Milton O. and Carole A. Olson James Speckbrock Ms. Linda L. Gainer Charlene P. Holt, MD Miss Elvi M. Olsson Jenny Rebecca St. Martin Kenneth and Beryl Goodchild Vivian and Les Houle Sheila and Mel O’Neal Mrs. Caren A. Staley Sheri Ray Greaves Mr. and Mrs. James W. Howard Everett and Dorothy O’Neill Mr. and Mrs. Clyde R. Strauss Marcia and Glenn Harrington Barbara Howell Mrs. Jean B. O’Neill Janet Swanson Debra and Chuck Holland Mr. and Mrs. George C. Hudspeth Stanford E. Opdyke Connie Taylor Shelley Kuni Hovind Mr. and Mrs. Paul S. Hunter Arthur and Viola Oquist Ken and Judy Thomas Deborah E. Kirsner Mr. and Mrs. James G. Hutton Robert B. Overhus Dick and Ruth Thomassen Lynette A. Klein Dr. and Mrs. Gordon L. Imlay Clyde W. Owen Marjorie J. Thorne Reginald S. Koehler III David and Gigi Jack Stanley Ozbolt Olive Tice Judy Kornell Douglas L. Jacobs Mr. James D. Paddleford and Mr. and Mrs. Michael J. Toennessen Rose Kowalski Dorothy Doyle Johnson Mr. Dent W. Davidson Frances Welguisz Tomasko Jerrold D. Liebermann and Linda J. Harris Mr. Douglas B. Johnson Mr. and Mrs. Jack G. Parks Mr. and Mrs. David T. Troxel David A. Little and Michelle A. Gray James A. and Holly F. Johnson T. Keith and Janet Patrick Karl R. and Marcile H. Turner Jeffrey and Ethel Maxwell Robert P. Johnston Grafton Pauls and LaVonne Pauls Mr. and Mrs. Robert E. Vallat Patricia McCowan Thomas M. Jones and Judith A. Edwards Harry and Katherine Pearce Jean Baur Viereck Robert D. and Patricia A. McDonald Elaine N. Kaald Kristian Pearson Joan L. Walston Neil and Nancy McReynolds Ellen Kam Frederick and Elizabeth Pedersen Jim and Diane Watson Karen and Jamie Moyer Mal and June Karfstedt Mary R. Pelan Steve and Dana Weiner Shan and Lee Mullin Ms. Heidi Kass Daniel J. Peters Sandra E. Weiss Han and Shawn Nachtrieb Ms. Deborah Kaufman George and Cynthia Pierce James P. Welch Paul and Carol Neiman Brant A. Keeney Julia B. Poduch Nick and Carol Westlund - Martin and Vicki Nelson Frederick and Julianne Klippert Mr. Ross Purintun Nora Korg Mr. and Mrs. Robert and Teresa Quigley Richard and Annette Whitaker Guy and Arlene Ott Mr. and Mrs. David Kremers Gus Raaum Marie Legaz Whitley and Michael Whitley John and Jean Rolfe 39 Supporting Organization F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Dr. Gilbert S. Omenn and Martha A. Darling P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Michael B. Rubin Lois and Earl Dusenbery Mrs. Frederick Kullman Nancy and Michael Ryan J. Orin and Charlene Edson Sandra L. La Haye* Skip and Marilla Satterwhite Karl and Carol Ege* Laura A. Landro and Richard E. Salomon John C. Scibek John and Christine Enslein Rae and Mark Lembersky* Gregory and Charlene Steinhauer President’s Circle The Eucalyptus Foundation Jim and Maureen Lico Dr. and Mrs. E. Donnall Thomas The President’s Circle is a distinguished Chris and Jenny Falk Lily Pointe Family Foundation Mrs. Barbara Thrasher group of individuals and corporate members Fortune Family Foundation* Lynn Lippert and Sal Jepson Bonnie and Jim Towne who share Fred Hutchinson Cancer The Foster Foundation Listwin Family Foundation Nancy Greenwood Vehrs and Jeff Vehrs Research Center’s vision for eliminating Mr. Robert Frey Benito and Carmen Lopez* James and Roberta Weymouth cancer and related diseases. President’s Edward and Karen Fritzky Family* Mark and Nikki Mahan* Circle members make annual gifts of Mrs. E. Peter Garrett Randy and Retta Main Inner Circle members include $10,000 or more, sustaining vital programs Michael and Lynn Garvey* James and Sheila Mallahan 11 anonymous benefactors. and funding innovative ideas as they The Geiger Family Foundation* David and Nathan Mandelbaum Family* emerge. Reflecting gifts received George and Margaret McLane Foundation David Mann and Ann Thomson Mann* January 1 - December 31, 2012. Mr. and Mrs. Robert L. Gerth* The Marco J. Heidner Foundation Dr. and Mrs. Kenneth Gitlin Trish and Peter May Committees, Councils and Guilds Fred Hutchinson Cancer Research Center’s The Anderson Foundation* D. Wayne and Anne E. Gittinger John and Liz McAdam* committees, councils, and guilds are Mrs. Dorothy E. Anderson David and Patricia Giuliani* Mr. Tim R. McCulloch comprised of volunteers throughout the Ric and Kaylene Anderson* Kari Glover and Thad Alston Richard and Kathryn Miyauchi Puget Sound area who come together to Mr. and Mrs. Eric J. Andrews Val and Ivene Goemaere* Mo-dazz for the Arts raise awareness for Fred Hutch’s mission. Anduin Foundation Charles Goggio, Jr. Mr. Dinarte Morais Through various activities and events, these Dr. Frederick and Dita Appelbaum* Dr. and Mrs. Mitchell H. Gold Joan Morse and Dean Hachamovitch* committed volunteers raise critical funds for Athena Partners Foundation Cameron and Elizabeth Green Shan and Lee Mullin* research and provide services for patients The Aven Foundation Rochelle Greenberg Multiple Myeloma Opportunities for and their family members. Bill and Pam Ayer Mark Groudine and Cynthia Putnam Joe and Karyn Barer Nancy Gudmundson Han and Shawn Nachtrieb Brosio Hamasaki Stein Guild Bayley Family Foundation* Donald Guthrie and Candace Tkachuck* National Breast Cancer Foundation, Inc. Climb to Fight Breast Cancer Committee Helene Behar Erik and Susan Hansen* Robert Nelsen and Ellyn Hennecke* Friends of the Hutch Carl and Renée Behnke* John and Suzanne Hansen Patti and Gene Neuberger Grace Heffernan Arnold Guild Sally Skinner Behnke* Deborah and Eric Haug Peter and Sheryl Neupert Hutch Award Luncheon Planning Committee David and Joanna Beitel* Mike and Judi Hickey* Charles and Eleanor Nolan IN for the Hutch Committee Yvonne M. Betson Trust – Mrs. Kamla R. Hingorani Norman Archibald Charitable Foundation Innovators Network Council Jeff and Ethel Maxwell* Seema Hingorani Carol-Ann O’Mack and John Deininger* Bezos family Peter and Peggy Horvitz* John and Billie O’Mack Jeff and MacKenzie Bezos The Horwitz Family Memorial Foundation Sujal and Meera Patel Jacob Green Charity Golf Classic Committee Cathy Boshaw and Doug Edlund* David and Shelley Hovind The Paul M. Anderson Foundation Live Auction Advisory Board Phillip and Karla Boshaw Mr. Norman E. Hubbard Harry Jonathan Pearce* Magnolia Guild Elisabeth Bottler* The Hutchinson Family* Mark and Nancy Pellegrino* Margaret E. Martindale Guild Mr. and Mrs. Erik P. Breivik* Hyundai Hope on Wheels Wayne and Christine Perry Olympia Guild Shari and Frederick Burns* The Ildhuso Family* Dean and Josephine Petterson Partners for Survivorship Council Gary and Catherine Bylund* Nea Lynn Ireland Pete and Wilma Olsen Foundation* Premier Chefs Dinner Advisory Board Carl & Norma Alt Foundation Anne Irwin John B. Piacentini Family* President’s Circle Council Carlson Family Foundation* J. Orin Edson Foundation Paul and Beth Picardo* Charles B. See Foundation* Mr. Michael H.N. Jacejko Dean and Gwenn Polik and Valerie Polack* Brad and Judy Chase* Henry and Mary Ann James* Quest for Truth Foundation Dr. Joseph B. Chastain The Jean E. Thomson Foundation* RACE Charities Foundation Drs. Steven and Kathy Collins Mike and Diane Johansson* R.B. and Ruth H. Dunn Charitable Foundation Jordan and Katie Corey The John C. and Karyl Kay Hughes Foundation* Andre and Lisa Radandt Larry and Amy Corey Lisa Johnson of Johnson James and Sherry Raisbeck Institute for Prostate Cancer Research Community Leaders Council Barbara Cosgrove and Frank Yandrasits 40 International Industries Research & Education James V. Ramsdell, Jr. Tim Cosgrove* Mr. and Mrs. J. Michael Johnston* Andrew and Christine Reinland Virginia Cosgrove David Jones and Maryanne Tagney-Jones* Paula and Stephen Reynolds Roger and Gloria Crouch* Mr. and Mrs. Tim C. Jones Richard C. Goldstein Private Foundation Kurt and Leslie Dammeier Rich and Karmann Kaplan Jim Roberts and Pam Becker* Judy Dart Keith & Mary Kay McCaw Family Foundation Ron and Katie Robertson Mark Davis Keyes Foundation* Robinett Family Steve Davis and Bob Evans Roger and Lee Kintzel Elizabeth W. Robinson and Angeline M. Dick* Craig and Danna Kinzer Holly and Eric Dillon* The Klingman Open Mr. Tom Robinson and Ms. Carla Murray Susan and Tom Dolbert Reg and Ann Koehler* The Rona Jaffe Foundation The Dr. Maxwell Hurston Family Foundation, Inc. Harry Korrell Milton and Ruth+ Rubin* Jan Dulet* Mike and Debbie Koss* Satya and Rao Remala Foundation* F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T John McVickar Robinson P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Jim and Bet Schuler* Drs. Daniel and Elizabeth Corey Tyler and Anna Jones Bill and Marlene Semple* Jordan and Katie Corey Brian and Christy Kadien Craig Shrontz and Lynn Ristig Stephanie J. Crabtree James and Angela Kahler Frank and Harriet+ Shrontz* Suzanne and Joseph DellOrfano Jonathan and Pamela Kil Philip and Snookey Simon Donor Advised Fund Innovators Network Members Curt and Anita Dieren & Sons Susan Kim Mark and Brenda Simons Innovators Network (IN) is the next Satnam Doad Denise R. Kindle Jim and Jan Sinegal* generation of community leaders who share Eric and Tracy Dobmeier Jeff and Michelle Knoll Doug and Marilyn Southern* a commitment to funding innovative, life- Justin Donoghue and Dora Rozis Harry Korrell Tom and Diane St. John* saving research at Fred Hutch. IN members Russell and Marion Dorer* Richard Kyle and Kara Matthew* Howard and Cynthia Steinberg are age 45 and under and make annual Charles Dorner Hannele Laine Charlene and Greg Steinhauer* contributions of $1,000 or more to support Traci L. Drake and Ann Torres Blake Lanz John and Sherry Stilin high priority projects that accelerate the RayAnn DuBose Amy and Aaron Lavin Dr. Rainer Storb and Dr. Beverly Torok-Storb pace of promising research. Reflecting gifts Collette L. Duck Daniel A. Lelewski Cynthia Stroum* received January 1 - December 31, 2012. Todd and Virginia Dutkin Clark and Lori Lindsay Jeffrey and Karen Edwards Matt and Elisha Logue* Suskin Foundation The Swanson Family Garrett and Tina Abel Tracey and Mike Elfstrom Christi Ball Loso* Mr. and Mrs. Stephen G. Tandy Aisha Ahmad Al Khinji Lawrence and Brittni Estrada Jeffrey and Jennifer Lounsberry Thomas C. Wright Foundation Stephanie Alexander and Michael Wilson Jennifer Evans and Darin Kudrna* Sandra Low and Christopher Flynn* Mikal and Lynn Thomsen* Curt and Ashley Anderson Brett J. Ferullo Elizabeth and Brian Lund* Barbara Thrasher and Rick Koffey Lisa Anderson Scott and Amy Finholm* Diana Lynn Bradley and Danielle Tilden Tyler R. Andrews Mark and Jayme Freeborn Dennis and Vannessa Ma Bonnie and Jim Towne* Jill Argo Lisa Fritzky Brian M. Maloney UMC Charitable Foundation Geoff and Catherine Austin Ryan L. Fritzky and Susie M. Fritzky Jason J. Maloney Tom and Margo Van Halm* Sarah C. Avery Phil and Lisa Gafken Ryan and Sara Maxwell* Van Sloun Foundation* Dylan and Kalimar Avila-Petitt Michelle Geiger and Jon Ashley* Peter J. May Vijay and Sita Vashee Eric Bahna The Geiger Family Foundation Tod and Christa McBryan* Lawrence Votta Thomas Baksay Shelley and Lee Gill Michael D. McCann Doug and Maggie Walker* Chris and Keri Balmer* Harold and Kim Ginsburg Michelle McCormick Tom and Jeanne Walker Richard and Joanne Barber Kelley Goldmanis Nancy McLaren Mr. Joseph N. Walter and Ms. Kathy L. Mares Gena Barker* Douglas Gordon Dmitriy Meyerzon Bruce and Peggy Wanta Matthew and Kerstin Bates Roger and Jennifer Grambihler* Michael and Lisa Miller Elizabeth Wayner Stephanie Beck Matt Gregg Richard B. Miller II Bryan and Pamela Weeks Doug Bennyhoff, Jr. and Sarah L. Bennyhoff Susanne and Scott Guthrie* Nikki and Chris Milonas Nancy Weintraub Yahn Bernier and Beth McCaw* Jessica Michel Hagan and Curtis Hagan Jonathan Morrison and Lucy Davies* Mr. and Mrs. James L. Wellinghoff Ken and Shiori Betzler Steve and Karen Hall Marianne G. Mowat James and Roberta Weymouth* Sue Biggins Casey Hamilton Ulrich Mueller and Diana Ensenat* Mr. and Mrs. John Whetzell Corrina Black Ryan and Eileen Harasimowicz* Trevor and Marci Nolan Woldenberg Foundation Joseph Blake Jeff Hardie and Laurie Saito* Jesse and Samantha Noonan The Yeck Family Joel M. Blatt John W. Harnish Fred Northup, Jr. and Ashley Northup Melinda Yount Joey and Jennifer Borrelli Kevin and Bobbi Harrison David Notario and Latife Lacin Richard and Janet Yulman Chris and John Brandenfels Scott and Rachel Harter Heather Nunn John and Nancy Zevenbergen Aaron Bregel* Adam Hartzell Roger F. Nyhus Joseph and Janet Zinn* Randall R. Broad John N. Healy Donald and Kristi Oates Daniel Bronson Jeffrey and Shelly Heier* Christian and Kristin O’Meara President’s Circle members include Michele Brooks Todd and Stephanie Henderson* Jesse Ottele eight anonymous benefactors. Stephen and Jennifer Brooks* Justin and Catherine Hendrickson Mark and Jennifer Pawlosky* Bradley and Amy Brotherton Mr. and Mrs. Troy Hickey* Kemp C. Peterson Corporate Members of the Bryan and Joy Brown Brent and Dulcy Hixson Paul M. Peterson President’s Circle Troy and Kristin Buckley* Brandon Hoff Michael and Heidi Plaster* Aequitas Capital Management Ishmael Burns Dayton D. Hoffman Darin Postma Amgen Carl and Angela Bush Tobias M. Hohl Caleb and Ann Powell Costco Wholesale Billy and Katie Butler Todd and Kate Holmes Nicole and Michael Pratapas Michael’s Toyota of Bellevue Erica and Jose Campos Trevor and Donabelle Huffmaster Elizabeth Prescott and Daniel Stetson* Perkins Coie LLP Mark and Lisa Caputo* Olivier and Catherine Humbert* Chris and Elissa Puckett Platt Family* Charlotte Cashill Kyle Hutchins Robert and Victoria Quiles* Safeway Inc. Gwen E. Ceccanti Scott and Amy Hutchinson* Andre and Lisa Radandt Seventh Avenue Associates LP Steven and Michelle Chattin Kurt and Clair Jensen Suri and Mala Raman Turner Construction* Lisa Chiang* Allen and Carleigh Johnson* James Ramsey ZGF Architects LLP* Charlie Chung* Brent and Catherine Johnson* Nicky and Jeff Razwick Simon Clarke and Alice Burden David and Christy Johnson Allison Reed Dr. Shannon Corbin and Andrea Jones* Andrew and Christine Reinland Dean and Stacy Jones Srilakshmi Remala Kamdar and Viren Kamdar* *charter members +deceased members 41 Mr. Jonathan M. Tingstad F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T P RIVAT E C O N T R I BUTOR S F I SCA L Y E AR 201 3 Srilata D. Remala Seattle Cancer Care Alliance Alderbrook Ladies Golf Club Maurice Rice The Seattle Cancer Care Alliance (SCCA) Alderwood Middle School Family & Students Terry and Ben Richardson unites the world-class treatment and Mrs. Tamara Anderson Kitsap Destruction Derby Association Amy Ring research activities of Fred Hutchinson Dr. Frederick and Dita Appelbaum Mr. and Mrs. Jamie R. Korte David W. Robinett Cancer Research Center, UW Medicine and Mr. Robb Bakemeier and Mr. and Mrs. Michael W. Landry Jason and Carol Rockhill Seattle Children’s. In fiscal year 2013, over Scot F. Rogers 2,100 donors contributed more than $2.3 Bank of America Mr. and Mrs. Kenneth D. Lawson James Rose million to the SCCA to support efforts to Bauer Moynihan & Johnson LLP Tom and Janet Leeds Calvin and Lauren Rowland provide premier, patient-focused care and Beats for Boobs, Seattle LeRoss Family Foundation Andrew Ryder access to groundbreaking clinical research Ms. Patricia Berg Mr. Lester M. LeRoss Justine and Rob Sands to patients from around the world. Chris and Valerie Berglund Mr. Harry A. Linker Mr. and Mrs. Steve W. Berman Ms. Kristine A. Logan David and Lisa Schilling Mrs. Karen Rosengren JP Morgan Chase Foundation Matching Gift & Volunteer Program Brian and Diane Langstraat Alexander B. Schirer $250,000 - $499,999 Ms. Nancy Blaisdell The Lookout Foundation, Inc. Chris Schlecht* The Safeway Foundation Elisabeth Bottler Low Pressure Promotions, LLC Bill and Toni Boyd Scott F. Lundberg Walter and Michelle Schmetzer Daniel R. Schroeder $100,000 - $249,999 Mr. Keith Boyer Mr. Murdock D. MacPherson, Jr. Casey and Allison Schuchart AEG Live Debbie Brandjord Ms. Lisa M. Magnusson Mark Schuster Mr. and Mrs. William D. Boden Madeline Buelt & Dan Craig Kimberly McNally and Mark Sollek, MD Janice and Mike Selman The Madhouse Project Dr. David R. Byrd Meridian Valley Country Club Ladies Division Matt and Kathy Sentena Swim Across America Mr. and Mrs. Ross N. Case Anya R. Miller Kabir and Noreen Shahani $50,000 - $99,999 Dr. and Mrs. Mike Casey, M.D. Mr. and Mrs. John H. Mills Mark and Susan Shapiro* Delta Dental Washington Dental Service Manisha and Devindra Chainani Mr. and Mrs. Scott L. Morris Teung Shen and Johannes Thijssen Muckelshoot Indian Tribe Dr. and Mrs. Martin A. ‘Mac’ Cheever Shan and Lee Mullin Jennifer J. Slifka June B. Wright Estate Mr. John P. Chilcote Mr. and Mrs. Wilbur Mundy City Of Ephrata NW Spokes 4 Hope Kelly E. Smith Joseph and Jennifer Sprague $25,000 - $49,999 Bret J. Clark Thomas W. and Margaret E. Olsson George Stathakopoulos and Nicole Miller Microsoft Corporation The Columbia Foundation Mr. Eric Parker John and Patricia Stockamp* Sterling Realty Organization Dr. and Mrs. Steven Connelly Lynn C. Patten Stephen and Sheila Styrchak Wings of Karen Dr. Shannon Corbin and Nat and Poo Penrose Karen Sung and Jeff Carl Mr. Jonathan M. Tingstad Erik Peterson Kyle and Emi Suzuki $10,000 - $24,999 Coughlin Porter Lundeen Mr. R. Stewart Phelps Michael Swafford* Broadway Across America Ms. Marcia E. Danne Mrs. Roberta W. Piercy Sherri Swingle Johnson and Matt Johnson* Jane and David Cottrell Ms. Daphne Dejanikus Jay and Julia Portnoy Andrew and Shana Tischaefer Jacobs Johnson Foundation Mr. Domenick Dellino Mr. Kartik Raghavan Andrea Towlerton Kidder Matthews Delman Family Trust Mr. and Mrs. Robert Richardson Luis and Colette Ulloa* Perkins Coie LLP The Dittrich Family Dr. Sharon Romm Dr. Anthony Van Ho Seattle Aquarium Eastside Catholic School Jon and Judy Runstad Danielle VanNoy Seattle Symphony Expedia Inc Sal’s Babershop Mr. and Mrs. Robert C. and Mr. and Mrs. Scott and Kelly Saunders James and Kallie Veeneman Brian and Susan Vowinkel $5,000 - $9,999 Susanne Wagner-Fischer Bob Miller Foundation Janice L. Ferguson Mr. and Mrs. Eugene Skiffington Andrew and Emily Warden* Maria Burke Mr. and Mrs. Roy T. Ferguson Karen Marcotte Solimano and Cherie R. Warren Mr. and Mrs. Steven D. Cedergreen Fight for Life Amy Watkins and Michael Reese Charter Construction Foster Pepper, PLLC Mr. and Mrs. Jim K. Specht Shane Watkins and Alex Deesing Dr. Joy B. Chastain and Dr. John R. Simpson Ms. Michelle Fusman Mr. John C. Sroufe Yonnie Watkins East Bay Community Foundation J. James and Margel S. Gallagher The Staves Family Eric and Catherine Wedge Employees Community Fund of Mark and Deborah Gentzen Mr. Forrest M. Stewart Mr. and Mrs. Ralph and Bea Gilfilen Gary J. Strauss glassybaby Mrs. Nancy Glickman Timothy C. Sullivan Paul Lauzier Charitable Trust Mr. and Mrs. Robert Gordon Mr. David W. Todd Eric and Daria Whettam Performance Wheel Mark Groudine and Cynthia Putnam Dr. Joseph Traube and Dr. Christine White Kate Whettam The Schwartz Center for Mr. Ramiro J. Gutierrez Ms. Mary Triska and Ms. Mary Ledbury Harold M. Harlan Frank and Betty Vandermeer Renee and Paul Wesberry* Kristen Wellinghoff Wheeler and Christopher Wheeler Randall and Tonya Williams The Boeing Company Compassionate Care Vera Ellen Fahl Schneider Family Foundation James P. Solimano Maria and Jeff Wolcott Seattle Sounders FC Mr. and Mrs. Gordon L. Harman Keith A. Vormsberg Corinne Woodward Mr. David Singer Ms. Sylvia Hartman Mrs. Shirley A. Vormsberg Brian and Amy Wulfestieg Stairing is Caring Mr. and Ms. Brian Hartnett Washington State Employee Tangerine Travel Charity Foundation Iva and Lawrence Hirsch United Way of King County Mrs. Loretta A. Hogg Grace and Elliott Wilson Giving to Innovators Network includes two anonymous benefactors. *charter members 42 Combined Fund Drive Mr. Robert Hoppa and Ms. Sandy Shaw Dr. Ronald K. Winkle $1,000 - $4,999 Mr. Norman E. Hubbard Woodland Park Zoo Society Mr. and Mrs. David P. Ackerson Ms. Jonelle M.C. Johnson WSECU Aerojet Rich and Aimee Jones Mrs. Glen B. Youell F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T F I N A NCI AL S UM M A RY FRED HUTCHINSON CANCER RESEARCH CENTER FISCAL YEAR 2013 (IN THOUSANDS OF DOLLARS) OPERATING REVENUES FISCAL YEAR 2013 n Research Grants and Contracts $329,211 (80%) n Other Income 50,204 (12%) n Net Contributions 19,182 (5%) n Investment Income 12,261 (3%) $331,834 (78%) 87,049 (20%) OPERATING EXPENSES FISCAL YEAR 2013 n Program Services – Research n Facilities and Administration n Fundraising 9,256 SOURCES OF CONTRIBUTIONS FISCAL YEAR 2013 n Major Gifts 25% n Corporate and Foundation Relations 22% n Annual Giving 18% n Gifts of $10K - $49K 13% n Planned Giving 13% nEvents Fiscal year 2013 numbers are unaudited 43 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T 9% (2%) FRED HUTCHINSON CANCER RESEARCH CENTER BOA R D S J U LY 2 0 1 2 – J U N E 2 0 1 3 B OA R D O F T R U ST E E S B OA R D O F A M B AS SA D O R S Doug Walker, Chair Paula Reynolds, Vice Chair Steve Davis, Immediate Past Chair Karl Ege, Treasurer Ric Anderson, Secretary Holly Dillon Stephen Graham Ron Howell Henry James Rick Koffey Richard B. McCune Robert Nelsen Peter Neupert Charles Nolan, M.D. Jim Sinegal Vijay Vashee Carl Behnke, Co-Chair Patricia McDonald, Co-Chair Connie Anderson Robert M. Arnold + Ron Bayley Sally Skinner Behnke Ronald Berenson, M.D. Debbie Bevier Eric Bremner John Enslein Phelps Fisher Cathryn Fortune Edward Fritzky Kathryn Harris Deborah Haug Peter Horvitz John Hutchinson Stuart R. Hutchinson, M.D. Karmann Kaplan Rich Kaplan Reg Koehler Yvonne Lamey Jeff Maxwell Neil McReynolds Joan Morse Karen Moyer Shan Mullin Martin Nelson Gilbert Stanley Omenn, M.D., Ph.D. Nancy Pellegrino Charlotte Reed Rao Remala Satya Remala Jean Rolfe Keith Schorsch Harriet Shrontz + Alee Spencer Charlene Steinhauer Gerald R. Swanson Barbara Thrasher Bonnie Towne James Weymouth Roberta Weymouth Mary H. Wiese Scott Wilson +deceased LEAD E R SH I P Larry Corey, M.D. President and Director Frederick Appelbaum, M.D. Executive Vice President and Deputy Director Mark Groudine, M.D., Ph.D. Executive Vice President and Deputy Director Myra Tanita Executive Vice President and Chief Operating Officer Garnet Anderson, Ph.D. Senior Vice President Director, Public Health Sciences Division Jonathan Cooper, Ph.D. Senior Vice President Director, Basic Sciences Division Tony Bozzuti Vice President and Chief Information Officer Scott Rusch Vice President Facilities and Operations ANNUAL REPORT Susan Dolbert, Ph.D. Vice President Development Doug Shaeffer Vice President General Counsel Randy Main Vice President and Chief Financial Officer Jennifer Sizemore Vice President Communications and Marketing Fred Hutchinson Cancer Research Center Mail Stop J5-200 PO Box 19024 Seattle, WA 98109-1024 206.667.4399 www.fredhutch.org/annualreport Ulrich Mueller, Ph.D. Vice President Industry Relations and Clinical Research Support Paul Woloshin, Ph.D. Vice President Shared Resources Han Nachtrieb Vice President Human Resources Eric Holland, M.D., Ph.D. Senior Vice President Director, Human Biology Division Julie McElrath, M.D., Ph.D. Senior Vice President Director, Vaccine and Infectious Disease Division 44 F R E D H U TC H I N S O N C A N C E R R E S E A R C H C E N T E R | 2 0 1 3 A N N UA L R E P O R T Published by the Communications and Marketing Department © 2013 Fred Hutchinson Cancer Research Center Editor Clay Holtzman Project Manager Carla Blakeman Designer Kim Westphal Writers Andrea Detter Clay Holtzman Andy Koopmans Justin Matlick Rachel Tompa Benjamin Williams Developers/Multimedia Andrew Bacon Sean Downing Bo Jungmayer Heather Marsh Ian Schempp Photographers Stephanie Felix Suzie Fitzhugh Dean Forbes Matt Hagen Jim Linna Leah Nash Pete Pin Colin Stapp Shane Young Mail Stop J5-200, PO Box 19024, Seattle, WA 98109-1024 206.667.4399 1.800.279.1618 www.fredhutch.org